CN105395975A

CN105395975A - Enema traditional Chinese medicine composition treating ulcerative colitis and preparation method thereof

Info

Publication number: CN105395975A
Application number: CN201510972549.1A
Authority: CN
Inventors: 方晓华; 陈莉丽; 杨振斌
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-12-23
Filing date: 2015-12-23
Publication date: 2016-03-16

Abstract

The invention discloses an enema traditional Chinese medicine composition treating ulcerative colitis. The composition is prepared from, by weight, 45-55 g of sanguisorba officinalis, 45-55 g of purslane, 45-55 g of agrimonia pilosa ledeb, 45-55 g of Chinese pulsatilla roots, 45-55 g of ash bark, 45-55 g of cortex phellodendri, 5-15 g of bletilla striata, 45-55 g of coix, 40-50 g of acorus calamus, 40-50 g of rhizoma atractylodis, 40-50 g of lalang grass rhizome and 1-3 g of alums. The traditional Chinese medicine materials are soaked in 500 ml of clean water for 40 min, then is decocted for 10 min with strong fire, decocted for 30 min with slow fire and concentrated to 100 ml, and the decocted medicine liquid is preserved for enema. The composition is used once a day. The prepared medicine can directly act on affected portions and has the effects of clearing away heat and toxin, cooling blood and stopping bleeding and healing sore and promoting granulation. The enema composition is good in effect and low in raw material cost; during preparation of the enema composition, operation is easy and can be easily mastered control by patients.

Description

A kind of coloclysis Chinese medicine composition for the treatment of ulcerative colitis and preparation method thereof

Technical field

The present invention relates to Chinese medicine composition, particularly relate to a kind of coloclysis Chinese medicine composition (also known as elm Herba Amaranthi tricoloris side) can treating ulcerative colitis.

Background technology

Ulcerative colitis is a kind of chronic nonspecific intestinal tract disease being pathological characteristic with rectum, colitis and ulcer, with diarrhoea, mucus bloody purulent stool, stomachache, tenesmus for cardinal symptom, and in recent years the sickness rate of this disease in ascendant trend year by year, clinical treatment difficulty is large, course of disease delay, easily recurrent exerbation, still lack specificity intervening measure, belong in the traditional Chinese medical science " have loose bowels ", " chronic dysentery ", " chronic dysentery with frequent relapse ", the category such as " hemorrhoidal hamorrhage " or " dysentery ".Current is all based on doctor trained in Western medicine to this sick common Therapeutic Method, the medicine of clinical treatment is normally based on 5-aminosalicylic acid and immunosuppressant, but the side effect of life-time service western medicine is general larger, effect is also undesirable, and easily recur after drug withdrawal, cure difficulty large, thus have a strong impact on the quality of life of patient, the diseased region of the patients of ulcerative colitis of 95% is about had to be all be positioned at rectum and colon hypomere in current clinical trouble example, therefore for suffering from the treatment clinical course of patients of ulcerative colitis, medicine can be able to be made to go directly disease institute by the mode of coloclysis administration, diseased region drug level can be improved, gastrointestinal tract can be prevented, liver is to the destruction of medicine, and fundamentally can cure ulcerative colitis, improve the quality of life of patients of ulcerative colitis, just become the focal point of current clinical worker treatment ulcerative colitis, therefore in clinical treatment, a kind of side effect how can be provided little, effective, and can just seem most important at the rapid-action medicine in local.

Summary of the invention

The present invention is directed to the deficiencies in the prior art, provide a kind of coloclysis Chinese medicine composition can treating ulcerative colitis, effectively can solve the medication problem for the treatment of ulcerative colitis.

Technical scheme of the present invention is: a kind of coloclysis Chinese medicine composition for the treatment of ulcerative colitis, and the said composition weight preparing material used is: Radix Sanguisorbae 45-55 gram, Herba portulacae 45-55 gram, Herba Agrimoniae 45-55 gram, Radix Pulsatillae 45-55 gram, Cortex Fraxini 45-55 gram, Cortex Phellodendri 45-55 gram, Pseudobulbus Bletillae (Rhizoma Bletillae) 5-15 gram, Semen Coicis 45-55 gram, Rhizoma Acori Graminei 40-50 gram, Rhizoma Atractylodis 40-50 gram, Rhizoma Imperatae 40-50 gram, Alumen 1-3 gram.

