CN101757430A - Medicament for treating pharyngolaryngeal diseases - Google Patents
Medicament for treating pharyngolaryngeal diseases Download PDFInfo
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- CN101757430A CN101757430A CN200910217852A CN200910217852A CN101757430A CN 101757430 A CN101757430 A CN 101757430A CN 200910217852 A CN200910217852 A CN 200910217852A CN 200910217852 A CN200910217852 A CN 200910217852A CN 101757430 A CN101757430 A CN 101757430A
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Abstract
The invention relates to a medicament for treating pharyngolaryngeal diseases, belonging to the field of medicines. The invention aims at providing a medicament of a traditional Chinese medicine formula for effectively treating pharyngolaryngeal diseases. The effective components of the medicament is prepared from the following raw materials of honeysuckle, sterculia lychnophora, radix ophiopogonis, radix scrophulariae, Chinese olive, dark plum, platycodon grandiflorum, licorice root, green tea, peppermint oil and beta-CD. The invention has the efficacies of nourishing yin, clearing away the lung-heat, relieving sore throat and detoxifying. Accordingly, a formula is prepared by the honeysuckle, the sterculia lychnophora, the radix ophiopogonis, the radix scrophulariae, the Chinese olive, the dark plum, the platycodon grandiflorum, the licorice root, the green tea, the peppermint and the like on the basis of a traditional Chinese medicine theory and clinical practices. Because the invention has the efficacies of soothing the lung and the stomach, clearing away the heat and dispelling the fire, detumescence and dispersing toxicity, nourishing yin and moistening the throat, relieving sore throat and recovering voice, and has the advantages of both internal administration and external treatment, when being taken, the medicament has the effect of external treatment, and after taken down, the medicament has the effect of internal administration, which facilitates patients and has better health care effect and auxiliary curative effect; therefore, the medicament is named as compound throat-clearing tea bag by combining the efficacy and the formula according to a traditional Chinese medicine naming convention.
Description
Technical field:
The invention belongs to field of medicaments.
Background technology:
Throat is department's diet, and row is breathed, soniferous organ, on connect the oral cavity, following logical lung stomach is will weighing of channel course.Larynx is a lung system, swallows to be stomach system, and throat is particularly close by meridians and lung stomach relation." interior warp " gone up and said: " the epiglottis person, the door of sound sound is also; The lip person, the fan of sound sound is also; The tongue person, the machine of sound sound is also; Outstanding harmony person, the pass of sound sound is also ".So for seeing, endogenous cause of ill is then based on phlegm-fire, hyperactivity of YANG due to deficiency of YIN more with wind heat for exopathogenic factors such as the general aphonia of clinical findings, the Sha of neighing, laryngopharynx swelling and pain.So in determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs, whenever stress catharsis lung stomach, clearing throat is the rule of treatment.
Acute and chronic pharyngitis disease is common clinical, frequently-occurring disease, also is the occupation disease of being engaged in some Job personnel, as: aspects such as literature and art, education, broadcast, sale.In addition, some physics or chemical factor also can injure throat, and be bigger to people's physical and mental health harm.Therefore, be badly in need of a kind of protection throat of development, prevent the throat disease, and can improve the resistance against diseases of body, improve function, the Chinese medicine health-care medicine of relief of symptoms.
Development along with pharmaceutics and related discipline, the research tendency of Chinese medicine drug-supplying system is to be starting point to meet clinical needs, with the Chinese medical theory is guidance, develop towards the novel form direction efficient, long-acting, that toxicity is little and consumption is few, the curative effect of medicine, safety, stability and dosage form and preparation technique have confidential relation.
(1) acute pharyngitis
1. wind-cold type: pharyngalgia, mouthful thirsty, aversion to cold does not generate heat or slight fever, the pharyngeal mucous membrane edema, not congested or mild hyperaemia, body of the tongue is not red, white and thin fur, floating and tense pulse.
2. anemopyretic: pharyngalgia, mouthful little thirsty, heating, slight chill, pharyngeal mild hyperaemia, edema, tongue tip side of red, white and thin fur, floating and rapid pulse.
3. lung excess of the stomach pattern of fever: pharyngalgia is acute, and repeatedly thirsty, cough with ropy sputum is thick, heating, it is dried partially to defecate, yellowish or reddish urine, pharyngeal congestion more very,, red tongue, yellow and thin fur, rapid pulse is strong.
(2) chronic pharyngitis
1. YIN-deficiency type: throat is done painful, and is scorching hot, and sx after the polylogia is choked and coughed no expectorant, or a small amount of sticking expectorant is arranged, again and again ask drink, the drink amount is few, and symptom is obvious when reaching dusk in the afternoon, pharyngeal congestion kermesinus, mucosa drying, atrophy, or lymph foilicie hyperplasia is arranged, red tongue, thin fur is few, the red number of arteries and veins.
