CN105943623A - Pharmaceutical composition for treating wind-heat blood-heat type pruritus cutanea - Google Patents
Pharmaceutical composition for treating wind-heat blood-heat type pruritus cutanea Download PDFInfo
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- CN105943623A CN105943623A CN201610481102.9A CN201610481102A CN105943623A CN 105943623 A CN105943623 A CN 105943623A CN 201610481102 A CN201610481102 A CN 201610481102A CN 105943623 A CN105943623 A CN 105943623A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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Abstract
The invention discloses a pharmaceutical composition for treating wind-heat blood-heat type pruritus cutanea. The pharmaceutical composition is prepared from the following pharmaceutical raw materials in parts by weight: 16-20 parts of pseudo-ginseng, 14-16 parts of black ants, 3-5 parts of borneol, 3-5 parts of mint and 2-4 parts of eucalyptus oil. The pharmaceutical composition overcomes the disadvantages of conventional drugs for treating wind-heat blood-heat type pruritus cutanea, and the provided pharmaceutical composition for treating wind-heat blood-heat type pruritus cutanea is better in effect.
Description
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of medicine treating wind heat blood-heat type pruritus caused by wind pathogen
Compositions.
Background technology
Wind heat blood-heat type pruritus caused by wind pathogen, belongs to damp-heat type vulvitis.The situation of main cause wind syndrome due to dryness of blood, because
Old damage of essence insufficiency of blood, or long-term nutrition shortage, hemopoietic is not enough, or knot, fresh blood biochemical disorders in blood stasis
Caused.Its pathogenesis is the withered insufficiency of blood in Tianjin, loses caused by profit dryness-transformation.Characteristic of wind being concerned with mobility is the most easily itched.Skin scabies
Itch, eczema, body stock addiction, pruritus vulvae, vulvitis, nonspecific vaginitis and allergic dermatitis etc.
Dermatosis is commonly encountered diseases.In the ratio of human diseases, dermatosis patient occupies sizable ratio
Weight, shows have the people of more than 60% to suffer from dermatosis to varying degrees according to relevant information.
Current domestic with pure Chinese herbal and crude drugs preparations treat dermatosis, gynopathic medicine for external use, effect is preferable
Few in number.In clinic, there are many patients, affect trouble owing to can not get efficient Drug therapy
The physical and mental health of person and cause suffering, even cause unnecessary economic loss.Therefore, research and development
There is the dermatosis of significant curative effect, gynecology externally used pharmaceutical necessary, local in particular with Guangxi
Abundant Chinese herbal medicine resource, development, for releasing dermatosis and the sufferings of gynaecopathia patient, protect
Protect the healthy of the people, it is provided that effective pure Chinese medicinal preparation, it is contemplated that good social benefit can be produced
With significant economic benefit.
Summary of the invention
The technical problem to be solved in the present invention overcomes existing treatment wind heat blood-heat type pruritus caused by wind pathogen medicine
Not enough, it is provided that one treats the wind heat blood-heat type preferable pharmaceutical composition of pruritus caused by wind pathogen effect.
In pharmaceutical composition of the present invention, the consumption of each component is that inventor draws through a large amount of practice summaries
, it is made up of the crude drug of following weight parts:
Radix Notoginseng 16-20 part, Formica fusca 14-16 part, Borneolum Syntheticum 3-5 part, Herba Menthae 3-5 part, Oleum Eucalypti
2-4 part.
Preferably, it is made up of the crude drug of following weight parts:
18 parts of Radix Notoginseng, Formica fusca 15 parts, Borneolum Syntheticum 4 parts, Herba Menthae 4 parts, Oleum Eucalypti 3 parts.
The dosage form of pharmaceutical composition of the present invention can be that liniment, unguentum, lotion etc. medically can connect
The dosage form being subject to, their preparation method, supplementary product consumption are carried out by existing common process.
