CN112451605B - Enema formula for treating spleen deficiency and damp-heat syndrome in active stage of chronic ulcerative colitis - Google Patents

Enema formula for treating spleen deficiency and damp-heat syndrome in active stage of chronic ulcerative colitis Download PDF

Info

Publication number
CN112451605B
CN112451605B CN202011413632.2A CN202011413632A CN112451605B CN 112451605 B CN112451605 B CN 112451605B CN 202011413632 A CN202011413632 A CN 202011413632A CN 112451605 B CN112451605 B CN 112451605B
Authority
CN
China
Prior art keywords
parts
ulcerative colitis
charcoal
damp
chronic ulcerative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN202011413632.2A
Other languages
Chinese (zh)
Other versions
CN112451605A (en
Inventor
党志博
李梦阁
党中勤
王宇亮
李波
许向前
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Henan Hospital Traditional Chinese Medicine Second Affiliated Hospital of Henan University of Traditional Chinese Medicine TCM
Original Assignee
Henan Hospital Traditional Chinese Medicine Second Affiliated Hospital of Henan University of Traditional Chinese Medicine TCM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Henan Hospital Traditional Chinese Medicine Second Affiliated Hospital of Henan University of Traditional Chinese Medicine TCM filed Critical Henan Hospital Traditional Chinese Medicine Second Affiliated Hospital of Henan University of Traditional Chinese Medicine TCM
Priority to CN202011413632.2A priority Critical patent/CN112451605B/en
Publication of CN112451605A publication Critical patent/CN112451605A/en
Application granted granted Critical
Publication of CN112451605B publication Critical patent/CN112451605B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/64—Insects, e.g. bees, wasps or fleas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/27—Asclepiadaceae (Milkweed family), e.g. hoya
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489—Sophora, e.g. necklacepod or mamani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708—Rheum (rhubarb)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/84—Valerianaceae (Valerian family), e.g. valerian
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/85—Verbenaceae (Verbena family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0031—Rectum, anus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Insects & Arthropods (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Husbandry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention discloses an enema formula for treating spleen deficiency and damp-heat syndrome in the active period of chronic ulcerative colitis, which mainly comprises tuckahoe, purslane, dahurian patrinia herb, paniculate swallowwort root, Chinese fevervine, folium callicarpae pedunculatae, gallnut, palm charcoal, rhubarb charcoal, sophora flower charcoal, crinis carbonisatus and dried alum; clinical researches show that the traditional Chinese medicine enema formula has the effects of tonifying spleen, clearing damp, clearing heat, detoxifying, stopping bleeding and treating dysentery, is remarkable in curative effect, convenient to apply, safe, reliable, easy to accept by patients and convenient to popularize clinically, and has very important clinical value for treating spleen deficiency and damp heat syndrome in active period of chronic ulcerative colitis based on traditional Chinese medicine syndrome differentiation.