The said composition weight preparing material used is: Radix Sanguisorbae 48-53 gram, Herba portulacae 48-53 gram, Herba Agrimoniae 48-53 gram, Radix Pulsatillae 48-53 gram, Cortex Fraxini 48-53 gram, Cortex Phellodendri 48-53 gram, Pseudobulbus Bletillae (Rhizoma Bletillae) 8-13 gram, Semen Coicis 48-53 gram, Rhizoma Acori Graminei 43-48 gram, Rhizoma Atractylodis 43-48 gram, Rhizoma Imperatae 43-48 gram, Alumen 1.5-2.5 gram.

The said composition weight preparing material used is: Radix Sanguisorbae 50 grams, Herba portulacae 50 grams, Herba Agrimoniae 50 grams, the Radix Pulsatillae 50 grams, Cortex Fraxini 50 grams, Cortex Phellodendri 50 grams, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10 grams, Semen Coicis 50 grams, Rhizoma Acori Graminei 50 grams, Rhizoma Atractylodis 50 grams, Rhizoma Imperatae 40 grams, 1 gram, Alumen.

The said composition weight preparing material used is: Radix Sanguisorbae 50 grams, Herba portulacae 50 grams, Herba Agrimoniae 50 grams, the Radix Pulsatillae 50 grams, Cortex Fraxini 50 grams, Cortex Phellodendri 50 grams, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10 grams, Semen Coicis 50 grams, Rhizoma Acori Graminei 40 grams, Rhizoma Atractylodis 40 grams, Rhizoma Imperatae 50 grams, 3 grams, Alumen.

The pharmacology of above-mentioned several drugs is:

Radix Sanguisorbae: meridian distribution of property and flavor: bitter, sour, is slightly cold; Return liver, stomach, large intestine channel.

Function cures mainly: cooling blood for hemostasis, heat-clearing and toxic substances removing, detumescence sore.

Herba portulacae: meridian distribution of property and flavor: cold, sour; Return liver, large intestine channel.

Function cures mainly: cooling blood for hemostasis, heat-clearing and toxic substances removing, dysentery relieving.

Herba Agrimoniae: meridian distribution of property and flavor: bitter, puckery, flat; GUIXIN, Liver Channel.

Function cures mainly: astringing to arrest bleeding, tonify deficiency, removing food stagnancy, dysentery relieving, parasite killing.

The Radix Pulsatillae: meridian distribution of property and flavor: bitter, cold; Return stomach, large intestine channel.

Function cures mainly: heat-clearing and toxic substances removing, and removing heat from blood controls dysentery.

Cortex Fraxini: meridian distribution of property and flavor: bitter, puckery, cold; Return liver, gallbladder, large intestine channel.

Function cures mainly: heat clearing and damp drying, astringent therapy dysentery relieving, liver heat removing and eyesight improving.

Cortex Phellodendri: meridian distribution of property and flavor: bitter, cold; Return kidney, urinary bladder channel.

Function cures mainly: heat clearing and damp drying, and pathogenic fire purging removes steams, detoxification sore treatment.

The Pseudobulbus Bletillae (Rhizoma Bletillae): meridian distribution of property and flavor: bitter in the mouth, sweet, puckery, cold in nature; Return lung, stomach, Liver Channel.

Function cures mainly: astringing to arrest bleeding, detumescence and promoting granulation.

Semen Coicis: meridian distribution of property and flavor: cool in nature is sweet in the mouth, light; Return spleen, stomach, lung meridian.

Function cures mainly: promoting diuresis to eliminate damp pathogen, eliminating impediment, clearing away heat and discharging pus, invigorating the spleen to arrest diarrhea.

Above-mentioned various medicine has good curative effect to the ulcerative colitis trouble example for the treatment of with stomachache, diarrhoea and bloody purulent stool.

Rhizoma Acori Graminei: meridian distribution of property and flavor: warm in nature, bitter in the mouth, pungent; GUIXIN, stomach two warp.

Function cures mainly: ward off and dirtyly to have one's ideas straightened out, a surname's gas, removing toxic substances, parasite killing.