Pharmaceutical composition of the present invention is prepared the most in accordance with the following methods:
Above raw material, outside deicing sheet, Oleum Eucalypti, Herba Menthae is shredded, and extracts volatile oil with vapor distillation method,
It is standby that the another device of volatile oil seals cold preservation, medicinal residues;Medicinal residues and Radix Notoginseng, Formica fusca add 5-10 times of soak by water 2
Secondary, each 1-2 hour, collecting decoction filter, dense, let cool to relative density 1.03-1.10 it
Between, adding Oleum Eucalypti and the volatile oil of extraction, 5% ethyl hydroxybenzoate, stirring staticly settles mistake after 72 hours
Filter, filtrate subpackage, packs, checks, i.e. obtains lotion.
Present invention additionally comprises aforementioned pharmaceutical compositions in preparation treatment wind heat blood-heat type pruritus caused by wind pathogen medicine
Application.
In prescription of the present invention:
Radix Notoginseng, is a jewel in Chinese crude drug, remembers in Qing Dynasty's pharmaceutical texts supplementary Amplifications of the Compendium of Materia Medica
Carry: " ginseng qi-tonifying first, Radix Notoginseng enriches blood first, taste with and merit also etc., therefore claim Panax pseudoginseng, for
Most precious person in Chinese medicine." nature and flavor: sweet in the mouth;Micro-hardship;Warm in nature.Gui Jing: return Liver Channel;Stomach warp;
Heart channel;Lung meridian;Large intestine channel.Function: hemostasis;Dissipate blood;Analgesic therapy.Cure mainly: fall and flutter congestive edema, the thoracic obstruction
Angor, lump in the abdomen;Blood stasis amenorrhea;Dysmenorrhea;Puerperal, stasis of blood the moon was suffered from abdominal pain;Sore, carbuncle and painful swelling.Usage and dosage: decoct
Soup, 3-9 gram;Grind into powder, 1-3 gram;Or enter ball, dissipate.External: suitable reason, mill juice is coated with;Or grind into powder
Dress.Ecological environment: wild under the jungle of hillside, modern cultivates in the foot of the hill of height above sea level 800-1000m more
Tiltedly drape over one's shoulders, on mound gentle slope or under artificial cool canopy.Resource distribution: be distributed in Jiangxi, Hubei, Guangdong,
The ground such as Guangxi, Sichuan, Yunnan.Wild survivor is the most rare, mostly is cultivation.According to pharmaceutical analysis, Radix Notoginseng master
Contain six kinds of Saponins and sitosterol, daucosterol, flavone compound.Saponin is the main one-tenth of Radix Ginseng
Point, to physical strength reinforcing, improving Myocardial Oxygen Metabolism, the tolerance improving Animal Anoxia has effect very much.For
Monarch drug.
Formica fusca, Polyrhachis vicina Roger, formal name used at school is Polyhachis vicina Roger, and Formicidae is many
A kind of insecticide that thorn ant belongs to.Formica fusca treatment, health care, the method for health preserving, at me since being documented
Existing more than the 3000 year history of state and countries in the world.In Xishuangbanna of Yunnan is natural with the Tropical rain forest of its uniqueness
Geographical environment, has become the growth habitat of Polyhachis vicina Roger.Because the spy of Polyhachis vicina Roger living environment
Very, the medical value that it is special is created.Ant is treated, i.e. application Formica fusca is that people treat, keep healthy, support
Raw, it is simply that with balanced nutritious, balance body, treating different diseases with the same therapeutic principle, the medicine food of Formica fusca (Polyhachis vicina Roger)
Dual-purpose speciality, merges Formica fusca nourishing the human Body, strengthening spleen, tonifying kidney, dredge the meridian passage, benefiting QI for activating blood circulation, two-way
Regulation immunity, antiviral, anti-inflammatory and antalgic calmness etc. function, anti-treatment rheumatism, rheumatoid, hepatitis B,
The deficient property difficult miscellaneous diseases such as cough with asthma, diabetes;Balanced nutritious balance body, improves immunity and gets rid of illness by force,
Improve endurance resisting fatigue sexual function improving, health care's effect such as slow down aging.For ministerial drug.
