CN112773748A - Traditional Chinese medicine shampoo for treating seborrheic alopecia and application thereof - Google Patents

Traditional Chinese medicine shampoo for treating seborrheic alopecia and application thereof Download PDF

Info

Publication number
CN112773748A
CN112773748A CN202110265621.2A CN202110265621A CN112773748A CN 112773748 A CN112773748 A CN 112773748A CN 202110265621 A CN202110265621 A CN 202110265621A CN 112773748 A CN112773748 A CN 112773748A
Authority
CN
China
Prior art keywords
parts
traditional chinese
chinese medicine
alopecia
medicine shampoo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202110265621.2A
Other languages
Chinese (zh)
Inventor
刘津津
杨子琦
李飞鸿
袁坪晖
张泽豪
覃燕新
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Guangzhou Wenhui Pharmaceutical Technology Co ltd
Original Assignee
Guangzhou Wenhui Pharmaceutical Technology Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guangzhou Wenhui Pharmaceutical Technology Co ltd filed Critical Guangzhou Wenhui Pharmaceutical Technology Co ltd
Priority to CN202110265621.2A priority Critical patent/CN112773748A/en
Publication of CN112773748A publication Critical patent/CN112773748A/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34Alcohols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9755Gymnosperms [Coniferophyta]
    • A61K8/9761Cupressaceae [Cypress family], e.g. juniper or cypress
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/987Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/04Antipruritics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/08Antiseborrheics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/14Drugs for dermatological disorders for baldness or alopecia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005Antimicrobial preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00Preparations for affecting hair growth
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • A61K2800/5922At least two compounds being classified in the same subclass of A61K8/18

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Emergency Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Cosmetics (AREA)

Abstract

The invention belongs to the technical field of daily chemical products, and particularly relates to traditional Chinese medicine shampoo for treating seborrheic alopecia and application thereof. The active ingredients of the traditional Chinese medicine shampoo for treating seborrheic alopecia comprise the following raw materials in parts by mass: 20-100 parts of tea seed cake, 10-100 parts of cacumen biotae, 20-80 parts of chrysanthemum morifolium, 20-80 parts of cynanchum paniculatum, 20-80 parts of honeysuckle, 2-40 parts of liquorice, 2-30 parts of angelica sinensis, 2-30 parts of mulberry leaves, 2-40 parts of pine needles, 2-30 parts of glossy privet fruits, 1-30 parts of ligusticum wallichii, 1-40 parts of polygonum multiflorum, 1-40 parts of prepared rehmannia roots, 1-40 parts of gallnut, 1-40 parts of cortex dictamni and 1-40 parts of menthol. The raw materials in the traditional Chinese medicine shampoo supplement each other and act synergistically, so that the traditional Chinese medicine shampoo has the remarkable effects of degreasing, diminishing inflammation, resisting bacteria, relieving itching, resisting allergy, cooling blood, activating blood circulation, preventing alopecia, promoting hair growth and nourishing hair, has remarkable curative effects on improving symptoms of hair oil and itching, reducing alopecia and promoting the growth of new hair, and has a good treatment effect on seborrheic alopecia.

