CN101829252B - Footbath effervescent tablet for improving sub-health - Google Patents
Footbath effervescent tablet for improving sub-health Download PDFInfo
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- CN101829252B CN101829252B CN2010101797817A CN201010179781A CN101829252B CN 101829252 B CN101829252 B CN 101829252B CN 2010101797817 A CN2010101797817 A CN 2010101797817A CN 201010179781 A CN201010179781 A CN 201010179781A CN 101829252 B CN101829252 B CN 101829252B
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Abstract
The invention relates to a traditional Chinese medicine compound preparation, in particular to a footbath effervescent tablet for improving sub-health. The footbath effervescent tablet is mainly prepared from active ingredients, an effervescence excipient, and an adhesive. The compound preparation is characterized in that the active ingredients consists of the following raw materials in percentage by weight: 6%-25% of Szechwan lovage rhizome powder and water extracts of the following raw materials of 10%-30% of pilose asiabell root, 12%-35% of tuckahoe, 6%-25% of largehead atractylodes rhizome, 6%-20% of orange peel, 12%-35% of astragalus root, and 3%-15% of glass-leaved sweetflag. The invention can adjust the viscera function, and improve the sub-health.
Description
Invention field
The present invention relates to medicinal preparation, be specifically related to a kind of compound Chinese medicinal preparation.
Technical background
Subhealth state has been to endanger the No.1 stealthy killer of health of people now.According to statistics, there is 60～70% crowd to be in sub-health state in China.At present, not clear and definite fully as yet for the mechanism of sub-health state, modern medicine does not also have the better prevention way to it.Yet motherland's medical science has remarkable advantages aspect the preventing and treating of sub-health state.Because the incidence rate of sub-health state is very high, this just requires must be popular to its means of prevention and method, to satisfy numerous sub-health population demand.Therefore, seek that a kind of can to bring into play the popular again subhealth state method of preventing and treating of tcm characteristic be desirability.
It is in the majority with oral formulations to have the Chinese medicine that improves subhealth state now, and first pass effect is difficult to avoid, and takes bigger side effect for a long time.The tradition traditional Chinese medical science thinks that human five internal organs's six internal organs all have corresponding echo area on foot, and foot is the terminal of 6 meridians of human body, and more than 60 acupuncture point arranged.Therefore, adopt dipping pedicure a kind of desirable selection of can yet be regarded as.When bathing foot, both can make the effective ingredient Transdermal absorption of medicine, but the holographic echo area in effective stimulus vola again, thus regulate function, strengthening vital QI to eliminate pathogenic factors reaches the effect of building body.The product of at present commercially available dipping pedicure is powder and packed dosage form; Form by direct pulverizing of medicine; The effective ingredient stripping of medicine is slow, and the especially fully stripping of effective ingredient of medicine under the acceptable water temperature of human body has obviously reduced bioavailability.
For the abundant technical problem of stripping of the effective ingredient that solves medicine under the acceptable water temperature of human body; Publication number is that the patent application of CN 1947684A has disclosed a kind of " effervescence tablets for feet-washing "; This effervescence tablets for feet-washing comprises the organic acid that accounts for gross mass 20%-40%, the sodium bicarbonate of 20-40%, the surfactant of 0.2-2.0% and the lubricant of 0.1%-5%; It is characterized in that: described Chinese medicine effervescence tablets for feet-washing also contains the Oleum Curcumae that accounts for gross mass 1-10%, 3-10% Radix Sophorae Flavescentis, 5-30% sodium chloride and an amount of binding agent.Raw material of Chinese medicine in the said scheme of above-mentioned patent application is Oleum Curcumae and Radix Sophorae Flavescentis; Description by its description can be known; Described Radix Sophorae Flavescentis crude drug just just has been used as medicine through pulverizing; Although therefore processed effervescent tablet, dissolve rapidly in the time of making tablet meet water, the effective ingredient under the acceptable water temperature of human body in the Radix Sophorae Flavescentis material powder is fully stripping rapidly still.In addition, limit, report that from its description and effect experiment visible described effervescence tablets for feet-washing is through the antibacterial anti-inflammatory anti-itch of realizing although the theme of above-mentioned patent application scheme does not carry out purposes.
Summary of the invention
In view of there is above-mentioned deficiency in prior art, technical problem to be solved by this invention provides a kind of foot-bath effervescent tablet that improves subhealth state.
The technical scheme that the present invention addresses the above problem is described below:
A kind of foot-bath effervescent tablet that improves subhealth state; This foot-bath effervescent tablet mainly is made up of active ingredient, effervescent excipient and binding agent; It is characterized in that described active ingredient is to form by the water extract of the Rhizoma Chuanxiong power of the percentage by weight 6%～25% of crude drug and following crude drug:
Radix Codonopsis 10%～30%, Poria 12%～35%, the Rhizoma Atractylodis Macrocephalae 6%～25%, Pericarpium Citri Reticulatae 6%～20%, the Radix Astragali 12%～35%, Rhizoma Acori Graminei 3%～15%.
Foot-bath effervescent tablet of the present invention; Wherein said active ingredient better is to be made up of 10.75%～20.25% the Rhizoma Chuanxiong power and the water extract of following crude drug by the percentage by weight of crude drug: Radix Codonopsis 15.00%～25.00%; Poria 17.75%～29.25%, the Rhizoma Atractylodis Macrocephalae 10.75%～20.25%, Pericarpium Citri Reticulatae 9.50%～16.50%; The Radix Astragali 18.50%～29.50%, Rhizoma Acori Graminei 6.00%～12.00%; The percentage by weight of preferably pressing crude drug is made up of 12.5% the Rhizoma Chuanxiong power and the water extract of following crude drug: Radix Codonopsis 16.8%, Poria 19.8%, the Rhizoma Atractylodis Macrocephalae 12.5%, Pericarpium Citri Reticulatae 10.8%, the Radix Astragali 20.5%, Rhizoma Acori Graminei 7.1%.
Foot-bath effervescent tablet of the present invention; Wherein said water extract can adopt this area water extracting method commonly used to prepare; The method that the present invention recommends is described below: get Radix Codonopsis, Poria, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, the Radix Astragali and Rhizoma Acori Graminei by proportioning; Add 6-10 times of water gaging, decocted 1.5-3 hour, filter; Filtering residue adds 6-10 times of water gaging, decocts 1.5-3 hour, filters; Merge filtrating twice, concentrate, be drying to obtain.
Effervescent excipient in the foot-bath effervescent tablet of the present invention is acid source and alkali source commonly used, and wherein, described acid source is one or more in citric acid, tartaric acid, fumaric acid, adipic acid and the malic acid; Described alkali source is one or more in sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate and the calcium carbonate.Above-mentioned acid source is the best with citric acid or tartaric acid.Above-mentioned alkali source is good with sodium carbonate, sodium bicarbonate or potassium bicarbonate.
