CN102579778B - Traditional Chinese medicine for treating Behcet disease and Behcet syndrome - Google Patents
Traditional Chinese medicine for treating Behcet disease and Behcet syndrome Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine for treating Behcet disease and Behcet syndrome. The traditional Chinese medicine serves as an effective drug to treat the Behcet disease and the Behcet syndrome. The technical scheme is that the traditional Chinese medicine comprises the following components by weight: 13g-17g of cordyceps sinensis, 13g-17g of coptidis rhizoma, 13g-17g of baical skullcap roots, 13g-17g of amoorcorn tree bark, 18g-22g of flos lonicerae, 18g-22g of fructus forsythiae, 11g-13g of radices paeoniae rubra, 11g-13g of moutan cortex, 11g-13g of radices lithospermi, 9g-11g of rhizoma anemarrhenae and 9g-11g of gypsum, wherein the cordyceps sinensis, the coptidis rhizoma, the baical skullcap roots, the amoorcorn tree bark, the flos lonicerae and the fructus forsythiae are smashed to powder, pass through a 300-mesh sieve and are mixed uniformly into fine powder for later use; the gypsum, the rhizoma anemarrhenae, the radices lithospermi, the moutan cortex and the radices paeoniae rubra are mixed together and then are immersed and decocted twice for 1.5 hours per time, solutions in the twice decoction are combined and then are concentrated into extract;and the fine powder and the extract are mixed to a medicament lump which is made to pills, and the pills are coated and packaged after being dried at 80 DEG C to be less than 5% in moisture. The traditional Chinese medicine can be used for treating the Behcet disease and the Behcet syndrome effectively, has a good curative effect, has no toxic and side effects, and is safe and reliable.
Description
Technical field
The present invention relates to field of medicaments, particularly a kind of Chinese medicine for the treatment of behcets disease and behcet's syndrome.
Background technology
Behcets disease and behcet's syndrome are a kind of chronic vasculitis inflammatory disease property disease (general designation Behcet disease), and be different with other vasculitis diseases, and it can involve the large, medium and small blood vessel of whole body, wherein gets involved at most with vein.Main clinical manifestation is recurrent oral ulceration, genitality ulcer, ophthalmia and skin lesion etc., also can involve organs such as blood vessel, nervous system, digestive tract, joint, lung, kidney, epididymis, is a systemic disease.If many prognosis are not good after involving eye, nervus centralis and trunk.Epstein-Barr virus, herpes simplex virus, streptococcus, tubercle bacillus affection, and immune genetic factor (HLA-B51) may fall ill relevant with primary disease.Generally this disease is divided into two kinds of perfect form and forme frustes at present according to medical history and symptom.Possess mouthful, eye, genitals three persons of levying be perfect form.Observe according to us, even the perfect form patient, its mouthful, eye, genitals three are levied also and are not necessarily occurred simultaneously.
Chinese medicine is recognized the substantial connection of system factor and diseases of oral mucosa very early, for example: " conscience has the normal aphtha of suffering from of heat " " medical secrets of official ": " aphtha person, conscience has heat, and gas rushes to Jiao, a smoked dispute is pretended skin ulcer also "; Again " stomach-QI being weak, essence derived from food is few, empty sun is gone up and is sent out and be aphtha " " Shengji Zonglu ".Ming Dynasty Xue mentions " part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels YIN-fire is individual due to the change of disease, when controlling it respectively for aphtha part of the body cavity above the diaphragm housing the heart and lungs excess-heat, deficiency-cold in middle-JIAO " in " ability to speak class want ".Illustrate that upper, middle and lower three warmers deficiency and excess cold and heat can both cause aphtha, and each internal organs meridians pathological changes change of disease mutually.At present still very not clear and definite to the cause of disease of Behcet disease.Someone thinks viral infection or infective agent is produced anaphylaxis to cause, but is also proved fully.
Behcet disease removes common oral ulcer, genital ulcer, and outside the infringement of eyes, skin lesion is the higher a kind of performance of a species specificity.The pathological changes of the performance of patient's digestive system and general digestive tract disease is easy to obscure, in the treatment as actively not controlling protopathy by digestive tract disease treatment, can not obtain satisfied curative effect.The Behcet disease course of disease is long, reached at the many decades that has, and various symptoms may be shown effect repeatedly, but and spontaneous remission.The skin lesion sickness rate of Behcet disease is very high, can reach 98%, shows varied.Oral cavity and skin lesion be the back no sequel more.The sick severe patient that decreases of eye has blind danger.Small number of patients is because seriously internal organs or nervous lesion cause death.Though it is the medicine of multiple treatment behcets disease and behcet's syndrome is arranged at present, and for various reasons, its therapeutic effect is all not fully up to expectations, therefore, imperative to the innovation for the treatment of behcets disease and behcet's syndrome medicine.
