CN112451605A - Enema formula for treating spleen deficiency and damp-heat syndrome in active stage of chronic ulcerative colitis - Google Patents
Enema formula for treating spleen deficiency and damp-heat syndrome in active stage of chronic ulcerative colitis Download PDFInfo
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Abstract
The invention discloses an enema formula for treating spleen deficiency and damp-heat syndrome in the active period of chronic ulcerative colitis, which mainly comprises tuckahoe, purslane, dahurian patrinia herb, paniculate swallowwort root, Chinese fevervine, folium callicarpae pedunculatae, gallnut, palm charcoal, rhubarb charcoal, sophora flower charcoal, crinis carbonisatus and dried alum; clinical researches show that the traditional Chinese medicine enema formula has the effects of tonifying spleen, clearing damp, clearing heat, detoxifying, stopping bleeding and treating dysentery, is remarkable in curative effect, convenient to apply, safe, reliable, easy to accept by patients and convenient to popularize clinically, and has very important clinical value for treating spleen deficiency and damp heat syndrome in active period of chronic ulcerative colitis based on traditional Chinese medicine syndrome differentiation.
Description
Technical Field
The invention relates to the field of chronic ulcerative colitis, in particular to an enema formula for treating spleen deficiency and damp-heat syndrome in an active period of chronic ulcerative colitis.
Background
Ulcerative colitis is an inflammatory bowel disease mainly invading the large intestine mucous membrane and submucosa, and is a disease represented by continuous or repeated attack diarrhea, mucopurulent bloody stool with abdominal pain, tenesmus and systemic symptoms of different degrees, the clinical repeated attack often extends to months or even years, and the existing therapeutic drugs for ulcerative colitis have the problems of high cost, repeated symptoms, unsatisfactory curative effect and the like of partial patients, so that no ideal drug for treating ulcerative colitis exists at present, and partial severe patients need to adopt comprehensive treatment measures such as operation and the like clinically.
Disclosure of Invention
Aiming at the defects of the existing medical treatment, the invention provides an enema formula for treating spleen deficiency and damp-heat syndrome in the active period of chronic ulcerative colitis.
In order to solve the technical problems, the invention adopts the technical scheme that:
an enema formula for treating spleen deficiency and damp-heat syndrome in an active period of chronic ulcerative colitis is prepared from the following raw materials in parts by weight: 5.0-7.0 parts of poria cocos, 5.0-7.0 parts of purslane, 3.5-5.5 parts of herba patriniae, 3.5-5.5 parts of paniculate swallowwort root, 3.5-5.5 parts of paederia scandens, 2.0-4.0 parts of folium callicarpae pedunculatae, 2.0-4.0 parts of Chinese gall, 2.0-4.0 parts of palm charcoal, 2.0-4.0 parts of rhubarb charcoal, 2.0-4.0 parts of sophora japonica charcoal, 2.0-4.0 parts of crinis carbonisatus and 2.0-4.0 parts of dried alum.
Preferably, the enema formula for treating spleen deficiency and damp-heat syndrome in the active period of chronic ulcerative colitis is prepared from the following raw materials in parts by weight: 5.5-6.5 parts of poria cocos, 5.5-6.5 parts of purslane, 4.0-5.0 parts of herba patriniae, 4.0-5.0 parts of paniculate swallowwort root, 4.0-5.0 parts of paederia scandens, 2.5-3.5 parts of folium callicarpae pedunculatae, 2.5-3.5 parts of gallnut, 2.5-3.5 parts of palm charcoal, 2.5-3.5 parts of rhubarb charcoal, 2.5-3.5 parts of sophora japonica charcoal, 2.5-3.5 parts of crinis carbonisatus and 2.5-3.5 parts of dried alum.
Preferably, the enema formula for treating spleen deficiency and damp-heat syndrome in the active period of chronic ulcerative colitis is prepared from the following raw materials in parts by weight: 6.0 parts of poria cocos, 6.0 parts of purslane, 4.5 parts of patrinia, 4.5 parts of cynanchum paniculatum, 4.5 parts of paederia scandens, 3.0 parts of callicarpa bodinieri, 3.0 parts of gallnut, 3.0 parts of palm charcoal, 3.0 parts of rhubarb charcoal, 3.0 parts of sophora flower charcoal, 3.0 parts of crinis carbonisatus and 3.0 parts of dried alum.