Foot-bath effervescent tablet of the present invention, wherein said binding agent are a kind of or two or more in PEG4000～6000 of isopropyl alcohol, alcoholic solution and low relative molecular mass of hypromellose aqueous solution, PVP ethanol (water) solution, olefin(e) acid resin aqueous solution, starch slurry, ethanol, syrup, isopropyl alcohol, PEG (12000～20000).
Foot-bath effervescent tablet of the present invention; Can also add the lubricant of being convenient to granulate according to the production technology needs, said lubricant is a kind of or two or more in Macrogol 4000, polyethylene glycol 6000, sodium lauryl sulphate, Stepanol MG, L-leucine, sodium benzoate, enuatrol, sodium chloride, sodium acetate, boric acid, magnesium stearate, Pulvis Talci, micropowder silica gel, sucrose fatty acid ester and the sodium stearyl fumarate.
Foot-bath effervescent tablet of the present invention can also add other adjuvant commonly used; As; Filler, foaming agent are or/and correctives, and wherein, described filler is one or more in starch, microcrystalline Cellulose, dextrin lactose, mannitol, sucrose and the glucose; Described foaming agent is a kind of or two or more in tween 80, sodium lauryl sulphate and the hexadecanol; Described correctives is one or more in Oleum menthae, Oleum Rosae Rugosae, Fructus Citri Limoniae oil, apple essence, flavoring orange essence, Oleum Anisi Stellati and the flavoring banana essence.
Foot-bath effervescent tablet of the present invention is a kind of pharmaceutical preparation commonly used, and the selection of its adjuvant and method for preparing can be implemented with reference to " the technical study overview of Chinese medicine effervescent tablet " literary composition of " traditional medicine " 2008 the 17th volumes the 10th phase the 72nd page of publication.
Theory of Chinese medical science thinks that healthy subjects should be the organism of balance coordination, and " element is asked the vital QI of the body connecting with natural QI opinion " has literary composition: " YIN and YANG in a relative equilibrium, life activities being normally maintained.Dissociation of YIN from YANG, exhaustion of vital essence.Here " putting down " all refers to balance with " secret ", is that guiding principle points out that balance is " spirit is controlled " with negative and positive, and be promptly able-bodied basic." element is asked the regulating menstruation opinion " also defines normal person: " negative and positive are even flat, and to fill its shape, nine wait as if one, and life is said normal person." normal body through self regulation, keeps the relative equilibrium of human body yang blood and qi, ascending, descending, exiting and entering in certain limit, the inclined to one side mistake in the certain limit occurs, do not become the state of remarkable disease to be subhealth state.Active ingredient of the present invention is processed by Radix Codonopsis, Poria, the Rhizoma Atractylodis Macrocephalae, Rhizoma Chuanxiong, Pericarpium Citri Reticulatae, the Radix Astragali, Rhizoma Acori Graminei, and wherein, monarch drug is Radix Codonopsis, the Radix Astragali, Poria, the Rhizoma Atractylodis Macrocephalae, has the merit that consolidating superficial resistance, spleen invigorating mind calming are defended in invigorating the spleen and replenishing QI, benefit; Ministerial drug is Pericarpium Citri Reticulatae, Rhizoma Chuanxiong, ability regulating qi-flowing for strengthening spleen, blood-activating and qi-promoting; Adjuvant drug is a Rhizoma Acori Graminei, has the merit of calming the nerves.Above-mentioned seven flavor compatibilities reach benefiting vital QI and blood, improve fatigue, effects such as enhances human body resistance.
Foot-bath effervescent tablet of the present invention is put into water, under the effect of gas-producing disintegrant, produces great amount of bubbles (carbon dioxide) at once tablet is rolled up and down in water; Quicken its disintegrate and thawing; And then make the rapid stripping of active ingredient in the tablet, when bathing foot, but the effective ingredient Transdermal absorption; Regulate function, and then realize improving the purpose of subhealth state.
Following clinical experiment further specifies the advantage and the technique effect that can reach of improving the foot-bath effervescent tablet of subhealth state according to the invention.
Clinical experiment
One, physical data
All cases are the patient that subhealth symptom is arranged, male's 38 examples, age 30-50 year; Women's 22 examples, 25～45 years old age.Be divided into foot bath group 30 examples (male 19 examples, women 11 examples) at random; Blank group 30 examples (male 19 examples, women 11 examples).Treat preceding two groups of patients' sex, age, subhealth symptom integration there are no significant difference (P＞0.05), have comparability.
Two, include standard in
Show effect lastingly or repeatedly, and continue to have the case more than 6 months.Meet the case of the standard of including in, as suffer from various organic diseases and then do not list this therapeutic domain in.
Three, method
Bathe the foot group: the hot water of 10 of the foot-bath effervescent tablets of embodiment 1 being put into 4 liters 38～40 ℃ is bathed foot, and each 30 minutes, once a day, continuous 2 weeks.
Blank control group: bathe foot with 4 liters 38～40 ℃ clear water, each 30 minutes, once a day, continuous 2 weeks.
Four, observation of curative effect
The clinical symptoms standards of grading: with fatigue, insomnia, memory, mood, extremities aching pain five aspects are that leading indicator is marked, each index is divided into 4 grades by degrees of symptoms, is respectively non-evident sympton, mild, moderate symptom, severe symptom.Scoring rule is non-evident sympton 0 minute, mild 1 minute, moderate symptom 2 minutes, severe symptom 3 minutes.Evaluation time is respectively before the treatment beginning and after the treatment end.
Concrete standards of grading are following:
Tired: non fatigue feeling is counted 0 fen, and idol has feeling of fatigue to count 1 fen, the time have feeling of fatigue to count 2 fens, often have feeling of fatigue to count 3 fens;
Insomnia: do not have insomnia and counts 0 fen, idol having insomnia to count 1 fen, the time have insomnia to count 2 fens, often having insomnia to count 3 fens;
Memory: memoryless power weakens counts 0 fen, and idol has memory to weaken to count 1 fen, and time has memory to weaken to count 2 fens, often have memory to weaken and count 3 fens;
Mood: happyly count 0 fen, idol is uncomfortable in the vein, and unhappiness is counted 1 fen, the time uncomfortable in the vein, unhappiness is counted 2 fens, often uncomfortable in the vein, unhappiness is counted 3 fens;
Extremities aching pain: no extremities aching pain sense is counted 0 fen, the idol have the extremities aching pain sense to count 1 fen, the time have the extremities aching pain sense to count 2 fens, often have the extremities aching pain sense to count 3 fens;
Efficacy assessment standard: this standard reference " new Chinese medicine clinical research guideline " is formulated, score value * 100% before clinical symptoms integrated value improvement rate=(symptom integral value before the treatment-treatment back symptom integral value)/treatment.
Efficacy assessment standard:
Produce effects: symptom integral value improvement rate >=70%;
Effectively: symptom integral value improvement rate >=50%;
Invalid: symptom does not see that obvious improvement or counter sees deterioration, symptom integral value improvement rate＜50%.