Summary of the invention
At above-mentioned situation, for solving the defective of prior art, purpose of the present invention just provides a kind of Chinese medicine for the treatment of behcets disease and behcet's syndrome, can effectively solve the medicine for treatment problem of dialogue Sai Shi disease and behcet's syndrome.
Technical scheme of the present invention is, this Chinese medicine is by the weight meter: Cordyceps 13-17g, Rhizoma Coptidis 13-17g, Radix Scutellariae 13-17g, Cortex Phellodendri 13-17g, Flos Lonicerae 18-22g, Fructus Forsythiae 18-22g, Radix Paeoniae Rubra 11-13g, Cortex Moutan 11-13g, Radix Arnebiae (Radix Lithospermi) 11-13g, Rhizoma Anemarrhenae 9-11g, Gypsum Fibrosum 9-11g makes, wherein Cordyceps, Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Fructus Forsythiae, Flos Lonicerae are ground into powder respectively, cross 300 mesh sieves, be mixed into thin medicated powder, standby; With Gypsum Fibrosum, the Rhizoma Anemarrhenae, Radix Arnebiae (Radix Lithospermi), Radix Paeoniae Rubra, Cortex Moutan totally 5 flavors mix, add water to submerge and decoct 2 times, decocted 1.5 hours at every turn, merge twice decocting liquid, relative density is the extractum of 1.20-1.30 when being concentrated into 50 ℃; Above-mentioned thin medicated powder is mixed with extractum and patent medicine sticks together, make pill, 80 ℃ are dried to moisture less than after 5%, take out, and carry out coating, packing and packing according to a conventional method.
The present invention can adopt conventional method to make decoction, powder (powder), tablet, pill or capsule as required and take, and is effective to treat behcets disease and behcet's syndrome, good effect, and the avirulence side effect, safe and reliable.
The specific embodiment
Elaborate below in conjunction with the specific embodiment of the present invention of embodiment.
The present invention can be provided by following examples in concrete enforcement.
Embodiment 1
The present invention in concrete enforcement by following weight meter: Cordyceps 15g, Rhizoma Coptidis 15g, Radix Scutellariae 15g, Cortex Phellodendri 15g, Flos Lonicerae 20g, Fructus Forsythiae 20g, Radix Paeoniae Rubra 12g, Cortex Moutan 12g, Radix Arnebiae (Radix Lithospermi) 12g, Rhizoma Anemarrhenae 10g, Gypsum Fibrosum 10g makes, and wherein Cordyceps, Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Fructus Forsythiae, Flos Lonicerae is ground into powder respectively, crosses 300 mesh sieves, be mixed into thin medicated powder, standby; Gypsum Fibrosum, the Rhizoma Anemarrhenae, Radix Arnebiae (Radix Lithospermi), Radix Paeoniae Rubra, Cortex Moutan are mixed, add water to submerge decoction 2 times, decocted 1.5 hours at every turn, merge twice decocting liquid, relative density is the extractum of 1.20-1.30 when being concentrated into 50 ℃; Above-mentioned thin medicated powder is mixed with extractum and patent medicine sticks together, make pill, 80 ℃ are dried to moisture less than after 5%, take out, and the pill of drying is put rotated pot in the coating pan, add an amount of syrup, stir, when treating that the pill surface is burr shape and the ball heart and runs through, add an amount of Pulvis Talci, stir, Pulvis Talci is all wrapped up in invested the pill surface, add syrup again, add Pulvis Talci, so repeatedly, with hair-dryer pill is dried up, stop blowing then, add syrup again, stir, pill surface uniformity is as the criterion, and when treating that the pill surface is slightly done, the reheat blowing dries up ball, add the wax powder then, pivoting friction, takes the dish out of the pot very till the light to the ball surface, places room temperature, put in the clean container, pill is pressed the packing of 90g/ bottle, and labeling after accurately clearly adding a cover lot number on the label is packed.
