CN102988195A - Liposome anti-hair loss preparation - Google Patents
Liposome anti-hair loss preparation Download PDFInfo
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- CN102988195A CN102988195A CN2012105242366A CN201210524236A CN102988195A CN 102988195 A CN102988195 A CN 102988195A CN 2012105242366 A CN2012105242366 A CN 2012105242366A CN 201210524236 A CN201210524236 A CN 201210524236A CN 102988195 A CN102988195 A CN 102988195A
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Abstract
The invention relates to a liposome anti-hair loss cream, belonging to the technical field of cosmetics. The liposome anti-hair loss cream comprises the following components in parts by weight: 0.5-8.0 parts of epidermal growth factor (EGF), 0.01-0.1 part of human stem cell growth factor (SCGF), 0.003-3000.0 parts of phospholipid, 0.001-100.0 parts of vitamin H, 0.001-100.0 parts of ginkgetin, 0.001-10.0 parts of fibroin, 0.01-100.0 parts of collagen, 0.01-100.0 parts of histidine, and 0.001-200.0 parts of cholesterol. The liposome anti-hair loss cream provided by the invention has the beneficial effects that the liposome is composed of phospholipid bilayers and contains pure water micro vesicles, and the vesicles can enclose a certain amount of nutrients and essences, are 100 nanometers in mean diameter which is 1/200-1/300 of the human cell diameter, can easily penetrate through the surface layer of human skin and can be fused with cells, thus exerting efficacy. The liposome anti-hair loss cream can deeply humidify horny cells and enhance hydration to improve the skin softness, and can provide sufficient nutrients to ensure hair health and increase the flexibility and elasticity.
Description
Technical field
The present invention relates to a kind of liposome anticreep hair cream, relating in particular to a kind ofly can increase hair elasticity, pliability, and can make the liposome anticreep hair cream of anti-alopecia, belongs to the cosmetic product technical field.
Background technology
Skin is comprised of epidermis, corium, subcutaneous fat and appendages.Epidermal area is outermost one deck of skin, is divided into from inside to outside: basal cell layer, prickle cell layer, granular cell layer, clear cell layer and horn cell layer.Skin appendages comprises hair, hair follicle, sebaceous gland and sweat gland.Skin mainly absorbs external substance, i.e. horny layer, pilosebaceous unit and the antiperspirant mouth of pipe by three approach.Its mesocuticle is the most important approach that skin absorbs, skin can only absorb some electrolyte under normal circumstances, small-molecule substance and liposoluble substance, can not directly absorb for some macro-molecular proteins, in the daily life, most anticreep hair cream are aqueous solutions, and epidermal growth factor, collagen protein, ginkgetin, the important life active compound such as histidine all is water miscible, and the exogenous lipid of horny layer secretion and the endogenous lipid of sebaceous gland Lipid Secretion are oily matter, and water soluble nutrients chance oiliness lipid is insoluble, as shown in Figure 1, therefore cause conventional water solublity anticreep hair cream utilization rate very little.
Summary of the invention
For overcoming the existing shortcoming of prior art, goal of the invention of the present invention provides a kind of liposome anticreep hair cream, and it is carried to deep skin take liposome as carrying China with various nutritional labelings, fully absorbed by human body, increase hair elasticity, pliability, also can make anti-alopecia.
For realizing described goal of the invention, a kind of liposome anticreep hair cream, it comprises the composition of following ratio of weight and number:
Preferably, the composition that also comprises following ratio of weight and number:
Compared with prior art, liposome anticreep hair cream provided by the invention, it is carried to deep skin take liposome as carrying China with various nutritional labelings, can increase hair elasticity, pliability, also can make anti-alopecia.
Description of drawings
Fig. 1 is the sketch map of the skin absorption process of the skin care item that provide in the prior art;
Fig. 2 is the sketch map of the skin absorption process of liposome anticreep hair cream provided by the invention.
The specific embodiment
The present invention is further illustrated below in conjunction with specific embodiment.
