CN106214964A - Traditional Chinese medicine for soothing nerves preparation - Google Patents
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Classifications
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- A—HUMAN NECESSITIES
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- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8967—Lilium, e.g. tiger lily or Easter lily
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- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
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- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
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Abstract
The invention discloses a kind of Traditional Chinese medicine for soothing nerves preparation, raw material including following weight portion: Bulbus Lilii 10～50 parts, Rhizoma Polygonati Odorati 10～30 parts, Semen Ziziphi Spinosae 5～10 parts, Semen Cassiae 5～10 parts, Flos Chrysanthemi 5～10 parts, and A expects 2～5 parts, wherein, A material is the one or more of which in Fructus Jujubae, Poria and Semen Nelumbinis.The remarkable efficacy such as the present invention has clearing away heart-fire for tranquillization, nourishing the lung to arrest cough, and blood is adjusted in nourishing the liver, tonifying speen and tonifying kidney, can be used for fidgets due to deficiency cardiopalmus, nervous and insomnia and dreamful sleep, are also used for preventing and treating neurasthenia and depression.The present invention has no adverse reaction and toxic and side effects, calms the nerves, and sleeping and preventive treatment of disease and health preserving develop simultaneously.
Description
Technical field
The present invention relates to technical field of Chinese medicines.It is more particularly related to a kind of Traditional Chinese medicine for soothing nerves preparation.
Background technology
Bulbus Lilii, nature and flavor are sweet；Micro-hardship；It is slightly cold, returns careful；Lung meridian function cures mainly nourishing YIN and moistening the lung；Clearing away heart-fire for tranquillization.The main deficiency of YIN is long
Cough；Sputum mixed with blood；The calentura later stage；Waste heat is not clear, or the unsuccessful caused fidgets due to deficiency palpitation with fear of feelings will, insomnia and dreamful sleep, absentminded；Carbuncle
Swollen；Eczema.
Rhizoma Polygonati Odorati, sweet in the mouth, cold nature.Enter lung, stomach warp.Have yin nourishing, moisturize, relieving restlessness, effect of quenching the thirst.Control consumption of YIN caused by febrile disease,
Cough excessive thirst, deficient fever, rapid digestion of food easily famine, frequent micturition etc..Supplement to the Herbal carries " master is clever, adjust vim and vigour, make us strong ".
" Japan hanako materia medica " carries " relieving restlessness is vexed, quench the thirst, moisten cardiopulmonary, benefit five kinds of strain and seven kinds of impairment, deficient, waist foot pain pain, sky row are fanatical ".
Semen Cassiae, leguminous plant Semen Cassiae or the dry mature seed of little Semen Cassiae, the salty hardship of nature and flavor；Pingliang；Nontoxic, return Liver Channel；
Gallbladder meridian；Kidney channel, liver heat removing and eyesight improving, loosening bowel to relieve constipation.For the puckery pain of conjunctival congestion, the many tear of photophobia, dizziness of having a headache, poor vision, constipation.
Fructus Jujubae, Rhamnaceae machaka or dungarunga plant jujube tree, be also the mature fruit of jujube tree.Sweet in the mouth, property are flat, enter spleen,
Stomach warp；Strengthen the spleen and stomach, yin and blood nourishing, tranquilizing by nourishing the heart, relaxes effect of the property of medicine；For treating lack of appetite caused by deficiency of spleen-QI, letting out
Rushing down, cloudy women's hysteria syndrome caused by blood deficiency, the people that body is empty after being ill eats Fructus Jujubae also good tonic effect.Fructus Jujubae is always benefit
Gas, the health-care good product nourishing blood, calming the nerves are the most useful to patients such as hypertension, cardiovascular disease, insomnia, anemias.
Semen Ziziphi Spinosae is the dry mature seed of Rhamnaceae plant Ziziphi Spinosae.This product is sweet, sour, flat, enters the heart, liver, gallbladder meridian.Nourishing the liver,
Mind calming, calms the nerves, arresting sweating.Control restlessness of asrhenia type and insomnia, palpitation with a distress feeling of palpitating with fear, excessive thirst, sweating due to debility.
Semen Nelumbinis, the dry mature seed of nymphaeaceae plant lotus.Nature and flavor are sweet；Puckery；Flat.GUIXIN warp；Spleen channel；Kidney channel；Stomach warp；Liver
Warp；Bladder warp.Nourish heart, kidney tonifying, spleen reinforcing.Astringing intestine to stop diarrhea.Control dreaminess of sleeping night, seminal emission, stranguria with turbid discharge, chronic dysentery, diarrhea of deficiency type, married woman's bleeding not during menses.
Poria, Poria, it is commonly called as Poria, Song Ling, Poria, for colonizing in the fungi plant on pinaster root.Nature and flavor are sweet, light, flat.
GUIXIN, lung, spleen, kidney channel.Promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, loose stool has loose bowels, the heart
God is uneasy, palpitation with fear insomnia.
Flos Chrysanthemi, the perennial root herbaceous plant of Compositae Chrysanthemum.Sweet-bitter flavor, is slightly cold, and has dispelling wind, heat clearing away, improving eyesight, removing toxic substances
Effect.The diseases such as primary treatment headache, dizziness, conjunctival congestion, irritable feverish sensation of chest and heart, furuncle, toxic swelling.
Neurasthenia belongs to the one of mental illness, be one class spirit the most excited and mental the most tired, be often in a bad mood
The worried neurosis disorder with psychology physiological symptom.There is before a lot of patient bad character trait: feel oneself inferior, sensitive,
Suspicious, lack self-esteem or relatively subjective, irritable, seek to do others down anxious, thus be prone to cause the tension and relaxation insufficiency of accommodation to life events,
Brain is made to be chronically at persistence anxiety and fall ill.Most scholars thinks that Nervous and Mental Factors is to cause neurasthenic master at present
Cause.Every some factors that can cause lasting buck fever and long-term intrapsychic conflict, make neural activity process strong and hold
Long is in tension, exceedes the tolerance limit of nervous system tension force, can fall ill.As fatigue and can not get have a rest
It it is overstrain of excitatory process；Dissatisfied to present situation is then overstrain of inhibitory process；Often change living environment and
Inadaptable, make central nervous system be in hypertonicity and fatigue.Corticocerebral neurocyte has at a relatively high toleration,
After nervous mental work, although create fatigue, but just can recover after pausing to have a rest or sleep, but, the most by force
The neural activity of strong tense situation, once surmounts tolerance limit, it is possible to produce neurasthenia.Neurasthenic patient is often
Muscle tone pain, autonomic nervous dysfunction, the most nervous myalgia just had a headache or be unable to explain clearly, and companion occur
Have nervous, perspire, be off one's feed, dyspepsia, diarrhoea or constipation；Can also there is menoxenia in aeg, and Aeg then goes out
Existing sexual impotence, seminal emission, premature ejaculation etc..In terms of sleep, occur that various sleep disorder is also the most universal.