Embodiment 2
The present invention in concrete enforcement by following weight meter: Cordyceps 13g, Rhizoma Coptidis 13g, Radix Scutellariae 13g, Cortex Phellodendri 13g, Flos Lonicerae 18g, Fructus Forsythiae 18g, Radix Paeoniae Rubra 11g, Cortex Moutan 11g, Radix Arnebiae (Radix Lithospermi) 11g, Rhizoma Anemarrhenae 9g, Gypsum Fibrosum 9g makes, and wherein Cordyceps, Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Fructus Forsythiae, Flos Lonicerae is ground into powder respectively, crosses 300 mesh sieves, be mixed into thin medicated powder, standby; Gypsum Fibrosum, the Rhizoma Anemarrhenae, Radix Arnebiae (Radix Lithospermi), Radix Paeoniae Rubra, Cortex Moutan are mixed, add water to submerge decoction 2 times, decocted 1.5 hours at every turn, merge twice decocting liquid, relative density is the extractum of 1.20-1.30 when being concentrated into 50 ℃; Above-mentioned thin medicated powder is mixed with extractum and patent medicine sticks together, make pill, 80 ℃ are dried to moisture less than after 5%, take out, and the pill of drying is put rotated pot in the coating pan, add an amount of syrup, stir, when treating that the pill surface is burr shape and the ball heart and runs through, add an amount of Pulvis Talci, stir, Pulvis Talci is all wrapped up in invested the pill surface, add syrup again, add Pulvis Talci, so repeatedly, with hair-dryer pill is dried up, stop blowing then, add syrup again, stir, pill surface uniformity is as the criterion, and when treating that the pill surface is slightly done, the reheat blowing dries up ball, add the wax powder then, pivoting friction, takes the dish out of the pot very till the light to the ball surface, places room temperature, put in the clean container, pill is pressed the packing of 90g/ bottle, and labeling after accurately clearly adding a cover lot number on the label is packed.
Embodiment 3
The present invention in concrete enforcement by following weight meter: Cordyceps 16g, Rhizoma Coptidis 16g, Radix Scutellariae 16g, Cortex Phellodendri 16g, Flos Lonicerae 19g, Fructus Forsythiae 19g, Radix Paeoniae Rubra 12g, Cortex Moutan 12g, Radix Arnebiae (Radix Lithospermi) 12g, Rhizoma Anemarrhenae 10g, Gypsum Fibrosum 10g makes, and wherein Cordyceps, Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Fructus Forsythiae, Flos Lonicerae is ground into powder respectively, crosses 300 mesh sieves, be mixed into thin medicated powder, standby; Gypsum Fibrosum, the Rhizoma Anemarrhenae, Radix Arnebiae (Radix Lithospermi), Radix Paeoniae Rubra, Cortex Moutan are mixed, add water to submerge decoction 2 times, decocted 1.5 hours at every turn, merge twice decocting liquid, relative density is the extractum of 1.20-1.30 when being concentrated into 50 ℃; Above-mentioned thin medicated powder is mixed with extractum and patent medicine sticks together, make pill, 80 ℃ are dried to moisture less than after 5%, take out, and the pill of drying is put rotated pot in the coating pan, add an amount of syrup, stir, when treating that the pill surface is burr shape and the ball heart and runs through, add an amount of Pulvis Talci, stir, Pulvis Talci is all wrapped up in invested the pill surface, add syrup again, add Pulvis Talci, so repeatedly, with hair-dryer pill is dried up, stop blowing then, add syrup again, stir, pill surface uniformity is as the criterion, and when treating that the pill surface is slightly done, the reheat blowing dries up ball, add the wax powder then, pivoting friction, takes the dish out of the pot very till the light to the ball surface, places room temperature, put in the clean container, pill is pressed the packing of 90g/ bottle, and labeling after accurately clearly adding a cover lot number on the label is packed.
Embodiment 4
The present invention in concrete enforcement by following weight meter: Cordyceps 17g, Rhizoma Coptidis 17g, Radix Scutellariae 17g, Cortex Phellodendri 17g, Flos Lonicerae 22g, Fructus Forsythiae 22g, Radix Paeoniae Rubra 13g, Cortex Moutan 13g, Radix Arnebiae (Radix Lithospermi) 13g, Rhizoma Anemarrhenae 11g, Gypsum Fibrosum 11g makes, and wherein Cordyceps, Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Fructus Forsythiae, Flos Lonicerae is ground into powder respectively, crosses 300 mesh sieves, be mixed into thin medicated powder, standby; Gypsum Fibrosum, the Rhizoma Anemarrhenae, Radix Arnebiae (Radix Lithospermi), Radix Paeoniae Rubra, Cortex Moutan are mixed, add water to submerge decoction 2 times, decocted 1.5 hours at every turn, merge twice decocting liquid, relative density is the extractum of 1.20-1.30 when being concentrated into 50 ℃; Above-mentioned thin medicated powder is mixed with extractum, stick together with patent medicine, make pill, 80 ℃ are dried to moisture less than after 5%, take out, the pill of drying is put rotation pot in the coating pan, add an amount of syrup, stir, when treating that the pill surface is burr shape and the ball heart and runs through, add an amount of Pulvis Talci, stir, Pulvis Talci is all wrapped up in invested the pill surface, add syrup again, add Pulvis Talci, so repeatedly, with hair-dryer pill is dried up, stop blowing then, add syrup again, stir, pill surface uniformity is as the criterion.When treating that pill surface is slightly done, the reheat blowing dries up ball, adds the wax powder then, and pivoting friction is to the ball surface very till the light, take the dish out of the pot, place room temperature, put in the clean container, pill is pressed the packing of 90g/ bottle, and labeling after accurately clearly adding a cover lot number on the label is packed.
