CN104984040A

CN104984040A - Medicine for treating phthisic hemoptysis

Info

Publication number: CN104984040A
Application number: CN201510377138.8A
Authority: CN
Inventors: 宋云飞
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-07-01
Filing date: 2015-07-01
Publication date: 2015-10-21

Abstract

The invention relates to a medicine for treating phthisic hemoptysis. The medicine is prepared from the following crude drugs in weight proportion: 9 parts of radix ophiopogonis, 6 parts of radix rehmanniae, 6 parts of radix scrophulariae, 8 parts of bulbus fritillariae cirrhosae and 5 parts of angelica sinensis. The inventor considers that pulmonary tuberculosis falls under the category of tuberculosis, wherein hemoptysis is one of the cardinal symptoms of tuberculosis; the affection mechanism attributes to the insufficiency of the lung and kidney, fire excess from yin deficiency, damage of collaterals in lung by dryness-heat, failure of blood to circulate in the vessels and blood stasis accumulation; the principle of treatment gives priority to nourishing yin for lowering fire, blood coagulation and blood stasis dissipation. In the formula, radix ophiopogonis, radix rehmanniae and radix scrophulariae have the effects of clearing deficient heat, tonifying kidney yin and benefiting lung yin; bulbus fritillariae cirrhosae has the effect of relieving a cough and reducing sputum; angelica sinensis has the effect of promoting blood circulation to remove blood stasis and ensuring blood to circulate in the vessels. The various crude drugs are combined, so that the purpose of lowering deficiency fire, nourishing lung and kidney and dispelling stasis to stanch bleeding is achieved, the fact that as the medicine takes effect, the symptoms are lessened can be basically achieved. Clinical experiment results prompt that the medicine provided by the invention can be effectively applied to treatment for phthisic hemoptysis.

Description

A kind of medicine being used for the treatment of hemoptysis of pulmonary tuberculosis

Technical field

The present invention relates to a kind of medicine, be specifically related to a kind of Chinese medicine being used for the treatment of hemoptysis of pulmonary tuberculosis.

Background technology

Pulmonary tuberculosis is a kind of chrome lung infectious disease caused by tubercule bacillus invasion and attack pulmonary.Spitting of blood is one of lunger's common clinical manifestation, how is raised gradually by the permeability of pulmonary lesions and surrounding capillaries wall thereof, the focus aneurysm expanded arround invasion and attack in blood vessel, pulmonary cavity occurs breaking or blood vessel occurs that fracture causes.Different according to spitting of blood amount, the clinical manifestation of patient is also different, from gently to heavy, can show as sputum mixed with blood respectively, whole mouth spits blood even massive hemoptysis.

Western medicine method has following several for the medicine stopped blooding: (1) pituitrin, by directly improving smooth muscle irritability, promote that pulmonary's small artery shrinks, reduce pulmonary circulatory blood volume, the blood pressure of pulmonary circulation is impelled to reduce, promote systemic blood pressure, and to accelerate platelet aggregation be that thrombosis is to reach hemostasis object; (2) carbazochrome salicylate, has improvement result to capillary permeability; (3) 6-aminocaprolc acid, tranamic acid, by accelerating blood coagulation rate, to reach hemostasis object.Wherein, pituitrin is the choice drug stopped blooding clinically, but temporarily promotes because it can cause blood pressure, therefore can cause occurring vomiting, stomachache, awareness of defecation sense, headache etc.

Medical material involved in the present invention is all recorded in " China's book on Chinese herbal medicine ".

Summary of the invention

The present invention aims to provide a kind of medicine being used for the treatment of hemoptysis of pulmonary tuberculosis, by selecting suitable medical material and proportioning thereof, reaches the safe and effective object being applied to hemoptysis of pulmonary tuberculosis treatment.

In order to achieve the above object, the present invention is by the following technical solutions:

Be used for the treatment of a medicine for hemoptysis of pulmonary tuberculosis, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: Radix Ophiopogonis 9 parts, 6 parts, the Radix Rehmanniae, Radix Scrophulariae 6 parts, Bulbus Fritillariae Cirrhosae 8 parts, Radix Angelicae Sinensis 5 parts.

Inventor thinks, pulmonary tuberculosis belongs to " pulmonary tuberculosis " category, and wherein spitting of blood is one of main symptom of pulmonary tuberculosis, and pathological changes mechanism is lung kidney deficiency, hyperactivity of fire caused by deficiency of YIN, and lung network is by burning, and escape of blood from meridians, stores and form the stasis of blood, and Therapeutic Principle is nourishing YIN to lower pathogenic fire, and blood coagulation blood stasis dispelling is main.Radix Ophiopogonis, the Radix Rehmanniae, Radix Scrophulariae clearind deficient heat, nourishing kidney-yin, lung benefiting the moon in we; Tendril-leaved fritillary bulb cough-relieving reduces phlegm; Radix Angelicae Sinensis blood circulation promoting and blood stasis dispelling, draw blood return through.All medicines share, and reach the object of moving back asthenic fire, nourishing the lung and kidney, hemostasis by removing blood stasis, substantially can accomplish that As the medicine took effect, the symptoms lessened.