Description

Enema formula for treating spleen deficiency and damp-heat syndrome in active stage of chronic ulcerative colitis
Technical Field
The invention relates to the field of chronic ulcerative colitis, in particular to an enema formula for treating spleen deficiency and damp-heat syndrome in an active period of chronic ulcerative colitis.
Background
Ulcerative colitis is an inflammatory bowel disease mainly invading the large intestine mucous membrane and submucosa, and is a disease represented by continuous or repeated attack diarrhea, mucopurulent bloody stool with abdominal pain, tenesmus and systemic symptoms of different degrees, the clinical repeated attack often extends to months or even years, and the existing therapeutic drugs for ulcerative colitis have the problems of high cost, repeated symptoms, unsatisfactory curative effect and the like of partial patients, so that no ideal drug for treating ulcerative colitis exists at present, and partial severe patients need to adopt comprehensive treatment measures such as operation and the like clinically.
Disclosure of Invention
Aiming at the defects of the existing medical treatment, the invention provides an enema formula for treating spleen deficiency and damp-heat syndrome in the active period of chronic ulcerative colitis.
In order to solve the technical problems, the invention adopts the technical scheme that:
an enema formula for treating spleen deficiency and damp-heat syndrome in an active period of chronic ulcerative colitis is prepared from the following raw materials in parts by weight: 5.0-7.0 parts of poria cocos, 5.0-7.0 parts of purslane, 3.5-5.5 parts of herba patriniae, 3.5-5.5 parts of paniculate swallowwort root, 3.5-5.5 parts of paederia scandens, 2.0-4.0 parts of folium callicarpae pedunculatae, 2.0-4.0 parts of Chinese gall, 2.0-4.0 parts of palm charcoal, 2.0-4.0 parts of rhubarb charcoal, 2.0-4.0 parts of sophora japonica charcoal, 2.0-4.0 parts of crinis carbonisatus and 2.0-4.0 parts of dried alum.
Preferably, the enema formula for treating spleen deficiency and damp-heat syndrome in the active period of chronic ulcerative colitis is prepared from the following raw materials in parts by weight: 5.5-6.5 parts of poria cocos, 5.5-6.5 parts of purslane, 4.0-5.0 parts of herba patriniae, 4.0-5.0 parts of paniculate swallowwort root, 4.0-5.0 parts of paederia scandens, 2.5-3.5 parts of folium callicarpae pedunculatae, 2.5-3.5 parts of gallnut, 2.5-3.5 parts of palm charcoal, 2.5-3.5 parts of rhubarb charcoal, 2.5-3.5 parts of sophora japonica charcoal, 2.5-3.5 parts of crinis carbonisatus and 2.5-3.5 parts of dried alum.
Preferably, the enema formula for treating spleen deficiency and damp-heat syndrome in the active period of chronic ulcerative colitis is prepared from the following raw materials in parts by weight: 6.0 parts of poria cocos, 6.0 parts of purslane, 4.5 parts of patrinia, 4.5 parts of cynanchum paniculatum, 4.5 parts of paederia scandens, 3.0 parts of callicarpa bodinieri, 3.0 parts of gallnut, 3.0 parts of palm charcoal, 3.0 parts of rhubarb charcoal, 3.0 parts of sophora flower charcoal, 3.0 parts of crinis carbonisatus and 3.0 parts of dried alum.
Preferably, in the enema formula for treating spleen deficiency and damp-heat syndrome in the active period of chronic ulcerative colitis, the weight parts of the raw materials are 10g per 1 part.
The preparation method of the enema formula for treating spleen deficiency and damp-heat syndrome in the active period of chronic ulcerative colitis comprises the following steps:
weighing raw material components of each medicine according to parts by weight, cleaning, drying and crushing;
secondly, adding the smashed mixed raw materials into a marmite or a stainless steel pan, adding water to submerge the medicine surface, soaking for 60 minutes, heating and boiling for 60 minutes, filtering to obtain decoction, adding water into medicine residues, decocting for 60 minutes again, combining the decoction obtained in the two times, standing, filtering out precipitates, taking 200mL of the medicine liquid, subpackaging the medicine liquid into 250mL of infusion bottles, and sterilizing at 115 ℃ for 40 minutes to obtain the traditional Chinese medicine enema formula for treating chronic ulcerative colitis; or
A YFY13/3A type medicine decocting machine is adopted, 3-6 doses of medicine raw materials are filled into a disposable filter bag, 1000mL of water is mixed with one dose of medicine for soaking for 30 minutes, then the medicine is sealed for decocting for 30 minutes, decoction is filtered out, and the decoction is sealed into 200mL of liquid medicine per bag under the aseptic condition, so that the traditional Chinese medicine enema formula for treating chronic ulcerative colitis is obtained.
The application of the enema formula for treating the spleen deficiency and damp-heat syndrome in the active period of chronic ulcerative colitis is 200mL each time, the enema is kept 2 times a day, and the enema is stopped for 1 day after 14 days of continuous enema.
The formula is as follows: according to the problems of repeated symptoms, poor curative effect and high cost of treatment medicines of the existing chronic ulcerative colitis patients, the traditional Chinese medicine enema formula is developed by years of clinical trials and referring to a large amount of evidence-based medical data, and clinical research and observation show that the traditional Chinese medicine enema formula has better antidiarrheal and hemostatic effects. The enema prescription is selected for the administration route, just as the principle of external treatment, i.e. internal treatment, described in Ji '28729Zhou-Wen' of Ming Dynasty famous medical Wu-Shi. … … the externally-applied medicine, i.e. the internally-applied medicine … … ", is mainly the same in the way of external application and internal application, and the internally-applied medicine can also be absorbed by external enema to act.
And (3) composition analysis: the traditional Chinese medicine enema formula for treating spleen deficiency and damp-heat syndrome in the active period of chronic ulcerative colitis, disclosed by the invention, has the effects of tonifying spleen and excreting dampness, clearing away heat and toxic materials, stopping bleeding and treating dysentery by using purslane as main medicines; herba Patriniae has effects of clearing away heat and toxic materials, resolving carbuncle and relieving pain, radix Cynanchi Paniculati has effects of removing toxic substances and detumescence, dispelling pathogenic wind and relieving pain, herba Paederiae has effects of invigorating stomach and relieving pain, removing toxic substances and treating dysentery, folium Callicarpae Formosanae has effects of astringing and stopping bleeding, clearing heat and removing toxic substances, and the four are adjuvant principal drugs, which are ministerial drugs together; galla chinensis, used as adjuvant drugs, has effects of astringing intestine to stop diarrhea, and astringing to stop bleeding, and is prepared from fortune Windmillpalm charcoal, crinis Carbonisatus charcoal, Sophora flower charcoal, and rhubarb charcoal; dried alum is used as a guiding drug for drying dampness, checking diarrhea and stopping bleeding. The whole formula is combined to play the roles of strengthening spleen and eliminating dampness, clearing heat and detoxicating, and stopping bleeding and treating dysentery.
