CN102028865A - Medicinal composition for relieving cough and reducing sputum and method for preparing same - Google Patents
Medicinal composition for relieving cough and reducing sputum and method for preparing same Download PDFInfo
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- CN102028865A CN102028865A CN2010105521562A CN201010552156A CN102028865A CN 102028865 A CN102028865 A CN 102028865A CN 2010105521562 A CN2010105521562 A CN 2010105521562A CN 201010552156 A CN201010552156 A CN 201010552156A CN 102028865 A CN102028865 A CN 102028865A
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Abstract
The invention relates to a medicinal composition for relieving cough and reducing sputum and a method for preparing the same. The medicinal composition is prepared from bulk pharmaceutical chemicals of rehmanniae, fritillaria, anemarrhena, scrophulariaceae, ophiopogonis, citrus aurantium, licorice and the like by applying the basic theory of the traditional Chinese medicine. The medicinal composition has the efficacy of nourishing yin to clear away the lung-heat as well as relieving cough and reducing sputum, can be used for treating various throat diseases, is clinically applied for many years and has remarkable curative effect.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, more specifically say so a kind ofly have nourishing YIN and clearing away lung-heat, preventing phlegm from forming and stopping coughing is used for the treatment of Chinese medicine composition of laryngopharyngeal diseases and preparation method thereof; Belong to medical technical field.
Background technology
Motherland's medical science thinks many because internal organs loss, deficiency of YIN Tianjin are few, cause throat discomfort by force on the asthenic fire, lose in moistening foster, for a long time it, drape over one's shoulders in the asthenic fire bright Tianjin of burning, and holds concurrently with depression of QI, catharsis is not smooth, coagulates and cause qi depression to blood stasis expectorant.The resistance of QI and blood phlegm-turbidity and blood stasis, spacious clear YANG failing to ascend, turbid YIN failing to descend. so that QI and blood week is capable not smooth. retardance air flue and passages through which vital energy circulates.So dry and astringent vexed expanding appears in throat, as the thing infraction, utters a sound or a word and coughs up endlessly, war proclamation setting forth the purpose of the expedition and enumerating the crimes of the enemy pain, xerostomia be the desire drink not, protracted course of disease, the pharyngolaryngeal cavity mucosa is dark red, rear wall, deletes Suo Zenghou, curtain pearl hypertrophy, and local vascular dilation reticulates, dimly red tongue or give birth to lean point, then because of drinking and eating irregularly, surfeit is pungent, has a liking for tobacco and wine, accumulated heat in the lung and stomach in addition.Last steaming throat, stagnation of QI-blood, turbid the condensing of expectorant and be primary disease controlled suitable regulating QI and promoting blood circulation to remove blood stasis, and YIN nourishing is supported liquid, freely throat.
Chronic pharyngitis belongs to Chinese medicine sore throat category, and this disease system is owing to be subjected to pessimal stimulation for a long time and have a liking for the pungent product of food tobacco and wine, and consumption impairing the lung kidney body fluid causes YIN fluid being insufficient, and hyperactivity of deficient fire follows through last steaming, and the smoked throat that burns forms.Total its pathogenesis of chronic pharyngitis is a YIN-deficiency of the lung and kidney, Jiu Shi and medicine of the present invention is established at this pathogenesis.The moon of Radix Rehmanniae, Radix Ophiopogonis, taste lung kidney in the side and heat clearing away, the cough-relieving of Bulbus Fritillariae Cirrhosae moistening the lung and resolving phlegm.Play the merit of nourishing YIN and clearing away lung-heat, preventing phlegm from forming and stopping coughing altogether.
Medicine of the present invention is to be that the medicine of main effect is formed with nourishing YIN and clearing away lung-heat, preventing phlegm from forming and stopping coughing, is primarily aimed at throat commonly used, normal smoking, normal acute and chronic pharyngitis such as drink, and the crowd of diseases such as acute tonsillitis or pharyngolaryngitis develops.
Curative effect of medication of the present invention is good, and the adaptation population is wide, therefore is necessary to develop this class Chinese medicine new product.
Summary of the invention
Purpose of the present invention just provides pharmaceutical composition of a kind of preventing phlegm from forming and stopping coughing and preparation method thereof, and this pharmaceutical composition has the effect of nourishing YIN and clearing away lung-heat, preventing phlegm from forming and stopping coughing, and clinical practice is in the various laryngopharyngeal diseasess of treatment.This pharmaceutical composition can be prepared into different dosage form at needs of patients in addition, is convenient to take, and is easy to carry.
