CN112826837A

CN112826837A - Traditional Chinese medicine composition for treating hair/scalp diseases and application thereof

Info

Publication number: CN112826837A
Application number: CN202110276793.XA
Authority: CN
Inventors: 李振阳; 骆林敏; 刘美钦; 唐湘成
Original assignee: Fujian Guangsheng Health Technology Co ltd
Current assignee: Fujian Guangsheng Health Technology Co ltd
Priority date: 2021-03-15
Filing date: 2021-03-15
Publication date: 2021-05-25

Abstract

The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating hair/scalp diseases and application thereof, and the traditional Chinese medicine composition for treating the hair/scalp diseases comprises the following components in parts by weight: 1-20 parts of rhizoma drynariae, 1-20 parts of salt, 1-20 parts of divaricate saposhnikovia root, 1-10 parts of mulberry leaf, 1-20 parts of fructus viticis, 1-10 parts of pine needle and 1-10 parts of cimicifugae foetidae. The shampoo comprises a dispersion liquid and a main medicine containing the traditional Chinese medicine composition, wherein the dispersion liquid comprises a surfactant, alcohols and water. The main drug is a particle prepared by embedding the traditional Chinese medicine composition with gelatin. And uniformly stirring the particles and the dispersion liquid to obtain the traditional Chinese medicine shampoo. The traditional Chinese medicine hair mask comprises dispersion liquid and main medicine containing the traditional Chinese medicine composition. The traditional Chinese medicine shampoo and the traditional Chinese medicine hair mask have good curative effects on treating hair/scalp diseases.

Description

Traditional Chinese medicine composition for treating hair/scalp diseases and application thereof

Technical Field

The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating hair/scalp diseases and application thereof.

Background

The hair or scalp diseases include excessive dandruff, alopecia, acne, dry hair, and oil.

Alopecia is a very common phenomenon in people, and serious alopecia not only affects the appearance of appearance instruments, but also suggests some problems possibly occurring in organisms. In recent years, this phenomenon has been gradually advancing toward the younger. The factors of endocrine disturbance, excessive use of hairdressing products, excessive pressure, diet, diseases and the like are the first causes of alopecia. These factors are often manifold and often difficult to predict and control, and thus hair loss is a problem that many people are always troubling.

TCM holds that "when qi and blood are excessive, mustache will cause mustache and white blood will cause failure of qi and blood, which must be treated by the theory. The hair is the excess of blood and can be deficient or excessive. Deficiency syndrome is caused by deficiency of liver and kidney, failure of blood to nourish and pathogenic wind attacking the body due to deficiency; this is an excess syndrome due to stagnation of liver qi, resulting in qi stagnation, blood stasis and malnutrition. Therefore, the local environment of the scalp, qi stagnation and blood stasis are also one of the most important causes of hair and scalp problems such as alopecia and dandruff.

The prior patents relate to the following traditional Chinese medicine shampoo and shampoo paste for treating diseases of hair and scalp:

the invention patent with application number 201610276788.8, "a moringa shampoo and a production method", is filed for the day: 2016-04-29, which discloses a shampoo, the product is prepared from fresh leaves of moringa oleifera, fresh leaves of mint, mulberry leaves, hemp leaves, garlic, ginger, monkshood, angelica dahurica, radix sileris, polygonum multiflorum extract, ginseng extract, angelica sinensis extract, ganoderma lucidum extract, aloe extract, saffron extract, salt, essence, deionized water and the like according to a proportion, and the shampoo can effectively remove dandruff and prevent alopecia, can keep the hair moisture for a long time, and is black, beautiful and glossy, thereby achieving the effects of natural hair care and hair nourishing. However, some medicinal materials such as ginseng, ganoderma lucidum, saffron and the like in the formula are too expensive, ginseng is a wild medicinal material with secondary protection, and the medicinal materials are precious and fine medicinal materials with excellent oral administration effect and waste natural resources too much when being used in shampoo products. At the same time, the product lacks effective surfactants and does not have lathering and cleansing capabilities.

The invention patent with application number 201310664662.4, hair loss preventing and hair washing and conditioning agent, application date: 2013-12-11, which discloses a hair washing and conditioning agent, which is prepared from tea bran, mulberry leaf, fructus viticis, ginger, tuber fleeceflower stem, gecko, ligusticum chuanxiong hort and other traditional Chinese medicines in proportion, and mainly has the effects of promoting hair growth and preventing alopecia. However, geckos are secondary protection wild medicinal material species, and fructus viticis is tertiary protection wild medicinal material species, and the medicinal materials are better applied to oral administration rather than external application.

In the invention patent with patent publication number CN100368011C, a massage liquid for treating hyperosteogeny and lumbar intervertebral disc protrusion and a preparation method thereof are disclosed. However, the massage liquid is used for treating hyperosteogeny and lumbar intervertebral disc, and the effect of preventing alopecia is not mentioned.

At present, shampoo products are various in variety, functional products for blacking hair, preventing hair loss and the like are diversified, and products guided by the theory of traditional Chinese medicine are also few, wherein the overlord hair-loss-preventing shampoo is typical of traditional Chinese medicine hair-loss-preventing shampoo, but the effect is only bad.

In the invention patent of application No. 201510699882.X, "a hair growth membrane and a preparation method thereof", application date: 2015-10-26, a hair mask is disclosed, which is prepared from Usimma grass juice, aloe gel, polygonum multiflorum water extract, seaweed gel particles and the like according to a proportion. However, the hair mask may have problems in terms of use compliance such as pungent odor during use.

The invention patent with application number 201510085524.X discloses a non-steamed thermal nutrient hair film, which is applied for the day: 2015-02-17, discloses a hair mask, which is prepared from capsicum frutescens extract, water, glycerol, propylene glycol, behenyl trimethyl ammonium chloride, cetostearyl alcohol, polydimethylsiloxane, dimethiconol, trimethylsiloxyphenyl polydimethylsiloxane, dicocoyl ethyl hydroxyethyl methyl ammonium methyl sulfate, propylene glycol dicaprylate/dicaprate, PPG-1 trideceth-6, polyquaternium-37, acantha seed oil, ginseng root extract, panthenol, hydrolyzed yeast protein, aloe barbadensis leaf extract, hydrolyzed sericin, sodium hyaluronate, glutamic acid, lysine, capsicum frutescens extract, citric acid, hydroxyphenyl ethanol, essence and the like according to a proportion. The use of too much chemical agents may cause irritation to the scalp, eyes, mouth and nose, and the like.

At present, hair mask products are various in variety, functional products for blackening hair, preventing alopecia and the like are diversified, and products guided by the traditional Chinese medicine theory are not few, but the products are not strong in effect, and have side effects such as irritation and the like.

Disclosure of Invention

Technical problem to be solved

In order to solve the above problems of the prior art, the present invention provides a Chinese medicinal composition effective for treating hair/scalp diseases;

correspondingly, the invention provides the traditional Chinese medicine shampoo which is externally used and can effectively treat hair/scalp diseases and the preparation method thereof.

Correspondingly, the invention also provides a traditional Chinese medicine hair mask for external use, which can effectively treat hair/scalp diseases.

(II) technical scheme

In order to achieve the purpose, the invention adopts the main technical scheme that:

a traditional Chinese medicine composition for treating hair/scalp disorders, comprising the following components: rhizoma Drynariae and salt.

Rhizoma Drynariae is rhizome of Epilobium fern of Drynariae of Drynariaceae. Bitter taste and warm nature. Enter liver and kidney meridians. Regulating blood, dredging collaterals, nourishing liver and kidney, and replenishing essence and blood.

The salt is sea salt, mineral salt, lake salt, well salt, etc., and contains NaCl as main component and trace elements including Mg, Al, Si, K, Ca, Fe, S, etc. except NaCl, the functional groups are mainly in the form of sulfate radical, carbonate radical, silicate radical, hydroxyl radical in free and combined form, etc. Salty and cold. The traditional Chinese medicine holds that the salt has the effects of returning to the heart and kidney channels, cooling blood and improving eyesight.

The invention has the unexpected effect of combining the drynaria rhizome which is not considered to have the effect of treating the hair/scalp diseases such as the alopecia or the dandruff with the salt and has good effect of treating the hair/scalp diseases such as the alopecia and the dandruff.

In a preferable scheme of the traditional Chinese medicine shampoo, the traditional Chinese medicine composition further comprises one or a combination of more than two of the following components: radix Saposhnikoviae, folium Mori, fructus Vitics Simplicifoliae, folium Pini and cimicifugae rhizoma.

Ledebouriella root, a root of the plant Saposhnikovia divaricata (Turcz.) switzerland, of the family umbelliferae, scheschchk. Pungent and sweet with mild temperature. According to the traditional Chinese medicine, the divaricate saposhnikovia root enters bladder, liver and spleen channels. Dispel wind and relieve exterior syndrome, subdue dampness and alleviate pain, stop spasm.