The invention has the beneficial effects that:
1. the traditional Chinese medicine enema formula disclosed by the invention has a unique curative effect in the treatment of the active period of chronic ulcerative colitis, and through retention enema, on one hand, the medicine can directly act on intestinal mucosa to play the roles of clearing heat and removing toxicity, stopping bleeding and treating dysentery, and on the other hand, the medicine can be absorbed by the intestinal mucosa and can also act on the spleen and stomach, so that the functions of adjusting viscera and strengthening spleen and clearing damp are achieved.
2. The traditional Chinese medicine retention enema can enable the medicine to directly reach the focus, improves the local medicine concentration, avoids the first-pass elimination effect of oral administration, reduces liver metabolism, reduces the stimulation to the stomach, reduces toxic and side effects, and achieves the effects of cleaning the intestinal tract, removing the necrotic tissue, promoting granulation, astringing to stop bleeding, recovering the barrier function of the intestinal mucosa and regulating the intestinal flora. The traditional Chinese medicine enema can directly enter blood after being absorbed by intestinal mucosa, promotes blood circulation, enhances digestive function, has the functions of strengthening spleen and excreting dampness, detoxifying and stopping bleeding, stopping diarrhea and treating dysentery, accelerates the recovery of ulcerative colitis, and overcomes the defect that the curative effect of part of patients is not good because of long-term oral administration of medicines.
3. The traditional Chinese medicine enema formula disclosed by the invention has the effects of tonifying spleen, clearing damp, clearing heat, removing toxicity, stopping bleeding and treating dysentery, the clinical effective rate is more than 90%, the medicine sources are sufficient, the processing and the preparation are easy, the application is convenient, no drug resistance or adverse reaction occurs, the clinical medicine effect can be better exerted, and the medicine risk of patients with ulcerative colitis is reduced.
4. The traditional Chinese medicine enema formula disclosed by the invention is remarkable in curative effect, simple and convenient to operate, safe and reliable, easy to accept by patients, convenient to popularize clinically and very important in clinical value for treating ulcerative colitis.
Detailed Description
The technical solutions of the present invention are further described in detail with reference to specific examples so that those skilled in the art can better understand the present invention and can implement the present invention, but the examples are not intended to limit the present invention.
Example 1
An enema formula for treating spleen deficiency and damp-heat syndrome in an active period of chronic ulcerative colitis is prepared from the following raw materials in parts by weight: 5.0 parts of tuckahoe, 5.0 parts of purslane, 3.5 parts of herba patriniae, 3.5 parts of paniculate swallowwort root, 3.5 parts of Chinese fevervine, 2.0 parts of callicarpa bodinieri leaf, 2.0 parts of gallnut, 2.0 parts of palm charcoal, 2.0 parts of rhubarb charcoal, 2.0 parts of sophora flower charcoal, 2.0 parts of crinis carbonisatus and 2.0 parts of dried alum.
The preparation method of the enema formula for treating spleen deficiency and damp-heat syndrome in the active period of chronic ulcerative colitis comprises the following steps:
weighing raw material components of each medicine according to the parts by weight, cleaning, drying and crushing;
secondly, adding the smashed mixed raw materials into a marmite or a stainless steel pot, adding water to submerge the medicine surface, soaking for 60 minutes, heating and boiling for 60 minutes, filtering out decoction, adding water into medicine dregs, decocting for 1 hour again, combining the decoction of the two times, standing, filtering out precipitates, taking 200mL of medicine liquid, subpackaging into 250mL of infusion bottles, and sterilizing at 115 ℃ for 40 minutes to obtain the traditional Chinese medicine enema formula for treating chronic ulcerative colitis.
Example 2
An enema formula for treating spleen deficiency and damp-heat syndrome in an active period of chronic ulcerative colitis is prepared from the following raw materials in parts by weight: 5.5 parts of tuckahoe, 5.5 parts of purslane, 4.0 parts of herba patriniae, 4.0 parts of paniculate swallowwort root, 4.0 parts of Chinese fevervine herb, 2.5 parts of callicarpa bodinieri leaf, 2.5 parts of gallnut, 2.5 parts of palm charcoal, 2.5 parts of rhubarb charcoal, 2.5 parts of sophora flower charcoal, 2.5 parts of crinis carbonisatus and 2.5 parts of dried alum.
The preparation method of the enema formula for treating spleen deficiency and damp-heat syndrome in the active period of chronic ulcerative colitis comprises the following steps:
weighing raw material components of each medicine according to the parts by weight, cleaning, drying and crushing;
secondly, adding the smashed mixed raw materials into a marmite or a stainless steel pan, adding water to submerge the surface of the raw materials, soaking for 60 minutes, heating and boiling for 60 minutes, filtering to obtain decoction, adding water to the decoction dregs of a decoction, decocting for 60 minutes again, combining the decoction obtained in two times, standing, filtering out precipitates, taking 200mL of the decoction, subpackaging the decoction into 250mL of infusion bottles, and sterilizing at 115 ℃ for 40 minutes to obtain the traditional Chinese medicine enema formula for treating chronic ulcerative colitis.
Example 3
An enema formula for treating spleen deficiency and damp-heat syndrome in an active period of chronic ulcerative colitis is prepared from the following raw materials in parts by weight: 6.0 parts of poria cocos, 6.0 parts of purslane, 4.5 parts of patrinia, 4.5 parts of cynanchum paniculatum, 4.5 parts of paederia scandens, 3.0 parts of callicarpa bodinieri, 3.0 parts of gallnut, 3.0 parts of palm charcoal, 3.0 parts of rhubarb charcoal, 3.0 parts of sophora flower charcoal, 3.0 parts of crinis carbonisatus and 3.0 parts of dried alum.