For achieving the above object, the pharmaceutical composition of preventing phlegm from forming and stopping coughing provided by the invention is formed by the following raw medicaments in portion by weight processing and preparing:
Radix Rehmanniae 12-25 part Bulbus Fritillariae Cirrhosae 5-15 part Rhizoma Anemarrhenae 10-24 part Radix Scrophulariae 8-16 part
Radix Ophiopogonis 5-15 part Fructus Aurantii Immaturus 10-24 part Radix Glycyrrhizae 5-12 part.
Preferred plan is formed by the following raw medicaments in portion by weight processing and preparing:
12 parts of 15 portions of Radix Scrophulariaes of 10 parts of Rhizoma Anemarrhenaes of 18 parts of Bulbus Fritillariae Cirrhosaes of the Radix Rehmanniae
8 parts in 15 portions of Radix Glycyrrhizaes of 10 parts of Fructus Aurantii Immaturuss Radix Ophiopogonis.
The pharmaceutical composition of a kind of preventing phlegm from forming and stopping coughing of the present invention can be prepared into capsule, tablet, granule.
Described weight portion can be weight metering units such as gram, two, jin, kilogram, ton.
Pharmaceutical composition of the present invention can adopt respectively the distinguish the flavor of medical material of conventional method in will writing out a prescription to carry out compatibility in proportion, makes various clinical suitable dosage forms by existing preparation process, and the used medical material of respectively distinguishing the flavor of is the Chinese crude drug that commercially available process is up to the standards.
Preparation method of the present invention comprises the steps:
(1) it is standby to get above-mentioned each bulk drugs;
(2) get Bulbus Fritillariae Cirrhosae according to the percolation (Chinese Pharmacopoeia appendix I O) under fluid extract and the extractum item, make solvent with 65～85% ethanol, flood after 18 hours, with the speed of per minute 1～3ml percolation slowly, treat that soluble component filters out fully, collect the liquid of filtering, reclaim ethanol, obtain percolate, be condensed into relative density and be 1.10～1.20 extractum;
(3) get the Radix Rehmanniae, the Rhizoma Anemarrhenae, Radix Scrophulariae, Radix Ophiopogonis, Fructus Aurantii Immaturus, Radix Glycyrrhizae and add 4～6 times of water gagings and decoct 2～4 times, each 2～4 hours, filter, merging filtrate is condensed into the extractum that relative density is 1.10-1.20;
(4) with (2), (3) mixing, add appropriate amount of auxiliary materials such as granulations such as starch, dextrin, drying, granule or filled capsules or tabletting are made in sterilization, get final product.
The preferred version of preparation method of the present invention comprises the steps:
(1) it is standby to get above-mentioned each bulk drugs;
(2) get Bulbus Fritillariae Cirrhosae according to the percolation (Chinese Pharmacopoeia appendix I O) under fluid extract and the extractum item, make solvent with 75% ethanol, flood after 18 hours, with the speed of per minute 1～3ml percolation slowly, treat that soluble component filters out fully, collect the liquid of filtering, reclaim ethanol, obtain percolate, be condensed into relative density and be 1.15 extractum;
(3) get the Radix Rehmanniae, the Rhizoma Anemarrhenae, Radix Scrophulariae, Radix Ophiopogonis, Fructus Aurantii Immaturus, Radix Glycyrrhizae and add 5 times of water gagings and decoct 3 times, each 3 hours, filter, merging filtrate is condensed into relative density and is 1.15 extractum;
(4) with (2), (3) mixing, add appropriate amount of auxiliary materials such as granulations such as starch, dextrin, drying, granule or filled capsules or tabletting are made in sterilization, get final product.
Why the present invention selects for use above-mentioned medical material as raw material, is because they have following effect:
The Radix Rehmanniae: clearing away heat and cooling blood, yin nourishing is promoted the production of body fluid.Be used for calentura crimson tongue excessive thirst, interior-heat caused by deficiency of YIN, the hectic fever due to YIN-deficiency consumptive fever, interior-heat is quenched one's thirst, and spits blood, and epistaxis is sent out the speckle dermexanthesis.
Bulbus Fritillariae Cirrhosae: clearing heat and moistening lung, preventing phlegm from forming and stopping coughing.Be used for lung-heat type cough, the few expectorant of dry cough, deficiency of YIN chronic cough, sputum with blood.