Embodiment 1
This embodiment provides a kind of increases hair elasticity, pliability, and can prevent the liposome anticreep hair cream of alopecia.Described liposome anticreep hair cream comprises the composition of the weight part ratio described in the following table:
| Composition | Concrete content mg |
| Epithelical cell growth factor (EGF) | 0.5-8.0 |
| Human stem cell growth (SCGF) | 0.01-0.1 |
| Phospholipid | 0.003-3000.0 |
| Biotin | 0.001-100.0 |
| Ginkgetin | 0.001-100.0 |
| Fibroin | 0.001-10.0 |
| Collagen protein | 0.01-100.0 |
| Histidine | 0.01-100.0 |
| Cholesterol | 0.001-200.0 |
The preparation method of the liposome anticreep hair cream that this embodiment provides is: 100mg phospholipid and 25mg cholesterol are dissolved in the 30ml ethanol (perhaps chloroform, methanol or dichloromethane etc.), even the solution I of vibrating, then put into eggplant-shape bottle, constantly rotating under the jolting on the water-bath Rotary Evaporators, reduction vaporization desolventizes (35 ℃ ± 1 ℃ of bath temperature) to remove, and pass into every now and then nitrogen, until fully volatilization, then at room temperature dry 24 hours; Take by weighing that 3.0mg epidermal growth factor, 0.05mgSCGF (available from Peprotech company), 5mg fibroin, 5mg collagen protein, 20mg histidine, 25mg biotin and 25mg ginkgetin are dissolved in the 40ml deionized water (perhaps aqueous phosphatic PH=6.8) and constantly shaking up to get aqueous solution II under the rotation jolting on the water-bath Rotary Evaporators; Then above-mentioned aqueous solution II is added in the above-mentioned eggplant-shape bottle, constantly obtaining the liposome emulsion under the rotation jolting on the water-bath Rotary Evaporators, spy formula Ultrasound Instrument makes the abundant aquation 20-120 of lipid membrane minute under the ice-water bath condition, until become transparently to emulsion, obtain carrying the liposome anticreep hair cream of an epidermal growth factor, human stem cell growth, fibroin, collagen protein, biotin and ginkgetin.
Fig. 2 is the sketch map of the skin absorption process of liposome anticreep hair cream provided by the invention.As shown in Figure 2, because it is similar to human body cell outer membrane structure and composition to seal the liposome adventitia of nutritional labeling, so gap and the direct transdermal of skin subsidiary pipeline opening that complete liposome can pass between horn cell, the horn cell enter site of action.Liposome provides exogenous bilayer lipid membrane, make structural change between horn cell, hydrophobicity afterbody arrangement disorder in the double-layer of lipoid, fat-soluble medicine can enter intercellular substance by diffusion and capillarity, horny layer humidifying and hydration are strengthened, thereby can be penetrated easily the horny layer of epidermis and arrive each position of skin.Liposome phospholipid and Stratum corneum lipids merge changes the horny layer the Nomenclature Composition and Structure of Complexes, form a kind of flat grain structure, by the lipid granule gap, liposomal encapsulated medicine or nutritional labeling are convenient to enter skin, via lipid exchange, fusion, safeguard the physiological function of skin, therefore the liposome of sealing nutritional labeling or medicine has the biomembranous characteristic of human body cell and function, affect the activity of cell, to participate in the human body metabolism, keep one of necessary basic substance of human normal physiological function, have targeting as pharmaceutical carrier, long-lasting, pardon, lipotropy and hydrophilic.Because liposome has avirulence and immunogenicity, be applicable to biological vivo degradation, can protect the entrapped superficial growth factor and metallothionein, and can carry the nutritional labelings such as the superficial growth factor and fibroin and pass horny layer and enter corium and subcutaneous tissue.The nutritional labelings such as alleviation, the controlled release superficial growth factor in corium and subcutaneous tissue.Because liposome has targeting, can improve the superficial growth factor etc. in the bioavailability of skin.
The liposome anticreep hair cream that present embodiment provides is on probation through 100 Mies of 30 years old to 45 years old, and after 20 days, 90% people's hair elasticity strengthens, pliability is good, and obviously no longer alopecia.
