CN101837096A

CN101837096A - Enema medicament for curing ulcerative colitis

Info

Publication number: CN101837096A
Application number: CN201010191286A
Authority: CN
Inventors: 牛菊萍
Original assignee: Individual
Current assignee: Individual
Priority date: 2010-05-31
Filing date: 2010-05-31
Publication date: 2010-09-22
Anticipated expiration: 2030-05-31
Also published as: CN101837096B

Abstract

The invention relates to an enema medicament for curing ulcerative colitis. A method for preparing the enema medicament comprises the step of: adding water into Chinese pulsatilla root, herba portulacae, baical skullcap root, golden thread, carbonized Chinese angelica, carbonized garden burnet root, carbonized rhubarb, cassia bark, donkey-hide glue, white paeony root, liquoric root, and bletilla, decocting the mixture twice, wherein the amount of adding water each time is 3 to 4 times the weight of the medicinal materials; and decocting the mixture for 2 to 4h, merging decoction, filtering and concentrating filtrate until the weight of the filtrate is 1.5 to 3 times the total weight of the raw material medicaments, sterilizing, packing, and preparing the enema medicament. 200mL of the enema medicament is taken each time, and the enema medicament is taken twice every day. The medicament has the effects of clearing heat and detoxicating, dissipating blood and dispersing swelling, engendering flesh and reliving pain, and reaching focus, is used for curing the ulcerative colitis, stomachache, and purulent and bloody stool, and can alleviate symptoms and promote ulcers to heal. The clinical observation of clinical 50 cases of patients with the ulcerative colitis shows that the enema medicament has the advantages of 96.0 percent of total effective rate, obvious effect and safe curative effect.

Description

A kind of enema medicament for the treatment of ulcerative colitis

Technical field

The invention belongs to technical field of Chinese medicines, relating to a kind of is the medicine of the treatment ulcerative colitis of crude drug with Chinese medicine.

Background technology

Colitis claims nonspecific ulcerative colitis again, and a lot of diseases are slow, and state of an illness weight differs, and its main clinical manifestation is diarrhoea, abdominal distention, and stomachache has to continue or repeated relapsing, discharges bloody purulent stool, mucosanguineous feces or hemafecia, often accompanies tenesmus, difficult defecation.Ulcerative colitis has multiple, outbreak repeatedly easily, and the touching difficulty of the state of an illness is more.

The doctor trained in Western medicine traditional therapy is to use single medicine such as anti-infective, hormone medicine, immunosuppressant, diarrhea etc. to treat, and plays antiinflammatory, pain relieving, antidiarrheal and temporarily alleviates effect with relief of symptoms, can not realize that essence cures.And Western medicine has stimulation to intestinal, and more or less side effect arranged all, takes a kind of medicine for a long time, and gastrointestinal function takes a turn for the better for the moment, recurrence again then, even the state of an illness increases the weight of.Therefore, increasing patient wishes to select Chinese medicine to cure colitis.

Summary of the invention

The purpose of this invention is to provide the Chinese medicine medicine of a kind of obvious results by the enema treatment ulcerative colitis.

Medicine of the present invention is that crude drug prepares by following parts by weight of traditional Chinese medicines:

The Radix Pulsatillae 10～20 MAZHIXIANs 10～20 Radix Scutellariaes 10～20

Rhizoma Coptidis 5～12 Radix Angelicae Sinensis carbon 5～12 charred Radix Sanguisorbae 5～12

Charred Radix Et Rhizoma Rhei 5～12 Cortex Cinnamomis 3～6 Colla Corii Asini 5～12

The Radix Paeoniae Alba 1～2 Radix Glycyrrhizae 15～30 Pseudobulbus Bletillae (Rhizoma Bletillae)s 5～12.

