CN105796460A - Seabuckthorn oil body lotion containing hydrolyzed pearl powder flexible nano liposome - Google Patents
Seabuckthorn oil body lotion containing hydrolyzed pearl powder flexible nano liposome Download PDFInfo
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- CN105796460A CN105796460A CN201610162446.3A CN201610162446A CN105796460A CN 105796460 A CN105796460 A CN 105796460A CN 201610162446 A CN201610162446 A CN 201610162446A CN 105796460 A CN105796460 A CN 105796460A
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- skin
- pearl powder
- flexible nano
- hydrolyzed pearl
- liposomes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
Abstract
The invention provides seabuckthorn oil body lotion containing hydrolyzed pearl powder flexible nano liposome. The seabuckthorn oil body lotion is prepared by conducting emulsification and homogenizing on the hydrolyzed pearl powder flexible nano liposome, seabuckthorn oil, emulgator, a moisturizing agent, stablizer and deionized water. Multiple nutrition substances including amino acid, microelements, polypeptide and the like contained in the hydrolyzed pearl powder are utilized, and metabolism of skin epithelial cells and dermal fibroblasts is effectively enhanced; the flexible nano liposome can penetrate through the skin surface of the human body easily to combine with cells, so that pearl powder plays a better functions, in cooperation with seabuckthorn oil which deeply moistens skin cutin to form cells and enhance the hydration of the dermal skin, the flexible nano liposome and the seabuckthorn oil jointly act, regeneration of a skin barrier and dermal collagen can be better promoted, skin texture is improved, health of the skin can be guaranteed, and skin resistance is enhanced. The seabuckthorn oil body lotion is natural, mild, nearly free of stimulation and capable of being used for moistening skin and preserving moisture for a long time, has good water supplementation and moisture preservation effects on dry skin, sensitive skin and the like and effectively whitens the skin.
Description
Technical field
The invention belongs to cosmetic product technical field, relate to a kind of milky lotion, particularly relate to a kind of Oleum Hippophae skin care item containing hydrolyzed pearl powder flexible nano-liposomes, be a kind of can solve the problem that skin is intensely dark, flexibility decrease, dry aging problem, the liposome skin care item that moisturizing repairing effect is good.
Background technology
Skin is made up of epidermis, corium, subcutaneous fat and appendages.Epidermal area is the outermost one layer of skin, is divided into from inside to outside: basal cell layer, prickle cell layer, granular cell layer, clear cell layer and keratinocyte layer.Skin appendages includes hair, hair follicle, sebaceous gland and sweat gland.Skin absorbs external substance mainly through three approach, i.e. horny layer, pilosebaceous unit and sweat duct mouth.Its mesocuticle is the most important approach of skin absorption, skin can only absorb some electrolyte under normal circumstances, small-molecule substance and liposoluble substance, can not directly absorb for some macro-molecular proteins, in daily life, most skin care milks are aqueous solutions, Margarita powder isoreactivity material is all water miscible, and the endogenous lipid of the exogenous lipid of horny layer secretion and sebaceous gland lipid secretion is oily matter, and water soluble nutrients chance oiliness lipid is insoluble, the water-soluble skin care product utilization rate thus resulting in routine is only small, use water-soluble skin care product for a long time, easily cause nutritional labeling waste and also easily block pore.
Pharmaceutical carrier lipid physical ability wetting surface skin, makes horny layer imbibition；Have an effect with keratodermatitis, change its ordered arrangement, make skin surface form reversible little space, medicine or drug-loaded liposome in moment and enter into deep skin (skin corium) by these spaces, thus being absorbed by organisms；With the sebaceous gland of skin surface, hair follicle, sweat gland mouth effect, make medicine or drug-loaded liposome arrive deep skin by these ducts, skin permeation of drugs had obvious facilitation.Flexible nano-liposomes particle diameter is little, height self-deformation, efficiently through the skin duct of several times less of himself, some macromolecular substances being difficult to transdermal can be made to be successfully entered skin, circulate even into body, the Cutaneous permeation of medicine is had significant facilitation.Flexible nano-liposomes can change the physicochemical property of proto-drug simultaneously, strengthens pharmacological action and the curative effect of medicine, improves bioavailability, be a kind of novel carrier for transdermal delivery.