Rhizoma Atractylodis: meridian distribution of property and flavor: warm in nature, bitter in the mouth, pungent; Return spleen, stomach two warp.

Function cures mainly: drying damp and strengthening spleen, and gastral cavity painful abdominal mass abdominal distention, inappetence, has loose bowels, dysentery.

The use of above-mentioned two kinds of medicines is suffered from example to treatment with stomachache, diarrhoea and white mucus ulcerative colitis just and is had good curative effect.

Rhizoma Imperatae: meridian distribution of property and flavor: cold in nature, sweet in the mouth; Return lung, stomach, urinary bladder channel.

Function cures mainly: cooling blood for hemostasis.

Alumen: meridian distribution of property and flavor: cold in nature, sour-puckery flavor; There is stronger astriction.

Function cures mainly: removing toxic substances parasite killing, hemostasis antidiarrheal.

The use of above-mentioned two kinds of medicines is suffered from example to treatment with a large amount of blood ulcerative colitis just and is had good curative effect.

The preparation of the present composition is: use clear water 500mL, after above-mentioned raw material of Chinese medicine is soaked 40 clocks, decocts 10 minutes with high heat, then with 20 minutes at a simmer, densely decocts to 100mL, then with fried medicinal liquid retention enema, and every day 1 time; Described above-mentioned raw materials is fried into coloclysis medicinal liquid through overrich, by rectum and the colon hypomere position of anum administration patients of ulcerative colitis.

Beneficial effect of the present invention: raw material of the present invention is Chinese herbal medicine, there is effect of heat-clearing and toxic substances removing, cooling blood for hemostasis, heat clearing and damp drying, astringent therapy dysentery relieving, eliminating stagnated food and killing intestinal worms and expelling pus and promoting granulation, traditional Chinese medicine composition for treating of the present invention is effective, cost of material is low, easy to use, safety, effectively can treat ulcerative colitis, and obviously can improve the misery of patients of ulcerative colitis.

Detailed description of the invention

Embodiment one

Take the raw material of lower routine weight: Radix Sanguisorbae 45-55 gram, Herba portulacae 45-55 gram, Herba Agrimoniae 45-55 gram, Radix Pulsatillae 45-55 gram, Cortex Fraxini 45-55 gram, Cortex Phellodendri 45-55 gram, Pseudobulbus Bletillae (Rhizoma Bletillae) 5-15 gram, Semen Coicis 45-55 gram, Rhizoma Acori Graminei 40-50 gram, Rhizoma Atractylodis 40-50 gram, Rhizoma Imperatae 40-50 gram, Alumen 1-3 gram; Use clear water 500mL, after above-mentioned raw material of Chinese medicine is soaked 40 clocks, decoct 10 minutes with high heat, then with 30 minutes at a simmer, densely decoct to 100mL, then with fried medicinal liquid retention enema, every day 1 time.

Embodiment two

Take the raw material of lower routine weight: Radix Sanguisorbae 48-53 gram, Herba portulacae 48-53 gram, Herba Agrimoniae 48-53 gram, Radix Pulsatillae 48-53 gram, Cortex Fraxini 48-53 gram, Cortex Phellodendri 48-53 gram, Pseudobulbus Bletillae (Rhizoma Bletillae) 8-13 gram, Semen Coicis 48-53 gram, Rhizoma Acori Graminei 43-48 gram, Rhizoma Atractylodis 43-48 gram, Rhizoma Imperatae 43-48 gram, Alumen 1.5-2.5 gram; Use clear water 500mL, after above-mentioned raw material of Chinese medicine is soaked 40 clocks, decoct 10 minutes with high heat, then with 30 minutes at a simmer, densely decoct to 100mL, then with fried medicinal liquid retention enema, every day 1 time.

Embodiment three

Take the raw material of lower routine weight: Radix Sanguisorbae 50 grams, Herba portulacae 50 grams, Herba Agrimoniae 50 grams, the Radix Pulsatillae 50 grams, Cortex Fraxini 50 grams, Cortex Phellodendri 50 grams, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10 grams, Semen Coicis 50 grams, Rhizoma Acori Graminei 50 grams, Rhizoma Atractylodis 50 grams, Rhizoma Imperatae 40 grams, 1 gram, Alumen, uses clear water 500mL; After above-mentioned raw material of Chinese medicine is soaked 40 clocks, decoct 10 minutes with high heat, then with 30 minutes at a simmer, densely decoct to 100mL, then with fried medicinal liquid retention enema, every day 1 time.

