CN103479712B - Traditional Chinese medicine composition for treating coronary heart disease angina and application thereof - Google Patents
Traditional Chinese medicine composition for treating coronary heart disease angina and application thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for treating coronary heart disease angina. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 7-13 parts of frankincense, 17-23 parts of lignum dalbergiae odoriferae, 7-13 parts of panax pseudoginseng and 2-8 parts of borneol. The invention also provides an application of the traditional Chinese medicine composition in treating coronary heart disease angina. The traditional Chinese medicine composition provided by the invention belongs to a traditional Chinese medicine compound preparation, and the compatibility meets the principle of chief, deputy, assistant and envoy of the traditional Chinese medicine. According to the verification of a pharmacodynamic experiment, the traditional Chinese medicine composition has a perfect curative effect on a patient suffering coronary heart disease angina, and a new method is provided for treating coronary heart disease angina. By applying the traditional Chinese medicine composition to acupuncture points, the medicine is absorbed by the skin and stimulates the meridians and acupuncture points, and the interference and degradation effects of the first-pass effect of the liver and gastrointestinal tract factors as well as possible toxic and side effects caused by oral administration of the medicine are avoided, thus the traditional Chinese medicine composition has a perfect application prospect.
Description
[technical field]
Field of medicaments of the present invention specifically, is a kind of Chinese medicine composition for the treatment of angina pectoris.
[background technology]
Coronary heart disease is called for short coronary heart disease.Refer to that, because lipid metabolism is abnormal, the lipid in blood is calm on the endarterium of otherwise smooth, pile up at the lipid material of some similar medicated porridge samples of endarterium and form white speckle, be called atherosclerotic lesion.These specklees gradually increase and cause lumen of artery narrow, blood flow is obstructed, causes heart ischemia, produce angina pectoris.
The Etiological of coronary heart disease is coronary atherosclerosis, but atherosclerotic reason still imperfectly understands, and may be the result of many factors comprehensive function.Think that this pathogenetic risk factor has: age and sex (male of more than 45 years old, more than 55 years old or postclimacteric women), (father and elder brothers are before 55 years old for family history, mother/sister died from heart disease before 65 years old), dyslipidemia (low-density lipoprotein cholesterol LDL-C is too high, and HDL-C HDL-C is too low), hypertension, glucose in urine is sick, smoking, overweight, fat, gout, does not move.
Chinese patent literature CN101036769 discloses a kind of medicament and preparation method for the treatment of angina pectoris, the prescription of this preparation: the medicine compositions such as invention Radix Ginseng, Radix Notoginseng, the Radix Astragali, Flos Carthami, Radix Salviae Miltiorrhizae, Rhizoma Corydalis.Chinese patent literature CN1403144 discloses one and has blood circulation promoting and blood stasis dispelling, the Chinese medicine preparation of regulating QI to relieve pain effect, said preparation is made up of Chinese medicines such as Rhizoma Chuanxiong, Radix Paeoniae Rubra, Semen Persicae, Flos Carthami, Radix Bupleuri, Fructus Aurantiis, can add medicine acceptable carrier if desired, said preparation is used for the anginal treatment of cardiovascular stasis coronary heart disease.But about utilize clinically Olibanum, Lignum Dalbergiae Odoriferae, Radix Notoginseng, borneol composition Acupoint Application in Treating angina pectoris method yet there are no report.The present inventor once used Lignum Santali Albi, Lignum Dalbergiae Odoriferae, Radix Notoginseng, Borneolum Syntheticum as basic prescription to treat angina pectoris, but to draw materials difficulty due to Lignum Santali Albi, expensive, added treatment cost.The present inventor has invented Olibanum, Lignum Dalbergiae Odoriferae, Radix Notoginseng, Borneolum Syntheticum further as basic prescription to treat angina pectoris, and because Olibanum is drawn materials easily, cost ratio Lignum Santali Albi is cheaply a lot, significantly can reduce drug expenditure, and improves curative effect.
[summary of the invention]
The object of the invention is for deficiency of the prior art, a kind of Chinese medicine composition for the treatment of angina pectoris is provided.
Of the present invention again one object be that a kind of application for the treatment of the Chinese medicine composition of angina pectoris is provided.
