CN102526488B - Traditional Chinese medicine composition with pharynx-cleaning effect - Google Patents
Traditional Chinese medicine composition with pharynx-cleaning effect Download PDFInfo
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Abstract
The invention discloses a Chinese medicine composition with a pharynx-cleaning effect, which is prepared by raw materials including honeysuckle, platycodon grandiflorum, burdock, radix scrophulariae, Chinese olive, rehmannia, radix ophiopogonis, mentha haplocalyx, rhizoma polygonati and the like. The Chinese medicine composition with the pharynx-cleaning effect has the advantages of being good in curative effect, low in side effect and fast in effect.
Description
Technical field
The invention belongs to field of medicaments, be specifically related to a kind of Chinese medicine composition with function of moistening and cleaning throat, preparation and preparation method thereof.
Background technology
The sickness rate of pharyngolaryngitis is always high in China, and in rising trend.In city, the sickness rate of pharyngitis accounts for the 10%-20% of all disease of pharynx, and rural area is lower, accounts for 5.5% left and right.Be mainly in adult.In every day medical patient, pharyngolaryngitis has accounted for very large ratio.If pharyngolaryngitis pays no heed to or malpractice very easily forms chronic pharyngolaryngitis, even cancerate.
Pharyngolaryngitis is the inflammation of pharyngeal mucosa, submucous tissue, is often a part for upper respiratory tract infection.According to the length of the course of disease and the difference of pathological change character, be divided into acute pharyngitis, the large class of chronic pharyngitis two.Chronic pharyngitis is a kind of commonly encountered diseases, frequently-occurring disease clinically, in conventional Drug therapy, more obstinate, and outbreak repeatedly.
Traditional medicine thinks that chronic pharyngitis etiology and pathogenesis is often for internal organs are deficient, consumption impairment of YIN gas, hyperactivity of deficient fire causes in throat, or because acute pharyngitis due to wind-heat shows effect repeatedly, remaining evil delay, or dust, foul smell stimulate, hobby tobacco and wine are pungent, and impairment caused by overstrain excessively waits and causes, deficiency of lung-YIN is deficiency of body fluid, throat loses in moistening foster, and furthermore asthenic fire is followed through upper inflammation; Deficiency of the kidney yin, on the passages through which vital energy circulates of kidney, network is in lung, and deficiency of the kidney yin causes the also deficiency of YIN of lung, and hyperactivity of deficient fire causes sore throat then.In addition, in asthenic fire, steam, expectorant is burnt in Tianjin, venation numbness resistance in addition, and disorder of QI movement, causes stagnation of QI expectorant solidifying, phlegm-fire pent-up.Doctor trained in Western medicine it is generally acknowledged chronic pharyngitis because: 1. acute pharyngitis shows effect repeatedly; 2. upper respiratory tract chronic inflammatory disease stimulates, as sinusitis, and chronic tonsillitis etc.; 3. tobacco and wine are excessive, and dust, harmful gas etc. stimulate and happiness food irritable food; 4. occupational factor (teacher and chanteur) and physical factors; 5. systemic factor: anemia, dyspepsia, heart disease, chronic tracheitis, endocrine regulation etc.Current research to chronic pharyngitis shows: viral infection plays an important role in the morbidity of infective pharyngitis, it is reported that the recall rate of the pharyngeal virus of pharyngitis patient is 27%, is mainly Epstein-Barr virus and adenovirus.It is still one of important paathogenic factor of pharyngitis that antibacterial infects.Pathogenic bacterium are mainly Hemolytic streptococcus, secondly for staphylococcus aureus, influenza are bitten blood bacillus, mycoplasma pneumoniae etc.In addition, the symptom of the allergic inflammations such as the pharyngeal gargalesthesia paroxysmal of patients with chronic pharyngitis tool dry cough and allergen detect has positive rate up to 50%～60% report, all points out allergy factor to have important function in chronic pharyngitis morbidity.