Statistical procedures: total data adopts SPSS 13.0 statistics softwares to carry out statistical analysis, and measurement data is with mean ± standard deviation (x ± s) expression.Symptom score more all adopted the t check before and after two groups of experimenters treated, and two groups of experimenter's clinical efficacies relatively adopt X
2Check.
Four. result of the test:
The clinical symptoms integration is relatively seen table 1 before and after foot bath group and the blank control group; Curative effect is relatively seen table 2; Table 3 is relatively seen in the improvement of cardinal symptom sign.Can know from table 2, bathe foot group effect apparently higher than blank control group.N in table 1～table 3 representes number.
Clinical symptoms was marked relatively (x ± s divides) before and after table 1 a liang group was bathed foot
| Group | n | Before bathing foot | After bathing foot |
| Bathe the foot group | 30 | 10.79±2.69 | 5.06±2.15a?b |
| Blank control group | 30 | 10.43±2.15 | 9.89±2.17 |
Foot bath is preceding compares with bath foot back: Pa＜0.05; Bathe foot group bath foot back and bathe sufficient back relatively: Pb＜0.05 with blank control group
Table 2 liang group curative effect relatively
Table 3 treatment group and matched group cardinal symptom sign are improved relatively
Foot bath is preceding compares with bath foot back: Pa＜0.05; Bathe foot group bath foot back and bathe sufficient back relatively: Pb＜0.05 with blank control group
The specific embodiment
Embodiment 1
Prescription:
Crude drug: Radix Codonopsis 783g, Poria 923g, Rhizoma Atractylodis Macrocephalae 583g, Rhizoma Chuanxiong 583g, Pericarpium Citri Reticulatae 503g, Radix Astragali 955g, Rhizoma Acori Graminei 331g;
Adjuvant: Oleum menthae (in right amount), Fructus Citri Limoniae 600g (in anhydride), sodium bicarbonate 780g, polyethylene glycol 6000 120g.
Method for making:
More than seven the flavor crude drug, get Rhizoma Chuanxiong power and be broken into fine powder, sieve; All the other Six-element medical material decocte with water secondaries add 8 times of water gagings for the first time, add 6 times of water gagings for the second time; Each 3 hours, merge the secondary decocting liquid, filter; Filtrating is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), adds 7/10 Rhizoma Chuanxiong fine powder, mixing; 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, sodium bicarbonate are dry respectively, are ground into fine powder, sieve, and be subsequent use.Above-mentioned extract powder is divided into two parts, a citric acid fine powder that adds, mixing is processed granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate fine powder, and mixing is processed granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Rhizoma Chuanxiong fine powder, spray into Oleum menthae, add polyethylene glycol 6000, mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly gets.
Embodiment 2
Prescription:
Crude drug: Radix Codonopsis 466g, Poria 665g, Rhizoma Atractylodis Macrocephalae 580g, Rhizoma Chuanxiong 758g, Pericarpium Citri Reticulatae 749g, Radix Astragali 1105g, Rhizoma Acori Graminei 337g;
Adjuvant: citric acid 300g (in anhydride), fumaric acid 300g, sodium bicarbonate 480g, sodium carbonate 300g, polyethylene glycol 6000 100g, Macrogol 4000 40g.
Method for making:
More than seven the flavor crude drug, get Rhizoma Chuanxiong power and be broken into fine powder, sieve; Six-element medical material decocte with water secondaries such as all the other Rhizoma Acori Graminei add 10 times of water gagings for the first time, add 10 times of water gagings for the second time; Each 2 hours, merge the secondary decocting liquid, filter; Filtrating is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), adds 7/10 Rhizoma Chuanxiong fine powder, mixing; 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be subsequent use.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is processed granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is processed granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Rhizoma Chuanxiong fine powder, add polyethylene glycol 6000, the Macrogol 4000 mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly gets.
Embodiment 3
Prescription:
Crude drug: Radix Codonopsis 747g, Poria 559g, Rhizoma Atractylodis Macrocephalae 402g, Rhizoma Chuanxiong 579g, Pericarpium Citri Reticulatae 617g, Radix Astragali 1308g, Rhizoma Acori Graminei 448g;
Adjuvant: citric acid 300g (in anhydride), fumaric acid 300g, sodium bicarbonate 480g, sodium carbonate 300g, Polyethylene Glycol 5000 100g, Macrogol 4000 30g, sodium lauryl sulphate 10g, mannitol 100g, Oleum menthae, Oleum Rosae Rugosae (in right amount).
Method for making:
More than seven the flavor crude drug, get Rhizoma Chuanxiong power and be broken into fine powder, sieve; Six-element medical material decocte with water secondaries such as all the other Rhizoma Acori Graminei add 10 times of water gagings for the first time, add 10 times of water gagings for the second time; Each 2 hours, merge the secondary decocting liquid, filter; Filtrating is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), adds 7/10 Rhizoma Chuanxiong fine powder, mixing; 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be subsequent use.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is processed granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is processed granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Rhizoma Chuanxiong fine powder, spray into Oleum menthae, add Polyethylene Glycol 5000, Macrogol 4000, sodium lauryl sulphate, the mannitol mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly gets.
Embodiment 4
Prescription:
Crude drug: Radix Codonopsis 938g, Poria 882g, Rhizoma Atractylodis Macrocephalae 280g, Rhizoma Chuanxiong 403g, Pericarpium Citri Reticulatae 488g, Radix Astragali 1107g, Rhizoma Acori Graminei 562g;
Adjuvant: citric acid 300g (in anhydride), fumaric acid 300g, sodium bicarbonate 480g, sodium carbonate 300g, polyethylene glycol 6000 100g, Macrogol 4000 30g, sodium lauryl sulphate 10g, Pulvis Talci 10g, mannitol 100g, Oleum menthae (in right amount).
Method for making:
More than seven the flavor crude drug, get Rhizoma Chuanxiong power and be broken into fine powder, sieve; Six-element medical material decocte with water secondaries such as all the other Rhizoma Acori Graminei add 8 times of water gagings for the first time, add 8 times of water gagings for the second time; Each 3 hours, merge the secondary decocting liquid, filter; Filtrating is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), adds 9/10 Rhizoma Chuanxiong fine powder, mixing; 90 ℃ of dryings are ground into fine powder, sieve.Citric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be subsequent use.Above-mentioned extract powder is divided into two parts, a citric acid fine powder that adds, mixing is processed granule, 90 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is processed granule, 90 ℃ of dryings, No. two sieve granulate; Get residue Rhizoma Chuanxiong fine powder, spray into Oleum menthae, add polyethylene glycol 6000, Macrogol 4000, sodium lauryl sulphate, Pulvis Talci, the mannitol mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly gets.