The Rhizoma Anemarrhenae: clearing away heat-fire, promote the production of body fluid and moisturize.Be used for fever caused by exogenous pathogenic factors, the hyperpyrexia excessive thirst, lung-heat type cough, osteopyrexia and fever, interior-heat is quenched one's thirst, the dryness of the intestine constipation.
Radix Scrophulariae: removing heat from blood YIN nourishing, eliminating fire and detoxication.Be used for consumption of YIN caused by febrile disease, the crimson tongue excessive thirst, maculae caused by violent heat pathogen, constipation is hindered in Tianjin, hectic fever due to YIN-deficiency chronic cough, conjunctival congestion, pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus.
Radix Ophiopogonis: YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.Be used for dryness of the lung dry cough, the chronic consumptive disease cough, Tianjin wound is thirsty, vexed insomnia, interior-heat is quenched one's thirst, dryness of the intestine constipation, pharyngeal diphtheria.
Fructus Aurantii Immaturus: dispelling the stagnated QI removing food stagnancy, the diffusing painful abdominal mass of reducing phlegm.Be used for stopping in stagnant, the feeling of fullness distending pain, heavy behind the dysentery, constipation, the expectorant vapour lock thoracic obstruction that stagnates, blocked-up chest; Gastroptosis, proctoptosis, sub-official's prolapsus.
Radix Glycyrrhizae: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Be used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Pharmaceutical composition provided by the invention has the effect of nourishing YIN and clearing away lung-heat, preventing phlegm from forming and stopping coughing, is used for the treatment of various laryngopharyngeal diseasess.
For the curative effect of medicine of the present invention is described, the applicant observes at the case aspect this in certain hospital, and the result is as follows:
Man's 15 examples, women 29 examples; Minimum 18 years old of age, maximum 61 years old; The course of disease is the longest 4 years, and is the shortest 3 months; The whole body ordinary circumstance is good, mainly shows pharyngeally to do, itch, foreign body sensation, dry cough, suppress bloated, hypodynia.Hoarseness in various degree checks that pharyngeal mucosa hyperemia is kermesinus; Vasodilation, lymph foilicie hyperplasia, the lateral pharyngeal band plumpness, vocal cords are congested in various degree, but movable good, do not see neoplasms such as polyp, brief summary, red tongue, part patient's tongue is seen petechia.
Therapeutic Method: take 2 weeks of medicine of the present invention.
The result treats and cures 33 examples (75%), effective 11 examples (25%), total effective rate 100% in 44 examples.
Above result shows that to alleviating disease of pharynx, the relieving cough symptom reaches the effect for the treatment of various laryngopharyngeal diseasess to medicine of the present invention by this invention medicine of above-mentioned description of test.
The excellent results of pharmaceutical composition of the present invention and preparation method thereof is:
1. medicament of the present invention is made by pure Chinese medicine, does not contain chemical components, does not contain hormone, has no side effect, and treating both the exterior and interior reaches the effect of better nourishing YIN and clearing away lung-heat, preventing phlegm from forming and stopping coughing, better treats various laryngopharyngeal diseasess;
2. this medicament can be prepared into different dosage form at needs of patients, is convenient to take, and is easy to carry;
3. technology of the present invention is simple, has reduced production cost, has alleviated patient's financial burden.
The specific embodiment
Below with embodiment pharmaceutical composition of a kind of preventing phlegm from forming and stopping coughing of the present invention and preparation method thereof is further described; this will help the present invention and effect thereof are further understood; embodiment does not limit protection scope of the present invention, and its protection domain is decided by claim.
Embodiment 1
In the present embodiment used crude drug be Radix Rehmanniae 120g, Bulbus Fritillariae Cirrhosae 50g, Rhizoma Anemarrhenae 100g, Radix Scrophulariae 80g, Radix Ophiopogonis 50g, Fructus Aurantii Immaturus 100g, Radix Glycyrrhizae 50g.