Preferably, in the enema formula for treating spleen deficiency and damp-heat syndrome in the active period of chronic ulcerative colitis, the weight parts of the raw materials are 10g per 1 part.
The preparation method of the enema formula for treating spleen deficiency and damp-heat syndrome in the active period of chronic ulcerative colitis comprises the following steps:
weighing raw material components of each medicine according to parts by weight, cleaning, drying and crushing;
secondly, adding the smashed mixed raw materials into a marmite or a stainless steel pan, adding water to submerge the medicine surface, soaking for 60 minutes, heating and boiling for 60 minutes, filtering to obtain decoction, adding water into medicine residues, decocting for 60 minutes again, combining the decoction obtained in the two times, standing, filtering out precipitates, taking 200mL of the medicine liquid, subpackaging the medicine liquid into 250mL of infusion bottles, and sterilizing at 115 ℃ for 40 minutes to obtain the traditional Chinese medicine enema formula for treating chronic ulcerative colitis; or
A YFY13/3A type medicine decocting machine is adopted, 3-6 doses of medicine raw materials are filled into a disposable filter bag, 1000mL of water is mixed with one dose of medicine for soaking for 30 minutes, then the medicine is sealed for decocting for 30 minutes, decoction is filtered out, and the decoction is sealed into 200mL of liquid medicine per bag under the aseptic condition, so that the traditional Chinese medicine enema formula for treating chronic ulcerative colitis is obtained.
The application of the enema formula for treating the spleen deficiency and damp-heat syndrome in the active period of chronic ulcerative colitis is 200mL each time, the enema is kept 2 times a day, and the enema is stopped for 1 day after 14 days of continuous enema.
The formula is as follows: according to the problems of repeated symptoms, poor curative effect and high cost of treatment medicines of the existing chronic ulcerative colitis patients, the traditional Chinese medicine enema formula is developed by years of clinical trials and referring to a large amount of evidence-based medical data, and clinical research and observation show that the traditional Chinese medicine enema formula has better antidiarrheal and hemostatic effects. The enema prescription is selected for the administration route, just as the principle of external treatment, i.e. internal treatment, described in Ji '28729Zhou-Wen' of Ming Dynasty famous medical Wu-Shi. … … the externally-applied medicine, i.e. the internally-applied medicine … … ", is mainly the same in the way of external application and internal application, and the internally-applied medicine can also be absorbed by external enema to act.
And (3) composition analysis: the traditional Chinese medicine enema formula for treating spleen deficiency and damp-heat syndrome in the active period of chronic ulcerative colitis, disclosed by the invention, has the effects of tonifying spleen and excreting dampness, clearing away heat and toxic materials, stopping bleeding and treating dysentery by using purslane as main medicines; herba Patriniae has effects of clearing away heat and toxic materials, resolving carbuncle and relieving pain, radix Cynanchi Paniculati has effects of removing toxic substances and detumescence, dispelling pathogenic wind and relieving pain, herba Paederiae has effects of invigorating stomach and relieving pain, removing toxic substances and treating dysentery, folium Callicarpae Formosanae has effects of astringing and stopping bleeding, clearing heat and removing toxic substances, and the four are adjuvant principal drugs, which are minis; galla chinensis, used as adjuvant drugs, has effects of astringing intestine to stop diarrhea, and astringing to stop bleeding, and is prepared from fortune Windmillpalm charcoal, crinis Carbonisatus charcoal, Sophora flower charcoal, and rhubarb charcoal; dried alum is used as a guiding drug for drying dampness, checking diarrhea and stopping bleeding. The whole formula is combined to play the roles of strengthening spleen and eliminating dampness, clearing heat and detoxicating, and stopping bleeding and treating dysentery.
The invention has the beneficial effects that:
1. the traditional Chinese medicine enema formula disclosed by the invention has a unique curative effect in the treatment of the active period of chronic ulcerative colitis, and through retention enema, on one hand, the medicine can directly act on intestinal mucosa to play the roles of clearing heat and removing toxicity, stopping bleeding and treating dysentery, and on the other hand, the medicine can be absorbed by the intestinal mucosa and can also act on the spleen and stomach, so that the functions of adjusting viscera and strengthening spleen and clearing damp are achieved.