Embodiment 5
Prescription:
Crude drug: Radix Codonopsis 1093g, Poria 1066g, Rhizoma Atractylodis Macrocephalae 565g, Rhizoma Chuanxiong 280g, Pericarpium Citri Reticulatae 346g, Radix Astragali 874g, Rhizoma Acori Graminei 436g;
Adjuvant: Oleum Rosae Rugosae (in right amount), citric acid 600g (in anhydride), potassium bicarbonate 1200g, Polyethylene Glycol 5000120g.
Method for making:
More than seven the flavor crude drug, get Rhizoma Chuanxiong power and be broken into fine powder, sieve; Six-element medical material decocte with water secondaries such as all the other Rhizoma Acori Graminei add 9 times of water gagings for the first time, add 6 times of water gagings for the second time; Each 3 hours, merge the secondary decocting liquid, filter; Filtrating is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), adds 9/10 Rhizoma Chuanxiong fine powder, mixing; 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, potassium bicarbonate are dry respectively, are ground into fine powder, sieve, and be subsequent use.Above-mentioned extract powder is divided into two parts, a citric acid fine powder that adds, mixing is processed granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds the potassium bicarbonate fine powder, and mixing is processed granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Rhizoma Chuanxiong fine powder, spray into Oleum Rosae Rugosae, add Polyethylene Glycol 5000, mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly gets.
Embodiment 6
Prescription:
Crude drug: Radix Codonopsis 888g, Poria 1244g, Rhizoma Atractylodis Macrocephalae 720g, Rhizoma Chuanxiong 550g, Pericarpium Citri Reticulatae 280g, Radix Astragali 658g, Rhizoma Acori Graminei 320g;
Adjuvant: citric acid 300g (in anhydride), fumaric acid 300g, sodium bicarbonate 600g, sodium carbonate 600g, polyethylene glycol 6000 100g, Macrogol 4000 40g.
Method for making:
More than seven the flavor crude drug, get Rhizoma Chuanxiong power and be broken into fine powder, sieve; Six-element medical material decocte with water secondaries such as all the other Rhizoma Acori Graminei add 10 times of water gagings for the first time, add 10 times of water gagings for the second time; Each 1.5 hours, merge the secondary decocting liquid, filter; Filtrating is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), adds 9/10 Rhizoma Chuanxiong fine powder, mixing; 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be subsequent use.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is processed granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is processed granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Rhizoma Chuanxiong fine powder, add polyethylene glycol 6000, the Macrogol 4000 mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly gets.
Embodiment 7
Prescription:
Crude drug: Radix Codonopsis 714g, Poria 1045g, Rhizoma Atractylodis Macrocephalae 893g, Rhizoma Chuanxiong 723g, Pericarpium Citri Reticulatae 464g, Radix Astragali 606g, Rhizoma Acori Graminei 215g;
Adjuvant: citric acid 300g (in anhydride), fumaric acid 300g, sodium bicarbonate 580g, sodium carbonate 400g, polyethylene glycol 6000 100g, Macrogol 4000 30g, sodium lauryl sulphate 10g, mannitol 100g, Oleum menthae (in right amount).
Method for making:
More than seven the flavor crude drug, get Rhizoma Chuanxiong power and be broken into fine powder, sieve; Six-element medical material decocte with water secondaries such as all the other Rhizoma Acori Graminei add 9 times of water gagings for the first time, add 8 times of water gagings for the second time; Each 3 hours, merge the secondary decocting liquid, filter; Filtrating is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), adds 7/10 Rhizoma Chuanxiong fine powder, mixing; 90 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be subsequent use.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is processed granule, 90 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is processed granule, 90 ℃ of dryings, No. two sieve granulate; Get residue Rhizoma Chuanxiong fine powder, spray into Oleum menthae, add polyethylene glycol 6000, Macrogol 4000, sodium lauryl sulphate, the mannitol mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly gets.
Embodiment 8
Prescription:
Crude drug: Radix Codonopsis 546g, Poria 855g, Rhizoma Atractylodis Macrocephalae 737g, Rhizoma Chuanxiong 909g, Pericarpium Citri Reticulatae 600g, Radix Astragali 873g, Rhizoma Acori Graminei 140g;
Adjuvant: citric acid 400g (in anhydride), fumaric acid 300g, sodium bicarbonate 580g, sodium carbonate 400g, polyethylene glycol 6000 100g, Macrogol 4000 30g, sodium lauryl sulphate 10g, Pulvis Talci 10g, mannitol 100g, Oleum menthae (in right amount).
Method for making:
More than seven the flavor crude drug, get Rhizoma Chuanxiong power and be broken into fine powder, sieve; Six-element medical material decocte with water secondaries such as all the other Rhizoma Acori Graminei add 8 times of water gagings for the first time, add 9 times of water gagings for the second time; Each 3 hours, merge the secondary decocting liquid, filter; Filtrating is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), adds 7/10 Rhizoma Chuanxiong fine powder, mixing; 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be subsequent use.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is processed granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is processed granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Rhizoma Chuanxiong fine powder, spray into Oleum menthae, add polyethylene glycol 6000, Macrogol 4000, sodium lauryl sulphate, Pulvis Talci, the mannitol mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly gets.
Embodiment 9
Prescription:
Crude drug: Radix Codonopsis 537g, Poria 841g, Rhizoma Atractylodis Macrocephalae 724g, Rhizoma Chuanxiong 894g, Pericarpium Citri Reticulatae 590g, Radix Astragali 859g, Rhizoma Acori Graminei 215g;
Adjuvant: Oleum menthae (in right amount), citric acid 1200g (in anhydride), sodium bicarbonate 600g, polyethylene glycol 6000 120g.
Method for making:
More than seven the flavor crude drug, get Rhizoma Chuanxiong power and be broken into fine powder, sieve; Six-element medical material decocte with water secondaries such as all the other Rhizoma Acori Graminei add 10 times of water gagings for the first time, add 10 times of water gagings for the second time; Each 2 hours, merge the secondary decocting liquid, filter; Filtrating is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), adds 7/10 Rhizoma Chuanxiong fine powder, mixing; 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, sodium bicarbonate are dry respectively, are ground into fine powder, sieve, and be subsequent use.Above-mentioned extract powder is divided into two parts, a citric acid fine powder that adds, mixing is processed granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate fine powder, and mixing is processed granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Rhizoma Chuanxiong fine powder, spray into Oleum menthae, add polyethylene glycol 6000, mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly gets.
Embodiment 10
Prescription:
Crude drug: Radix Codonopsis 550g, Poria 651g, Rhizoma Atractylodis Macrocephalae 570g, Rhizoma Chuanxiong 743g, Pericarpium Citri Reticulatae 734g, Radix Astragali 1082g, Rhizoma Acori Graminei 330g;
Adjuvant: citric acid 600g (in anhydride) fumaric acid 600g, sodium bicarbonate 300g, sodium carbonate 300g, polyethylene glycol 6000 100g, Macrogol 4000 40g.