For achieving the above object, the technical scheme that the present invention takes is: a kind of Chinese medicine composition of angina pectoris, and described Chinese medicine composition is made up of the crude drug of following weight portion: Olibanum 7 ~ 13 parts, Lignum Dalbergiae Odoriferae 17 ~ 23 parts, Radix Notoginseng 7 ~ 13 parts, Borneolum Syntheticum 2 ~ 8 parts.
The present invention is made up of the component of following parts by weight: Olibanum 8 ~ 11 parts, Lignum Dalbergiae Odoriferae 19 ~ 21 parts, Radix Notoginseng 7 ~ 13 parts, Borneolum Syntheticum 4 ~ 6 parts.
The present invention is made up of the component of following parts by weight: Olibanum 9 ~ 10 parts, Lignum Dalbergiae Odoriferae 19 ~ 20 parts, Radix Notoginseng 9 ~ 11 parts, Borneolum Syntheticum 4 ~ 5 parts.
The present invention is made up of the component of following parts by weight: Olibanum 10 parts, Lignum Dalbergiae Odoriferae 20 parts, Radix Notoginseng 10 parts, Borneolum Syntheticum 5 parts.
For realizing above-mentioned second object, the technical scheme that the present invention takes is: described Chinese medicine composition is in the application for the treatment of angina pectoris.
The invention has the advantages that: treatment angina pectoris medicine belongs to compound Chinese medicinal preparation, and its compatibility meets Chinese medicine " monarch " principle, and through pharmacodynamic experiment checking, this medicine significantly can reduce the angina pectoris of patient, improves patient sign.Radix Notoginseng in treatment angina pectoris medicine, Olibanum have and have promoting blood circulation to remove blood stasis, the effect of promoting the circulation of QI to relieve pain.Lignum Dalbergiae Odoriferae has the effect of blood circulation promoting competent silt pain relieving, and Borneolum Syntheticum can reduce decreased heart rate, the effect of arteriovenous oxygen difference.Therefore, medicine of the present invention reduces toxic and side effects in conjunction with acupoint application therapy while raising curative effect.Originally toxic and side effects of applying ointment or plaster is little, is suitable for life-time service, is that one treats treating coronary heart disease and angina pectoris safely and effectively.
[detailed description of the invention]
The detailed description of the invention that note and application thereof are applied in the acupuncture point obtained a kind of composition of medicine for the treatment of angina pectoris provided by the invention below elaborates.
embodiment 1
the preparation one for the treatment of angina pectoris medicine
1, with Olibanum 7 parts, Lignum Dalbergiae Odoriferae 23 parts, Radix Notoginseng 7 parts, Borneolum Syntheticum 8 parts of ratio modulation
2, medicine is dried, pulverize, cross 80-120 mesh sieve, for subsequent use
The more dry paste of crude drug powder maltose furnishing is got, the same day system that medicine should use when 3, sticking
Or it is for subsequent use to put cold compartment of refrigerator.
embodiment 2
the preparation two for the treatment of angina pectoris medicine
1, with Olibanum 13 parts, Lignum Dalbergiae Odoriferae 17 parts, Radix Notoginseng 13 parts, Borneolum Syntheticum 2 parts of ratio modulation
2, medicine is dried, pulverize, cross 80-120 mesh sieve, for subsequent use
The more dry paste of crude drug powder maltose furnishing is got, the same day system that medicine should use when 3, sticking
Or it is for subsequent use to put cold compartment of refrigerator.
embodiment 3
the preparation three for the treatment of angina pectoris medicine
1, with Olibanum 8 parts, Olibanum 21 parts, Radix Notoginseng 7 parts, Borneolum Syntheticum 6 parts of ratio modulation
2, medicine is dried, pulverize, cross 80-120 mesh sieve, for subsequent use
The more dry paste of crude drug powder maltose furnishing is got, the same day system that medicine should use when 3, sticking
Or it is for subsequent use to put cold compartment of refrigerator.