2. qi-deficiency type: dry laryngopharynx, but desire drink, cough has expectorant easily to cough up, fear of cold at ordinary times, easy catching a cold, refreshing tired weak, voice are humble, and big loose stool is thin, and check and see pharyngeal congestion not very, retropharyneal folliculosis, tongue fur is white and moist, thready and weak pulse.
3. phlegm-heat type: have sore throat, scorching hot, drying, diseases such as foreign body sensation are because of suffering from cold fatigue, increase the weight of after the polylogia, cough with ropy sputum is thick, and thirst and liking drink is checked and seen that pharyngeal mucous membrane hyperemia is plump rear wall lymph follicle of peony and funiculus lateralis enlargement, there is yellow-white secretions to adhere to, red tongue, greasy fur, rolling pulse.
Summary of the invention:
The purpose of this invention is to provide the medicine that a kind of Chinese medicinal formulae is used for effectively treating laryngopharyngeal diseases.
The present invention makes the raw materials of effective components weight portion and consists of:
0.5～2 Radix Ophiopogonis 1～5 of Flos Lonicerae 1～5 Semen Sterculiae Lychnophorae
Radix Scrophulariae 1～5 Fructus Canarii 1～5 Fructus Mume 1～5
Radix Platycodonis 1～5 Radix Glycyrrhizae 1～4 green tea 0.5～2
Oleum menthae 0.05～0.2 β-CD 0.5～2
The present invention makes raw materials of effective components weight portion best group to be become:
0.833 Radix Ophiopogonis 2.5 of Flos Lonicerae 2.5 Semen Sterculiae Lychnophoraes
Radix Scrophulariae 2.5 Fructus Canariis 2.5 Fructus Mumes 2.5
Radix Platycodonis 2.5 Radix Glycyrrhizaes 1.67 green tea 0.833
Oleum menthae 0.083 β-CD 0.833
The present invention has the YIN nourishing lung heat clearing, the effect of liyan jiedu.On this basis, according to Chinese medicine theory and clinical practice, form prescription with Flos Lonicerae, Semen Sterculiae Lychnophorae, Radix Ophiopogonis, Radix Scrophulariae, Fructus Canarii, Fructus Mume, green tea, Herba Menthae, Radix Platycodonis etc., because this product has catharsis lung stomach, the heat clearing away fire of dispelling, detumescence is loose malicious, YIN nourishing wets one's whistle, the effect of sore-throat relieving echo, this dosage form are taken in the advantage of innerwear outer treatment concurrently, play the effect of external treatment when drinking, merit for oral administration is arranged again after swallowing, both made things convenient for the patient, better health care and auxiliary curative effect had been arranged again, so add dosage form called after compound recipe moistening and cleaning throat teabag by effect according to the Chinese medicine nomenclature principle.
The inflammatory reaction that multiple proinflammatory agent is caused has the obvious suppression effect.Obviously suppress inflammatory reaction and the allergic inflammation that the anaphylaxis medium causes, and with the common pathogenic bacterium of upper respiratory tract the obvious suppression effect is arranged multiple.Work and be better than some similar medicines.This product disease sites that in drinking process, can go directly, the local drug concentration height absorbs by oral cavity, pharyngolaryngeal mucosa, and whole machine body is also had catharsis lung stomach, and the merit of promoting the production of body fluid and having one's ideas straightened out strengthens throat-benefiting, the effect of dispersing swelling and dissipating binds again feeding back in the part.Clinical observation result shows that this product is more obvious to change the bottleneck throat cardinal symptom especially.Rapid-action, effect is strong, and has no side effect, and is the voice worker, the health-care good product of the smoker and the person's indispensability of suffering from the laryngopharyngitis for a long time.
The specific embodiment:
The present invention makes the raw materials of effective components weight portion and consists of:
0.5～2 Radix Ophiopogonis 1～5 of Flos Lonicerae 1～5 Semen Sterculiae Lychnophorae
Radix Scrophulariae 1～5 Fructus Canarii 1～5 Fructus Mume 1～5
Radix Platycodonis 1～5 Radix Glycyrrhizae 1～4 green tea 0.5～2
Oleum menthae 0.05～0.2 β-CD (cyclodextrin) 0.5～2
The present invention makes raw materials of effective components weight portion best group to be become:
0.833 Radix Ophiopogonis 2.5 of Flos Lonicerae 2.5 Semen Sterculiae Lychnophoraes
Radix Scrophulariae 2.5 Fructus Canariis 2.5 Fructus Mumes 2.5
Radix Platycodonis 2.5 Radix Glycyrrhizaes 1.67 green tea 0.833
Oleum menthae 0.083 β-CD (cyclodextrin) 0.833
Function: catharsis lung stomach, heat clearing away dispel fire, dispersing swelling and dissipating binds, promote the production of body fluid have one's ideas straightened out, the sore-throat relieving echo, YIN nourishing wets one's whistle.
