CN101637533B - Application of Chinese medicinal composition in preparation of medicament for treating virus myocarditis - Google Patents
Application of Chinese medicinal composition in preparation of medicament for treating virus myocarditis Download PDFInfo
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Abstract
The invention discloses application of Chinese medicinal composition in preparation of medicament for treating virus myocarditis. The Chinese medicinal composition mainly comprises weeping forsythiae capsule, honeysuckle flower, indigowoad root, rhubarb, cablin potchouli herb, male fern rhizome, rhodiola rosea, and the like. The Chinese medicinal composition takes the advantages of integrated regulation of compound Chinese medicament, organically combines the functions of dispelling disease evil, relieving symptoms and regulating immune, realizes multi-target treatment, and is proved by clinical experiments to have remarkable effect of treating the virus myocarditis.
Description
Technical field
The present invention relates to the application of a kind of Chinese medicine composition in preparation treatment viral myocarditis medicine, belong to field of Chinese herbal.
Background technology
Viral myocarditis is that virus infringement heart causes that the myocarditis sexually transmitted disease (STD) becomes the disease of main manifestations.The most common with the various viral infection that cause intestinal and upper respiratory tract infection.Enterovirus is pico+ribonucleic acid+virus, wherein with enterovirus COxsackie, dust can, poliovirus is for causing myocarditic main virus; The leaf that myxovirus such as influenza virus, parainfluenza virus cause is not rare, the myocarditis that adenovirus also can cause, and in addition, measles, parotitis, encephalitis b, hepatitis, cytomegalovirus all may cause myocarditis.
The primary disease extent of disease is not of uniform size, can be diffusivity or limitation.Can be acute or chronic with disease.Pathological changes sees that than the severe one naked eyes cardiac muscle is very lax, gray or yellow, and the chambers of the heart enlarges.Pathological changes than the lighter when the gross examination without discovery, only find and the diagnosis of relying to some extent at microscopically, and pathological examination must be in the section of a plurality of positions, the side make pathological changes avoid omitting.At microscopically, can find cellular infiltration between the cardiac muscle fiber with in the blood vessel connective tissue all around, take mononuclear cell as main.Myocardial cell can have degeneration, dissolving or necrosis.Pathological changes becomes viral perimyocarditis as then merging pericarditis at the pericardium inferior segment.Pathological changes can relate to cardiac muscle and a matter, also can relate to pace-making and conducting system such as sinuatrial node, atrioventricular node, atrioventricular bundle and the bundle branch of heart, becomes ARR pathogenesis basis.The virulence of virus is stronger, and extent of disease is wider.In experimental myocarditis, can see myocardial necrosis afterwards by fibrous tissue replacement.
The symptom of viral myocarditis may come across symptom phase or the convalescent period of protopathy.As occurring in symptom phase of protopathy, its performance can be covered by protopathy.Most of patients has the symptoms such as heating, systemic pain, pharyngalgia, diarrhoea at premorbid, reflection general viral infection, but some patients were protopathy mild symptoms is also arranged and not remarkable, and carefully the side of questioning closely is noted, the myocarditis symptom is then more remarkable.That patients with myocarditis is often told is uncomfortable in chest, pareordia dull pain, cardiopalmus, weak, nauseating, dizzy.Clinically in the myocarditis of diagnosis, about 90% are chief complaint or head sees symptom with arrhythmia, and wherein small number of patients can occur to faint or Adams Stokes syndrome therefrom.Only a few patient rises after being ill, and development heart failure or cardiogenic shock occur rapidly.(Chen Haozhu. practical internal medicine. People's Health Publisher .1997 July the 10th edition)
Think on the Chinese medicine that viral myocarditis should belong to the epidemic febrile disease category: think that viral myocarditis is the warm poison heresy of impression or sense wind and cold, rheumatism invasion and attack human body is made is the pyretic toxicity morbidity more.Its pathogen is many to be entered from fur, mouth and nose, attacks table and invades lung or impairing the spleen and stomach, and the deficiency of the lung or stomach are hindered and caused pectoral qi and generate not enoughly or deficient, or malicious evil direct attack heart channel injures pectoral qi person.Yang-energy master liter, initiatively strong to be upgraded to, cardiopulmonary occupy high-order with reduce to and, the weak mistake department of the modest lung qi of pectoral qi is in one's own department or unit, unablely lifts cardiopulmonary and the gesture of decline is arranged or descends too, all can produce the atmospheric subsidence card because void cause to fall into.The atmospheric subsidence not only morbidity with viral myocarditis is relevant, and relevant with its symptom, sign.
The Drug therapy of viral myocarditis comprises: 1, antiviral drugs such as ribavirin, ganciclovir etc., and due to illness poison infects the different antiviral drugs of different choice; 2, immunomodulator treatment is such as adrenocortical hormone etc., but multiplex in severe cases; 3, the cardiac nutrition treatment is such as fructose diphosphate, glucose-insulin-potassium solutions etc.; 4, free radical scavenging Drug therapy such as vitamin C, vitamin E, coenzyme Q10 are present the most frequently used oxygen radical removing medicines; 5, immunoglobulin for treating; 6, treatment by Chinese herbs.
