CN103169800A - Traditional Chinese medicine composition for treating acne and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for treating acne and preparation method and application thereof Download PDFInfo
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- CN103169800A CN103169800A CN 201110434583 CN201110434583A CN103169800A CN 103169800 A CN103169800 A CN 103169800A CN 201110434583 CN201110434583 CN 201110434583 CN 201110434583 A CN201110434583 A CN 201110434583A CN 103169800 A CN103169800 A CN 103169800A
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Abstract
The invention relates to the technical field of a medicine, and provides a traditional Chinese medicine composition containing golden cypress for treating acne and a preparation method of the traditional Chinese medicine composition, and application of the traditional Chinese medicine composition in preparation of a drug for treating the acne. The composition disclosed by the invention is better in curative effect of treating the acne, and smaller in side effect.
Description
Invention field
The invention belongs to medical technological invention field, be specifically related to a kind of Chinese medicine composition that is used for the treatment of acne, its preparation method with and application in the preparation Retinoids, Retin-A, Renova, Accutane, this Chinese medicine composition contains Cortex Phellodendri.
Background technology
Acne is commonly called as " comedo ", is again " pimples ", " acne ", " whelk " or " skin sore " etc., is due to hair follicle and sebaceous gland obstruction, a kind of chronic inflammatory disease dermatoses that inflammation causes.It is also one of modal sick kind of Skin cosmesis.Usually be apt to occur in face, cervical region, chest and back, shoulder and upper arm.Clinical take hoary hair's acne, blackhead, inflammatory pimple, pustule, tuberosity, cyst etc. as main manifestations.This disease adolescence is common, but also not exclusively is subjected to the restriction of age level, and from child to adult, the people of nearly all age bracket can fall ill.Take erythema, pimple, blister, erosion, leaching, pruritus with outbreak is as main feature repeatedly, skin lesion has the multirow infringement, affects attractive in appearance.The patient is hard to bear pruritus and pain not only, also will stand the impaired mental anguish of skin contours that brings thus.
On existing market, the chemical drugs of Acne treatment is mainly used antibiotic, and take anti-inflammation as main, but some medicine contains tetracycline.If long-term taking can increase the weight of the burden of liver, kidney virtually, the anemia of pregnant woman especially there is taboo.Medicine dedicated commonly used is adapalene and compound recipe acetic acid cyclopropanone sheet etc. at present, but these medical instruments have very large side effect, may bring out other skin diseases.
And China's Traditional Chinese Medicine has accumulated very rich experience aspect acne treatment, the traditional Chinese medical science think acne morbidity and damp and hot cause endogenous toxin accumulate long-pending due to, and it is at poison, it is shown in heat.Therefore often with damp eliminating evanescence of heat endogenous toxin method giving consideration to both the incidental and fundamental, both passed through dehumidifying medicine of a warm nature material toxin expelling, to reach the purpose of eliminating acne in clinical practice.The inventor finds in a long-term line clinical position, employing has the Cortex Phellodendri of toxin expelling dehumidifying, the Fructus Gardeniae of clearing away heat-damp and promoting diuresis is made up, be equipped with again the Fructus Tribuli with expelling wind and removing dampness effect, play altogether the effect except the damp and hot endogenous toxin of dispelling, have good efficacy aspect Acne treatment, simultaneously the present composition adopts is cheap nontoxic pure Chinese crude drug, not only safe and effective, and be easy to industrialization production, after can obtain better economic well-being of workers and staff and social benefit.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine composition of Acne treatment.
The invention provides a kind of Chinese medicine composition of Acne treatment, this Chinese medicine composition is prepared from by the raw material of following weight proportioning: 30～90 parts of 10～60 parts of Cortex Phellodendris, 20～70 parts of Fructus Gardeniaes and Fructus Tribulis.
In order to reach better therapeutic effect, preferred, Chinese medicine composition of the present invention is prepared from by the raw material of following weight proportioning: 45～60 parts of 20～40 parts of Cortex Phellodendris, 35～50 parts of Fructus Gardeniaes and Fructus Tribulis.