Cure mainly: laryngopharynx swelling and pain, acute and chronic pharyngitis, tonsillitis, periodontitis, diseases such as stomatitis.
Preparation technology of the present invention is:
Flos Lonicerae, Semen Sterculiae Lychnophorae, Radix Ophiopogonis, Radix Scrophulariae, Fructus Canarii, Fructus Mume, green tea, Oleum menthae, Radix Platycodonis, Radix Glycyrrhizae ten flavor medicines, Flos Lonicerae, Fructus Canarii, Radix Ophiopogonis, Semen Sterculiae Lychnophorae, Fructus Mume decoct with water secondary and (add 7 times of water gagings successively, decocting time 1 hour; Add 3 times of water gagings, decocting time 0.5 hour), filter, merging filtrate is condensed into clear paste (every milliliter is equivalent to contain crude drug 1.5g); Radix Platycodonis, Radix Scrophulariae, Radix Glycyrrhizae, green tea powder are broken into coarse powder; Get β-CD and add 2 times of water gagings, add Oleum menthae again, fully mill and mixed 15 minutes, get pastel, cold drying gets cellular thing, pulverizes the β-CD inclusion complex that promptly gets Oleum menthae.Inclusion complex evenly is mixed in the coarse powder of Radix Platycodonis, Radix Scrophulariae, Radix Glycyrrhizae, green tea four Chinese medicine, then, admixes in the above-mentioned clear paste, mixing is granulated, dry packing, that is, and every bag of 1g.
Embodiment 1:
The present invention makes the raw materials of effective components weight portion and consists of:
0.5 Radix Ophiopogonis 1 of Flos Lonicerae 1 Semen Sterculiae Lychnophorae
Radix Scrophulariae 1 Fructus Canarii 1 Fructus Mume 1
Radix Platycodonis 1 Radix Glycyrrhizae 1 green tea 0.5
Oleum menthae 0.05 β-CD 0.5
Preparation technology:
Flos Lonicerae, Semen Sterculiae Lychnophorae, Radix Ophiopogonis, Radix Scrophulariae, Fructus Canarii, Fructus Mume, green tea, Oleum menthae, Radix Platycodonis, Radix Glycyrrhizae ten flavor medicines, Flos Lonicerae, Fructus Canarii, Radix Ophiopogonis, Semen Sterculiae Lychnophorae, Fructus Mume decoct with water secondary and (add 7 times of water gagings successively, decocting time 1 hour; Add 3 times of water gagings, decocting time 0.5 hour), filter, merging filtrate is condensed into clear paste (every milliliter is equivalent to contain crude drug 1.5g); Radix Platycodonis, Radix Scrophulariae, Radix Glycyrrhizae, green tea powder are broken into coarse powder; Get β-CD and add 2 times of water gagings, add Oleum menthae again, fully mill and mixed 15 minutes, get pastel, cold drying gets cellular thing, pulverizes the β-CD inclusion complex that promptly gets Oleum menthae.Inclusion complex evenly is mixed in the coarse powder of Radix Platycodonis, Radix Scrophulariae, Radix Glycyrrhizae, green tea four Chinese medicine, then, admixes in the above-mentioned clear paste, mixing is granulated, dry packing, that is, and every bag of 1g.
Embodiment 2:
0.833 Radix Ophiopogonis 2.5 of Flos Lonicerae 2.5 Semen Sterculiae Lychnophoraes
Radix Scrophulariae 2.5 Fructus Canariis 2.5 Fructus Mumes 2.5
Radix Platycodonis 2.5 Radix Glycyrrhizaes 1.67 green tea 0.833
Oleum menthae 0.083 β-CD (cyclodextrin) 0.833
Preparation technology is identical with embodiment 1.
Embodiment 3:
2 Radix Ophiopogonis 5 of Flos Lonicerae 5 Semen Sterculiae Lychnophoraes
Radix Scrophulariae 5 Fructus Canariis 5 Fructus Mumes 5
Radix Platycodonis 5 Radix Glycyrrhizaes 4 green tea 2
Oleum menthae 0.2 β-CD (cyclodextrin) 2
Preparation technology is identical with embodiment 1.