Embodiment four

Take the raw material of lower routine weight: Radix Sanguisorbae 50 grams, Herba portulacae 50 grams, Herba Agrimoniae 50 grams, the Radix Pulsatillae 50 grams, Cortex Fraxini 50 grams, Cortex Phellodendri 50 grams, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10 grams, Semen Coicis 50 grams, Rhizoma Acori Graminei 40 grams, Rhizoma Atractylodis 40 grams, Rhizoma Imperatae 50 grams, 3 grams, Alumen; Use clear water 500mL, after above-mentioned raw material of Chinese medicine is soaked 40 clocks, decoct 10 minutes with high heat, then with 30 minutes at a simmer, densely decoct to 100mL, then with fried medicinal liquid retention enema; Every day 1 time.

Radix Sanguisorbae described in the present invention, Herba portulacae, Herba Agrimoniae, the Radix Pulsatillae, Cortex Fraxini, Cortex Phellodendri, the Pseudobulbus Bletillae (Rhizoma Bletillae), Semen Coicis, Rhizoma Acori Graminei, Rhizoma Atractylodis, Rhizoma Imperatae and Alumen are all known technologies.

Showing through clinical trial, use safety of the present invention, good effect, is the active drug for the treatment of ulcerative colitis, and is proved by clinical data, pertinent clinical data of the present invention:

1, clinical data

1.1 physical data

60 examples are in January, 2011 in December ,-2013 outpatient service of the spleen-stomach disease section of attached Yangzhou institute of traditional Chinese medicine of Nanjing University of Traditional Chinese Medicine and the patient diagnosed that is in hospital, and it are divided into elm Herba Amaranthi tricoloris side group and matched group at random: sulfasalazine (SASP) bolt group; The concrete clinical data of two groups is respectively in table 1.

The clinical data of table 1 liang group patient

Group

Patient numbers

Men and women

Age (year)

Just control

Control again

The course of disease (year)

Elm Herba Amaranthi tricoloris side group

30

21 9

38.6±9.6

13

17

5.8±1.55

Matched group

30

20 10

39.8±8.7

15

5.6±1.72

Under the age of two groups of patients, course of disease time, the front symptom for the treatment of and colonoscope, the data such as situation, coincident with severity degree of condition is through statistical procedures, and no significant difference (P>0.05), has comparability.

1.2 diagnostic criteria

1.2.1 Western medicine diagnose standard: " the ulcerative colitis combination of Chinese and Western medicine diagnosis and treatment common recognition " that meet digestive system disease Professional Committee of CAIM (Chinese Association Of Integrative Medicine) formulation in 2010 ⁽¹⁾diagnostic criteria.

1.2.2 tcm diagnosis standard: according to " new Chinese medicine guideline of clinical investigations " ⁽²⁾" ulcerative colitis combination of Chinese and Western medicine diagnosis and treatment common recognition " is formulated.

1.3 inclusive criterias: (1) meet ulcerative colitis diagnostic criteria and: a, diseased region are left hemicolon; B, Clinical types are first hair style, chronic relapsing; C, clinical severity are slight, moderate; D, the state of an illness are the patient of active stage by stages.(2) Chinese medical discrimination belongs to syndrome of dampness-heat in large intestine, simultaneous occurrence of cold and heat syndromes, syndrome of stagnation of liver qi and spleen deficiency, insufficiency of the spleenly wet accumulates card.(3) age is between 18-65 year, male or female.(4) informed consent, volunteers tested.

1.4 exclusion standards: the specific infectivity colitis such as (1) bacillary dysentery, amebic dysentery, schistosomicide, tuberculosis of intestine and granulomatous colitis, radiation colitis person.(2) menstrual phase women and pregnant or women breast-feeding their children.(3) other medical history persons are associated with as severe primary diseases such as cardiovascular, cerebrovascular, liver, kidney and hemopoietic systems, psychotic's (comprising allergies).(4) serious complications is had.(5) not by regulation medication, or aggravation, other treatment measure must be taked, cannot curative effect be judged, or the not congruent judgement person that affects the treatment of data.