In order to make therapeutic effect reach best, preferred, Chinese medicine composition of the present invention is prepared from by the raw material of following weight proportioning: 50 parts of 30 parts of Cortex Phellodendris, 40 parts of Fructus Gardeniaes and Fructus Tribulis.
Another object of the present invention aims to provide a kind of method for preparing Retinoids, Retin-A, Renova, Accutane, and the preparation method of this Chinese medicine composition of Acne treatment involved in the present invention is as follows:
A, take Cortex Phellodendri, Fructus Gardeniae and Fructus Tribuli by proportioning;
B, Cortex Phellodendri is added 3～12 times of water gagings or alcohol reflux 1～3 time, extracted 2～4 hours at every turn, get filtrate, reclaim ethanol, concentrated solution is standby;
C, Fructus Gardeniae, the Fructus Tribuli two flavor medicated powder of getting counterweight are broken adds 5～10 times of water or ethanol and decocts 2～5 times, and each 1～4 hour, merging filtrate, filtrate is concentrated, is added to after filtrate recycling ethanol again and gets medicinal liquid in the Cortex Phellodendri concentrated solution;
D, C is gone on foot the gained medicinal liquid add the oral liquid adjuvant to make oral liquid; Perhaps C is gone on foot the gained medicinal liquid concentrated after, carry out vacuum drying, get dry extract, then add corresponding pharmaceutic adjuvant mixing, make other oral drug preparation or external preparation.
Described oral drug preparation is tablet, capsule, drop pill, suck any peroral dosage forms such as agent, granule, pill and powder.The active component that is medicine of the present invention can add various conventional adjuvant required when preparing different dosage form, as disintegrating agent, lubricant, binding agent etc., and be prepared into any peroral dosage form commonly used with the method for Chinese medicinal of routine, as pill, powder, tablet, capsule and oral liquid etc.
Described external preparation is any exterior-applied formulations such as liniment, ointment, spray, gel and lotion.The active component that is medicine of the present invention can add various conventional adjuvant required when preparing different dosage form, as lubricant, binding agent etc., and be prepared into any exterior-applied formulation commonly used with the method for Chinese medicinal of routine, as powder, lotion, ointment, spray, gel and ointment etc.
Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional formulation.For example these crude drug pulverize mix homogeneously can be made powder takes after mixing it with water; Also can be with these raw materials decocting together, then the condensed water decocting liquid is made; Can also bring into play better drug effect for each raw material that makes this medicine, preferably the Rhizoma Curcumae Longae in crude drug etc. be carried out special extraction as extracting its volatilization wet goods.But these all can not be used for restriction protection scope of the present invention.
It is in the application of preparation in Retinoids, Retin-A, Renova, Accutane that another object of the present invention aims to provide a kind of pharmaceutical composition that is obtained by above-mentioned preparation method.
Test example one:
In order to verify the present composition in the application of preparation Retinoids, Retin-A, Renova, Accutane, the inventor carries out clinical preliminary test in Changsha 23 Affiliated Hospital of smelting designing institute, and concrete condition is as follows:
One, case is selected
All cases is the adult patients that is diagnosed as acne in outpatient service, and antibiotic or corticosteroid hormone are crossed in not oral or external within 1 week, and agrees to accept this therapy person.Anemia of pregnant woman and serious systemic disease person and can not completing for some reason except this treatment person's course for the treatment of is arranged.
Two, case overview
100 routine patients are selected in this time clinical trial altogether, male patient's 45 examples wherein, female patient's 55 examples.Age is 13～49 years old, and average 23.7 years old, the course of disease was 4 week～5 year, average 1.3 years.
Three, the harmonious check of data
Above-mentioned case is divided into 2 groups at random, i.e. treatment group and matched group.Every group of each 50 examples.Two groups of patients have comparability at aspect no significant differences such as sex, age, the course of disease, stadium and acne distributions.
Four, research method
Comparative study at random.
Five, Therapeutic Method
Treatment group patient gives gel of the present invention (Hunan Jiudian Pharmaceutical Co., Ltd's production), and is each appropriate every day 3 times, affected part of exterior coating, and 1 week was 1 course for the treatment of.The matched group patient gives adapalene gel agent (French high dolantin drugmaker produce), and is each appropriate every day 3 times, affected part of exterior coating, and 1 week was 1 course for the treatment of.During treatment, two groups of patients all do not re-use other any medicines.