Margarita is acknowledged as cosmetic good merchantable brand always, and its beauty treatment mechanism is to contain aminoacid and the trace element of various needed by human body in Margarita, and needed for the nutritional labeling contained in Margarita and mankind's skin, nutrient is close, is easy to be absorbed by the body, has the effect of whitening, speckle dispelling.The active component utilizing Margarita in current cosmetics mainly carries out with the form of hydrolyzed pearl powder, owing to Margarita containing various trace elements, electrical conductivity is higher, such as direct interpolation, it is easy to destroy the system of cosmetics, and be directly appended in cosmetics by Margarita hydrolyzed solution its active component and be easy to by other component breakage in cosmetics so that it is lose activity and be difficult to be absorbed by the body.Hydrolyzed pearl powder is prepared into flexible nano-liposomes; the destruction to cosmetics series can be reduced; and can effectively protect the active component of Margarita not destroyed by other components in cosmetics; and the active substance of Margarita can be carried to the deep skin of human body by this hydrolyzed pearl powder flexible nano-liposomes; improve bioavailability, reach better aesthetic health care effect.
Oleum Hippophae is the complex of multivitamin and bioactive substance.Its VC content occupy one cut fruit, first of vegetable, it is described as " king of VC ", VC is kind of a natural internal whitening agent, can effectively suppress the deposition of abnormal pigment on skin and the activity of tryrosinase, and help the reduction of dopachrome (tyrosine transforms into melanic intermediate), formed thus reducing melanin, effectively clean white muscle skin, and collagenation in epithelial tissue can be promoted, increase the immunologic function of skin；Contained VE can eliminate free radical and resist Oxidation, keeps the unsaturated fatty acid in cell not oxidized when light, heat radiation；Contained carotene can be converted into VA, and then eliminates epithelial tissue keratinization or abnormal rough.Its multivitamin contained and multiple unsaturated fatty acid synergism, re-epithelilization can be promoted, it is obviously improved skin epidermal cells circulatory function, repairs skin and promote the microcirculation of capillary of skin, it is suppressed that the carrying out of lipid peroxidation, improve metabolism, delay skin aging process, can keep the sour environment of skin, has the effect of antiallergic, bactericidal antiphlogistic, and there is stronger saturating property, it is a kind of desirably natural skin care product raw material.
Summary of the invention
For overcoming the shortcoming existing for prior art, it is an object of the invention to provide a kind of Oleum Hippophae milky lotion containing hydrolyzed pearl powder flexible nano-liposomes, it is with liposome for carrier, nutritional labeling is carried to deep skin, utilization is fully absorbed by human body, these skin care item can solve the problem that skin is intensely dark, flexibility decrease, dry aging problem, and moisturizing repairing effect is good.
For realizing described goal of the invention, the Oleum Hippophae milky lotion containing hydrolyzed pearl powder flexible nano-liposomes of the present invention is made up of by weight percentage following component: hydrolyzed pearl powder flexible nano-liposomes 2-15%, Oleum Hippophae 5-15%, emulsifying agent 5-20%, wetting agent 10-20%, stabilizer 1-20%, surplus is deionized water, and the percentage composition sum of each component is 100%.
Hydrolyzed pearl powder flexible nano-liposomes in said components, is mainly made up of soybean lecithin, sodium cholate, hydrolyzed pearl powder, and particle diameter is at 10nm-100nm.
One or more in PEG40 stearate, PEG60 castor oil hydrogenated, Tween 80, Polyethylene Glycol (300) monoleate, Macrogol 4000, branched fatty acid ester and Fatty acid macrogolglycerides of emulsifying agent described in said components.
Wetting agent described in said components is one or more in vaseline or lanoline.
Stabilizer described in said components is one or more in glycerol, spermol (cetyl alcohol), propylene glycol or butanediol.
The preparation method that it is a further object to provide described hydrolyzed pearl powder flexible nano-liposomes, is realized by following steps:
(1) quantitatively weigh fabaceous lecithin, sodium cholate, hydrolyzed pearl powder are dissolved in chloroform；
(2) water-bath 37.5 DEG C, chloroform removed under pressure；
(3) evacuation preserves 5h；
(4) add isotonic phosphate buffer liquid (pH7.4), Rotary Evaporators rotates after hydration 1h again and removes organic solvent, form flexible lipidosome suspension；
(5) liposome turbid liquor is placed in ice-water bath and is interrupted after ultrasonic 30min through probe-type, after filtering with 0.2 μm of filter, obtain flexible nano-liposomes.