Embodiment 5
The present invention in concrete enforcement by following weight meter: Cordyceps 14g, Rhizoma Coptidis 14g, Radix Scutellariae 14g, Cortex Phellodendri 14g, Flos Lonicerae 21g, Fructus Forsythiae 21g, Radix Paeoniae Rubra 12g, Cortex Moutan 12g, Radix Arnebiae (Radix Lithospermi) 12g, Rhizoma Anemarrhenae 11g, Gypsum Fibrosum 11g makes, and wherein Cordyceps, Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Fructus Forsythiae, Flos Lonicerae is ground into powder respectively, crosses 300 mesh sieves, be mixed into thin medicated powder, standby; Gypsum Fibrosum, the Rhizoma Anemarrhenae, Radix Arnebiae (Radix Lithospermi), Radix Paeoniae Rubra, Cortex Moutan are mixed, add water to submerge decoction 2 times, decocted 1.5 hours at every turn, merge twice decocting liquid, relative density is the extractum of 1.20-1.30 when being concentrated into 50 ℃; Above-mentioned thin medicated powder is mixed with extractum, stick together with patent medicine, make pill, 80 ℃ are dried to moisture less than after 5%, take out, the pill of drying is put rotation pot in the coating pan, add an amount of syrup, stir, when treating that the pill surface is burr shape and the ball heart and runs through, add an amount of Pulvis Talci, stir, Pulvis Talci is all wrapped up in invested the pill surface, add syrup again, add Pulvis Talci, so repeatedly, with hair-dryer pill is dried up, stop blowing then, add syrup again, stir, pill surface uniformity is as the criterion.When treating that pill surface is slightly done, the reheat blowing dries up ball, adds the wax powder then, and pivoting friction is to the ball surface very till the light, take the dish out of the pot, place room temperature, put in the clean container, pill is pressed the packing of 90g/ bottle, and labeling after accurately clearly adding a cover lot number on the label is packed.
The present invention also can suitably adjust prescription according to patient's state of an illness difference when concrete compatibility, and this Chinese medicine is a kind of of conventional method decoction, powder, tablet, pill or the capsule made.
In the medicine of the present invention:
Cordyceps: remove outer hymeniderm, dry to give birth to and use.Function cures mainly: the kidney invigorating lung benefiting, the merit that hemostasis and phlegm, relieving cough and asthma, the kidney invigorating solid, tonifying the lung benefit are defended, is the key medicine of the deficient and immune disease of all consumptive diseases at flat tonifying the lung kidney yin sun.
Rhizoma Coptidis: remove impurity, run through the back shave and dry, give birth to use.Function cures mainly: heat clearing and damp drying, eliminating fire and detoxication.Hyperactivity of heart-fire, dysphoria and insomnia, the carbuncle furuncle is quenched one's thirst in toothache; The kind clear part of the body cavity above the diaphragm housing the heart and lungs of Rhizoma Coptidis is burning hot, is used for conjunctival congestion, aphtha, antiulcer.
Radix Scutellariae: impurity is removed in cutting, puts to steam in the container and steams half an hour, takes out airing shave, drying.Function cures mainly: heat clearing and damp drying, eliminating fire and detoxication.Antimicrobial antiphlogistic and raising immunologic function.
Cortex Phellodendri: salt is produced the Cortex Phellodendri silk, mixes thoroughly with saline, and is stewing saturating, puts pot interior slow fire and fry dried.Take out, cool.Function cures mainly: heat-clearing and toxic substances removing, eliminating fire and detoxication, antibiotic antiulcer.
Flos Lonicerae: bright product dry in the shade to give birth to and use.Function cures mainly: heat-clearing and toxic substances removing, dispelling wind and heat pathogens.The crude drug sweet and slightly bitter taste, cold in nature, the poison of the kind removing summer-heat part of the body cavity above the diaphragm housing the heart and lungs and flesh table is evil.Be mainly used in epidemic febrile disease and carbuncle furunculosis, Flos Lonicerae has the title of " panacea of infections section " from ancient times.Normal and Herba Taraxaci, Herba Violae, Flos Chrysanthemi Indici etc. share, and can strengthen the removing toxic substances and promoting subsidence of swelling effect.For carbuncle furuncle poison, congestion and swelling pain, the still routed pus person of pus that no matter bursts uses Flos Lonicerae (consumption should weigh) all can play excellent effect.It is the good merchantable brand of anti-inflammation, antiviral and raise immunity.