Western medicine is to select antiviral agents mostly at present, as Moroxydine, diamantane (obsolete), interferon etc. or antibiotic and sulfa drugs are temporarily controlled the state of an illness, but it is harmful unhelpful to take too many antibiotic, because abuse of antibiotics may cause the imbalance of bottleneck throat normal flora.And can cause resistance reinforcement, immune function of human body goes down, and causes Relapse rate difficult.Chinese medicine all has good therapeutic effect to virus and antibacterial infection, and it take Chinese medical discrimination theory as basis, and the YIN nourishing of take increases liquid, nourishing the lung and kidney, removing heat-phlegm, the sore-throat relieving that wets one's whistle as the rule for the treatment of, can bring into play good therapeutic effect.
Chinese patent CN95110560.4 discloses a kind of Chinese medicine composition and processing method thereof for the treatment of chronic pharyngitis.By Radix Asparagi 10-25, Radix Ophiopogonis 5-15, Radix Glehniae 5-15, Rhizoma Polygonati Odorati 5-15, Flos Lonicerae 5-15, Radix Glycyrrhizae 1-10, Flos Chrysanthemi Indici 5-15, Pericarpium Citri Reticulatae 1-10, Semen Sterculiae Lychnophorae 10-25.Be applied to clinical, treatment YIN-deficiency type, phlegm-heat type, qi-asthenia type chnonic pharyngtis, total effective rate reaches 98%.
Chinese patent CN200610086678.1 provides a kind of acute/chronic pharyngitis, tonsillitic Chinese medicine composition and preparation method thereof for the treatment of.Said composition mainly by: Radix Scutellariae, FRUCTUS TERMINALIAE IMMATURUS, Radix Platycodonis, Caulis Bambusae In Taenia, Semen Sterculiae Lychnophorae, Exocarpium Citri Rubrum, Fructus Aurantii, Folium Mori, Rhizoma Cyperi (vinegar system), Fructus Perillae, Caulis Perillae, Lignum Aquilariae Resinatum, Mentholum etc. are made.This compositions directly or indirectly adds pharmaceutically acceptable excipient to make clinical acceptable dosage form through common process, as capsule, pill, tablet, buccal tablet, granule, oral liquid or injection etc., this compositions has relieving sore-throat by clearing away heat, the effect that the chest stuffiness relieving wets one's whistle.
Chinese patent CN201010503998.9 discloses a kind of Chinese medicine for the treatment of chronic pharyngitis, and its concrete proportioning is: 50 grams of Semen Sterculiae Lychnophoraes, 50 grams of Flos Chrysanthemis, 50 grams, Radix Glycyrrhizae, 50 grams of Calyx Seu Fructus Physaliss, 50 grams of Radix Scutellariaes, and the degree of accuracy of the dose of this medicine is each medicine ± 10%.The effect that this medical instrument has relieving sore-throat by clearing away heat, antiinflammatory to reduce phlegm, evident in efficacy, drug effect safety and stability, cure rate is high, without any side effects.
Summary of the invention
For the deficiency of current existence, the invention provides a kind of Chinese medicine composition with function of moistening and cleaning throat.Have good effect, side effect is low, rapid-action feature.
The Chinese drug-treated group of Chinese medicine composition of the present invention becomes:
Flos Lonicerae 120-300 Radix Platycodonis 150-375 Fructus Arctii 150-375 Radix Scrophulariae 180-450
Fructus Canarii 150-375 Radix Rehmanniae 150-375 150-375 Radix Ophiopogonis Herba Menthae 150-375
Rhizoma Polygonati 150-375
Preferably, the Chinese medicine of Chinese medicine composition of the present invention composition weight ratio is:
Flos Lonicerae 160-240 Radix Platycodonis 200-300 Fructus Arctii 200-300 Radix Scrophulariae 240-360
Fructus Canarii 200-300 Radix Rehmanniae 200-300 200-300 Radix Ophiopogonis Herba Menthae 200-300
Rhizoma Polygonati 200-300
Further preferred, the Chinese medicine of Chinese medicine composition of the present invention forms weight ratio and is:
Flos Lonicerae 200 Radix Platycodonis 250 Fructus Arctii 250 Radix Scrophulariaes 300
Fructus Canarii 250 Radix Rehmanniae Herba Menthaes 250 250 Radix Ophiopogonis 250
Rhizoma Polygonati 250
Flos Lonicerae is the alabastrum of the perennial half evergreen prehensile bejuco Radix Ophiopogonis Lonicera japonica Thund. of Caprifoliaceae, has heat-clearing and toxic substances removing, the effect of dispelling wind and heat pathogens.Li Shizhen (1518-1593 A.D.) claims in < < Compendium of Materia Medica > >: " all rheumatism gas, and all toxic swellings, carbuncle scabies, all malignant boil of Fructus Myricae rubrae.Heat radiation removing toxic substances.", modern pharmacology shows, this product has broad-spectrum antibacterial action, and the pathogenic bacterium such as staphylococcus aureus, dysentery bacterium are had to stronger inhibitory action, and the multiple pathogenic microorganisms such as leptospira, influenza virus and pathogenic moulds are also had to inhibitory action; There are obvious antiinflammatory and refrigeration function.