Depression is a kind of mode of onset of manic depressive illness.Subtract with hypothymergasia, retardation of thinking and speech action
Less, slow for classical symptom.Depression seriously perplexs the live and work of patient, brings white elephant to family and society,
The patients with depression of about 15% dies from suicide.The second serious disease that depression has become as China's Disease Spectrum is sick.Cause depression
Factor include: inherited genetic factors, physical factors, the function of nervus centralis media and Developmental and Metabolic Disorder, Nervous and Mental Factors etc..Depression master
Emotion to be shown as is the most low.It is typically in the people that social hierarchy is high, economic condition is good to be easier to suffer from depression.And
And the sickness rate of women is more much higher than male.Depressed from slightly feeling out of one's plate, upset, frustrated, can't be happy.
To pinched look, the sad despair secondary, depressed, pessimistic of worry, it it is all the listless performance of depression.Internal motivation lacks i.e.
What is not intended to do, and does not also know oneself to want What for, and what is the most nonsensical.Hebetude the lighter's interest goes down, and carries not
Playing excitement, time serious, interest is dull, is increasingly reluctant to participate in normal activity.Self evaluation is low feeling oneself inferior of saying exactly often, it is believed that oneself
Oneself does anything well, is good for nothing, and prospects are dim is unglazed, and severe one compunction is felt guilty；What is more, it is believed that The sin is great for oneself.
Suicidal idea and behavior suicidal idea the most just exist among the brains of depressive patients along with depressive emotion.Depression
The homicide rate of patient is higher 20 times than population.
Along with socio-economic development and global competition are aggravated, the study of people, obtain employment, work, live, family and thought
The nerves such as equal pressure and rhythm constantly increase or accelerates, and increasing people has the severe palpitation of malaise, insomnia and dreamful sleep
Diagonosis of disorder occurs, the crowd especially suffering from insomnia gradually sees huge, and the most vexed gas of these people is hot-tempered, absent minded,
Causing daytime listless owing to having a restless night, the traditional Chinese medical science thinks that anxiety impairing the spleen stomach, nervous disorder can cause stomach not received, acid regurgitation, loses
Dormancy can cause hypomnesis, absentminded, and insomnia mainly internal organs are become estranged, caused by disorder of QI and blood.
At present, it is to take Western medicine sleeping pill that vexed insomniac alleviates the usual method of this disease, such as: diazepam etc., but
Can not treat, long-term taking can form the dependence to sleeping pill at all, has untoward reaction and toxic and side effects, and long-term taking is also possible to
Causing the disease even more serious than insomnia, the Chinese medicine preparation of preventing and treating neurasthenia and depression lacks the most very much.Therefore, give full play to
Natural resources of Chinese medicinal materials and the advantage of compound preparation, develop new medicine of high quality and at a reasonable price to reach the effect of relieving mental strain and helping sleep, it has also become one
Plant exigence.Calm the nerves simultaneously and sleeping can still lack again in the research of Chinese medicine preparation of preventive treatment of disease and health preserving and application, need
Solve.
Summary of the invention
It is an object of the invention to solve the problems referred to above, and the advantage that at least will be described later is provided.
It is a still further object of the present invention to provide a kind of Traditional Chinese medicine for soothing nerves preparation, selected Bulbus Lilii, Rhizoma Polygonati Odorati, Poria, Semen Ziziphi Spinosae,
Semen Cassiae, Flos Chrysanthemi, Semen Nelumbinis, Herba Dendrobii, Radix Ophiopogonis, Radix Polygoni Multiflori Preparata, the drug matching preparation such as Radix Rehmanniae, there is clearing away heart-fire for tranquillization, nourishing the lung to arrest cough,
The remarkable efficacy such as blood is adjusted in nourishing the liver, tonifying speen and tonifying kidney, can be used for fidgets due to deficiency cardiopalmus, nervous and insomnia and dreamful sleep.
In order to realize according to object of the present invention and further advantage, it is provided that a kind of Traditional Chinese medicine for soothing nerves preparation, including
The raw material of following weight portion:
Bulbus Lilii 10～50 parts, Rhizoma Polygonati Odorati 10～30 parts, Semen Ziziphi Spinosae 5～10 parts, Semen Cassiae 5～10 parts, Flos Chrysanthemi 5～10 parts, with
And A expects 2～5 parts, wherein, described A material is the one or more of which in Fructus Jujubae, Poria and Semen Nelumbinis.
Preferably, including the raw material of following weight portion: Bulbus Lilii 40 parts, Rhizoma Polygonati Odorati 15 parts, Semen Ziziphi Spinosae 5 parts, Semen Cassiae 5 parts,
Flos Chrysanthemi 5 parts and 5 parts of Semen Nelumbinis.
Preferably, also include the raw material of following weight portion: B expect 5～10 parts, described B material for Herba Dendrobii, Radix Ophiopogonis, Radix Rehmanniae with
And one or more in Radix Polygoni Multiflori Preparata.
Preferably, Traditional Chinese medicine for soothing nerves preparation is tablet, granule, capsule, oral liquid or medicated wine.
Preferably, in the oral liquid made, every 400mL oral liquid includes Bulbus Lilii 10～50g, Rhizoma Polygonati Odorati 10～30g, acid
Semen Ziziphi Spinosae 5～10g, Semen Cassiae 5～10g, Flos Chrysanthemi 5～10g and Semen Nelumbinis 2～5g.