Along with Chinese medicine to the deepening constantly of viral myocarditis etiology and pathogenesis understanding, the new side's medicine of many new method for the treatment of has appearred, the western medicine of comparing, Chinese medicine is for the treatment of viral myocarditis, therapeutic effect is obvious, and untoward reaction is less.
The present invention is the improvement invention of carrying out on the basis of ZL03143211 patent, quotes in full the content of this patent document record at this.The application of unexposed this Chinese medicine composition of above-mentioned patent in preparation viral myocarditis medicine.
Summary of the invention
The invention provides the application in a kind of Chinese medicine composition preparation treatment viral myocarditis medicine, this Chinese medicine composition is made by the crude drug of following weight portion:
Fructus Forsythiae 200-300 Flos Lonicerae 200-300 Radix Isatidis 200-300 Radix Et Rhizoma Rhei 40-60
Herba Pogostemonis 60-100 Rhizoma Dryopteris Crassirhizomatis 200-300 Radix Rhodiolae 60-100 Mentholum 5-9
Herba Ephedrae 60-100 Semen Armeniacae Amarum 60-100 Herba Houttuyniae 200-300 Radix Glycyrrhizae 60-100
Gypsum Fibrosum 200-300.
The weight part ratio of the crude drug of Chinese medicine composition of the present invention is preferably:
Fructus Forsythiae 200 Flos Loniceraes 300 Radix Isatidis 200 Radix Et Rhizoma Rhei 60 Herba Pogostemonis 60
Rhizoma Dryopteris Crassirhizomatis 300 Radix Rhodiolaes 60 Mentholums 9 Herba Ephedraes 60 Semen Armeniacae Amarums 100
Herba Houttuyniae 200 Radix Glycyrrhizaes 100 Gypsum Fibrosum 200.
The weight part ratio of the crude drug of Chinese medicine composition of the present invention also is preferably:
Fructus Forsythiae 300 Flos Loniceraes 200 Radix Isatidis 300 Radix Et Rhizoma Rhei 60 Herba Pogostemonis 100
Rhizoma Dryopteris Crassirhizomatis 200 Radix Rhodiolaes 60 Mentholums 5 Herba Ephedraes 100 Semen Armeniacae Amarums 60
Herba Houttuyniae 300 Radix Glycyrrhizaes 60 Gypsum Fibrosum 300.
The weight part ratio of the crude drug of Chinese medicine composition of the present invention also is preferably:
Fructus Forsythiae 278 Flos Loniceraes 294 Radix Isatidis 285 Radix Et Rhizoma Rhei 55 Herba Pogostemonis 95
Rhizoma Dryopteris Crassirhizomatis 290 Radix Rhodiolaes 287 Mentholums 8.5 Herba Ephedraes 88 Semen Armeniacae Amarums 80
Herba Houttuyniae 284 Radix Glycyrrhizaes 95 Gypsum Fibrosum 277.
The weight part ratio of the crude drug of Chinese medicine composition of the present invention also is preferably:
Fructus Forsythiae 255 Flos Loniceraes 255 Radix Isatidis 255 Radix Et Rhizoma Rhei 51 Herba Pogostemonis 85
Rhizoma Dryopteris Crassirhizomatis 255 Radix Rhodiolaes 85 Mentholums 7.5 Herba Ephedraes 85 Semen Armeniacae Amarum (parched) 85
Herba Houttuyniae 255 Radix Glycyrrhizaes 85 Gypsum Fibrosum 255.
Drug main of the present invention will be comprised of Fructus Forsythiae, Flos Lonicerae, Radix Isatidis, Radix Et Rhizoma Rhei, Herba Pogostemonis, Rhizoma Dryopteris Crassirhizomatis, Radix Rhodiolae etc., the integrally-regulated advantage of performance herbal mixture, and antiviral has significant curative effect for the treatment viral myocarditis.
Chinese medicine of the present invention can be had the Chinese medicine of same or similar effect fruit to replace, and these medical materials all can be concocted according to " national Chinese medicine processing standard " or " Chinese medicine voluminous dictionary ".
The active component of Chinese medicine composition of the present invention is made by following steps:
(1) takes by weighing Chinese crude drug according to the crude drug part by weight, clean;
(2) Herba Pogostemonis is cataclasm, adds 5-8 times of water gaging and extracts volatile oil, carries the 4 hours time of oil, collects volatile oil, and is for subsequent use; Behind the extracting liquid filtering, residue discards, filtrate for later use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei are doubly measured the ethanol extraction 2 times of 50-90% with 6-10, and each 1-3 hour, extracting solution merged and filters Recycled ethanol, filtrate for later use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae add 7-11 times of water gaging and decoct to boiling, and add Semen Armeniacae Amarum, decoct 2 times, each 0.5-2.5 hour,, extracting solution merges filtration, the filtrate that gained filtrate and step (2) Herba Pogostemonis is carried behind the oil merges, being condensed into and measuring relative density in the time of 60 ℃ is the clear paste of 1.10-1.15, adds ethanol, and being adjusted to determining alcohol is 70%, cold preservation is placed, filter, Recycled ethanol is to distinguishing the flavor of without alcohol, and it is for subsequent use to get clear paste;
(5) step (4) gained clear paste and step (3) gained alcohol extract are merged, being concentrated into and measuring relative density in the time of 60 ℃ is the clear paste of 1.15-1.20, drying, and the powder that gets dry extract, for subsequent use;
Step (5) gained dried cream powder, step (2) gained volatile oil and Mentholum consist of the active component of this Chinese medicine composition jointly.