2. The traditional Chinese medicine retention enema can enable the medicine to directly reach the focus, improves the local medicine concentration, avoids the first-pass elimination effect of oral administration, reduces liver metabolism, reduces the stimulation to the stomach, reduces toxic and side effects, and achieves the effects of cleaning the intestinal tract, removing the necrotic tissue, promoting granulation, astringing to stop bleeding, recovering the barrier function of the intestinal mucosa and regulating the intestinal flora. The traditional Chinese medicine enema can directly enter blood after being absorbed by intestinal mucosa, promotes blood circulation, enhances digestive function, has the functions of strengthening spleen and excreting dampness, detoxifying and stopping bleeding, stopping diarrhea and treating dysentery, accelerates the recovery of ulcerative colitis, and overcomes the defect that the curative effect of part of patients is not good because of long-term oral administration of medicines.
3. The traditional Chinese medicine enema formula disclosed by the invention has the effects of tonifying spleen, clearing damp, clearing heat, detoxifying, stopping bleeding and treating dysentery, the clinical effective rate is more than 90%, the medicine sources are sufficient, the processing and the preparation are easy, the application is convenient, no drug resistance or adverse reaction occurs, the clinical medicine effect can be better exerted, and the medicine taking risk of patients with ulcerative colitis is reduced.
4. The traditional Chinese medicine enema formula disclosed by the invention is remarkable in curative effect, simple and convenient to operate, safe and reliable, easy to accept by patients, convenient to popularize clinically and very important in clinical value for treating ulcerative colitis.
Detailed Description
The technical solutions of the present invention are further described in detail with reference to specific examples so that those skilled in the art can better understand the present invention and can implement the present invention, but the examples are not intended to limit the present invention.
Example 1
An enema formula for treating spleen deficiency and damp-heat syndrome in an active period of chronic ulcerative colitis is prepared from the following raw materials in parts by weight: 5.0 parts of tuckahoe, 5.0 parts of purslane, 3.5 parts of herba patriniae, 3.5 parts of paniculate swallowwort root, 3.5 parts of Chinese fevervine, 2.0 parts of callicarpa bodinieri leaf, 2.0 parts of gallnut, 2.0 parts of palm charcoal, 2.0 parts of rhubarb charcoal, 2.0 parts of sophora flower charcoal, 2.0 parts of crinis carbonisatus and 2.0 parts of dried alum.
The preparation method of the enema formula for treating spleen deficiency and damp-heat syndrome in the active period of chronic ulcerative colitis comprises the following steps:
weighing raw material components of each medicine according to the parts by weight, cleaning, drying and crushing;
secondly, adding the smashed mixed raw materials into a marmite or a stainless steel pot, adding water to submerge the medicine surface, soaking for 60 minutes, heating and boiling for 60 minutes, filtering out decoction, adding water into medicine dregs, decocting for 1 hour again, combining the decoction of the two times, standing, filtering out precipitates, taking 200mL of medicine liquid, subpackaging into 250mL of infusion bottles, and sterilizing at 115 ℃ for 40 minutes to obtain the traditional Chinese medicine enema formula for treating chronic ulcerative colitis.
Example 2
An enema formula for treating spleen deficiency and damp-heat syndrome in an active period of chronic ulcerative colitis is prepared from the following raw materials in parts by weight: 5.5 parts of tuckahoe, 5.5 parts of purslane, 4.0 parts of herba patriniae, 4.0 parts of paniculate swallowwort root, 4.0 parts of Chinese fevervine herb, 2.5 parts of callicarpa bodinieri leaf, 2.5 parts of gallnut, 2.5 parts of palm charcoal, 2.5 parts of rhubarb charcoal, 2.5 parts of sophora flower charcoal, 2.5 parts of crinis carbonisatus and 2.5 parts of dried alum.
The preparation method of the enema formula for treating spleen deficiency and damp-heat syndrome in the active period of chronic ulcerative colitis comprises the following steps:
weighing raw material components of each medicine according to the parts by weight, cleaning, drying and crushing;
secondly, adding the smashed mixed raw materials into a marmite or a stainless steel pot, adding water to submerge the medicine surface, soaking for 60 minutes, heating and boiling for 60 minutes, filtering out decoction, adding water into medicine dregs for decocting for 60 minutes again, combining the decoction of the two times, standing, filtering out precipitates, taking 200mL of medicine liquid, subpackaging into 250mL of infusion bottles, and sterilizing at 115 ℃ for 40 minutes to obtain the traditional Chinese medicine enema formula for treating chronic ulcerative colitis.