embodiment 4
the preparation four for the treatment of angina pectoris medicine
1, with Olibanum 10 parts, Lignum Dalbergiae Odoriferae 20 parts, Radix Notoginseng 10 parts, Borneolum Syntheticum 5 parts of ratio modulation
2, medicine is dried, pulverize, cross 80-120 mesh sieve, for subsequent use
The more dry paste of crude drug powder maltose furnishing is got, the same day system that medicine should use when 3, sticking
Or it is for subsequent use to put cold compartment of refrigerator.
embodiment 5
the preparation five for the treatment of angina pectoris medicine
1, with Olibanum 11 parts, Lignum Dalbergiae Odoriferae 19 parts, Radix Notoginseng 13 parts, Borneolum Syntheticum 4 parts of ratio modulation
2, medicine is dried, pulverize, cross 80-120 mesh sieve, for subsequent use
The more dry paste of crude drug powder maltose furnishing is got, the same day system that medicine should use when 3, sticking
Or it is for subsequent use to put cold compartment of refrigerator.
embodiment 6
the preparation six for the treatment of angina pectoris medicine
1, with Olibanum 9 parts, Lignum Dalbergiae Odoriferae 20 parts, Radix Notoginseng 9 parts, Borneolum Syntheticum 5 parts of ratio modulation
2, medicine is dried, pulverize, cross 80-120 mesh sieve, for subsequent use
The more dry paste of crude drug powder maltose furnishing is got, the same day system that medicine should use when 3, sticking
Or it is for subsequent use to put cold compartment of refrigerator.
embodiment 7
the preparation seven for the treatment of angina pectoris medicine
1, with Olibanum 10 parts, Lignum Dalbergiae Odoriferae 19 parts, Radix Notoginseng 11 parts, Borneolum Syntheticum 4 parts of ratio modulation
2, medicine is dried, pulverize, cross 80-120 mesh sieve, for subsequent use
The more dry paste of crude drug powder maltose furnishing is got, the same day system that medicine should use when 3, sticking
Or it is for subsequent use to put cold compartment of refrigerator.
embodiment 8
the preparation eight for the treatment of angina pectoris medicine
1, with Olibanum 7 parts, Lignum Dalbergiae Odoriferae 21 parts, Radix Notoginseng 13 parts, Borneolum Syntheticum 6 parts of ratio modulation
2, medicine is dried, pulverize, cross 80-120 mesh sieve, for subsequent use
The more dry paste of crude drug powder maltose furnishing is got, the same day system that medicine should use when 3, sticking
Or it is for subsequent use to put cold compartment of refrigerator.
embodiment 9
the preparation nine for the treatment of angina pectoris medicine
1, with Olibanum 8 parts, Lignum Dalbergiae Odoriferae 17 parts, Radix Notoginseng 11 parts, Borneolum Syntheticum 2 parts of ratio modulation
2, medicine is dried, pulverize, cross 80-120 mesh sieve, for subsequent use
The more dry paste of crude drug powder maltose furnishing is got, the same day system that medicine should use when 3, sticking
Or it is for subsequent use to put cold compartment of refrigerator.
embodiment 10
the preparation ten for the treatment of angina pectoris medicine
1, with Olibanum 10 parts, Lignum Dalbergiae Odoriferae 23 parts, Radix Notoginseng 12 parts, Borneolum Syntheticum 2 parts of ratio modulation
2, medicine is dried, pulverize, cross 80-120 mesh sieve, for subsequent use
The more dry paste of crude drug powder maltose furnishing is got, the same day system that medicine should use when 3, sticking
Or it is for subsequent use to put cold compartment of refrigerator.
embodiment 11
the preparation 11 for the treatment of angina pectoris medicine
1, with Olibanum 13 parts, Lignum Dalbergiae Odoriferae 17 parts, Radix Notoginseng 11 parts, Borneolum Syntheticum 8 parts of ratio modulation
2, medicine is dried, pulverize, cross 80-120 mesh sieve, for subsequent use
The more dry paste of crude drug powder maltose furnishing is got, the same day system that medicine should use when 3, sticking
Or it is for subsequent use to put cold compartment of refrigerator.