The dosage form of medicine of the present invention is capsule, tablet, powder, granule, oral liquid, soft capsule, pill, tincture, syrup, suppository, gel, spray or injection.
For above-mentioned dosage form can be realized, need when these dosage forms of preparation, to add the acceptable adjuvant of pharmacy, such as: filler, disintegrating agent, lubricant, suspending agent, binding agent, sweeting agent, correctives, antiseptic, substrate etc.Filler comprises: starch, pregelatinized Starch, lactose, mannitol, chitin, microcrystalline Cellulose, sucrose etc.; Disintegrating agent comprises: starch, pregelatinized Starch, microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose etc.; Lubricant comprises: magnesium stearate, sodium lauryl sulphate, Pulvis Talci, silicon dioxide etc.; Suspending agent comprises: polyvinylpyrrolidone, microcrystalline Cellulose, sucrose, agar, hydroxypropyl emthylcellulose etc.; Binding agent comprises, starch slurry, polyvinylpyrrolidone, hydroxypropyl emthylcellulose etc.; Sweeting agent comprises: saccharin sodium, Aspartane, sucrose, cyclamate, enoxolone etc.; Correctives comprises: sweeting agent and various essence; Antiseptic comprises: parabens, benzoic acid, sodium benzoate, sorbic acid and its esters, benzalkonium bromide, fixed, the Folium eucalypti globueli (Eucalyptus globulus Labill.) wet goods of acetic acid chloroethene; Substrate comprises: PEG6000, PEG4000, insect wax etc.
Wherein capsule is made by following steps:
(1) takes by weighing Chinese crude drug according to the crude drug part by weight, clean;
(2) Herba Pogostemonis is cataclasm, adds 5-8 times of water gaging and extracts volatile oil, carries the 4 hours time of oil, collects volatile oil, and is for subsequent use; Behind the extracting liquid filtering, residue discards, filtrate for later use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei are doubly measured the ethanol extraction 2 times of 50-90% with 6-10, and each 1-3 hour, extracting solution merged and filters Recycled ethanol, filtrate for later use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae add 7-11 times of water gaging and decoct to boiling, and add Semen Armeniacae Amarum, decoct 2 times, each 0.5-2.5 hour,, extracting solution merges filtration, the filtrate that gained filtrate and step (2) Herba Pogostemonis is carried behind the oil merges, being condensed into and measuring relative density in the time of 60 ℃ is the clear paste of 1.10-1.15, adds ethanol, and being adjusted to determining alcohol is 70%, cold preservation is placed, filter, Recycled ethanol is to distinguishing the flavor of without alcohol, and it is for subsequent use to get clear paste;
(5) step (4) gained clear paste and step (3) gained alcohol extract merge, and being concentrated into and measuring relative density in the time of 60 ℃ is the clear paste of 1.15-1.20, drying, and the powder that gets dry extract, for subsequent use;
(6) step (5) gained dried cream powder being added suitable pharmaceutically acceptable adjuvant granulates;
(7) Mentholum, step (2) gained volatile oil are added dissolve with ethanol, spray into step (6) gained granule, airtight, mixing incapsulates, and get final product.
The preparation method of granule wherein is to be made by following steps:
(1) take by weighing Chinese crude drug according to the crude drug part by weight, clean, cataclasm as one sees fit;
(2) Herba Pogostemonis is cataclasm, adds 5-8 times of water gaging and extracts volatile oil, carries the 4 hours time of oil, collects volatile oil, and is for subsequent use; Behind the extracting liquid filtering, residue discards, filtrate for later use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei are doubly measured the ethanol extraction 2 times of 50-90% with 6-10, and each 1-3 hour, extracting solution merged and filters Recycled ethanol, filtrate for later use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae add 7-11 times of water gaging and decoct to boiling, and add Semen Armeniacae Amarum, decoct 2 times, each 0.5-2.5 hour, extracting solution merged filtration, the filtrate that gained filtrate and step (2) Herba Pogostemonis is carried behind the oil merges, being condensed in the time of 60 ℃ and measuring relative density is the clear paste of 1.10-1.15, adds ethanol, reconcile to determining alcohol be 70%, cold preservation is placed, filter, Recycled ethanol is to distinguishing the flavor of without alcohol, and it is for subsequent use to get clear paste;
(5) step (4) gained gained clear paste and step (3) gained alcohol extract are merged, being concentrated into and measuring relative density in the time of 60 ℃ is the clear paste of 1.15-1.20, drying, and the powder that gets dry extract, for subsequent use;
(6) step (5) gained dried cream powder being added suitable pharmaceutically acceptable adjuvant granulates;
(7) Mentholum, step (2) gained volatile oil are added dissolve with ethanol, spray into step (6) gained granule, airtight, mixing, pack, and get final product.