Radix Platycodonis is the root of campanulaceae herbaceos perennial Radix Platycodonis Platycodon grandiflorum (Jaoq.) A.DC..There is lung qi dispersing and eliminate the phlegm, sore-throat relieving, the effect of evacuation of pus.In < < pearl sac > >, claim: " treating throat pain; sharp lung qi; control nasal obstruction ", < < book on Chinese herbal medicine is looked for the truth in > > and is claimed: " Radix Platycodonis system opens the medicine of lung qi; can be all medicine ships; floating on carrying, and can draw hardship and rush down and complete lower dose.”。Modern pharmacology shows, this product energy reflexive increases organ secretion, dilution sputum and have stronger phlegm-dispelling functions; There is antitussive effect; There is antiinflammatory action; Can suppress gastric secretion and antiulcer; In addition also have the effects such as spasmolytic, analgesia, calmness, blood sugar lowering, blood fat reducing.
Fructus Arctii is the mature fruit of 2 years raw herbaceous plant Fructus Arctii Arctium lappa L. of Compositae.There is dispelling wind and heat pathogens, rash sore-throat relieving, the loose swollen effect of removing toxic substances.Li Shizhen (1518-1593 A.D.) claims in < < Compendium of Materia Medica > >: " speckle removing measles toxin ".Modern pharmacology shows, this product decoct has remarkable antibacterial action to Diplococcus pneumoniae, and has antipyretic, diuresis.
Radix Scrophulariae is the root of Scrophulariaceae herbaceos perennial Radix Scrophulariae Scrophularia ningpoensis Hemsl..There is the effect of clearing away heat and cooling blood, YIN nourishing removing toxic substances.Li Shizhen (1518-1593 A.D.) claims in < < Compendium of Materia Medica > >: " nourishing YIN to lower pathogenic fire is separated speckle poison, throat, diuresis stasis "; < < does not record in > > and claims: " lower water, stops excessive thirst, core under loose neck, carbuncle.”。Modern pharmacology shows, this product has blood vessel dilating, promotes local blood circulation and the effect that diminishes inflammation, and various skin fungus is had to inhibitory action; Bacillus pyocyaneus is also had to inhibitory action, in having in vitro and the effect of diphtheria toxin, diphtherotoxin.
Fructus Canarii is the dry mature fruit of olive subject plant Fructus Canarii albi Canarium album Raeusch..The effect of there is heat clearing away, sore-throat relieving, promote the production of body fluid, detoxifying.Modern pharmacology shows, this product has the effect of bacteria growing inhibiting.
Radix Rehmanniae is the root of Scrophulariaceae herbaceos perennial Radix Rehmanniae Rehmannia glutinosa Libosch.There is clearing away heat and cooling blood, the effect of YIN nourishing and the production of body fluid promoting.In < < pearl sac > >, claim: " the kidney invigorating water is Kidney-Yin for removing heat from blood, hemopoietic ".Modern pharmacology shows that this product has inhibitory action to the growth of multiple fungus.
Be the root of Liliaceae herbaceos perennial Ophiopogon Radix Ophiopogonis japonicus (L.f.) Ker-Gawl. Radix Ophiopogonis.There is nourishing YIN and moistening the lung, reinforcing stomach reg fluid, the effect of the relieving restlessness that clears away heart-fire.In < < Bencao Shiyi > >, claim: " remove heat in the heart, only dysphoria with smothery sensation.”。Modern pharmacology shows, this product can strengthen reticuloendothelial system phagocytic activity, and rising peripheral leukocytes improves immunologic function; Various bacteria is had to inhibitory action.