The preparation method of the enema formula for treating spleen deficiency and damp-heat syndrome in the active period of chronic ulcerative colitis comprises the following steps:
weighing raw material components of each medicine according to the parts by weight, cleaning, drying and crushing;
secondly, adding the smashed mixed raw materials into a marmite or a stainless steel pan, adding water to submerge the surface of the raw materials, soaking for 60 minutes, heating and boiling for 60 minutes, filtering to obtain decoction, adding water to the decoction dregs of a decoction, decocting for 60 minutes again, combining the decoction obtained in two times, standing, filtering out precipitates, taking 200mL of the decoction, subpackaging the decoction into 250mL of infusion bottles, and sterilizing at 115 ℃ for 40 minutes to obtain the traditional Chinese medicine enema formula for treating chronic ulcerative colitis.
Example 4
An enema formula for treating spleen deficiency and damp-heat syndrome in an active period of chronic ulcerative colitis is prepared from the following raw materials in parts by weight: 6.5 parts of poria cocos, 6.5 parts of purslane, 5.0 parts of patrinia, 5.0 parts of cynanchum paniculatum, 5.0 parts of paederia scandens, 3.5 parts of callicarpa bodinieri, 3.5 parts of gallnut, 3.5 parts of palm charcoal, 3.5 parts of rheum officinale charcoal, 3.5 parts of sophora flower charcoal, 3.5 parts of crinis carbonisatus and 3.5 parts of dried alum.
The preparation method of the enema formula for treating spleen deficiency and damp-heat syndrome in the active period of chronic ulcerative colitis comprises the following steps:
weighing raw material components of each medicine according to the parts by weight, cleaning, drying and crushing;
secondly, adding the smashed mixed raw materials into a marmite or a stainless steel pot, adding water to submerge the medicine surface, soaking for 60 minutes, heating and boiling for 60 minutes, filtering out decoction, adding water into medicine dregs for decocting for 60 minutes again, combining the decoction of the two times, standing, filtering out precipitates, taking 200mL of medicine liquid, subpackaging into 250mL of infusion bottles, and sterilizing at 115 ℃ for 40 minutes to obtain the traditional Chinese medicine enema formula for treating chronic ulcerative colitis.
Example 5
An enema formula for treating spleen deficiency and damp-heat syndrome in an active period of chronic ulcerative colitis is prepared from the following raw materials in parts by weight: 7.0 parts of poria cocos, 7.0 parts of purslane, 5.5 parts of patrinia, 5.5 parts of cynanchum paniculatum, 5.5 parts of paederia scandens, 4.0 parts of callicarpa bodinieri, 4.0 parts of gallnut, 4.0 parts of palm charcoal, 4.0 parts of rhubarb charcoal, 4.0 parts of sophora flower charcoal, 4.0 parts of crinis carbonisatus and 4.0 parts of dried alum.
The preparation method of the enema formula for treating spleen deficiency and damp-heat syndrome in the active period of chronic ulcerative colitis comprises the following steps:
weighing raw material components of each medicine according to the parts by weight, cleaning, drying and crushing;
and secondly, taking more than 4 doses of the medicinal raw materials, filling the crushed mixed raw materials into a disposable filter bag, putting the disposable filter bag into a YFY13/3A type decocting machine, mixing and soaking the medicinal raw materials for 30 minutes in 1000mL of water, then carrying out closed decoction for 30 minutes, filtering the decoction after the completion, and sealing the decoction into 200mL of liquid medicine per bag under the aseptic condition to obtain the traditional Chinese medicine enema formula for treating the chronic ulcerative colitis.
Clinical efficacy experiment
The clinical effect observation of the traditional Chinese medicine enema formula prepared by the invention is as follows:
1. general data
(1) Inclusion criteria were: the Western medicine diagnosis refers to the consensus opinion on the diagnosis and treatment standard of inflammatory bowel disease in China (2012) formulated by the Cooperation group of the digestive disease society of the Chinese medical society, and routine examination of liver function, kidney function, blood, urine and feces has no obvious abnormality in the last 1 year. The syndrome differentiation of the traditional Chinese medicine accords with the syndrome of ulcerative colitis and spleen deficiency and dampness-heat, and the traditional Chinese medicine diagnosis standard refers to the consensus opinion of traditional Chinese medicine diagnosis and treatment experts of ulcerative colitis (2017) formulated by the spleen and stomach disease division of the Chinese medical society.
(2) Exclusion criteria: patients with severe ulcerative colitis, intestinal occupancy and other serious complications; ② pregnant or lactating women; severe liver and kidney insufficiency, malignant tumor and incapability of tolerating general anesthesia as evaluated by an anesthesiologist; patients with cardiovascular and cerebrovascular diseases; patients with other immune and organ failure diseases are combined; sixthly, the patients with psychosis are combined; seventhly, other serious infectious diseases such as pulmonary tuberculosis and HIV positive patients are combined; and ninthly, people allergic to various medicines participate in other clinical testers within 3 months.
(3) Case selection: the selection meets the inclusion standard and belongs to the diagnosis standard of Western medicine chronic ulcerative colitis, the disease stage is active stage, the disease degree is mild and moderate, 66 patients with spleen deficiency and dampness-heat syndrome are identified in Chinese medicine, and 33 patients are randomly divided into an observation group and a control group. In the observation group 33, 1 male was dropped, and the remaining 32 male were 18 female; age (37.68 + -10.52). In the control group 33, 1 female was dropped, and the remaining 32 cases were 19 male and 12 female; age (38.26 ± 9.75) years.
2. Method of treatment
(1) Control group: conventional treatment in western medicine: mesalazine enteric coated tablet (0.25 g per tablet, manufactured by sunflower pharmaceutical group Jia Mus Luling pharmaceutical Co., Ltd., national Standard H19980148), 1g per time, 4 times daily, is orally administered.