Its preparation method is:
Get Bulbus Fritillariae Cirrhosae according to the percolation (Chinese Pharmacopoeia appendix I O) under fluid extract and the extractum item, make solvent with 65% ethanol, flood after 18 hours, with the speed of per minute 1ml percolation slowly, treat that soluble component filters out fully, collect the liquid of filtering, reclaim ethanol, obtain percolate, be condensed into relative density and be 1.10～1.20 extractum; Other gets the Radix Rehmanniae, the Rhizoma Anemarrhenae, Radix Scrophulariae, Radix Ophiopogonis, Fructus Aurantii Immaturus, Radix Glycyrrhizae and adds 4 times of water gagings and decoct 2 times, and each 2 hours, filter, merging filtrate is condensed into the extractum that relative density is 1.10-1.20; Merge above-mentioned two kinds of extractum, adding starch is an amount of, granulate, and drying, granule 400g is made in sterilization, gets final product.
Embodiment 2
In the present embodiment used crude drug be the Radix Rehmanniae 250, Bulbus Fritillariae Cirrhosae 150g, Rhizoma Anemarrhenae 240g, Radix Scrophulariae 160g, Radix Ophiopogonis 150g, Fructus Aurantii Immaturus 240g, Radix Glycyrrhizae 120g.
Its preparation method is:
Get Bulbus Fritillariae Cirrhosae according to the percolation (Chinese Pharmacopoeia appendix I O) under fluid extract and the extractum item, make solvent with 85% ethanol, flood after 18 hours, with the speed of per minute 3ml percolation slowly, treat that soluble component filters out fully, collect the liquid of filtering, reclaim ethanol, obtain percolate, be condensed into relative density and be 1.20 extractum; Other gets the Radix Rehmanniae, the Rhizoma Anemarrhenae, Radix Scrophulariae, Radix Ophiopogonis, Fructus Aurantii Immaturus, Radix Glycyrrhizae and adds 6 times of water gagings and decoct 4 times, and each 4 hours, filter, merging filtrate is condensed into relative density and is 1.20 extractum; Merge above-mentioned two kinds of extractum, add appropriate amount of starch, granulate, drying, granule is made in sterilization, filled capsules, 1000 of academic titles get final product.
Embodiment 3
In the present embodiment used crude drug be Radix Rehmanniae 180g, Bulbus Fritillariae Cirrhosae 100g, Rhizoma Anemarrhenae 150g, Radix Scrophulariae 120g, Radix Ophiopogonis 100g, Fructus Aurantii Immaturus 150g, Radix Glycyrrhizae 80g.
Its preparation method is:
Get Bulbus Fritillariae Cirrhosae according to the percolation (Chinese Pharmacopoeia appendix I O) under fluid extract and the extractum item, make solvent with 75% ethanol, flood after 18 hours, with the speed of per minute 2ml percolation slowly, treat that soluble component filters out fully, collect the liquid of filtering, reclaim ethanol, obtain percolate, be condensed into relative density and be 1.15 extractum; Other gets the Radix Rehmanniae, the Rhizoma Anemarrhenae, Radix Scrophulariae, Radix Ophiopogonis, Fructus Aurantii Immaturus, Radix Glycyrrhizae and adds 5 times of water gagings and decoct 3 times, and each 3 hours, filter, merging filtrate is condensed into relative density and is 1.15 extractum; Merge above-mentioned two kinds of extractum, mixing adds an amount of dextrin, granulate, and drying, the granule tabletting is made in sterilization, makes 1000, gets final product.
Claims (5)
1. the pharmaceutical composition of a preventing phlegm from forming and stopping coughing is characterized in that being formed by the following raw medicaments in portion by weight processing and preparing:
Radix Rehmanniae 12-25 part Bulbus Fritillariae Cirrhosae 5-15 part Rhizoma Anemarrhenae 10-24 part Radix Scrophulariae 8-16 part
Radix Ophiopogonis 5-15 part Fructus Aurantii Immaturus 10-24 part Radix Glycyrrhizae 5-12 part.
2. the pharmaceutical composition of a kind of preventing phlegm from forming and stopping coughing according to claim 1 is characterized in that being formed by the following raw medicaments in portion by weight processing and preparing:
12 parts of 15 portions of Radix Scrophulariaes of 10 parts of Rhizoma Anemarrhenaes of 18 parts of Bulbus Fritillariae Cirrhosaes of the Radix Rehmanniae
8 parts in 15 portions of Radix Glycyrrhizaes of 10 parts of Fructus Aurantii Immaturuss Radix Ophiopogonis.
3. according to the pharmaceutical composition of claim 1 or 2 one of them described a kind of preventing phlegm from forming and stopping coughing, it is characterized in that preparation is capsule, tablet, granule.