Method for making:
More than seven the flavor crude drug, get Rhizoma Chuanxiong power and be broken into fine powder, sieve; Six-element medical material decocte with water secondaries such as all the other Rhizoma Acori Graminei add 8.5 times of water gagings for the first time, add 6.5 times of water gagings for the second time; Each 3 hours, merge the secondary decocting liquid, filter; Filtrating is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), adds 7/10 Rhizoma Chuanxiong fine powder, mixing; 85 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be subsequent use.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is processed granule, 85 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is processed granule, 85 ℃ of dryings, No. two sieve granulate; Get residue Rhizoma Chuanxiong fine powder, add polyethylene glycol 6000, the Macrogol 4000 mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly gets.
Embodiment 11
Prescription:
Crude drug: Radix Codonopsis 730g, Poria 649g, Rhizoma Atractylodis Macrocephalae 393g, Rhizoma Chuanxiong 567g, Pericarpium Citri Reticulatae 603g, Radix Astragali 1279g, Rhizoma Acori Graminei 439g;
Adjuvant: citric acid 400g (in anhydride), fumaric acid 800g, sodium bicarbonate 200g, sodium carbonate 400g, polyethylene glycol 6000 100g, Macrogol 4000 30g, sodium lauryl sulphate 10g, mannitol 100g, Oleum menthae (in right amount).
Method for making:
More than seven the flavor crude drug, get Rhizoma Chuanxiong power and be broken into fine powder, sieve; Six-element medical material decocte with water secondaries such as all the other Rhizoma Acori Graminei add 8 times of water gagings for the first time, add 6 times of water gagings for the second time; Each 3 hours, merge the secondary decocting liquid, filter; Filtrating is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), adds 7/10 Rhizoma Chuanxiong fine powder, mixing; 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be subsequent use.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is processed granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is processed granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Rhizoma Chuanxiong fine powder, spray into Oleum menthae, add polyethylene glycol 6000, Macrogol 4000, sodium lauryl sulphate, the mannitol mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly gets.
Embodiment 12
Prescription:
Crude drug: Radix Codonopsis 914g, Poria 859g, Rhizoma Atractylodis Macrocephalae 393g, Rhizoma Chuanxiong 393g, Pericarpium Citri Reticulatae 475g, Radix Astragali 1078g, Rhizoma Acori Graminei 548g;
Adjuvant: citric acid 900g (in anhydride), fumaric acid 300g, sodium bicarbonate 100g, sodium carbonate 500g, polyethylene glycol 6000 100g, Macrogol 4000 30g, sodium lauryl sulphate 10g, Pulvis Talci 10g, mannitol 100g Oleum menthae (in right amount).
Method for making:
More than seven the flavor crude drug, get Rhizoma Chuanxiong power and be broken into fine powder, sieve; Six-element medical material decocte with water secondaries such as all the other Rhizoma Acori Graminei add 7 times of water gagings for the first time, add 7 times of water gagings for the second time; Each 3 hours, merge the secondary decocting liquid, filter; Filtrating is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), adds 7/10 Rhizoma Chuanxiong fine powder, mixing; 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be subsequent use.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is processed granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is processed granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Rhizoma Chuanxiong fine powder, spray into Oleum menthae, add polyethylene glycol 6000, Macrogol 4000, sodium lauryl sulphate, Pulvis Talci, the mannitol mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly gets.
Embodiment 13
Prescription:
Crude drug: Radix Codonopsis 1067g, Poria 1040g, Rhizoma Atractylodis Macrocephalae 552g, Rhizoma Chuanxiong 382g, Pericarpium Citri Reticulatae 338g, Radix Astragali 854g, Rhizoma Acori Graminei 427g;
Adjuvant: Oleum menthae (in right amount), citric acid 900g (in anhydride), sodium bicarbonate 900g, polyethylene glycol 6000 120g.
Method for making:
More than seven the flavor crude drug, get Rhizoma Chuanxiong power and be broken into fine powder, sieve; Six-element medical material decocte with water secondaries such as all the other Rhizoma Acori Graminei add 8 times of water gagings for the first time, add 6 times of water gagings for the second time; Each 3 hours, merge the secondary decocting liquid, filter; Filtrating is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), adds 7/10 Rhizoma Chuanxiong fine powder, mixing; 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, sodium bicarbonate are dry respectively, are ground into fine powder, sieve, and be subsequent use.Above-mentioned extract powder is divided into two parts, a citric acid fine powder that adds, mixing is processed granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate fine powder, and mixing is processed granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Rhizoma Chuanxiong fine powder, spray into Oleum menthae, add polyethylene glycol 6000, mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly gets.
Embodiment 14
Prescription:
Crude drug: Radix Codonopsis 878g, Poria 1229g, Rhizoma Atractylodis Macrocephalae 711g, Rhizoma Chuanxiong 544g, Pericarpium Citri Reticulatae 333g, Radix Astragali 649g, Rhizoma Acori Graminei 316g;
Adjuvant: citric acid 450g (in anhydride), fumaric acid 450g, sodium bicarbonate 480g, sodium carbonate 420g, polyethylene glycol 6000 100g, Macrogol 4000 40g.
Method for making:
More than seven the flavor crude drug, get Rhizoma Chuanxiong power and be broken into fine powder, sieve; Six-element medical material decocte with water secondaries such as all the other Rhizoma Acori Graminei add 7 times of water gagings for the first time, add 6 times of water gagings for the second time; Each 3 hours, merge the secondary decocting liquid, filter; Filtrating is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), adds 8/10 Rhizoma Chuanxiong fine powder, mixing; 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be subsequent use.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is processed granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is processed granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Rhizoma Chuanxiong fine powder, add polyethylene glycol 6000, the Macrogol 4000 mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly gets.
Embodiment 15
Prescription:
Crude drug: Radix Codonopsis 705g, Poria 1033g, Rhizoma Atractylodis Macrocephalae 883g, Rhizoma Chuanxiong 715g, Pericarpium Citri Reticulatae 459g, Radix Astragali 653g, Rhizoma Acori Graminei 212g;
Adjuvant: citric acid 600g (in anhydride), fumaric acid 300g, sodium bicarbonate 600g, sodium carbonate 300g, polyethylene glycol 6000 100g, Macrogol 4000 30g, sodium lauryl sulphate 10g, mannitol 100g, Oleum menthae (in right amount).
Method for making:
More than seven the flavor crude drug, get Rhizoma Chuanxiong power and be broken into fine powder, sieve; Six-element medical material decocte with water secondaries such as all the other Rhizoma Acori Graminei add 8 times of water gagings for the first time, add 7 times of water gagings for the second time; Each 3 hours, merge the secondary decocting liquid, filter; Filtrating is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), adds 7/10 Rhizoma Chuanxiong fine powder, mixing; 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be subsequent use.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is processed granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is processed granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Rhizoma Chuanxiong fine powder, spray into Oleum menthae, add polyethylene glycol 6000, Macrogol 4000, sodium lauryl sulphate, the mannitol mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly gets.