Herba Menthae is the stem and leaf of Labiatae herbaceos perennial Herba Menthae Mentha haplocalyx Briq..There is the effect of dispelling wind and heat pathogens, the clear sharp head, sore-throat relieving, rash, dispersing the stagnated live-QI to relieve the stagnation of QI.Li Shizhen (1518-1593 A.D.) claims in < < Compendium of Materia Medica > >: " all diseases of throat ability to speak are controlled scrofula, skin ulcer scabies, wind scabies urticaria." modern pharmacology shows; this product can be urged skin capillary vascular expansion; can promote respiratory tract glandular secretion and respiratory inflammation is had to therapeutical effect; herpes simplex virus, forest virus, mumps virus being had to inhibitory action, staphylococcus aureus, Staphylococcus albus, alpha streptococcus, group B streptococcus, micrococcus catarrhalis, enteritis coccus, shigella flexneri, anthrax bacillus, diphtheria corynebacterium, Bacillus typhi, bacillus pyocyaneus, escherichia coli etc. are had to bacteriostasis.
Rhizoma Polygonati is the rhizome of Liliaceae herbaceos perennial Rhizoma Polygonati Polygonatum sibiricum Red. Yunnan Rhizoma Polygonati P.kingianum Coll.et Hemsl or Polygonatum cyrtonema Hua P.cyrtonema Hua.The function with nourishing kidney lung moistening, invigorating the spleen and replenishing QI.In the just > > of < < book on Chinese herbal medicine, claim: " sweet in the mouth and thick greasy, quite class Radix Rehmanniae Preparata ... enriching blood nourishing YIN and supporting taste is its specialities." modern pharmacology shows that this product has inhibitory action to various bacteria and dermatophytes.
Prescription Main Basis theory of Chinese medical science, and with reference to modern pharmacology research data.We be take theory of Chinese medical science as guidance, the effective proved recipe summing up from long-term clinical practice, and the party's determined curative effect, rapid-action, without toxicity, pharyngolaryngitis is had to good therapeutical effect.In side, with Flos Lonicerae, Fructus Arctii, Herba Menthae, evacuate the wind heat of part of the body cavity above the diaphragm housing the heart and lungs women's head-ornaments, assistant is with the pyretic toxicity of the removing summer-heat throats such as Radix Scrophulariae, Radix Platycodonis, Fructus Canarii, is aided with the Radix Rehmanniae, Radix Ophiopogonis clearing away heat and nourishing YIN, and all medicines share, and play altogether heat-clearing and toxic substances removing, the effect of dispelling wind and eliminating swelling.
Chinese medicine composition of the present invention, can be called clinical acceptable various dosage forms by conventional preparation process preparation, as: the clinical conventional dosage forms such as granule, tablet, pill, capsule.
The preferred dosage form of Chinese medicine composition of the present invention is tablet.
The preparation technology of Chinese medicine composition of the present invention is:
Get the Chinese crude drug in Chinese medicine composition of the present invention, first according to above-mentioned prescription, measure Herba Menthae, within steam distillation 2-6 hour, extract volatile oil, the eight taste medical materials such as medicinal residues and all the other Flos Loniceraes, Radix Platycodonis, Rhizoma Polygonati, Fructus Arctii, Radix Scrophulariae, Fructus Canarii, Radix Rehmanniae, Rhizoma Polygonati and Radix Ophiopogonis, adding respectively 8-12 times of water gaging decocts, decoct each 0.5-3 hour 2-4 time; Merging filtrate, filters, and being concentrated into density is the extractum of 0.8-1.3 (60 ℃ of surveys), and extractum adds dextrin, steviosin and mannitol dry, according to common dosage forms technique, is prepared into clinical common formulations.
The preparation technology of Chinese medicine composition of the present invention is more preferably:
Get the Chinese crude drug in Chinese medicine composition of the present invention, first according to above-mentioned prescription, measure Herba Menthae, steam distillation extracts volatile oil for 3 hours, the eight taste medical materials such as medicinal residues and all the other Flos Loniceraes, Radix Platycodonis, Rhizoma Polygonati, Fructus Arctii, Radix Scrophulariae, Fructus Canarii, Radix Rehmanniae, Rhizoma Polygonati and Radix Ophiopogonis, adding respectively 10 times of water gagings decocts, decoct each 1.5 hours 2 times; Merging filtrate, filters, and being concentrated into density is the extractum of 1.10-1.20 (60 ℃ of surveys), and extractum adds dextrin, steviosin and mannitol dry, according to common dosage forms technique, is prepared into clinical common formulations.