embodiment 12
the preparation 12 for the treatment of angina pectoris medicine
1, with Olibanum 13 parts, Lignum Dalbergiae Odoriferae 17 parts, Radix Notoginseng 9 parts, Borneolum Syntheticum 2 parts of ratio modulation
2, medicine is dried, pulverize, cross 80-120 mesh sieve, for subsequent use
The more dry paste of crude drug powder maltose furnishing is got, the same day system that medicine should use when 3, sticking
Or it is for subsequent use to put cold compartment of refrigerator.
embodiment 13
pharmacodynamic studyone, materials and methods
1.1 experiment material
1.1.1 medical material
Isosorbide mononitrate slow releasing capsule (the limited production of the general Pharmaceutical in the rising sun East Sea, Shanghai)
Spectinomycin hydrochloride (trade name: Gin Kgo Plus; Xinyi, Shanghai Gin Kgo Plus pharmaceutical Co. Ltd produces)
Nitroglycerin solid buccal tablets
1.1.1 patient
Inclusive criteria will be met and be divided into 4 groups for the treatment of groups and 1 group of each 35 example of matched group at random the outpatient service of Zhabei District in Shanghai institute of traditional Chinese medicine cardiovascular diseases traditional Chinese medical science Pivot Subjects, the 175 routine patients that are in hospital year April in October, 2010-2011.Treatment group 35 example, chooses man 17 example, female 18 example, 50 ~ 77 years old age, average (62.29 ± 7.79) year; The course of disease 1.0 ~ 16.5 years, average (9.03 ± 4.62) year; Wherein old myocardial infarction 10 example, unstable angina pectoris 18 example, complicated hypertension 9 example, hyperlipemia 17 example, diabetes 5 example.Matched group 35 example, man 18 example, female 17 example, 49 ~ 78 years old age, average (64.03 ± 8.04) year; The course of disease 1.5 ~ 17 years, average (9.48 ± 4.53) year; Wherein old myocardial infarction 9 example, unstable angina pectoris 19 example, complicated hypertension 10 example, hyperlipemia 18 example, diabetes 4 example.Treatment group and matched group patient all without significant difference, have comparability in age, sex, the course of disease, merging disease etc.
1.2 experimental technique
1.2.1 western medicine routine treatment: five groups all to give isosorbide mononitrate slow releasing capsule (the limited production of the general Pharmaceutical in the rising sun East Sea, Shanghai) 40mg oral, once a day; Unstable angina patient tartarize metoprolol (trade name: Gin Kgo Plus; Xinyi, Shanghai Gin Kgo Plus pharmaceutical Co. Ltd produces) 25 mg are oral, every day 2 times; Angina pectoris attacks person adds and uses nitroglycerin sublingual administration; Complicated hypertension is sick, glycosuria patient maintains former medication.
1.2.2 Acupoint Application in Treating: treatment group adds carries out point application with applying ointment or plaster.Apply ointment or plaster respectively with the modulation of the formula of embodiment 1, embodiment 4, embodiment 8 and embodiment 12, and medicine is dried, pulverize, cross 80-120 mesh sieve, for subsequent use.Treatment group 1(embodiment 1), treatment group 2(embodiment 4), treatment group 3(embodiment 8), treatment group 4(embodiment 12) patient used apply ointment or plaster treat time get the more dry paste of crude drug powder maltose furnishing, the preparation on the same day that medicine should use, or it is for subsequent use to put cold compartment of refrigerator.Medicine preparation process requires to carry out under aseptic, clean, normal temperature environment.Acupoint selection: interior pass, chien shih, tsu san li, rich and prosperous, all gets bilateral.Applying method: first will stick position 75% ethanol or povidone iodine routine disinfection, then 1 centimetre, cut-off footpath, the medicine cake of height 0.5 cm, is affixed on medicine on acupuncture point, fixes with the medical proof fabric of 5 cm x 5 centimetres.Within every 2 days, change 1 time, within 2 weeks, be 1 course for the treatment of.
1.3 Testing index,
1.3.1 health giving quality observation index
1.3.1.1 observe tcm syndrome before and after treatment group and matched group improve situation comprise cardiopalmus, chest pain, uncomfortable in chest, breathe hard, dirty and greasy fur or cunning, rolling pulse.
1.3.1.2 correlated observation test item treatment group and matched group all before and after treatment early morning on an empty stomach get ulnar vein blood and detect.
