CN104825624A - Application of traditional Chinese medicine composition in preparation of drug for treating herpetic stommightitis - Google Patents
Application of traditional Chinese medicine composition in preparation of drug for treating herpetic stommightitis Download PDFInfo
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Abstract
The invention discloses an application of traditional Chinese medicine composition in preparation of drug for treating herpetic stommightitis and belongs to the field of application of traditional Chinese medicine. The traditional Chinese medicine composition is prepared from following medicines: fructus forsythiae, honeysuckle, ephedra, semen armeniacae amarae and the like. The traditional Chinese medicine composition is significant in treatment effects on the herpetic stommightitis.
Description
Technical field
The present invention relates to a kind of novelty teabag of Chinese medicine composition, particularly, relate to the application of a kind of Chinese medicine composition in the medicine of preparation treatment stomatitis, belong to application in TCM field.
Background technology
Herpetic stomatitis is caused by herpes simplex virus I-type infection, and be a kind of samples inflammation, be mainly in less than 6 years old child, the infant of being particularly born latter 6 months to 3 years old is more common.Onset is anxious, and sickness rate is high, falls ill without obvious calendar variation, there is no specific treatment at present.Often be apt to occur in cheek, oral mucosa and vermilion border and contiguous mouth week skin.After onset heating 1 ~ 2d, there is single or cluster herpes in each position mucosas such as gums, lip are interior, tongue, cheek mucosa, has blush around; ulcer is formed after rapid ulceration; have yellow-white cellulosic secretions to cover, because of oral ulcer causes the children's that has an intense pain usually can refusing to eat, oral mucosa is subject to inflammatory stimulus; salivation increases; increase the weight of children's's sialorrhea phenomenon, have a strong impact on diet and the health of child, the course of disease 1 ~ 2 week; a kind of commonly encountered diseases, frequently-occurring disease.
Treatment for stomatitis mainly contains and often keeps oral hygiene, and ulcer person local is coated with lignocaine, be exactly intravenous applications ribavirin in addition, but therapeutic effect is not felt quite pleased.
Summary of the invention
The present invention relates to a kind of novelty teabag of Chinese medicine composition, particularly, relate to the application of a kind of Chinese medicine composition in the medicine of preparation treatment herpetic stomatitis.
Chinese medicine of the present invention can be had the Chinese medicine of same or similar effect to replace, and these medical materials all can be concocted according to " national Chinese medicine processing specification " or " Chinese medicine voluminous dictionary ".
The object of the invention is to provide the application of a kind of Chinese medicine composition in the medicine of preparation treatment herpetic stomatitis, and described Chinese medicine composition is made up of the crude drug of following weight portion:
Fructus Forsythiae 240-280 Flos Lonicerae 240-280 Radix Isatidis 240-280 Radix Et Rhizoma Rhei 45-55
Herba Pogostemonis 70-90 Rhizoma Dryopteris Crassirhizomatis 240-280 Radix Rhodiolae 70-90 Mentholum 6-8
Herba Ephedrae 70-90 Semen Armeniacae Amarum 70-90 Herba Houttuyniae 240-280 Radix Glycyrrhizae 70-90
Gypsum Fibrosum 240-280.
Preferably, this Chinese medicine composition is made up of the crude drug of following weight portion:
Fructus Forsythiae 240 Flos Lonicerae 280 Radix Isatidis 240 Radix Et Rhizoma Rhei 55 Herba Pogostemonis 70
Rhizoma Dryopteris Crassirhizomatis 280 Radix Rhodiolae 90 Mentholum 8 Herba Ephedrae 70 Semen Armeniacae Amarum 90
Herba Houttuyniae 240 Radix Glycyrrhizae 90 Gypsum Fibrosum 240.
Or:
Fructus Forsythiae 280 Flos Lonicerae 240 Radix Isatidis 280 Radix Et Rhizoma Rhei 45 Herba Pogostemonis 90
Rhizoma Dryopteris Crassirhizomatis 240 Radix Rhodiolae 70 Mentholum 6 Herba Ephedrae 90 Semen Armeniacae Amarum 70
Herba Houttuyniae 280 Radix Glycyrrhizae 70 Gypsum Fibrosum 280.
Or:
Fructus Forsythiae 255 Flos Lonicerae 255 Radix Isatidis 255 Radix Et Rhizoma Rhei 51 Herba Pogostemonis 85
Rhizoma Dryopteris Crassirhizomatis 255 Radix Rhodiolae 85 Mentholum 7.5 Herba Ephedrae 85 Semen Armeniacae Amarum 85
Herba Houttuyniae 255 Radix Glycyrrhizae 85 Gypsum Fibrosum 255.
Preferentially, in the raw materials used medicine of described Chinese medicine composition, Herba Ephedrae is Herba ephedrae, and Semen Armeniacae Amarum is Semen Armeniacae Amarum (parched).
