CN101850025B - Foot bathing effervescent tablets for warming and invigorating kidney deficiency - Google Patents
Foot bathing effervescent tablets for warming and invigorating kidney deficiency Download PDFInfo
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- CN101850025B CN101850025B CN2010101797893A CN201010179789A CN101850025B CN 101850025 B CN101850025 B CN 101850025B CN 2010101797893 A CN2010101797893 A CN 2010101797893A CN 201010179789 A CN201010179789 A CN 201010179789A CN 101850025 B CN101850025 B CN 101850025B
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Abstract
The invention relates to a Chinese medicinal compound preparation, in particular to foot bathing effervescent tablets for warming and invigorating kidney deficiency. The foot bathing effervescent tablets mainly comprise active ingredients, effervescent excipient and adhesive. The foot bathing effervescent tablets are characterized in that the active ingredient consists of 10 to 40 percent of prepared rehmannia rhizome powder and water extracts of the following raw material medicaments in percentage by weight: 8 to 30 percent of actinolite, 5 to 20 percent of cinnamon, 8 to 30 percent of common cnidium fruit, 8 to 30 percent of dodder, 8 to 30 percent of gordon euryale seed and 5 to 20 percent of fennel. The foot bathing effervescent tablets can adjust the functions of internal organs, and have the effects of nourishing liver and kidney and warming and invigorating kidney deficiency.
Description
Technical field
The present invention relates to medicinal preparation, be specifically related to a kind of compound Chinese medicinal preparation.
Background technology
Suffer from a deficiency of the kidney and refer to kidney vital essence negative and positive deficiency.The kind of suffering from a deficiency of the kidney of traditional Chinese medical science indication has a lot, and wherein modal is deficiency of the kidney yin, insufficiency of kidney-YANG.The symptom of suffering from a deficiency of the kidney: the symptom of insufficiency of kidney-YANG is the soreness of waist, cold extremities, fear of cold, and sexual function is bad, even also has edema, that is to say the symptom that shows as " trembling with fear "; The symptom of deficiency of the kidney yin is " heat ", mainly contains the soreness of waist, scorching, night sweat, sweating due to debility, dizziness, tinnitus etc.Incidence rate is higher owing to suffer from a deficiency of the kidney, and this just requires must be popular to its means of prevention and method, to satisfy the numerous crowd demand that suffers from a deficiency of the kidney.Therefore, seek that a kind of can to bring into play the popular again method of preventing and treating of suffering from a deficiency of the kidney of tcm characteristic be desirability.
The Chinese medicine of existing warming and invigorating kidney deficiency is in the majority with oral formulations, and first pass effect is difficult to avoid, and takes bigger side effect for a long time.The tradition traditional Chinese medical science thinks that human five internal organs's six internal organs all have corresponding echo area on foot, and foot is the terminal of 6 meridians of human body, and more than 60 acupuncture point arranged.Therefore, adopt dipping pedicure a kind of desirable selection of can yet be regarded as.When bathing foot, both can make the effective ingredient Transdermal absorption of medicine, but the holographic echo area in effective stimulus vola again, thus regulate function, strengthening vital QI to eliminate pathogenic factors reaches the effect of building body.The product of at present commercially available dipping pedicure is powder and packed dosage form, form by direct pulverizing of medicine, the effective ingredient stripping of medicine is slow, and the especially fully stripping of effective ingredient of medicine under the acceptable water temperature of human body has obviously reduced bioavailability.
For the abundant technical problem of stripping of the effective ingredient that solves medicine under the acceptable water temperature of human body, the patent application that is disclosed as CN1947684A has disclosed a kind of " effervescence tablets for feet-washing ", this effervescence tablets for feet-washing comprises the organic acid that accounts for gross mass 20%-40%, the sodium bicarbonate of 20-40%, the surfactant of 0.2-2.0% and the lubricant of 0.1%-5%, it is characterized in that: described Chinese medicine effervescence tablets for feet-washing also contains the Oleum Curcumae that accounts for gross mass 1-10%, 3-10% Radix Sophorae Flavescentis, 5-30% sodium chloride and an amount of binding agent.Raw material of Chinese medicine in the described scheme of above-mentioned patent application is Oleum Curcumae and Radix Sophorae Flavescentis, by the description of its description as can be known, described Radix Sophorae Flavescentis crude drug just just has been used as medicine through pulverizing, although therefore made effervescent tablet, dissolve rapidly in the time of making tablet meet water, but still fully stripping rapidly of the effective ingredient in the Radix Sophorae Flavescentis material powder under the acceptable water temperature of human body.In addition, limit, report that from its description and effect experiment visible described effervescence tablets for feet-washing is by the antibacterial anti-inflammatory anti-itch of realizing although the theme of above-mentioned patent application scheme does not carry out purposes.
Summary of the invention
In view of there is above-mentioned deficiency in prior art, technical problem to be solved by this invention provides a kind of foot-bath effervescent tablet of warming and invigorating kidney deficiency.
The technical scheme that the present invention addresses the above problem is as described below:
A kind of foot-bath effervescent tablet of warming and invigorating kidney deficiency, this foot-bath effervescent tablet mainly is made up of active ingredient, effervescent excipient and binding agent, it is characterized in that, described active ingredient is to be made up of 10%～40% the Radix Rehmanniae Preparata powder and the water extract of following crude drug by the percentage by weight of crude drug: Actinolitum 8%-30%, Cortex Cinnamomi 5%-20%, Fructus Cnidii 8%-30%, Semen Cuscutae 8%-30%, Semen Euryales 8%-30%, Fructus Foeniculi 5%-20%.
