CN103110816B

CN103110816B - Chinese herba preparation for treating chronic ulcerative colitis

Info

Publication number: CN103110816B
Application number: CN201310048170.2A
Authority: CN
Inventors: 郭传智
Original assignee: Individual
Current assignee: Individual
Priority date: 2013-01-24
Filing date: 2013-01-24
Publication date: 2014-10-22
Anticipated expiration: 2033-01-24
Also published as: CN103110816A

Abstract

The invention discloses a Chinese herba preparation for treating chronic ulcerative colitis. In the traditional Chinese medicine, the chronic ulcerative colitis is categorized as dysentery, diarrhea and intestinal afflux, and caused by dysfunction of the spleen in transport, internal hot and humid condition, large intestine hot-damp accumulation, intestial injury and sepsis syndrome due to eating disorder and emotional disorder and overwork. In order to solve the problems, the Chinese herba preparation is decocted into decoction in preparation department by adopting the following traditional Chinese materials: white flower cacalia seed, sedum sarmentosum, abutilon fiber, manyleaf meadowure rhizome and root, salvia chinensis, mock-strawberry, verbena, tropaeolum, potentilla cryptotaeniae, humifuse euphorbia herb, campsis grandiflora, panax japonicas, folium callicarpae pedunculatae, white atractylodes rhizome, rhizoma polygonati, arillus longan and liquorice. According to the clinical test, the total effective rate is 95.6%, and the recovery rate and colonoscopy results before and after the treatment are remarkably better than those of the control group.

Description

A kind of Chinese medicine preparation for the treatment of chronic ulcerative colitis

Technical field

The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine preparation for the treatment of chronic ulcerative colitis.

Background technology

Chronic ulcerative colitis claims again inflammatory enteritis, is a kind of agnogenic rectum and colon disease, belongs to the difficult diseases of digestive system, and normal easily recurrence, and has dependency with colon cancer morbidity; At present clinically adopt aminosalicylic acids and the solid acids Drug therapy of cortex class more, but there is bounce-back after drug withdrawal, the shortcoming such as curative effect is unstable, long-term prescription side effect is larger.The author proves through clinical trial for many years, adopts rational Treated with Chinese Decoction chronic ulcerative colitis to have good effect, and stable curative effect, the advantage that side effect is little.

Summary of the invention

The object of this invention is to provide a kind of Chinese medicine preparation for the treatment of chronic ulcerative colitis.The categories such as primary disease belongs to Chinese medicine dysentery, has loose bowels, morbid state, sick position is at spleen, stomach, large intestine, the cause of disease be diet, disorder of emotion, overworked, cause dysfunction of the spleen in transportation, damp and hot interior life, pents up large intestine, damage intestinal, the rotten blood of meat loses and causes a disease.

The object of the invention is to be achieved through the following technical solutions, the Chinese medicine preparation of this treatment chronic ulcerative colitis is made by the Chinese medicine of following weight portion: Semen Caesalpiniae Minacis 2-7 part, Herba Sedi 3-9 part, Semen Abutili 3-5 part, Radix et Rhizoma Thalictri 5-9 part, Herba Salviae Chinensis 2.5-7.5 part, Herba Duchesneae Indicae 3-8 part, Herba Verbenae 5-10 part, Flos Trollii 4-7 part, Herba Agrimoniae Herba Potentillae Chinensis 3-5 part, Herba Euphorbiae Humifusae 2-6 part, Flos Campsis 1-3 part, Rhizoma Panacis Japonici 1.5-6.5 part, Folium Callicarpae Formosanae 3-6 part, Rhizoma Atractylodis Macrocephalae 5-15 part, Rhizoma Polygonati 10-20 part, Arillus Longan 5-9 part, Radix Glycyrrhizae 3-5 part.

Preferably, 5 parts of Semen Caesalpiniae Minaciss, 6 parts of Herba Sedis, 4 parts of Semen Abutilis, 7 parts of Radix et Rhizoma Thalictri, 4.5 parts of Herba Salviae Chinensiss, 6 parts of Herba Duchesneae Indicaes, 8 parts of Herba Verbenae, 5 parts of Flos Trolliis, 4 parts of Herba Agrimoniae Herba Potentillae Chinensis, 5 parts of Herba Euphorbiae Humifusaes, 2 parts of Flos Campsiss, 3.5 parts of Rhizoma Panacis Japonicis, 4 parts of Folium Callicarpae Formosanaes, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 15 parts of Rhizoma Polygonatis, 7 parts of Arillus Longans, 4 parts, Radix Glycyrrhizae.