(2) Observation group: on the basis of the treatment of a control group, a traditional Chinese medicine retention enema formula is added, 200mL of the enema is used every time, 2 times are taken every day, 1 time is changed every 4 weeks after the treatment, the enema is retained, and the rest is carried out for 1 day after 14 days of continuous enema. The sausage filling method comprises the following steps: the temperature of the enema liquid is preferably (39 +/-0.5) DEG C, the left lateral decubitus position is firstly taken, the buttocks are fully exposed, a treatment towel is paved, the buttocks are lifted by about 10cm, the front end of an anal tube is lubricated, the anal tube is inserted into the rectum by 15cm, and the administration speed of the enema is adjusted according to the tolerance condition of a patient, and is usually 80 drops/min. And (3) posture adjustment: if the rectum, sigmoid colon and left half colon are ulcerated, the left lateral decubitus is taken, and the retention time of the enema is prolonged as much as possible; if the ulcer surface is extensive or affects the whole colon, the left lateral decubitus, the horizontal decubitus and the right lateral decubitus are sequentially taken for 20min, and then the patient is rested in a comfortable position.
(3) The course of treatment is as follows: the treatment period is 1 treatment course for 8 weeks in both groups.
3. Standard of therapeutic effect
(1) Comprehensive therapeutic effect evaluation standard
Clinical cure: the symptom sign disappears, and the abdominal pain, diarrhea, purulent bloody stool completely disappears; the absolute score for the endoscopic sub-score was 0 or 1 for the Mayo score.
The effect is shown: the symptoms are obviously relieved, and the abdominal pain, diarrhea, purulent bloody stool are obviously relieved; the total Mayo score is less than or equal to 2 points and no single subentry score is more than 1 point.
Improvement: the symptoms are relieved, and the bellyache, the diarrhea and the purulent bloody stool relatively disappear; the Mayo score decreased endoscopic sub-score by at least 1 point relative to baseline.
And (4) invalidation: if the above criteria are not met, the disease condition is not improved or worsened.
(2) Evaluation criteria of syndrome therapeutic effect
Refer to the clinical research principles of New Chinese medicine published by the publishing agency of Chinese medical science and technology in 5 months in 2002
Clinical cure: the symptoms and physical signs disappear or basically disappear, and the syndrome score is reduced by more than or equal to 95 percent.
The effect is shown: the symptoms and physical signs are obviously improved, and the syndrome integral is reduced by more than or equal to 70 percent.
The method has the following advantages: the symptoms and physical signs are obviously improved, and the syndrome integral is reduced by more than or equal to 30 percent.
And (4) invalidation: the symptoms and physical signs are not obviously improved or even aggravated, and the syndrome integral is reduced by less than 30 percent.
The calculation formula (nimodipine method) is: [ (before treatment integration-after treatment integration) ÷ before treatment integration ] × 100%
(3) The evaluation of the curative effect of the enteroscopy inflammation refers to the consensus opinion of traditional Chinese medicine diagnosis and treatment experts of ulcerative colitis (2017), and an improved Mayo activity index is adopted.
The clinical effect is as follows: the total Mayo score is reduced by more than or equal to 30 percent or more than or equal to 3 points from the baseline level, and meanwhile, the hematochezia sub-score is reduced by more than or equal to 1 point or the absolute score of the hematochezia sub-score is 0 or 1.
Clinical remission: the total Mayo score is less than or equal to 2 points and no single subentry score is more than 1 point.
Endoscope response: the Mayo score decreased endoscopic sub-score by at least 1 point relative to baseline.
And (3) mucosa healing: the absolute score for the endoscopic sub-score was 0 or 1 for the Mayo score.
4. Statistical method
Data were processed using SPSS19.0 statistical analysis software. The measured data are expressed as (x + -s), and the comparison between groups adopts t test (or corrects t test); the count data are expressed as percentages and the comparisons between groups are by x 2 Checking; the grade data is tested by rank sum H, and the difference with P less than 0.05 has significance statistics.
5. Results
(1) The two groups of the composition have a combined therapeutic effect, which is shown in Table 1
TABLE 1 comparison of the comprehensive therapeutic effects of the observed group and the control group [ case (%) ]
Figure BDA0002818081250000061
Note: compared with the curative effect of the control group, the difference has significant statistical significance (P is less than 0.05)
In 32 cases of an observation group, 11 cases are clinically cured, 14 cases are obviously effective, 5 cases are effective, 2 cases are ineffective, and the total effective rate is 93.75%; in 32 cases of the control group, 8 cases are clinically cured, 12 cases are obviously effective, 7 cases are effective, 5 cases are ineffective, and the total effective rate is 84.38%. Through statistical treatment, the curative effect of the treatment group is obviously better than that of the control group (P is less than 0.05).
(2) The two syndromes are compared in terms of efficacy, as shown in Table 2
TABLE 2 comparison of the syndrome therapeutic effects of the observation group and the control group [ case (%) ]
Figure BDA0002818081250000071
Note: compared with the curative effect of a control group, the difference has significant statistical significance (P is less than 0.05).
In 32 observation groups, 12 cases are clinically cured, 14 cases are obviously effective, 5 cases are effective, 1 case is ineffective, and the total effective rate is 96.88%; in 32 cases of the control group, 9 cases are clinically cured, 12 cases are obviously effective, 7 cases are effective, 4 cases are ineffective, and the total effective rate is 87.50%. Through statistical treatment, the curative effect of the treatment group is obviously better than that of the control group (P is less than 0.05).
(3) Comparison of endoscope response rates before and after two groups of treatments, see Table 3
TABLE 3 comparison of the results of the enteroscopy before and after the two groups of treatments [ case (%) ]
Figure BDA0002818081250000072
Note: compared with the curative effect of a control group, the difference has significant statistical significance.
(4) Comparison of Mayo score improvement before and after treatment in two groups, see Table 4
TABLE 4 comparison of Mayo score improvement before and after treatment (x + -s)
Figure BDA0002818081250000073
Note: comparison with this group before treatment: ＊ p is less than 0.01; comparison with control group after treatment: △ P＜0.05。
6. and (4) adverse reaction observation: no obvious adverse reaction occurred in both groups of patients.
The above description is only a preferred embodiment of the present invention, and not intended to limit the scope of the present invention, and all modifications of equivalent structures and equivalent processes, which are made by the present specification, or directly or indirectly applied to other related technical fields, are included in the scope of the present invention.