Description

Traditional Chinese medicine shampoo for treating seborrheic alopecia and application thereof
Technical Field
The invention belongs to the technical field of daily chemical products, and particularly relates to traditional Chinese medicine shampoo for treating seborrheic alopecia and application thereof.
Background
At present, seborrheic alopecia is the most common one of alopecia types, and is also called androgenetic alopecia. Seborrheic alopecia is characterized by water-oil imbalance, oily scalp due to excessive fat overflow at scalp part, scalp itching and inflammation, seborrheic dermatitis caused by infection due to excessive oil and dampness of scalp, bacterial reproduction acceleration, oily and shiny hair loss area in severe cases, and thin, soft and yellow residual hair. Seborrheic alopecia can be divided into acute seborrheic alopecia and chronic seborrheic alopecia, wherein the hair of the former falls off in a short time and even completely falls off, and is easy to relapse after being cured; the latter hair is slowly shed, exposing the scalp, but is less likely to form baldness.
Seborrheic alopecia occurs mainly in young men, few women and many brainworkers, but in recent years, the number of female patients is increased. Clinically, it is preliminarily verified that seborrheic alopecia may be related to heredity, male hormone, mental state, scalp fat overflow condition and some pharmaceutical factors, and the seborrheic alopecia is caused by the combined action of multiple factors, while the existing shampoo products for treating seborrheic alopecia only focus on single-aspect efficacy or have the problem of unscientific formula, so that the treatment effect is limited, symptoms are usually treated but not the root, and a considerable part of patients suffering from seborrheic alopecia cannot be effectively treated.
Disclosure of Invention
According to one aspect of the invention, the traditional Chinese medicine shampoo for treating seborrheic alopecia is provided, and the active ingredients of the traditional Chinese medicine shampoo comprise the following raw materials in parts by mass: 20-100 parts of tea seed cake, 10-100 parts of cacumen biotae, 20-80 parts of chrysanthemum morifolium, 20-80 parts of cynanchum paniculatum, 20-80 parts of honeysuckle, 2-40 parts of liquorice, 2-30 parts of angelica sinensis, 2-30 parts of mulberry leaves, 2-40 parts of pine needles, 2-30 parts of glossy privet fruits, 1-30 parts of ligusticum wallichii, 1-40 parts of polygonum multiflorum, 1-40 parts of prepared rehmannia roots, 1-40 parts of gallnut, 1-40 parts of cortex dictamni and 1-40 parts of menthol.
The invention considers that the pathogenesis of the seborrheic alopecia is mainly blood-heat wind dryness at the initial stage, blood deficiency wind dryness is caused by heat damaging yin and blood after a long-term disease, and simultaneously, the disease can be caused by dampness-heat of spleen and stomach: on one hand, food stagnation and damp evil accumulation, stagnated heat transforming into fire, steaming on the head and face, dampness obstructing the meridians and hair malnutrition; on the other hand, spleen-stomach disharmony, spleen dysfunction, transformation, passivity and hair malnutrition. The long course of disease can damage liver and kidney, resulting in deficiency of liver-yin and kidney-yin, and deficiency of spleen-kidney yang.
The invention is designed according to the etiology and pathogenesis of seborrheic alopecia, and specifically comprises the following steps:
chuan Xiong-Dang Gui is combined to activate qi and blood, guide the herbs to move upward to head and eyes, and can treat alopecia caused by liver depression, qi stagnation, unsmooth circulation of qi and blood and failure to nourish hair.
The liquorice and the angelica are compatible, the angelica is a main drug for harmonizing blood and enriching blood, and the liquorice has the effects of tonifying spleen and qi, has mild effect and can enhance the effects of enriching blood and nourishing hair of the angelica.
The arborvitae tops and the menthol are compatible, have cold and cool properties, have the effects of clearing heat, eliminating dampness and reducing fat, can effectively eliminate the damp-heat state in the body and improve the seborrheic alopecia caused by the damp-heat in the body.
The compatibility of fleece-flower root and Chinese angelica root, fleece-flower root is good at nourishing liver and kidney and benefiting essence and blood, Chinese angelica root is good at enriching blood, and the two are used together to nourish essence and blood and nourish hair, so as to make hair grow actively.
The chrysanthemum morifolium ramat-paniculate swallowwort root is compatible with the chrysanthemum morifolium ramat-paniculatum, and can dispel wind, eliminate dampness, relieve itching, refresh body and relieve skin pruritus symptoms.
The pharmacological actions of the traditional Chinese medicine components of the invention are as follows:
tea seed cake: the tea seed cake is residue left after oil extraction of tea-oil tree fruits, contains 12-17% of tea saponin, protein, natural tea oil, amino acid, fine fiber and other components, is an excellent nonionic natural surfactant, has good nursing effect on scalp and hair, can supplement nutrients and trace elements required by hair, enhance scalp blood vessel microcirculation, has the effects of washing hair, protecting hair, removing dandruff, preventing alopecia and the like, can stop dandruff, relieve itching, remove oil, sterilize and repair damaged hair after long-term use, and also has obvious hair blackening and growing effects.
Cacumen biotae: dried shoot tips and leaves of Franco of the family Cupressaceae, Platylladus orientalis (L.). Is cold in nature and bitter in taste, and has effects of cooling blood, stopping bleeding, blackening beard and hair, and preventing alopecia.
Hangzhou chrysanthemum: is slightly cold in nature, contains inulin, glance sideways at N, amino acids and trace vitamins, and has antibacterial, antiinflammatory and antioxidant effects.
Paniculate swallowwort root: dried root and rhizome of Cynanchum paniculatum Cynanchum Panenchum paniculatum (Bge.) of genus Cynanchum of family Asclepiadaceae. Has warm nature, pungent and cool taste, no toxicity, and can dispel wind and dampness, relieve pain and itching.
Honeysuckle flower: dried flower buds or flowers with bloomes of Lonicera japonica Thunb, Lonicera hypoglauca Miq, Lonicera confusa DC, or Lonicera dasystyla Rehd, Lonicera dasystyla of Caprifoliaceae. Cold in nature, fragrant in smell, light and slightly bitter in taste, can clear both qi and blood heat, and has the functions of tonifying deficiency, nourishing blood, entering lung to dissipate heat, clearing away heat and toxic material, diminishing inflammation, relieving swelling, sterilizing and inhibiting bacteria.
Licorice root: dried root of Glycyrrhiza uralensis Fisch, Glycyrrhiza inflata Bat, or Glycyrrhiza glabra L, which are leguminous plants. Has light smell, mild property and sweet taste, has the functions of clearing away heat and toxic material, invigorating spleen and replenishing qi, and can regulate medicine property, alleviate medicine intensity, toxicity and the like.
Chinese angelica: dried roots of Angelica sinensis (Oliv.) Diels of Umbelliferae. Has warm nature and sweet taste, and has the effects of diminishing inflammation, relieving pain, inhibiting bacteria, enriching blood and promoting blood circulation.
Mulberry leaf: dried leaves of Morus alba L. of Moraceae. Cold in nature and sweet and bitter in taste. Disperse wind-heat, clear liver heat to improve vision, cool blood to stop bleeding.
Pine needle: leaf of Pinus tabulaeformis, Pinus massoniana, Pinus yunnanensis, etc. Warm in nature, bitter and astringent in taste, and has effects of dispelling pathogenic wind, promoting blood circulation, removing toxic substance, resisting bacteria, and relieving itching.
Glossy privet fruit: dried ripe fruit of Ligustrum lucidum Lucidudoit. Has cool nature and sweet taste, and has effects of nourishing liver and kidney, improving eyesight and blackening hair.
Ligusticum wallichii: dried rhizome of Ligusticum chuanxiong Hort (or Ligusticum wallichii Franch.) belonging to Umbelliferae. Warm in nature, pungent in flavor, promoting blood circulation to remove blood stasis, dispelling wind and relieving pain.
Polygonum multiflorum: dried root tuber of Polygonum multiflorum Thunb of Polygonaceae. Warm in nature, sweet in taste and non-toxic. Tonify liver and kidney, nourish blood and dispel wind.
Prepared rehmannia root: root tuber of rehmannia Rehm, Annia glutinosa Libosch. Sweet in flavor and slightly warm in nature. To nourish yin, enrich blood, replenish essence and replenish marrow.
Gallnut: gallnut is mainly parasitized by gallnut aphid melaphilis (Bell) Baker on leaves of Rhus chinensis Mill, Rhus potaninii Maxim, Rhus cornutus or Rhus cornutus pun-jabensis Stew. Has mild property, bitter and sour taste and no toxicity, and has the effects of astringing lung, reducing pathogenic fire, astringing dampness and healing sore.
And (3) preparing cortex dictamni: dried root bark of Dictamnus dasycarpus Turcz. Slightly bitter and cold in nature, and has the effects of clearing heat, eliminating dampness, dispelling wind and removing toxicity.
Menthol: the crystal extracted from Mentha haplocalyx Briq. of Mentha of Labiatae is colorless or white needle-like or prism-like crystal, has cold nature and special odor of herba Menthae, and has effects of clearing away heat and toxic materials and dispelling pathogenic wind.
In some embodiments, the active ingredients thereof consist of the following raw materials in parts by mass: 76 parts of tea seed cake, 40 parts of cacumen biotae, 33 parts of chrysanthemum morifolium, 33 parts of cynanchum paniculatum, 30 parts of honeysuckle, 10 parts of liquorice, 10 parts of angelica sinensis, 10 parts of mulberry leaves, 10 parts of pine needles, 10 parts of glossy privet fruits, 8 parts of ligusticum wallichii, 8 parts of polygonum multiflorum, 8 parts of prepared rehmannia roots, 8 parts of gallnut, 8 parts of cortex dictamni and 5 parts of menthol.
In some embodiments, a cosmetically or pharmaceutically acceptable excipient is also included. Therefore, the stability of the product can be improved, the curative effect of the product can be improved to a certain extent, and the product can be endowed with better use feeling.