Foot-bath effervescent tablet of the present invention, wherein said active ingredient better is to be made up of 16.08%～32.50% the Radix Rehmanniae Preparata powder and the water extract of following crude drug by the percentage by weight of crude drug: Actinolitum 14.05%～25.00%, Cortex Cinnamomi 8.04%～16.25%, Fructus Cnidii 12.46%～24.50%, Semen Cuscutae 12.46%～24.50%, Semen Euryales 12.46%～24.50%, Fructus Foeniculi 8.04%～16.25%; The percentage by weight of preferably pressing crude drug is made up of 19.6% the Radix Rehmanniae Preparata powder and the water extract of following crude drug: Actinolitum 16.3%, Cortex Cinnamomi 9.7%, Fructus Cnidii 14.9%, Semen Cuscutae 14.9%, Semen Euryales 14.9%, Fructus Foeniculi 9.7%.
Foot-bath effervescent tablet of the present invention, wherein said active ingredient can adopt this area water extracting method commonly used to prepare, the method that the inventor recommends is as described below: get Actinolitum, Cortex Cinnamomi, Fructus Cnidii, Semen Cuscutae, Semen Euryales and Fructus Foeniculi by proportioning, add 6-10 times of water gaging earlier, decocted 1.5-3 hour, and filtered; Filtering residue adds 6-10 times of water gaging again, decocts 1.5-3 hour, filters; Merge filtrate twice, concentrate, be drying to obtain.
Foot-bath effervescent tablet of the present invention, wherein said effervescent excipient is acid source and alkali source commonly used, wherein, described acid source is one or more in citric acid, tartaric acid, fumaric acid, adipic acid and the malic acid; Described alkali source is one or more in sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate and the calcium carbonate.Above-mentioned acid source is the best with citric acid or tartaric acid.Above-mentioned alkali source is the best with sodium carbonate, sodium bicarbonate or potassium bicarbonate.
Foot-bath effervescent tablet of the present invention, wherein said binding agent are a kind of or two or more in PEG4000～6000 of isopropyl alcohol, alcoholic solution and low relative molecular mass of hypromellose aqueous solution, PVP ethanol (water) solution, olefin(e) acid resin aqueous solution, starch slurry, ethanol, syrup, isopropyl alcohol, PEG (12000～20000).
Foot-bath effervescent tablet of the present invention, can also add the lubricant of being convenient to granulate according to the production technology needs, described lubricant is a kind of or two or more in Macrogol 4000, polyethylene glycol 6000, sodium lauryl sulphate, Stepanol MG, L-leucine, sodium benzoate, enuatrol, sodium chloride, sodium acetate, boric acid, magnesium stearate, Pulvis Talci, micropowder silica gel, sucrose fatty acid ester and the sodium stearyl fumarate.
Foot-bath effervescent tablet of the present invention can also add other adjuvant commonly used, as, filler, foaming agent are or/and correctives, and wherein, described filler is one or more in starch, microcrystalline Cellulose, dextrin lactose, mannitol, sucrose and the glucose; Described foaming agent is a kind of or two or more in tween 80, sodium lauryl sulphate and the hexadecanol; Described correctives is one or more in Oleum menthae, Oleum Rosae Rugosae, Fructus Citri Limoniae oil, apple essence, flavoring orange essence, Oleum Anisi Stellati and the flavoring banana essence.
Foot-bath effervescent tablet of the present invention is a kind of pharmaceutical preparation commonly used, and the selection of its adjuvant and preparation method can be implemented with reference to " the technical study overview of Chinese medicine effervescent tablet " literary composition of " traditional medicine " 2008 the 17th volumes the 10th phase the 72nd page of publication.
Suffer from a deficiency of the kidney and mainly be divided into deficiency of the kidney yin and insufficiency of kidney-YANG.Deficiency of the kidney yin: cardinal symptom is a soreness of the waist and knees, dysphoria with feverish sensation in the chest palms and soles, more have following all diseases: vertigo and tinnitus, emaciated physique, insomnia and dreamful sleep, flushed cheek with hectic fever, night sweat, dry pharynx, impotence in male, the seminal emission premature ejaculation, women's infrequent menstruation, amenorrhea, metrorrhagia, infertile, short urination is helvolus.Insufficiency of kidney-YANG shows as that pale complexion or pitch-dark, waist knee joint ache, lassitude, brothers are ice-cold, fear of cold aversion to wind, diarrhoea, edema of the body etc., impotence in male premature ejaculation, symptom such as that the woman can occur is infertile, the enuresis, edema, hyposexuality.Cause that the factor of suffering from a deficiency of the kidney is numerous, it mainly contains following several respects: congenital defect, disorder of emotion, excess of sexual intercourse, worn with age etc.Active ingredient of the present invention is made by Actinolitum, Cortex Cinnamomi, Fructus Cnidii, Semen Cuscutae, Semen Euryales, Radix Rehmanniae Preparata and Fructus Foeniculi, and its monarch drug is Actinolitum, Radix Rehmanniae Preparata, Semen Cuscutae, has warming the kidney to invigorate YANG, a merit of the yin nourishing of enriching blood, life essence-filling, marrow-benefitting; Ministerial drug is Cortex Cinnamomi, Fructus Cnidii, Semen Euryales, and it is supporing yang to mend fire, and let the fire back to its origin, cold expelling stimulate the menstrual flow, the controlling nocturnal emission with astringent drugs reducing urination; Adjuvant drug is a Fructus Foeniculi, the warming kidney for dispelling cold of regulating the flow of vital energy.By full side's seven flavor medicine, the monarch drug warming the kidney to invigorate YANG, it is supporing yang that ministerial drug is mended fire, and assistant is to regulate the flow of vital energy, to reach the effect of warming the kidney to invigorate YANG.