Example 3
An enema formula for treating spleen deficiency and damp-heat syndrome in an active period of chronic ulcerative colitis is prepared from the following raw materials in parts by weight: 6.0 parts of poria cocos, 6.0 parts of purslane, 4.5 parts of patrinia, 4.5 parts of cynanchum paniculatum, 4.5 parts of paederia scandens, 3.0 parts of callicarpa bodinieri, 3.0 parts of gallnut, 3.0 parts of palm charcoal, 3.0 parts of rhubarb charcoal, 3.0 parts of sophora flower charcoal, 3.0 parts of crinis carbonisatus and 3.0 parts of dried alum.
The preparation method of the enema formula for treating spleen deficiency and damp-heat syndrome in the active period of chronic ulcerative colitis comprises the following steps:
weighing raw material components of each medicine according to the parts by weight, cleaning, drying and crushing;
secondly, adding the smashed mixed raw materials into a marmite or a stainless steel pot, adding water to submerge the medicine surface, soaking for 60 minutes, heating and boiling for 60 minutes, filtering out decoction, adding water into medicine dregs for decocting for 60 minutes again, combining the decoction of the two times, standing, filtering out precipitates, taking 200mL of medicine liquid, subpackaging into 250mL of infusion bottles, and sterilizing at 115 ℃ for 40 minutes to obtain the traditional Chinese medicine enema formula for treating chronic ulcerative colitis.
Example 4
An enema formula for treating spleen deficiency and damp-heat syndrome in an active period of chronic ulcerative colitis is prepared from the following raw materials in parts by weight: 6.5 parts of poria cocos, 6.5 parts of purslane, 5.0 parts of patrinia, 5.0 parts of cynanchum paniculatum, 5.0 parts of paederia scandens, 3.5 parts of callicarpa bodinieri, 3.5 parts of gallnut, 3.5 parts of palm charcoal, 3.5 parts of rheum officinale charcoal, 3.5 parts of sophora flower charcoal, 3.5 parts of crinis carbonisatus and 3.5 parts of dried alum.
The preparation method of the enema formula for treating spleen deficiency and damp-heat syndrome in the active period of chronic ulcerative colitis comprises the following steps:
weighing raw material components of each medicine according to the parts by weight, cleaning, drying and crushing;
secondly, adding the smashed mixed raw materials into a marmite or a stainless steel pot, adding water to submerge the medicine surface, soaking for 60 minutes, heating and boiling for 60 minutes, filtering out decoction, adding water into medicine dregs for decocting for 60 minutes again, combining the decoction of the two times, standing, filtering out precipitates, taking 200mL of medicine liquid, subpackaging into 250mL of infusion bottles, and sterilizing at 115 ℃ for 40 minutes to obtain the traditional Chinese medicine enema formula for treating chronic ulcerative colitis.
Example 5
An enema formula for treating spleen deficiency and damp-heat syndrome in an active period of chronic ulcerative colitis is prepared from the following raw materials in parts by weight: 7.0 parts of poria cocos, 7.0 parts of purslane, 5.5 parts of patrinia, 5.5 parts of cynanchum paniculatum, 5.5 parts of paederia scandens, 4.0 parts of callicarpa bodinieri, 4.0 parts of gallnut, 4.0 parts of palm charcoal, 4.0 parts of rhubarb charcoal, 4.0 parts of sophora flower charcoal, 4.0 parts of crinis carbonisatus and 4.0 parts of dried alum.
The preparation method of the enema formula for treating spleen deficiency and damp-heat syndrome in the active period of chronic ulcerative colitis comprises the following steps:
weighing raw material components of each medicine according to the parts by weight, cleaning, drying and crushing;
and secondly, taking more than 4 doses of the medicinal raw materials, filling the crushed mixed raw materials into a disposable filter bag, putting the disposable filter bag into a YFY13/3A type decocting machine, mixing and soaking the medicinal raw materials for 30 minutes in 1000mL of water, then carrying out closed decoction for 30 minutes, filtering the decoction after the completion, and sealing the decoction into 200mL of liquid medicine per bag under the aseptic condition to obtain the traditional Chinese medicine enema formula for treating the chronic ulcerative colitis.