Mulberry leaves, which are leaves of mulberry trees belonging to deciduous arbors of Moraceae, are bitter, sweet and cold in nature. It enters lung and liver meridians. Promote blood circulation to cool blood, dispel wind and clear heat.

Fructus Vitics Simplicifoliae is dried mature fruit of Vitex trifoliata Vitex trifolia L.var. Pungent, bitter and slightly cold. It enters bladder, liver and stomach meridians. Disperse wind-heat, clear head and eyes.

Pine leaves are needles of Pinus armandi Franch, Pinus taiwanensis Hayata, Pinus massoniana lamb, Pinus thunbergii Parl, Pinus tabulaeformis Carr, Pinus yunnanensis Franch, Pinus koraiensis Koraiensis Sieb et al. The traditional Chinese medicine considers that the pine leaves are bitter and warm. It enters heart and spleen meridians. Dispel wind and dry dampness, kill parasites and relieve itching, activate blood and tranquilize mind.

Cimicifuga foetida is dried rhizome of Cimicifuga trifoliata Cimicifuga herculeolia Kom., Cimicifuga dahurica (Turcz.) Maxim., Cimicifuga xing A Dahurica (Turcz.) or Cimicifuga foetida L. According to traditional Chinese medicine, the cimicifuga foetida is pungent, slightly sweet and slightly cold. It enters lung, spleen, stomach and large intestine meridians. Relieve exterior syndrome, promote eruption, clear heat and remove toxicity, and promote yang qi.

In the scheme, the radix sileris, the mulberry leaf, the fructus viticis, the pine needle or the rhizoma cimicifugae which do not have the effect of treating the hair/scalp diseases such as the alopecia and the dandruff are further combined with the rhizoma drynariae and the salt, so that the composition has stronger effect of treating the hair/scalp diseases such as the alopecia and the dandruff, and the effect is unexpected.

The traditional Chinese medicine composition comprises the following components in parts by weight: 1-20 parts of rhizoma drynariae, 1-20 parts of salt, 1-20 parts of fructus viticis, 1-10 parts of pine needles, 1-10 parts of cimicifugae foetidae, 1-20 parts of radix sileris and 1-10 parts of mulberry leaves.

The invention provides a traditional Chinese medicine shampoo for treating hair/scalp diseases, which comprises a dispersion liquid and a main medicine containing the traditional Chinese medicine composition of any scheme, wherein the dispersion liquid comprises a surfactant, alcohols and water.

The drynaria rhizome, the salt, the divaricate saposhnikovia root, the mulberry leaf, the fructus viticis, the pine needle and the cimicifuga foetida which do not have the effect of treating alopecia or dandruff and the like are combined, and are dispersed and dissolved in the shampoo formed by the dispersion liquid containing the surfactant and the alcohols, so that the shampoo has good effect of treating hair/scalp diseases, particularly alopecia and dandruff, and the effect is unexpected.

In the preferable scheme of the traditional Chinese medicine shampoo, the main medicine is particles prepared by embedding the traditional Chinese medicine composition with gelatin.

Gelatin (Gelatin) is a white or yellowish, semitransparent, slightly glossy sheet or powder which is partially degraded by collagen in connective tissues such as animal skin, bones, sarcolemma, fascial and the like; so it is also called animal gelatin and fat glue. The gelatin adopted by the invention is natural gelatin, can effectively embed the traditional Chinese medicine components in the invention, is used for improving the stability of the traditional Chinese medicine composition, prevents the active ingredients in the traditional Chinese medicine composition from losing in the storage process, and can effectively and slowly release in the use process.

In the preferable scheme of the traditional Chinese medicine shampoo, the main medicine is particles prepared by embedding the traditional Chinese medicine composition according to the following components in parts by weight, 1-10 parts of gelatin, 20-300 parts of water, 1-10 parts of emulsifier, 1-10 parts of coagulant and 1-10 parts of cross-linking agent.

Further, the coagulant is, but not limited to, sodium sulfate; the emulsifier is, but not limited to, tween-20; the cross-linking agent is, but not limited to, glutaraldehyde.

In a preferred embodiment of the Chinese medicinal shampoo, the surfactant comprises the following components: one or the combination of more than two of sodium laureth sulfate, cocamidopropyl betaine, cocamide DEA, polyquaternium-10 and sodium benzoate.

Further, the surfactant comprises the following components in parts by weight: 4-6 parts of sodium laureth sulfate, 1-3 parts of cocamidopropyl betaine, 0.2-1 part of cocamide DEA 1-3 parts and 0.2-1 part of polyquaternium-10.

In the technical scheme, sodium laureth sulfate, abbreviated as AES in English, is a white or light yellow gel paste or a colorless or light yellow liquid and is a main surfactant in shampoo. It is commonly used in daily chemical industries such as liquid washing, meal washing, shampoo and bath washing, and also used in industries such as textile, paper making, leather, machinery and oil exploitation. The cleaning agent has good cleaning and foaming performance, good water solubility, lower irritation than lauryl alcohol sulfate, and good compatibility with other surfactants and additives;

cocamidopropyl betaine, abbreviated as CAB in English, is a cosurfactant in shampoo and belongs to a zwitterionic surfactant. Has the functions of foam stabilization, foam enhancement, conditioning, washing aid and main surfactant irritation reduction;

the cocoanut oil amide DEA is totally called coconut oil diethanolamide, is 6501 for short, is one of cosurfactants, belongs to nonionic surfactants, and has the effects of stabilizing bubbles, increasing bubbles, thickening, increasing cleaning power and the like;

polyquaternium-10 is used as a conditioning agent and belongs to cationic polymers. Has effects of smoothing and softening hair, and facilitating combing.

In a preferred embodiment of the shampoo for washing the Chinese medicine, the alcohol comprises one or a combination of more than two of propylene glycol, ethanol, butylene glycol and glycerol. The alcohols comprise, by weight, 0.2-0.3 part of propylene glycol, 0.5-1 part of ethanol, 0.1-0.3 part of butanediol and 10-20 parts of glycerol.

Glycerin, also known as glycerol, is a colorless, odorless, sweet viscous liquid. Boiling point 290 deg.C, melting point 17.9 deg.C, relative density 1.2613. Can be infinitely miscible with water, has strong water absorption of anhydrous glycerin, and can be used as cosolvent in shampoo of the invention together with other alcohols.

In the preferable scheme of the traditional Chinese medicine hair washing water, the dispersion liquid further comprises camellia seed oil, horse fat, arginine and silk hydrolysate, and further comprises essence, EDTA tetrasodium, sodium chloride, horse fat, citric acid, arginine, camellia seed oil, sodium benzoate, silk hydrolysate and sodium hyaluronate.

Wherein the components are respectively as follows according to parts by weight: 0.01-0.05 part of essence, 0.05-0.2 part of EDTA tetrasodium, 1-2 parts of sodium chloride, 2-4 parts of horse fat, 0.05-0.1 part of citric acid, 1-2 parts of arginine, 0.5-1 part of camellia seed oil, 0.1-0.5 part of sodium benzoate, 1-2 parts of silk hydrolysate and 1-2 parts of sodium hyaluronate.

In the technical scheme, the EDTA tetrasodium salt, also called as ethylenediaminetetraacetic acid tetrasodium salt, is white powder, is easy to dissolve in water, is used as a chelating agent, and is used as an inorganic thickener to increase the viscosity so as to stabilize the solution.

Sodium Benzoate and Sodium Benzoate have antiseptic and bacteriostatic effects in shampoo, are broad-spectrum antimicrobial agents, and have good effects on yeast, mold and the like. The raw material is white particle or crystalline powder, is easily soluble in water and ethanol, and is slightly soluble in nonpolar solvents such as diethyl ether and acetone.

Sodium hyaluronate is an acidic mucopolysaccharide. Has special water retention function, and is the natural moisturizing factor with the best moisturizing effect in the natural world at present;

the camellia oil is natural oil extracted from camellia fruits, can promote hair growth, reduce phenomena of hair bifurcation, withered hair, scurf and the like, and simultaneously keep the hair black and bright;

the horse fat is fat extracted from horsehair parts on a horse body, contains rich nutrients and can make skin more tender;

the silk hydrolysate is hydrolysate of natural silk, is a composition containing abundant amino acids, peptides and proteins, and can promote skin improvement;

the essence mainly comprises various natural spices and essential oil, mainly comprises thymol and storax, and has various fragrance types, wherein the essence provided by the invention comprises all essences which can be used for the fragrance type in shampoo;

the citric acid is buffer in shampoo, and pure citric acid is colorless transparent crystal or white powder, has no odor and attractive sour taste, and can be used for regulating pH value of shampoo.