The preparation method that it is also another object of the present invention to provide described Oleum Hippophae milky lotion, is realized by following steps:
(1) weighing Oleum Hippophae and the oil phase dispensing such as emulsifying agent, wetting agent of formula ratio, stirring mixes, and heating obtains homogeneous oil phase compound to 75 DEG C；
(2) oil phase compound is added in whipping process stabilizer and deionized water, mix homogeneously, emulsifying it, after being cooled to 50 DEG C, add hydrolyzed pearl powder flexible nano-liposomes, homogeneous, be cooled to 35 DEG C, discharging obtains finished product.
The present invention utilizes the several amino acids contained in hydrolyzed pearl powder and the nutrient substance such as trace element, polypeptide, effectively strengthens the metabolic function of skin epidermal cells and corium fabric blast cell.Flexible nano-liposomes average diameter is 100 nanometers, is the 1/200～1/300 of human body cell diameter, can penetrate human body skin top layer easily, and Cell binding, makes Margarita powder better play effect.It is aided with Oleum Hippophae go deep into humidifying skin keratin formation cell and strengthen the hydration of dermis of skin.Both can better promote skin barrier and dermal collagen new life at combined effect.Improve skin texture.To ensure the health of skin, strengthen skin resistance.Product of the present invention is natural, gentle, almost without stimulation, it is possible to do skin moistening moisturizing for a long time, and dry skin quality, sensitive skin quality etc. have good replenishing water and preserving moisture effect, and can effectively clean white muscle skin.
Detailed description of the invention
Below in conjunction with detailed description of the invention, principles of the invention and feature being described, example is served only for explaining the present invention, is not intended to limit the scope of the present invention.
Embodiment 1:
Hydrolyzed pearl powder flexible nano-liposomes:
Soybean lecithin 5.5wt%
Sodium cholate 1.5wt%
Hydrolyzed pearl powder 1.5wt%
The preparation of hydrolyzed pearl powder flexible nano-liposomes:
(1) quantitatively weigh fabaceous lecithin, sodium cholate, hydrolyzed pearl powder are dissolved in chloroform；
(2) water-bath 37.5 DEG C, chloroform removed under pressure；
(3) evacuation preserves 5h；
(4) add isotonic phosphate buffer liquid (pH7.4), Rotary Evaporators rotates after hydration 1h again and removes organic solvent, form flexible lipidosome suspension；
(5) liposome turbid liquor is placed in ice-water bath and is interrupted after ultrasonic 30min through probe-type, after filtering with 0.2 μm of filter, obtain flexible nano-liposomes.
The embodiment 2 one kinds Oleum Hippophae milky lotion containing hydrolyzed pearl powder flexible nano-liposomes
Oil phase composition:
Said components (oil phase dispensing) stirring being mixed, heating obtains homogeneous oil phase compound to 75 DEG C；In whipping process, add the deionized water of 60wt%75 DEG C, mix homogeneously, emulsifying it, after being cooled to 50 DEG C, add 4wt% hydrolyzed pearl powder flexible nano-liposomes (embodiment 1), homogeneous, be cooled to 35 DEG C, finished product is packed to obtain in discharging.
Embodiment 3: a kind of Oleum Hippophae milky lotion containing hydrolyzed pearl powder flexible nano-liposomes
Oil phase composition:
Oleum Hippophae 15wt%
Tween 80 10wt%
Vaseline 10wt%
The stirring of above-mentioned oil phase dispensing being mixed, heating obtains homogeneous oil phase compound to 75 DEG C；In whipping process, add the deionized water of 10wt% glycerol and 42wt%75 DEG C, mix homogeneously, emulsifying it, after being cooled to 50 DEG C, add 13wt% hydrolyzed pearl powder flexible nano-liposomes (embodiment 1), homogeneous, be cooled to 35 DEG C, finished product is packed to obtain in discharging.
Describe the component of the present invention, preparation method and the effect reached above in association with embodiment in detail, but embodiment illustrates the present invention with being only for demonstration.Description is only for explaining claims.But protection scope of the present invention is not limited to description.Any those familiar with the art in the technical scope of present disclosure, the change that can readily occur in or replacement, all should be encompassed within protection scope of the present invention.
Embodiment 4 compliance test result
Being participated in using milky lotion of the present invention from the women of the various skin types of 20 to 60 years old by 80 ages, every women is previously every average daily uses that there is prestige or at least one natural or organic skin care products of medicine cosmetic board.Wherein 50 participants are sensitive skin, are defined as presently, there are such as flushing heating, tight sense, desquamation or acneform lesion.Participant's morning and evening every day face after the cleaning uses the present composition, substitutes conventional skin-protection product.After using surrounding, participant completes questionnaire.Result of study alkali table 1.