Clinical efficacy experiment
The clinical effect observation of the traditional Chinese medicine enema formula prepared by the invention is as follows:
1. general data
(1) Inclusion criteria were: the Western medicine diagnosis refers to the consensus opinion on the diagnosis and treatment standard of inflammatory bowel disease in China (2012) formulated by the Cooperation group of the digestive disease society of the Chinese medical society, and routine examination of liver function, kidney function, blood, urine and feces has no obvious abnormality in the last 1 year. The syndrome differentiation of the traditional Chinese medicine accords with the syndrome of ulcerative colitis and spleen deficiency and dampness-heat, and the traditional Chinese medicine diagnosis standard refers to the consensus opinion of traditional Chinese medicine diagnosis and treatment experts of ulcerative colitis (2017) formulated by the spleen and stomach disease division of the Chinese medical society.
(2) Exclusion criteria: patients with severe ulcerative colitis, intestinal occupancy and other serious complications; ② pregnant or lactating women; severe liver and kidney insufficiency, malignant tumor and incapability of tolerating general anesthesia as evaluated by an anesthesiologist; patients with cardiovascular and cerebrovascular diseases; patients with other immune and organ failure diseases are combined; sixthly, the patients with psychosis are combined; seventhly, other serious infectious diseases such as pulmonary tuberculosis and HIV positive patients are combined; and ninthly, people allergic to various medicines participate in other clinical testers within 3 months.
(3) Case selection: the selection meets the inclusion standard and belongs to the diagnosis standard of Western medicine chronic ulcerative colitis, the disease stage is active stage, the disease degree is mild and moderate, 66 patients with spleen deficiency and dampness-heat syndrome are identified in Chinese medicine, and 33 patients are randomly divided into an observation group and a control group. In the observation group 33, 1 male was dropped, and the remaining 32 male were 18 female; age (37.68 + -10.52). In the control group 33, 1 female was dropped, and the remaining 32 cases were 19 male and 12 female; age (38.26 ± 9.75) years.
2. Method of treatment
(1) Control group: conventional treatment in western medicine: mesalazine enteric coated tablet (0.25 g per tablet, manufactured by sunflower pharmaceutical group Jia Mus Luling pharmaceutical Co., Ltd., national Standard H19980148), 1g per time, 4 times daily, is orally administered.
(2) Observation group: on the basis of the treatment of a control group, a traditional Chinese medicine retention enema formula is added, 200mL of the enema is used every time, 2 times are taken every day, 1 time is changed every 4 weeks after the treatment, the enema is retained, and the rest is carried out for 1 day after 14 days of continuous enema. The sausage filling method comprises the following steps: the temperature of the enema liquid is preferably (39 +/-0.5) DEG C, the left lateral position is firstly taken, the buttocks are fully exposed, a treatment towel is paved, the buttocks are lifted by about 10cm, the front end of the anal tube is lubricated, the anal tube is inserted into the rectum by 15cm, and the administration speed of the enema is adjusted according to the tolerance condition of a patient, and is usually 80 drops/min. And (3) posture adjustment: if the rectum, sigmoid colon and left half colon are ulcerated, the left lateral decubitus is taken, and the retention time of the enema is prolonged as much as possible; if the ulcer surface is extensive or affects the whole colon, the left lateral decubitus, the horizontal decubitus and the right lateral decubitus are sequentially taken for 20min, and then the patient is rested in a comfortable position.
(3) The course of treatment is as follows: the treatment period is 1 treatment course for 8 weeks in both groups.
3. Standard of therapeutic effect
(1) Comprehensive therapeutic effect evaluation standard
Clinical cure: the symptom sign disappears, and the abdominal pain, diarrhea, purulent bloody stool completely disappears; the absolute score for the endoscopic sub-score was 0 or 1 for the Mayo score.
The effect is shown: the symptoms are obviously relieved, and the abdominal pain, diarrhea, purulent bloody stool are obviously relieved; the total Mayo score is less than or equal to 2 points and no single subentry score is more than 1 point.