Six, result
1, treatment group and matched group Clinical efficacy comparison: through clinical verification, Chinese medicine composition of the present invention has significant curative effect aspect Acne treatment.
Table one, treatment group and matched group Clinical efficacy comparison table
(P＜0.01, difference has very significant)
2, untoward reaction situation
Still find no obvious adverse reaction person in treatment group, in matched group 30 examples rubescent, desquamation appears occurring in various degree significantly or skin uncomfortable.
The specific embodiment
The preparation of embodiment 1, medicine capsule of the present invention
Take respectively Cortex Phellodendri 600g, Fructus Gardeniae 500g and Fructus Tribuli 860g, be prepared into as follows capsule:
A, the Cortex Phellodendri of getting counterweight is added 10 times of water gagings extract 3 times, extracted 1 hour at every turn, filter, merging filtrate, concentrated amalgamation liquid, concentrated solution is standby;
B, Fructus Gardeniae, the Fructus Tribuli two flavor medicated powder of getting counterweight are broken adds 10 times of water 2 times, and each 1.5 hours, merging filtrate was added to after filtrate is concentrated again and gets medicinal liquid in the Cortex Phellodendri concentrated solution;
C, B is gone on foot the gained medicinal liquid carry out vacuum drying, get dry extract, dry extract is added the pharmaceutic adjuvant mixing of suitable capsule, make 1000 seed lac wafers.
The preparation of embodiment 2, drug ointment agent of the present invention
Take respectively Cortex Phellodendri 300g, Fructus Gardeniae 700g and Fructus Tribuli 450g, be prepared into as follows ointment:
A, the Cortex Phellodendri of getting counterweight is added the alcohol reflux 2 times of 5 times of amounts, respectively extracted 3 hours at every turn, get filtrate, concentrated solution is standby;
B, the Fructus Gardeniae of getting counterweight, Fructus Tribuli two flavor medicated powder is broken, the ethanol that adds 15 times decocts 3 times, and each each 1 hour, merging filtrate, filtrate is concentrated, is added in the Cortex Phellodendri concentrated solution to get medicinal liquid after filtrate recycling ethanol again;
C, with B go on foot the gained medicinal liquid concentrated after, carry out vacuum drying, get dry extract, dry extract is added the pharmaceutic adjuvant mixing of suitable ointment, make ointment 100 pipes.
The preparation of embodiment 3, medicine oral liquid of the present invention
Take respectively Cortex Phellodendri 480g, Fructus Gardeniae 500g and Fructus Tribuli 300g, be prepared into as follows oral liquid:
A, the Cortex Phellodendri of getting counterweight is added 5 times of water gagings 5 times, extracted 1 hour at every turn, get filtrate, concentrated solution is standby;
B, Fructus Gardeniae, the Fructus Tribuli two flavor medicated powder of getting counterweight are broken adds 8 times of decoctings and boils 5 times, and each 2 hours, merging filtrate was added to after filtrate is concentrated again and gets medicinal liquid in the Cortex Phellodendri concentrated solution;
C, B is gone on foot the gained medicinal liquid add the oral liquid adjuvant to make 1000 of oral liquids.
The preparation of embodiment 4, medicament gelling agent of the present invention
Take respectively Cortex Phellodendri 150g, Fructus Gardeniae 700g and Fructus Tribuli 900g, be prepared into as follows gel:
A, the Cortex Phellodendri of getting counterweight is added the alcohol reflux 1 time of 8 times of amounts, extracted 4 hours, get filtrate, reclaim ethanol, concentrated solution is standby;
B, the Fructus Gardeniae of getting counterweight, Fructus Tribuli two flavor medicated powder is broken, the ethanol that adds 12 times decocts 3 times, and each each 3 hours, merging filtrate, filtrate is concentrated, is added in the Cortex Phellodendri concentrated solution to get medicinal liquid after filtrate recycling ethanol again;
C, with B go on foot the gained medicinal liquid concentrated after, the pharmaceutic adjuvant of suitable gel is added mixing, make gel 100 pipes.