Embodiment
Following examples, for better setting forth the present invention, only limit to following examples but should not be construed as the present invention.
Embodiment 1
Flos Lonicerae 300 Radix Platycodonis 150 Fructus Arctii 150 Radix Scrophulariaes 450
Fructus Canarii 375 Radix Rehmanniae Herba Menthaes 375 375 Radix Ophiopogonis 375
Rhizoma Polygonati 375
Get the Chinese crude drug in Chinese medicine composition of the present invention, first according to above-mentioned prescription, measure Herba Menthae, steam distillation extracts volatile oil for 3 hours, the eight taste medical materials such as medicinal residues and all the other Flos Loniceraes, Radix Platycodonis, Rhizoma Polygonati, Fructus Arctii, Radix Scrophulariae, Fructus Canarii, Radix Rehmanniae, Rhizoma Polygonati and Radix Ophiopogonis, adding respectively 10 times of water gagings decocts, decoct each 1 hour 2 times; Merging filtrate, filters, and being concentrated into density is the extractum of 1.10-1.15 (60 ℃ of surveys), and extractum adds dextrin, steviosin and mannitol dry, granulation, and packing, obtains.
Embodiment 2
Flos Lonicerae 120 Radix Platycodonis 375 Fructus Arctii 375 Radix Scrophulariaes 180
Fructus Canarii 375 Radix Rehmanniae Herba Menthaes 375 375 Radix Ophiopogonis 375
Rhizoma Polygonati 375
Get the Chinese crude drug in Chinese medicine composition of the present invention, first according to above-mentioned prescription, measure Herba Menthae, steam distillation extracts volatile oil for 2 hours, the eight taste medical materials such as medicinal residues and all the other Flos Loniceraes, Radix Platycodonis, Rhizoma Polygonati, Fructus Arctii, Radix Scrophulariae, Fructus Canarii, Radix Rehmanniae, Rhizoma Polygonati and Radix Ophiopogonis, adding respectively 12 times of water gagings decocts, decoct each 0.5 hour 4 times; Merging filtrate, filters, and being concentrated into density is the extractum of 1.15-1.25 (60 ℃ of surveys), and extractum adds dextrin, steviosin and mannitol dry, pulverize, capsule charge, and packing, obtains.
Embodiment 3
Flos Lonicerae 300 Radix Platycodonis 375 Fructus Arctii 375 Radix Scrophulariaes 450
Fructus Canarii 375 Radix Rehmanniae Herba Menthaes 150 150 Radix Ophiopogonis 375
Rhizoma Polygonati 375
Get the Chinese crude drug in Chinese medicine composition of the present invention, first according to above-mentioned prescription, measure Herba Menthae, steam distillation extracts volatile oil for 6 hours, the eight taste medical materials such as medicinal residues and all the other Flos Loniceraes, Radix Platycodonis, Rhizoma Polygonati, Fructus Arctii, Radix Scrophulariae, Fructus Canarii, Radix Rehmanniae, Rhizoma Polygonati and Radix Ophiopogonis, adding respectively 8 times of water gagings decocts, decoct each 3 hours 2 times; Merging filtrate, filters, and being concentrated into density is the extractum of 1.2-1.3 (60 ℃ of surveys), and extractum adds dextrin, steviosin and mannitol dry, pulverize, tabletting, and packing, obtains.