Present invention also offers the preparation method of the Traditional Chinese medicine for soothing nerves preparation of a kind of oral liquid formulation, comprise the following steps:
1) counting by weight, adding 100～200 parts of volume fractions after Bulbus Lilii 10～50 parts being pulverized is the ethanol of 95%
After, it is filtrated to get the first filtrate and the first filtering residue, after described first filtrate recycling ethanol, is added thereto to 200～400 parts of steamings
Distilled water, filters, obtains the second filtering residue and the second filtrate, described second filtrate is concentrated, obtains cold preservation 12h after the first clear paste, take cold
The first supernatant liquid filtering behind Tibetan obtains Bulbus Lilii filtrate；
2) count by weight, by Rhizoma Polygonati Odorati 10～30 parts, Semen Ziziphi Spinosae 5～10 parts, Semen Cassiae 5～10 parts, Flos Chrysanthemi 5～10 parts
And Semen Nelumbinis 2～5 parts mixing after pulverize, sieve, after adding 200～300 parts of distilled water, be filtrated to get the 3rd filtrate and the 3rd filter
Slag, after adding 100～200 parts of ethanol, filters, obtains the 4th filtering residue and the 4th filtrate, reclaim ethanol in described 3rd filtrate
After, described 4th filtrate is concentrated, obtains cold preservation 12h after the second clear paste, take the second supernatant liquid filtering after cold preservation and must mix filtrate；
3) count by weight, described mixing filtrate joined in described Bulbus Lilii filtrate, adds 200～400 parts of distilled water,
Boil and stand 12 hours after 10min, take the 3rd supernatant liquid filtering, collect filtrate, after filtrate is boiled 30min, add 100～
The Traditional Chinese medicine for soothing nerves preparation of oral liquid formulation is obtained after 200 parts of distilled water.
Preferably, described first clear paste density is 1.03g/mL, and described second clear paste density is 1.06g/mL.
Present invention also offers the preparation method of the Traditional Chinese medicine for soothing nerves preparation of a kind of tablet form, comprise the following steps:
S1, counting by weight, after Bulbus Lilii 10～50 parts being pulverized, adding 60～100 parts of volume fractions is the second of 50%
After alcohol extracts 1h at 50 DEG C, it is filtrated to get the 5th filtrate and the 5th filtering residue, in described 5th filtering residue, adds 50～80 parts of bodies
Fraction is after the ethanol of 75% extracts 1h at 55 DEG C, to be filtrated to get the 6th filtrate and the 6th filtering residue, to described 6th filtering residue
Middle addition 50～60 parts of volume fractions are, after the ethanol of 95% extracts 1h at 60 DEG C, to be filtrated to get extracting solution；
S2, count by weight, described extracting solution, described 5th filtrate and described 6th filtrate are separately recovered ethanol
After, obtain mixed liquor after mixing, by Rhizoma Polygonati Odorati 10～30 parts, Semen Ziziphi Spinosae 5～10 parts, Semen Cassiae 5～10 parts, Flos Chrysanthemi 5～10 parts with
And Semen Nelumbinis 2～5 parts mixing after pulverize, sieve, after adding 100～200 parts of distilled water, be filtrated to get the 7th filtrate and the 7th filter
Slag, after adding described 7th filtrate in described mixed liquor, mixing, cold preservation 2～4h at-8～-4 DEG C, filter, obtain the 8th
Filtering residue and the 8th filtrate, concentrate described 8th filtrate, obtain thick paste；
S3, count by weight, add in described thick paste 3 parts as the lactose of adjuvant after, tabletting is the peace of tablet form
The Chinese medicine preparation of god.
Effective dose and using method: oral: tablet: one time 2～4, every day 1～3 times；Oral liquid: one time 10～20ml,
Every day 2～5 times.Children taking decrement is also followed the doctor's advice.
The present invention at least includes following beneficial effect:
1, the present invention provides a kind of Traditional Chinese medicine for soothing nerves preparation, and the present invention passes on traditional Chinese medicine theory, selected Bulbus Lilii, jade
Bamboo, Poria, Semen Ziziphi Spinosae, Semen Cassiae, Flos Chrysanthemi, Semen Nelumbinis, Herba Dendrobii, Radix Ophiopogonis, Radix Polygoni Multiflori Preparata, the drug matching preparation such as Radix Rehmanniae, form spy
Color, wherein Bulbus Lilii is apt to clearing away heart-fire for tranquillization, and for we's monarch drug, Rhizoma Polygonati Odorati, Herba Dendrobii, Radix Ophiopogonis, Radix Polygoni Multiflori Preparata, Radix Rehmanniae is apt to nourshing Yin and drynsessmoistening prescription, yin nourishing
YANG hyperactivity suppressing, for we's ministerial drug, Semen Ziziphi Spinosae, Semen Cassiae, Flos Chrysanthemi be apt to heat clearing away and dispel tired, suppressing the hyperactive liver soothing liver-QI, restrains hidroschesis, and loosening bowel to relieve constipation, for this
Side's adjuvant drug, Poria, Fructus Jujubae, Semen Nelumbinis are apt to blood-enriching qi-invigorating, promoting diuresis to eliminate damp pathogen, and spleen invigorating mind calming, and coordinating the actions of various ingredients in a prescription, for adjuvant.Above-mentioned all medicines
Compatibility agent, learns from other's strong points to offset one's weaknesses, and works in coordination with and makes a concerted effort, and implements clearing away heart-fire for tranquillization, nourishing the lung to arrest cough, the remarkable efficacy such as blood is adjusted in nourishing the liver, tonifying speen and tonifying kidney,
Can be used for fidgets due to deficiency cardiopalmus, nervous and insomnia and dreamful sleep, hypertension is also had certain therapeutical effect.
2, the Traditional Chinese medicine for soothing nerves preparation of the present invention is strengthened nervous system such as brain, vegetative nerve, sympathetic nerve function pair
To regulation effect it can also be used to prevent and treat neurasthenia and depression.
3, the present invention Traditional Chinese medicine for soothing nerves preparation strengthen Endocrine system dual regulation it can also be used to women more
The anti-treatment of term syndrome.
4, the Traditional Chinese medicine for tranquilization of the present invention can coordinate pharmacy to allow adjuvant, makes granule, tablet, capsule, oral liquid, wine
Agent etc., are suitable for different crowd hobby, have no adverse reaction and toxic and side effects, calm the nerves, and sleeping and preventive treatment of disease and health preserving develop simultaneously.