Foot-bath effervescent tablet of the present invention is put into water, under the effect of gas-producing disintegrant, at once producing a large amount of bubbles (carbon dioxide) rolls tablet up and down in water, quicken its disintegrate and thawing, and then make the rapid stripping of active ingredient in the tablet, when bathing foot, but the effective ingredient Transdermal absorption, regulate function, and then realize the purpose of warming and invigorating kidney deficiency.
Following clinical experiment further specifies the advantage and the technique effect that can reach of the foot-bath effervescent tablet of warming and invigorating kidney deficiency of the present invention.
Clinical experiment
One, physical data
All cases are the patient that the sexual impotence symptom is arranged, male's 30 examples, age 30-58 year; Women's 30 examples, 30～55 years old age.Be divided at random and bathe foot group 30 examples (male 15 examples, women 15 examples); Blank group 30 examples (male 15 examples, women 15 examples).Treat preceding two groups of patients' sex, age, sexual impotence symptom integral there are no significant difference (P＞0.05), have comparability.
Two, include standard in
Penis anorthosis during sexual intercourse, or it is not hard to erect, consequently 75% chance can not be finished normal sexual intercourse, and the course of disease is more than three months.
Three, method
Bathe the foot group: the hot water of 10 of the foot-bath effervescent tablets of embodiment 1 being put into 4 liters 38～40 ℃ is bathed foot, and each 30 minutes, once a day, continuous 2 weeks.
Blank group: bathe foot with 4 liters 38～40 ℃ clear water, each 30 minutes, once a day, continuous 2 weeks.
Four, observation of curative effect
The clinical symptoms standards of grading: with primary symptom erection degree, inferior disease soreness of the waist and knees, the cold sperm lingering diarrhea, hyposexuality, four aspects are that leading indicator is marked, wherein the primary symptom code of points is: the normal note of erection degree 0 minute; Penis can erect during sexual intercourse, can go into vagina, but can not finish normal sexual intercourse note 2 minutes; Penis can erect, but not hard note 4 minutes; Penis anorthosis note 6 minutes.Inferior disease Integral Rule is: no soreness of the waist and knees is counted 0 fen, and the random thoughts soreness of the waist and knees is counted 1 fen, and normal soreness of the waist and knees is counted 2 fens, and the persistence soreness of the waist and knees is unable counts 3 fens; No cold sperm lingering diarrhea is counted 0 fen, and the lingering diarrhea of random thoughts cold sperm is counted 1 fen, and the Chang Jingleng lingering diarrhea is counted 2 fens, and the lingering diarrhea of persistence cold sperm is counted 3 fens; No libido goes down and counts 0 fen, and the random thoughts hyposexuality is counted 1 fen, and perseverance is desired to go down and counted 2 fens, and the persistence hyposexuality is counted 3 fens.Respectively at bathe foot begin before and bathe the efficacy assessment standard of marking when foot finishes:
Produce effects: erection is hard, and total mark is reduced to 70～94%.
Effectively: erection is harder, and total mark is reduced to 30～69%.
Invalid: erection improves not obvious, and total mark reduces below 30%.
Statistical procedures: total data adopts SPSS 13.0 statistics softwares to carry out statistical analysis, measurement data mean ± standard deviation (x ± s) expression.Symptom score more all adopted the t check before and after two groups of experimenters bathed foot, and two groups of experimenter's clinical efficacies relatively adopt X
2Check.
Four. result of the test:
The clinical symptoms integration relatively sees Table 1 before and after foot bath group and the blank group; Curative effect relatively sees Table 2; The improvement of cardinal symptom sign relatively sees Table 3.As known from Table 2, bathing foot group effect organizes apparently higher than blank.N in table 1～table 3 represents number.
Clinical symptoms was marked relatively (x ± s divides) before and after table 1 a liang group was bathed foot
| Group | n | Before bathing foot | After bathing foot |
| Bathe the foot group | 30 | 10.49±5.13 | 6.47±3.92a?b |
| Blank group | 30 | 10.64±5.12 | 9.65±3.93 |
Foot bath is preceding compares with bath foot back: Pa＜0.05; Bathe foot group bath foot back and bathe the foot back relatively: Pb＜0.05 with blank the group
Table 2 liang group curative effect relatively
The foot group bathed by table 3 and blank group cardinal symptom sign is improved relatively
Foot bath is preceding compares with bath foot back: Pa＜0.05; Bathe foot group bath foot back and bathe the foot back relatively: Pb＜0.05 with blank the group
The specific embodiment
Embodiment 1
Prescription:
Crude drug: Actinolitum 978g, Cortex Cinnamomi 582g, Fructus Cnidii 894g, Semen Cuscutae 894g, Semen Euryales 894g, Radix Rehmanniae Preparata 1176g, Fructus Foeniculi 582g;
Adjuvant: Oleum menthae (in right amount), Fructus Citri Limoniae 600g (in anhydride), sodium bicarbonate 780g, polyethylene glycol 6000 120g.
Method for making:
More than seven the flavor, get Radix Rehmanniae Preparata and be ground into fine powder, sieve; All the other Six-element medical materials decoct with water twice, add for the first time 8 times of water gagings, add 6 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), adds 7/10 Radix Rehmanniae Preparata fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, sodium bicarbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid fine powder that adds, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Radix Rehmanniae Preparata fine powder, spray into Oleum menthae, add polyethylene glycol 6000, mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 2
Prescription:
Crude drug: Actinolitum 600g, Cortex Cinnamomi 343g, Fructus Cnidii 811g, Semen Cuscutae 1046g, Semen Euryales 1280g, Radix Rehmanniae Preparata 1387g, Fructus Foeniculi 533g;
Adjuvant: citric acid 300g (in anhydride), fumaric acid 300g, sodium bicarbonate 480g, sodium carbonate 300g, polyethylene glycol 6000 100g, Macrogol 4000 40g.