1.3.1.3 peripheral blood hemorheology index and Fibrinogen (Fg):
1.3.2 safety observation index
1.3.2.1 blood, urine, stool routine examination and hepatic and renal function before and after patient treatment are checked.
1.3.2.2 the untoward reaction situation during recording medicine.
1.3.3 curative effect determinate standard is all with reference to " new Chinese medicine guideline of clinical investigations ".
1.3.3.1 tcm syndrome efficacy assessment standard is effective: clinical symptoms, sign are obviously improved, syndrome integral Jian Shao≤70 %; Effective: clinical symptoms, sign all take a favorable turn, syndrome integral reduces by 30 % ~ 70 %(containing 30%); Invalid: clinical symptoms, sign are not improved, even increase the weight of, syndrome integral reduces < 30 %; Increase the weight of: clinical symptoms, sign all have and increase the weight of, before after treatment, syndrome integral exceedes treatment.
1.3.3.2 curative effect to treat angina pectoris evaluation criteria is effective: the cardinal symptom such as angina pectoris disappears or reaches effective standard, and electrocardiogram returns to normal ECG or reaches roughly normal (i.e. normal range electrocardiogram); Effective: to reach effective standard after the cardinal symptoms such as angina pectoris alleviate, electrocardiogram improvement reaches effective standard; Invalid: the cardinal symptoms such as angina pectoris are without improvement, and electrocardiogram is substantially identical with before treatment; Increase the weight of: the cardinal symptoms such as angina pectoris and electrocardiogram increase the weight of before comparatively testing.
1.3.3.3 ECG curative effect evaluation criteria is effective: electrocardiogram returns to " roughly normal " (i.e. " normal range ") or reach " normal ECG "; Effective: the reduction of S-T section, to treat rear more than rise 0.05mV, but the normal level do not arrived, shoal (reaching more than 25% person) at the negative T wave that mainly leads; Or T ripple becomes uprightly from smooth, chamber or intraventricular block improver; Invalid: electrocardiogram is substantially identical with before treatment; Increase the weight of: S-T section reduces more than 0.05mV before comparatively treating, cause T ripple to deepen (reaching more than 25%) or upright T ripple flattens smooth mainly leading, smooth T ripple becomes to be inverted, and occurs ectopic cardiac rhythm, atrioventricular block or intraventricular block.
1.4 statistical method are respectively organized measured value and are all adopted
± S represents, enumeration data adopts χ
2inspection, measurement data adopts t inspection.
Two, result
2.1 tcm syndrome curative effect (see table 1) result displays, treatment group tcm syndrome curative effect is better than matched group (P<0.01).
Table 1 tcm syndrome comparitive study
Treatment group and matched group tcm syndrome comparitive study * P<0.01
Conclusion: the treatment group of applying after note treatment through acupuncture point as can be seen from Table 1 found with comparing of matched group, clinical symptoms, the sign for the treatment of group all have greatly improved, illustrate through point application to treatment angina pectoris successful, wherein with treatment group 2(embodiment 4) therapeutic effect the most remarkable.
2.2 curative effect to treat angina pectoris (see table 2) result shows, and treatment group tcm syndrome curative effect is better than matched group (P<0.05).
Table 2 curative effect to treat angina pectoris compares
Treatment group and matched group curative effect to treat angina pectoris compare * * P<0.05
Conclusion: the treatment group of applying after note treatment through acupuncture point as can be seen from Table 2 found with comparing of matched group, clinical symptoms, the sign for the treatment of group all have greatly improved, illustrate through point application to treatment angina pectoris successful, wherein with treatment group 2(embodiment 4) therapeutic effect the most remarkable.
2.3 ECG curative effect (see table 3) result shows, and treatment group tcm syndrome curative effect is better than matched group (P<0.01).
Conclusion: the treatment group of applying after note treatment through acupuncture point as can be seen from Table 3 found with comparing of matched group, clinical symptoms, the sign for the treatment of group all have greatly improved, illustrate through point application to treatment angina pectoris successful, wherein with treatment group 2(embodiment 4) therapeutic effect the most remarkable.