5, by major ingredient Bulbus Lilii and Rhizoma Polygonati Odorati, Semen Ziziphi Spinosae, Semen Cassiae, Flos Chrysanthemi and the mixing of Semen Nelumbinis in the preparation method of the present invention
It is respectively adopted alcohol extracting-water precipitating and water extract-alcohol precipitation, takes different extracting method for different medicines, the extraction to active component
More abundant, neither affect the respective property of medicine such as monarch medicine, and extraction ratio and raw material utilization rate higher.
Part is embodied by the further advantage of the present invention, target and feature by description below, and part also will be by this
Invention research and practice and be understood by the person skilled in the art.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail, to make those skilled in the art with reference to description
Word can be implemented according to this.
Embodiment 1
A kind of Traditional Chinese medicine for soothing nerves preparation, including the raw material of following weight portion:
Bulbus Lilii 10 parts, Rhizoma Polygonati Odorati 10 parts, Semen Ziziphi Spinosae 5 parts, Semen Cassiae 5 parts, Flos Chrysanthemi 5 parts, and A expect 2 parts, and wherein, described A expects
For Fructus Jujubae.
Embodiment 2
A kind of Traditional Chinese medicine for soothing nerves preparation, including the raw material of following weight portion:
Bulbus Lilii 50 parts, Rhizoma Polygonati Odorati 30 parts, Semen Ziziphi Spinosae 10 parts, Semen Cassiae 10 parts, Flos Chrysanthemi 10 parts, and A expect 5 parts, wherein, described
A material is Poria.
Embodiment 3
A kind of Traditional Chinese medicine for soothing nerves preparation, including the raw material of following weight portion:
Bulbus Lilii 30 parts, Rhizoma Polygonati Odorati 20 parts, Semen Ziziphi Spinosae 8 parts, Semen Cassiae 8 parts, Flos Chrysanthemi 8 parts, and A expect 3 parts, and wherein, described A expects
For Fructus Jujubae that weight ratio is 1:1 and Poria.
Embodiment 4
A kind of Traditional Chinese medicine for soothing nerves preparation, including the raw material of following weight portion:
Bulbus Lilii 40 parts, Rhizoma Polygonati Odorati 15 parts, Semen Ziziphi Spinosae 5 parts, Semen Cassiae 5 parts, Flos Chrysanthemi 5 parts, and A expect 5 parts, and wherein, described A expects
For Semen Nelumbinis.
Embodiment 5
A kind of Traditional Chinese medicine for soothing nerves preparation, including the raw material of following weight portion:
Bulbus Lilii 10 parts, Rhizoma Polygonati Odorati 10 parts, Semen Ziziphi Spinosae 5 parts, Semen Cassiae 5 parts, Flos Chrysanthemi 5 parts, and A expect 2 parts, and B expects 5 parts, wherein,
Described A material is Fructus Jujubae, and described B material is Herba Dendrobii.
Embodiment 6
A kind of Traditional Chinese medicine for soothing nerves preparation, including the raw material of following weight portion:
Bulbus Lilii 50 parts, Rhizoma Polygonati Odorati 30 parts, Semen Ziziphi Spinosae 10 parts, Semen Cassiae 10 parts, Flos Chrysanthemi 10 parts, and A expect 5 parts, and B expects 10 parts,
Wherein, described A material is the Fructus Jujubae of 2:1:1, Poria and Semen Nelumbinis for weight ratio, described B expect for Herba Dendrobii that weight ratio is 1:3:1:1,
Radix Ophiopogonis, Radix Rehmanniae and Radix Polygoni Multiflori Preparata.
Embodiment 7
A kind of Traditional Chinese medicine for soothing nerves preparation, including the raw material of following weight portion:
Bulbus Lilii 30 parts, Rhizoma Polygonati Odorati 20 parts, Semen Ziziphi Spinosae 7 parts, Semen Cassiae 8 parts, Flos Chrysanthemi 8 parts, and A expect 3 parts, and B expects 8 parts, wherein,
Described A material is 2:1 Fructus Jujubae and Poria for weight ratio, and described B expects the Radix Ophiopogonis for weight ratio is 3:1 and Radix Rehmanniae.
Embodiment 8
1) count by weight, after 100 parts of volume fractions of addition are the ethanol of 95% after being pulverized by Bulbus Lilii 10 parts, filter
To the first filtrate and the first filtering residue, after described first filtrate recycling ethanol, it is added thereto to 200 parts of distilled water, filters, obtain
Second filtering residue and the second filtrate, concentrate described second filtrate, obtain cold preservation 12h after the first clear paste that density is 1.03g/mL, take
The first supernatant liquid filtering after cold preservation obtains Bulbus Lilii filtrate；
2) count by weight, by Rhizoma Polygonati Odorati 10 parts, Semen Ziziphi Spinosae 5 parts, Semen Cassiae 5 parts, Flos Chrysanthemi 5 parts and the mixing of 2 parts of Semen Nelumbinis
Rear pulverizing, sieves, and after adding 200 parts of distilled water, is filtrated to get the 3rd filtrate and the 3rd filtering residue, adds in described 3rd filtrate
After 100 parts of ethanol, filter, obtain the 4th filtering residue and the 4th filtrate, after reclaiming ethanol, described 4th filtrate is concentrated, obtains density
For cold preservation 12h after second clear paste of 1.06g/mL, take the second supernatant liquid filtering after cold preservation and must mix filtrate；
3) count by weight, described mixing filtrate is joined in described Bulbus Lilii filtrate, adds 200 parts of distilled water, boil
Stand 12 hours after 10min, take the 3rd supernatant liquid filtering, collect filtrate, after filtrate is boiled 30min, add 100 parts of distilled water
After obtain the Traditional Chinese medicine for soothing nerves preparation of oral liquid formulation.