Borneolum Syntheticum, acrid in the mouth is bitter, cool in nature.Function causing resuscitation with aromatic drugs, clearing away heat to alleviate pain.With the merit of its heat radiation pain relieving,
Therefore for diseases such as various skin pyogenic infection scabies.In the compound recipe of many external erosion prevention and muscle growings, it is often fitted with this product.Existing
Show for pharmacological research: its pharmacological action is similar to Camphora: higher concentration has bacteriostasis.Mucosa and
Subcutaneous tissue the most easily absorbs.For adjuvant drug.
Herba Menthae, it is pungent cool property sweating antipyretic medicine, external can training the mind dysmenorrhoea, skin pruritus, erythra and
Eczema etc..Main component volatile oil, Herba Menthae contains menthol, have antisepsis and sterilization, antiinflammatory, pain relieving,
The effect such as antipruritic.For adjuvant drug.
Oleum Eucalypti, for myrtle Eucalyptus globulus Labill Eucalyptus globulus Labill., Lauraceae
Plant Camphor tree Cinnamomum camphora (L.) Sieb. or above-mentioned two section belongs to other plant warp together
The volatile oil that steam distillation obtains.Wind-expelling pain-stopping.For skin pruritus, neuralgia.For making medicine.
Prescription of the present invention, according to traditional Chinese medical science pharmacology, selects folk remedy and department of dermatologry, gynecological to commonly use
Chinese medicine, medical herbs, form through many experiments screening.We are by 17 taste Chinese medicines and medical herbs groups such as Caulis Loniceraes
Become, side in Radix Notoginseng heat-clearing and toxic substances removing, dispelling wind dredging collateral, unsting: Formica fusca expelling wind and removing dampness, dissipating blood stasis analgesic therapy,
Antiinflammatory;Borneolum Syntheticum clearing away heat to alleviate pain;Herba Menthae, antisepsis and sterilization, antiinflammatory, pain relieving, antipruritic;Oleum Eucalypti, dispels the wind
Pain relieving.All medicines share, and have heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, removing dampness and killing parasites, effect of antipruritic pain relieving,
For skin pruritus, pruritus vulvae and eczema, scabies, tinea manus and pedis it can also be used to cleaning vagina,
Prevention is infected.
Detailed description of the invention
With specific embodiment, the invention will be further described below, but the invention is not limited in these
Embodiment.
Embodiment 1
Radix Notoginseng 160g, Formica fusca 160g, Borneolum Syntheticum 30g, Herba Menthae 50g, Oleum Eucalypti 20g.
Above raw material, outside deicing sheet, Oleum Eucalypti, Herba Menthae is shredded, and extracts volatile oil with vapor distillation method,
It is standby that the another device of volatile oil seals cold preservation, medicinal residues;Medicinal residues and Radix Notoginseng, Formica fusca add 5-10 times of soak by water 2
Secondary, each 1-2 hour, collecting decoction filter, dense, let cool to relative density 1.03-1.10 it
Between, add Oleum Eucalypti and the volatile oil of extraction, and add adjuvant, mixing, obtain liniment.
Embodiment 2
Radix Notoginseng 200g, Formica fusca 140g, Borneolum Syntheticum 50g, Herba Menthae 30g, Oleum Eucalypti 40g.
Above raw material, outside deicing sheet, Oleum Eucalypti, Herba Menthae is shredded, and extracts volatile oil with vapor distillation method,
It is standby that the another device of volatile oil seals cold preservation, medicinal residues;Medicinal residues and Radix Notoginseng, Formica fusca add 5-10 times of soak by water 2
Secondary, each 1-2 hour, collecting decoction filter, dense, let cool to relative density 1.03-1.10 it
Between, add Oleum Eucalypti and the volatile oil of extraction, and add adjuvant, mixing, obtain unguentum.