2, Therapeutic Method

Treatment group elm Herba Amaranthi tricoloris side group drop rectum with drug, prescription is Radix Sangusorbae 50 grams, Herba Portulacae 50 grams, the Radix Pulsatillae 50 grams, Herba Agrimoniae 50 grams, Cortex Phellodendri 50 grams, Semen Coicis 50 grams, Cortex Fraxini 50 grams, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10 grams, Rhizoma Acori Graminei 50 grams, Rhizoma Atractylodis 50 grams, Rhizoma Imperatae 50 grams, 3 grams, Alumen; Use clear water 500mL, after above-mentioned raw material of Chinese medicine is soaked 40 clocks, decoct 10 minutes with high heat, again with 30 minutes at a simmer, densely decoct to 100mL, above-mentioned raw materials is fried into coloclysis medicinal liquid through overrich, by rectum and the colon hypomere position of anum administration patients of ulcerative colitis, every day 1 time.Matched group mixes with SASP1.0g+0.9% normal saline solution 100mL and shakes up, and adds XILEI SAN 1.0g, and two groups of enema are all heated to 37 DEG C-39 DEG C, retention enema before sleeping evening.Two groups of patient's coloclysis every day once, a course for the treatment of four Mondays, after 1 course for the treatment of, the next day drop rectum with drug once, altogether surrounding.Post-evaluation curative effect.

Tcm syndrome before and after 2.1 observation index (1) treatment and clinical efficacy; (2) sub-colonoscope mucosa picture and pathological study; (3) serum IL-10, IL-6 assay.

3, therapeutic evaluation

3.1 tcm syndrome curative effects

With reference to " new Chinese medicine guideline of clinical investigations " in 2002: (1) clinical recovery: tcm clinical practice symptom, sign disappear or substantially disappear, disease integration reduces >=95%; (2) effective: tcm clinical practice symptom, sign are obviously improved, disease integration reduces >=70%; (3) effective: tcm clinical practice symptom, sign all take a favorable turn, disease integration reduces >=30%; (4) invalid: tcm clinical practice symptom, sign are all not improved, even increase the weight of, disease integration reduces less than 30%; Each primary symptom by without, light, in, heavy degree, remember 0 respectively, 2,4,6 points; Computing formula: disease curative effect=[before (treat front integration one and treat rear integration)/treatment integration] * 100.

3.2 doctor trained in Western medicine curative effects

With reference to " ulcerative colitis combination of Chinese and Western medicine diagnosis and treatment common recognition ": complete incidence graph: clinical symptom disappearance, intestinal mirror check non-cancer lesion disappears or cardinal symptom and the total score value reduction >=95% of intestinal mucosa pathological changes activity index substantially; Effective: clinical cardinal symptom is obviously alleviated, intestinal mirror check non-cancer lesion obviously alleviates or cardinal symptom and the total score value of intestinal mucosa pathological changes activity index reduce by 70%; Effective: clinical cardinal symptom is alleviated to some extent, intestinal mirror check non-cancer lesion alleviates to some extent or cardinal symptom and the total score value of intestinal mucosa pathological changes activity index reduce >=30%; Invalid: after treatment, clinical symptoms, scope and pathological examination results are all without improving or increasing the weight of, or cardinal symptom and intestinal mucosa pathological changes activity index total score value reduction <30%; Efficacy assessment standard is according to nimodipine method computing formula: therapeutic index=[(treat front pathological changes activity index integration one and treat rear pathological changes activity index integration) ÷ treats front pathological changes activity index integration] × 100%.

The therapeutic evaluation of 3.3 cardinal symptoms

Curative effect is evaluated: (1) clinic control: after treatment terminates, transference cure with reference to " new Chinese medicine guideline of clinical investigations ".(2) effective: after treatment terminates, symptom integral reduces 2 grades.(3) effective: after treatment terminates, symptom integral reduces l level.(4) invalid: not reach above-mentioned standard person.

3.4SutherlandDAI integration

The difference of integration before and after treatment: (1) <2 is divided into remission; (2) 3 ~ 5 are divided into gentle activity; (3) 6 ~ 10 are divided into moderately active; (4) 11 ~ 12 are divided into severe activity, and calculate remission rate.