Fructus Forsythiae: remove impurity, destemming, cook, dry.Function cures mainly: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, dispelling wind and heat pathogens.Detoxifcation, antiinflammatory, resisting pathogenic microbes." persons particularly liable to develop skin infection's panacea " arranged.
Radix Paeoniae Rubra: choose decontamination, separately size bar washes bubble about seven, eighty per cant with water thoroughly, pulls out, and solarization is dried in the air, and profit is even to inside and outside humidity, and section is dried.Function cures mainly: blood stasis dispelling, relieve the pain, removing heat from blood, detumescence.Pharmacological research has good antiinflammatory, antithrombotic, anti-platelet aggregation and hepatoprotective effect.
Cortex Moutan: choose decontamination, remove core, clean, run through, section is dried.Function cures mainly: clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling.Modern pharmacological research this product has antiinflammatory sterilization, antiulcer, atherosclerosis and anti-platelet aggregation effect.
Radix Arnebiae (Radix Lithospermi): remove impurity, clean, run through shave, drying.Function cures mainly: clearing away heat and cooling blood, to invigorate blood circulation, and detoxifcation is examined thoroughly.Be used for the heat in blood poison and win, macule is purple black, measles without adequate eruption, and, be used for that the heat in blood poison is contained, purple black, the measles without adequate eruption of macule, skin infection, eczema, burn due to hot liquid or fire.Clearing away heat and cooling blood is used for measles, the calentura skin eruption, and eczema, hematuria, stranguria with blood, dysentery, skin infection, erysipelas, burn, constipation with heat retention, skin infection are burst for a long time and are not held back.
The Rhizoma Anemarrhenae:. salt is produced Rhizoma Anemarrhenae sheet, mixes thoroughly or sprays evenly with saline, and stewing saturating, it is husky dried to put interior the slow fire of pot, and taking-up cools.Every Rhizoma Anemarrhenae sheet 100kg uses Sal 2kg.Function cures mainly: nourishing YIN to lower pathogenic fire, moisturize laxation.Control dysphoria with smothery sensation and quench one's thirst, hectic fever due to YIN-deficiency consumptive fever, cough due to lung-heat, constipation due to dry stool, dysuria, epidemic febrile disease.That modern pharmacological research this product has is analgesic, antitumor and anti-multiple source of disease microorganism.
Gypsum Fibrosum: cleaning, drying, smash, remove roguing stone, grind coarse powder.Function cures mainly: expelling pathogenic factors from muscles for clearing heat, relieving restlessness is quenched the thirst.The calentura high fever does not move back; Vexed coma; Delirium is gone mad; Thirsty and dry pharynx; The lung-heat dyspnea with rapid respiration; The heatstroke spontaneous perspiration; The stomach-fire headache; Toothache due to stomach-fire; Hyperactivity of toxic heat; Send out the speckle dermexanthesis; Aphtha of the mouth and tongue; Ulcer sores; Burst and do not close up; The burning hot wound of soup.
By last all medicine compatibilities as can be known, the present invention's summary of experience has interior-heat, Eradicates noxious dampness expelling pus and promoting granulation raise immunity clearly.Be applicable to the treatment of all types of Behcets and behcet's syndrome, taking convenience, simple, effective, clinical data fully proves.Concrete relevant clinical data of the present invention is as follows:
The clinical manifestation of behcets disease has following several: 1, oral ulcer repeatedly; 2, dermatosis: erythema nodosa, subcutaneous angiitis obliterans, folliculitis sample erythra, acneform eruptions; 3, oculopathy becomes: iridocyclitis, retinitis; 4, vulval ulcer; 5, there is not lopsided arthritis; 6, epididymitis; 7, ileocecus ulcer is main digestive system pathological changes; 8, vascular lesion; 9, the above central neuropathy of moderate.The behcets disease characteristic symptom has: 1, arthralgia, and minority has redness, invades high pointes such as knee joint, wrist, elbow, ankle more, does not have obvious migration, but easily recurrence is modal symptom in the characteristic symptom; 2, the cardiovascular infringement can betide heart, causes cardiac dilatation, myocarditis and pericarditis etc.Pathological changes all can take place in the artery and vein blood vessel, causes blood vessel infraction or aneurysm etc., causes corresponding symptom such as parts of body such as lung, kidney etc., as spitting of blood, renal hypertension etc.3, non-specific digestive tract ulcer and digestive tract hemorrhage have symptoms such as stomachache, diarrhoea, abdominal distention.4, because the pathological changes of blood vessel can cause cough, spitting of blood, chest pain, interstitial pulmonary fibrosis.The conducting lung X-ray examination inspection shade etc. occurs and is the performance of lung infraction; 5, the more perineural infringement of central nervous system's symptom is seen more, mainly show as meningoencephalitis syndrome, brain stem syndrome or organic mental disorder syndrome, its symptom has headache, dizziness, hypomnesis in early days, generations such as aphasis, ataxia, neck rigidity, hemiplegia are arranged later on, cause respiratory paralysis and death when serious; 6, the part patient has the medical history of generating heat repeatedly, is hyperpyrexia or low grade fever.This type of patient is rheumatism or tuberculosis etc. by mistaken diagnosis easily when with erythema nodosum or joint, lung symptoms.4 fundamental symptomss occur or 2 fundamental symptomss occur and 2 above characteristic symptoms, be perfect form; 3 fundamental symptomss or the symptom that goes out to lose face and another fundamental symptoms occur, be forme fruste.