In some embodiments, the cosmetically or pharmaceutically acceptable excipient is one or more of a surfactant, a hair conditioner, a pH adjuster, a dispersant, a viscosity adjuster, a chelating agent, a preservative, a colorant, a pearlescent agent, and a fragrance, and the water is one or more of purified water, distilled water, and deionized water. Preferably, the cosmetically or pharmaceutically acceptable carrier comprises ethylparaben, coconut oil fatty acid diethanolamide (6501), sodium fatty Alcohol Ether Sulfate (AES) and sodium chloride, and the efficacy of each additive is as follows:
ethyl paraben: is white crystal of formula C9H10O3Can be used as antiseptic and bacteriostatic agent.
Coconut oil fatty acid diethanolamide: the product name is 6501, CDEA, belongs to nonionic surfactant, has good effects of foaming, foam stabilization, penetration decontamination, hard water resistance and the like, and has low toxicity and small irritation to eyes and skin.
Sodium fatty alcohol polyoxyethylene ether sulfate: AES belongs to an anionic surfactant, has excellent decontamination and emulsification properties, has wetting, solubilizing and thickening effects, can be compatible with various matrixes, has strong hard water resistance, high biodegradation degree and small irritation to skin and eyes. The product has rich and fine foam, can soften hair, is easy to comb, can make skin smooth, and can increase the comfort of the product after use.
Sodium chloride: regulating viscosity, increasing viscosity, improving apparent consistency, and moistening hair core.
In some embodiments, the traditional Chinese medicine shampoo for treating seborrheic alopecia consists of the following raw materials in parts by mass: 20-100 parts of tea seed cake, 10-100 parts of cacumen biotae, 20-80 parts of chrysanthemum morifolium, 20-80 parts of cynanchum paniculatum, 20-80 parts of honeysuckle, 2-40 parts of liquorice, 2-30 parts of angelica sinensis, 2-30 parts of mulberry leaves, 2-40 parts of pine needles, 2-30 parts of glossy privet fruits, 1-30 parts of ligusticum wallichii, 1-40 parts of polygonum multiflorum, 1-40 parts of prepared rehmannia roots, 1-40 parts of gallnut, 1-40 parts of cortex dictamni, 1-40 parts of menthol, 1-2 parts of ethylparaben, 80-85 parts of coconut oil fatty acid diethanolamide, 55-60 parts of fatty alcohol-polyoxyethylene ether sodium sulfate and 17-21 parts of sodium chloride.
According to another aspect of the invention, the application of the traditional Chinese medicine shampoo in preparing products for treating seborrheic alopecia, alopecia areata, postpartum alopecia and hereditary alopecia is provided.
The raw materials in the traditional Chinese medicine shampoo supplement each other and act synergistically, so that the traditional Chinese medicine shampoo has the remarkable effects of degreasing, diminishing inflammation, resisting bacteria, relieving itching, resisting allergy, cooling blood, activating blood circulation, preventing alopecia, promoting hair growth and nourishing hair, has remarkable curative effects on improving symptoms of hair oil and itching, reducing alopecia and promoting the growth of new hair, and has a good treatment effect on seborrheic alopecia.
Detailed Description
The present invention will be described in further detail with reference to specific examples.
Example 1
The traditional Chinese medicine shampoo for treating seborrheic alopecia comprises the following raw materials in parts by mass: 76g of tea seed cake, 40g of cacumen biotae, 33g of chrysanthemum morifolium, 33g of paniculate swallowwort root, 30g of honeysuckle, 10g of liquorice, 10g of angelica, 10g of mulberry leaf, 10g of pine needle, 10g of glossy privet fruit, 8g of ligusticum wallichii, 8g of polygonum multiflorum, 8g of prepared rehmannia root, 8g of gallnut, 8g of cortex dictamni, 5g of menthol, 1g of ethylparaben, 83g of coconut oil fatty acid diethanolamide (6501), 58g of sodium fatty alcohol polyoxyethylene ether sulfate (AES) and 19g of sodium chloride.
The preparation method comprises the following steps:
(1) preparing a traditional Chinese medicine extracting solution: weighing the traditional Chinese medicine components according to the raw material ratio, mixing, placing in a liquid heating extraction tank, adding purified water, soaking the medicine powder, decocting for three times (the extraction time is 1h, 45min and 45min after the medicine liquid is boiled respectively), combining the three filtrates, filtering with gauze, concentrating to 200mL, and cooling to room temperature;
(2) alcohol precipitation: adding appropriate amount of ethanol until the ethanol content reaches 70%, standing for 24 hr, filtering, and recovering ethanol;
(3) adding ethylparaben into the obtained liquid medicine, boiling for dissolving, then adding purified water to 500mL (the relative density of the liquid medicine is not lower than 1.013), heating the liquid medicine to 90 ℃, adding 6501, AES and sodium chloride, continuously stirring for complete dissolution, cooling to room temperature, adding menthol dissolved in 15mL of 95% ethanol, stirring uniformly, and adding purified water to 1000mL to obtain the finished product.
Example 2