The preparation method of preferred granule is:
(1) take by weighing Chinese crude drug according to the crude drug part by weight, clean, cataclasm as one sees fit;
(2) Herba Pogostemonis is cataclasm, adds 6 times of water gagings and extracts volatile oil, carries the 4 hours time of oil, collects volatile oil, and is for subsequent use; Behind the extracting liquid filtering, residue discards, filtrate for later use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei, with 8 times of amount ethanol extractions of 70% 2 times, 2 hours for the first time, 1.5 hours for the second time, extracting solution merged and filters Recycled ethanol, filtrate for later use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae add 9 times of water gagings and decoct to boiling, and add Semen Armeniacae Amarum, decoct 2 times, 1.5 hours for the first time, 1 hour for the second time, extracting solution merged filtration, the filter liquor that gained filtrate and step (2) Herba Pogostemonis is carried behind the oil merges, being condensed into and measuring relative density in the time of 60 ℃ is the clear paste of 1.10-1.15, adds 95% ethanol, and being adjusted to determining alcohol is 70%, cold preservation is placed, filter, Recycled ethanol gets clear paste filtrate to without the alcohol flavor;
(5) step (4) gained clear paste filtrate and step (3) gained alcohol extract are merged, be concentrated into and in the time of 60 ℃, measure relative density and be the thick paste of 1.25-1.35, for subsequent use;
(6) step (5) gained thick paste being added suitable pharmaceutically acceptable adjuvant granulates;
(7) Mentholum, step (2) gained volatile oil are added dissolve with ethanol, spray into step (6) gained granule, airtight, mixing, pack, and get final product.
The preparation method of other dosage forms of medicine of the present invention is: weighting raw materials in proportion, adopt conventional preparation method preparation, for example, the preparation technology of Fan Biting " pharmacy of Chinese materia medica " (Shanghai Science Press 1997 December the 1st edition) record makes the acceptable regular dosage form of pharmaceutics.
The specific embodiment
Following embodiment is used for illustrating the preparation of medicine of the present invention, but it can not consist of any restriction to scope of the present invention.
Embodiment 1
Prescription:
Fructus Forsythiae 255 gram Flos Loniceraes 255 gram Radix Isatidis 255 gram Radix Et Rhizoma Rhei 51 grams
Herba Pogostemonis 85 gram Rhizoma Dryopteris Crassirhizomatiss 255 gram Radix Rhodiolaes 85 gram Mentholums 7.5 grams
Herba Ephedrae 85 gram Semen Armeniacae Amarum (parched) 85 gram Herba Houttuyniae 255 gram Radix Glycyrrhizaes 85 grams
Gypsum Fibrosum 255 grams.
Preparation method:
(1) takes by weighing Chinese crude drug according to above-mentioned prescription, clean;
(2) Herba Pogostemonis is cataclasm, adds 6 times of water gagings and extracts volatile oil, carries the 4 hours time of oil, collects volatile oil, and is for subsequent use; Behind the extracting liquid filtering, residue discards, filtrate for later use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei, with 8 times of amount ethanol extractions of 70% 2 times, 2 hours for the first time, 1.5 hours for the second time, extracting solution merged and filters Recycled ethanol, filtrate for later use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae add 9 times of water gagings and decoct to boiling, and add Semen Armeniacae Amarum, decoct 2 times, 1.5 hours for the first time, 1 hour for the second time, extracting solution merged filtration, the filtrate that gained filtrate and step (2) Herba Pogostemonis is carried behind the oil merges, being condensed into and measuring relative density in the time of 60 ℃ is the clear paste of 1.10-1.15, adds ethanol, and being adjusted to determining alcohol is 70%, cold preservation was placed 24 hours, filter, Recycled ethanol is to distinguishing the flavor of without alcohol, and it is for subsequent use to get clear paste;
(5) step (4) gained clear paste and step (3) gained alcohol extract merge, and being concentrated into and measuring relative density in the time of 60 ℃ is the clear paste of 1.15-1.20, spray drying, and the powder that gets dry extract, for subsequent use;
(6) step (5) gained dried cream powder is added starch 142 grams, use 85% alcohol granulation;
(7) Mentholum, step (2) gained volatile oil are added dissolve with ethanol, spray into step (6) gained granule, airtight, mixing, 1000 capsules of packing into, and get final product.
Embodiment 2
Prescription:
Fructus Forsythiae 200 gram Flos Loniceraes 300 gram Radix Isatidis 200 gram Radix Et Rhizoma Rhei 60 grams
Herba Pogostemonis 60 gram Rhizoma Dryopteris Crassirhizomatiss 300 gram Radix Rhodiolaes 60 gram Mentholums 9 grams
Herba Ephedrae 60 gram Semen Armeniacae Amarums 100 gram Herba Houttuyniae 200 gram Radix Glycyrrhizaes 100 grams
Gypsum Fibrosum 200 grams.