Embodiment 3
Radix Notoginseng 180g, Formica fusca 150g, Borneolum Syntheticum 40g, Herba Menthae 40g, Oleum Eucalypti 30g.
Above raw material, outside deicing sheet, Oleum Eucalypti, Herba Menthae is shredded, and extracts volatile oil with vapor distillation method,
It is standby that the another device of volatile oil seals cold preservation, medicinal residues;Medicinal residues and Radix Notoginseng, Formica fusca add 5-10 times of soak by water 2
Secondary, each 1-2 hour, collecting decoction filter, dense, let cool to relative density 1.03-1.10 it
Between, adding Oleum Eucalypti and the volatile oil of extraction, 5% ethyl hydroxybenzoate, stirring staticly settles mistake after 72 hours
Filter, filtrate subpackage, packs, checks, i.e. obtains liniment.
Experimental example: the embodiment of the present invention 3 treats wind heat blood-heat type pruritus caused by wind pathogen clinical observation on the therapeutic effect:
1. case selection
All meet tcm diagnosis standard, that dialectical genus wind heat blood-heat type pruritus caused by wind pathogen patient can include observation in is right
As.
2. diagnostic criteria
2.1 tcm diagnosis standards
Typically with year the lighter for many, sick genus newly rises, and as the warmest in bedding can causing shows effect or make pruritus add
Play, yellow and thin fur, rolling pulse or sliding number.
2.2 Western medicine diagnose standards
2.2.1 only have pruritus during onset, there is no any constitutional erythra, can be general and limitation.
2.2.2 paroxysmal pruritus, often based on night, often affects sleep, often feelings because of pruritus
Thread is exciting.Temperature changes, drinks or eats maror induction and becomes to increase the weight of.
2.2.3 there are the Secondary cases skin lesion such as scratch, blood crusts, pigmentation, eczematization, lichenification time.
3. exclusion standard (including inadaptation or rejecting standard)
3.1 belong to scabies, grain itch, louse disease, local neurodermatitis, diabetes, yellow cellulitis, interior
The pruritus that secretion hinders, nephritis, celiosite etc. cause.
3.2 ages, gestation or women breast-feeding their children, to this medicine allergy at under-18s or over-65s
Person.
3.3 are associated with severe primary disease, the psychotics such as cardiovascular, Liver and kidney and hemopoietic system.
3.4 do not meet inclusive criteria, not by regulation medication, it is impossible to judge curative effect or the congruent shadow of data
Ring curative effect or safety judgement person.
4. observational technique
Observe 80 examples altogether, be randomly divided into 2 groups, wherein treatment group 50 example, use embodiment 3 liniment;
Matched group 30 example, uses " JIEERYIN " washing liquid (production of Chengdu En Shiheng pharmaceutical Co. Ltd).
Usage: being directly coated with by medicinal liquid and put on the skin in affected part, day is coated with 3 times, is used in conjunction 7 days.
Conventional before test experimenter is made detailed physical examination, all meet case selection standard person and can receive
Enter the object of observation.After test the 3rd, 7 days each with examining 1 time, the record state of an illness and side effect.Use integration
Method evaluation therapeutic effect.Symptom and sign grading and scoring criteria refer to " observation table ".Curative effect is sentenced
Break and directly made by observer.Without other medicines during observation.
Before test, experimenter is made gynecologial examination by routine, takes vaginal secretions and makees microscopy, meets
Case selection standard person can include the object of observation in.Terminate Hou Jizuo gynecological the course for the treatment of and vaginal secretions shows
Micro mirror is checked.Therapeutic effect is evaluated by integration method.Symptom and sign grading and scoring criteria refer to " see
Examine table ".Outcome measure is directly made by observer.Other medicines are disabled during observation.