Embodiment 4
Flos Lonicerae 300 Radix Platycodonis 375 Fructus Arctii 375 Radix Scrophulariaes 450
Fructus Canarii 150 Radix Rehmanniae Herba Menthaes 375 375 Radix Ophiopogonis 150
Rhizoma Polygonati 375
Get the Chinese crude drug in Chinese medicine composition of the present invention, first according to above-mentioned prescription, measure Herba Menthae, steam distillation extracts volatile oil for 4 hours, the eight taste medical materials such as medicinal residues and all the other Flos Loniceraes, Radix Platycodonis, Rhizoma Polygonati, Fructus Arctii, Radix Scrophulariae, Fructus Canarii, Radix Rehmanniae, Rhizoma Polygonati and Radix Ophiopogonis, adding respectively 9 times of water gagings decocts, decoct each 1 hour 3 times; Merging filtrate, filters, and being concentrated into density is the extractum of 0.8-1.1 (60 ℃ of surveys), and extractum adds dextrin, steviosin and mannitol dry, pill, and packing, obtains.
Embodiment 5
Flos Lonicerae 300 Radix Platycodonis 375 Fructus Arctii 375 Radix Scrophulariaes 450
Fructus Canarii 375 Radix Rehmanniae Herba Menthaes 375 375 Radix Ophiopogonis 375
Rhizoma Polygonati 150
Get the Chinese crude drug in Chinese medicine composition of the present invention, first according to above-mentioned prescription, measure Herba Menthae, steam distillation extracts volatile oil for 5 hours, the eight taste medical materials such as medicinal residues and all the other Flos Loniceraes, Radix Platycodonis, Rhizoma Polygonati, Fructus Arctii, Radix Scrophulariae, Fructus Canarii, Radix Rehmanniae, Rhizoma Polygonati and Radix Ophiopogonis, adding respectively 11 times of water gagings decocts, decoct each 1.5 hours 3 times; Merging filtrate, filters, and being concentrated into density is the extractum of 1.05-1.2 (60 ℃ of surveys), and extractum adds dextrin, steviosin and mannitol dry, and packing, obtains powder.
Embodiment 6
Flos Lonicerae 200 Radix Platycodonis 250 Fructus Arctii 250 Radix Scrophulariaes 300
Fructus Canarii 250 Radix Rehmanniae Herba Menthaes 250 250 Radix Ophiopogonis 250
Rhizoma Polygonati 250
Get the Chinese crude drug in Chinese medicine composition of the present invention, first according to above-mentioned prescription, measure Herba Menthae, steam distillation extracts volatile oil for 3 hours, the eight taste medical materials such as medicinal residues and all the other Flos Loniceraes, Radix Platycodonis, Rhizoma Polygonati, Fructus Arctii, Radix Scrophulariae, Fructus Canarii, Radix Rehmanniae, Rhizoma Polygonati and Radix Ophiopogonis, adding respectively 10 times of water gagings decocts, decoct each 2 hours 2 times; Merging filtrate, filters, and being concentrated into density is the extractum of 1.1-1.2 (60 ℃ of surveys), and extractum adds dextrin, steviosin and mannitol dry, according to common dosage forms technique, is prepared into clinical common formulations.
Embodiment 7
Flos Lonicerae 160 Radix Platycodonis 200 Fructus Arctii 300 Radix Scrophulariaes 360
Fructus Canarii 300 Radix Rehmanniae Herba Menthaes 300 200 Radix Ophiopogonis 300
Rhizoma Polygonati 300
Get the Chinese crude drug in Chinese medicine composition of the present invention, first according to above-mentioned prescription, measure Herba Menthae, steam distillation extracts volatile oil for 4 hours, the eight taste medical materials such as medicinal residues and all the other Flos Loniceraes, Radix Platycodonis, Rhizoma Polygonati, Fructus Arctii, Radix Scrophulariae, Fructus Canarii, Radix Rehmanniae, Rhizoma Polygonati and Radix Ophiopogonis, adding respectively 10 times of water gagings decocts, decoct each 1 hour 3 times; Merging filtrate, filters, and being concentrated into density is the extractum of 1.15-1.25 (60 ℃ of surveys), and extractum adds dextrin, steviosin and mannitol dry, the step pelletize of spraying, and packing, obtains.