The present invention is monarch with the Flos Lonicerae, and the heat of energy clearing heat in QI system blood is separated the poison in the blood.With Semen Sterculiae Lychnophorae, Radix Ophiopogonis, Radix Scrophulariae, Fructus Canarii, Fructus Mume is minister, and Flos Lonicerae is joined Semen Sterculiae Lychnophorae, controls Radix Ophiopogonis burning hot scorching and cause pharyngeal swelling sore throat person; Radix Scrophulariae energy clearing throat is swollen, rushes down the fire of unrooted; Fructus Canarii and Fructus Mume match to wet one's whistle and grow dryly, let out fiery moistening and cleaning throat.The laryngopharynx swelling and pain of the auxilliary Flos Lonicerae speciality of five ministerial drugs due to the catharsis lung gastric heat poison Yong Sai.Assistant is with green tea, and Oleum menthae two medicines can be helped and be helped refresh oneself on the monarch-minister drug and throat is let out fast gas of lung stomach and sound clearly.Make with Radix Platycodonis, the disease of can going directly for the ships medicine carrying of all medicines is up position is equipped with Radix Glycyrrhizae, but coordinating the actions of various ingredients in a prescription again, all diseases of extensively treating throat dispute.
1. root herbs such as Radix Platycodonis, Radix Scrophulariae, Radix Glycyrrhizae are ground into fine powder, in the time of in admixing clear paste, are easy to absorb medicinal liquid than other class medical materials; Except that Oleum menthae, other all liquid medicine are fried in shallow oil into clear paste, have both kept former medicine characteristic, can reduce the patent medicine volume again, are easy to carry and take.
2. Oleum menthae because of the easily loss volatile oil that volatilizees, therefore, is made inclusion complex with Oleum menthae and beta-schardinger dextrin-in finished product preparation and storage process, avoids its loss.Finished product when drinking, still keeps strong Herba Menthae fragrance after long term store.
The inflammatory reaction that proinflammatory agents such as xylol of the present invention, Ovum Gallus domesticus album, carrageenin cause has the obvious suppression effect; Can obviously reduce increasing of mouse peritoneal capillary permeability.Obviously suppress the inflammatory reaction that anaphylaxis medium histamine causes.Allergic inflammation with immunologic mechanism participation is also had significantly; Inhibitory action.Its antiinflammatory action is better than FUFANG CAOSHANHU HANPIAN.Extracorporeal bacteria inhibitor test is the result show, teabag has tangible bacteriostasis to several with the common pathogenic bacterium of upper respiratory tract.In sum, several pharmacological actions of teabag are them
To the pharmacological basis of prevention, health care and the auxiliary treatment of throat, oral inflammation disease, and can improve the resistance against diseases of body, alleviate disease, improve function.
Clinical experiment:
[physical data]
One, sex and age:
Among the 60 routine patients, male's 27 examples account for 45%, and women's 33 examples account for 53%.Age reckling 5 years old, the maximum 80 years old.Mean age is 40.35 years old.
Two, the occupation and the course of disease:
Among the 60 routine patients, dialectical genus wind heat person 28 examples, wind and cold person 10 examples, deficiency of YIN person's 18 examples, hot person's 3 examples of expectorant, deficiency of vital energy person's 1 example; Acute pharyngitis 38 examples, chronic pharyngitis 22 examples.
Three, curative effect determinate standard:
Produce effects: 1 week disappeared with interior clinical symptoms and part sign with interior sx in 3 days after the medication, i.e. (+++) → (-) 1,3 of (++) → (+), or 5 of (+) → (-).
Effectively: 1 week disappeared with interior clinical symptoms and part sign with interior sx in 3 days after the medication, i.e. (+++) → (+) 2,2 of (++) → (+), or 3 of (+) → (-).
Invalid: no change person before and after the medication.
Usage: for drink, in each 1 generation, drink every day frequently with tea, and serveing on 7 days is 1 course of treatment.
[observed result]
One, 60 routine patient's total effectses see Table 1.
Table 1 60 routine patient's total effectses
By this its total effective rate of medicated tea control acute/chronic pharyngitis after as seen taking medicine in the table 1 is 88.33%.
Two, after 60 routine patient's medications to the influence of hemogram, see Table 2.
After table 2 60 routine patient's medications to the influence of Hb, RBC, WBC
As seen this medicated tea all has reduction trend to Hb, RBC, WBC in the blood after taking medicine in the table 2, but remarkable to lower WBC especially.
Three, after 60 routine patient's medications to the situation that influences of pharyngeal sign (swallowing red, pharyngeal swelling, tonsil enlargement etc.), see Table 3.