Below in conjunction with clinical laboratory data, beneficial effect of the present invention is described:

1, clinical data

1.1 physical data

Inventor collects lunger 120 example in June ,-2014 in March, 2011, is divided into 2 groups at random.Treatment group 60 example, man 31 example, female 29 example, age 24-68 year, average 49.0 years old, spitting of blood time 1-4 days, average 2.5 days; A large amount of spitting of blood 12 example, middle amount spitting of blood 24 example, in a small amount spitting of blood 24 example.Matched group 60 example, man 30 example, female 30 example, age 26-72 year, average 47.5 years old, spitting of blood time 1-5 days, average 2 days; A large amount of spitting of blood 8 example, middle amount spitting of blood 26 example, in a small amount spitting of blood 26 example.The physical data such as two groups of Genders, age, courses of disease compare, and do not have significant difference, have comparability.

1.2 diagnostic criteria

Meet following arbitrary project and be diagnosed as pulmonary tuberculosis:

(1) checked by Sputum smears and cultivation, all can find tulase and exist;

(2) Sputum smears or Sputum culturing check that tulase result is negative, but the visible typical pulmonary tuberculosis activeness pathological changes of C-XF;

(3) get lung lesions specimen to carry out pathological examination and be diagnosed as pulmonary tuberculosis person;

(4) the visible abnormal shade of rabat, there is spitting of blood in various degree, cough, night sweat, become thin, the symptom such as hectic fever, or carry out anti-infective therapy according to pneumonia and continue 2-4 week, pathological changes has no the suspected pulmonary tuberculosis such as absorption, or check X-ray film gets rid of other pathological changes persons;

(5) get rid of the hydrothorax that beyond pulmonary tuberculosis, pulmonary lesion causes, can tuberculous pleuritis be diagnosed as.

1.3 exclusion standard

(1) pulmonary abscess;

(2) lung tumors;

(3) spitting of blood that causes such as pneumonia and heart mitral lesion.

1.4 spitting of blood amount criterions

(1) slightly spit blood: spitting of blood amount is less than 100ml/d;

(2) moderate spitting of blood: spitting of blood amount 100-300ml/d;

(3) severe spitting of blood: spitting of blood amount is greater than 300ml/d.

2, research method

2.1 Therapeutic Method

Treatment group takes the decoct that the present invention obtains according to specific embodiment 1, and every bu morning, noon and afternoon take for three times.

Oral isoniazid+the ethambutol of matched group is oral, takes to specifications.

All treat one month for two groups.

2.2 statistical method

Adopt SPSS 18.0 statistics software data processing.

3, therapeutic outcome

3.1 criterion of therapeutical effect

Effective: in treatment beginning 1 week, spitting of blood symptom stops, nothings bleeding again in 2 weeks;

Effective: in treatment beginning 1 week, spitting of blood symptom obviously alleviates, nothings bleeding again in 2 weeks;

Invalid: in treatment beginning 1 week, spitting of blood symptom, without obvious alleviation, need select other treatment scheme.

3.2 result

Through the treatment of 1 month, effective 39 examples in treatment group patient, effective 19 examples, invalid 2 examples, total effective rate is 96.7%; Effective 25 examples in matched group patient, effective 22 examples, invalid 13 examples, total effective rate is 78.3%.Two groups of comparitive study, the total effective rate for the treatment of group is significantly higher than matched group, P < 0.05.

Visible, the medicine that the present invention obtains can safe and effective treatment hemoptysis of pulmonary tuberculosis, has good medical science promotional value.

Detailed description of the invention

In order to understand better and implement the present invention, further illustrate the present invention below in conjunction with specific embodiment.

Embodiment 1

Take: Radix Ophiopogonis 9 grams, 6 grams, the Radix Rehmanniae, Radix Scrophulariae 6 grams, Bulbus Fritillariae Cirrhosae 8 grams, Radix Angelicae Sinensis 5 grams; Add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, is concentrated into 120 grams, must meet the decoct of adult normal's one day consumption.

Be used for the treatment of hemoptysis of pulmonary tuberculosis.Oral, every bu morning, noon and afternoon take for three times.

Embodiment 2

Take: Radix Ophiopogonis 9 grams, 6 grams, the Radix Rehmanniae, Radix Scrophulariae 6 grams, Bulbus Fritillariae Cirrhosae 8 grams, Radix Angelicae Sinensis 5 grams; Add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1.5 hours, filters; Merging filtrate, concentrated, dry, packaging, must meet the powder of adult normal's one day consumption.

Be used for the treatment of hemoptysis of pulmonary tuberculosis.Oral, daily once.

Embodiment 3

Take: Radix Ophiopogonis 9 grams, 6 grams, the Radix Rehmanniae, Radix Scrophulariae 6 grams, Bulbus Fritillariae Cirrhosae 8 grams, Radix Angelicae Sinensis 5 grams; Add 6 times of water gagings, decoct 3 times, each decoction 1 hour, merges decoction liquor, concentrated, dry, incapsulates shell, must meet the capsule of adult normal's one day consumption.

Be used for the treatment of hemoptysis of pulmonary tuberculosis.Oral, every bu is taken for twice sooner or later.

Claims

1. be used for the treatment of a medicine for hemoptysis of pulmonary tuberculosis, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: Radix Ophiopogonis 9 parts, 6 parts, the Radix Rehmanniae, Radix Scrophulariae 6 parts, Bulbus Fritillariae Cirrhosae 8 parts, Radix Angelicae Sinensis 5 parts.