Embodiment 16
Prescription:
Crude drug: Radix Codonopsis 718g, Poria 1049g, Rhizoma Atractylodis Macrocephalae 897g, Rhizoma Chuanxiong 726g, Pericarpium Citri Reticulatae 466g, Radix Astragali 664g, Rhizoma Acori Graminei 140g;
Adjuvant: citric acid 500g (in anhydride), fumaric acid 400g, sodium bicarbonate 4000g, sodium carbonate 500g, polyethylene glycol 6000 100g, Macrogol 4000 30g, sodium lauryl sulphate 10g, Pulvis Talci 10g, mannitol 100g, Oleum menthae (in right amount).
Method for making:
More than seven the flavor crude drug, get Rhizoma Chuanxiong power and be broken into fine powder, sieve; Six-element medical material decocte with water secondaries such as all the other Rhizoma Acori Graminei add 10 times of water gagings for the first time, add 6 times of water gagings for the second time; Each 3 hours, merge the secondary decocting liquid, filter; Filtrating is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), adds 7/10 Rhizoma Chuanxiong fine powder, mixing; 70 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be subsequent use.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is processed granule, 70 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is processed granule, 70 ℃ of dryings, No. two sieve granulate; Get residue Rhizoma Chuanxiong fine powder, spray into Oleum menthae, add polyethylene glycol 6000, Macrogol 4000, sodium lauryl sulphate, Pulvis Talci, the mannitol mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly gets.
Embodiment 17
Prescription:
Crude drug: Radix Codonopsis 466g, Poria 855g, Rhizoma Atractylodis Macrocephalae 738g, Rhizoma Chuanxiong 910g, Pericarpium Citri Reticulatae 600g, Radix Astragali 873g, Rhizoma Acori Graminei 218g;
Adjuvant: Oleum menthae (in right amount), citric acid 600g (in anhydride), sodium bicarbonate 1200g, polyethylene glycol 6000 120g.
Method for making:
More than seven the flavor crude drug, get Rhizoma Chuanxiong power and be broken into fine powder, sieve; Six-element medical material decocte with water secondaries such as all the other Rhizoma Acori Graminei add 10 times of water gagings for the first time, add 6 times of water gagings for the second time; Each 3 hours, merge the secondary decocting liquid, filter; Filtrating is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), adds 7/10 Rhizoma Chuanxiong fine powder, mixing; 90 ℃ of dryings are ground into fine powder, sieve.Citric acid, sodium bicarbonate are dry respectively, are ground into fine powder, sieve, and be subsequent use.Above-mentioned extract powder is divided into two parts, a citric acid fine powder that adds, mixing is processed granule, 90 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate fine powder, and mixing is processed granule, 90 ℃ of dryings, No. two sieve granulate; Get residue Rhizoma Chuanxiong fine powder, spray into Oleum menthae, add polyethylene glycol 6000, mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly gets.
Embodiment 18
Prescription:
Crude drug: Radix Codonopsis 563g, Poria 559g, Rhizoma Atractylodis Macrocephalae 582g, Rhizoma Chuanxiong 760g, Pericarpium Citri Reticulatae 751g, Radix Astragali 1107g, Rhizoma Acori Graminei 338g;
Adjuvant: citric acid 300g (in anhydride), fumaric acid 300g, sodium bicarbonate 600g, sodium carbonate 600g, polyethylene glycol 6000 100g, Macrogol 4000 40g.
Method for making:
More than seven the flavor crude drug, get Rhizoma Chuanxiong power and be broken into fine powder, sieve; Six-element medical material decocte with water secondaries such as all the other Rhizoma Acori Graminei add 8 times of water gagings for the first time, add 6 times of water gagings for the second time; Each 3 hours, merge the secondary decocting liquid, filter; Filtrating is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), adds 7/10 Rhizoma Chuanxiong fine powder, mixing; 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be subsequent use.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is processed granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is processed granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Rhizoma Chuanxiong fine powder, add polyethylene glycol 6000, the Macrogol 4000 mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly gets.
Embodiment 19
Prescription:
Crude drug: Radix Codonopsis 750g, Poria 666g, Rhizoma Atractylodis Macrocephalae 280g, Rhizoma Chuanxiong 582g, Pericarpium Citri Reticulatae 619g, Radix Astragali 1313g, Rhizoma Acori Graminei 450g;
Adjuvant: citric acid 100g (in anhydride); Fumaric acid 500g; Sodium bicarbonate 900g; Sodium carbonate 300g; Polyethylene glycol 6000 100g, Macrogol 4000 30g, sodium lauryl sulphate 10g, mannitol 100g, Oleum menthae (in right amount).
Method for making:
More than seven the flavor crude drug, get Rhizoma Chuanxiong power and be broken into fine powder, sieve; Six-element medical material decocte with water secondaries such as all the other Rhizoma Acori Graminei add 8 times of water gagings for the first time, add 10 times of water gagings for the second time; Each 3 hours, merge the secondary decocting liquid, filter; Filtrating is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), adds 7/10 Rhizoma Chuanxiong fine powder, mixing; 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be subsequent use.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is processed granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is processed granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Rhizoma Chuanxiong fine powder, spray into Oleum menthae, add polyethylene glycol 6000, Macrogol 4000, sodium lauryl sulphate, the mannitol mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly gets.
Embodiment 20
Prescription:
Crude drug: Radix Codonopsis 938g, Poria 882g, Rhizoma Atractylodis Macrocephalae 403g, Rhizoma Chuanxiong 280g, Pericarpium Citri Reticulatae 488g, Radix Astragali 1106g, Rhizoma Acori Graminei 563g;
Adjuvant: citric acid 500g (in anhydride), fumaric acid 100g, sodium bicarbonate 200g, sodium carbonate 1000g, polyethylene glycol 6000 100g, Macrogol 4000 30g, sodium lauryl sulphate 10g, Pulvis Talci 10g, mannitol 100g, Oleum menthae (in right amount).
Method for making:
More than seven the flavor crude drug, get Rhizoma Chuanxiong power and be broken into fine powder, sieve; Six-element medical material decocte with water secondaries such as all the other Rhizoma Acori Graminei add 8 times of water gagings for the first time, add 9.5 times of water gagings for the second time; Each 3 hours, merge the secondary decocting liquid, filter; Filtrating is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), adds 8/10 Rhizoma Chuanxiong fine powder, mixing; 90 ℃ of dryings are ground into fine powder, sieve.Citric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be subsequent use.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is processed granule, 90 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is processed granule, 90 ℃ of dryings, No. two sieve granulate; Get residue Rhizoma Chuanxiong fine powder, spray into Oleum menthae, add polyethylene glycol 6000, Macrogol 4000, sodium lauryl sulphate, Pulvis Talci, the mannitol mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly gets.