Preparation method:
(1) takes by weighing Chinese crude drug according to above-mentioned prescription, clean;
(2) Herba Pogostemonis is cataclasm, adds 5 times of water gagings and extracts volatile oil, carries the 4 hours time of oil, collects volatile oil, and is for subsequent use; Behind the extracting liquid filtering, residue discards, filtrate for later use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei, with 6 times of amount ethanol extractions of 50% 2 times, 1 hour for the first time, 2.5 hours for the second time, extracting solution merged and filters Recycled ethanol, filtrate for later use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae add 7 times of water gagings and decoct to boiling, and add Semen Armeniacae Amarum, decoct 2 times, 1.5 hours for the first time, 1 hour for the second time, extracting solution merged filtration, the filtrate that gained filtrate and step (2) Herba Pogostemonis is carried behind the oil merges, being condensed into and measuring relative density in the time of 60 ℃ is the clear paste of 1.10-1.15, adds ethanol, and being adjusted to determining alcohol is 70%, cold preservation was placed 24 hours, filter, Recycled ethanol is to distinguishing the flavor of without alcohol, and it is for subsequent use to get clear paste;
(5) step (4) gained clear paste and step (3) gained alcohol extract are merged, being concentrated into and measuring relative density in the time of 60 ℃ is the clear paste of 1.15-1.20, spray drying, and the powder that gets dry extract, for subsequent use;
(6) step (5) gained dried cream powder is added starch 151 grams, use 85% alcohol granulation;
(7) Mentholum, step (2) gained volatile oil are added dissolve with ethanol, spray into step (6) gained granule, airtight, mixing, compacting gets 935 in flakes.
Embodiment 3
Prescription:
Fructus Forsythiae 300 gram Flos Loniceraes 200 gram Radix Isatidis 300 gram Radix Et Rhizoma Rhei 60 grams
Herba Pogostemonis 100 gram Rhizoma Dryopteris Crassirhizomatiss 200 gram Radix Rhodiolaes 60 gram Mentholums 5 grams
Herba Ephedrae 100 gram Semen Armeniacae Amarums 60 gram Herba Houttuyniae 300 gram Radix Glycyrrhizaes 60 grams
Gypsum Fibrosum 300 grams.
Preparation method:
(1) takes by weighing Chinese crude drug according to above-mentioned prescription, clean;
(2) Herba Pogostemonis is cataclasm, adds 8 times of water gagings and extracts volatile oil, carries the 4 hours time of oil, collects volatile oil, and is for subsequent use; Behind the extracting liquid filtering, residue discards, filtrate for later use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei, with 10 times of amount ethanol extractions of 90% 2 times, 3 hours for the first time, 2.5 hours for the second time, extracting solution merged and filters Recycled ethanol, filtrate for later use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae add 11 times of water gagings and decoct to boiling, and add Semen Armeniacae Amarum, decoct 2 times, 1.5 hours for the first time, 1 hour for the second time, extracting solution merged filtration, the filtrate that gained filtrate and step (2) Herba Pogostemonis is carried behind the oil merges, being condensed into and measuring relative density in the time of 60 ℃ is the clear paste of 1.10-1.15, adds ethanol, and being adjusted to determining alcohol is 70%, cold preservation was placed 24 hours, filter, Recycled ethanol is to distinguishing the flavor of without alcohol, and it is for subsequent use to get clear paste;
(5) step (4) gained clear paste and step (3) gained alcohol extract merge, and being concentrated into and measuring relative density in the time of 60 ℃ is the clear paste of 1.15-1.20, spray drying, and the powder that gets dry extract, for subsequent use;
(6) with step (5) gained dried cream powder, step (2) gained volatile oil and Mentholum are made pill according to a conventional method, get pill 905 balls.