The preparation method of the traditional Chinese medicine shampoo in any scheme is prepared according to the following scheme but not limited to the following scheme.

The invention provides a preparation method of any one of the traditional Chinese medicine shampoos for treating hair/scalp diseases, which comprises the following steps:

s1: preparing a main drug, namely respectively carrying out superfine grinding on each component in the traditional Chinese medicine composition to prepare traditional Chinese medicine powder, mixing, and embedding the traditional Chinese medicine powder into particles through gelatin;

s2: preparing a dispersion liquid, namely dissolving all components prepared into the dispersion liquid in water, and homogenizing to obtain the dispersion liquid;

s3: and (4) uniformly stirring the particles and the dispersion liquid in the step (S1) to obtain the traditional Chinese medicine shampoo.

In a preferred technical scheme of the preparation method of the traditional Chinese medicine shampoo, in step S1, the method for embedding the microparticles comprises the following steps: dissolving 1-10 parts by weight of gelatin in 20-300 parts by weight of water, heating at 30-60 ℃, adding 10-150 parts by weight of traditional Chinese medicine powder, adding 1-10 parts by weight of emulsifier for emulsification for 10-50 min, adding 1-10 parts by weight of coagulant solution, stirring for 10-30 min, transferring to 0-4 ℃ water bath for stirring at 300-1500 rpm, adding 1-10 parts by weight of cross-linking agent for cross-linking and curing for 0.5-3 h, standing for 1-5 h, centrifuging at 500-2500 rpm, and taking precipitate to obtain particles; in step S3, the particles are mixed with the dispersion liquid and stirred at 10-100 rpm for 10-60 min.

The invention also provides a traditional Chinese medicine hair mask for treating alopecia or/and dandruff, which is characterized by comprising dispersion liquid and a main medicine containing the traditional Chinese medicine composition.

The traditional Chinese medicine composition comprises the following components: rhizoma Drynariae and Halitum.

The invention has the advantages that the drynaria rhizome which has no effect of treating hair/scalp diseases such as alopecia and dandruff is mixed with the salt, and the mixture is dispersed and dissolved in the dispersion liquid containing the surfactant to form a hair film, so that the effect of treating the hair/scalp diseases, particularly the alopecia and the dandruff is good, and the effect is unexpected.

Further, the traditional Chinese medicine composition also comprises one or the combination of more than two of the following components: radix Saposhnikoviae, folium Mori, fructus Vitics Simplicifoliae, folium Pini and cimicifugae rhizoma.

In the scheme, the radix sileris, the mulberry leaves, the fructus viticis, the pine needles or the rhizoma cimicifugae which have no effect of treating hair/scalp diseases such as alopecia, dandruff and the like are further combined with the rhizoma drynariae and the salt to prepare the hair mask for treating the hair/scalp diseases, particularly the hair mask for treating the alopecia and the dandruff has stronger effect compared with the hair mask prepared from the rhizoma drynariae and the salt, and the effect is unexpected.

In a preferable scheme of the traditional Chinese medicine film, the traditional Chinese medicine composition comprises the following components in parts by weight: 1-20 parts of rhizoma drynariae, 1-20 parts of salt, 1-20 parts of fructus viticis, 1-10 parts of pine needles, 1-10 parts of cimicifugae foetidae, 1-20 parts of radix sileris and 1-10 parts of mulberry leaves.

According to the scheme, the compatibility of the components in the traditional Chinese medicine composition is optimal through the proportion, and the finally prepared hair mask has a stronger effect of treating hair/scalp diseases such as alopecia and dandruff.

In the preferable scheme of the traditional Chinese medicine film, the main medicine is particles prepared by embedding the traditional Chinese medicine composition with glucomannan.

Glucomannan (Konjac Glucomannan, KGM) belongs to the superior product of soluble hemicellulose in the seventh human nutrient cellulose. Glucomannan has various unique physicochemical properties of water solubility, water retention and thickening, stability, suspension, gelation, bonding, film forming and the like. The traditional Chinese medicine composition is embedded in glucomannan to form particles, so that the stability of the traditional Chinese medicine composition is improved, the active ingredients in the traditional Chinese medicine composition are prevented from being lost in the storage process, and the active ingredients can be effectively and slowly released in the use process.

In the preferable scheme of the traditional Chinese medicine film, the main medicine is particles which are mainly formed by embedding the traditional Chinese medicine composition, and comprises 1-10 parts of glucomannan, 20-300 parts of water, 1-10 parts of emulsifier, 1-10 parts of coagulant and 1-10 parts of cross-linking agent.

Through the proportion in the scheme, the traditional Chinese medicine composition can be effectively embedded, and the effective slow release of active ingredients in the using process is ensured.

In a preferred scheme of the traditional Chinese medicine film forming, the dispersion liquid comprises a bacteriostatic agent, an acid-base regulator, a chelating agent, a nutrient additive, essence and water.

By the aid of the acid-base regulator, the chelating agent, the nutritional additives and the essence in the scheme, compatibility of the traditional Chinese medicine composition with scalp and hair after the traditional Chinese medicine composition is prepared into a hair film is improved, irritation is reduced, absorption rate of the hair and the scalp to active ingredients is improved, endocrine of the scalp and other unknown factors are regulated under the combined action of the nutritional additives, and hair/scalp diseases such as alopecia and dandruff are prevented.

In the preferred scheme of the traditional Chinese medicine film, the bacteriostatic agent comprises sodium benzoate, the pH regulator comprises citric acid, the chelating agent is tetrasodium EDTA, and the nutritional additives comprise glycerol, sodium hyaluronate, horse fat and silk hydrolysate. The essence can be one or more of concentrated apple essence, rose essence, etc.

In a preferable scheme of the traditional Chinese medicine film forming of the invention, the dispersion comprises the following components in parts by weight: 10-20 parts of sodium hyaluronate, 0.1-1 part of citric acid, 0.1-0.5 part of essence, 0.1-0.5 part of sodium benzoate, 0.5-2 parts of tetrasodium EDTA, 5-10 parts of camellia seed oil, 20-40 parts of horse fat, 10-20 parts of silk hydrolysate and 100-1000 parts of water.

Wherein, the Sodium Benzoate and Sodium Benzoate play the role of antisepsis and bacteriostasis, which is a broad-spectrum antimicrobial reagent and has good effect on saccharomycetes, mycete and the like. The raw material is white particle or crystalline powder, is easily soluble in water and ethanol, and is slightly soluble in nonpolar solvents such as diethyl ether and acetone.

The preparation method of the traditional Chinese medicine hair mask in any scheme is prepared according to the following scheme but not limited to the following scheme.

The invention provides a preparation method of a traditional Chinese medicine hair mask for treating hair/scalp diseases such as alopecia and dandruff, which comprises the following steps:

s1: preparing a main drug, namely respectively carrying out superfine grinding on each component in the traditional Chinese medicine composition to prepare traditional Chinese medicine powder, mixing, and embedding into particles;

s2: preparing a dispersion liquid, dissolving all components prepared into the dispersion liquid in water, and homogenizing;

s3: and (4) uniformly stirring the particles and the dispersion liquid in the step (S1) to obtain the traditional Chinese medicine hair mask.

In a preferred embodiment of the method for preparing a traditional Chinese medicine membrane of the present invention, in step S1, the method for embedding the microparticles comprises: dissolving 1-10 parts of glucomannan in water, heating at 30-60 ℃, adding 10-150 parts of traditional Chinese medicine powder, adding 1-10 parts of emulsifier for emulsification for 10-50 min, adding 1-10 parts of coagulant solution, stirring for 10-30 min, transferring to a water bath at 0-4 ℃, stirring at 300-1500 rpm, adding 1-10 parts of cross-linking agent for cross-linking and curing for 0.5-3 h, standing for 1-5 h, centrifuging at 500-2500 rpm, and taking precipitate to obtain particles; the fine particles obtained in step S3 are mixed with the dispersion liquid, and then stirred at 10-100 rpm for 10-60 min.

And further centrifuging at 500-2500 rpm to obtain precipitate, washing the precipitate with isopropanol for 1-6 times, filtering, and drying to obtain the fine particles.

In the preferable technical scheme of the preparation method of the traditional Chinese medicine membrane, the preparation method of the dispersion liquid comprises the following steps: dissolving each component for preparing the dispersion liquid into 100-1000 parts of deionized refined water, homogenizing for 30-120 s at 1000-3000 rpm of a homogenizer, and repeating for 1-5 times to obtain the dispersion liquid.

The traditional Chinese medicine hair mask dispersion liquid comprises the following components in parts by weight: 0.1-0.5 part of sodium benzoate, 0.5-2 parts of EDTA tetrasodium, 10-20 parts of glycerol, 10-20 parts of sodium hyaluronate, 5-10 parts of camellia seed oil, 20-40 parts of horse fat, 10-20 parts of silk hydrolysate, 0.1-0.5 part of essence and 0.1-1 part of citric acid.