Embodiment 21
Prescription:
Crude drug: Radix Codonopsis 1080g, Poria 1055g, Rhizoma Atractylodis Macrocephalae 559g, Rhizoma Chuanxiong 388g, Pericarpium Citri Reticulatae 280g, Radix Astragali 865g, Rhizoma Acori Graminei 433g;
Adjuvant: Oleum menthae (in right amount), citric acid 1200g (in anhydride), sodium bicarbonate 800g, polyethylene glycol 6000 120g.
Method for making:
More than seven the flavor crude drug, get Rhizoma Chuanxiong power and be broken into fine powder, sieve; Six-element medical material decocte with water secondaries such as all the other Rhizoma Acori Graminei add 8 times of water gagings for the first time, add 6.5 times of water gagings for the second time; Each 3 hours, merge the secondary decocting liquid, filter; Filtrating is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), adds 7/10 Rhizoma Chuanxiong fine powder, mixing; 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, sodium bicarbonate are dry respectively, are ground into fine powder, sieve, and be subsequent use.Above-mentioned extract powder is divided into two parts, a citric acid fine powder that adds, mixing is processed granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate fine powder, and mixing is processed granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Rhizoma Chuanxiong fine powder, spray into Oleum menthae, add polyethylene glycol 6000, mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly gets.
Embodiment 22
Prescription:
Crude drug: Radix Codonopsis 887g, Poria 1242g, Rhizoma Atractylodis Macrocephalae 719g, Rhizoma Chuanxiong 550g, Pericarpium Citri Reticulatae 337g, Radix Astragali 606g, Rhizoma Acori Graminei 319g;
Adjuvant: citric acid 700g (in anhydride), fumaric acid 500g, sodium bicarbonate 480g, sodium carbonate 400g, polyethylene glycol 6000 100g, Macrogol 4000 40g.
Method for making:
More than seven the flavor crude drug, get Rhizoma Chuanxiong power and be broken into fine powder, sieve; Six-element medical material decocte with water secondaries such as all the other Rhizoma Acori Graminei add 8 times of water gagings for the first time, add 8 times of water gagings for the second time; Each 3 hours, merge the secondary decocting liquid, filter; Filtrating is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), adds 7/10 Rhizoma Chuanxiong fine powder, mixing; 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be subsequent use.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is processed granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is processed granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Rhizoma Chuanxiong fine powder, add polyethylene glycol 6000, the Macrogol 4000 mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly gets.
Embodiment 23
Prescription:
Crude drug: Radix Codonopsis 911g, Poria 1275g, Rhizoma Atractylodis Macrocephalae 738g, Rhizoma Chuanxiong 565g, Pericarpium Citri Reticulatae 346g, Radix Astragali 606g, Rhizoma Acori Graminei 219g;
Adjuvant: citric acid 800g (in anhydride), fumaric acid 400g, sodium bicarbonate 400g, sodium carbonate 800g, polyethylene glycol 6000 100g, Macrogol 4000 30g, sodium lauryl sulphate 10g, mannitol 100g, Oleum menthae (in right amount).
Method for making:
More than seven the flavor crude drug, get Rhizoma Chuanxiong power and be broken into fine powder, sieve; Six-element medical material decocte with water secondaries such as all the other Rhizoma Acori Graminei add 8 times of water gagings for the first time, add 6 times of water gagings for the second time; Each 3 hours, merge the secondary decocting liquid, filter; Filtrating is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), adds 7/10 Rhizoma Chuanxiong fine powder, mixing; 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be subsequent use.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is processed granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is processed granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Rhizoma Chuanxiong fine powder, spray into Oleum menthae, add polyethylene glycol 6000, Macrogol 4000, sodium lauryl sulphate, the mannitol mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly gets.
Embodiment 24
Prescription:
Crude drug: Radix Codonopsis 560g, Poria 1093g, Rhizoma Atractylodis Macrocephalae 934g, Rhizoma Chuanxiong 756g, Pericarpium Citri Reticulatae 486g, Radix Astragali 691g, Rhizoma Acori Graminei 140g;
Adjuvant: citric acid 700g (in anhydride), fumaric acid 300g, sodium bicarbonate 700g, sodium carbonate 300g, polyethylene glycol 6000 100g, Macrogol 4000 30g, sodium lauryl sulphate 10g, Pulvis Talci 10g, mannitol 100g Oleum menthae (in right amount).
Method for making:
More than seven the flavor crude drug, get Rhizoma Chuanxiong power and be broken into fine powder, sieve; Six-element medical material decocte with water secondaries such as all the other Rhizoma Acori Graminei add 8 times of water gagings for the first time, add 9 times of water gagings for the second time; Each 1.5 hours, merge the secondary decocting liquid, filter; Filtrating is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), adds 7/10 Rhizoma Chuanxiong fine powder, mixing; 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be subsequent use.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is processed granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is processed granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Rhizoma Chuanxiong fine powder, spray into Oleum menthae, add polyethylene glycol 6000, Macrogol 4000, sodium lauryl sulphate, Pulvis Talci, the mannitol mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly gets.
Embodiment 25
Prescription:
Crude drug: Radix Codonopsis 466g, Poria 680g, Rhizoma Atractylodis Macrocephalae 775g, Rhizoma Chuanxiong 958g, Pericarpium Citri Reticulatae 632g, Radix Astragali 919g, Rhizoma Acori Graminei 230g;
Adjuvant: Oleum menthae (in right amount), citric acid 600g (in anhydride), sodium bicarbonate 780g, polyethylene glycol 6000 120g.
Method for making:
More than seven the flavor crude drug, get Rhizoma Chuanxiong power and be broken into fine powder, sieve; Six-element medical material decocte with water secondaries such as all the other Rhizoma Acori Graminei add 8 times of water gagings for the first time, add 6 times of water gagings for the second time; Each 3 hours, merge the secondary decocting liquid, filter; Filtrating is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), adds 7/10 Rhizoma Chuanxiong fine powder, mixing; 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, sodium bicarbonate are dry respectively, are ground into fine powder, sieve, and be subsequent use.Above-mentioned extract powder is divided into two parts, a citric acid fine powder that adds, mixing is processed granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate fine powder, and mixing is processed granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Rhizoma Chuanxiong fine powder, spray into Oleum menthae, add polyethylene glycol 6000, mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly gets.
Embodiment 26
Prescription:
Crude drug: Radix Codonopsis 589g, Poria 559g, Rhizoma Atractylodis Macrocephalae 422g, Rhizoma Chuanxiong 795g, Pericarpium Citri Reticulatae 785g, Radix Astragali 1158g, Rhizoma Acori Graminei 352g;
Adjuvant: citric acid 800g (in anhydride), fumaric acid 250g, sodium bicarbonate 580g, sodium carbonate 300g, polyethylene glycol 6000 100g, Macrogol 4000 40g.