The traditional Chinese medicine shampoo for treating seborrheic alopecia comprises the following raw materials in parts by mass: 152g of tea seed cake, 80g of cacumen biotae, 66g of chrysanthemum morifolium, 66g of paniculate swallowwort root, 60g of honeysuckle, 20g of liquorice, 20g of angelica, 20g of mulberry leaf, 20g of pine needle, 20g of glossy privet fruit, 16g of ligusticum wallichii, 16g of polygonum multiflorum, 16g of prepared rehmannia root, 16g of gallnut, 16g of cortex dictamni, 10g of menthol, 1g of ethylparaben, 83g of coconut oil fatty acid diethanolamide (6501), 58g of sodium fatty alcohol polyoxyethylene ether sulfate (AES) and 19g of sodium chloride.
The preparation method comprises the following steps:
(1) preparing a traditional Chinese medicine extracting solution: weighing the traditional Chinese medicine components according to the raw material ratio, mixing, placing in a liquid heating extraction tank, adding purified water, soaking the medicine powder, decocting for three times (the extraction time is 1h, 45min and 45min after the medicine liquid is boiled respectively), combining the three filtrates, filtering with gauze, concentrating to 200mL, and cooling to room temperature;
(2) alcohol precipitation: adding appropriate amount of ethanol until the ethanol content reaches 70%, standing for 24 hr, filtering, and recovering ethanol;
(3) adding ethylparaben into the obtained liquid medicine, boiling for dissolving, then adding purified water to 500mL (the relative density of the liquid medicine is not lower than 1.013), heating the liquid medicine to 90 ℃, adding 6501, AES and sodium chloride, continuously stirring for complete dissolution, cooling to room temperature, adding menthol dissolved in 15mL of 95% ethanol, stirring uniformly, and adding purified water to 1000mL to obtain the finished product.
Example 3
The traditional Chinese medicine shampoo for treating seborrheic alopecia comprises the following raw materials in parts by mass: 38g of tea seed cake, 20g of cacumen biotae, 16.5g of chrysanthemum morifolium, 16.5g of cynanchum paniculatum, 15g of honeysuckle, 5g of liquorice, 5g of angelica sinensis, 5g of mulberry leaves, 5g of pine needles, 5g of glossy privet fruits, 4g of ligusticum wallichii, 4g of polygonum multiflorum, 4g of prepared rehmannia roots, 4g of gallnuts, 4g of cortex dictamni, 2.5g of menthol, 1g of ethylparaben, 83g of coconut oil fatty acid diethanolamide (6501), 58g of sodium fatty alcohol polyoxyethylene ether sulfate (AES) and 19g of sodium chloride.
The preparation method comprises the following steps:
(1) preparing a traditional Chinese medicine extracting solution: weighing the traditional Chinese medicine components according to the raw material ratio, mixing, placing in a liquid heating extraction tank, adding purified water, soaking the medicine powder, decocting for three times (the extraction time is 1h, 45min and 45min after the medicine liquid is boiled respectively), combining the three filtrates, filtering with gauze, concentrating to 200mL, and cooling to room temperature;
(2) alcohol precipitation: adding appropriate amount of ethanol until the ethanol content reaches 70%, standing for 24 hr, filtering, and recovering ethanol;
(3) adding ethylparaben into the obtained liquid medicine, boiling for dissolving, then adding purified water to 500mL (the relative density of the liquid medicine is not lower than 1.013), heating the liquid medicine to 90 ℃, adding 6501, AES and sodium chloride, continuously stirring for complete dissolution, cooling to room temperature, adding menthol dissolved in 15mL of 95% ethanol, stirring uniformly, and adding purified water to 1000mL to obtain the finished product.
Comparative example 1
The traditional Chinese medicine shampoo without tea seed cake and chrysanthemum morifolium ramat is composed of the following raw materials in parts by mass: 40g of cacumen biotae, 33g of paniculate swallowwort root, 30g of honeysuckle, 10g of liquorice, 10g of angelica, 10g of mulberry leaf, 10g of pine needle, 10g of glossy privet fruit, 8g of ligusticum wallichii, 8g of polygonum multiflorum, 8g of prepared rehmannia root, 8g of gallnut, 8g of cortex dictamni, 5g of menthol, 1g of ethylparaben, 83g of coconut oil fatty acid diethanolamide (6501), 58g of sodium fatty alcohol polyoxyethylene ether sulfate (AES) and 19g of sodium chloride.
The preparation method comprises the following steps:
(1) preparing a traditional Chinese medicine extracting solution: weighing the traditional Chinese medicine components according to the raw material ratio, mixing, placing in a liquid heating extraction tank, adding purified water, soaking the medicine powder, decocting for three times (the extraction time is 1h, 45min and 45min after the medicine liquid is boiled respectively), combining the three filtrates, filtering with gauze, concentrating to 200mL, and cooling to room temperature;
(2) alcohol precipitation: adding appropriate amount of ethanol until the ethanol content reaches 70%, standing for 24 hr, filtering, and recovering ethanol;