The concrete preparation method of above-mentioned each crude drug being made enema medicament of the present invention is:

Get the Radix Pulsatillae, MAZHIXIAN, Radix Scutellariae, Rhizoma Coptidis, Radix Angelicae Sinensis carbon, charred Radix Sanguisorbae, charred Radix Et Rhizoma Rhei, Cortex Cinnamomi, Colla Corii Asini, the Radix Paeoniae Alba, Radix Glycyrrhizae, the Pseudobulbus Bletillae (Rhizoma Bletillae) by above-mentioned parts by weight, decoct with water 2 times, each amount of water is 3～4 times of medical material weight, decoct 2～4h, collecting decoction filters, and filtrate is condensed into 1.5～3 times of crude drug gross weight, sterilization packaging is made enema medicament.

Usage: each 200mL, every day 2 times, the coloclysis of using of adult.

Theory of Chinese medical science is thought, colitis mostly is damp and hot heap soil or fertilizer over and around the roots knot, deficiency of spleen-YANG and kidneyYANG, QI and blood deficiency, qi depression to blood stasis, drinking and eating irregularly, overworks, Nervous and Mental Factors and bringing out, function of spleen and stomach regulating, spleen invigorating benefit intestinal is not only wanted in treatment, also answer cold and heat lead to benefit, spleen invigorating and in, adjust the dual power of negative and positive principles.In the prescription of the present invention, Radix Pulsatillae bitterness, bloody dysentery stomachache is treated in the pain relieving of energy removing blood stasis; The acid of MAZHIXIAN abnormal smells from the patient is cold nontoxic, the blood that can loose detumescence, and sharp intestinal detoxifcation is controlled dysentery, swelling and pain of anus; Rhizoma Coptidis, Radix Scutellariae heat clearing and damp drying dysentery relieving are joined the Cortex Cinnamomi warming middle-JIAO and are ended cold; Radix Angelicae Sinensis carbon, charred Radix Sanguisorbae, charred Radix Et Rhizoma Rhei clearing away heat and cooling blood, hemostasis is nourished blood; Colla Corii Asini nourishing blood; Irritability is held back in Radix Paeoniae Alba acid, makes its catharsis too, more can the easing the affected liver emergency, for controlling the key medicine of stomachache; Pseudobulbus Bletillae (Rhizoma Bletillae) abnormal smells from the patient is worked hard, and cures mainly the carbuncle malignant boil, the granulation promoting pain relieving.All medicine compatibilities, heat-clearing and toxic substances removing, the blood detumescence of loosing, the granulation promoting pain relieving, through focus is used for the treatment of ulcerative colitis, stomachache, stool containing pus and blood, but mitigation symptoms are impelled ulcer healing.

Medicine of the present invention is by coloclysis approach treatment ulcerative colitis, easy to use, efficiently solving the treatment of traditional ulcerative colitis can only the respite symptom, incurable problem, provide a kind of clinical effectiveness good, can thoroughly treat the medicine of ulcerative colitis.

For further investigating the clinical efficacy and the safety of medicine of the present invention, select 50 routine ulcerative colitis cases that the curative effect of medicine of the present invention is carried out clinical observation.

50 routine MethodsThe cases enrolled all meet chronic non-specific ulcerative colitis diagnosis typing and the treatment standard that All-China Association of Traditional Chinese Medicine's analogy can be formulated in 1987, are divided into two groups at random, and treatment is organized in 25 examples, man's 15 examples, women 10 examples, matched group 25 examples, man's 18 examples, women 7 examples.Two groups of 35 years old mean aves, the course of disease is the shortest 3 months, and is the longest 20 years.Two groups of patients no significant difference on sex, age, the course of disease has comparability.

The treatment group gives medicine coloclysis of the present invention, and each 200mL used 15 days every day 2 times continuously, cooperated oral sulfasalazine 2～4g/ time, 4 times/day.Matched group adds XILEI SAN, big, the DIMI coloclysis of celebrating with the saline of same dose, uses continuously 15 days, cooperates oral sulfasalazine 2～4g/ time, 4 times/day.