Embodiment 2
This embodiment provides a kind of increases hair elasticity, pliability, and can make the liposome anticreep hair cream of hair restoration.Described liposome anticreep hair cream comprises the composition of the weight part ratio described in the following table:
| Composition | Concrete content mg/L |
| Epithelical cell growth factor (EGF) | 0.5-8.0 |
| Human stem cell growth | 0.01-0.1 |
| Lipoid | 0.001-1000.0 |
| Phospholipid | 0.003-3000.0 |
| Fatty acid | 0.001-1000.0 |
| Biotin | 0.001-100.0 |
| Ginkgetin | 0.001-100.0 |
| Fibroin | 0.001-10.0 |
| Collagen protein | 0.01-100.0 |
| Histidine | 0.01-100.0 |
| Vitamin E | 0.001-200.0 |
| Vitamin C | 0.001-200.0 |
| Vitamin K | 0.001-200.0 |
| Cholesterol | 0.001-200.0 |
The preparation method of the liposome anticreep hair cream that this embodiment provides is: with phosphatidase 11 00mg, lipoid 100mg, fatty acid 100mg, 25mg vitamin E, 25mg vitamin K and cholesterol 25mg, be dissolved in the 40ml ethanol (perhaps chloroform, methanol or dichloromethane etc.), even the solution I of vibrating, then put into eggplant-shape bottle, constantly rotating under the jolting on the water-bath Rotary Evaporators, reduction vaporization desolventizes (35 ℃ ± 1 ℃ of bath temperature) to remove, and pass into every now and then nitrogen, until fully volatilization, then at room temperature dry 24 hours; Take by weighing that 3.0mg epidermal growth factor, 0.05mgSCGF (available from Peprotech company), 5mg fibroin, 5mg collagen protein, 20mg biotin, 20mg ginkgetin, 20mg histidine and 25mg vitamin C are dissolved in the 50ml deionized water (perhaps aqueous phosphatic PH=6.8) and constantly shaking up to get aqueous solution II under the rotation jolting on the water-bath Rotary Evaporators; Then above-mentioned aqueous solution II is added in the above-mentioned eggplant-shape bottle, constantly obtaining the liposome emulsion under the rotation jolting on the water-bath Rotary Evaporators, spy formula Ultrasound Instrument makes the abundant aquation 20-120 of lipid membrane minute under the ice-water bath condition, until become transparently to emulsion, obtain carrying the liposome anticreep hair cream of the compositions such as an epidermal growth factor, human stem cell growth.Preferably, described phospholipid is lecithin.
The liposome anticreep hair cream that present embodiment provides is on probation through 100 Mies of 30 years old to 45 years old, and after 10 days, 90% people's hair elasticity strengthens, pliability is good, and obviously no longer alopecia.
In addition, can liposome and solution separating be opened with the SephadexG50 chromatographic column if need.
Liposome anticreep hair cream provided by the invention is the high-tech carrier for active principle in a kind of tip, consisted of by the phospholipid bimolecular, include the miniature vesicle of water purification, the nutritional labelings such as the quantitative epidermal growth factor of the internal energy encapsulation of vesicle, human stem cell, its average diameter is 100 nanometers, is 1/200～1/300 of human body cell diameter, can penetrate easily the human body skin top layer, with cell fusion, the performance effect.Therefore, liposome anticreep hair cream provided by the invention is the natural nutriment of hair follicle development, both can be used for treating natural on-off cycles of hair growth and grown the alopecia person who hinders, also can be used as the hair healthy daily indispensable nursing product of being grown up, and be used for delaying cell aging, prevent the generation of excessive alopecia.
The using method of liposome anticreep hair cream provided by the invention:
1, after the hair washing this product evenly spread upon on scalp and the hair and stop after 5 minutes, clear water is cleaned and is got final product;
2 or temperature to bathe 10 minutes effects better; 3, consumption is too much unsuitable, smears all with skin and hair to be as the criterion.
The effect that below describes in conjunction with the embodiments component of the present invention, preparation method in detail and reach, but embodiment only is for the explanation the present invention of demonstration ground.Description only is for explaining claims.But protection scope of the present invention is not limited to description.Any those skilled in the art of being familiar with are in the technical scope that the present invention discloses, and the variation that can expect easily or replacement all should be encompassed within protection scope of the present invention.Therefore, protection scope of the present invention should be as the criterion with the protection domain of claims.