5. result
The significance witnessing integration difference before and after 5.1 wind heat blood-heat type pruritus caused by wind pathogen treatments compares (t inspection)
Table 1
All there is significant difference (P < 0.01)
6. the comparison of liang group curative effect of medication
Table 2
The curative effect of two kinds of diseases be there was no significant difference (P > 0.05) by two groups of medicines
7. untoward reaction and toxic and side effects
During 80 example checkings, there is untoward reaction and toxic and side effects in none example.
8. discuss
Its card integration and sign before and after the treatment of wind heat blood-heat type pruritus caused by wind pathogen are all had aobvious by 8.1 liang of group medicines
Write sex differernce (P < 0.01), say, that the sings and symptoms of two kinds of diseases is all had aobvious by two kinds of medicines
The improvement result (being shown in Table 2) write.
8.2 liang of group medicines all have curative effect relatively to disease, but there was no significant difference between group
(P>0.05)。
9. conclusion
9.1 the results show, embodiment 3 liniment has dispelling wind for relieving itching really, the merit of removing damp-heat
Effect, is all significantly improved effect to the clinical symptoms of wind heat blood-heat type pruritus caused by wind pathogen.
9.2 embodiment 3 liniments have higher curative effect to wind heat blood-heat type pruritus caused by wind pathogen, and its total effective rate is
96.00%, it is suitable for the medicine for treatment of disease, curative effect is affirmative.
During 9.3 checkings, there is untoward reaction and toxic and side effects in none example, illustrates that embodiment 3 liniment faces
Bed application is safe and reliable, and dosage form is also rational.
As a comparison, present invention applicant is the most respectively to Radix Notoginseng, Formica fusca folk prescription, and Radix Notoginseng and black
Contrast test has been done in the combination of Formica fusca, experimental result show the effect of prescription of the present invention considerably beyond more than
Contrast experiment's effect.
Claims (3)
1. the pharmaceutical composition treating wind heat blood-heat type pruritus caused by wind pathogen, it is characterised in that: this medicine
Compositions is made up of the crude drug of following weight parts:
Radix Notoginseng 16-20 part, Formica fusca 14-16 part, Borneolum Syntheticum 3-5 part, Herba Menthae 3-5 part, Oleum Eucalypti
2-4 part.
The pharmaceutical composition for the treatment of wind heat blood-heat type pruritus caused by wind pathogen the most according to claim 1, its
It is characterised by: this pharmaceutical composition is made up of the crude drug of following weight parts:
18 parts of Radix Notoginseng, Formica fusca 15 parts, Borneolum Syntheticum 4 parts, Herba Menthae 4 parts, Oleum Eucalypti 3 parts.
3. the pharmaceutical composition according to any one of claim 1-2 is at preparation treatment wind heat blood-heat type
Application in the medicine of pruritus caused by wind pathogen.
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107854564A (en) * | 2017-12-11 | 2018-03-30 | 阜阳市平衡医疗保健器械有限公司 | A kind of medicine for treating pruitus and preparation method thereof |
CN108096283A (en) * | 2017-12-29 | 2018-06-01 | 广西壮族自治区中医药研究院 | Polyhachis vicina Roger extract is as the purposes for preparing prevention itch drug |
-
2016
- 2016-06-24 CN CN201610481102.9A patent/CN105943623A/en active Pending
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107854564A (en) * | 2017-12-11 | 2018-03-30 | 阜阳市平衡医疗保健器械有限公司 | A kind of medicine for treating pruitus and preparation method thereof |
CN108096283A (en) * | 2017-12-29 | 2018-06-01 | 广西壮族自治区中医药研究院 | Polyhachis vicina Roger extract is as the purposes for preparing prevention itch drug |
CN108096283B (en) * | 2017-12-29 | 2020-08-07 | 广西壮族自治区中医药研究院 | Application of polyrhachis vicina Roger extract in preparation of medicine for preventing and treating pruritus |
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