Method for making:
More than seven the flavor, get Radix Rehmanniae Preparata and be ground into fine powder, sieve; All the other Six-element medical materials decoct with water twice, add for the first time 10 times of water gagings, add 10 times of water gagings, each 2 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), adds 7/10 Radix Rehmanniae Preparata fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Radix Rehmanniae Preparata fine powder, add polyethylene glycol 6000, the Macrogol 4000 mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 3
Prescription:
Crude drug: Actinolitum 862g, Cortex Cinnamomi 300g, Fructus Cnidii 537g, Semen Cuscutae 820g, Semen Euryales 1056g, Radix Rehmanniae Preparata 1725g, Fructus Foeniculi 700g;
Adjuvant: citric acid 300g (in anhydride), fumaric acid 300g, sodium bicarbonate 480g, sodium carbonate 300g, polyethylene glycol 6000 100g, Macrogol 4000 30g, sodium lauryl sulphate 10g, mannitol 100g, Oleum menthae, Oleum Rosae Rugosae (in right amount)
Method for making:
More than seven the flavor, get Radix Rehmanniae Preparata and be ground into fine powder, sieve; All the other Six-element medical materials decoct with water twice, add for the first time 6 times of water gagings, add 6 times of water gagings, each 1.5 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), adds 6/10 Radix Rehmanniae Preparata fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Radix Rehmanniae Preparata fine powder, spray into Oleum menthae, Oleum Rosae Rugosae, add polyethylene glycol 6000, Macrogol 4000, sodium lauryl sulphate, the mannitol mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 4
Prescription:
Crude drug: Actinolitum 1136g, Cortex Cinnamomi 568g, Fructus Cnidii 480g, Semen Cuscutae 566g, Semen Euryales 864g, Radix Rehmanniae Preparata 1477g, Fructus Foeniculi 909g;
Adjuvant: citric acid 300g (in anhydride), fumaric acid 300g, sodium bicarbonate 480g, sodium carbonate 300g, polyethylene glycol 6000 100g, Macrogol 4000 30g, sodium lauryl sulphate 10g, Pulvis Talci 10g, mannitol 100g, Oleum menthae, Oleum Rosae Rugosae, Fructus Citri Limoniae oil (in right amount).
Method for making:
More than seven the flavor, get Radix Rehmanniae Preparata and be ground into fine powder, sieve; All the other Six-element medical materials decoct with water twice, add for the first time 8 times of water gagings, add 6 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), adds 5/10 Radix Rehmanniae Preparata fine powder, mixing, 90 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 90 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Radix Rehmanniae Preparata fine powder, spray into Oleum menthae, Oleum Rosae Rugosae, Fructus Citri Limoniae oil, add polyethylene glycol 6000, Macrogol 4000, sodium lauryl sulphate, Pulvis Talci, the mannitol mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 5
Prescription:
Crude drug: Actinolitum 1392g, Cortex Cinnamomi 754g, Fructus Cnidii 882g, Semen Cuscutae 480g, Semen Euryales 578g, Radix Rehmanniae Preparata 1160g, Fructus Foeniculi 754g;
Adjuvant: tartaric acid 500g, fumaric acid 500g, adipic acid 500g, sodium bicarbonate 1200g, polyethylene glycol 6000 120g, sodium chloride 50g.
Method for making:
More than seven the flavor, get Radix Rehmanniae Preparata and be ground into fine powder, sieve; All the other Six-element medical materials decoct with water twice, add for the first time 8 times of water gagings, add 6 times of water gagings, each 2 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), adds 5/10 Radix Rehmanniae Preparata fine powder, mixing, 70 ℃ of dryings are ground into fine powder, sieve.Tartaric acid, fumaric acid, adipic acid, sodium bicarbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a tartaric acid, fumaric acid, the adipic acid fine powder of adding, mixing is made granule, 70 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Radix Rehmanniae Preparata fine powder, add polyethylene glycol 6000, sodium chloride, mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 6
Prescription:
Crude drug: Actinolitum 1179g, Cortex Cinnamomi 943g, Fructus Cnidii 1155g, Semen Cuscutae 896g, Semen Euryales 480g, Radix Rehmanniae Preparata 758g, Fructus Foeniculi 589g;
Adjuvant: citric acid 300g (in anhydride), fumaric acid 300g, sodium bicarbonate 600g, sodium carbonate 600g, polyethylene glycol 6000 100g, Macrogol 4000 40g, starch 50g, microcrystalline Cellulose 50g, tween 80 1g.
Method for making:
More than seven the flavor, get Radix Rehmanniae Preparata and be ground into fine powder, sieve; All the other Six-element medical materials decoct with water twice, add for the first time 9 times of water gagings, add 8 times of water gagings, each 2.5 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), adds 6/10 Radix Rehmanniae Preparata fine powder, mixing, 70 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 70 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 70 ℃ of dryings, No. two sieve granulate; Get residue Radix Rehmanniae Preparata fine powder, add polyethylene glycol 6000, Macrogol 4000, starch, microcrystalline Cellulose, the tween 80 mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 7
Prescription:
Crude drug: Actinolitum 917g, Cortex Cinnamomi 745g, Fructus Cnidii 1375g, Semen Cuscutae 1123g, Semen Euryales 871g, Radix Rehmanniae Preparata 600g, Fructus Foeniculi 369g;
Adjuvant: citric acid 300g (in anhydride), fumaric acid 300g, sodium bicarbonate 580g, sodium carbonate 400g, polyethylene glycol 6000 100g, Macrogol 4000 30g, sodium lauryl sulphate 10g, mannitol 100g, Oleum menthae (in right amount).