The comparison of 2.4 peripheral blood hemorheology indexs and Fg
The change of table 4 hemorheology and Fg
Conclusion: can find out that treatment group and matched group are in the change occurred before and after treatment by table, clinical symptoms, the sign for the treatment of group all have greatly improved, illustrate through point application to treatment angina pectoris successful, wherein with treatment group 2(embodiment 4) therapeutic effect the most remarkable.
embodiment 14
therapeutic effect parallel laboratory test
One, materials and methods
1.2 experiment material
1.1.1 medical material
Isosorbide mononitrate slow releasing capsule (the limited production of the general Pharmaceutical in the rising sun East Sea, Shanghai)
Spectinomycin hydrochloride (trade name: Gin Kgo Plus; Xinyi, Shanghai Gin Kgo Plus pharmaceutical Co. Ltd produces)
Nitroglycerin solid buccal tablets
1.1.1 patient
The routine patient of Treating Patients of Angina Pectoris 280 choosing clinical definite is divided into 8 groups at random, each 35 examples.Treatment group 35 example, man 17 example, female 18 example, 50 ~ 77 years old age, average (62.29 ± 7.79) year; The course of disease 1.0 ~ 16.5 years, average (9.03 ± 4.62) year; Wherein old myocardial infarction 10 example, unstable angina pectoris 18 example, complicated hypertension 9 example, hyperlipemia 17 example, diabetes 5 example.Matched group 35 example, man 18 example, female 17 example, 49 ~ 78 years old age, average (64.03 ± 8.04) year; The course of disease 1.5 ~ 17 years, average (9.48 ± 4.53) year; Wherein old myocardial infarction 9 example, unstable angina pectoris 19 example, complicated hypertension 10 example, hyperlipemia 18 example, diabetes 4 example.Each group of patient all without significant difference, has comparability in age, sex, the course of disease, merging disease etc.
1.2 experimental technique
1.2.1 western medicine routine treatment: each group all to give isosorbide mononitrate slow releasing capsule (the limited production of the general Pharmaceutical in the rising sun East Sea, Shanghai) 40mg oral, once a day; Unstable angina patient tartarize metoprolol (trade name: Gin Kgo Plus; Xinyi, Shanghai Gin Kgo Plus pharmaceutical Co. Ltd produces) 25 mg are oral, every day 2 times; Angina pectoris attacks person adds and uses nitroglycerin sublingual administration; Complicated hypertension is sick, glycosuria patient maintains former medication.
1.2.2 Acupoint Application in Treating: treatment group adds carries out point application with applying ointment or plaster.Apply ointment or plaster No. 1 (embodiment 1) and No. 2 (7 parts, the Lignum Santali Albis that apply ointment or plaster, Lignum Dalbergiae Odoriferae 23 parts, Radix Notoginseng 7 parts, Borneolum Syntheticum 8 parts of ratio modulation, concrete grammar is see embodiment 1), apply ointment or plaster No. 3 (embodiments 4) and No. 4 (10 parts, the Lignum Santali Albis that apply ointment or plaster, Lignum Dalbergiae Odoriferae 20 parts, Radix Notoginseng 10 parts, Borneolum Syntheticum 5 parts of ratio modulation, concrete grammar is see embodiment 4), apply ointment or plaster No. 5 (embodiments 8) and No. 6 (7 parts, the Lignum Santali Albis that apply ointment or plaster, Lignum Dalbergiae Odoriferae 21 parts, Radix Notoginseng 13 parts, Borneolum Syntheticum 6 parts of ratio modulation, concrete grammar is see embodiment 8), apply ointment or plaster No. 7 (embodiments 12) and No. 8 (13 parts, the Lignum Santali Albis that apply ointment or plaster, Lignum Dalbergiae Odoriferae 17 parts, Radix Notoginseng 9 parts, Borneolum Syntheticum 2 parts of ratio modulation, concrete grammar is see embodiment 12).Eight kinds of important set composite medicines are dried, pulverizes, cross 80-120 mesh sieve, for subsequent use, respectively 35 patients are treated.Get crude drug powder maltose furnishing more dry paste when sticking, the preparation on the same day that medicine should use, or it is for subsequent use to put cold compartment of refrigerator.