Embodiment 4:
The crude drug prescription is:
Fructus Forsythiae 170g Flos Lonicerae 170g Herba Ephedrae (processing) 57g Semen Armeniacae Amarum (stir-fry) 57g
Gypsum Fibrosum 170g Radix Isatidis 170g Rhizoma Dryopteris Crassirhizomatis 170g Herba Houttuyniae 170g
Herba Pogostemonis 57g Radix Et Rhizoma Rhei 34g Radix Rhodiolae 57g Mentholum 5.0g
Radix Glycyrrhizae 57g
Preparation method:
(1) extraction process:
(1) take by weighing Chinese crude drug according to above-mentioned recipe quantity, clean, cataclasm as one sees fit;
(2) Herba Pogostemonis adds 6 times of water gagings extraction volatile oil, carries oil time 4h, collects volatile oil, and oil yield is 0.33 ± 0.05%, and for subsequent use behind the extracting liquid filtering, residue discards;
(3) Fructus Forsythiae, Herba Ephedrae (processed), Herba Houttuyniae, Radix Et Rhizoma Rhei, with 8 times of amount ethanol extractions of 70% 2 times, 2 hours for the first time, 1.5 hours for the second time, extracting liquid filtering, filtrate merges, and Recycled ethanol is to without the alcohol flavor, and is for subsequent use;
(4) Flos Lonicerae, Semen Armeniacae Amarum (parched), Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae, adding 9 times of water gagings decocts to boiling, add Semen Armeniacae Amarum (parched), decoct 2 times, 1.5 hours for the first time, 1 hour for the second time, extracting liquid filtering, filtrate merging adds the aqueous solution after step (2) Herba Pogostemonis is carried oil simultaneously, and being condensed into 60 ℃ of mensuration relative densities is the 1.10-1.15 clear paste, adds 95% ethanol, the limit edged stirs, to determining alcohol 70%, cold preservation was placed 24 hours, filtered, filtrate recycling ethanol is to distinguishing the flavor of without alcohol, merge with alcohol extract, be concentrated into and be condensed into 60 ℃ and measure relative densities and be the 1.25-1.35 thick paste, for subsequent use;
(2) preparation process:
(5) pharmaceutical formulation is: step (4) gained thick paste 335.5g Mentholum 5g
Step (2) gained patchouli oil 0.2ml Icing Sugar 342.5g dextrin 514.0g
(6) granulate: with Icing Sugar and dextrin mix homogeneously, make binding agent soft material processed with thick paste, 14 eye mesh screens are granulated, 60-65 ℃ of oven dry, 10 eye mesh screen granulate;
(7) packing: it is an amount of to sift out fine powder, and Mentholum, Herba Pogostemonis Volatile oil are added an amount of ethanol, and dissolving sprays in the fine powder, mix homogeneously, and with the granule mix homogeneously, airtight half an hour, pack and get final product, more than prescription can be made into granule 1000g.
Experimental example:
Be the myocarditic curative effect of proved invention medicine therapeutic virus, use the capsule (hereinafter referred to as medicine of the present invention) that makes by embodiment 1 method, carried out following clinical experimental study:
1 data and method
1.1 physical data Hebei Yi Ling Patients during Hospital Ward is divided into treatment group and matched group by randomly assigne.Treatment group 30 examples, male 16 examples, women 14 examples, age 16-45 year, average 28.7 ± 3.9 years old; Course of disease 3-12 days, average 7.0 ± 1.8 days.Electrocardioscopy all has in various degree unusual, I Aminophyline 5 examples wherein, and Frequent atrial premature beats secondary 6 examples, frequent premature ventricular beats 20 examples, the S-T that leads more than 2 is horizontal type and moves down 〉=0.05mV person's 10 examples.Matched group 30 examples, male 17 examples, women 13 examples, age 16-48 year, average 27.5 ± 0.9 years old; Course of disease 3-12 days, average 7.0 ± 0.7 days; Electrocardioscopy all has in various degree unusual, I Aminophyline 6 examples wherein, and Frequent atrial premature beats secondary 6 examples, frequent premature ventricular beats 19 examples, the S-T section of leading more than 2 are horizontal type and move down 〉=0.05mV person's 12 examples.By statistics, two groups at aspect there was no significant differences (P＞0.05) such as sex, age, the course of disease, the state of an illness, has comparability.
1.2 case is selected inclusion criteria: meet the diagnostic criteria of viral myocarditis in " the Quality for disease entities control criterion " that in February, 1992, Ministry of Public Health was formulated.Exclusion standard: except the myocarditis that causes of the factor such as hyperthyroidism, rheumatism, hypertension, poisoning.
1.3 the conventional western medicine of using of Therapeutic Method matched group, intravenous drip Energy mixture (10% Fructus Vitis viniferae solution 500ml, coenzyme A100U, adenosine triphosphate 20mg, inosine 0.4g, vitamin C 0.3g) once a day.The mexiletine sheet, 150mg, oral, every day 3 times.Treatment group adds on the matched group basis uses medicine of the present invention, and 4 tablets/times, 3 times/days.Be 1 month the course for the treatment of.
1.4 observation index: observe the variation for the treatment of front and back myocardial enzymes [serum creatine hydrogen kinases (CPK), aspartic acid transferring enzyme (AST) and serum lactate dehydrogenase (SLD) (LDH)].
1.5 curative effect determinate standard: formulate with reference to " new drug (Chinese medicine) treatment viral myocarditis guideline of clinical investigations ".Clinical cure: clinical symptoms, sign disappear, and it is normal that electrocardiogram and lab testing recover; Produce effects; Clinical symptoms, sign disappear substantially, and it is normal that electrocardiogram and lab testing recover substantially; Effectively; Clinical symptoms, sign make moderate progress, and electrocardiogram and lab testing indices have some improvement; Invalid; Clinical symptoms, sign and electrocardiogram, lab testing are all without improving.
1.6 statistical procedures adopts the SPSS13.0 statistical software to carry out date processing, (x ± s) expression adopts the t check to measurement data, and enumeration data adopts x with mean ± standard deviation
2Check.
2 results
2.1 Clinical efficacy comparison by statistics, treatment group patient's total effective rate is apparently higher than matched group (P＜0.05).The results are shown in Table 1.
Table 1 liang group patient clinical curative effect is (%) relatively
Annotate: * and # be x relatively
2=4.32, P＜0.05.
