CN102631435A - Medicament for treating rheumatoid arthritis - Google Patents

Abstract

The invention relates to the field of Chinese herbal medicaments and in particular relates to a medicament for treating rheumatoid arthritis by using Chinese medicaments as bulk pharmaceutical chemicals. The medicament consists of raw bighead atractylodes rhizome, poria, notopterygium root, radix angelicae pubescentis, asarum, ephedra, white peony root, white mustard seed, eucommia bark, pawpaw, peach kernel, safflower, long-noded pit viper and pangolin. The preparation method comprises the following steps: uniformly mixing the bulk pharmaceutical chemicals at a weight ratio; crushing the mixture into powder of 100-120 meshes; sterilizing and disinfecting according to a conventional method; and preparing water-bindered pills by use of a binder. The medicament has the efficacies of dispelling wind and removing obstruction in the meridians, activating blood, warming channel and expelling cold and nourishing bones and tonifying yang, has a remarkable curative effect in treating rheumatoid arthritis. The medicament with the efficacies of dispelling wind and removing obstruction in the meridians, activating blood, warming channel and expelling cold and nourishing bones and tonifying yang has a remarkable curative effect in treating rheumatoid arthritis.

Description

A kind of medicine of treating rheumatoid arthritis

Technical field

The present invention relates to field of Chinese herbal, especially relating to a kind of is the medicine of the treatment rheumatoid arthritis of crude drug preparation with Chinese medicine.

Background technology

Rheumatic arthritis is a kind of common acute or chronic ICT.Can show effect repeatedly and involve heart.Clinical miserable with joint and muscle the. fugitive, heavily work, pain is characteristic.Belong to allergic disease.Be one of main performance of rheumatic fever, how with febris acuta and arthralgia onset.Onset is early stage how similar with anemofrigid cold, is difficult for being paid attention to by people, mainly shows as waist and lower limb and sends out cold, aversion to wind, pain; The chance cold rnning is acute, and activity is stretched pain in the wrong not freely; Like untimely treatment; How to the later stage joint deformity, pain unbearably and cause the disease of heart kidney is in the misery patient for a long time.

Anti-inflammation analgesic, hormone medicine are used in the treatment of rheumatic arthritis more, but can not be effected a radical cure, and take said medicine for a long time, side effect is big at present.

Summary of the invention

The purpose of this invention is to provide a kind of is the medicine of the treatment rheumatic arthritis of crude drug preparation with Chinese medicine, this medicine with dispelling wind and removing obstruction in the collateral, invigorate blood circulation, dispelling cold by warming the meridian, the tonifying YANG of benefit bone be the principle treatment, therapeutic effect is good, expense is low.

Medicine of the present invention is that crude drug prepares by following parts by weight of traditional Chinese medicines:

Rhizoma Atractylodis Macrocephalae 12-16 Poria 12-15

Rhizoma Et Radix Notopterygii 9-12 Radix Angelicae Pubescentis 15-20

Herba Asari 6-9 Herba Ephedrae 6-10

Radix Paeoniae Alba 15-20 Semen Sinapis Albae 12-15

Cortex Eucommiae 12-15 Fructus Chaenomelis 10-15

Semen Persicae 9-12 Flos Carthami 9-12

Agkistrodon 30-50 Squama Manis 8-12.

The medicine of above-mentioned each component can be processed said peroral dosage form on any pharmaceuticss such as tablet, pill, powder, capsule, and the preferred dosage form of the present invention is a water pill.

The concrete method for preparing of medicine water pill of the present invention agent is: said medicine by said parts by weight mix homogeneously, is ground into 100～120 purpose medicated powder, and sterilization uses binding agent to make the water pill product by conventional method.

In the prescription of the present invention, Rhizoma Atractylodis Macrocephalae invigorating the spleen and benefiting QI, dampness diuretic; Poria has eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, the effect of mind tranquilizing and the heart calming; The Rhizoma Et Radix Notopterygii exterior cold of loosing, wind-damp dispelling, sharp joint, pain relieving; The Radix Angelicae Pubescentis expelling wind and dampness, dispersing cold for relieving pain; The Herba Asari cold expelling that induces sweat, wind-expelling pain-stopping, warming the lung to resolve fluid-retention, sensible; Herba Ephedrae diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema; Radix Paeoniae Alba nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing is received antiperspirant; Semen Sinapis Albae warming the lung eliminating phlegm promoting the circulation of QI, the resolving mass and removing the obstruction of the collateral pain relieving; Cortex Eucommiae blood pressure lowering, invigorating the liver and kidney, bone and muscle strengthening; Can also relieve summer heat after Fructus Chaenomelis is aid digestion quench one's thirst, nourishing the lung to arrest cough; The Semen Persicae blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, relieving cough and asthma; The Flos Carthami latus rectum of invigorating blood circulation, eliminating stasis to stop pain; Agkistrodon is dispeled the wind, collateral dredging; Squama Manis is used for blood circulation promoting and dispersing pathogen accumulation, the stimulating milk secretion of stimulating the menstrual flow, and eliminating carbuncle is burst hard.All medicines share, and can play dispelling wind and removing obstruction in the collateral, invigorate blood circulation, the effect of dispelling cold by warming the meridian, the tonifying YANG of benefit bone, and are evident in efficacy to treatment rheumatic arthritis.