Method for making:
More than seven the flavor, get Radix Rehmanniae Preparata and be ground into fine powder, sieve; All the other Six-element medical materials decoct with water twice, add for the first time 8 times of water gagings, add 7 times of water gagings, each 2 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), adds 7/10 Radix Rehmanniae Preparata fine powder, mixing, 85 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 85 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 85 ℃ of dryings, No. two sieve granulate; Get residue Radix Rehmanniae Preparata fine powder, spray into Oleum menthae, add polyethylene glycol 6000, Macrogol 4000, sodium lauryl sulphate, the mannitol mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 8
Prescription:
Crude drug: Actinolitum 612g, Cortex Cinnamomi 546g, Fructus Cnidii 1070g, Semen Cuscutae 1310g, Semen Euryales 1070g, Radix Rehmanniae Preparata 1092g, Fructus Foeniculi 300g;
Adjuvant: citric acid 400g (in anhydride), fumaric acid 300g, sodium bicarbonate 580g, sodium carbonate 400g, polyethylene glycol 6000 100g, Macrogol 4000 30g, sodium lauryl sulphate 10g, Pulvis Talci 10g, mannitol 100g, Oleum menthae (in right amount).
Method for making:
More than seven the flavor, get Radix Rehmanniae Preparata and be ground into fine powder, sieve; All the other Six-element medical materials decoct with water twice, add for the first time 8 times of water gagings, add 6 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), adds 6/10 Radix Rehmanniae Preparata fine powder, mixing, 60 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 60 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 60 ℃ of dryings, No. two sieve granulate; Get residue Radix Rehmanniae Preparata fine powder, spray into Oleum menthae, add polyethylene glycol 6000, Macrogol 4000, sodium lauryl sulphate, Pulvis Talci, the mannitol mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 9
Prescription:
Crude drug: Actinolitum 608g, Cortex Cinnamomi 541g, Fructus Cnidii 1061g, Semen Cuscutae 1299g, Semen Euryales 1061g, Radix Rehmanniae Preparata 1082g, Fructus Foeniculi 348g;
Adjuvant: Oleum menthae (in right amount), citric acid 1200g (in anhydride), calcium carbonate 600g, Polyethylene Glycol 5000 120g.
Method for making:
More than seven the flavor, get Radix Rehmanniae Preparata and be ground into fine powder, sieve; All the other Six-element medical materials decoct with water twice, add for the first time 8 times of water gagings, add 7 times of water gagings, each 2 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), adds 7/10 Radix Rehmanniae Preparata fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, calcium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid fine powder that adds, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds the calcium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Radix Rehmanniae Preparata fine powder, spray into Oleum menthae, add Polyethylene Glycol 5000, mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 10
Prescription:
Crude drug: Actinolitum 600g, Cortex Cinnamomi 343g, Fructus Cnidii 810g, Semen Cuscutae 1046g, Semen Euryales 1280g, Radix Rehmanniae Preparata 1387g, Fructus Foeniculi 534g;
Adjuvant: citric acid 600g (in anhydride), adipic acid 600g, sodium bicarbonate 300g, calcium carbonate 300g, polyethylene glycol 6000 100g, Polyethylene Glycol 5000 40g.
Method for making:
More than seven the flavor, get Radix Rehmanniae Preparata and be ground into fine powder, sieve; All the other Six-element medical materials decoct with water twice, add for the first time 8 times of water gagings, add 6 times of water gagings, each 2 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), adds 7/10 Radix Rehmanniae Preparata fine powder, mixing, 75 ℃ of dryings are ground into fine powder, sieve.Citric acid, adipic acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the adipic acid fine powder of adding, mixing is made granule, 75 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and calcium carbonate fine powder, and mixing is made granule, 75 ℃ of dryings, No. two sieve granulate; Get residue Radix Rehmanniae Preparata fine powder, add polyethylene glycol 6000, Polyethylene Glycol 5000 mixings are crossed 80 mesh sieves, add above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 11
Prescription:
Crude drug: Actinolitum 856g, Cortex Cinnamomi 344g, Fructus Cnidii 533g, Semen Cuscutae 813g, Semen Euryales 1048g, Radix Rehmanniae Preparata 1711g, Fructus Foeniculi 695g;
Adjuvant: citric acid 400g (in anhydride), fumaric acid 800g, sodium bicarbonate 200g, sodium carbonate 400g, Polyethylene Glycol 5000 100g, Macrogol 4000 30g sodium lauryl sulphate 10g, mannitol 100g, Oleum menthae (in right amount).
Method for making:
More than seven the flavor, get Radix Rehmanniae Preparata and be ground into fine powder, sieve; All the other Six-element medical materials decoct with water twice, add for the first time 8 times of water gagings, add 7 times of water gagings, each 2 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), adds 5/10 Radix Rehmanniae Preparata fine powder, mixing, 75 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Radix Rehmanniae Preparata fine powder, spray into Oleum menthae, add Polyethylene Glycol 5000, Macrogol 4000, sodium lauryl sulphate, the mannitol mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 12
Prescription:
Crude drug: Actinolitum 1120g, Cortex Cinnamomi 560g, Fructus Cnidii 558g, Semen Cuscutae 558g, Semen Euryales 852g, Radix Rehmanniae Preparata 1456g, Fructus Foeniculi 896g;
Adjuvant: citric acid 900g (in anhydride), fumaric acid 300g, sodium bicarbonate 100g, potassium carbonate 500g, polyethylene glycol 6000 100g, Polyethylene Glycol 5000 30g, sodium lauryl sulphate 10g, Pulvis Talci 10g, mannitol 100g, Oleum menthae (in right amount).