2.2 the variation for the treatment of front and back myocardial enzymes by statistics, treatment group is compared with matched group, and CPK, AST and LDH all obviously reduce (P＜0.05).The results are shown in Table 2.
The comparison of table 2 liang group myocardial enzymes in patients spectrum (x ± s)
Annotate: * and # be P＜0.05 relatively.
3 conclusions
This research is on the basis of doctor trained in Western medicine conventional therapy, add Drug therapy of the present invention, all be better than simple western medical treatment at aspects such as improving clinical efficacy, reduction CPK, AST and LDH content, fully proved invention medicine has significant clinical efficacy to viral myocarditis.
Claims (10)
1. the application of Chinese medicine composition in preparation treatment viral myocarditis medicine is characterized in that being made by the crude drug of following weight portion:
Fructus Forsythiae 200-300 Flos Lonicerae 200-300 Radix Isatidis 200-300 Radix Et Rhizoma Rhei 40-60
Herba Pogostemonis 60-100 Rhizoma Dryopteris Crassirhizomatis 200-300 Radix Rhodiolae 60-100 Mentholum 5-9
Herba Ephedrae 60-100 Semen Armeniacae Amarum 60-100 Herba Houttuyniae 200-300 Radix Glycyrrhizae 60-100
Gypsum Fibrosum 200-300.
2. application according to claim 1 is characterized in that being made by the crude drug of following weight portion:
Fructus Forsythiae 200 Flos Loniceraes 300 Radix Isatidis 200 Radix Et Rhizoma Rhei 60 Herba Pogostemonis 60
Rhizoma Dryopteris Crassirhizomatis 300 Radix Rhodiolaes 60 Mentholums 9 Herba Ephedraes 60 Semen Armeniacae Amarums 100
Herba Houttuyniae 200 Radix Glycyrrhizaes 100 Gypsum Fibrosum 200.
3. application according to claim 1 is characterized in that being made by the crude drug of following weight portion:
Fructus Forsythiae 300 Flos Loniceraes 200 Radix Isatidis 300 Radix Et Rhizoma Rhei 60 Herba Pogostemonis 100
Rhizoma Dryopteris Crassirhizomatis 200 Radix Rhodiolaes 60 Mentholums 5 Herba Ephedraes 100 Semen Armeniacae Amarums 60
Herba Houttuyniae 300 Radix Glycyrrhizaes 60 Gypsum Fibrosum 300.
4. application according to claim 1 is characterized in that being made by the crude drug of following weight portion:
Fructus Forsythiae 278 Flos Loniceraes 294 Radix Isatidis 285 Radix Et Rhizoma Rhei 55 Herba Pogostemonis 95
Rhizoma Dryopteris Crassirhizomatis 290 Radix Rhodiolaes 287 Mentholums 8.5 Herba Ephedraes 88 Semen Armeniacae Amarums 80
Herba Houttuyniae 284 Radix Glycyrrhizaes 95 Gypsum Fibrosum 277.
5. application according to claim 1 is characterized in that being made by the crude drug of following weight portion:
Fructus Forsythiae 255 Flos Loniceraes 255 Radix Isatidis 255 Radix Et Rhizoma Rhei 51 Herba Pogostemonis 85
Rhizoma Dryopteris Crassirhizomatis 255 Radix Rhodiolaes 85 Mentholums 7.5 Herba Ephedraes 85 Semen Armeniacae Amarum (parched) 85
Herba Houttuyniae 255 Radix Glycyrrhizaes 85 Gypsum Fibrosum 255.
6. according to claim 1-5 each described application is characterized in that the active component of described Chinese medicine composition is made by following steps:
(1) takes by weighing Chinese crude drug according to the crude drug part by weight, clean;
(2) Herba Pogostemonis is cataclasm, adds 5-8 times of water gaging and extracts volatile oil, carries the 4 hours time of oil, collects volatile oil, and is for subsequent use; Behind the extracting liquid filtering, residue discards, filtrate for later use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei are doubly measured the ethanol extraction 2 times of 50-90% with 6-10, and each 1-3 hour, extracting solution merged and filters Recycled ethanol, filtrate for later use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae add 7-11 times of water gaging and decoct to boiling, and add Semen Armeniacae Amarum, decoct 2 times, each 0.5-2.5 hour,, extracting solution merges filtration, the filtrate that gained filtrate and step (2) Herba Pogostemonis is carried behind the oil merges, being condensed into and measuring relative density in the time of 60 ℃ is the clear paste of 1.10-1.15, adds ethanol, and being adjusted to determining alcohol is 70%, cold preservation is placed, filter, Recycled ethanol is to distinguishing the flavor of without alcohol, and it is for subsequent use to get clear paste;
(5) step (4) gained clear paste and step (3) gained alcohol extract are merged, being concentrated into and measuring relative density in the time of 60 ℃ is the clear paste of 1.15-1.20, drying, and the powder that gets dry extract, for subsequent use;
Step (5) gained dried cream powder, step (2) gained volatile oil and Mentholum consist of the active component of this Chinese medicine composition jointly.