The diagnostic criteria of behcets disease, behcet's syndrome:
1. the diagnosis of trunk or nervous system damage height prompting BD appears in the recurrent oral ulceration that has the doctor to observe in the clinical manifestation course of disease and be recorded to, ophthalmia, genital ulcer and characteristic skin lesion in addition.2. the lab testing primary disease does not have the specificity laboratory abnormalities.Active stage can have that erythrocyte sedimentation rate speeds, C one reactive protein raises; Part patient's cryoglobulin positive.The platelet aggregation increased functionality.HLA-B 51 positive rate 57%--88% in a disguised form close with eye, digestive tract disease.3. the neural Behcet disease of special examined often has cerebrospinal pressure to increase, and leukocyte count slightly raises.Brain CT and magnetic resonance (MRI) inspections have certain help to brain, brain stem and myeleterosis, and the inspection sensitivity of acute stage MRI can be found the signal that increases at brain stem, ventricles of the brain aside matter and Basal ganglia place up to 96.5%.Chronic phase row MRI checks and should note differentiating mutually with multiple sclerosis.MRI can be used for neural Behcet disease diagnosis and therapeutic effect follow-up observation.Gastrointestinal barium agent radiography and splanchnoscopy, angiography, colored Doppler help diagnosis diseased region and scope.Pneumonograph can show as list or bilateral diffusivity not of uniform size is oozed out or circular nodular shadow, can show as the fuzzy shadow of hilus pulumonis increase in density on every side during pulmonary infarction.High-resolution CT or angiopneumography, isotope pulmonary ventilation (perfusion) scanning etc. all help the pulmonary lesion diagnosis.4. acupuncture reaction test (Pathergy test) is bent the about 0.5cm of face middle part perpendicular insertion people with No. 20 aseptic syringe needles at forearm and is longitudinally done slightly and withdraw from after twisted, and diameter appears in the part behind the 24-48h〉folliculitis sample small red dot or the pustular eruption sample of 2mm change into the positive.This test specificity is higher and relevant with disease activity.The similar skin lesion that occurs behind venipuncture or the skin trauma has equal value.
Prescription of the present invention has all been obtained extraordinary effect through repeatedly clinical trial, and relevant experimental data is as follows:
Therapeutic scheme:
The oral Chinese medicine of the present invention of patient, every day three times, each 9g, the child is cut down according to the circumstance, and takes half an hour after meal, and the forme fruste behcet's syndrome common 2 months was a course for the treatment of, and the behcet's syndrome of perfect form is added up therapeutic outcome 3 courses for the treatment of.
Efficacy assessment standard:
Clinical cure: 1, oral ulcer, genital ulcer, eyes ulcer, arthralgia, erythema nodosum complete obiteration; 2, immunologic function is recovered the normal recurrence that is difficult for; 3, not its any treatment of Xingqi.
Produce effects: symptoms such as does not ache in oral cavity, genitals, the healing of eyes ulcer surface, joint, erythema disappearance obviously alleviate.
Effectively: symptoms such as oral ulcer, genital ulcer, eyes ulcer, joint, erythema nodosum are all than alleviating before the treatment.
Invalid: as not have any sign and improve performance.
