CN102727816B - Traditional Chinese medicine composition used for treating ulcerative colitis - Google Patents
Traditional Chinese medicine composition used for treating ulcerative colitis Download PDFInfo
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- CN102727816B CN102727816B CN 201210222154 CN201210222154A CN102727816B CN 102727816 B CN102727816 B CN 102727816B CN 201210222154 CN201210222154 CN 201210222154 CN 201210222154 A CN201210222154 A CN 201210222154A CN 102727816 B CN102727816 B CN 102727816B
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Abstract
The invention relates to a traditional Chinese medicine composition used for treating ulcerative colitis. Ulcerative colitis (UC) is an inflammatory disease happening at colon and rectum parts. The causes of UC are complicated, and UC is one of clinical incurable diseases. The disease is caused by intrinsic dampness. Evils of dampness and heat toxin attack the intestines, and a struggle is held between the vital energy and the evils. Under the struggle, even intestinal mucosa carbuncle ulcers are caused. Aiming at the problem, the medicine composition provided by the invention adopts traditional Chinese medicines with heat clearing, dampness eliminating, and pain prioritizing functions, such as large angiopteris rhizome, dandelion, medicinal fatheadtree stem and bark, ash bark, wilson barberry root, largehead atractylodes rhizome, red peony root, hispid Chinese knotweed root, rhubarb, and tsao-ko amomum fruit. The traditional Chinese medicines are prepared into an enema. As a result of clinical experiments in our hospital, a total effective rate reaches 96.7%. The total effective rate and clinical improvement conditions are better than a control group. Therefore, the traditional Chinese medicine composition is worthy of clinical application.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine composition for the treatment of ulcerative colitis.
Background technology
Ulcerative colitis (UC) is a kind of agnogenic chronic colitis, and sickness rate is 5/10000ths.China's sickness rate is lower, but on the rise in recent years.The treatment ulcerative colitis mainly is the oral and rectally of sulfasalazine (SASP), 5-aminosalicylic acid (5-ASA) at present, because dose for oral use is large, therefore easily cause more side reaction, the pathological changes that furthermore is positioned at colon section far away adopts oral medication, and curative effect is unsatisfactory.Oral 5-ASA slow releasing agent has certain curative effect, but price is high, and the life-time service patient is difficult to bear.We are by clinical observation, think Chinese medicine composition retention-enema treatment ulcerative colitis determined curative effect.And simple to operate, patient is painful little, evident in efficacy, cheap, acceptant.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine composition for the treatment of ulcerative colitis, ulcerative colitis (UC) is a kind of inflammatory diseases that occurs in knot, rectum position of cause of disease complexity, is clinical one large difficult miscellaneous diseases.Ulcerative colitis belongs to the sick category of Chinese medicine " dysentery ".Its card belongs to retention of damp-heat in the interior person, is that heresy of turbid damp, pyretic toxicity won and hit intestinal, struggle between vital QI and pathogen, and very the person forms intestinal mucosa carbuncle and ulcer and ulceration.Control and work as with clearing heat and expelling damp relieving spasm to stop pain.
The objective of the invention is to be achieved through the following technical solutions, the Chinese medicine composition of this treatment ulcerative colitis is made by the Chinese medicine of following weight portion: Angiopteris magna Ching (Angiopteris majuscula Ching) 20-25 part, Herba Taraxaci 20-25 part, Lignum et Radix Naucleae 15-20 part, Cortex Fraxini 15-20 part, Radix Berberidis wilsonae 7-10 part, Rhizoma Atractylodis Macrocephalae 15-20 part, Radix Paeoniae Rubra 15-18 part, Radix Polygoni hispidi 15-20 part, Radix Et Rhizoma Rhei 7-9 part, Fructus Tsaoko 10-15 part.
Preferably, 23 parts of Angiopteris magna Ching (Angiopteris majuscula Ching)s, 23 parts of Herba Taraxacis, 18 parts of Lignum et Radix Naucleae, 18 parts of Cortex Fraxinis, 9 parts of Radix Berberidis wilsonae, 18 parts of the Rhizoma Atractylodis Macrocephalaes, 16 parts of Radix Paeoniae Rubra, 18 parts of Radix Polygoni hispidis, 8 parts of Radix Et Rhizoma Rhei, 13 parts of Fructus Tsaokos.
In the side: Angiopteris magna Ching (Angiopteris majuscula Ching): enter the heart, lung, large intestine three warps; Heat-clearing and toxic substances removing, the diuresis damp eliminating, promoting blood circulation and hemostasis, disappearing stagnates except swollen, controls enteritis, dysentery.
Herba Taraxaci: return liver, the stomach warp; Heat-clearing and toxic substances removing, the eliminating carbuncle eliminating stagnation, dampness removing is treating stranguria.