(3) adding ethylparaben into the obtained liquid medicine, boiling for dissolving, then adding purified water to 500mL (the relative density of the liquid medicine is not lower than 1.013), heating the liquid medicine to 90 ℃, adding 6501, AES and sodium chloride, continuously stirring for complete dissolution, cooling to room temperature, adding menthol dissolved in 15mL of 95% ethanol, stirring uniformly, and adding purified water to 1000mL to obtain the finished product.
Next, in order to investigate the treatment effect of the traditional Chinese medicine shampoo of the present invention on seborrheic alopecia, clinical trials were performed on the traditional Chinese medicine shampoo prepared in example 1.
1. Test object
60 patients with seborrheic alopecia are randomly selected, the patients are 20-50 years old, the patients are randomly divided into a control group, a treatment group, a tea meal lacking group and a chrysanthemum morifolium group, the age, the disease course and the alopecia degree of each group of the patients are basically consistent, no obvious difference exists, and the patients have comparability.
2. Method of treatment
Treatment groups: after the hair of a patient is washed clean by warm clear water, 5-20 mL of the traditional Chinese medicine shampoo in the embodiment 1 is smeared on wet hair, gently massaged for 3 minutes, and then washed by warm water for 1-2 times per day.
Lack of tea seed cake and chrysanthemum morifolium group: after the hair of a patient is washed clean by warm clear water, 5-20 mL of the traditional Chinese medicine shampoo in comparative example 1 is smeared on wet hair, gently massaged for 3 minutes, and then washed by warm water for 1-2 times per day.
Control group: after the hair of a patient is washed clean by warm clear water, 5-20 mL of ketoconazole lotion (the ketoconazole lotion is a common product for treating seborrheic alopecia at present and can be purchased on the market) is applied to wet hair, gently massaged for 3 minutes, and then washed by warm water for 1-2 times per day.
Three groups of patients did not use any other cosmetics, drugs and nutraceuticals that had an effect on the outcome during the trial period, and were able to maintain the regularity of normal life during the trial period. Follow-up was performed on day 0, day 10, day 30 and day 60, respectively, and the side reactions of the shed hair and scalp were observed and questionnaires were performed for each subject, and the results were recorded.
3. Standard of therapeutic effect
And (3) healing: the hair stops falling off, the alopecia symptoms are obviously improved, the hair quality is thickened, fine hair grows at more than 90 percent of the alopecia positions, the growth density is normal, no greasy feeling exists, no pruritus exists, and no dandruff appears.
The effect is shown: the hair stops falling off, the alopecia symptoms are obviously improved, the hair quality is thickened, fine hair grows at 60-90% of the alopecia positions, the greasy feeling and the dandruff are obviously reduced, and the pruritus is obviously relieved.
The method has the following advantages: the hair loss is obviously reduced, the hair loss symptom is primarily improved, the hair quality is thickened, in addition, fine hair grows at 30-60% of hair loss positions, the greasy feeling and the dandruff are reduced, and the pruritus is relieved.
And (4) invalidation: the hair is continuously dropped, the alopecia symptoms are not improved, the hair quality is not changed or is not obviously changed, fine hair is not grown or is grown at less than 30 percent of the alopecia positions, the feeling of greasiness, pruritus and scurf are not relieved.
4. Therapeutic results
The results of the three groups of treatments after 2 months of treatment are shown in table 1:
TABLE 1 treatment results for three groups of patients with seborrheic alopecia
Recovery method Show effect Is effective Invalidation Cure rate High efficiency
Control group 12 3 2 3 60% 85%
Treatment group 15 2 1 2 75% 90%
Lack tea seed cake and chrysanthemum morifolium group 10 3 2 5 50% 75%
As can be seen from Table 1, the cure rate of the treatment group is 75%, and the effective rate is 90%; the cure rate of the control group is 60 percent, and the effective rate is 85 percent; the cure rate of the tea-lack and chrysanthemum morifolium group is 50%, and the effective rate is 75%. The cure rate and the effective rate of the treatment group are obviously higher than those of the control group, the tea cake-lacking group and the chrysanthemum morifolium group.
Therefore, the raw materials in the traditional Chinese medicine shampoo supplement each other and perform a synergistic effect, so that the traditional Chinese medicine shampoo has the remarkable effects of removing fat, diminishing inflammation, resisting bacteria, relieving itching, resisting allergy, cooling blood, activating blood, preventing alopecia, promoting hair growth and nourishing hair, has remarkable curative effects on improving symptoms of hair oil and itching, reducing alopecia and promoting the growth of new hair, and has a good treatment effect on seborrheic alopecia.
The traditional Chinese medicine shampoo disclosed by the invention is used for treating seborrheic alopecia and has a certain treatment effect on alopecia areata, postpartum alopecia and hereditary alopecia.