For further investigating the clinical efficacy of Drug therapy rheumatic arthritis of the present invention, select 63 routine rheumatic arthritis patients to carry out clinical observation on the therapeutic effect.

Be divided into treatment group and matched group to 63 routine patients, 30 people are organized in treatment, matched group 33 people.

All case is all according to the diagnosis basis in " new Chinese medicine clinical research guideline (first volume) ":

1. clinical manifestation: the streptococcal infection medical history is arranged more; Acute stage, can have multiple and the the. fugitive joint aches, mostly occurs in big joint, can be with redness pain or tuberosity or erythema; Chronic phase, can only be felt joint aches.

2. laboratory examination: anti-" O " is more than 1:500; Or erythrocyte sedimentation rate speeds; Or antistreptokinase surpasses more than 80 units; Or antihyaluronidase is more than 128 units; Or C reflection protein positive.

3. X-ray film does not have the sclerotin damage.

Be diagnosed as rheumatic arthritis.

Therapeutic Method

Matched group adopt to use Western medicine ibuprofen commonly used, and adopted name is an ibuprofen modified release capsule, production firm: Sino-America Tianjin Shike Pharmaceutical Co., Ltd., every day 1 time, one time 2;

The treatment group adopts water pill drug form of the present invention, every day 2 times, each 10 grams.

After the treatment, to treatment group and the inspection of the matched group patient chamber of experimentizing, the result is following:

The variation of each parameter before and after the rheumatic arthritis patient treatment

Criterion of therapeutical effect

Criterion of therapeutical effect with reference to " new Chinese medicine clinical research guideline (first volume) ".Cure: the arthralgia of getting involved after the treatment disappears, and function of joint is improved or recovered normal, and it is normal that erythrocyte sedimentation rate, rheumatoid factor have been recovered; Produce effects: the arthralgia of getting involved is clearly better or disappears, and erythrocyte sedimentation rate, rheumatoid factor titre reduce, or has recovered normal, but arthroncus does not disappear as yet; Effectively: the arthralgia of getting involved after the treatment or swell and ache and take a favorable turn; Invalid: with compare each side and do not have progress before the treatment.

Two groups of case treatment back curative effect comparative results are seen table 1.

Table 1 liang group case treatment back curative effect relatively

Group	The example number	Cure n (%)	Effective n (%)	Invalid n (%)	Total effective rate n (%)
						Matched group	33	11（33.3）	14（42.5）	?8（24.2）	25（75.8）
The treatment group	30	17（56.7）	9（30）	4（13.3）	26（86.7）

Clinical test results proves that drug effect of the present invention obviously is superior to matched group, does not see any untoward reaction.

The specific embodiment

Embodiment 1

Get Rhizoma Atractylodis Macrocephalae 16kg, Poria 15 kg, Rhizoma Et Radix Notopterygii 12 kg, Radix Angelicae Pubescentis 20 kg, Herba Asari 9 kg; Herba Ephedrae 10 kg, the Radix Paeoniae Alba 20 kg, Semen Sinapis Albae 15 kg, the Cortex Eucommiae 15 kg; Fructus Chaenomelis 15 kg, Semen Persicae 12 kg, Flos Carthami 12 kg, Agkistrodon 50 kg; Squama Manis 12 kg by said weight mix homogeneously, are ground into 100～120 purpose medicated powder with said medicine, and sterilization uses binding agent to make the water pill product by conventional method.

Embodiment 2

Get Rhizoma Atractylodis Macrocephalae 12kg, Poria 12kg, Rhizoma Et Radix Notopterygii 9kg, Radix Angelicae Pubescentis 15kg, Herba Asari 6kg; Herba Ephedrae 6kg, Radix Paeoniae Alba 15kg, Semen Sinapis Albae 12 kg, Cortex Eucommiae 12kg; Fructus Chaenomelis 10 kg, Semen Persicae 9kg, Flos Carthami 9kg, Agkistrodon 30kg; Squama Manis 8kg by said weight mix homogeneously, is ground into 100～120 purpose medicated powder with said medicine, and sterilization uses binding agent to make the water pill product by conventional method.

Claims (2)

1. medicine of treating rheumatoid arthritis is that crude drug prepares by following parts by weight of traditional Chinese medicines:

Rhizoma Atractylodis Macrocephalae 12-16 Poria 12-15

Rhizoma Et Radix Notopterygii 9-12 Radix Angelicae Pubescentis 15-20

Herba Asari 6-9 Herba Ephedrae 6-10

Radix Paeoniae Alba 15-20 Semen Sinapis Albae 12-15

Cortex Eucommiae 12-15 Fructus Chaenomelis 10-15

Semen Persicae 9-12 Flos Carthami 9-12

Agkistrodon 30-50 Squama Manis 8-12.

2. the medicine of treatment rheumatoid arthritis according to claim 1 is characterized in that described medicine is processed water pill.