The invention also provides a hair/scalp condition as described in any of the above embodiments for treatment, preferably but not limited to alopecia, dandruff.

(III) advantageous effects

The invention has the beneficial effects that:

the invention is formed by taking the theory of traditional Chinese medicine as guidance and carefully composing the prescription. The bone in the formula is broken and supplemented, the taste is bitter, the property is warm, and the formula can dredge the scalp, dispel the depression, promote the blood circulation and supply nutrition for the growth of hair follicles; fructus Viticis is pungent, bitter and cold in property, and can dispel wind and head heat, so it has the actions of clearing heat, dispelling wind and stopping oxygen. The two are monarch drugs, and can dispel head qi stagnation and blood stasis caused by various reasons regardless of cold and heat. The mulberry leaves are bitter and sweet in taste, cold in nature, bacteriostatic, anti-inflammatory and heat-clearing; the salt can soften hard mass and dissipate stagnation, and can diminish inflammation and clear heat; the pine needles are bitter, astringent and warm, have the functions of dispelling wind, activating blood circulation, detoxifying, killing parasites and relieving itching, and can promote blood circulation and improve the functions of capillary vessels. The three medicines are used as ministerial medicines, and the qi-tonifying and blood stasis-removing effects of the two monarch medicines are increased. The divaricate saposhnikovia root is pungent, sweet and slightly warm in property, and can expel wind, release exterior, dispel cold, relieve itching, remove dampness and relieve pain; the rhizoma cimicifugae is pungent, sweet and slightly cold in property, pungent can release exterior syndrome, slightly cold can clear heat and remove damp heat and greasiness on the surface of the scalp, further plays the roles of dispelling cold and diminishing inflammation, and promoting blood circulation and removing meridian obstruction in the whole formula, and is used as an adjuvant drug together. The traditional Chinese medicine composition has the effects of dispelling cold, clearing heat, dispelling wind, removing dampness, relieving itching and detoxifying, enables the scalp environment to achieve the healthy states of dispelling cold, removing heat, dispelling wind, removing dampness, and relieving itching, improves the living environment condition, and enables the hair in the scalp environment to naturally stop alopecia, grow more and grow healthily.

2. The preparation method combines the theory of traditional Chinese medicine, the prescription of traditional Chinese medicine and modern scientific and technical means, overcomes the defects of complicated process, low utilization rate, inconvenient use and the like of the traditional process, and replaces the advantages of high-efficiency preparation process, high-activity effective components, high-utilization-rate dosage form, application and the like, so that the product of the invention is more easily integrated into the life of people and can be used.

3. The traditional Chinese medicine composition of the invention is proved by experiments that: has obvious and definite curative effect on hair/scalp diseases, particularly alopecia and dandruff, and has the effective rate of more than 75 percent on alopecia. The recovery rate of the dandruff patients is more than 42.5 percent, the effective rate is 57.5 percent, and the ineffective rate is 0 percent.

Detailed Description

For a better understanding of the present invention, reference will now be made in detail to the present invention by way of specific embodiments thereof.

Specific examples of the Chinese medicinal composition

Example 1 a traditional Chinese medicine composition for treating hair/scalp disorders, comprising the following components in parts by weight: 1 part of rhizoma drynariae and 20 parts of green salt.

Example 2 a traditional Chinese medicine composition for treating hair/scalp disorders, which comprises the following components in parts by weight: 13 parts of rhizoma drynariae and 1 part of halite.

Example 3 a traditional Chinese medicine composition for treating hair/scalp diseases, which comprises the following components in parts by weight: 20 parts of rhizoma drynariae and 14 parts of salt.

Example 4: the traditional Chinese medicine composition for treating hair/scalp diseases comprises the following components in parts by weight: 16 parts of rhizoma drynariae, 20 parts of salt, 1 part of divaricate saposhnikovia root, 5 parts of mulberry leaf, 20 parts of fructus viticis, 1 part of pine needle and 5 parts of rhizoma cimicifugae.

Example 5: the traditional Chinese medicine composition for treating hair/scalp diseases comprises the following components in parts by weight: 1 part of rhizoma drynariae, 13 parts of green salt, 20 parts of divaricate saposhnikovia root, 1 part of mulberry leaf, 16 parts of fructus viticis, 10 parts of pine needle and 1 part of cimicifugae foetidae.

Example 6: the traditional Chinese medicine composition for treating hair/scalp diseases comprises the following components in parts by weight: 20 parts of rhizoma drynariae, 1 part of green salt, 12 parts of divaricate saposhnikovia root, 10 parts of mulberry leaf, 1 part of fructus viticis, 8 parts of pine needle and 10 parts of rhizoma cimicifugae.

Experiments prove that the traditional Chinese medicine composition prepared in the embodiments 1-6 of the invention: the treatment effect on hair/scalp diseases is obvious and definite, and the effective rate of treating alopecia patients is more than 70%; and single-factor experiments show that the use of the Qing salt is significantly more effective than other salts in treating patients with alopecia.

Example 7:

the traditional Chinese medicine shampoo for treating hair/scalp diseases comprises a dispersion liquid and a main medicine; the main medicine contains the traditional Chinese medicine composition in the embodiment 4. The dispersion comprises the following components in parts by weight: taking 40 parts of sodium laureth sulfate, 30 parts of cocamidopropyl betaine, 10 parts of cocamide DEA, 5 parts of polyquaternium-10, 0.5 part of sodium benzoate, 0.5 part of tetrasodium EDTA, 15 parts of sodium chloride, 20 parts of glycerin, 10 parts of sodium hyaluronate, 7 parts of camellia seed oil, 40 parts of horse fat, 10 parts of silk hydrolysate, 0.3 part of essence and 1 part of citric acid.

The traditional Chinese medicine shampoo for treating hair/scalp diseases is prepared by the following method, but not limited to, the method comprises the following steps:

s1: the preparation of the main drug comprises respectively carrying out superfine grinding on each component of the traditional Chinese medicine composition for 30s, sieving with a 150-mesh sieve, and mixing for 30min according to the corresponding weight parts to obtain traditional Chinese medicine powder. Dissolving 1 part by weight of natural gelatin in 120 parts by weight of deionized refined water, heating in a circulating water bath at 60 ℃, stirring at 300rpm, adding 90 parts by weight of traditional Chinese medicine powder, adding 10 parts by weight of tween-20, emulsifying for 10min, adding 5 parts by weight of sodium sulfate solution, stirring for 30min, transferring to a cold water bath, stirring at 300rpm, adding 4 parts by weight of glutaraldehyde, crosslinking and curing for 3h, standing for 1h, centrifuging at 1000rpm, washing the precipitate with isopropanol for 6 times, filtering, and drying to obtain particles, namely the main drug, for later use;

s2: preparation of dispersion liquid: the respective components in the dispersion liquid were dissolved in 100 parts by weight of deionized purified water according to the respective parts by weight, homogenized for 120 seconds at 2000rpm of a homogenizer, and repeated 1 time to obtain a dispersion liquid.

S3: the dispersion obtained in S2 and the base drug obtained in S1 were mixed in a vertical mixer, and the mixture was stirred at 60rpm for 60min at 20 ℃.

Example 8:

the traditional Chinese medicine shampoo for treating hair/scalp diseases comprises a dispersion liquid and a main medicine; the main medicine contains the traditional Chinese medicine composition in the embodiment 5. The dispersion comprises the following components in parts by weight: taking 10 parts of sodium laureth sulfate, 15 parts of cocamidopropyl betaine, 30 parts of cocamide DEA, 2 parts of polyquaternium-10, 0.3 part of sodium benzoate, 2 parts of EDTA tetrasodium, 10 parts of sodium chloride, 15 parts of glycerol, 20 parts of sodium hyaluronate, 5 parts of camellia seed oil, 30 parts of horse fat, 20 parts of silk hydrolysate, 0.1 part of essence and 0.6 part of citric acid.

s1: the preparation of the main drug comprises respectively carrying out superfine grinding on each component of the traditional Chinese medicine composition for 90s, sieving with a 40-mesh sieve, and mixing for 18min according to the corresponding weight parts to obtain traditional Chinese medicine powder. Dissolving 10 parts by weight of natural gelatin in 20 parts by weight of deionized refined water, heating in a circulating water bath at 50 ℃, stirring at 1500rpm, adding 10 parts by weight of traditional Chinese medicine powder, adding 5 parts by weight of tween-20, emulsifying for 50min, adding 1 part by weight of sodium sulfate solution, stirring for 20min, transferring to a cold water bath, stirring at 1500rpm, adding 1 part by weight of glutaraldehyde, crosslinking and curing for 1h, standing for 5h, centrifuging at 500rpm, washing the precipitate with isopropanol for 2 times, filtering, and drying to obtain particles, namely the main drug, for later use;

s2: preparation of dispersion liquid: the respective components in the dispersion liquid were dissolved in 1000 parts by weight of deionized purified water according to the respective parts by weight, homogenized for 100s at 1000rpm of a homogenizer, and repeated 5 times to obtain a dispersion liquid.