Statistical disposition:
Through 150 routine behcets diseases, behcet's syndrome patient are observed, clinical cure is transference cures such as oral ulcer, genital ulcer, eyes ulcer.It is normal that immunity is recovered, and follows up a case by regular visits to no recidivist's 73 examples after the drug withdrawal; Produce effects is all obvious alleviator's 41 examples of symptoms such as oral ulcer, genital ulcer, eyes ulcer, joint, erythema nodosum; Effectively be symptoms such as oral ulcer, genital ulcer, eyes ulcer, joint, erythema nodosum all than the treatment before alleviator's 23 examples, total effective rate reaches 94%, and long-term effect is preferably arranged.Primary disease is that immunologic hypofunction causes mostly, and prolonged and repeated outbreak has a delicate constitution, the general immune dysfunction, and treatment needs long-term, and the course for the treatment of is long, and effect is better.But some patient is uncomplaisance often, eating and drinking without temperance or be difficult to adhere to and affect the treatment.In addition, it is heavier repeatedly to send out the author repeatedly in all 1 year, and brain Behcet and neural Behcet curative effect are relatively poor.These need further improvement.
Shown that by above-mentioned data the present invention can improve behcets disease, behcet's syndrome patient's clinical symptoms, palliates the agonizing sufferings, life-saving, harmless to the heart, liver, kidney, drug safety, stable curative effect is the active drug for the treatment of behcets disease, behcet's syndrome, easily manufactures, easy to carry, effective, expense is low, actual clinical meaning is arranged, for the behcets disease patient provides the good curing condition, be that of Chinese medicine and pharmacy creates greatly, make and benefit society.
Claims (6)
1. a Chinese medicine for the treatment of behcets disease and behcet's syndrome is characterized in that, this Chinese medicine is by the weight meter: Cordyceps 13-17g, Rhizoma Coptidis 13-17g, Radix Scutellariae 13-17g, Cortex Phellodendri 13-17g, Flos Lonicerae 18-22g, Fructus Forsythiae 18-22g, Radix Paeoniae Rubra 11-13g, Cortex Moutan 11-13g, Radix Arnebiae (Radix Lithospermi) 11-13g, Rhizoma Anemarrhenae 9-11g, Gypsum Fibrosum 9-11g makes, and wherein Cordyceps, Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Fructus Forsythiae, Flos Lonicerae is ground into powder respectively, crosses 300 mesh sieves, be mixed into thin medicated powder, standby; Gypsum Fibrosum, the Rhizoma Anemarrhenae, Radix Arnebiae (Radix Lithospermi), Radix Paeoniae Rubra, Cortex Moutan are mixed, add water to submerge decoction 2 times, decocted 1.5 hours at every turn, merge twice decocting liquid, relative density is the extractum of 1.20-1.30 when being concentrated into 50 ℃; Above-mentioned thin medicated powder is mixed with extractum and patent medicine sticks together, make pill, 80 ℃ are dried to moisture less than after 5%, coating, packing.
2. the Chinese medicine for the treatment of behcets disease according to claim 1 and behcet's syndrome is characterized in that, this Chinese medicine is by the weight meter: Cordyceps 15g, Rhizoma Coptidis 15g, Radix Scutellariae 15g, Cortex Phellodendri 15g, Flos Lonicerae 20g, Fructus Forsythiae 20g, Radix Paeoniae Rubra 12g, Cortex Moutan 12g, Radix Arnebiae (Radix Lithospermi) 12g, Rhizoma Anemarrhenae 10g, Gypsum Fibrosum 10g makes, and wherein Cordyceps, Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Fructus Forsythiae, Flos Lonicerae is ground into powder respectively, crosses 300 mesh sieves, be mixed into thin medicated powder, standby; Gypsum Fibrosum, the Rhizoma Anemarrhenae, Radix Arnebiae (Radix Lithospermi), Radix Paeoniae Rubra, Cortex Moutan are mixed, add water to submerge decoction 2 times, decocted 1.5 hours at every turn, merge twice decocting liquid, relative density is the extractum of 1.20-1.30 when being concentrated into 50 ℃; Above-mentioned thin medicated powder is mixed with extractum and patent medicine sticks together, make pill, 80 ℃ are dried to moisture less than after 5%, coating, packing.
3. the Chinese medicine for the treatment of behcets disease according to claim 1 and behcet's syndrome is characterized in that, this Chinese medicine is by the weight meter: Cordyceps 13g, Rhizoma Coptidis 13g, Radix Scutellariae 13g, Cortex Phellodendri 13g, Flos Lonicerae 18g, Fructus Forsythiae 18g, Radix Paeoniae Rubra 11g, Cortex Moutan 11g, Radix Arnebiae (Radix Lithospermi) 11g, Rhizoma Anemarrhenae 9g, Gypsum Fibrosum 9g makes, and wherein Cordyceps, Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Fructus Forsythiae, Flos Lonicerae is ground into powder respectively, crosses 300 mesh sieves, be mixed into thin medicated powder, standby; Gypsum Fibrosum, the Rhizoma Anemarrhenae, Radix Arnebiae (Radix Lithospermi), Radix Paeoniae Rubra, Cortex Moutan are mixed, add water to submerge decoction 2 times, decocted 1.5 hours at every turn, merge twice decocting liquid, relative density is the extractum of 1.20-1.30 when being concentrated into 50 ℃; Above-mentioned thin medicated powder is mixed with extractum and patent medicine sticks together, make pill, 80 ℃ are dried to moisture less than after 5%, coating, packing.