Embodiment 8
Flos Lonicerae 240 Radix Platycodonis 300 Fructus Arctii 200 Radix Scrophulariaes 240
Fructus Canarii 300 Radix Rehmanniae Herba Menthaes 300 300 Radix Ophiopogonis 200
Rhizoma Polygonati 300
Get the Chinese crude drug in Chinese medicine composition of the present invention, first according to above-mentioned prescription, measure Herba Menthae, steam distillation extracts volatile oil for 3 hours, the eight taste medical materials such as medicinal residues and all the other Flos Loniceraes, Radix Platycodonis, Rhizoma Polygonati, Fructus Arctii, Radix Scrophulariae, Fructus Canarii, Radix Rehmanniae, Rhizoma Polygonati and Radix Ophiopogonis, adding respectively 9 times of water gagings decocts, decoct each 2 hours 2 times; Merging filtrate, filters, and being concentrated into density is the extractum of 1.10-1.20 (60 ℃ of surveys), and extractum adds dextrin, steviosin and mannitol dry, according to common dosage forms technique, is prepared into clinical common formulations.
Embodiment 9
Flos Lonicerae 240 Radix Platycodonis 300 Fructus Arctii 300 Radix Scrophulariaes 360
Fructus Canarii 200 Radix Rehmanniae Herba Menthaes 200 300 Radix Ophiopogonis 300
Rhizoma Polygonati 200
Get the Chinese crude drug in Chinese medicine composition of the present invention, first according to above-mentioned prescription, measure Herba Menthae, steam distillation extracts volatile oil for 4 hours, the eight taste medical materials such as medicinal residues and all the other Flos Loniceraes, Radix Platycodonis, Rhizoma Polygonati, Fructus Arctii, Radix Scrophulariae, Fructus Canarii, Radix Rehmanniae, Rhizoma Polygonati and Radix Ophiopogonis, adding respectively 11 times of water gagings decocts, decoct each 1 hour 2 times; Merging filtrate, filters, and being concentrated into density is the extractum of 1.15-1.25 (60 ℃ of surveys), and extractum adds dextrin, steviosin and mannitol dry, a step pelletize, and tabletting, packing, obtains.
Embodiment 10 pharmacodynamic experiments
Medicine xylol of the present invention causes the impact of Mice Auricle inflammatory swelling
1, medicine and reagent
The extractum of the arbitrary acquisition of embodiment 1-7 is made into desired concn with distilled water before use, is thick solution; Dimethylbenzene ，Zhong Sheng Chemical Co., Ltd.; Prednisone acetate tablets, Henan Lihua Pharmaceutical Co., Ltd.
2, animal
Kunming mouse, Shandong University's Experimental Animal Center
3, method
Get 60 of the male mices of 20 ± 2 grams of body weight, be divided at random 5 groups: normal saline, prednisolone acetate 0.008g/kg, medicine 7.5g of the present invention, 15g, 30g crude drug/kg, each organizes continuous gastric infusion three days, within the 4th day, gastric infusion is after 30 minutes, dimethylbenzene is applied to two sides, mice left ear front and back, every 0.1ml, after 4 hours, put to death mice, with 9mm card punch, in left and right auricle same area, punch, both sides auricle is weighed respectively, usings swelling rate as swelling level index, by formula, calculates, difference between comparative drug group and matched group, the results are shown in following table.
Table 1 medicine xylol of the present invention causes the impact of Mice Auricle inflammatory swelling
* p < 0.05, * * p < 0.01 and the comparison of normal saline group.
Embodiment 11 pharmacodynamic experiments
The impact of medicine of the present invention on rat carrageenan pedal swelling
1, medicine and reagent
The extractum of the arbitrary acquisition of embodiment 1-7 is made into desired concn with distilled water before use, is thick solution; Dimethylbenzene ，Zhong Sheng Chemical Co., Ltd.; Prednisone acetate tablets, Henan Lihua Pharmaceutical Co., Ltd.
2, animal
Wistar rat, Shandong University's Experimental Animal Center
3, method
50 of male Wistar rats are selected in experiment, and body weight 200～240g, is divided into 5 groups every group 10 at random, is high, medium and low three the dosage groups of prednisolone acetate group, normal saline matched group and medicine of the present invention.Each group is subject to 1 times/day of reagent, continuous 7 days to corresponding content.After last administration, first with volumetric method, measure right back sufficient sole of the foot volume, and mark.Again in right back sufficient plantar subcutaneous injection 1% carrageenin 0.1ml, and in mark, with same method, survey sufficient sole of the foot volume in 1,3,5 hour after injection, deduct administration front volume and be sufficient pawl swelling, result is learned after processing by statistics, the results are shown in following table.