Claims (7)

1. The traditional Chinese medicine shampoo for treating seborrheic alopecia is characterized in that active ingredients of the shampoo comprise the following raw materials in parts by mass: 20-100 parts of tea seed cake, 10-100 parts of cacumen biotae, 20-80 parts of chrysanthemum morifolium, 20-80 parts of cynanchum paniculatum, 20-80 parts of honeysuckle, 2-40 parts of liquorice, 2-30 parts of angelica sinensis, 2-30 parts of mulberry leaves, 2-40 parts of pine needles, 2-30 parts of glossy privet fruits, 1-30 parts of ligusticum wallichii, 1-40 parts of polygonum multiflorum, 1-40 parts of prepared rehmannia roots, 1-40 parts of gallnut, 1-40 parts of cortex dictamni and 1-40 parts of menthol.
2. The traditional Chinese medicine shampoo for treating seborrheic alopecia according to claim 1, which is characterized in that active ingredients comprise the following raw materials in parts by mass: 76 parts of tea seed cake, 40 parts of cacumen biotae, 33 parts of chrysanthemum morifolium, 33 parts of cynanchum paniculatum, 30 parts of honeysuckle, 10 parts of liquorice, 10 parts of angelica sinensis, 10 parts of mulberry leaves, 10 parts of pine needles, 10 parts of glossy privet fruits, 8 parts of ligusticum wallichii, 8 parts of polygonum multiflorum, 8 parts of prepared rehmannia roots, 8 parts of gallnut, 8 parts of cortex dictamni and 5 parts of menthol.
3. The traditional Chinese medicine shampoo for treating seborrheic alopecia according to claim 1 or 2, which is characterized by further comprising cosmetically or pharmaceutically acceptable auxiliary materials.
4. The traditional Chinese medicine shampoo for treating seborrheic alopecia according to claim 3, wherein the cosmetically or pharmaceutically acceptable carrier is one or more of a surfactant, a hair conditioner, a pH regulator, a dispersant, a viscosity regulator, a chelating agent, a preservative, a coloring agent, a pearling agent and an essence, and the water is one or more of purified water, distilled water and deionized water.
5. The traditional Chinese medicine shampoo for treating seborrheic alopecia according to claim 4, wherein the cosmetically or pharmaceutically acceptable carrier comprises ethylparaben, coconut diethanolamide, sodium fatty alcohol polyoxyethylene ether sulfate and sodium chloride.
6. The traditional Chinese medicine shampoo for treating seborrheic alopecia according to claim 5, which is characterized by comprising the following raw materials in parts by mass: 20-100 parts of tea seed cake, 10-100 parts of cacumen biotae, 20-80 parts of chrysanthemum morifolium, 20-80 parts of cynanchum paniculatum, 20-80 parts of honeysuckle, 2-40 parts of liquorice, 2-30 parts of angelica sinensis, 2-30 parts of mulberry leaves, 2-40 parts of pine needles, 2-30 parts of glossy privet fruits, 1-30 parts of ligusticum wallichii, 1-40 parts of polygonum multiflorum, 1-40 parts of prepared rehmannia roots, 1-40 parts of gallnut, 1-40 parts of cortex dictamni, 1-40 parts of menthol, 1-2 parts of ethylparaben, 80-85 parts of coconut oil fatty acid diethanolamide, 55-60 parts of fatty alcohol-polyoxyethylene ether sodium sulfate and 17-21 parts of sodium chloride.
7. Use of the traditional Chinese medicine shampoo as defined in any one of claims 1 to 6 in the preparation of products for treating seborrheic alopecia, alopecia areata, postpartum alopecia and hereditary alopecia.
CN202110265621.2A 2021-03-11 2021-03-11 Traditional Chinese medicine shampoo for treating seborrheic alopecia and application thereof Pending CN112773748A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202110265621.2A CN112773748A (en) 2021-03-11 2021-03-11 Traditional Chinese medicine shampoo for treating seborrheic alopecia and application thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202110265621.2A CN112773748A (en) 2021-03-11 2021-03-11 Traditional Chinese medicine shampoo for treating seborrheic alopecia and application thereof