The active component that present invention also offers described Chinese medicine composition is made up of following steps:
(1) take Chinese crude drug according to crude drug part by weight, clean;
(2) Herba Pogostemonis is cataclasm, adds 8-10 times amount water extraction volatile oil, carries the 4 hours time of oil, collects volatile oil, for subsequent use; After extracting liquid filtering, residue discards, and filtrate is for subsequent use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei, with the ethanol extraction 2 times of 6-10 times amount 50-90%, each 1-3 hour, extracting solution merges and filters, and reclaim ethanol, filtrate is for subsequent use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae, adding 7-11 times amount soak by water to boiling, adding Semen Armeniacae Amarum, decoct 2 times, each 0.5-2.5 hour, extracting solution merges filtration, filtrate after oil carried by gained filtrate and step (2) Herba Pogostemonis merges, be condensed into 60 DEG C time measure relative density be the clear paste of 1.10-1.15, add ethanol, reconcile to determining alcohol be 70%, cold preservation is placed, filter, reclaim ethanol to without alcohol taste, obtain clear paste for subsequent use;
(5) step (4) gained gained clear paste and step (3) gained alcohol extract are merged, being concentrated into and measuring relative density 60 DEG C time is the clear paste of 1.15-1.20, and dry, get dry extract powder, for subsequent use;
Step (5) gained dried cream powder, step (2) gained volatile oil and Mentholum form the active component of this Chinese medicine composition jointly.
The dosage form of medicine of the present invention is capsule, tablet, powder, oral liquid, pill, tincture, syrup, suppository, gel, spray or injection.
For enabling above-mentioned dosage form realize, the acceptable adjuvant of pharmacy need be added when preparing these dosage forms, such as: filler, disintegrating agent, lubricant, suspending agent, binding agent, sweeting agent, correctives, antiseptic, substrate etc.Filler comprises: starch, pregelatinized Starch, lactose, mannitol, chitin, microcrystalline Cellulose, sucrose etc.; Disintegrating agent comprises: starch, pregelatinized Starch, microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose etc.; Lubricant comprises: magnesium stearate, sodium lauryl sulphate, Pulvis Talci, silicon dioxide etc.; Suspending agent comprises: polyvinylpyrrolidone, microcrystalline Cellulose, sucrose, agar, hydroxypropyl emthylcellulose etc.; Binding agent comprises, starch slurry, polyvinylpyrrolidone, hydroxypropyl emthylcellulose etc.; Sweeting agent comprises: saccharin sodium, Aspartane, sucrose, cyclamate, enoxolone etc.; Correctives comprises: sweeting agent and various essence; Antiseptic comprises: parabens, benzoic acid, sodium benzoate, sorbic acid and its esters, benzalkonium bromide, acetic acid chloroethene are fixed, Folium eucalypti globueli (Eucalyptus globulus Labill.) wet goods; Substrate comprises: PEG6000, PEG4000, insect wax etc. (Fan Biting " pharmacy of Chinese materia medica ", Shanghai Science Press. December the 1st edition in 1997. the adjuvant that each dosage form is recorded).
The wherein preparation method of capsule is made up of following steps:
(1) take Chinese crude drug according to crude drug part by weight, clean;
(2) Herba Pogostemonis is cataclasm, adds 5-8 times amount water extraction volatile oil, carries the 4 hours time of oil, collects volatile oil, for subsequent use; After extracting liquid filtering, residue discards, and filtrate is for subsequent use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei, with the ethanol extraction 2 times of 6-10 times amount 50-90%, each 1-3 hour, extracting solution merges and filters, and reclaim ethanol, filtrate is for subsequent use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae, adding 7-11 times amount soak by water to boiling, adding Semen Armeniacae Amarum, decoct 2 times, each 0.5-2.5 hour, extracting solution merges filtration, filtrate after oil carried by gained filtrate and step (2) Herba Pogostemonis merges, be condensed into 60 DEG C time measure relative density be the clear paste of 1.10-1.15, add ethanol, reconcile to determining alcohol be 70%, cold preservation is placed, filter, reclaim ethanol to without alcohol taste, obtain clear paste for subsequent use;
(5) step (4) gained gained clear paste and step (3) gained alcohol extract are merged, being concentrated into and measuring relative density 60 DEG C time is the clear paste of 1.15-1.20, and dry, get dry extract powder, for subsequent use;
(6) step (5) gained dried cream powder is added suitable pharmaceutically acceptable adjuvant to granulate;
(7) Mentholum, step (2) gained volatile oil are added dissolve with ethanol, spray into step (6) gained granule, airtight, mixing, incapsulates, to obtain final product.