The impact of table 2 medicine of the present invention on rat carrageenan pedal swelling
With model control group comparison, * P < 0.05, * * P < 0.01.
Embodiment 11 pharmacodynamic experiments
Medicine of the present invention is on the swollen impact of rat rat granuloma
1, medicine and reagent
The extractum of the arbitrary acquisition of embodiment 1-7 is made into desired concn with distilled water before use, is thick solution; Prednisone acetate tablets, Henan Lihua Pharmaceutical Co., Ltd.
2, animal
SD rat, Shandong University's Experimental Animal Center
3, method
Get 60 of the male rats of 200 ± 20 grams of body weight, under ether light anaesthesia aseptic condition, make abdominal incision, by the cotton balls (about 50mg) after drying in the baking oven of 50 degrees Celsius of autoclavings of having weighed, implant rat both sides axillary region subcutaneous.Be divided at random 5 groups: normal saline, prednisolone acetate 0.028g/kg, medicine of the present invention 0.607,1.215,2.43g crude drug/kg, each organizes continuous gastric infusion seven days, within the 8th day, rat is put to death, peel off and take out granulation tissue.In the drying in oven of 60 degrees Celsius, deduct raw cotton ball weight, be granuloma net weight.Respectively organize granuloma weight.And calculate suppression ratio.
Table 3 medicine of the present invention is on the swollen impact of rat granuloma
* p < 0.05, * * p < 0.01 and the comparison of normal saline group.
Claims (4)
1. a Chinese medicine composition with function of moistening and cleaning throat, is characterized in that Chinese crude drug forms weight ratio and is:
Flos Lonicerae 160-240 Radix Platycodonis 200-300 Fructus Arctii 200-300 Radix Scrophulariae 240-360
Fructus Canarii 200-300 Radix Rehmanniae 200-300 200-300 Radix Ophiopogonis Herba Menthae 200-300
Rhizoma Polygonati 200-300.
2. Chinese medicine composition as claimed in claim 1, is characterized in that Chinese crude drug forms weight ratio and is:
Flos Lonicerae 200 Radix Platycodonis 250 Fructus Arctii 250 Radix Scrophulariaes 300
Fructus Canarii 250 Radix Rehmanniae Herba Menthaes 250 250 Radix Ophiopogonis 250
Rhizoma Polygonati 250.
3. Chinese medicine composition claimed in claim 1, its preparation technology is:
Get the Chinese crude drug in Chinese medicine composition of the present invention, first according to above-mentioned prescription, measure Herba Menthae, within steam distillation 2-6 hour, extract volatile oil, the eight taste medical materials such as medicinal residues and all the other Flos Loniceraes, Radix Platycodonis, Rhizoma Polygonati, Fructus Arctii, Radix Scrophulariae, Fructus Canarii, Radix Rehmanniae and Radix Ophiopogonis, adding respectively 8-12 times of water gaging decocts, decoct each 0.5-3 hour 2-4 time; Merging filtrate, filters, and is concentrated into the extractum that 60 ℃ of surveys of density are 0.8-1.3, and extractum adds dextrin, steviosin and mannitol dry, according to common dosage forms technique, is prepared into clinical common formulations.
4. Chinese medicine composition as claimed in claim 2, its preparation technology is:
Get the Chinese crude drug in Chinese medicine composition of the present invention, first according to above-mentioned prescription, measure Herba Menthae, steam distillation extracts volatile oil for 3 hours, the eight taste medical materials such as medicinal residues and all the other Flos Loniceraes, Radix Platycodonis, Rhizoma Polygonati, Fructus Arctii, Radix Scrophulariae, Fructus Canarii, Radix Rehmanniae and Radix Ophiopogonis, adding respectively 10 times of water gagings decocts, decoct each 1.5 hours 2 times; Merging filtrate, filters, and is concentrated into the extractum that 60 ℃ of surveys of density are 1.10-1.20, and extractum adds dextrin, steviosin and mannitol dry, according to common dosage forms technique, is prepared into clinical common formulations.
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| CN106234907A (en) * | 2016-09-13 | 2016-12-21 | 西安澳邦生物制品有限公司 | A kind of solid beverage for moistening and cleaning throat profit throat and preparation method thereof |
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