Claims (2)
1. liposome anticreep hair cream, it comprises the composition of following ratio of weight and number:
2. lipid anticreep hair cream according to claim 1, it also comprises the composition of following ratio of weight and number:
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210524236.6A CN102988195B (en) | 2012-12-10 | 2012-12-10 | Liposome anti-hair loss preparation |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210524236.6A CN102988195B (en) | 2012-12-10 | 2012-12-10 | Liposome anti-hair loss preparation |
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| CN102988195A true CN102988195A (en) | 2013-03-27 |
| CN102988195B CN102988195B (en) | 2014-12-10 |
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| CN201210524236.6A Expired - Fee Related CN102988195B (en) | 2012-12-10 | 2012-12-10 | Liposome anti-hair loss preparation |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105997735A (en) * | 2016-07-13 | 2016-10-12 | 周帅 | Natural hair washing and caring article and preparation method and application thereof |
| CN112826875A (en) * | 2021-03-15 | 2021-05-25 | 福建广生健康科技有限公司 | Traditional Chinese medicine hair growing cream for treating alopecia and preparation method thereof |
| US11617706B2 (en) | 2020-06-29 | 2023-04-04 | The Procter & Gamble Company | Hair conditioning composition free of fatty alcohol |
| US11969490B2 (en) | 2021-06-17 | 2024-04-30 | The Procter & Gamble Company | Hair conditioning composition with antimicrobial system |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1078138A (en) * | 1993-03-06 | 1993-11-10 | 青岛海洋大学 | Liquid for hair-growth |
| CN1310627A (en) * | 1998-07-28 | 2001-08-29 | 梅迪科股份有限公司 | Hair growth/maintenance compositions and methods involving the same |
| CN101054579A (en) * | 2007-03-29 | 2007-10-17 | 上海复旦新杨生物科技有限责任公司 | A siRNA capable of preventing and curing hair loss and accelerating hair growth, and preparation method and application thereof |
| CN101199837A (en) * | 2007-11-30 | 2008-06-18 | 何荫良 | Humanized cell factor hair agent and preparing method thereof |
-
2012
- 2012-12-10 CN CN201210524236.6A patent/CN102988195B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1078138A (en) * | 1993-03-06 | 1993-11-10 | 青岛海洋大学 | Liquid for hair-growth |
| CN1310627A (en) * | 1998-07-28 | 2001-08-29 | 梅迪科股份有限公司 | Hair growth/maintenance compositions and methods involving the same |
| CN101054579A (en) * | 2007-03-29 | 2007-10-17 | 上海复旦新杨生物科技有限责任公司 | A siRNA capable of preventing and curing hair loss and accelerating hair growth, and preparation method and application thereof |
| CN101199837A (en) * | 2007-11-30 | 2008-06-18 | 何荫良 | Humanized cell factor hair agent and preparing method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 裘炳毅: "《化妆品化学与工艺技术大全》", 30 June 1997 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105997735A (en) * | 2016-07-13 | 2016-10-12 | 周帅 | Natural hair washing and caring article and preparation method and application thereof |
| CN105997735B (en) * | 2016-07-13 | 2019-08-06 | 奥俐莱雅（广东）家化科技有限公司 | A kind of natural hair-washing hair-care articles and its preparation method and application |
| US11617706B2 (en) | 2020-06-29 | 2023-04-04 | The Procter & Gamble Company | Hair conditioning composition free of fatty alcohol |
| CN112826875A (en) * | 2021-03-15 | 2021-05-25 | 福建广生健康科技有限公司 | Traditional Chinese medicine hair growing cream for treating alopecia and preparation method thereof |
| US11969490B2 (en) | 2021-06-17 | 2024-04-30 | The Procter & Gamble Company | Hair conditioning composition with antimicrobial system |
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| CN102988195B (en) | 2014-12-10 |
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Granted publication date: 20141210 Termination date: 20181210 |