The wherein preparation method of granule is made up of following steps:
(1) take Chinese crude drug according to crude drug part by weight, clean, cataclasm as one sees fit;
(2) Herba Pogostemonis is cataclasm, adds 5-8 times amount water extraction volatile oil, carries the 4 hours time of oil, collects volatile oil, for subsequent use; After extracting liquid filtering, residue discards, and filtrate is for subsequent use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei, with the ethanol extraction 2 times of 6-10 times amount 50-90%, each 1-3 hour, extracting solution merges and filters, and reclaim ethanol, filtrate is for subsequent use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae, adding 7-11 times amount soak by water to boiling, adding Semen Armeniacae Amarum, decoct 2 times, each 0.5-2.5 hour, extracting solution merges filtration, filtrate after oil carried by gained filtrate and step (2) Herba Pogostemonis merges, be condensed into 60 DEG C time measure relative density be the clear paste of 1.10-1.15, add ethanol, reconcile to determining alcohol be 70%, cold preservation is placed, filter, reclaim ethanol to without alcohol taste, obtain clear paste for subsequent use;
(5) step (4) gained gained clear paste and step (3) gained alcohol extract are merged, being concentrated into and measuring relative density 60 DEG C time is the clear paste of 1.15-1.20, and dry, get dry extract powder, for subsequent use;
(6) step (5) gained dried cream powder is added suitable pharmaceutically acceptable adjuvant to granulate;
(7) Mentholum, step (2) gained volatile oil are added dissolve with ethanol, spray into step (6) gained granule, airtight, mixing, pack, to obtain final product.
The preparation method of preferred granule is:
(1) take Chinese crude drug according to crude drug part by weight, clean, cataclasm as one sees fit;
(2) Herba Pogostemonis is cataclasm, adds 6 times amount water extraction volatile oil, carries the 4 hours time of oil, collects volatile oil, for subsequent use; After extracting liquid filtering, residue discards, and filtrate is for subsequent use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei, by the ethanol extraction 2 times of 8 times amount 70%, 2 hours first times, second time 1.5 hours, extracting solution merges and filters, and reclaim ethanol, filtrate is for subsequent use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae, adds 9 times amount soak by water to boiling, and adds Semen Armeniacae Amarum, decocts 2 times, 1.5 hours first times, second time 1 hour, extracting solution merges filtration, filter liquor after oil carried by gained filtrate and step (2) Herba Pogostemonis merges, being condensed into and measuring relative density 60 DEG C time is the clear paste of 1.10-1.15, and add 95% ethanol, being adjusted to determining alcohol is 70%, cold preservation is placed, filter, reclaim ethanol to without alcohol taste, obtain clear paste filtrate;
(5) step (4) gained clear paste filtrate and step (3) gained alcohol extract are merged, being concentrated into and measuring relative density 60 DEG C time is the clear paste of 1.15-1.20, for subsequent use;
(6) step (5) gained clear paste is added suitable pharmaceutically acceptable adjuvant to granulate;
(7) Mentholum, step (2) gained volatile oil are added dissolve with ethanol, spray into step (6) gained granule, airtight, mixing, pack, to obtain final product.
Other dosage forms of medicine of the present invention are in proportion after weighting raw materials, adopt conventional preparation method preparation, such as, the preparation technology that Fan Biting " pharmacy of Chinese materia medica " (Shanghai Science Press 1997 December the 1st edition) records, makes the acceptable regular dosage form of pharmaceutics.
Pharmaceutical composition of the present invention confirms by experiment, compositions only within the scope of each flavour of a drug of the present invention all has clear and definite antivirus action to herpesvirus, surpass compositions not this effect formed outside going beyond the scope, pharmaceutical composition of the present invention is based on " antipyretic and detoxicated ", and suitable compatibility blood circulation promoting and blood stasis dispelling, purging FU-organs heat clearing away, fragrance keep away dirty medicine.Flos Lonicerae, Fructus Forsythiae, Radix Isatidis heat-clearing and toxic substances removing; The pathogenic fire purging such as Gypsum Fibrosum, Radix Rhodiolae lung heat clearing, supplementing QI and nourishing YIN, eliminating pathogenic factor for supporting vital QI is double to be executed, and both can contain the property that its temperature is loose, and can strengthen again the effect that lung qi dispersing expels the heat-evil with Herba Ephedrae compatibility; Herba Pogostemonis, Mentholum removing dampness by means of aromatics induce sweat, and turn round and look at and protect taste.Quan Fangwei gas is ruled together, and relieving exterior-interior syndrome is integrally-regulated.Research display, there is broad-spectrum disease resistance toxic action, can significantly suppress multiple virus replication, and there is the effect improving human immunologic function, play Mutiple Targets, too many levels, multipath global advantage, herpes simplex virus type 1 (HSV-1) and 2 types virus can be suppressed.