Embodiment 9
1) count by weight, after 200 parts of volume fractions of addition are the ethanol of 95% after being pulverized by Bulbus Lilii 50 parts, filter
To the first filtrate and the first filtering residue, after described first filtrate recycling ethanol, it is added thereto to 400 parts of distilled water, filters, obtain
Second filtering residue and the second filtrate, concentrate described second filtrate, obtain cold preservation 12h after the first clear paste that density is 1.03g/mL, take
The first supernatant liquid filtering after cold preservation obtains Bulbus Lilii filtrate；
2) count by weight, Rhizoma Polygonati Odorati 30 parts, Semen Ziziphi Spinosae 10 parts, Semen Cassiae 10 parts, Flos Chrysanthemi 10 parts and 5 parts of Semen Nelumbinis are mixed
Pulverize after conjunction, sieve, after adding 300 parts of distilled water, be filtrated to get the 3rd filtrate and the 3rd filtering residue, add in described 3rd filtrate
After entering 200 parts of ethanol, filter, obtain the 4th filtering residue and the 4th filtrate, after reclaiming ethanol, described 4th filtrate is concentrated, obtains close
Degree is cold preservation 12h after second clear paste of 1.06g/mL, takes the second supernatant liquid filtering after cold preservation and must mix filtrate；
3) count by weight, described mixing filtrate is joined in described Bulbus Lilii filtrate, adds 400 parts of distilled water, boil
Stand 12 hours after 10min, take the 3rd supernatant liquid filtering, collect filtrate, after filtrate is boiled 30min, add 200 parts of distilled water
After obtain the Traditional Chinese medicine for soothing nerves preparation of oral liquid formulation.
Embodiment 10
1) count by weight, after 150 parts of volume fractions of addition are the ethanol of 95% after being pulverized by Bulbus Lilii 30 parts, filter
To the first filtrate and the first filtering residue, after described first filtrate recycling ethanol, it is added thereto to 300 parts of distilled water, filters, obtain
Second filtering residue and the second filtrate, concentrate described second filtrate, obtain cold preservation 12h after the first clear paste that density is 1.03g/mL, take
The first supernatant liquid filtering after cold preservation obtains Bulbus Lilii filtrate；
2) count by weight, by Rhizoma Polygonati Odorati 20 parts, Semen Ziziphi Spinosae 8 parts, Semen Cassiae 8 parts, Flos Chrysanthemi 8 parts and the mixing of 3 parts of Semen Nelumbinis
Rear pulverizing, sieves, and after adding 250 parts of distilled water, is filtrated to get the 3rd filtrate and the 3rd filtering residue, adds in described 3rd filtrate
After 150 parts of ethanol, filter, obtain the 4th filtering residue and the 4th filtrate, after reclaiming ethanol, described 4th filtrate is concentrated, obtains density
For cold preservation 12h after second clear paste of 1.06g/mL, take the second supernatant liquid filtering after cold preservation and must mix filtrate；
3) count by weight, described mixing filtrate is joined in described Bulbus Lilii filtrate, adds 300 parts of distilled water, boil
Stand 12 hours after 10min, take the 3rd supernatant liquid filtering, collect filtrate, after filtrate is boiled 30min, add 150 parts of distilled water
After obtain the Traditional Chinese medicine for soothing nerves preparation of oral liquid formulation.
Embodiment 11
S1, counting by weight, after being pulverized by Bulbus Lilii 10 parts, adding 60 parts of volume fractions is that the ethanol of 50% is at 50 DEG C
After extracting 1h, being filtrated to get the 5th filtrate and the 5th filtering residue, adding 50 parts of volume fractions in described 5th filtering residue is 75%
After ethanol extracts 1h at 55 DEG C, it is filtrated to get the 6th filtrate and the 6th filtering residue, in described 6th filtering residue, adds 50～60 parts
Volume fraction is, after the ethanol of 95% extracts 1h at 60 DEG C, to be filtrated to get extracting solution；
S2, count by weight, described extracting solution, described 5th filtrate and described 6th filtrate are separately recovered ethanol
After, obtain mixed liquor after mixing, powder after Rhizoma Polygonati Odorati 10 parts, Semen Ziziphi Spinosae 5 parts, Semen Cassiae 5 parts, Flos Chrysanthemi 5 and 2 parts of Semen Nelumbinis being mixed
Broken, sieve, after adding 100 parts of distilled water, be filtrated to get the 7th filtrate and the 7th filtering residue, in described mixed liquor, add described
After seven filtrates, mixing, cold preservation 2h at-8 DEG C, filter, obtain the 8th filtering residue and the 8th filtrate, described 8th filtrate is concentrated,
Obtain thick paste；
S3, count by weight, add in described thick paste 3 parts as the lactose of adjuvant after, tabletting is the peace of tablet form
The Chinese medicine preparation of god.
Embodiment 12
S1, counting by weight, after being pulverized by Bulbus Lilii 50 parts, adding 100 parts of volume fractions is that the ethanol of 50% is at 50 DEG C
After lower extraction 1h, being filtrated to get the 5th filtrate and the 5th filtering residue, adding 80 parts of volume fractions in described 5th filtering residue is 75%
Ethanol at 55 DEG C, extract 1h after, be filtrated to get the 6th filtrate and the 6th filtering residue, in described 6th filtering residue add 60 parts of bodies
Fraction is, after the ethanol of 95% extracts 1h at 60 DEG C, to be filtrated to get extracting solution；
S2, count by weight, described extracting solution, described 5th filtrate and described 6th filtrate are separately recovered ethanol
After, obtain mixed liquor after mixing, by Rhizoma Polygonati Odorati 30 parts, Semen Ziziphi Spinosae 10 parts, Semen Cassiae 10 parts, Flos Chrysanthemi 10 parts and the mixing of 5 parts of Semen Nelumbinis
Rear pulverizing, sieves, and after adding 200 parts of distilled water, is filtrated to get the 7th filtrate and the 7th filtering residue, adds institute in described mixed liquor
After stating the 7th filtrate, mixing, cold preservation 4h at-4 DEG C, filters, obtains the 8th filtering residue and the 8th filtrate, by dense for described 8th filtrate
Contracting, obtains thick paste；
S3, count by weight, add in described thick paste 3 parts as the lactose of adjuvant after, tabletting is the peace of tablet form
The Chinese medicine preparation of god.