Method for making:
More than seven the flavor, get Radix Rehmanniae Preparata and be ground into fine powder, sieve; All the other Six-element medical materials decoct with water twice, add for the first time 9 times of water gagings, add 8 times of water gagings, each 2 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), adds 6/10 Radix Rehmanniae Preparata fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and potassium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and potassium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Radix Rehmanniae Preparata fine powder, spray into Oleum menthae, add polyethylene glycol 6000, Macrogol 4000, sodium lauryl sulphate, Pulvis Talci, the mannitol mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 13
Prescription:
Crude drug: Actinolitum 1370g, Cortex Cinnamomi 742g, Fructus Cnidii 867g, Semen Cuscutae 569g, Semen Euryales 569g, Radix Rehmanniae Preparata 1141g, Fructus Foeniculi 742g;
Adjuvant: Oleum Rosae Rugosae (in right amount), citric acid 900g (in anhydride), sodium bicarbonate 900g, Polyethylene Glycol 5000 120g.
Method for making:
More than seven the flavor, get Radix Rehmanniae Preparata and be ground into fine powder, sieve; All the other Six-element medical materials decoct with water twice, add for the first time 9 times of water gagings, add 6 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), adds 7/10 Radix Rehmanniae Preparata fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, sodium bicarbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid fine powder that adds, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Radix Rehmanniae Preparata fine powder, spray into Oleum Rosae Rugosae, add Polyethylene Glycol 5000, mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 14
Prescription:
Crude drug: Actinolitum 1158g, Cortex Cinnamomi 926g, Fructus Cnidii 1135g, Semen Cuscutae 880g, Semen Euryales 577g, Radix Rehmanniae Preparata 745g, Fructus Foeniculi 579g;
Adjuvant: citric acid 450g (in anhydride), fumaric acid 450g, sodium bicarbonate 480g, sodium carbonate 420g, Polyethylene Glycol 5000 100g, polyethylene glycol 6000 40g.
Method for making:
More than seven the flavor, get Radix Rehmanniae Preparata and be ground into fine powder, sieve; All the other Six-element medical materials decoct with water twice, add for the first time 8 times of water gagings, add 6 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), adds 7/10 Radix Rehmanniae Preparata fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Radix Rehmanniae Preparata fine powder, add polyethylene glycol 6000, Polyethylene Glycol 5000 mixings are crossed 80 mesh sieves, add above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 15
Prescription:
Crude drug: Actinolitum 896g, Cortex Cinnamomi 728g, Fructus Cnidii 1345g, Semen Cuscutae 1098g, Semen Euryales 852g, Radix Rehmanniae Preparata 721g, Fructus Foeniculi 360g;
Adjuvant: citric acid 600g (in anhydride), fumaric acid 300g, sodium bicarbonate 600g, sodium carbonate 300g, polyethylene glycol 6000 100g, Macrogol 4000 30g, sodium lauryl sulphate 10g, glucose 100g, Oleum menthae (in right amount).
Method for making:
More than seven the flavor, get Radix Rehmanniae Preparata and be ground into fine powder, sieve; All the other Six-element medical materials decoct with water twice, add for the first time 8 times of water gagings, add 6 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), adds 7/10 Radix Rehmanniae Preparata fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Radix Rehmanniae Preparata fine powder, spray into Oleum menthae, add polyethylene glycol 6000, Macrogol 4000, sodium lauryl sulphate, the glucose mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 16
Prescription:
Crude drug: Actinolitum 906g, Cortex Cinnamomi 736g, Fructus Cnidii 1359g, Semen Cuscutae 1110g, Semen Euryales 861g, Radix Rehmanniae Preparata 728g, Fructus Foeniculi 300g;
Adjuvant: citric acid 500g (in anhydride), adipic acid 400g, sodium bicarbonate 4000g, sodium carbonate 500g, Polyethylene Glycol 5000 100g, Macrogol 4000 30g, sodium lauryl sulphate 10g, hexadecanol 10g, Pulvis Talci 10g, mannitol 100g, Oleum menthae, Oleum Rosae Rugosae (in right amount).
Method for making:
More than seven the flavor, get Radix Rehmanniae Preparata and be ground into fine powder, sieve; All the other Six-element medical materials decoct with water twice, add for the first time 8 times of water gagings, add 8 times of water gagings, each 2 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), adds 7/10 Radix Rehmanniae Preparata fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, adipic acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the adipic acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Radix Rehmanniae Preparata fine powder, spray into Oleum menthae, Oleum Rosae Rugosae, add Polyethylene Glycol 5000, Macrogol 4000, sodium lauryl sulphate, hexadecanol, Pulvis Talci, the mannitol mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 17
Prescription:
Crude drug: Actinolitum 600g, Cortex Cinnamomi 542g, Fructus Cnidii 1062g, Semen Cuscutae 1300g, Semen Euryales 1062g, Radix Rehmanniae Preparata 1084g, Fructus Foeniculi 350g;
Adjuvant: Oleum menthae (in right amount), citric acid 600g (in anhydride), potassium bicarbonate 1200g, Polyethylene Glycol 5000 120g.