Preparation method is by traditional preparation method, and decocting is made decoction.

In side: Semen Caesalpiniae Minacis, Herba Salviae Chinensis, Herba Duchesneae Indicae, Flos Trollii clearing away heat and eliminating dampness, dissipating blood stasis for subsidence of swelling, regulating QI to relieve pain; Herba Sedi, Semen Abutili, Radix et Rhizoma Thalictri eliminating damp-heat, removing toxic substances; Herba Agrimoniae Herba Potentillae Chinensis, Herba Euphorbiae Humifusae, Folium Callicarpae Formosanae promoting blood circulation and hemostasis, removing toxic substances sore; Herba Verbenae, Flos Campsis dissipating blood stasis to promote menstruationg, cooling blood, expelling wind, inducing diuresis to remove edema; The Rhizoma Atractylodis Macrocephalae, Rhizoma Polygonati air making-up and spleen enlivening, nourishing kidney lung moistening, dampness diuretic; Rhizoma Panacis Japonici strengthening by means of tonics, eliminating stasis to stop pain; Arillus Longan invigorating the heart and spleen, nourishing blood to tranquillize the mind; The invigorating middle warmer of Radix Glycyrrhizae QI invigorating, heat-clearing and toxic substances removing, alleviates pain relieving.

Clinical data

1, this group of physical data case is this Out-patient Department and inpatient, selects light, moderate, severe, and patient's 92 examples, are divided into treatment group and matched group at random, treatment group 46 examples, male 26 examples wherein, female's 20 examples; 20～65 years old age, average 45.8 ± 3.5 years old; The course of disease 5～56 months, average 21.5 ± 2.5 months; 14 examples that the state of an illness is slight, moderate 23 examples, severe 9 examples, it is main 32 examples that mucosa infection be take sigmoid colon and rectum, accumulative total left side colon 14 examples.Matched group 46 examples, male 25 examples, female's 21 examples; 21～66 years old age, average 46.0 ± 3.4 years old; The course of disease 6～55 months, average 20.5 ± 2.7 months; 15 examples that the state of an illness is slight, moderate 24 examples, severe 7 examples, it is main 31 examples that mucosa infection be take sigmoid colon and rectum, accumulative total left side colon 15 examples, the inspection of two groups of excrement and the antibacterial culturing body that all do not find the cause of disease, patient age, the course of disease, state of an illness comparing difference not statistically significant (P>0.05), two groups have comparability.

2, diagnostic criteria is with reference to the up-to-date domestic and international Disease Diagnosis Standard > > of < <: all have diarrhoea in various degree, every day 2-10 time is not etc., the aobvious mucosanguineous feces of stool or rare watery stool, companion's stomachache, abdominal distention, borborygmus, weak, poor appetite etc.Stool checks visible pus cell or erythrocyte, the visible mucous hyperemia of fibercolonscopy, edema, hemorrhage, and have a plurality of ulcer that size and form is different, be coated with HUANGBAI(sic) or blood effusion.

3, Therapeutic Method treatment group is taken Chinese medicine preparation of the present invention, prescription is: Semen Caesalpiniae Minacis 5g, Herba Sedi 6g, Semen Abutili 4g, Radix et Rhizoma Thalictri 7g, Herba Salviae Chinensis 4.5g, Herba Duchesneae Indicae 6g, Herba Verbenae 8g, Flos Trollii 5g, Herba Agrimoniae Herba Potentillae Chinensis 4g, Herba Euphorbiae Humifusae 5g, Flos Campsis 2g, Rhizoma Panacis Japonici 3.5g, Folium Callicarpae Formosanae 4g, Rhizoma Atractylodis Macrocephalae 10g, Rhizoma Polygonati 15g, Arillus Longan 7g, Radix Glycyrrhizae 4g, decocting is made decoction, every day, potion, divided morning, 2 sub-services in evening; The oral sulfasalazine sheet of matched group, adult 3 grams of every days, minute takes for 3 times; Two groups equal 3 weeks is a course for the treatment of.