Embodiment 13
S1, counting by weight, after being pulverized by Bulbus Lilii 30 parts, adding 80 parts of volume fractions is that the ethanol of 50% is at 50 DEG C
After extracting 1h, being filtrated to get the 5th filtrate and the 5th filtering residue, adding 60 parts of volume fractions in described 5th filtering residue is 75%
After ethanol extracts 1h at 55 DEG C, it is filtrated to get the 6th filtrate and the 6th filtering residue, in described 6th filtering residue, adds 55 parts of volumes
Mark is, after the ethanol of 95% extracts 1h at 60 DEG C, to be filtrated to get extracting solution；
S2, count by weight, described extracting solution, described 5th filtrate and described 6th filtrate are separately recovered ethanol
After, obtain mixed liquor after mixing, powder after Rhizoma Polygonati Odorati 20 parts, Semen Ziziphi Spinosae 8 parts, Semen Cassiae 8 parts, Flos Chrysanthemi 8 parts and 3 parts of Semen Nelumbinis being mixed
Broken, sieve, after adding 150 parts of distilled water, be filtrated to get the 7th filtrate and the 7th filtering residue, in described mixed liquor, add described
After seven filtrates, mixing, cold preservation 3h at-6 DEG C, filter, obtain the 8th filtering residue and the 8th filtrate, described 8th filtrate is concentrated,
Obtain thick paste；
S3, count by weight, add in described thick paste 3 parts as the lactose of adjuvant after, tabletting is the peace of tablet form
The Chinese medicine preparation of god.
The effect of the present invention is described below in conjunction with clinical laboratory data:
1, the impact on sleep
Effect of 1.1 relieving mental strain and helping sleeps
One, clinical experiment is observed: 90 example clinical manifestations are carried out by the present invention for having a sleepless night, suffering from slight neurasthenic patient
Clinical trial, stochastic averagina is divided into 3 groups, and wherein treatment group uses medicine prepared by the formula of the present embodiment 4, matched group 1 to take orally
Stable, matched group 2 does not take any medicine.Before carrying out this experiment, selected 90 example patients did not all accept any treatment.
Two, usage and dosage: during clinical practice, oral liquid formulation prepared by the formula of the present embodiment 4 taking the present invention
Traditional Chinese medicine for soothing nerves preparation, each 15ml, three times a day, five days is a course for the treatment of.Avoid cold and uncooked food during treatment the thing of pungent stimulation.
Three, efficacy determination: effective: within 2 courses for the treatment of of medication, insomnia alleviates, insomnia and slight god within 4 courses for the treatment of
Disappear through weak sign, and nothing recurrence in more than 3 months；Effective: within 2 courses for the treatment of of medication, insomnia alleviated, within 4 courses for the treatment of
Insomnia and slight neurasthenia's part sign disappear；Invalid: medication is had a sleepless night and the slight equal nothing of neurasthenia's sign within 4 courses for the treatment of
Substantially alleviate and improve.
Four, the statistical result of effect of relieving mental strain and helping sleep such as table 1 below:
The statistical result of effect of table 1 relieving mental strain and helping sleep
By the statistical result of table 1 it can be seen that Traditional Chinese medicine for soothing nerves preparation provided by the present invention declines for insomnia and nerve
Weak is evident in efficacy.
1.2 effects improving sleep quality
Clinical experiment is observed: the patient's Minute in above-mentioned treatment group, matched group 1 and matched group 2 is added up by the present invention
Time for falling asleep and the meansigma methods of the length of one's sleep, wherein, time for falling asleep arrives time asleep, in combination with part A Sen after referring to turn off the light
This insomnia scale statistics revives night, than expected time early awakening, sleep quality, the meansigma methods of scoring of daytime is drowsy four indices
Evaluate sleep quality.
Table 2 part Athens insomnia scale standards of grading
Time for falling asleep, the length of one's sleep and other index integration situations before and after table 3 treatment group and matched group test
As can be seen from Table 3, owing to having taken the Traditional Chinese medicine for soothing nerves preparation of the present invention in treatment group, than test after test
Front time for falling asleep substantially shortens, and the length of one's sleep significantly extends, and total mark declines to a great extent, and takes stable in matched group 1, although
Also improve sleep but the change of each item data is substantially not as treatment group, prove compared with matched group 2 in the calming the nerves of the present invention
Medicine preparation tool is significantly improved effect of sleep quality, simultaneously the Traditional Chinese medicine for soothing nerves preparation of the present invention improve sleep quality
Effect is substantially better than currently used stable medicine such as grade and has no side effect.
2, the effect to depression
2.1, physical data
In 50 example patients, women 32 example, male 18 example, at minimum 16 years old of age, maximum 67 years old, the course of disease was many at 6 months to 5
Year, 42.5 years old mean age.
2.2, diagnostic criteria
According to the diagnostic criteria of " Chinese Spirit Obstacles classification and diagnostic criteria the 3rd edition " depression, Hamilton is depressed
First 17 >=18 points of scale (HAMD), without other neuropsychiatric diseases, alcohol-free and drug dependence and similar medicine allergies, row
Except the diseases such as the heart, liver, kidney are divided, without other neuropsychiatric diseases, alcohol-free and drug dependence and similar medicine allergies, get rid of
The diseases such as the heart, liver, kidney.
2.3, Therapeutic Method: take the Traditional Chinese medicine for soothing nerves system of oral liquid formulation prepared by the formula of embodiments of the invention 4
Agent, each 15ml, three times a day, five days is a course for the treatment of.
2.4, therapeutic outcome: use HAMD evaluate clinical efficacy, with HAMD deduction rate evaluate, use recovery from illness, effective, invalid
3 grades of standards of grading, deduction rate>=75% is recovery from illness, and 25～75% is that effectively<25% is invalid.
In 50 example patients, 18 examples of fully recovering, effective 21 examples, invalid 11 examples, total effective rate is 78%.
2.5, model case
Week certain, man, 19 years old, because college entrance examination mood of failing in an entrance examination for twice is gloomy, several nights did not slept, and have suffered from depression, the biggest noisy
Create an uproar in, pound and fall thing, get around.Once went to many hospitals in the whole nation, and alleviated though having through western medicine symptom, but often recur,
Take Traditional Chinese medicine for soothing nerves preparation prepared by the formula of embodiments of the invention 4 to treat, thorough rehabilitation after four courses for the treatment of.
Lee, female, 58 years old, because family's reason has suffered from depression, frequent heart occurred gloomy, lonely, dreary, grieved, funeral
Lose and kith and kin, the extraneous interest exchanging dealing, frequently sigh, dejected, sobbing.Once many medicines were used all not prove effective.Take
Traditional Chinese medicine for soothing nerves preparation prepared by the formula of embodiments of the invention 4 is treated, and after five courses for the treatment of, disease obtains recovery from illness.