Method for making:
More than seven the flavor, get Radix Rehmanniae Preparata and be ground into fine powder, sieve; All the other Six-element medical materials decoct with water twice, add for the first time 7 times of water gagings, add 7 times of water gagings, each 2 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), adds 7/10 Radix Rehmanniae Preparata fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, potassium bicarbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid fine powder that adds, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds the potassium bicarbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Radix Rehmanniae Preparata fine powder, spray into Oleum menthae, add Polyethylene Glycol 5000, mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 18
Prescription:
Crude drug: Actinolitum 604g, Cortex Cinnamomi 300g, Fructus Cnidii 816g, Semen Cuscutae 1054g, Semen Euryales 1290g, Radix Rehmanniae Preparata 1398g, Fructus Foeniculi 538g;
Adjuvant: citric acid 300g (in anhydride), fumaric acid 300g, sodium bicarbonate 600g, sodium carbonate 600g, polyethylene glycol 6000 100g, Macrogol 4000 40g.
Method for making:
More than seven the flavor, get Radix Rehmanniae Preparata and be ground into fine powder, sieve; All the other Six-element medical materials decoct with water twice, add for the first time 8 times of water gagings, add 8 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), adds 7/10 Radix Rehmanniae Preparata fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Radix Rehmanniae Preparata fine powder, add polyethylene glycol 6000, the Macrogol 4000 mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 19
Prescription:
Crude drug: Actinolitum 864g, Cortex Cinnamomi 347g, Fructus Cnidii 480g, Semen Cuscutae 821g, Semen Euryales 1058g, Radix Rehmanniae Preparata 1728g, Fructus Foeniculi 702g;
Adjuvant: citric acid 100g (in anhydride), fumaric acid 500g, sodium bicarbonate 900g, potassium carbonate 300g, polyethylene glycol 6000 100g, Macrogol 4000 30g, sodium lauryl sulphate 10g, mannitol 100g, Oleum Rosae Rugosae (in right amount).
Method for making:
More than seven the flavor, get Radix Rehmanniae Preparata and be ground into fine powder, sieve; All the other Six-element medical materials decoct with water twice, add for the first time 8 times of water gagings, add 7 times of water gagings, each 1.5 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), adds 7/10 Radix Rehmanniae Preparata fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and potassium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Radix Rehmanniae Preparata fine powder, spray into Oleum Rosae Rugosae, add polyethylene glycol 6000, Macrogol 4000, sodium lauryl sulphate, the mannitol mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 20
Prescription:
Crude drug: Actinolitum 1136g, Cortex Cinnamomi 568g, Fructus Cnidii 566g, Semen Cuscutae 480g, Semen Euryales 864g, Radix Rehmanniae Preparata 1477g, Fructus Foeniculi 909g;
Adjuvant: citric acid 500g (in anhydride), adipic acid 100g, sodium bicarbonate 200g, sodium carbonate 1000g, polyethylene glycol 6000 100g, Macrogol 4000 30g, sodium lauryl sulphate 10g, Pulvis Talci 10g, mannitol 100g, Oleum menthae (in right amount).
Method for making:
More than seven the flavor, get Radix Rehmanniae Preparata and be ground into fine powder, sieve; All the other Six-element medical materials decoct with water twice, add for the first time 8 times of water gagings, add 6 times of water gagings, each 2 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), adds 7/10 Radix Rehmanniae Preparata fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, adipic acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the adipic acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Radix Rehmanniae Preparata fine powder, spray into Oleum menthae, add polyethylene glycol 6000, Macrogol 4000, sodium lauryl sulphate, Pulvis Talci, the mannitol mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 21
Prescription:
Crude drug: Actinolitum 1392g, Cortex Cinnamomi 754g, Fructus Cnidii 882g, Semen Cuscutae 578g, Semen Euryales 480g, Radix Rehmanniae Preparata 1160g, Fructus Foeniculi 754g;
Adjuvant: Oleum menthae (in right amount), citric acid 1200g (in anhydride), sodium bicarbonate 800g, polyethylene glycol 6000 120g.
Method for making:
More than seven the flavor, get Radix Rehmanniae Preparata and be ground into fine powder, sieve; All the other Six-element medical materials decoct with water twice, add for the first time 8 times of water gagings, add 6 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), adds 7/10 Radix Rehmanniae Preparata fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, sodium bicarbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid fine powder that adds, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Radix Rehmanniae Preparata fine powder, spray into Oleum menthae, add polyethylene glycol 6000, mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 22
Prescription:
Crude drug: Actinolitum 1190g, Cortex Cinnamomi 952g, Fructus Cnidii 1166g, Semen Cuscutae 904g, Semen Euryales 593g, Radix Rehmanniae Preparata 600g, Fructus Foeniculi 595g;
Adjuvant: citric acid 700g (in anhydride), fumaric acid 500g, sodium bicarbonate 480g, sodium carbonate 400g, polyethylene glycol 6000 100g, Macrogol 4000 40g.
Method for making:
More than seven the flavor, get Radix Rehmanniae Preparata and be ground into fine powder, sieve; All the other Six-element medical materials decoct with water twice, add for the first time 8 times of water gagings, add 7.5 times of water gagings, each 2.5 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), adds 7/10 Radix Rehmanniae Preparata fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Radix Rehmanniae Preparata fine powder, add polyethylene glycol 6000, the Macrogol 4000 mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 23
Prescription:
Crude drug: Actinolitum 1239g, Cortex Cinnamomi 990g, Fructus Cnidii 1214g, Semen Cuscutae 940g, Semen Euryales 617g, Radix Rehmanniae Preparata 600g, Fructus Foeniculi 400g;
Adjuvant: citric acid 800g (in anhydride), fumaric acid 400g, sodium bicarbonate 400g, sodium carbonate 800g, polyethylene glycol 6000 100g, Macrogol 4000 30g, sodium lauryl sulphate 10g, mannitol 100g, Oleum menthae (in right amount).