experimental example:
For the curative effect of proved invention Drug therapy stomatitis, with the capsule (hereinafter referred to as medicine of the present invention) obtained by embodiment 1, carry out following research:
1 data and method
1.1 physical data
To the infant that in January, 2012 ~ October goes to a doctor at Hebei Yi Ling hospital outpatient, the 80 routine infants meeting herpetic stomatitis diagnostic criteria are selected to carry out observation of curative effect, 6 months ~ 6 years old age.Average 25.5 months.Infant safety is divided equally into two groups at random, treatment group and matched group are 40 examples, and matched group is A group 40 example, wherein man 16 example, female 24 example, treatment group is B group, wherein man 22 example, female 18 example, all cases all exists and generates heat in various degree, body temperature 38 ~ 39 DEG C, in lip, the position such as gums, tongue and cheek mucosa all sees herpes, falls ill to consultation time 6h ~ 2d.Illly all do not use any medicine afterwards.Two groups of children age, sex, medical time the course of disease, coincident with severity degree of condition no significant difference, there is comparability.
1.2 treatment and observational techniques
Infant safety being divided equally is at random 2 groups, matched group and treatment group.Two groups except giving vitamin C and vitamin B
2beyond support, symptomatic treatment, all give ribavirin injection (Chengdu Plain pharmaceutcal corporation, Ltd) intravenous drip 10-15mg/(kgd), divide 2 administrations, and oral Kangfuxin Liquid (Sichuan Haoyisheng Panxi Pharmaceutical Co., Ltd.), less than 3 years old each 5ml, more than 3 years old each 10ml, homogeneous day 3 times; Treatment group adds with medicine of the present invention (Shijiazhuang Yiling Pharmaceutical Co., Ltd) on this treatment basis ,≤3 years old 1 time 0.7g, 3 times on the 1st; >3 year 1 1g, 3 times on the 1st, is 5 days the course for the treatment of.
1.3 Outcome measure
Efficacy assessment standard is effective: medication is symptom and sign disappearance after 5 days, herpes of mouth place ulcer healing, and heating person's heat is moved back; Effective: medication after 5 days sings and symptoms obviously alleviate, heating person's heat is moved back, oral ulcer major part healing; Invalid: though medication after 5 days sings and symptoms alleviate, oral ulcer is without significant change, and local pain still exists, and heating person's body temperature is still higher than normally.With effective+effectively calculate total effective rate.
1.4 statistical procedures
Application SPSS 13.0 software kit carries out statistical procedures, measurement data is used (
) represent, compare between 2 groups and adopt t inspection, enumeration data percentage ratio represents, 2 groups of comparitive study adopt x
2inspection.P<0.05 represents that difference has statistical significance.
2 results
2.1 liang of group comparitive study
Two groups of total effective rates compare difference very significant (P<0.01), and two groups of obvious effective rates compare difference has significance (P<0.01) in table 1.
table 1 liang group herpetic stomatitis infant comparitive study [example (%)]
2.2 liang of group treatment herpetic stomatitis symptoms, sign extinction times compare
Treatment group adds moves back the time with medicine after heat of the present invention and herpes of mouth healing is significantly shorter than matched group (equal P<0.01) in table 2.
table 2 liang group treatment herpetic stomatitis symptom, sign extinction time compare (d,
)
2.3 untoward reaction
Two groups of patients all without leukopenia, without erythra.
In sum, pharmaceutical composition main component of the present invention forms compound preparation by 13 taste Chinese medicine reasonable compatibilities such as Fructus Forsythiae, Flos Lonicerae, Herba Ephedrae, Semen Armeniacae Amarum, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Herba Houttuyniae, Herba Pogostemonis, Radix Et Rhizoma Rhei, Radix Rhodiolae, Mentholum, Radix Glycyrrhizaes.Based on " antipyretic and detoxicated ", suitable compatibility blood circulation promoting and blood stasis dispelling, purging FU-organs heat clearing away, fragrance keep away dirty medicine.Flos Lonicerae, Fructus Forsythiae, Radix Isatidis heat-clearing and toxic substances removing; The pathogenic fire purging such as Gypsum Fibrosum, Radix Rhodiolae lung heat clearing, supplementing QI and nourishing YIN, eliminating pathogenic factor for supporting vital QI is double to be executed, and both can contain the property that its temperature is loose, and can strengthen again the effect that lung qi dispersing expels the heat-evil with Herba Ephedrae compatibility; Herba Pogostemonis, Mentholum removing dampness by means of aromatics induce sweat, and turn round and look at and protect taste.Quan Fangwei gas is ruled together, and relieving exterior-interior syndrome is integrally-regulated.Research display, has broad-spectrum disease resistance toxic action, can significantly suppress multiple virus replication, and has the effect improving human immunologic function, plays Mutiple Targets, too many levels, multipath global advantage.Confirm through clinical pharmacology, herpes simplex virus type 1 (HSV-1) and 2 types virus can be suppressed, alleviate heating, and untoward reaction is less.Consider from the aspect such as curative effect and untoward reaction, adopt pharmaceutical composition of the present invention and Western medicine antiviral drugs use in conjunction to have collaborative and potentiation.