Improvement: the symptoms are relieved, and the bellyache, the diarrhea and the purulent bloody stool relatively disappear; the Mayo score decreased endoscopic sub-score by at least 1 point relative to baseline.
And (4) invalidation: if the above criteria are not met, the disease condition is not improved or worsened.
(2) Evaluation criteria of syndrome therapeutic effect
Refer to the clinical research principles of New Chinese medicine published by the publishing agency of Chinese medical science and technology in 5 months in 2002
Clinical cure: the symptoms and physical signs disappear or basically disappear, and the syndrome score is reduced by more than or equal to 95 percent.
The effect is shown: the symptoms and physical signs are obviously improved, and the syndrome integral is reduced by more than or equal to 70 percent.
The method has the following advantages: the symptoms and physical signs are obviously improved, and the syndrome integral is reduced by more than or equal to 30 percent.
And (4) invalidation: the symptoms and physical signs are not obviously improved or even aggravated, and the syndrome integral is reduced by less than 30 percent.
The calculation formula (nimodipine method) is: [ (before treatment integration-after treatment integration) ÷ before treatment integration ] × 100%
(3) The evaluation of the curative effect of the enteroscopy inflammation refers to the consensus opinion of traditional Chinese medicine diagnosis and treatment experts of ulcerative colitis (2017), and an improved Mayo activity index is adopted.
The clinical effect is as follows: the total Mayo score is reduced by more than or equal to 30 percent or more than or equal to 3 points from the baseline level, and meanwhile, the hematochezia sub-score is reduced by more than or equal to 1 point or the absolute score of the hematochezia sub-score is 0 or 1.
Clinical remission: the total Mayo score is less than or equal to 2 points and no single subentry score is more than 1 point.
Endoscope response: the Mayo score decreased endoscopic sub-score by at least 1 point relative to baseline.
And (3) mucosa healing: the absolute score for the endoscopic sub-score was 0 or 1 for the Mayo score.
4. Statistical method
Data were processed using SPSS19.0 statistical analysis software. The measured data are expressed as (x + -s), and the comparison between groups adopts t test (or corrects t test); the count data are expressed as percentages and the comparisons between groups are by x2Checking; the grade data is tested by rank sum H, and the difference with P less than 0.05 has significance statistics.
5. Results
(1) The two groups of the composition have a combined therapeutic effect, which is shown in Table 1
TABLE 1 comparison of the comprehensive therapeutic effects of the observed group and the control group [ case (%) ]
Note: compared with the curative effect of the control group, the difference has significant statistical significance (P is less than 0.05)
In 32 cases of an observation group, 11 cases are clinically cured, 14 cases are obviously effective, 5 cases are effective, 2 cases are ineffective, and the total effective rate is 93.75%; in 32 cases of the control group, 8 cases are clinically cured, 12 cases are obviously effective, 7 cases are effective, 5 cases are ineffective, and the total effective rate is 84.38%. Through statistical treatment, the curative effect of the treatment group is obviously better than that of the control group (P is less than 0.05).
(2) The two syndromes are compared in terms of efficacy, as shown in Table 2
TABLE 2 comparison of the syndrome therapeutic effects of the observation group and the control group [ case (%) ]
Note: compared with the curative effect of a control group, the difference has significant statistical significance (P is less than 0.05).
In 32 observation groups, 12 cases are clinically cured, 14 cases are obviously effective, 5 cases are effective, 1 case is ineffective, and the total effective rate is 96.88%; in 32 cases of the control group, 9 cases are clinically cured, 12 cases are obviously effective, 7 cases are effective, 4 cases are ineffective, and the total effective rate is 87.50%. Through statistical treatment, the curative effect of the treatment group is obviously better than that of the control group (P is less than 0.05).
(3) Comparison of endoscope response rates before and after two groups of treatments, see Table 3
TABLE 3 comparison of the results of the enteroscopy before and after the two groups of treatments [ case (%) ]
Note: compared with the curative effect of a control group, the difference has significant statistical significance.
(4) Comparison of Mayo score improvement before and after treatment in two groups, see Table 4
TABLE 4 comparison of Mayo score improvement before and after treatment (x + -s)
Note: comparison with this group before treatment:*p is less than 0.01; comparison with control group after treatment:△P<0.05。
6. and (4) adverse reaction observation: no obvious adverse reaction occurred in both groups of patients.