4. the Chinese medicine for the treatment of behcets disease according to claim 1 and behcet's syndrome is characterized in that, this Chinese medicine is by the weight meter: Cordyceps 16g, Rhizoma Coptidis 16g, Radix Scutellariae 16g, Cortex Phellodendri 16g, Flos Lonicerae 19g, Fructus Forsythiae 19g, Radix Paeoniae Rubra 12g, Cortex Moutan 12g, Radix Arnebiae (Radix Lithospermi) 12g, Rhizoma Anemarrhenae 10g, Gypsum Fibrosum 10g makes, and wherein Cordyceps, Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Fructus Forsythiae, Flos Lonicerae is ground into powder respectively, crosses 300 mesh sieves, be mixed into thin medicated powder, standby; Gypsum Fibrosum, the Rhizoma Anemarrhenae, Radix Arnebiae (Radix Lithospermi), Radix Paeoniae Rubra, Cortex Moutan are mixed, add water to submerge decoction 2 times, decocted 1.5 hours at every turn, merge twice decocting liquid, relative density is the extractum of 1.20-1.30 when being concentrated into 50 ℃; Above-mentioned thin medicated powder is mixed with extractum and patent medicine sticks together, make pill, 80 ℃ are dried to moisture less than after 5%, coating, packing.
5. the Chinese medicine for the treatment of behcets disease according to claim 1 and behcet's syndrome is characterized in that, this Chinese medicine is by the weight meter: Cordyceps 17g, Rhizoma Coptidis 17g, Radix Scutellariae 17g, Cortex Phellodendri 17g, Flos Lonicerae 22g, Fructus Forsythiae 22g, Radix Paeoniae Rubra 13g, Cortex Moutan 13g, Radix Arnebiae (Radix Lithospermi) 13g, Rhizoma Anemarrhenae 11g, Gypsum Fibrosum 11g makes, and wherein Cordyceps, Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Fructus Forsythiae, Flos Lonicerae is ground into powder respectively, crosses 300 mesh sieves, be mixed into thin medicated powder, standby; Gypsum Fibrosum, the Rhizoma Anemarrhenae, Radix Arnebiae (Radix Lithospermi), Radix Paeoniae Rubra, Cortex Moutan are mixed, add water to submerge decoction 2 times, decocted 1.5 hours at every turn, merge twice decocting liquid, relative density is the extractum of 1.20-1.30 when being concentrated into 50 ℃; Above-mentioned thin medicated powder is mixed with extractum and patent medicine sticks together, make pill, 80 ℃ are dried to moisture less than after 5%, coating, packing.
6. the Chinese medicine for the treatment of behcets disease according to claim 1 and behcet's syndrome is characterized in that, this Chinese medicine is by the weight meter: Cordyceps 14g, Rhizoma Coptidis 14g, Radix Scutellariae 14g, Cortex Phellodendri 14g, Flos Lonicerae 21g, Fructus Forsythiae 21g, Radix Paeoniae Rubra 12g, Cortex Moutan 12g, Radix Arnebiae (Radix Lithospermi) 12g, Rhizoma Anemarrhenae 11g, Gypsum Fibrosum 11g makes, and wherein Cordyceps, Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Fructus Forsythiae, Flos Lonicerae is ground into powder respectively, crosses 300 mesh sieves, be mixed into thin medicated powder, standby; Gypsum Fibrosum, the Rhizoma Anemarrhenae, Radix Arnebiae (Radix Lithospermi), Radix Paeoniae Rubra, Cortex Moutan are mixed, add water to submerge decoction 2 times, decocted 1.5 hours at every turn, merge twice decocting liquid, relative density is the extractum of 1.20-1.30 when being concentrated into 50 ℃; Above-mentioned thin medicated powder is mixed with extractum and patent medicine sticks together, make pill, 80 ℃ are dried to moisture less than after 5%, coating, packing.
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| CN104069230B (en) * | 2014-07-10 | 2016-06-15 | 山东青岛中西医结合医院 | A kind of treat behcets disease gram poison wet soup |
| CN104606596B (en) * | 2015-02-03 | 2018-03-16 | 南阳理工学院 | A kind of Chinese patent drug for treating behcet disease and preparation method thereof |
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| CN101991797A (en) * | 2009-08-25 | 2011-03-30 | 张志通 | Medicine formula for treating Behcet's disease |
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