Detailed description of the invention
embodiment 1:
crude drug formula is:
Fructus Forsythiae 255 g Flos Lonicerae 255 g Radix Isatidis 255 g Radix Et Rhizoma Rhei 51 g Herba Pogostemonis 85 g
Rhizoma Dryopteris Crassirhizomatis 255 g Radix Rhodiolae 85 g Mentholum 7.5 g Herba ephedrae 85 g
Semen Armeniacae Amarum (parched) 85 g Herba Houttuyniae 255 g Radix Glycyrrhizae 85 g Gypsum Fibrosum 255 g
preparation method is:
(1) take Chinese crude drug according to above-mentioned prescription, clean, cataclasm as one sees fit;
(2) Herba Pogostemonis is cataclasm, adds 6 times amount water extraction volatile oil, carries the 4 hours time of oil, collects volatile oil, for subsequent use; After extracting liquid filtering, residue discards, and filtrate is for subsequent use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei, by the ethanol extraction 2 times of 8 times amount 70%, 2 hours first times, second time 1.5 hours, extracting solution merges and filters, and reclaim ethanol, filtrate is for subsequent use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae, add 9 times amount soak by water to boiling, add Semen Armeniacae Amarum and decoct 2 times, 1.5 hours first times, second time 1 hour, extracting solution merges filtration, filtrate after oil carried by gained filtrate and step (2) Herba Pogostemonis merges, being condensed into and measuring relative density 60 DEG C time is the clear paste of 1.10, add ethanol, being adjusted to determining alcohol is 70%, cold preservation places 24 hours, filter, reclaim ethanol extremely without alcohol taste, gained filtrate and step (3) gained alcohol extract merge, being concentrated into and measuring relative density 60 DEG C time is the clear paste of 1.15, spraying dry, get dry extract powder, for subsequent use,
(5) step (4) gained dried cream powder is added starch 138 grams, use 85% alcohol granulation;
(6) Mentholum, step (2) gained volatile oil are added dissolve with ethanol, spray into step (5) gained granule, airtight, mixing, loads 1000 capsules, to obtain final product.
embodiment 2:
crude drug formula is:
Fructus Forsythiae 280g Flos Lonicerae 240g Radix Isatidis 280g Radix Et Rhizoma Rhei 45g Herba Pogostemonis 90g Rhizoma Dryopteris Crassirhizomatis 240g Radix Rhodiolae 70g Mentholum 6g Herba Ephedrae 90g Semen Armeniacae Amarum 70g Herba Houttuyniae 280 g Radix Glycyrrhizae 70g Gypsum Fibrosum 280 g
preparation method is:
(1) take Chinese crude drug according to above-mentioned prescription, clean, cataclasm as one sees fit;
(2) Herba Pogostemonis is cataclasm, adds 5 times amount water extraction volatile oil, carries the 4 hours time of oil, collects volatile oil, for subsequent use; After extracting liquid filtering, residue discards, and filtrate is for subsequent use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei, by the ethanol extraction 2 times of 6 times amount 50%, 3 hours first times, second time 1 hour, extracting solution merges and filters, and reclaim ethanol, filtrate is for subsequent use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae, add 7 times amount soak by water to boiling, add Semen Armeniacae Amarum and decoct 2 times, 0.5 hour first time, second time 2.5 hours, extracting solution merges filtration, filtrate after oil carried by gained filtrate and step (2) Herba Pogostemonis merges, being condensed into and measuring relative density 60 DEG C time is the clear paste of 1.15, add ethanol, being adjusted to determining alcohol is 70%, cold preservation places 24 hours, filter, reclaim ethanol extremely without alcohol taste, gained filtrate and step (3) gained alcohol extract merge, being concentrated into and measuring relative density 60 DEG C time is the clear paste of 1.20, spraying dry, get dry extract powder, for subsequent use,
(5) step (4) gained dried cream powder is added starch 134 grams, use 85% alcohol granulation;
(6) Mentholum, step (2) gained volatile oil are added dissolve with ethanol, spray into step (5) gained granule, formulation method is made tablet and be get final product routinely.
embodiment 3:
crude drug formula is:
Fructus Forsythiae 240 g Flos Lonicerae 280 g Radix Isatidis 240 g Radix Et Rhizoma Rhei 55 g Herba Pogostemonis 70 g Rhizoma Dryopteris Crassirhizomatis 280 g Radix Rhodiolae 90 g Mentholum 8 g Herba Ephedrae 70 g Semen Armeniacae Amarum 90 g Herba Houttuyniae 240 g Radix Glycyrrhizae 90 g Gypsum Fibrosum 240 g.