Claims (6)

1. An enema composition for treating spleen deficiency and damp-heat syndrome in the active period of chronic ulcerative colitis is characterized by being prepared from the following traditional Chinese medicine raw materials in parts by weight: 5.0-7.0 parts of poria cocos, 5.0-7.0 parts of purslane, 3.5-5.5 parts of herba patriniae, 3.5-5.5 parts of paniculate swallowwort root, 3.5-5.5 parts of paederia scandens, 2.0-4.0 parts of folium callicarpae pedunculatae, 2.0-4.0 parts of Chinese gall, 2.0-4.0 parts of palm charcoal, 2.0-4.0 parts of rhubarb charcoal, 2.0-4.0 parts of sophora japonica charcoal, 2.0-4.0 parts of crinis carbonisatus and 2.0-4.0 parts of dried alum.
2. The enema composition for treating spleen deficiency and dampness-heat syndrome in the active period of chronic ulcerative colitis according to claim 1, wherein the traditional Chinese medicine raw materials in parts by weight are as follows: 5.5-6.5 parts of poria cocos, 5.5-6.5 parts of purslane, 4.0-5.0 parts of herba patriniae, 4.0-5.0 parts of paniculate swallowwort root, 4.0-5.0 parts of paederia scandens, 2.5-3.5 parts of folium callicarpae pedunculatae, 2.5-3.5 parts of gallnut, 2.5-3.5 parts of palm charcoal, 2.5-3.5 parts of rhubarb charcoal, 2.5-3.5 parts of sophora japonica charcoal, 2.5-3.5 parts of crinis carbonisatus and 2.5-3.5 parts of dried alum.
3. The enema composition for treating spleen deficiency and dampness-heat syndrome in the active period of chronic ulcerative colitis according to claim 1, wherein the traditional Chinese medicine raw materials in parts by weight are as follows: 6.0 parts of poria cocos, 6.0 parts of purslane, 4.5 parts of patrinia, 4.5 parts of cynanchum paniculatum, 4.5 parts of paederia scandens, 3.0 parts of callicarpa bodinieri, 3.0 parts of gallnut, 3.0 parts of palm charcoal, 3.0 parts of rhubarb charcoal, 3.0 parts of sophora flower charcoal, 3.0 parts of crinis carbonisatus and 3.0 parts of dried alum.
4. The enema composition for treating spleen deficiency and damp-heat syndrome in the active period of chronic ulcerative colitis according to any one of claims 1 to 3, wherein the raw materials are 10g in parts by weight per 1 part.
5. A method for preparing the enema composition for treating spleen deficiency and damp-heat syndrome during active period of chronic ulcerative colitis according to claim 1, comprising the steps of:
weighing raw material components of each medicine according to parts by weight, cleaning, drying and crushing;
secondly, adding the smashed mixed raw materials into a marmite or a stainless steel pan, adding water to submerge the surface of the raw materials, soaking for 60 minutes, heating and boiling for 60 minutes, filtering to obtain decoction, adding water to the decoction dregs of a decoction, decocting for 60 minutes again, combining the decoction obtained in two times, standing, filtering out precipitates, taking 200mL of the decoction, subpackaging the decoction into 250mL of infusion bottles, and sterilizing at 115 ℃ for 40 minutes to obtain the traditional Chinese medicine enema composition for treating chronic ulcerative colitis; or adopting a YFY13/3A type medicine decocting machine, putting 3-6 doses of medicine raw materials into a disposable filter bag, mixing and soaking 1000mL of medicine in water for 30 minutes, then carrying out closed decoction for 30 minutes, filtering decoction, and sealing into 200mL of liquid medicine per bag under an aseptic condition to obtain the traditional Chinese medicine enema composition for treating chronic ulcerative colitis.
6. Use of the enema composition of any one of claims 1 to 4 or the enema composition prepared by the method of claim 5 in the preparation of a medicament for treating spleen deficiency and damp-heat syndrome during active stage of chronic ulcerative colitis.
CN202011413632.2A 2020-12-04 2020-12-04 Enema formula for treating spleen deficiency and damp-heat syndrome in active stage of chronic ulcerative colitis Active CN112451605B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202011413632.2A CN112451605B (en) 2020-12-04 2020-12-04 Enema formula for treating spleen deficiency and damp-heat syndrome in active stage of chronic ulcerative colitis