Lignum et Radix Naucleae: heat-clearing and toxic substances removing, reducing swelling and alleviating pain is used for urinary system infection, enteritis, dysentery, cholecystitis.
Cortex Fraxini: enter liver, kidney two warps; Heat clearing and damp drying, antiasthmatic-antitussive makes eye bright; Control bacillary dysentery, enteritis, leucorrhea, chronic tracheitis.
Radix Berberidis wilsonae: return liver, stomach, large intestine channel; Heat clearing and damp drying, eliminating fire and detoxication.
The Rhizoma Atractylodis Macrocephalae: return spleen, stomach warp; Air making-up and spleen enlivening, the dampness diuretic, hidroschesis, antiabortive.
Radix Paeoniae Rubra: return Liver Channel; Clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling, pain relieving.
Radix Polygoni hispidi: restore menstrual flow and invigorate blood circulation hemostasis, detoxifcation; Control enteritis.
Radix Et Rhizoma Rhei: return spleen, stomach, large intestine, liver, pericardium channel; Heat and toxic materials clearing away, clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body, blood circulation promoting and blood stasis dispelling.
Fructus Tsaoko: enter spleen, stomach two warps; Dampness is except cold, and preventing the attack (or recurrence) of malaria eliminates the phlegm.
Clinical data
1, the physical data all cases is in November, 2009~2010 this Out-patient Department in year August and inpatient, select light, moderate UC (total colectomy and rectum type) patient's 158 examples, by medical and include serial number in, with the study subject random assortment to treatment group and matched group.Treatment group 92 examples, male 56 examples wherein, women 36 examples; 21~66 years old age, average 45.9 ± 3.6 years old; The course of disease 4~55 months, average 21.6 ± 2.4 months; State of an illness moderate 38 examples, slight 54 examples.Matched group 66 examples, male 28 examples, women 38 examples; 22~67 years old age, average 46.7 ± 3.2 years old; The course of disease 5~56 months, average 20.9 ± 2.6 months; State of an illness moderate 30 examples, slight 36 examples.Two groups of patient ages, the course of disease, state of an illness comparing difference not statistically significant (P>0.05), two groups have comparability.
2, diagnostic criteria tcm diagnosis standard: " new Chinese medicine clinical research guide " that tcm diagnosis standard reference National Drug Administration promulgates carries out.Retention of damp-heat in the interior type UC primary symptom: diarrhoea, bloody purulent stool, tenesmus, scorching hot, the heating of stomachache; Inferior disease: burning sensation of the anus, urinate red; Red tongue with yellowish and greasy fur, slippery and rapid pulse or moisten number.
3, the Therapeutic Method treatment group is used Chinese medicine composition of the present invention, after fully shaking up, each medicinal liquid 80ml that extracts, fluid temperature and human body temperature are adapted to suitable, retention enema, 1 time every night, matched group: 1h allows patient's rest 20min~30min with behind the warm saline cleansing enema just before going to bed every night, metronidazole injection 80ml is added the medicinal liquid of XILEI SAN 1.0g, select 16~No. 18 importings, advise the emptying stool of patient before sleeping, left lateral position is according to colonoscope finding pathological changes intestinal segment, adjust position, every day is a retention enema greatly after an action of the bowels.Two groups equal 7 days be a course for the treatment of.
4, criterion of therapeutical effect is with reference to Chengdu in 2000 " national inflammatory bowel scientific seminar " standard (1) produce effects (or alleviating fully): clinical symptom disappearance, colonoscope check mucosa is roughly normal.Drug withdrawal or only do not recur in 6 months with the maintenance dose observed drug.(2) effective: clinical symptoms disappears substantially, and the mild inflammation reaction of colonoscope check mucosa and part pseudopolyp form.(3) invalid: clinical symptoms, scope and pathologic finding are all without improving.
5, Clinical efficacy comparison sees Table 1 after two weeks of (1) two group for the treatment of of therapeutic outcome.
Table 1 liang group Clinical efficacy comparison
Compare P<0.05 with matched group
The treatment group total effective rate is 96.7%, and the matched group total effective rate is that 80.3%, two group of total effective rate, cure rate obviously are better than matched group, and two groups relatively, and difference has significant (P<0.05).
The colonoscopy result relatively sees Table 2 before and after (2) two groups of treatments.Treat two groups of postcolon microscopy results and compare, difference has significant (P<0.05).
Ulcer colonoscope result relatively before and after the table 2 liang group treatment
With comparison after the treatment of control group, * P<0.05
The specific embodiment
Embodiment one: take by weighing Angiopteris magna Ching (Angiopteris majuscula Ching) 23g, Herba Taraxaci 23g, Lignum et Radix Naucleae 18g, Cortex Fraxini 18g, Radix Berberidis wilsonae 9g, Rhizoma Atractylodis Macrocephalae 18g, Radix Paeoniae Rubra 16g, Radix Polygoni hispidi 18g, Radix Et Rhizoma Rhei 8g, Fructus Tsaoko 13g.Make according to a conventional method enema.Before the coloclysis, fully shake up rear each extraction medicinal liquid 90ml, fluid temperature and human body temperature are adapted to suitable, retention enema, 1 time every night.Advise the emptying stool of patient before sleeping, left lateral position according to colonoscope finding pathological changes intestinal segment, is adjusted position.