S3: the dispersion obtained in S2 and the base drug obtained in S1 were mixed in a vertical mixer, and the mixture was stirred at 10rpm for 30min at 20 ℃.

Example 9:

the traditional Chinese medicine shampoo for treating hair/scalp diseases comprises a dispersion liquid and a main medicine; the main medicine contains the traditional Chinese medicine composition in the embodiment 6. The dispersion comprises the following components in parts by weight: taking 60 parts of sodium laureth sulfate, 10 parts of cocamidopropyl betaine, 20 parts of cocamide DEA, 10 parts of polyquaternium-10, 0.1 part of sodium benzoate, 1 part of tetrasodium EDTA, 20 parts of sodium chloride, 10 parts of glycerol, 15 parts of sodium hyaluronate, 10 parts of camellia seed oil, 20 parts of horse fat, 15 parts of silk hydrolysate, 0.5 part of essence and 0.1 part of citric acid.

s1: the preparation of the main drug comprises respectively micronizing the components of the traditional Chinese medicine composition for 50s, sieving with a 200-mesh sieve, and mixing according to the corresponding weight parts for 10min to obtain traditional Chinese medicine powder. Dissolving 5 parts by weight of natural gelatin in 300 parts by weight of deionized refined water, heating in a circulating water bath at 30 ℃, stirring at 1000rpm, adding 150 parts by weight of traditional Chinese medicine powder, adding 1 part by weight of tween-20, emulsifying for 35min, adding 10 parts by weight of sodium sulfate solution, stirring for 10min, transferring to a cold water bath, stirring at 800rpm, adding 10 parts by weight of glutaraldehyde, performing crosslinking and curing for 0.5h, standing for 3h, centrifuging at 2500rpm, taking out precipitate, washing 1 time with isopropanol, filtering, and drying to obtain particles, namely main drugs, for later use;

s2: preparation of dispersion liquid: the components in the dispersion are dissolved in 500 parts by weight of deionized purified water according to the corresponding parts by weight, and the mixture is homogenized for 30s at 3000rpm of a homogenizer and repeated for 3 times to obtain the dispersion.

S3: the dispersion obtained in S2 and the base drug obtained in S1 were mixed in a vertical mixer, and the mixture was stirred at 100rpm for 10min at 40 ℃.

The reliability and safety of the Chinese medicinal composition for treating hair/scalp diseases produced in examples 7 to 9 of the present invention are tested to completely meet the requirements of the national relevant standards.

In order to further examine the clinical efficacy of the traditional Chinese medicine shampoo, 100 outpatients are selected for clinical tests, and the traditional Chinese medicine shampoo is used for treating alopecia, and the specific method and the result are as follows:

clinical treatment examples:

1. diagnostic criteria

Refer to the relevant standards in "dermatology of traditional Chinese medicine".

Removing genetic tendency, and giving priority to weak or excessive mental;

② the hair is thin, thin and soft, and can be shed for a long time or even bald, the skin of the bald area is smooth, and the fine vellus hairs can be seen;

thirdly, the symptoms such as dizziness, insomnia, poor memory, soreness and weakness of waist and knees, tinnitus, dysphoria with smothery sensation in chest, palms and soles and the like are accompanied;

fourthly, the tongue is red, the coating is little, and the pulse is thready and rapid.

2. Inclusion criteria

Meeting the diagnosis standard;

② the age is 20-65 years old;

③ the course of disease is within 5 years;

and fourthly, voluntarily receiving the test and signing an informed consent.

3. Exclusion criteria

Firstly, the Chinese and western medicines for treating the disease and other medicines which can interfere the hair growth are taken within nearly 6 months;

② patients with liver and kidney insufficiency and serious diseases accompanied with other systems;

③ patients with alopecia caused by other reasons (such as endocrine diseases such as polycystic ovary syndrome, alopecia areata, congenital alopecia totalis or congenital alopecia paucity, traumatic alopecia, chemotherapy, etc.);

women in gestation period, preparatory pregnancy, 12 months or lactation period after delivery and psychopaths;

fifthly, for those allergic to the test drugs.

4. Standard of detachment

Firstly, the medicine is not taken according to the regulation, the compliance is poor, and the judgment of the curative effect is influenced;

② incomplete test data;

finding a pregnant person during the test period;

and fourthly, the laboratory index is abnormal or other adverse events occur during the test period, and the tester can not continue the test.

5. Clinical sample size

Eligible patients were selected, with a total of 100 clinical samples of the product per example, and 50 men and women within the age range.

6. Application method

The hair loss on the pillow when getting up every day for one week and the hair loss when washing hair each time before the administration of the medicine is started are recorded. The application method comprises washing hair with the shampoo once a day, applying the kneaded foam to the hair every time, massaging for two to five minutes, and washing. One course of treatment is seven days, the alopecia amount is recorded every day after the application, and statistics is carried out once every seven days, and the treatment is carried out for five courses in total.

7. Standard of therapeutic effect

Has obvious effect (the average hair loss amount of each course of treatment after treatment is reduced by more than 50 percent compared with that before treatment, new hair grows out in the hair loss area, and patients and doctors are satisfied);

effective (the average hair loss amount of each course of treatment after treatment is reduced by 20-50% compared with that before treatment, and patients and doctors consider the condition of the disease to be improved);

ineffectiveness (the average hair loss per treatment course after treatment is reduced by less than 20% compared with that before treatment, the treatment effect of patients is unsatisfactory)

8. Therapeutic results

(1) The results of use: after the medicament is used, 18 cases are effective, 62 cases are effective, 20 cases are ineffective, and the total effective rate is 80%.

(2) New hair growth time: in the effective case of statistical observation, the patients can be found in different time periods after the medicines are taken within 0-7 days: the amount of hair loss of the patients starts to decrease, the amount of hair loss of the patients is greatly decreased in 7-15 days, the hairs are slightly blackened, the amount of hair loss of the patients is further decreased in 15-30 days, the hairs are partially thickened, and the hairs are blackened.

(3) The side effect is shown as follows: the side effect of 100 patients in the treatment process is counted, and no obvious adverse reaction occurs in the treatment group.

The results show that the traditional Chinese medicine shampoo disclosed by the invention is used for treating alopecia, has the advantages of quick response, short treatment course, high cure rate, no side effect and the like, and is worthy of clinical popularization and application.

The curative effect of the traditional Chinese medicine shampoo is further verified through specific cases as follows:

case 1

According to the traditional Chinese medicine shampoo, old men and 39 years old have high hairline and serious alopecia, and can be recommended by people to see a doctor from our places. 807 +/-284 hair losses of patients in one week before treatment, 612 +/-258 hair losses in the first course, 502 +/-225 hair losses in the second course, 343 +/-199 hair losses in the third course, 289 +/-166 hair losses in the fourth course, 173 +/-152 hair losses in the fifth course, 384 total average hair losses in the first course, and the hair loss reduction amount accounts for 52.4 percent of the hair loss amount before treatment. It can be seen that the amount of hair loss per treatment course is reduced in the patients, and the total average hair loss reduction is at a significant level. Meanwhile, a small amount of white vellus hairs begin to appear at the hairline after 30 days of use, and the hairs are thicker.

Case 2

Zhangqi, female, 55 years old, patients have white hair and serious alopecia, other anti-alopecia products have been tried, no obvious effect exists, and the traditional Chinese medicine shampoo is recommended to be used for treatment in our places. 906 +/-168 hair loss of a patient in one week before treatment, 734 +/-239 hair loss in the first treatment course, 577 +/-211 hair loss in the second treatment course, 396 +/-261 hair loss in the third treatment course, 321 +/-124 hair loss in the fourth treatment course, 196 +/-154 hair loss in the fifth treatment course, and the total average hair loss amount 445 in the treatment courses, wherein the hair loss reduction amount accounts for 50.9 percent of the hair loss amount before treatment. It can be seen that the amount of hair loss per treatment course is reduced in the patients, and the total average hair loss reduction is at a significant level. And the hair quality of the patient begins to gradually become black after 30 days of use, and the hair quality is improved.