Table 1
Participant all admits this product to no skin irritation, substantially feels skin comfort, softness after using, and without greasy feeling, has obvious sun-proof whitening effect, and sunburn is had good reparation effect, reduces the skin lesion cicatrix of acne.
Claims (7)
1. the Oleum Hippophae milky lotion containing hydrolyzed pearl powder flexible nano-liposomes, it is characterized in that, it is made up of by weight percentage following component: hydrolyzed pearl powder flexible nano-liposomes 2-15%, Oleum Hippophae 5-15%, emulsifying agent 5-20%, wetting agent 10-20%, stabilizer 1-20%, surplus is deionized water, and the percentage composition sum of each component is 100%.
2. a kind of Oleum Hippophae milky lotion containing hydrolyzed pearl powder flexible nano-liposomes according to claim 1, it is characterized in that, described hydrolyzed pearl powder flexible nano-liposomes, is made up of soybean lecithin, sodium cholate, hydrolyzed pearl powder, and particle diameter is at 10nm-100nm.
3. a kind of Oleum Hippophae milky lotion containing hydrolyzed pearl powder flexible nano-liposomes according to claim 1, it is characterized in that, one or more in PEG40 stearate, PEG60 castor oil hydrogenated, Tween 80, Polyethylene Glycol (300) monoleate, Macrogol 4000, branched fatty acid ester and Fatty acid macrogolglycerides of described emulsifying agent.
4. a kind of Oleum Hippophae milky lotion containing hydrolyzed pearl powder flexible nano-liposomes according to claim 1, it is characterised in that described wetting agent is the one in vaseline or lanoline or two kinds.
5. a kind of Oleum Hippophae milky lotion containing hydrolyzed pearl powder flexible nano-liposomes according to claim 1, it is characterised in that described stabilizer is one or more in glycerol, spermol, propylene glycol or butanediol.
6. a kind of Oleum Hippophae milky lotion containing hydrolyzed pearl powder flexible nano-liposomes according to claim 1 and 2, it is characterised in that described hydrolyzed pearl powder flexible nano-liposomes is prepared by following steps:
(1) weigh fabaceous lecithin, sodium cholate, hydrolyzed pearl powder are dissolved in chloroform；
(2) water-bath 37.5 DEG C, chloroform removed under pressure；
(3) evacuation preserves 5h；
(4) add the isotonic phosphate buffer liquid of pH7.4, Rotary Evaporators rotates after hydration 1h again and removes organic solvent, form flexible lipidosome suspension；
(5) flexible lipidosome suspension is placed in ice-water bath and is interrupted after ultrasonic 30min through probe-type, after filtering with 0.2 μm of filter, obtain flexible nano-liposomes.
7. the preparation method of a kind of Oleum Hippophae milky lotion containing hydrolyzed pearl powder flexible nano-liposomes described in claim 1, it is characterised in that realized by following steps:
(1) taking Oleum Hippophae and the oil phase dispensing such as emulsifying agent, wetting agent, stirring mixes, and heating obtains homogeneous oil phase compound to 75 DEG C；
(2) oil phase compound is added in whipping process stabilizer and deionized water, mix homogeneously, emulsifying it, after being cooled to 50 DEG C, add hydrolyzed pearl powder flexible nano-liposomes, homogeneous, be cooled to 35 DEG C, finished product is packed to obtain in discharging.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610162446.3A CN105796460A (en) | 2016-03-21 | 2016-03-21 | Seabuckthorn oil body lotion containing hydrolyzed pearl powder flexible nano liposome |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610162446.3A CN105796460A (en) | 2016-03-21 | 2016-03-21 | Seabuckthorn oil body lotion containing hydrolyzed pearl powder flexible nano liposome |
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| Publication Number | Publication Date |
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| CN105796460A true CN105796460A (en) | 2016-07-27 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610162446.3A Pending CN105796460A (en) | 2016-03-21 | 2016-03-21 | Seabuckthorn oil body lotion containing hydrolyzed pearl powder flexible nano liposome |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021251934A1 (en) * | 2020-06-08 | 2021-12-16 | Yeditepe Universitesi | Method of obtaining sea buckthorn (hippophae rhamnoides) extract encapsulated with liposomal technology for use in cosmetic formulas |
-
2016
- 2016-03-21 CN CN201610162446.3A patent/CN105796460A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021251934A1 (en) * | 2020-06-08 | 2021-12-16 | Yeditepe Universitesi | Method of obtaining sea buckthorn (hippophae rhamnoides) extract encapsulated with liposomal technology for use in cosmetic formulas |
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Application publication date: 20160727 |