preparation method is:
(1) take Chinese crude drug according to above-mentioned prescription, clean, cataclasm as one sees fit;
(2) Herba Pogostemonis is cataclasm, adds 10 times amount water extraction volatile oil, carries the 4 hours time of oil, collects volatile oil, for subsequent use; After extracting liquid filtering, residue discards, and filtrate is for subsequent use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei, by the ethanol extraction 2 times of 10 times amount 90%, 1 hour first time, second time 3 hours, extracting solution merges and filters, and reclaim ethanol, filtrate is for subsequent use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae, add 11 times amount soak by water to boiling, add Semen Armeniacae Amarum and decoct 2 times, 2.5 hours first times, second time 0.5 hour, extracting solution merges filtration, filtrate after oil carried by gained filtrate and step (2) Herba Pogostemonis merges, being condensed into and measuring relative density 60 DEG C time is the clear paste of 1.12, add ethanol, being adjusted to determining alcohol is 70%, cold preservation places 24 hours, filter, reclaim ethanol extremely without alcohol taste, gained filtrate and step (3) gained alcohol extract merge, being concentrated into and measuring relative density 60 DEG C time is the clear paste of 1.16, spraying dry, get dry extract powder, for subsequent use,
(5) Mentholum, step (2) gained volatile oil are added dissolve with ethanol, spray into step (4) gained dried cream powder, formulation method is made pill and be get final product routinely.
embodiment 4:
crude drug formula is:
Fructus Forsythiae 170g Flos Lonicerae 170g Herba Ephedrae (processed) 57g Semen Armeniacae Amarum (parched) 57g
Gypsum Fibrosum 170g Radix Isatidis 170g Rhizoma Dryopteris Crassirhizomatis 170g Herba Houttuyniae 170g
Herba Pogostemonis 57g Radix Et Rhizoma Rhei 34g Radix Rhodiolae 57g Mentholum 5.0g
Radix Glycyrrhizae 57g
preparation method:
(1) extraction process:
(1) take Chinese crude drug according to above-mentioned recipe quantity, clean, cataclasm as one sees fit;
(2) Herba Pogostemonis adds 6 times amount water extraction volatile oil, and carry oil time 4h, collect volatile oil, oil yield is 0.33 ± 0.05%, and for subsequent use after extracting liquid filtering, residue discards;
(3) Fructus Forsythiae, Herba Ephedrae (processed), Herba Houttuyniae, Radix Et Rhizoma Rhei, with the ethanol extraction 2 times of 8 times amount 70%, 2 hours first times, second time 1.5 hours, extracting liquid filtering, filtrate merges, and reclaims ethanol to without alcohol taste, for subsequent use;
(4) Flos Lonicerae, Semen Armeniacae Amarum (parched), Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae, add 9 times amount soak by water to boiling, add Semen Armeniacae Amarum (parched), decoct 2 times, 1.5 hours first times, second time 1 hour, extracting liquid filtering, filtrate merge add simultaneously step (2) Herba Pogostemonis carry oil after aqueous solution, being condensed into 60 DEG C of mensuration relative densities is 1.10 clear paste, add 95% ethanol, limit edged stirs, to determining alcohol 70%, cold preservation places 24 hours, filter, filtrate recycling ethanol is extremely without alcohol taste, merge with alcohol extract, being concentrated into and being condensed into 60 DEG C of mensuration relative densities is 1.20 clear paste, for subsequent use,
(2) preparation process:
(5) pharmaceutical formulation is: step (4) gained clear paste 335.5g Mentholum 5g
Step (2) gained patchouli oil 0.2ml Icing Sugar 342.5g dextrin 514.0g
(6) granulate: by Icing Sugar and dextrin mix homogeneously, make binding agent soft material with clear paste, 14 eye mesh screens are granulated, 60-65 DEG C of oven dry, 10 eye mesh screen granulate;
(7) subpackage: sift out fine powder appropriate, Mentholum, Herba Pogostemonis Volatile oil are added ethanol in proper amount, dissolves, sprays in fine powder, mix homogeneously, and mix homogeneously with granule, airtight half an hour, and pack, obtaining final product, above prescription can be made into granule 1000g.
Claims (9)
1. the application of Chinese medicine composition in the medicine of preparation treatment herpetic stomatitis, is characterized in that described Chinese medicine composition is made up of the crude drug of following weight portion:
Fructus Forsythiae 240-280 Flos Lonicerae 240-280 Radix Isatidis 240-280 Radix Et Rhizoma Rhei 45-55
Herba Pogostemonis 70-90 Rhizoma Dryopteris Crassirhizomatis 240-280 Radix Rhodiolae 70-90 Mentholum 6-8
Herba Ephedrae 70-90 Semen Armeniacae Amarum 70-90 Herba Houttuyniae 240-280 Radix Glycyrrhizae 70-90
Gypsum Fibrosum 240-280.