3.5 intestinal mirror mucosa performance change situations

Normal mucosa image meter 0 point; Slight pathological changes (the fuzzy mucosa of vascular lake congested but without hemorrhage) meter 3 points; Moderate pathological changes (mucosa is granular change) meter 6 points; Severe pathological changes (mucosa ulcer hematostaxis) counts 9 points.

3.6 colon's pathological change situations

Mucosa lamina propria without neutrophilic infiltration, 0 point: lamina propria has a small amount of neutrophilic leukocyte (<10/HP) to infiltrate, and involves a small amount of crypts; 3 points: lamina propria has obvious neutrophilic leukocyte (10 ~ 50/HP) to infiltrate, and involves more than 50% crypts; 6 points: lamina propria has a large amount of neutrophilic leukocyte (>50/HP) to infiltrate, companion's crypt abscess; 12 points: lamina propria has obvious acute inflammation to accompany ulcer.

4, statistical procedures

Enumeration data adopts x ²inspection, measurement data t checks, and ranked data Ridit analyzes, and all data acquisition SPSS statistical softwares (SPSS13.0) are analyzed.

5, result

5.1 liang of group Clinical efficacy comparisons are in table 2.

Table 2 liang group Clinical efficacy comparison [example (%)]

Group	n	Cure	Effectively	Invalid	Total effective rate
						Elm Herba Amaranthi tricoloris side group	30	23（76.67%）	5（16.67%）	2（6.67%）	93.30%
Matched group	30	20（70.00%）	6（20.00%）	4（13.33%）	86.67%

Visible, elm Herba Amaranthi tricoloris side group curative effect obviously work is better than matched group (P<0.05).

5.2 Chinese medicine syndrome integral compare in table 3.

A table 3 liang group integration improvement is compared (± s)

Group	n	Sum up before treatment and divide	Total mark after treatment
				Elm Herba Amaranthi tricoloris side group	30	12.35±3.12	5.60±1.69
Matched group	30	12.97±4.05	7.91±2.62

After two groups of treatments, result carries out statistical analysis, and difference has statistical significance (P<0.05), and the improvement of prompting elm Herba Amaranthi tricoloris side group to tcm syndrome is obviously better than matched group; After two groups of treatments, syndrome integral is all significantly improved (P<0.05); Compare with matched group, treatment group integration improves significantly (P<0.05).

5.3 symptoms are improved situation and are compared

After elm Herba Amaranthi tricoloris side group and matched group patient treatment, the symptom such as stomachache, diarrhoea, Mucous Stool is all significantly improved; Compare no significant difference (P<0.05) for two groups.

5.4SutherlandDAI scoring is compared

After two groups of treatments, SutherlandDAI declines (P<0.01) before all comparatively treating, and after treatment, elm Herba Amaranthi tricoloris side group is lower than matched group (P<0.01), in table 4.

5.5 intestinal mirror situations changes are compared

Two groups for the treatment of postcolon mirror performance scorings decline (P<0.01) before all comparatively treating, and after treatment, elm Herba Amaranthi tricoloris side group is lower than matched group (P<0.01), in table 4.

5.6 colon's pathological change situations compare

Two groups for the treatment of hindgut histo pathological changes scoring all comparatively front decline (P<0.01) for the treatment of, after treatment, elm Herba Amaranthi tricoloris side group is lower than matched group (P<0.01), in table 4.

Before and after table 4 liang group treatment, SutherlandDAI, the performance of intestinal mirror and colon's pathological change scoring are compared

Group	Time	Sutherland DAI	Intestinal mirror shows	Colon's pathological change
					Matched group	Before treatment	7.58±1.79	7.11±2.19	8.09±2.23
	After treatment	3.02±1.05△	4.19±1.67△	3.98±2.02△
					Elm Herba Amaranthi tricoloris side group	Before treatment	7.33±1.58	6.99±2.03	8.13±2.21
	After treatment	1.45±1.01△▲	2.24±1.87△▲	2.83±2.52△▲

Note: compare △ (P<0.01) with before treatment; With compare after treatment of control group ▲ (P<0.01)

5.7 liang of group IL-10, IL-6 changes are in table 5.