The above description is only a preferred embodiment of the present invention, and not intended to limit the scope of the present invention, and all modifications of equivalent structures and equivalent processes, which are made by the present specification, or directly or indirectly applied to other related technical fields, are included in the scope of the present invention.
Claims (6)
1. An enema formula for treating spleen deficiency and damp-heat syndrome in an active period of chronic ulcerative colitis is characterized by being prepared from the following traditional Chinese medicine raw materials in parts by weight: 5.0-7.0 parts of poria cocos, 5.0-7.0 parts of purslane, 3.5-5.5 parts of herba patriniae, 3.5-5.5 parts of paniculate swallowwort root, 3.5-5.5 parts of paederia scandens, 2.0-4.0 parts of folium callicarpae pedunculatae, 2.0-4.0 parts of Chinese gall, 2.0-4.0 parts of palm charcoal, 2.0-4.0 parts of rhubarb charcoal, 2.0-4.0 parts of sophora japonica charcoal, 2.0-4.0 parts of crinis carbonisatus and 2.0-4.0 parts of dried alum.
2. The enema formula for treating spleen deficiency and damp-heat syndrome in the active period of chronic ulcerative colitis according to claim 1, wherein the traditional Chinese medicine raw materials in parts by weight are as follows: 5.5-6.5 parts of poria cocos, 5.5-6.5 parts of purslane, 4.0-5.0 parts of herba patriniae, 4.0-5.0 parts of paniculate swallowwort root, 4.0-5.0 parts of paederia scandens, 2.5-3.5 parts of folium callicarpae pedunculatae, 2.5-3.5 parts of gallnut, 2.5-3.5 parts of palm charcoal, 2.5-3.5 parts of rhubarb charcoal, 2.5-3.5 parts of sophora japonica charcoal, 2.5-3.5 parts of crinis carbonisatus and 2.5-3.5 parts of dried alum.
3. The enema formula for treating spleen deficiency and damp-heat syndrome in the active period of chronic ulcerative colitis according to claim 1, wherein the traditional Chinese medicine raw materials in parts by weight are as follows: 6.0 parts of poria cocos, 6.0 parts of purslane, 4.5 parts of patrinia, 4.5 parts of cynanchum paniculatum, 4.5 parts of paederia scandens, 3.0 parts of callicarpa bodinieri, 3.0 parts of gallnut, 3.0 parts of palm charcoal, 3.0 parts of rhubarb charcoal, 3.0 parts of sophora flower charcoal, 3.0 parts of crinis carbonisatus and 3.0 parts of dried alum.
4. The enema formula for treating spleen deficiency and damp-heat syndrome during active period of chronic ulcerative colitis according to claims 1-3, wherein the weight portion of the raw materials is 10g per 1 portion.
5. The preparation method of the enema formula for treating spleen deficiency and damp-heat syndrome in the active period of chronic ulcerative colitis according to claim 1, comprising the following steps:
weighing raw material components of each medicine according to parts by weight, cleaning, drying and crushing;
secondly, adding the smashed mixed raw materials into a marmite or a stainless steel pan, adding water to submerge the medicine surface, soaking for 60 minutes, heating and boiling for 60 minutes, filtering to obtain decoction, adding water into medicine residues, decocting for 60 minutes again, combining the decoction obtained in the two times, standing, filtering out precipitates, taking 200mL of the medicine liquid, subpackaging the medicine liquid into 250mL of infusion bottles, and sterilizing at 115 ℃ for 40 minutes to obtain the traditional Chinese medicine enema formula for treating chronic ulcerative colitis; or
A YFY13/3A type medicine decocting machine is adopted, 3-6 doses of medicine raw materials are filled into a disposable filter bag, 1000mL of water is mixed with one dose of medicine for soaking for 30 minutes, then the medicine is sealed for decocting for 30 minutes, decoction is filtered out, and the decoction is sealed into 200mL of liquid medicine per bag under the aseptic condition, so that the traditional Chinese medicine enema formula for treating chronic ulcerative colitis is obtained.
6. The application of the enema formula for treating spleen deficiency and damp-heat syndrome in the active period of chronic ulcerative colitis as claimed in claims 1-5, wherein 200mL of enema is kept twice a day each time, and the enema is stopped for 1 day after 14 days of continuous enema.
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