1.3 Testing index
1.3.1 health giving quality observation index
1.3.1.1 observe each group treatment before and after tcm syndrome improve situation comprise cardiopalmus, chest pain, uncomfortable in chest, breathe hard, dirty and greasy fur or cunning, rolling pulse.
1.3.1.2 correlated observation test item respectively organize all before and after treatment early morning on an empty stomach get ulnar vein blood and detect.
1.3.1.3 peripheral blood hemorheology index and Fibrinogen (Fg):
1.3.2 safety observation index
1.3.2.1 blood, urine, stool routine examination and hepatic and renal function before and after patient treatment are checked.
1.3.2.2 the untoward reaction situation during recording medicine.
1.3.3 curative effect determinate standard is all with reference to " new Chinese medicine guideline of clinical investigations "
(2).
1.3.3.1 tcm syndrome efficacy assessment standard is effective: clinical symptoms, sign are obviously improved, syndrome integral Jian Shao≤70 %; Effective: clinical symptoms, sign all take a favorable turn, syndrome integral reduces by 30 % ~ 70 %(containing 30%); Invalid: clinical symptoms, sign are not improved, even increase the weight of, syndrome integral reduces < 30 %; Increase the weight of: clinical symptoms, sign all have and increase the weight of, before after treatment, syndrome integral exceedes treatment.
1.3.3.2 curative effect to treat angina pectoris evaluation criteria is effective: the cardinal symptom such as angina pectoris disappears or reaches effective standard, and electrocardiogram returns to normal ECG or reaches roughly normal (i.e. normal range electrocardiogram); Effective: to reach effective standard after the cardinal symptoms such as angina pectoris alleviate, electrocardiogram improvement reaches effective standard; Invalid: the cardinal symptoms such as angina pectoris are without improvement, and electrocardiogram is substantially identical with before treatment; Increase the weight of: the cardinal symptoms such as angina pectoris and electrocardiogram increase the weight of before comparatively testing.
1.3.3.3 ECG curative effect evaluation criteria is effective: electrocardiogram returns to " roughly normal " (i.e. " normal range ") or reach " normal ECG "; Effective: the reduction of S-T section, to treat rear more than rise 0.05mV, but the normal level do not arrived, shoal (reaching more than 25% person) at the negative T wave that mainly leads; Or T ripple becomes uprightly from smooth, chamber or intraventricular block improver; Invalid: electrocardiogram is substantially identical with before treatment; Increase the weight of: S-T section reduces more than 0.05mV before comparatively treating, cause T ripple to deepen (reaching more than 25%) or upright T ripple flattens smooth mainly leading, smooth T ripple becomes to be inverted, and occurs ectopic cardiac rhythm, atrioventricular block or intraventricular block.
1.4 statistical method are respectively organized measured value and are all adopted
± S represents, enumeration data adopts χ
2inspection, measurement data adopts t inspection.
Two, result
2.1 tcm syndrome curative effect (see table 5) (P<0.01)
Table 5 tcm syndrome comparitive study
Each group of tcm syndrome comparitive study * P<0.01
Conclusion: can find out that the Chinese medicine composition of preparing burden with Olibanum is applied ointment or plaster by table and to compare with the clinical symptoms after the Chinese medicine composition application therapy of preparing burden with Lignum Santali Albi, sign, illustrate that the former therapeutic effect is better than the therapeutic effect of the latter.
2.2 curative effect to treat angina pectoris (see table 6) (P<0.05)
Table 6 curative effect to treat angina pectoris compares
Each group of curative effect to treat angina pectoris compares * * P<0.05
Conclusion: can find out that the Chinese medicine composition of preparing burden with Olibanum is applied ointment or plaster by table and to compare with the clinical symptoms after the Chinese medicine composition application therapy of preparing burden with Lignum Santali Albi, sign, illustrate that the former therapeutic effect is better than the therapeutic effect of the latter.
2.3 ECG curative effect (see table 7) (P<0.01).
Table 7 ECG curative effect compares
Conclusion: can find out that the Chinese medicine composition of preparing burden with Olibanum is applied ointment or plaster by table and to compare with the clinical symptoms after the Chinese medicine composition application therapy of preparing burden with Lignum Santali Albi, sign, illustrate that the former therapeutic effect is better than the therapeutic effect of the latter.