Case 3

Zhao, a woman in age of 40, patients have sparse hair and serious alopecia, and the traditional Chinese medicine shampoo is used when the doctor recommends to see a doctor in our place. 816 +/-234 alopecia of patients in one week before treatment, 602 +/-208 alopecia in the first course, 421 +/-175 alopecia in the second course, 293 +/-149 alopecia in the third course, 223 +/-116 alopecia in the fourth course, 121 +/-102 alopecia in the fifth course, 332 alopecia in the total average alopecia amount in the first course, and the alopecia reduction amount accounts for 59.3% of the alopecia amount before treatment. It can be seen that the amount of hair loss per treatment course is reduced in the patients, and the total average hair loss reduction is at a significant level. Meanwhile, a small amount of white vellus hairs begin to grow at the sparse part after the hair is used for 30 days, the hairs are thicker, the whole person feels full of vitality, and the effect is obvious.

In order to further examine the clinical efficacy of the traditional Chinese medicine shampoo for removing dandruff, 40 outpatients are selected for clinical tests, and the traditional Chinese medicine shampoo is used for treating dandruff, and the specific method and the result are as follows:

1. test object

40 patients with dandruff of 25-50 years old are selected, randomly divided into 4 groups of 10 people each, and taken as the trial population of the embodiment.

2. Method of treatment

The traditional Chinese medicine shampoo disclosed by the invention is respectively used in 4 experimental groups, and the using methods are as follows: the hair is washed by the shampoo once a day, the amount of the kneaded foam is preferably used for coating the hair every time, and the hair is washed off after massaging for two to five minutes. One course of treatment is one week, four courses of treatment are performed in total, and the application process is followed.

3. Criteria for therapeutic effect

And (3) healing: scurf disappears, and no pruritus is caused;

the method has the following advantages: dandruff is reduced, and pruritus disappears;

and (4) invalidation: little or no change in dandruff and little or no change in itching.

4. Effects of use

After 4 weeks of use, 4 groups of subjects were evaluated for efficacy and the results showed: 17 out of 40 patients were cured (cure rate 42.5%), 23 patients were effective (effective rate 57.5%), and the number of ineffective patients was zero.

The experiment also required 40 panelists to rate the antidandruff effect, antipruritic effect and easy combing degree of hair of the antidandruff composition of the present invention in a sensory evaluation manner, wherein: the dandruff removing effect is graded according to the amount and the size of dandruff, the itching relieving effect is graded according to the duration time of the scalp itching and the scalp itching degree, and the hair combing easiness degree is graded according to the combing difficulty degree of the dried hair; the evaluation adopts a score of 5, the score of 5 is the highest score, the score of 1 is the lowest score, and the higher the score is, the better the effect is represented.

Evaluation index	Anti-dandruff effect	Antipruritic effect	Easy combing effect
				Score of	4.5	4.0	4.5

Therefore, the traditional Chinese medicine composition has a good effect of treating dandruff.

III specific example of Chinese medicinal hair mask:

example 10: the traditional Chinese medicine hair mask for treating hair/scalp diseases comprises a dispersion liquid and a main medicine containing a traditional Chinese medicine composition, wherein the traditional Chinese medicine composition comprises the following components in parts by weight: 1 part of rhizoma drynariae and 15 parts of salt.

The dispersion comprises the following components in parts by weight: 0.3 part of sodium benzoate, 0.7 part of EDTA tetrasodium, 11 parts of glycerin, 11 parts of sodium hyaluronate, 6 parts of camellia seed oil, 22 parts of horse fat, 12 parts of silk hydrolysate, 0.2 part of essence and 0.7 part of citric acid.

Example 11: the traditional Chinese medicine hair mask for treating hair/scalp diseases comprises a dispersion liquid and a main medicine containing a traditional Chinese medicine composition, wherein the traditional Chinese medicine composition comprises the following components in parts by weight: 16 parts of rhizoma drynariae and 2 parts of salt.

The dispersion comprises the following components in parts by weight: 0.2 part of sodium benzoate, 0.5 part of EDTA tetrasodium, 10 parts of glycerin, 10 parts of sodium hyaluronate, 5 parts of camellia seed oil, 20 parts of horse fat, 10 parts of silk hydrolysate, 0.1 part of essence and 0.1 part of citric acid.

Example 12: the traditional Chinese medicine hair mask for treating hair/scalp diseases comprises a dispersion liquid and a main medicine containing a traditional Chinese medicine composition, wherein the traditional Chinese medicine composition comprises the following components in parts by weight: 15 parts of rhizoma drynariae, 8 parts of salt, 5 parts of fructus viticis, 3 parts of pine needles, 3 parts of rhizoma cimicifugae, 5 parts of radix sileris and 3 parts of mulberry leaves.

The dispersion comprises the following components in parts by weight: 0.4 part of sodium benzoate, 0.9 part of EDTA tetrasodium, 17 parts of glycerin, 16 parts of sodium hyaluronate, 8 parts of camellia seed oil, 35 parts of horse fat, 18 parts of silk hydrolysate, 0.5 part of essence and 1 part of citric acid.

Example 13:

the traditional Chinese medicine hair mask for treating hair/scalp diseases comprises a dispersion liquid and a main medicine containing a traditional Chinese medicine composition, wherein the traditional Chinese medicine composition comprises the following components in parts by weight: 5 parts of rhizoma drynariae, 5 parts of salt, 5 parts of fructus viticis, 3 parts of pine needle, 3 parts of rhizoma cimicifugae, 5 parts of radix sileris and 3 parts of mulberry leaf.

The preparation method of the traditional Chinese medicine hair mask for treating hair/scalp diseases comprises the following steps:

s1: preparation of main drugs: respectively micronizing the components of the Chinese medicinal composition for 30s, sieving with 40 mesh sieve to obtain powder of each component, and mixing for 10min according to the corresponding weight parts to obtain Chinese medicinal powder; dissolving 3 parts by weight of glucomannan in 20 parts by weight of deionized refined water, heating in a circulating water bath at 30 ℃, stirring at 300rpm, adding 10 parts by weight of traditional Chinese medicine powder, adding 3 parts by weight of tween-20, emulsifying for 10min, adding 3 parts by weight of sodium sulfate solution, stirring for 10min, transferring to a water bath at 0 ℃ at 300rpm, stirring, adding 3 parts by weight of glutaraldehyde, crosslinking and curing for 1h, standing for 1h, centrifuging at 500rpm, taking out precipitate, washing for 2 times with isopropanol, filtering, drying to obtain particles, namely the main drug, for later use;

s2: preparing a dispersion liquid: dissolving the sodium benzoate, EDTA tetrasodium, glycerol, sodium hyaluronate, camellia seed oil, horse fat, silk hydrolysate, essence and citric acid in the corresponding weight parts in 500 parts of deionized refined water, homogenizing at 1500rpm for 30s, and repeating for 2 times to obtain the dispersion.

S3: the dispersion obtained in S2 and the base drug obtained in S1 were mixed in a vertical mixer and stirred at 50rpm for 20 min.

Example 14:

the traditional Chinese medicine hair mask for treating hair/scalp diseases comprises a dispersion liquid and a main medicine containing a traditional Chinese medicine composition, wherein the traditional Chinese medicine composition comprises the following components in parts by weight: 10 parts of rhizoma drynariae, 10 parts of salt, 10 parts of fructus viticis, 5 parts of pine needles, 5 parts of rhizoma cimicifugae, 10 parts of radix sileris and 5 parts of mulberry leaves.

s1: preparation of main drugs: respectively micronizing the components of the Chinese medicinal composition for 50s, sieving with 80 mesh sieve to obtain powder of each component, and mixing for 20min according to the above corresponding weight parts to obtain Chinese medicinal powder; dissolving 5 parts by weight of glucomannan in 100 parts by weight of deionized refined water, heating in a circulating water bath at 40 ℃, stirring at 600rpm, adding 50 parts by weight of traditional Chinese medicine powder, adding 5 parts by weight of tween-20, emulsifying for 30min, adding 5 parts by weight of sodium sulfate solution, stirring for 20min, transferring to a water bath at 3 ℃ at 600rpm, stirring, adding 5 parts by weight of glutaraldehyde, crosslinking and curing for 1h, standing for 2h, centrifuging at 1500rpm, taking out precipitate, washing with isopropanol for 3 times, filtering, and drying to obtain particles, namely the main drug, for later use;

s2: preparing a dispersion liquid: dissolving the sodium benzoate, EDTA tetrasodium, glycerol, sodium hyaluronate, camellia seed oil, horse fat, silk hydrolysate, essence and citric acid in the corresponding weight parts in 800 parts of deionized refined water, homogenizing at 2000rpm for 80s with a homogenizer, and repeating for 3 times to obtain the dispersion.

S3: the dispersion obtained in S2 and the base drug obtained in S1 were mixed in a vertical mixer and stirred at 65rpm for 30 min.