4. according to the preparation of drug combination method of claim 1 or 2 one of them described a kind of preventing phlegm from forming and stopping coughing, it is characterized in that comprising the steps:
(1) it is standby to get above-mentioned each bulk drugs;
(2) get Bulbus Fritillariae Cirrhosae according to the percolation (Chinese Pharmacopoeia appendix I O) under fluid extract and the extractum item, make solvent with 65～85% ethanol, flood after 18 hours, with the speed of per minute 1～3ml percolation slowly, treat that soluble component filters out fully, collect the liquid of filtering, reclaim ethanol, obtain percolate, be condensed into relative density and be 1.10～1.20 extractum;
(3) get the Radix Rehmanniae, the Rhizoma Anemarrhenae, Radix Scrophulariae, Radix Ophiopogonis, Fructus Aurantii Immaturus, Radix Glycyrrhizae and add 4～6 times of water gagings and decoct 2～4 times, each 2～4 hours, filter, merging filtrate is condensed into the extractum that relative density is 1.10-1.20;
(4) with (2), (3) mixing, add appropriate amount of auxiliary materials such as granulations such as starch, dextrin, drying, granule or filled capsules or tabletting are made in sterilization, get final product.
5. the preparation of drug combination method of a kind of preventing phlegm from forming and stopping coughing according to claim 4 is characterized in that comprising the steps:
(1) it is standby to get above-mentioned each bulk drugs;
(2) get Bulbus Fritillariae Cirrhosae according to the percolation (Chinese Pharmacopoeia appendix I O) under fluid extract and the extractum item, make solvent with 75% ethanol, flood after 18 hours, with the speed of per minute 1～3ml percolation slowly, treat that soluble component filters out fully, collect the liquid of filtering, reclaim ethanol, obtain percolate, be condensed into relative density and be 1.15 extractum;
(3) get the Radix Rehmanniae, the Rhizoma Anemarrhenae, Radix Scrophulariae, Radix Ophiopogonis, Fructus Aurantii Immaturus, Radix Glycyrrhizae and add 5 times of water gagings and decoct 3 times, each 3 hours, filter, merging filtrate is condensed into relative density and is 1.15 extractum;
(4) with (2), (3) mixing, add appropriate amount of auxiliary materials such as granulations such as starch, dextrin, drying, granule or filled capsules or tabletting are made in sterilization, get final product.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010105521562A CN102028865A (en) | 2010-11-22 | 2010-11-22 | Medicinal composition for relieving cough and reducing sputum and method for preparing same |
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| CN2010105521562A CN102028865A (en) | 2010-11-22 | 2010-11-22 | Medicinal composition for relieving cough and reducing sputum and method for preparing same |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526458A (en) * | 2012-01-31 | 2012-07-04 | 山东三九药业有限公司 | Chinese olive mixture for stopping cough and preparing method thereof |
| CN104984040A (en) * | 2015-07-01 | 2015-10-21 | 宋云飞 | Medicine for treating phthisic hemoptysis |
| CN106728838A (en) * | 2016-12-29 | 2017-05-31 | 中悦民安（北京）科技发展有限公司 | A kind of relieving cough and asthma Chinese medicine composition |
| CN107029159A (en) * | 2017-06-08 | 2017-08-11 | 湖南云从科技有限公司 | It is a kind of to treat oral liquid that throat swells and ache and preparation method thereof |
-
2010
- 2010-11-22 CN CN2010105521562A patent/CN102028865A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526458A (en) * | 2012-01-31 | 2012-07-04 | 山东三九药业有限公司 | Chinese olive mixture for stopping cough and preparing method thereof |
| CN102526458B (en) * | 2012-01-31 | 2014-03-12 | 华润三九（枣庄）药业有限公司 | Chinese olive mixture for stopping cough and preparing method thereof |
| CN104984040A (en) * | 2015-07-01 | 2015-10-21 | 宋云飞 | Medicine for treating phthisic hemoptysis |
| CN106728838A (en) * | 2016-12-29 | 2017-05-31 | 中悦民安（北京）科技发展有限公司 | A kind of relieving cough and asthma Chinese medicine composition |
| CN107029159A (en) * | 2017-06-08 | 2017-08-11 | 湖南云从科技有限公司 | It is a kind of to treat oral liquid that throat swells and ache and preparation method thereof |
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Application publication date: 20110427 |