Embodiment two: take by weighing Angiopteris magna Ching (Angiopteris majuscula Ching) 20g, Herba Taraxaci 20g, Lignum et Radix Naucleae 15g, Cortex Fraxini 15g, Radix Berberidis wilsonae 7g, Rhizoma Atractylodis Macrocephalae 15g, Radix Paeoniae Rubra 15g, Radix Polygoni hispidi 15g, Radix Et Rhizoma Rhei 7g, Fructus Tsaoko 10g.Make according to a conventional method enema.Before the coloclysis, fully shake up rear each extraction medicinal liquid 90ml, fluid temperature and human body temperature are adapted to suitable, retention enema, 1 time every night.Advise the emptying stool of patient before sleeping, left lateral position according to colonoscope finding pathological changes intestinal segment, is adjusted position.
Embodiment three: take by weighing Angiopteris magna Ching (Angiopteris majuscula Ching) 25g, Herba Taraxaci 25g, Lignum et Radix Naucleae 20g, Cortex Fraxini 20g, Radix Berberidis wilsonae 10g, Rhizoma Atractylodis Macrocephalae 20g, Radix Paeoniae Rubra 18g, Radix Polygoni hispidi 20g, Radix Et Rhizoma Rhei 9g, Fructus Tsaoko 15g.Make according to a conventional method enema.Before the coloclysis, fully shake up rear each extraction medicinal liquid 90ml, fluid temperature and human body temperature are adapted to suitable, retention enema, 1 time every night.Advise the emptying stool of patient before sleeping, left lateral position according to colonoscope finding pathological changes intestinal segment, is adjusted position.
Claims (2)
1. Chinese medicine composition for the treatment of ulcerative colitis, it is characterized in that this Chinese medicine composition made by the Chinese medicine of following weight portion: Angiopteris magna Ching (Angiopteris majuscula Ching) 20-25 part, Herba Taraxaci 20-25 part, Lignum et Radix Naucleae 15-20 part, Cortex Fraxini 15-20 part, Radix Berberidis wilsonae 7-10 part, Rhizoma Atractylodis Macrocephalae 15-20 part, Radix Paeoniae Rubra 15-18 part, Radix Polygoni hispidi 15-20 part, Radix Et Rhizoma Rhei 7-9 part, Fructus Tsaoko 10-15 part, make according to a conventional method enema, before the coloclysis, fully shake up rear each extraction medicinal liquid 90ml, fluid temperature and human body temperature are adapted to suitable, retention enema, 1 time every night.
2. a kind of Chinese medicine composition for the treatment of ulcerative colitis according to claim 1 is characterized in that this Chinese medicine composition made by the Chinese medicine of following weight portion: 23 parts of Angiopteris magna Ching (Angiopteris majuscula Ching)s, 23 parts of Herba Taraxacis, 18 parts of Lignum et Radix Naucleae, 18 parts of Cortex Fraxinis, 9 parts of Radix Berberidis wilsonae, 18 parts of the Rhizoma Atractylodis Macrocephalaes, 16 parts of Radix Paeoniae Rubra, 18 parts of Radix Polygoni hispidis, 8 parts of Radix Et Rhizoma Rhei, 13 parts of Fructus Tsaokos.
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CN101757542A (en) * | 2010-04-07 | 2010-06-30 | 泰一和浦(北京)中医药研究院有限公司 | Traditional Chinese medicine composition for treating colonitis and preparation method |
CN101766774A (en) * | 2010-04-07 | 2010-07-07 | 泰一和浦(北京)中医药研究院有限公司 | Chinese medicine composite for treating duodenal ulcer and preparation method thereof |
CN101773633A (en) * | 2010-04-08 | 2010-07-14 | 泰一和浦(北京)中医药研究院有限公司 | Chinese medicine composition for treating gastric ulcer and preparation method thereof |
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CN101757542A (en) * | 2010-04-07 | 2010-06-30 | 泰一和浦(北京)中医药研究院有限公司 | Traditional Chinese medicine composition for treating colonitis and preparation method |
CN101766774A (en) * | 2010-04-07 | 2010-07-07 | 泰一和浦(北京)中医药研究院有限公司 | Chinese medicine composite for treating duodenal ulcer and preparation method thereof |
CN101773633A (en) * | 2010-04-08 | 2010-07-14 | 泰一和浦(北京)中医药研究院有限公司 | Chinese medicine composition for treating gastric ulcer and preparation method thereof |
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