Publications (1)

Publication Number Publication Date
CN112773748A true CN112773748A (en) 2021-05-11

Family

ID=75762549

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202110265621.2A Pending CN112773748A (en) 2021-03-11 2021-03-11 Traditional Chinese medicine shampoo for treating seborrheic alopecia and application thereof

Country Status (1)

Country Link
CN (1) CN112773748A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113509420A (en) * 2021-08-10 2021-10-19 郑州润奇科技有限公司 Process for treating seborrheic alopecia by KPT (KPT-based natural immunotherapy)
CN113599472A (en) * 2021-08-13 2021-11-05 北京良方科技有限公司 Traditional Chinese medicine preparation for treating seborrheic alopecia and preparation method and application thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104095780A (en) * 2013-04-09 2014-10-15 廖少波 Hair-blacking and hair loss-preventing plant shampoo and preparation method thereof
CN108743729A (en) * 2018-06-14 2018-11-06 广州植境生物科技有限公司 A kind of herb composition that treating alopecia seborrheica and nanometer hair nourishing liquid
CN110279775A (en) * 2019-07-09 2019-09-27 上海中医大生物科技有限公司 A kind of Chinese medicine composition of phalacrosis prevention and hair generation and preparation method thereof
CN110917325A (en) * 2019-11-29 2020-03-27 杜立波 Pure plant hair-blacking hair-growing anti-alopecia liquid and preparation method thereof
CN112402541A (en) * 2020-12-20 2021-02-26 胡立纯 Composition for improving hair quality and preparation method and application thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104095780A (en) * 2013-04-09 2014-10-15 廖少波 Hair-blacking and hair loss-preventing plant shampoo and preparation method thereof
CN108743729A (en) * 2018-06-14 2018-11-06 广州植境生物科技有限公司 A kind of herb composition that treating alopecia seborrheica and nanometer hair nourishing liquid
CN110279775A (en) * 2019-07-09 2019-09-27 上海中医大生物科技有限公司 A kind of Chinese medicine composition of phalacrosis prevention and hair generation and preparation method thereof
CN110917325A (en) * 2019-11-29 2020-03-27 杜立波 Pure plant hair-blacking hair-growing anti-alopecia liquid and preparation method thereof
CN112402541A (en) * 2020-12-20 2021-02-26 胡立纯 Composition for improving hair quality and preparation method and application thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
刘维: "陈达灿教授论治脂溢性脱发经验撷萃", 《中医药学刊》 *
王衍生等: "《中草药学》", 31 August 1982, 浙江科学技术出版社 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113509420A (en) * 2021-08-10 2021-10-19 郑州润奇科技有限公司 Process for treating seborrheic alopecia by KPT (KPT-based natural immunotherapy)
CN113599472A (en) * 2021-08-13 2021-11-05 北京良方科技有限公司 Traditional Chinese medicine preparation for treating seborrheic alopecia and preparation method and application thereof

Similar Documents

Publication Publication Date Title
CN105997836B (en) A kind of ferment shampoo and its preparation method
KR101478945B1 (en) Shampoo composition containing native plant extracts and natural oriental material extracts
KR100893106B1 (en) Composition for promoting hair growth
CN104042528A (en) Herbal hair-nourishing hair-loss-preventing dandruff-removing stock shampoo and preparation method thereof
CN104382786A (en) Hair loss prevention hair-blacking agent and preparation method thereof
KR101263181B1 (en) The scalp care composition for preventing depilation and improvement of hair growth and the shampoo using the composition
CN105078850A (en) Liquid shampoo and preparation method thereof
CN108096091B (en) Composition containing Cordyceps extract for preventing alopecia, promoting hair growth and blackening hair, and its preparation method
KR20220052311A (en) Korean traditional herbs shampoo composition and manufacturing method thereof
KR20170050222A (en) The manufacturing method of shampoo composition for caring scalp and promoting hair growth, and shampoo composition thereof
KR101128564B1 (en) The manufacturing process of lithospermum erythrorhizon soap controlled by vineger
CN110279775A (en) A kind of Chinese medicine composition of phalacrosis prevention and hair generation and preparation method thereof
CN111529477A (en) Composition for caring hair, and preparation and application thereof
CN112870333A (en) Composition and preparation for improving alopecia and promoting hair growth of human, and preparation method and application thereof
CN112773748A (en) Traditional Chinese medicine shampoo for treating seborrheic alopecia and application thereof
KR100931093B1 (en) Composition for reinforcement of hair-roots and cleanness of scalp and its preparation method
CN114533624A (en) White hair blackening liquid and preparation method thereof
KR20090002854A (en) Composition for stimulating/inducing hair growth andprocess for their preparation
KR20080080792A (en) Growing hair-functional soap for medical herb extracts and its manufacturing method
CN102670479B (en) Traditional Chinese medicine antiphlogistic acne-pullout cosmetic cream and preparation method thereof
KR102030275B1 (en) Hair cleanser composition
CN110693786A (en) Traditional Chinese medicine hair care agent and preparation method thereof
CN106177192B (en) Bi-component compound medicine for treating head oil and dandruff and preparation method thereof
CN105168041A (en) Anti-dandruff antipruritic shampoo and preparation method thereof
CN115227801A (en) Hair loss preventing and blackening hair growth liquid, shampoo containing hair loss preventing and blackening hair growth liquid and application of hair loss preventing and blackening hair growth liquid

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20210511

RJ01 Rejection of invention patent application after publication