The take medicine influence of pharyngeal signs such as back, pharyngeal swelling red of table 3 60 routine patients to swallowing
As seen the pharyngeal sign disappearance rate such as red to swallowing behind the tea, pharyngeal swelling of taking medicine in the table 3 are 88.33%.
Four, 60 routine patients carry out laboratory examination to routine urinalysis before and after taking medicine, and have no significant change, and as seen this medicine is without any side effects to kidney.
Five, to the doing well,improving situation, see table 4 for details before and after moistening and cleaning throat echo tea is taken medicine.
Table 4 moistening and cleaning throat echo tea is taken medicine front and back to the doing well,improving situation
As seen improve all more obvious to acute and chronic pharyngitis cardinal symptom after taking medicine in the table 4.
Show that by 60 routine moistening and cleaning throat echo tea observed results it is 98.33% that this medicine is prevented and treated throat disease, its total effective rates such as acute and chronic pharyngitis.Especially think that to improve symptom obvious, and can be and reduce WBC in the blood as seen pharynx-clearing throat-benefiting is arranged, the effect of heat-clearing and toxic substances removing.And under observation not finding any toxic and side effects, we think that this medicine is for preventing and treating the best health care good medicine of acute/chronic pharyngitis.
Claims (2)
1. medicine for the treatment of laryngopharyngeal diseases, wherein make the raw materials of effective components weight portion and consist of:
0.5～2 Radix Ophiopogonis 1～5 of Flos Lonicerae 1～5 Semen Sterculiae Lychnophorae
Radix Scrophulariae 1～5 Fructus Canarii 1～5 Fructus Mume 1～5
Radix Platycodonis 1～5 Radix Glycyrrhizae 1～4 green tea 0.5～2
Oleum menthae 0.05～0.2 β-CD 0.5～2.
2. the medicine of treatment laryngopharyngeal diseases according to claim 1, wherein making raw materials of effective components weight portion best group becomes:
0.833 Radix Ophiopogonis 2.5 of Flos Lonicerae 2.5 Semen Sterculiae Lychnophoraes
Radix Scrophulariae 2.5 Fructus Canariis 2.5 Fructus Mumes 2.5
Radix Platycodonis 2.5 Radix Glycyrrhizaes 1.67 green tea 0.833
Oleum menthae 0.083 β-CD 0.833.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910217852A CN101757430A (en) | 2009-11-13 | 2009-11-13 | Medicament for treating pharyngolaryngeal diseases |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910217852A CN101757430A (en) | 2009-11-13 | 2009-11-13 | Medicament for treating pharyngolaryngeal diseases |
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| Publication Number | Publication Date |
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| CN101757430A true CN101757430A (en) | 2010-06-30 |
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| CN200910217852A Pending CN101757430A (en) | 2009-11-13 | 2009-11-13 | Medicament for treating pharyngolaryngeal diseases |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101961417A (en) * | 2010-11-16 | 2011-02-02 | 江西天施康中药股份有限公司 | Preparation method of tablet for curing laryngalgia |
| CN102177998A (en) * | 2011-03-29 | 2011-09-14 | 刘维祺 | Throat-clearing health-care tea |
| CN102526488A (en) * | 2012-03-23 | 2012-07-04 | 临沂大学 | Chinese medicine composition with pharynx-cleaning effect |
| CN103859376A (en) * | 2012-12-10 | 2014-06-18 | 天津红日药业股份有限公司 | Formula and preparation method of life cultivation and health preservation food helpful for clearing throat heat and soothing throat |
-
2009
- 2009-11-13 CN CN200910217852A patent/CN101757430A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101961417A (en) * | 2010-11-16 | 2011-02-02 | 江西天施康中药股份有限公司 | Preparation method of tablet for curing laryngalgia |
| CN101961417B (en) * | 2010-11-16 | 2011-10-05 | 江西天施康中药股份有限公司 | Preparation method of tablet for curing laryngalgia |
| CN102177998A (en) * | 2011-03-29 | 2011-09-14 | 刘维祺 | Throat-clearing health-care tea |
| CN102526488A (en) * | 2012-03-23 | 2012-07-04 | 临沂大学 | Chinese medicine composition with pharynx-cleaning effect |
| CN102526488B (en) * | 2012-03-23 | 2014-02-12 | 临沂大学 | Traditional Chinese medicine composition with pharynx-cleaning effect |
| CN103859376A (en) * | 2012-12-10 | 2014-06-18 | 天津红日药业股份有限公司 | Formula and preparation method of life cultivation and health preservation food helpful for clearing throat heat and soothing throat |
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Open date: 20100630 |