Curative effect determinate standard: chronic non-specific ulcerative colitis diagnosis typing and the treatment standard that can formulate in 1987 with All-China Association of Traditional Chinese Medicine's analogy are foundation.Cure in the recent period: clinical symptom disappearance, colonoscope check mucosa is normal, drug withdrawal or only do not have recurrence in 6 months with the maintenance dose observed drug.Effectively: clinical symptoms disappears substantially, and mild inflammation reaction of colonoscope check mucosa and part pseudopolyp form.Invalid: clinical symptoms, endoscopic findings and pathologic finding do not have improvement after treating.

Table 1 liang group case treatment back curative effect relatively

The specific embodiment

Embodiment 1

Each medicine is chosen most impurity, screening dry in the sun, after the oven dry, get Radix Pulsatillae 15Kg, MAZHIXIAN 15Kg, Radix Scutellariae 15Kg, Rhizoma Coptidis 10Kg, Radix Angelicae Sinensis carbon 10Kg, charred Radix Sanguisorbae 10Kg, charred Radix Et Rhizoma Rhei 10Kg, Cortex Cinnamomi 5Kg, Colla Corii Asini 10Kg, Radix Paeoniae Alba 2Kg, Radix Glycyrrhizae 20Kg, Pseudobulbus Bletillae (Rhizoma Bletillae) 10Kg, decoct with water 2 times, add water 500Kg at every turn, decoct 2h, collecting decoction filters, and filtrate is condensed into 250Kg, be packaged into the pouch of 200mL, enema medicament is made in sterilization.

Embodiment 2

Get and choose most impurity, screening dry in the sun, Radix Pulsatillae 20Kg after the oven dry, MAZHIXIAN 20Kg, Radix Scutellariae 10Kg, Rhizoma Coptidis 8Kg, Radix Angelicae Sinensis carbon 12Kg, charred Radix Sanguisorbae 12Kg, charred Radix Et Rhizoma Rhei 12Kg, Cortex Cinnamomi 3Kg, Colla Corii Asini 12Kg, Radix Paeoniae Alba 1Kg, Radix Glycyrrhizae 15Kg, Pseudobulbus Bletillae (Rhizoma Bletillae) 6Kg, decoct with water 2 times, add water 500Kg at every turn, decoct 3h, collecting decoction, filter, filtrate is condensed into 250Kg, is packaged into the pouch of 200mL, enema medicament is made in sterilization.

Embodiment 3

Get and choose most impurity, screening dry in the sun, Radix Pulsatillae 12Kg, MAZHIXIAN 12Kg, Radix Scutellariae 20Kg, Rhizoma Coptidis 12Kg, Radix Angelicae Sinensis carbon 6Kg, charred Radix Sanguisorbae 6Kg, charred Radix Et Rhizoma Rhei 6Kg, Cortex Cinnamomi 6Kg, Colla Corii Asini 5Kg, Radix Paeoniae Alba 2Kg, Radix Glycyrrhizae 30Kg, the Pseudobulbus Bletillae (Rhizoma Bletillae) 12Kg of oven dry, decoct with water 2 times, add water 500Kg at every turn, decoct 4h, collecting decoction, filter, filtrate is condensed into 250Kg, is packaged into the pouch of 200mL, enema medicament is made in sterilization.

Claims

1. enema medicament for the treatment of ulcerative colitis is that crude drug prepares by following parts by weight of traditional Chinese medicines:

The Radix Pulsatillae 10～20 MAZHIXIANs 10～20 Radix Scutellariaes 10～20

2. the preparation method of the enema medicament of the described treatment ulcerative colitis of claim 1, be to get the Radix Pulsatillae, MAZHIXIAN, Radix Scutellariae, Rhizoma Coptidis, Radix Angelicae Sinensis carbon, charred Radix Sanguisorbae, charred Radix Et Rhizoma Rhei, Cortex Cinnamomi, Colla Corii Asini, the Radix Paeoniae Alba, Radix Glycyrrhizae, the Pseudobulbus Bletillae (Rhizoma Bletillae) by described parts by weight, decoct with water 2 times, each amount of water is 3～4 times of medical material weight, decocts 2～4h, collecting decoction, filter, filtrate is condensed into 1.5～3 times of crude drug gross weight, and sterilization packaging is made enema medicament.