Serum IL-10, IL-6 level (± s) before and after table 5 liang group treatment

Group	Time	IL-10	IL-6
				Matched group	Before treatment	66.69±6.45	197.04±13.24
	After treatment	118.05±5.17△	158.66±7.72△
				Elm Herba Amaranthi tricoloris side group	Before treatment	67.93±7.78	188.97±18.08
	After treatment	138.58±6.94△▲	138.39±6.45△▲

Note: compare △ (P<0.01) with before treatment; With compare after treatment of control group ▲ (P<0.01).

After treatment, two groups of IL-6s decline before all comparatively treating, and after treatment, elm Herba Amaranthi tricoloris side group IL-6 is lower than matched group (P<0.01).After treatment, two groups of serum IL-10s rise before all comparatively treating, and after treatment, treatment group serum IL-10 is higher than matched group (P<0.01).

6, untoward reaction

4 examples are had to occur untoward reaction at treatments period matched group; Main manifestations is loss of appetite, Nausea and vomiting, and incidence rate is 13.3%; Equal warp suitably processes improvement, non-therapy discontinued.Any untoward reaction and toxic and side effects is there is not in elm Herba Amaranthi tricoloris side group during medication.

Claims

1. treat a coloclysis Chinese medicine composition for ulcerative colitis, it is characterized in that, the said composition weight preparing material used is: Radix Sanguisorbae 45-55 gram, Herba portulacae 45-55 gram, Herba Agrimoniae 45-55 gram, Radix Pulsatillae 45-55 gram, Cortex Fraxini 45-55 gram, Cortex Phellodendri 45-55 gram, Pseudobulbus Bletillae (Rhizoma Bletillae) 5-15 gram, Semen Coicis 45-55 gram, Rhizoma Acori Graminei 40-50 gram, Rhizoma Atractylodis 40-50 gram, Rhizoma Imperatae 40-50 gram, Alumen 1-3 gram.

2. a kind of coloclysis Chinese medicine composition for the treatment of ulcerative colitis according to claim 1, is characterized in that, the said composition weight preparing material used is: Radix Sanguisorbae 48-53 gram, Herba portulacae 48-53 gram, Herba Agrimoniae 48-53 gram, Radix Pulsatillae 48-53 gram, Cortex Fraxini 48-53 gram, Cortex Phellodendri 48-53 gram, Pseudobulbus Bletillae (Rhizoma Bletillae) 8-13 gram, Semen Coicis 48-53 gram, Rhizoma Acori Graminei 43-48 gram, Rhizoma Atractylodis 43-48 gram, Rhizoma Imperatae 43-48 gram, Alumen 1.5-2.5 gram.

3. a kind of coloclysis Chinese medicine composition for the treatment of ulcerative colitis according to claim 1, is characterized in that, the said composition weight preparing material used is: Radix Sanguisorbae 50 grams, Herba portulacae 50 grams, Herba Agrimoniae 50 grams, the Radix Pulsatillae 50 grams, Cortex Fraxini 50 grams, Cortex Phellodendri 50 grams, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10 grams, Semen Coicis 50 grams, Rhizoma Acori Graminei 50 grams, Rhizoma Atractylodis 50 grams, Rhizoma Imperatae 40 grams, 1 gram, Alumen.

4. a kind of coloclysis Chinese medicine composition for the treatment of ulcerative colitis according to claim 1, is characterized in that, the said composition weight preparing material used is: Radix Sanguisorbae 50 grams, Herba portulacae 50 grams, Herba Agrimoniae 50 grams, the Radix Pulsatillae 50 grams, Cortex Fraxini 50 grams, Cortex Phellodendri 50 grams, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10 grams, Semen Coicis 50 grams, Rhizoma Acori Graminei 40 grams, Rhizoma Atractylodis 40 grams, Rhizoma Imperatae 50 grams, 3 grams, Alumen.

5. a kind of preparation method for the treatment of the coloclysis Chinese medicine composition of ulcerative colitis according to claim 1-5, it is characterized in that, use clear water 500mL, after above-mentioned raw material of Chinese medicine is soaked 40 clocks, decoct 10 minutes with high heat, then with 20 minutes at a simmer, densely decoct to 100mL, then with fried medicinal liquid retention enema, every day 1 time.