Example 15:

the traditional Chinese medicine hair mask for treating hair/scalp diseases comprises a dispersion liquid and a main medicine containing a traditional Chinese medicine composition, wherein the traditional Chinese medicine composition comprises the following components in parts by weight: 16 parts of rhizoma drynariae, 16 parts of salt, 16 parts of fructus viticis, 9 parts of pine needles, 9 parts of rhizoma cimicifugae, 16 parts of divaricate saposhnikovia root and 9 parts of mulberry leaves.

s1: preparation of main drugs: respectively micronizing the components of the Chinese medicinal composition for 90s, sieving with 100 mesh sieve to obtain powder of each component, and mixing for 30min according to the above corresponding weight parts to obtain Chinese medicinal powder; dissolving 9 parts by weight of glucomannan in 300 parts by weight of deionized refined water, heating in a circulating water bath at 50 ℃, stirring at 1500rpm, adding 150 parts by weight of traditional Chinese medicine powder, adding 9 parts by weight of tween-20, emulsifying for 50min, adding 9 parts by weight of sodium sulfate solution, stirring for 30min, transferring to a water bath at 4 ℃, stirring at 1500rpm, adding 9 parts by weight of glutaraldehyde, crosslinking and curing for 2h, standing for 2h, centrifuging at 2500rpm, taking out precipitate, washing with isopropanol for 5 times, filtering, and drying to obtain particles, namely the main drug, for later use;

s2: preparing a dispersion liquid: dissolving the sodium benzoate, EDTA tetrasodium, glycerol, sodium hyaluronate, camellia seed oil, horse fat, silk hydrolysate, essence and citric acid in 1000 parts by weight in deionized refined water, homogenizing at 3000rpm for 120s, and repeating for 5 times to obtain the dispersion.

S3: the dispersion obtained in S2 and the base drug obtained in S1 were mixed in a vertical mixer and stirred at 100rpm for 60 min.

Example 16:

the traditional Chinese medicine hair mask for treating hair/scalp diseases comprises a dispersion liquid and a main medicine containing a traditional Chinese medicine composition, wherein the traditional Chinese medicine composition comprises the following components in parts by weight: 1 part of rhizoma drynariae, 1 part of salt, 1 part of fructus viticis, 1 part of pine needle, 1 part of cimicifugae foetidae, 1 part of radix sileris and 1 part of mulberry leaf.

The dispersion comprises the following components in parts by weight: 0.1 part of sodium benzoate, 0.5 part of EDTA tetrasodium, 10 parts of glycerin, 10 parts of sodium hyaluronate, 5 parts of camellia seed oil, 20 parts of horse fat, 10 parts of silk hydrolysate, 0.1 part of essence and 0.1 part of citric acid.

s1: preparation of main drugs: respectively micronizing the components of the Chinese medicinal composition for 30s, sieving with 40 mesh sieve to obtain powder of each component, and mixing for 10min according to the corresponding weight parts to obtain Chinese medicinal powder; dissolving 1 weight part of glucomannan in 20 weight parts of deionized refined water, heating in a circulating water bath at 30 ℃, stirring at 300rpm, adding 10 weight parts of traditional Chinese medicine powder, adding 1 weight part of tween-20, emulsifying for 10min, adding 1 weight part of sodium sulfate solution, stirring for 10min, transferring to a water bath at 0 ℃ at 300rpm, stirring, adding 1 weight part of glutaraldehyde, crosslinking and curing for 0.5h, standing for 1h, centrifuging at 500rpm, taking precipitate, washing with isopropanol for 1 time, filtering, and drying to obtain particles, namely the main drug, for later use;

s2: preparing a dispersion liquid: dissolving the sodium benzoate, EDTA tetrasodium, glycerol, sodium hyaluronate, camellia seed oil, horse fat, silk hydrolysate, essence and citric acid in 100 weight parts in deionized refined water, homogenizing at 1000rpm for 30s, and repeating for 1 time to obtain the dispersion.

S3: the dispersion obtained in S2 and the base drug obtained in S1 were mixed in a vertical mixer and stirred at 10rpm for 10 min.

Example 17:

the traditional Chinese medicine hair mask for treating hair/scalp diseases comprises a dispersion liquid and a main medicine containing a traditional Chinese medicine composition, wherein the traditional Chinese medicine composition comprises the following components in parts by weight: 20 parts of rhizoma drynariae, 20 parts of salt, 20 parts of fructus viticis, 10 parts of pine needles, 10 parts of rhizoma cimicifugae, 20 parts of radix sileris and 10 parts of mulberry leaves.

The dispersion comprises the following components in parts by weight: 0.5 part of sodium benzoate, 2 parts of EDTA tetrasodium, 20 parts of glycerin, 20 parts of sodium hyaluronate, 10 parts of camellia seed oil, 40 parts of horse fat, 20 parts of silk hydrolysate, 0.5 part of essence and 1 part of citric acid.

s1: preparation of main drugs: respectively micronizing the components of the Chinese medicinal composition for 90s, sieving with 200 mesh sieve to obtain powder of each component, and mixing for 30min according to the above corresponding weight parts to obtain Chinese medicinal powder; dissolving 10 parts by weight of glucomannan in 300 parts by weight of deionized refined water, heating in a circulating water bath at 60 ℃, stirring at 1500rpm, adding 150 parts by weight of traditional Chinese medicine powder, adding 10 parts by weight of tween-20, emulsifying for 50min, adding 10 parts by weight of sodium sulfate solution, stirring for 30min, transferring to a water bath at 4 ℃, stirring at 1500rpm, adding 10 parts by weight of glutaraldehyde, crosslinking and curing for 3h, standing for 5h, centrifuging at 2500rpm, taking out precipitate, washing with isopropanol for 6 times, filtering, and drying to obtain particles, namely the main drug, for later use;

Example 18:

the traditional Chinese medicine hair mask for treating hair/scalp diseases comprises a dispersion liquid and a main medicine containing a traditional Chinese medicine composition, wherein the traditional Chinese medicine composition comprises the following components in parts by weight: 20 parts of rhizoma drynariae, 1 part of salt, 20 parts of fructus viticis, 1 part of pine needle, 10 parts of rhizoma cimicifugae, 1 part of radix sileris and 10 parts of mulberry leaf.

The dispersion comprises the following components in parts by weight: 0.1 part of sodium benzoate, 2 parts of EDTA tetrasodium, 10 parts of glycerin, 20 parts of sodium hyaluronate, 5 parts of camellia seed oil, 40 parts of horse fat, 10 parts of silk hydrolysate, 0.5 part of essence and 0.1 part of citric acid.

s1: preparation of main drugs: respectively micronizing the components of the Chinese medicinal composition for 90s, sieving with 40 mesh sieve to obtain powder of each component, and mixing according to the above corresponding weight parts for 30min to obtain Chinese medicinal powder; dissolving 1 part by weight of glucomannan in 300 parts by weight of deionized refined water, heating in a circulating water bath at 30 ℃, stirring at 1500rpm, adding 10 parts by weight of traditional Chinese medicine powder, adding 10 parts by weight of tween-20, emulsifying for 10min, adding 10 parts by weight of sodium sulfate solution, stirring for 10min, transferring to a water bath at 4 ℃ at 300rpm, stirring, adding 10 parts by weight of glutaraldehyde, crosslinking and curing for 0.5h, standing for 5h, centrifuging at 500rpm, taking out precipitate, washing with isopropanol for 6 times, filtering, and drying to obtain particles, namely the main drug, for later use;

s2: preparing a dispersion liquid: dissolving the sodium benzoate, EDTA tetrasodium, glycerol, sodium hyaluronate, camellia seed oil, horse fat, silk hydrolysate, essence and citric acid in 100 weight parts in deionized refined water, homogenizing at 3000rpm for 30s, and repeating for 5 times to obtain the dispersion.

S3: the dispersion obtained in S2 and the base drug obtained in S1 were mixed in a vertical mixer and stirred at 10rpm for 60 min.

The reliability and safety of the traditional Chinese medicine hair mask for treating hair/scalp diseases in the embodiments 10 to 18 of the invention are detected to completely meet the requirements of the national relevant standards.

In order to further examine the clinical efficacy of the traditional Chinese medicine hair mask, 100 outpatients are selected for clinical tests, and the traditional Chinese medicine hair mask is used for clinically treating alopecia, and the specific method and the result are as follows:

clinical treatment examples:

8. diagnostic criteria

Fifthly, removing genetic tendency, and giving priority to weak or over-mental patients;

sixthly, the hair is thin and soft, and can fall off for a long time or even bald, the skin of the alopecia area is smooth, and the fine vellus hairs can be seen;

seventhly, accompanied by symptoms such as vertigo, insomnia, poor memory, soreness and weakness of waist and knees, tinnitus, dysphoria with smothery sensation in chest, and the like;

red tongue with little coating and thready and rapid pulse.

9. Inclusion criteria

Fifth, the diagnostic standard is met;

sixthly, the age is 20 to 65 years old;

the disease course is within 5 years;

and the host computer signs an informed consent to voluntarily test.