3, the effect to climacteric syndrome
Model case 1: Liu, female, 45 years old, people from Jiangxi Province.Patient's dysphoria all day of self-induction over one year, yawn work frequently,
Irritable feverish sensation of chest and heart, hospital examines as climacteric syndrome.Integrative therapy, weighs time light during symptom, meets exacerbation of symptoms after direct stimulation, suffers from
Person checked in October, 2011, red tongue, few tongue, and thready and rapid pulse is examined and can not be reposed for dirty deficiency of YIN, blood deficiency, gives the reality of the present invention
After 5 courses for the treatment of of Traditional Chinese medicine for soothing nerves preparation for treating executing prepared by the formula of example 4, symptom is wholly absent, patient's rehabilitation, follows up a case by regular visits to 1 year
Without recurrence.
Model case 2: Zhao so-and-so, female, 53 years old, people from Anhui Province.In June, 2011 goes to a doctor, and readme irregular menstrual period is
1 year.The a burst of heating of conscious Head And Face, sweating, irritable, sometimes feverish sensation in the palms and soles.Have a medical check-up: red tongue white and thin fur, stringy and thready pulse.
Examine as climacteric syndrome, genus deficiency of both YIN and YANG.Give Traditional Chinese medicine for soothing nerves preparation prepared by the formula of embodiments of the invention 4, clothes
With 5 courses for the treatment of, subjective symptoms substantially alleviates, and continues to take for 5 courses for the treatment of, and all diseases disappear and fully recover.Follow up a case by regular visits to not recur the most again.
Model case 3: Song, female, 56 years old, people from Anhui Province.In April, 2011 goes to a doctor, and menstruation has stopped half a year, conscious week
Body is uncomfortable, hectic fever, sweating, vexed insomnia, kind worry of thinking much.Examine as climacteric syndrome.Give the formula system of the embodiment of the present invention 4
2 courses for the treatment of taken by standby Traditional Chinese medicine for soothing nerves preparation, and the symptom such as hectic fever, sweating substantially alleviates, and continue to take 3 courses for the treatment of, and symptom disappears
Lose, recovery from illness, follow up a case by regular visits to not recur the most again.
4, the therapeutical effect to hypertension
1) clinical experiment is observed: the present invention carries out clinical trial to the patient that 60 example clinical manifestations are hypertension, puts down at random
Being divided into 2 groups, wherein medication group uses the medicine of embodiment 10, blank group not to take any medicine.Carry out before this experiment, institute
60 example patients are selected all not accept any treatment.
2) usage and dosage: during clinical practice, takes in the calming the nerves of oral liquid formulation of embodiments of the invention 10 preparation
Medicine preparation, each 15ml, three times a day, five days is a course for the treatment of.Avoid cold and uncooked food during treatment the thing of pungent stimulation.
3) efficacy determination:
Hypertension standard: 1 grade of hypertension: shrink pressure 140～159mmHg；Diastolic pressure 90～99mmHg；2 grades of hypertension: receive
Contractive pressure 160～179mmHg；Diastolic pressure 100～109mmHg；3 grades of hypertension: shrink pressure >=180mmHg；Diastolic pressure >=
110mmHg。
Treatment standard:
Cure: adult's blood pressure continue or non-on the same day three times shrink pressure be 130～140mmHg and/or diastolic pressure >=90～
85mmHg；
Effective: blood pressure level reduces a grade；
Effective: blood pressure has 5～10mmHg to reduce before relatively treating.
4) the statistical result such as table 4 below to the therapeutical effect of hypertension:
The table 4 statistical result to the therapeutical effect of hypertension
By the statistical result of table 4 it can be seen that Traditional Chinese medicine for soothing nerves preparation provided by the present invention has one for hypertension
Fixed curative effect, can be as the ancillary drug for the treatment of hypertension.
5) model case
(1) journey, man, suffer from hypertension 1 year, high pressure 150mmHg, low pressure 95mmHg, take the oral liquid formulation of the present invention
10 courses for the treatment of of Traditional Chinese medicine for soothing nerves preparation after, blood pressure drops to high pressure 130mmHg, low pressure 90mmHg.
(2) together certain, female, suffer from hypertension 4 years, high pressure 160mmHg, low pressure 110mmHg, take the oral liquid formulation of the present invention
20 courses for the treatment of of Traditional Chinese medicine for soothing nerves preparation after, blood pressure reduces, high pressure 145mmHg, low pressure 100mmHg.
Although embodiment of the present invention are disclosed as above, but it is not restricted in description and embodiment listed
Using, it can be applied to various applicable the field of the invention completely, for those skilled in the art, and can be easily
Realizing other amendment, therefore under the general concept limited without departing substantially from claim and equivalency range, the present invention does not limit
In specific details with shown here as the embodiment with description.
Claims (8)
1. a Traditional Chinese medicine for soothing nerves preparation, it is characterised in that include the raw material of following weight portion:
Bulbus Lilii 10～50 parts, Rhizoma Polygonati Odorati 10～30 parts, Semen Ziziphi Spinosae 5～10 parts, Semen Cassiae 5～10 parts, Flos Chrysanthemi 5～10 parts, and A material
2～5 parts, wherein, described A material is the one or more of which in Fructus Jujubae, Poria and Semen Nelumbinis.
2. Traditional Chinese medicine for soothing nerves preparation as claimed in claim 1, it is characterised in that include the raw material of following weight portion: Bulbus Lilii 40
Part, Rhizoma Polygonati Odorati 15 parts, Semen Ziziphi Spinosae 5 parts, Semen Cassiae 5 parts, Flos Chrysanthemi 5 parts and 5 parts of Semen Nelumbinis.
3. Traditional Chinese medicine for soothing nerves preparation as claimed in claim 1, it is characterised in that also include the raw material of following weight portion: B material 5
～10 parts, described B material is one or more in Herba Dendrobii, Radix Ophiopogonis, Radix Rehmanniae and Radix Polygoni Multiflori Preparata.
4. Traditional Chinese medicine for soothing nerves preparation as claimed in claim 1, it is characterised in that Traditional Chinese medicine for soothing nerves preparation be tablet, granule,
Capsule, oral liquid or medicated wine.