4, criterion of therapeutical effect is with reference to the up-to-date domestic and international disease treatment standard > > of < <: Short Term Clinical is cured: transference cure, fiber colon check mucosa is normal, drug withdrawal or only use maintenance dose medicine, observes 6 months without recurrence; Effective: clinical symptoms disappears substantially, fibro-colonoscope check has mild inflammation reaction and the false meat of part to form; Invalid: after treatment, clinical symptoms and endoscopy are without improvement.

5,3 weeks rear Clinical efficacy comparisons of (1) two group for the treatment of of therapeutic outcome are in Table 1.

Table 1 liang group Clinical efficacy comparison

With matched group comparison, * P<0.05

Treatment group total effective rate is 95.6%, and matched group total effective rate is 80.43%, and treatment group total effective rate, cure rate are obviously better than matched group, two groups of comparisons, and difference has significant (P<0.05).

Before and after (2) two groups of treatments, colonoscopy result is relatively in Table 2.Two groups of comparisons for the treatment of postcolon microscopy result, difference has significant (P<0.05).

Colonoscope result comparison before and after table 2 liang group treatment

With comparison after treatment of control group, * P<0.05

The specific embodiment

Embodiment mono-: take Semen Caesalpiniae Minacis 5g, Herba Sedi 6g, Semen Abutili 4g, Radix et Rhizoma Thalictri 7g, Herba Salviae Chinensis 4.5g, Herba Duchesneae Indicae 6g, Herba Verbenae 8g, Flos Trollii 5g, Herba Agrimoniae Herba Potentillae Chinensis 4g, Herba Euphorbiae Humifusae 5g, Flos Campsis 2g, Rhizoma Panacis Japonici 3.5g, Folium Callicarpae Formosanae 4g, Rhizoma Atractylodis Macrocephalae 10g, Rhizoma Polygonati 15g, Arillus Longan 7g, Radix Glycyrrhizae 4g, decocting is made decoction.

Embodiment bis-: take Semen Caesalpiniae Minacis 2g, Herba Sedi 9g, Semen Abutili 3g, Radix et Rhizoma Thalictri 5g, Herba Salviae Chinensis 7.5g, Herba Duchesneae Indicae 3g, Herba Verbenae 10g, Flos Trollii 4g, Herba Agrimoniae Herba Potentillae Chinensis 5g, Herba Euphorbiae Humifusae 2g, Flos Campsis 3g, Rhizoma Panacis Japonici 1.5g, Folium Callicarpae Formosanae 6g, Rhizoma Atractylodis Macrocephalae 5g, Rhizoma Polygonati 20g, Arillus Longan 5g, Radix Glycyrrhizae 3g, decocting is made decoction.

Embodiment tri-: take Semen Caesalpiniae Minacis 7g, Herba Sedi 3g, Semen Abutili 5g, Radix et Rhizoma Thalictri 9g, Herba Salviae Chinensis 2.5g, Herba Duchesneae Indicae 8g, Herba Verbenae 5g, Flos Trollii 7g, Herba Agrimoniae Herba Potentillae Chinensis 3g, Herba Euphorbiae Humifusae 6g, Flos Campsis 1g, Rhizoma Panacis Japonici 6.5g, Folium Callicarpae Formosanae 3g, Rhizoma Atractylodis Macrocephalae 15g, Rhizoma Polygonati 10g, Arillus Longan 9g, Radix Glycyrrhizae 5g, decocting is made decoction.

Claims

1. treat a Chinese medicine preparation for chronic ulcerative colitis, it is characterized in that this Chinese medicine preparation made by the Chinese medicine of following weight: Semen Caesalpiniae Minacis 5g, Herba Sedi 6g, Semen Abutili 4g, Radix et Rhizoma Thalictri 7g, Herba Salviae Chinensis 4.5g, Herba Duchesneae Indicae 6g, Herba Verbenae 8g, Flos Trollii 5g, Herba Agrimoniae Herba Potentillae Chinensis 4g, Herba Euphorbiae Humifusae 5g, Flos Campsis 2g, Rhizoma Panacis Japonici 3.5g, Folium Callicarpae Formosanae 4g, Rhizoma Atractylodis Macrocephalae 10g, Rhizoma Polygonati 15g, Arillus Longan 7g, Radix Glycyrrhizae 4g.