10. Exclusion criteria

Sixthly, the Chinese and western medicines for treating the disease and other medicines which can interfere the hair growth are taken within about 6 months;

seventhly, patients with liver and kidney insufficiency and serious diseases accompanied with other systems;

eighthly, alopecia patients caused by other reasons (such as endocrine diseases such as polycystic ovary syndrome, alopecia areata, congenital alopecia totalis or congenital alopecia paucity, traumatic alopecia, chemotherapy and the like);

ninthly women in pregnancy, preparatory pregnancy, 12 months or lactation period after delivery, and psychopath;

those allergic to test drugs.

11. Standard of detachment

Fifthly, the medicine is not taken according to the regulations, the compliance is poor, and the judgment of the curative effect is influenced;

sixthly, the test data is incomplete;

seventhly, during the test period, a pregnant person is found;

and during the test period, the laboratory index is abnormal or other adverse events occur, and the tester can not continue the test.

12. Clinical sample size

13. Application method

The amount of hair falling off from the pillow when getting up every day a week immediately before the start of the medication and the amount of hair falling off each time of shampooing were recorded. The medicine is applied to the hair uniformly after the hair is washed out each time, and the scalp is massaged for two to five minutes and then washed out. One course of treatment is seven days, the alopecia amount is recorded every day after the application, and statistics is carried out once every seven days, and the treatment is carried out for five courses in total.

14. Standard of therapeutic effect

8. Therapeutic results

(1) The results of use: after the medicine is used, 23 cases are effective, 67 cases are effective, 10 cases are ineffective, and the total effective rate is 90%.

(2) New hair growth time: in the effective case of statistical observation, the patients can be found in different time periods after the medicines are taken within 0-7 days: the amount of hair loss of patients begins to decrease, the amount of hair loss of patients is greatly decreased in 7-15 days, the hair is slightly blackened, the amount of hair loss of patients is further decreased in 15-30 days, the hair part is thickened, and the hair quality is improved.

The results show that the traditional Chinese medicine hair mask provided by the invention is used for treating alopecia, has the advantages of quick effect, short treatment course, high cure rate, no side effect and the like, and is worthy of clinical popularization and application.

The Chinese medicine hair mask curative effect of the invention is further verified by specific cases as follows:

case 4

Zhangzhi, male, age 44, the patient suffers from wind, sunshine and the like because of working outdoors for a long time, and gradually appears the conditions of sparse hair, yellow white and not black. The Chinese medicinal hair mask is used for treating 712 +/-272 hair loss in a first course of treatment, 478 +/-120 hair loss in a second course of treatment, 311 +/-117 hair loss in a third course of treatment, 215 +/-101 hair loss in a fourth course of treatment, 111 +/-106 hair loss in a fifth course of treatment, 366 total average hair loss in the course of treatment and 62.1% of hair loss reduction amount in the hair loss amount before treatment. The hair loss amount of each treatment course is reduced, a small amount of white vellus hairs begin to grow at the hairline after the hair is used, the scalp becomes black, the hair quality begins to gradually turn black, and the effect is obvious.

Case 5

Zhao, male, 48 years old, the patient began to lose hair 1 year ago, began to fall off locally, and later became more serious, because of the loss of hair, the patient's mood was lowered, the patient was frustrated with confidence, and the obvious effect was not seen with various anti-hair loss shampoos. Through recommendation, the traditional Chinese medicine hair mask disclosed by the invention is used for treating 889 +/-124 hair loss of a patient in one week before treatment, 733 +/-112 hair loss in the first treatment course, 435 +/-110 hair loss in the second treatment course, 280 +/-136 hair loss in the third treatment course, 221 +/-136 hair loss in the fourth treatment course, 132 +/-123 hair loss in the fifth treatment course, the total average hair loss amount of 360 hair loss in the treatment courses, and the hair loss reduction amount accounts for 59.5% of the hair loss amount before treatment. It can be seen that the hair loss amount is reduced in each course of treatment, and the total average hair loss reduction amount is at a significant level. After the hair-blackening cream is used, large-piece white vellus hairs grow on the head of a patient, the scalp becomes black, and the mental state is obviously improved.

Case 6

Liu is certain, female is 51 years old, hair of a patient is sparse, hair loss is serious, the patient suffers from depression and depression due to the hair loss, vexation and qi dryness, and the hair loss treatment by using various anti-hair loss shampoos and Chinese and western medicines does not have obvious effect. The doctor visits our places by recommendation. 936 +/-724 alopecia of patients before use, 698 +/-124 alopecia in the first treatment course, 413 +/-134 alopecia in the second treatment course, 286 +/-112 alopecia in the third treatment course, 196 +/-124 alopecia in the fourth treatment course, 136 +/-119 alopecia in the fifth treatment course, 346 total average alopecia amount in the treatment courses and 63.1% alopecia decrement in the alopecia amount before treatment after the traditional Chinese medicine hair mask is used. It can be seen that the hair loss per treatment period is reduced, and the total average hair loss reduction is at a significant level. Meanwhile, white vellus hairs emerge from the sparse part of the patient hair after the use, the hair is thicker, the mental state of the patient is obviously improved, and the effect is obvious.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims

1. A traditional Chinese medicine composition for treating hair/scalp diseases is characterized by comprising the following components: rhizoma Drynariae and salt.

2. The Chinese medicinal composition for treating hair/scalp disorders according to claim 1, further comprising one or a combination of two or more of the following components: radix Saposhnikoviae, folium Mori, fructus Vitics Simplicifoliae, folium Pini and cimicifugae rhizoma.

3. The traditional Chinese medicine composition for treating hair/scalp disorders according to claim 2, comprising the following components in parts by weight: 1-20 parts of rhizoma drynariae, 1-20 parts of salt, 1-20 parts of divaricate saposhnikovia root, 1-10 parts of mulberry leaf, 1-20 parts of fructus viticis, 1-10 parts of pine needle and 1-10 parts of cimicifugae foetidae.

4. A traditional Chinese medicine shampoo for treating hair/scalp diseases is characterized by comprising a dispersion and a main medicine containing the traditional Chinese medicine composition as claimed in any one of claims 1 to 3, wherein the dispersion comprises a surfactant, alcohols and water.

5. The traditional Chinese medicine shampoo for treating hair/scalp diseases according to claim 4, characterized in that: the main drug is particles prepared by embedding the traditional Chinese medicine composition with gelatin.

6. The traditional Chinese medicine shampoo for treating hair/scalp diseases according to claim 4, characterized in that: the main drug is particles prepared by embedding the traditional Chinese medicine composition according to the following components in parts by weight, 1-10 parts of gelatin, 20-300 parts of water, 1-10 parts of emulsifier, 1-10 parts of coagulant and 1-10 parts of cross-linking agent.

7. The traditional Chinese medicine shampoo for treating hair/scalp diseases according to claim 4, characterized in that: the surfactant comprises one or the combination of more than two of the following components of sodium laureth sulfate, cocamidopropyl betaine, cocamide DEA and polyquaternium-10.

8. The traditional Chinese medicine shampoo for treating hair/scalp diseases according to claim 4, characterized in that: the dispersion also comprises camellia seed oil, horse fat, arginine and silk hydrolysate.

9. The preparation method of the traditional Chinese medicine shampoo for treating the hair/scalp diseases according to claim 4, which is characterized by comprising the following steps of:

s3: and uniformly stirring the particles in the S1 and the dispersion liquid in the S2 to obtain the traditional Chinese medicine shampoo.

10. The method for preparing the traditional Chinese medicine shampoo for treating hair/scalp diseases according to claim 9, wherein in step S1, the method for embedding the microparticles comprises the following steps: dissolving 1-10 parts of gelatin in 20-300 parts of water, heating at 30-60 ℃, adding 10-150 parts of traditional Chinese medicine powder, adding 1-10 parts of emulsifier for emulsification for 10-50 min, adding 1-10 parts of coagulant solution, stirring for 10-30 min, transferring to 0-4 ℃ water bath for stirring at 300-1500 rpm, adding 1-10 parts of cross-linking agent for cross-linking and curing for 0.5-3 h, standing for 1-5 h, centrifuging at 500-2500 rpm, and taking precipitate to obtain particles; in step S3, the particles are mixed with the dispersion liquid and stirred at 10-100 rpm for 10-60 min.

11. A Chinese medicinal hair mask for treating hair/scalp diseases, which comprises a dispersion and a main ingredient containing the Chinese medicinal composition of any one of claims 1 to 3.

12. The traditional Chinese medicine hair mask for treating hair/scalp diseases according to claim 11, characterized in that: the main drug is particles prepared by embedding a traditional Chinese medicine composition with glucomannan.

13. A Chinese medicinal composition for treating hair/scalp disorders according to any one of claims 1 to 3, characterized in that: the hair/scalp disorders include alopecia or/and dandruff.