5. Traditional Chinese medicine for soothing nerves preparation as claimed in claim 4, it is characterised in that every 400mL oral liquid in the oral liquid made
Include Bulbus Lilii 10～50g, Rhizoma Polygonati Odorati 10～30g, Semen Ziziphi Spinosae 5～10g, Semen Cassiae 5～10g, Flos Chrysanthemi 5～10g and Semen Nelumbinis 2～
5g。
6. the preparation method of the Traditional Chinese medicine for soothing nerves preparation of an oral liquid formulation, it is characterised in that comprise the following steps:
1) count by weight, after after Bulbus Lilii 10～50 parts being pulverized, 100～200 parts of volume fractions of addition are the ethanol of 95%,
It is filtrated to get the first filtrate and the first filtering residue, after described first filtrate recycling ethanol, is added thereto to 200～400 parts of distillations
Water, filters, obtains the second filtering residue and the second filtrate, described second filtrate is concentrated, obtains cold preservation 12h after the first clear paste, take cold preservation
After the first supernatant liquid filtering obtain Bulbus Lilii filtrate；
2) count by weight, by Rhizoma Polygonati Odorati 10～30 parts, Semen Ziziphi Spinosae 5～10 parts, Semen Cassiae 5～10 parts, Flos Chrysanthemi 5～10 parts and
Pulverize after Semen Nelumbinis 2～5 parts of mixing, sieve, after adding 200～300 parts of distilled water, be filtrated to get the 3rd filtrate and the 3rd filtering residue,
After adding 100～200 parts of ethanol in described 3rd filtrate, filter, obtain the 4th filtering residue and the 4th filtrate, after reclaiming ethanol,
Described 4th filtrate is concentrated, obtains cold preservation 12h after the second clear paste, take the second supernatant liquid filtering after cold preservation and must mix filtrate；
3) count by weight, described mixing filtrate is joined in described Bulbus Lilii filtrate, adds 200～400 parts of distilled water, boil
Stand 12 hours after 10min, take the 3rd supernatant liquid filtering, collect filtrate, after filtrate is boiled 30min, add 100～200 parts
The Traditional Chinese medicine for soothing nerves preparation of oral liquid formulation is obtained after distilled water.
7. the preparation method of the Traditional Chinese medicine for soothing nerves preparation of oral liquid formulation as claimed in claim 6, it is characterised in that described the
One clear paste density is 1.03g/mL, and described second clear paste density is 1.06g/mL.
8. the preparation method of the Traditional Chinese medicine for soothing nerves preparation of a tablet form, it is characterised in that comprise the following steps:
S1, count by weight, after Bulbus Lilii 10～50 parts are pulverized, add the ethanol that 60～100 parts of volume fractions are 50% and exist
After extracting 1h at 50 DEG C, it is filtrated to get the 5th filtrate and the 5th filtering residue, in described 5th filtering residue, adds 50～80 parts of volume integrals
Number is, after the ethanol of 75% extracts 1h at 55 DEG C, to be filtrated to get the 6th filtrate and the 6th filtering residue, adds in described 6th filtering residue
Entering 50～60 parts of volume fractions is, after the ethanol of 95% extracts 1h at 60 DEG C, to be filtrated to get extracting solution；
S2, count by weight, after described extracting solution, described 5th filtrate and described 6th filtrate are separately recovered ethanol, mixed
Mixed liquor is obtained, by Rhizoma Polygonati Odorati 10～30 parts, Semen Ziziphi Spinosae 5～10 parts, Semen Cassiae 5～10 parts, Flos Chrysanthemi 5～10 parts and Semen Nelumbinis after conjunction
Pulverize after 2～5 parts of mixing, sieve, after adding 100～200 parts of distilled water, be filtrated to get the 7th filtrate and the 7th filtering residue, to institute
State after mixed liquor adds described 7th filtrate, mixing, cold preservation 2～4h at-8～-4 DEG C, filter, obtain the 8th filtering residue and the
Eight filtrates, concentrate described 8th filtrate, obtain thick paste；
S3, count by weight, add in described thick paste 3 parts as the lactose of adjuvant after, tabletting is calming the nerves of tablet form
Chinese medicine preparation.
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| CN107050281A (en) * | 2017-02-15 | 2017-08-18 | 范茜 | It is a kind of to treat Chinese medicine composition of arrhythmia cordis and preparation method thereof |
| CN108740185A (en) * | 2018-05-07 | 2018-11-06 | 合肥御和轩养生科技有限公司 | A kind of improvement sleep health preserving tea and its preparation process |
| CN110354200A (en) * | 2019-06-30 | 2019-10-22 | 杨顺平 | Jujube kernel water lily beans |
| CN110638945A (en) * | 2019-09-26 | 2020-01-03 | 宁波德康生物制品有限公司 | Nerve-soothing and sleep-aiding substitutional tea and preparation method thereof |
| CN111227155A (en) * | 2020-03-31 | 2020-06-05 | 清远创春园食品生产有限公司 | Wild jujube seed and chrysanthemum solid beverage and preparation method thereof |
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| CN104127698A (en) * | 2014-07-15 | 2014-11-05 | 湖南龙石山铁皮石斛基地有限公司 | Traditional Chinese medicinal composition for nerve calming and melancholy dispelling, and preparation method and application thereof |
| CN104146087A (en) * | 2014-07-18 | 2014-11-19 | 刘彦峰 | Method for preparing traditional Chinese medicine nerve-calming tea |
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Cited By (5)
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| CN107050281A (en) * | 2017-02-15 | 2017-08-18 | 范茜 | It is a kind of to treat Chinese medicine composition of arrhythmia cordis and preparation method thereof |
| CN108740185A (en) * | 2018-05-07 | 2018-11-06 | 合肥御和轩养生科技有限公司 | A kind of improvement sleep health preserving tea and its preparation process |
| CN110354200A (en) * | 2019-06-30 | 2019-10-22 | 杨顺平 | Jujube kernel water lily beans |
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| CN111227155A (en) * | 2020-03-31 | 2020-06-05 | 清远创春园食品生产有限公司 | Wild jujube seed and chrysanthemum solid beverage and preparation method thereof |
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Application publication date: 20161214 |