The comparison of 2.4 peripheral blood hemorheology indexs and Fg
The change of table 8 hemorheology and Fg
Conclusion: can find out that the Chinese medicine composition of preparing burden with Olibanum is applied ointment or plaster by table and to compare with the clinical symptoms after the Chinese medicine composition application therapy of preparing burden with Lignum Santali Albi, sign, illustrate that the former therapeutic effect is better than the therapeutic effect of the latter.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the prerequisite not departing from the inventive method; can also make some improvement and supplement, these improve and supplement and also should be considered as protection scope of the present invention.
Claims (6)
1. treat a Chinese medicine composition for angina pectoris, it is characterized in that described Chinese medicine composition is made up of the crude drug of following weight portion: Olibanum 7 ~ 13 parts, Lignum Dalbergiae Odoriferae 17 ~ 23 parts, Radix Notoginseng 7 ~ 13 parts, Borneolum Syntheticum 2 ~ 8 parts.
2. Chinese medicine composition according to claim 1, is characterized in that, described Chinese medicine composition is made up of the crude drug of following weight portion: Olibanum 8 ~ 11 parts, Lignum Dalbergiae Odoriferae 19 ~ 21 parts, Radix Notoginseng 9 ~ 12 parts, Borneolum Syntheticum 4 ~ 6 parts.
3. Chinese medicine composition according to claim 1, is characterized in that, described Chinese medicine composition is made up of the crude drug of following weight portion: Olibanum 9 ~ 10 parts, Lignum Dalbergiae Odoriferae 19 ~ 20 parts, Radix Notoginseng 9 ~ 11 parts, Borneolum Syntheticum 4 ~ 5 parts.
4. Chinese medicine composition according to claim 1, is characterized in that, described Chinese medicine composition is made up of the crude drug of following weight portion: Olibanum 10 parts, Lignum Dalbergiae Odoriferae 20 parts, Radix Notoginseng 10 parts, Borneolum Syntheticum 5 parts.
5., according to the arbitrary described medicine of claim 1-4, it is characterized in that, the medicament of described medicine is cream solid medicament.
6. according to the application of the arbitrary described Chinese medicine composition of claim 1-4 in preparation treatment treating coronary heart disease and angina pectoris.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310338617.XA CN103479712B (en) | 2013-08-06 | 2013-08-06 | Traditional Chinese medicine composition for treating coronary heart disease angina and application thereof |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1583015A (en) * | 2004-06-11 | 2005-02-23 | 刘国英 | Chinese medicine for angina pectoris and preventing from diseases of cerebral blood vessels and its preparation |
| CN1857395A (en) * | 2006-03-17 | 2006-11-08 | 崔彬 | Compound Chinese medicine composition for treating cardiac and cerebral vascular diseases |
| CN1857393A (en) * | 2006-03-09 | 2006-11-08 | 杨文龙 | Capsule for treating myocardial strain, angina pectoris and arteriosclerosis and its preparing method |
| CN101439066A (en) * | 2007-11-22 | 2009-05-27 | 天津天士力制药股份有限公司 | Chinese medicine granular containing notoginseng extract and preparation method thereof |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1583015A (en) * | 2004-06-11 | 2005-02-23 | 刘国英 | Chinese medicine for angina pectoris and preventing from diseases of cerebral blood vessels and its preparation |
| CN1857393A (en) * | 2006-03-09 | 2006-11-08 | 杨文龙 | Capsule for treating myocardial strain, angina pectoris and arteriosclerosis and its preparing method |
| CN1857395A (en) * | 2006-03-17 | 2006-11-08 | 崔彬 | Compound Chinese medicine composition for treating cardiac and cerebral vascular diseases |
| CN101439066A (en) * | 2007-11-22 | 2009-05-27 | 天津天士力制药股份有限公司 | Chinese medicine granular containing notoginseng extract and preparation method thereof |
Non-Patent Citations (2)
| Title |
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| 中药外治法防治冠心病心绞痛概况;张莉莉等;《中医外治杂志》;20090215;第18卷(第01期);49-51 * |
| 冠心病的中药透皮疗法研究;袁容容等;《浙江中西医结合杂志》;19971110;第07卷(第06期);382 * |
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