7. according to claim 1-5 each described application, the preparation formulation that it is characterized in that this Chinese medicine composition is capsule, tablet, powder, granule, oral liquid, pill, tincture or syrup.
8. application according to claim 7 is characterized in that described capsule is to be made by following steps:
(1) takes by weighing Chinese crude drug according to the crude drug part by weight, clean;
(2) Herba Pogostemonis is cataclasm, adds 5-8 times of water gaging and extracts volatile oil, carries the 4 hours time of oil, collects volatile oil, and is for subsequent use; Behind the extracting liquid filtering, residue discards, filtrate for later use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei are doubly measured the ethanol extraction 2 times of 50-90% with 6-10, and each 1-3 hour, extracting solution merged and filters Recycled ethanol, filtrate for later use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae add 7-11 times of water gaging and decoct to boiling, and add Semen Armeniacae Amarum, decoct 2 times, each 0.5-2.5 hour,, extracting solution merges filtration, the filtrate that gained filtrate and step (2) Herba Pogostemonis is carried behind the oil merges, being condensed into and measuring relative density in the time of 60 ℃ is the clear paste of 1.10-1.15, adds ethanol, and being adjusted to determining alcohol is 70%, cold preservation is placed, filter, Recycled ethanol is to distinguishing the flavor of without alcohol, and it is for subsequent use to get clear paste;
(5) step (4) gained clear paste and step (3) gained alcohol extract merge, and being concentrated into and measuring relative density in the time of 60 ℃ is the clear paste of 1.15-1.20, drying, and the powder that gets dry extract, for subsequent use;
(6) step (5) gained dried cream powder being added suitable pharmaceutically acceptable adjuvant granulates;
(7) Mentholum, step (2) gained volatile oil are added dissolve with ethanol, spray into step (6) gained granule, airtight, mixing incapsulates, and get final product.
9. application according to claim 7 is characterized in that described granule is to be made by following steps:
(1) take by weighing Chinese crude drug according to the crude drug part by weight, clean, cataclasm as one sees fit;
(2) Herba Pogostemonis is cataclasm, adds 5-8 times of water gaging and extracts volatile oil, carries the 4 hours time of oil, collects volatile oil, and is for subsequent use; Behind the extracting liquid filtering, residue discards, filtrate for later use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei are doubly measured the ethanol extraction 2 times of 50-90% with 6-10, and each 1-3 hour, extracting solution merged and filters Recycled ethanol, filtrate for later use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae add 7-11 times of water gaging and decoct to boiling, and add Semen Armeniacae Amarum, decoct 2 times, each 0.5-2.5 hour, extracting solution merged filtration, the filtrate that gained filtrate and step (2) Herba Pogostemonis is carried behind the oil merges, being condensed in the time of 60 ℃ and measuring relative density is the clear paste of 1.10-1.15, adds ethanol, reconcile to determining alcohol be 70%, cold preservation is placed, filter, Recycled ethanol is to distinguishing the flavor of without alcohol, and it is for subsequent use to get clear paste;
(5) step (4) gained gained clear paste and step (3) gained alcohol extract are merged, being concentrated into and measuring relative density in the time of 60 ℃ is the clear paste of 1.15-1.20, drying, and the powder that gets dry extract, for subsequent use;
(6) step (5) gained dried cream powder being added suitable pharmaceutically acceptable adjuvant granulates;
(7) Mentholum, step (2) gained volatile oil are added dissolve with ethanol, spray into step (6) gained granule, airtight, mixing, pack, and get final product.
10. application according to claim 9 is characterized in that described granule is to be made by following steps:
(1) take by weighing Chinese crude drug according to the crude drug part by weight, clean, cataclasm as one sees fit;
(2) Herba Pogostemonis is cataclasm, adds 6 times of water gagings and extracts volatile oil, carries the 4 hours time of oil, collects volatile oil, and is for subsequent use; Behind the extracting liquid filtering, residue discards, filtrate for later use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei, with 8 times of amount ethanol extractions of 70% 2 times, 2 hours for the first time, 1.5 hours for the second time, extracting solution merged and filters Recycled ethanol, filtrate for later use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae add 9 times of water gagings and decoct to boiling, and add Semen Armeniacae Amarum, decoct 2 times, 1.5 hours for the first time, 1 hour for the second time, extracting solution merged filtration, the filter liquor that gained filtrate and step (2) Herba Pogostemonis is carried behind the oil merges, being condensed into and measuring relative density in the time of 60 ℃ is the clear paste of 1.10-1.15, adds 95% ethanol, and being adjusted to determining alcohol is 70%, cold preservation is placed, filter, Recycled ethanol gets clear paste filtrate to without the alcohol flavor;
(5) step (4) gained clear paste filtrate and step (3) gained alcohol extract are merged, be concentrated into and in the time of 60 ℃, measure relative density and be the thick paste of 1.25-1.35, for subsequent use;
(6) step (5) gained thick paste being added suitable pharmaceutically acceptable adjuvant granulates;
(7) Mentholum, step (2) gained volatile oil are added dissolve with ethanol, spray into step (6) gained granule, airtight, mixing, pack, and get final product.
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