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202011413632.2A CN112451605B (en) 2020-12-04 2020-12-04 Enema formula for treating spleen deficiency and damp-heat syndrome in active stage of chronic ulcerative colitis

Publications (2)

Publication Number Publication Date
CN112451605A CN112451605A (en) 2021-03-09
CN112451605B true CN112451605B (en) 2022-08-09

Family

ID=74800133

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202011413632.2A Active CN112451605B (en) 2020-12-04 2020-12-04 Enema formula for treating spleen deficiency and damp-heat syndrome in active stage of chronic ulcerative colitis

Country Status (1)

Country Link
CN (1) CN112451605B (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101002927A (en) * 2007-01-25 2007-07-25 潘金火 Traditional Chinese medicine capsule for treating chronic ulcerosa colitis, its component and preparing method
CN104491420A (en) * 2014-11-25 2015-04-08 哈尔滨医科大学 Enema traditional Chinese medicinal composition for treating ulcerative colitis, and preparation method thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101837096B (en) * 2010-05-31 2012-06-06 牛菊萍 Enema medicament for curing ulcerative colitis
CN105250710A (en) * 2015-11-06 2016-01-20 刘杰 Traditional Chinese medicine enema for treating ulcerative colitis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101002927A (en) * 2007-01-25 2007-07-25 潘金火 Traditional Chinese medicine capsule for treating chronic ulcerosa colitis, its component and preparing method
CN104491420A (en) * 2014-11-25 2015-04-08 哈尔滨医科大学 Enema traditional Chinese medicinal composition for treating ulcerative colitis, and preparation method thereof