The preparation of embodiment 4, medicament gelling agent of the present invention
Take respectively Fructus Gardeniae 300g, Fructus Tribuli 450g and Cortex Phellodendri 360g, be prepared into as follows gel:
A, the Cortex Phellodendri of getting counterweight is added the alcohol reflux 2 times of 8 times of amounts, extracted 3 hours, get filtrate, reclaim ethanol, concentrated solution is standby;
B, the Fructus Gardeniae of getting counterweight, Fructus Tribuli two flavor medicated powder is broken adds the filtering residue after Rhizoma Curcumae Longae is extracted volatile oil, and the ethanol that adds 12 times decocts 3 times, and each each 3 hours, merging filtrate, filtrate is concentrated, is added in the Cortex Phellodendri concentrated solution to get medicinal liquid after filtrate recycling ethanol again;
C, B is gone on foot the gained medicinal liquid and is condensed into dried cream after, the pharmaceutic adjuvant of suitable gel is added mixing, make gel 100 pipes.
Claims (7)
1. Chinese medicine composition that is used for the treatment of acne is characterized in that the composition of described Chinese medicine composition is by weight ratio: 30～90 parts of 10～60 parts of Cortex Phellodendris, 20～70 parts of Fructus Gardeniaes and Fructus Tribulis.
2. Chinese medicine composition according to claim 1 is characterized in that the composition of described Chinese medicine composition is by weight ratio: 45～60 parts of 20～40 parts of Cortex Phellodendris, 35～50 parts of Fructus Gardeniaes and Fructus Tribulis.
3. Chinese medicine composition according to claim 1 is characterized in that the composition of described Chinese medicine composition is by weight ratio: 50 parts of 30 parts of Cortex Phellodendris, 40 parts of Fructus Gardeniaes and Fructus Tribulis.
4. the preparation method of the described Chinese medicine composition of claims 1 to 3 any one is characterized in that Chinese medicine composition is prepared by following method:
A, take Cortex Phellodendri, Fructus Gardeniae and Fructus Tribuli by proportioning;
B, Cortex Phellodendri is added 3～12 times of water gagings or alcohol reflux 1～3 time, extracted 2～4 hours at every turn, get filtrate, reclaim ethanol, concentrated solution is standby;
C, Fructus Gardeniae, the Fructus Tribuli two flavor medicated powder of getting counterweight are broken adds 5～10 times of water or ethanol and decocts 2～5 times, and each 1～4 hour, merging filtrate, filtrate is concentrated, is added to after filtrate recycling ethanol again and gets medicinal liquid in the Cortex Phellodendri concentrated solution;
D, C is gone on foot the gained medicinal liquid add the oral liquid adjuvant to make oral liquid; Perhaps C is gone on foot the gained medicinal liquid concentrated after, carry out vacuum drying, get dry extract, then add corresponding pharmaceutic adjuvant mixing, make other oral drug preparation or external preparation.
5. Chinese medicine composition according to claim 1 is characterized in that described Chinese medicine composition is tablet, capsule, drop pill, sucks agent, granule, pill and powder.
6. Chinese medicine composition according to claim 1, is characterized in that described Chinese medicine composition is liniment, ointment, gel, spray and lotion.
7. Chinese medicine composition according to claim 1, is characterized in that the application of described Chinese medicine composition in the preparation Retinoids, Retin-A, Renova, Accutane.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 201110434583 CN103169800A (en) | 2011-12-22 | 2011-12-22 | Traditional Chinese medicine composition for treating acne and preparation method and application thereof |
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| CN 201110434583 CN103169800A (en) | 2011-12-22 | 2011-12-22 | Traditional Chinese medicine composition for treating acne and preparation method and application thereof |
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| CN103169800A true CN103169800A (en) | 2013-06-26 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113577137B (en) * | 2020-04-30 | 2024-05-28 | 湖南今汉药业有限公司 | Traditional Chinese medicine composition for treating acne and preparation method and application thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113577137B (en) * | 2020-04-30 | 2024-05-28 | 湖南今汉药业有限公司 | Traditional Chinese medicine composition for treating acne and preparation method and application thereof |
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Application publication date: 20130626 |