Method for making:
More than seven the flavor, get Radix Rehmanniae Preparata and be ground into fine powder, sieve; All the other Six-element medical materials decoct with water twice, add for the first time 8 times of water gagings, add 6 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), adds 7/10 Radix Rehmanniae Preparata fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds potassium bicarbonate and potassium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Radix Rehmanniae Preparata fine powder, spray into Oleum menthae, add polyethylene glycol 6000, Macrogol 4000, sodium lauryl sulphate, the mannitol mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Embodiment 24
Prescription:
Crude drug: Actinolitum 636g, Cortex Cinnamomi 300g, Fructus Cnidii 564g, Semen Cuscutae 1108g, Semen Euryales 1357g, Radix Rehmanniae Preparata 1470g, Fructus Foeniculi 565g;
Adjuvant: citric acid 700g (in anhydride), fumaric acid 300g, sodium bicarbonate 700g, sodium carbonate 300g, polyethylene glycol 6000 100g, Macrogol 4000 30g, sodium lauryl sulphate 10g, Pulvis Talci 10g, mannitol 100g, Oleum menthae (in right amount).
Method for making:
More than seven the flavor, get Radix Rehmanniae Preparata and be ground into fine powder, sieve; All the other Six-element medical materials decoct with water twice, add for the first time 8 times of water gagings, add 7 times of water gagings, each 3 hours for the second time, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), adds 7/10 Radix Rehmanniae Preparata fine powder, mixing, 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be standby.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is made granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Radix Rehmanniae Preparata fine powder, spray into Oleum menthae, add polyethylene glycol 6000, Macrogol 4000, sodium lauryl sulphate, Pulvis Talci, the mannitol mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly.
Claims (4)
1. the foot-bath effervescent tablet of a warming and invigorating kidney deficiency, this foot-bath effervescent tablet mainly is made up of active ingredient, effervescent excipient and binding agent, it is characterized in that described active ingredient is to be made up of 10%～40% the Radix Rehmanniae Preparata powder and the water extract of following crude drug by the percentage by weight of crude drug:
Actinolitum 8%-30%, Cortex Cinnamomi 5%-20%, Fructus Cnidii 8%-30%, Semen Cuscutae 8%-30%, Semen Euryales 8%-30%, Fructus Foeniculi 5%-20%.
2. the foot-bath effervescent tablet of a kind of warming and invigorating kidney deficiency according to claim 1 is characterized in that, described active ingredient is to be made up of 16.08%～32.50% the Radix Rehmanniae Preparata powder and the water extract of following crude drug by the percentage by weight of crude drug:
Actinolitum 14.05%～25.00%, Cortex Cinnamomi 8.04%～16.25%, Fructus Cnidii 12.46%～24.50%, Semen Cuscutae 12.46%～24.50%, Semen Euryales 12.46%～24.50%, Fructus Foeniculi 8.04%～16.25%.
3. the foot-bath effervescent tablet of a kind of warming and invigorating kidney deficiency according to claim 2, it is characterized in that, described active ingredient is to be made up of 19.6% the Radix Rehmanniae Preparata powder and the water extract of following crude drug by the percentage by weight of crude drug: Actinolitum 16.3%, Cortex Cinnamomi 9.7%, Fructus Cnidii 14.9%, Semen Cuscutae 14.9%, Semen Euryales 14.9%, Fructus Foeniculi 9.7%.
4. according to the foot-bath effervescent tablet of claim 1,2 or 3 described a kind of warming and invigorating kidney deficiencies, it is characterized in that described water extract is prepared by following method:
Get Actinolitum, Cortex Cinnamomi, Fructus Cnidii, Semen Cuscutae, Semen Euryales and Fructus Foeniculi by proportioning, add 6-10 times of water gaging earlier, decocted 1.5-3 hour, filter; Filtering residue adds 6-10 times of water gaging again, decocts 1.5-3 hour, filters; Merge filtrate twice, concentrate, be drying to obtain.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101797893A CN101850025B (en) | 2010-05-17 | 2010-05-17 | Foot bathing effervescent tablets for warming and invigorating kidney deficiency |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101797893A CN101850025B (en) | 2010-05-17 | 2010-05-17 | Foot bathing effervescent tablets for warming and invigorating kidney deficiency |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101850025A CN101850025A (en) | 2010-10-06 |
| CN101850025B true CN101850025B (en) | 2011-10-05 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2010101797893A Expired - Fee Related CN101850025B (en) | 2010-05-17 | 2010-05-17 | Foot bathing effervescent tablets for warming and invigorating kidney deficiency |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102008584B (en) * | 2010-12-14 | 2011-11-30 | 句容市边城卫生院 | Drug for treating cold-aggregating qi-stasis dysmenorrhea |
| CN103272003B (en) * | 2013-06-04 | 2015-05-13 | 张勇 | Warming, freckle removing and foot soaking medicine |
| CN105616287A (en) * | 2016-01-20 | 2016-06-01 | 广州丹奇日用化工厂有限公司 | Effervescent tablet containing volatile oil |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1615998A (en) * | 2004-09-27 | 2005-05-18 | 俞锋 | Kidney tonifying capsule and its preparing method |
| CN1947684A (en) * | 2006-10-20 | 2007-04-18 | 温州医学院 | Traditional Chinese medicine effervescence tablets for feet-washing, and its prepn. method |
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2010
- 2010-05-17 CN CN2010101797893A patent/CN101850025B/en not_active Expired - Fee Related
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| Publication number | Publication date |
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| CN101850025A (en) | 2010-10-06 |
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