2. application according to claim 1, is characterized in that described Chinese medicine composition is made up of the crude drug of following weight portion:
Fructus Forsythiae 240 Flos Lonicerae 280 Radix Isatidis 240 Radix Et Rhizoma Rhei 55 Herba Pogostemonis 70
Rhizoma Dryopteris Crassirhizomatis 280 Radix Rhodiolae 90 Mentholum 8 Herba Ephedrae 70 Semen Armeniacae Amarum 90
Herba Houttuyniae 240 Radix Glycyrrhizae 90 Gypsum Fibrosum 240.
3. application according to claim 1, is characterized in that described Chinese medicine composition is made up of the crude drug of following weight portion:
Fructus Forsythiae 280 Flos Lonicerae 240 Radix Isatidis 280 Radix Et Rhizoma Rhei 45 Herba Pogostemonis 90
Rhizoma Dryopteris Crassirhizomatis 240 Radix Rhodiolae 70 Mentholum 6 Herba Ephedrae 90 Semen Armeniacae Amarum 70
Herba Houttuyniae 280 Radix Glycyrrhizae 70 Gypsum Fibrosum 280.
4. application according to claim 1, is characterized in that described Chinese medicine composition is made up of the crude drug of following weight portion:
Fructus Forsythiae 255 Flos Lonicerae 255 Radix Isatidis 255 Radix Et Rhizoma Rhei 51 Herba Pogostemonis 85
Rhizoma Dryopteris Crassirhizomatis 255 Radix Rhodiolae 85 Mentholum 7.5 Herba Ephedrae 85 Semen Armeniacae Amarum 85
Herba Houttuyniae 255 Radix Glycyrrhizae 85 Gypsum Fibrosum 255.
5. the application according to any one of claim 1-4, is characterized in that the active component of described Chinese medicine composition is made up of following steps:
(1) take Chinese crude drug according to crude drug part by weight, clean;
(2) Herba Pogostemonis is cataclasm, adds 8-10 times amount water extraction volatile oil, carries the 4 hours time of oil, collects volatile oil, for subsequent use; After extracting liquid filtering, residue discards, and filtrate is for subsequent use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei, with the ethanol extraction 2 times of 6-10 times amount 50-90%, each 1-3 hour, extracting solution merges and filters, and reclaim ethanol, filtrate is for subsequent use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae, adding 7-11 times amount soak by water to boiling, adding Semen Armeniacae Amarum, decoct 2 times, each 0.5-2.5 hour, extracting solution merges filtration, filtrate after oil carried by gained filtrate and step (2) Herba Pogostemonis merges, be condensed into 60 DEG C time measure relative density be the clear paste of 1.10-1.15, add ethanol, reconcile to determining alcohol be 70%, cold preservation is placed, filter, reclaim ethanol to without alcohol taste, obtain clear paste for subsequent use;
(5) step (4) gained gained clear paste and step (3) gained alcohol extract are merged, being concentrated into and measuring relative density 60 DEG C time is the clear paste of 1.15-1.20, and dry, get dry extract powder, for subsequent use;
Step (5) gained dried cream powder, step (2) gained volatile oil and Mentholum form the active component of this Chinese medicine composition jointly.
6. the application according to any one of claim 1-4, is characterized in that described Chinese medicine composition dosage form is capsule, tablet, powder, granule, oral liquid, pill, tincture, syrup, suppository, gel, spray or injection.
7. application according to claim 6, is characterized in that the preparation method of described capsule is made up of following steps:
(1) take Chinese crude drug according to crude drug part by weight, clean;
(2) Herba Pogostemonis is cataclasm, adds 5-8 times amount water extraction volatile oil, carries the 4 hours time of oil, collects volatile oil, for subsequent use; After extracting liquid filtering, residue discards, and filtrate is for subsequent use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei, with the ethanol extraction 2 times of 6-10 times amount 50-90%, each 1-3 hour, extracting solution merges and filters, and reclaim ethanol, filtrate is for subsequent use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae, adding 7-11 times amount soak by water to boiling, adding Semen Armeniacae Amarum, decoct 2 times, each 0.5-2.5 hour, extracting solution merges filtration, filtrate after oil carried by gained filtrate and step (2) Herba Pogostemonis merges, be condensed into 60 DEG C time measure relative density be the clear paste of 1.10-1.15, add ethanol, reconcile to determining alcohol be 70%, cold preservation is placed, filter, reclaim ethanol to without alcohol taste, obtain clear paste for subsequent use;
(5) step (4) gained gained clear paste and step (3) gained alcohol extract are merged, being concentrated into and measuring relative density 60 DEG C time is the clear paste of 1.15-1.20, and dry, get dry extract powder, for subsequent use;
(6) step (5) gained dried cream powder is added suitable pharmaceutically acceptable adjuvant to granulate;
(7) Mentholum, step (2) gained volatile oil are added dissolve with ethanol, spray into step (6) gained granule, airtight, mixing, incapsulates, to obtain final product.