Method for making:
More than seven the flavor crude drug, get Rhizoma Chuanxiong power and be broken into fine powder, sieve; Six-element medical material decocte with water secondaries such as all the other Rhizoma Acori Graminei add 9 times of water gagings for the first time, add 9 times of water gagings for the second time; Each 2 hours, merge the secondary decocting liquid, filter; Filtrating is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), adds 7/10 Rhizoma Chuanxiong fine powder, mixing; 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be subsequent use.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is processed granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is processed granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Rhizoma Chuanxiong fine powder, add polyethylene glycol 6000, the Macrogol 4000 mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly gets.
Embodiment 27
Prescription:
Crude drug: Radix Codonopsis 782g, Poria 694g, Rhizoma Atractylodis Macrocephalae 280g, Rhizoma Chuanxiong 420g, Pericarpium Citri Reticulatae 645g, Radix Astragali 1370g, Rhizoma Acori Graminei 469g;
Adjuvant: citric acid 800g (in anhydride), fumaric acid 300g, sodium bicarbonate 780g, sodium carbonate 300g, polyethylene glycol 6000 100g, Macrogol 4000 30g, sodium lauryl sulphate 10g, mannitol 100g, Oleum menthae (in right amount).
Method for making:
More than seven the flavor crude drug, get Rhizoma Chuanxiong power and be broken into fine powder, sieve; Six-element medical material decocte with water secondaries such as all the other Rhizoma Acori Graminei add 8 times of water gagings for the first time, add 6 times of water gagings for the second time; Each 3 hours, merge the secondary decocting liquid, filter; Filtrating is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), adds 7/10 Rhizoma Chuanxiong fine powder, mixing; 80 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be subsequent use.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is processed granule, 80 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is processed granule, 80 ℃ of dryings, No. two sieve granulate; Get residue Rhizoma Chuanxiong fine powder, spray into Oleum menthae, add polyethylene glycol 6000, Macrogol 4000, sodium lauryl sulphate, the mannitol mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly gets.
Embodiment 28
Prescription:
Crude drug: Radix Codonopsis 807g, Poria 717g, Rhizoma Atractylodis Macrocephalae 280g, Rhizoma Chuanxiong 434g, Pericarpium Citri Reticulatae 525g, Radix Astragali 1413g, Rhizoma Acori Graminei 484g;
Adjuvant: citric acid 600g (in anhydride), fumaric acid 400g, sodium bicarbonate 480g, sodium carbonate 600g, polyethylene glycol 6000 100g, Macrogol 4000 30g, sodium lauryl sulphate 10g, Pulvis Talci 10g, mannitol 100g, Oleum menthae (in right amount)
Method for making:
More than seven the flavor crude drug, get Rhizoma Chuanxiong power and be broken into fine powder, sieve; Six-element medical material decocte with water secondaries such as all the other Rhizoma Acori Graminei add 8 times of water gagings for the first time, add 8 times of water gagings for the second time; Each 3 hours, merge the secondary decocting liquid, filter; Filtrating is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), adds 7/10 Rhizoma Chuanxiong fine powder, mixing; 85 ℃ of dryings are ground into fine powder, sieve.Citric acid, fumaric acid, sodium bicarbonate and sodium carbonate are dry respectively, are ground into fine powder, sieve, and be subsequent use.Above-mentioned extract powder is divided into two parts, a citric acid, the fumaric acid fine powder of adding, mixing is processed granule, 85 ℃ of dryings, No. two sieve granulate; Another part adds sodium bicarbonate and sodium carbonate fine powder, and mixing is processed granule, 85 ℃ of dryings, No. two sieve granulate; Get residue Rhizoma Chuanxiong fine powder, spray into Oleum menthae, add polyethylene glycol 6000, Macrogol 4000, sodium lauryl sulphate, Pulvis Talci, the mannitol mixing is crossed 80 mesh sieves, adds above-mentioned two kinds of granules, and mixing is pressed into 1000, promptly gets.
Claims (4)
1. foot-bath effervescent tablet that improves subhealth state; This foot-bath effervescent tablet mainly is made up of effective ingredient, effervescent excipient and binding agent; It is characterized in that described effective ingredient is to form by the water extract of the Rhizoma Chuanxiong power of the percentage by weight 6%～25% of crude drug and following crude drug:
Radix Codonopsis 10%～30%, Poria 12%～35%, the Rhizoma Atractylodis Macrocephalae 6%～25%, Pericarpium Citri Reticulatae 6%～20%, the Radix Astragali 12%～35%, Rhizoma Acori Graminei 3%～15%.
2. a kind of foot-bath effervescent tablet that improves subhealth state according to claim 1 is characterized in that, described effective ingredient is to be made up of 10.75%～20.25% the Rhizoma Chuanxiong power and the water extract of following crude drug by the percentage by weight of crude drug:
Radix Codonopsis 15.00%～25.00%, Poria 17.75%～29.25%, the Rhizoma Atractylodis Macrocephalae 10.75%～20.25%, Pericarpium Citri Reticulatae 9.50%～16.50%, the Radix Astragali 18.50%～29.50%, Rhizoma Acori Graminei 6.00%～12.00%.
3. a kind of foot-bath effervescent tablet that improves subhealth state according to claim 2; It is characterized in that described effective ingredient is to be made up of 12.5% the Rhizoma Chuanxiong power and the water extract of following crude drug by the percentage by weight of crude drug: Radix Codonopsis 16.8%, Poria 19.8%; The Rhizoma Atractylodis Macrocephalae 12.5%; Pericarpium Citri Reticulatae 10.8%, the Radix Astragali 20.5%, Rhizoma Acori Graminei 7.1%.
4. according to claim 1,2 or 3 described a kind of foot-bath effervescent tablets that improve subhealth state, it is characterized in that described water extract is prepared by following method:
Get Radix Codonopsis, Poria, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, the Radix Astragali and Rhizoma Acori Graminei by proportioning, add 6-10 times of water gaging, decocted 1.5-3 hour, filter; Filtering residue adds 6-10 times of water gaging, decocts 1.5-3 hour, filters; Merge filtrating twice, concentrate, be drying to obtain.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010101797817A CN101829252B (en) | 2010-05-17 | 2010-05-17 | Footbath effervescent tablet for improving sub-health |
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| CN2010101797817A CN101829252B (en) | 2010-05-17 | 2010-05-17 | Footbath effervescent tablet for improving sub-health |
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| CN101829252B true CN101829252B (en) | 2012-07-04 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1344516A (en) * | 2001-09-14 | 2002-04-17 | 卢济台 | Healthy effervescent tablet and its prepn |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1344516A (en) * | 2001-09-14 | 2002-04-17 | 卢济台 | Healthy effervescent tablet and its prepn |
Non-Patent Citations (1)
| Title |
|---|
| 唐志鹏.慢性疲劳综合征的中医药研究概况.《广州中医药大学学报》.1998,第15卷第39-42页. * |
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