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
中药灌肠治疗溃疡性结肠炎32例;王正忠;《现代中医药》;20031231(第02期);第46页左栏第1、6段，右栏第5-10段 *
健脾清热利湿方保留灌肠联合西药治疗溃疡性结肠炎40例临床观察;田秀峰;《齐齐哈尔医学院学报》;20091231;第30卷(第20期);第2496页摘要，正文第1、2、4段，第2497页第2-3段 *
健脾清热除湿法治疗慢性结肠炎44例;张友安;《湖北中医杂志》;20021231;第24卷(第05期);全文 *
王正忠.中药灌肠治疗溃疡性结肠炎32例.《现代中医药》.2003,(第02期),第46页左栏第1、6段，右栏第5-10段. *
田秀峰.健脾清热利湿方保留灌肠联合西药治疗溃疡性结肠炎40例临床观察.《齐齐哈尔医学院学报》.2009,第30卷(第20期),第2496页摘要，正文第1、2、4段，第2497页第2-3段. *

Also Published As

Publication number Publication date
CN112451605A (en) 2021-03-09

Similar Documents

Publication Publication Date Title
CN102319350B (en) External scald oil medicinal composition for treating burns and scalds
CN102327478B (en) Pharmaceutical composition for treating burns and scalds and preparation method thereof
CN111991535B (en) Traditional Chinese medicine extract with function of treating helicobacter pylori-associated gastritis and preparation method and application thereof
CN111870681B (en) Traditional Chinese medicine composition for treating asthma and application thereof
CN101134065A (en) Traditional Chinese medicine for treating intestinal obstruction
CN112451605B (en) Enema formula for treating spleen deficiency and damp-heat syndrome in active stage of chronic ulcerative colitis
CN111481638A (en) Traditional Chinese medicine enema preparation for treating ulcerative colitis and preparation method thereof
CN111228367B (en) Traditional Chinese medicine external lotion for treating infantile anaphylactoid purpura and preparation method thereof
CN103655768B (en) Chinese medicine composition for the treatment of cold-dampness type knee osteoarthritis and preparation method thereof
CN111388551A (en) Traditional Chinese medicine composition for reducing fat, discharging turbidity and clearing intestines, application and preparation method thereof
CN103893701B (en) A kind of Chinese medicine composition alleviating patients suffering from postoperative pain and promote wound healing
CN113058024A (en) Traditional Chinese medicine composition and preparation method and application thereof
CN108524828B (en) Traditional Chinese medicine composition for treating ascites due to cirrhosis as well as preparation method and application thereof
CN108066706B (en) Traditional Chinese medicine jaundice-removing plaster for treating icteric hepatitis
CN106110124A (en) A kind of antituberculotic Chinese medicine composition
CN112274613A (en) Pharmaceutical composition for treating knee osteoarthritis
CN104547125A (en) Gastrointestinal drug and application thereof
CN101623432A (en) Application of jade lady variant decoction in preparing medicament for treating hyperthyrea symptom
CN105395975A (en) Enema traditional Chinese medicine composition treating ulcerative colitis and preparation method thereof
CN113633748B (en) Medicine for treating spontaneous bacterial peritonitis damp-heat stasis syndrome of liver cirrhosis and preparation method thereof
CN114699363B (en) Traditional Chinese medicine wax mud for osteoarthritis and preparation method thereof
CN115554374B (en) Traditional Chinese medicine composition for treating helicobacter pylori gastritis as well as preparation method and application thereof
CN112755157B (en) Liver-soothing and carbuncle-eliminating decoction compound for treating granulomatous mastitis in lump stage
CN105998256A (en) Medicament for treating urinary calculus and preparation method of medicament
CN103479712B (en) Traditional Chinese medicine composition for treating coronary heart disease angina and application thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
TA01 Transfer of patent application right

Effective date of registration: 20220526

Address after: No.6 Dongfeng Road, Jinshui District, Zhengzhou City, Henan Province

Applicant after: HENAN PROVINCE HOSPITAL OF TCM (THE SECOND AFFILIATED HOSPITAL OF HENAN University OF TCM)

Address before: Beijing University of traditional Chinese medicine, 11 North Third Ring Road East, Chaoyang District, Beijing 100020

Applicant before: Dang Zhibo

TA01 Transfer of patent application right
GR01 Patent grant
GR01 Patent grant