8. application according to claim 6, is characterized in that the preparation method of described granule is made up of following steps:
(1) take Chinese crude drug according to crude drug part by weight, clean, cataclasm as one sees fit;
(2) Herba Pogostemonis is cataclasm, adds 5-8 times amount water extraction volatile oil, carries the 4 hours time of oil, collects volatile oil, for subsequent use; After extracting liquid filtering, residue discards, and filtrate is for subsequent use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei, with the ethanol extraction 2 times of 6-10 times amount 50-90%, each 1-3 hour, extracting solution merges and filters, and reclaim ethanol, filtrate is for subsequent use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae, adding 7-11 times amount soak by water to boiling, adding Semen Armeniacae Amarum, decoct 2 times, each 0.5-2.5 hour, extracting solution merges filtration, filtrate after oil carried by gained filtrate and step (2) Herba Pogostemonis merges, be condensed into 60 DEG C time measure relative density be the clear paste of 1.10-1.15, add ethanol, reconcile to determining alcohol be 70%, cold preservation is placed, filter, reclaim ethanol to without alcohol taste, obtain clear paste for subsequent use;
(5) step (4) gained gained clear paste and step (3) gained alcohol extract are merged, being concentrated into and measuring relative density 60 DEG C time is the clear paste of 1.15-1.20, and dry, get dry extract powder, for subsequent use;
(6) step (5) gained dried cream powder is added suitable pharmaceutically acceptable adjuvant to granulate;
(7) Mentholum, step (2) gained volatile oil are added dissolve with ethanol, spray into step (6) gained granule, airtight, mixing, pack, to obtain final product.
9. application according to claim 8, is characterized in that the preparation method of described granule is made up of following steps:
(1) take Chinese crude drug according to crude drug part by weight, clean, cataclasm as one sees fit;
(2) Herba Pogostemonis is cataclasm, adds 6 times amount water extraction volatile oil, carries the 4 hours time of oil, collects volatile oil, for subsequent use; After extracting liquid filtering, residue discards, and filtrate is for subsequent use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei, by the ethanol extraction 2 times of 8 times amount 70%, 2 hours first times, second time 1.5 hours, extracting solution merges and filters, and reclaim ethanol, filtrate is for subsequent use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae, adds 9 times amount soak by water to boiling, and adds Semen Armeniacae Amarum, decocts 2 times, 1.5 hours first times, second time 1 hour, extracting solution merges filtration, filter liquor after oil carried by gained filtrate and step (2) Herba Pogostemonis merges, being condensed into and measuring relative density 60 DEG C time is the clear paste of 1.10-1.15, and add 95% ethanol, being adjusted to determining alcohol is 70%, cold preservation is placed, filter, reclaim ethanol to without alcohol taste, obtain clear paste filtrate;
(5) step (4) gained clear paste filtrate and step (3) gained alcohol extract are merged, being concentrated into and measuring relative density 60 DEG C time is the clear paste of 1.15-1.20, for subsequent use;
(6) step (5) gained clear paste is added suitable pharmaceutically acceptable adjuvant to granulate;
(7) Mentholum, step (2) gained volatile oil are added dissolve with ethanol, spray into step (6) gained granule, airtight, mixing, pack, to obtain final product.
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| CN109481527A (en) * | 2017-09-11 | 2019-03-19 | 石家庄以岭药业股份有限公司 | It is a kind of prepare prevention or treat mouth disease Chinese medicine composition and its application |
| CN109692138A (en) * | 2017-10-24 | 2019-04-30 | 石家庄以岭药业股份有限公司 | A kind of oral care method and its application |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103446314A (en) * | 2012-06-02 | 2013-12-18 | 北京以岭药业有限公司 | Application of traditional Chinese medicine composition to preparation of medicament for treating influenza B virus |
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| CN103446314A (en) * | 2012-06-02 | 2013-12-18 | 北京以岭药业有限公司 | Application of traditional Chinese medicine composition to preparation of medicament for treating influenza B virus |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109481527A (en) * | 2017-09-11 | 2019-03-19 | 石家庄以岭药业股份有限公司 | It is a kind of prepare prevention or treat mouth disease Chinese medicine composition and its application |
| CN109692138A (en) * | 2017-10-24 | 2019-04-30 | 石家庄以岭药业股份有限公司 | A kind of oral care method and its application |
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Application publication date: 20150812 |