CN103720877B - A kind of Chinese medicine preparation for the treatment of chronic ulcerative colitis - Google Patents
A kind of Chinese medicine preparation for the treatment of chronic ulcerative colitis Download PDFInfo
- Publication number
- CN103720877B CN103720877B CN201310751494.2A CN201310751494A CN103720877B CN 103720877 B CN103720877 B CN 103720877B CN 201310751494 A CN201310751494 A CN 201310751494A CN 103720877 B CN103720877 B CN 103720877B
- Authority
- CN
- China
- Prior art keywords
- chinese medicine
- radix
- ulcerative colitis
- treatment
- medicine preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000003814 drug Substances 0.000 title claims abstract description 17
- 206010009900 Colitis ulcerative Diseases 0.000 title claims abstract description 11
- 201000006704 Ulcerative Colitis Diseases 0.000 title claims abstract description 11
- 230000001684 chronic effect Effects 0.000 title claims abstract description 10
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- 241001441970 Anserinae Species 0.000 claims abstract description 9
- 241000504539 Pedicularis henryi Species 0.000 claims abstract description 9
- 241001617284 Pedicularis rex Species 0.000 claims abstract description 9
- 230000003203 everyday effect Effects 0.000 claims description 5
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 5
- 230000000968 intestinal effect Effects 0.000 abstract description 8
- 239000008280 blood Substances 0.000 abstract description 6
- 230000000694 effects Effects 0.000 abstract description 6
- 206010012735 Diarrhoea Diseases 0.000 abstract description 5
- 210000000952 spleen Anatomy 0.000 abstract description 5
- 210000004369 blood Anatomy 0.000 abstract description 4
- 208000037920 primary disease Diseases 0.000 abstract description 4
- 210000002784 stomach Anatomy 0.000 abstract description 4
- 208000033809 Suppuration Diseases 0.000 abstract description 2
- 210000001835 viscera Anatomy 0.000 abstract description 2
- 238000007905 drug manufacturing Methods 0.000 abstract 1
- 208000025865 Ulcer Diseases 0.000 description 5
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 231100000397 ulcer Toxicity 0.000 description 4
- 230000013872 defecation Effects 0.000 description 3
- 210000004347 intestinal mucosa Anatomy 0.000 description 3
- 206010000087 Abdominal pain upper Diseases 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- NCEXYHBECQHGNR-UHFFFAOYSA-N chembl421 Chemical compound C1=C(O)C(C(=O)O)=CC(N=NC=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-UHFFFAOYSA-N 0.000 description 2
- 210000001072 colon Anatomy 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 210000000664 rectum Anatomy 0.000 description 2
- 230000000306 recurrent effect Effects 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 241000792859 Enema Species 0.000 description 1
- 208000004232 Enteritis Diseases 0.000 description 1
- 206010016654 Fibrosis Diseases 0.000 description 1
- 206010062016 Immunosuppression Diseases 0.000 description 1
- 206010057071 Rectal tenesmus Diseases 0.000 description 1
- 102100033717 Retroviral-like aspartic protease 1 Human genes 0.000 description 1
- 101710188689 Small, acid-soluble spore protein 1 Proteins 0.000 description 1
- 101710188693 Small, acid-soluble spore protein 2 Proteins 0.000 description 1
- 101710166422 Small, acid-soluble spore protein A Proteins 0.000 description 1
- 101710166404 Small, acid-soluble spore protein C Proteins 0.000 description 1
- 101710174019 Small, acid-soluble spore protein C1 Proteins 0.000 description 1
- 101710174017 Small, acid-soluble spore protein C2 Proteins 0.000 description 1
- 101710174574 Small, acid-soluble spore protein gamma-type Proteins 0.000 description 1
- 208000031975 Yang Deficiency Diseases 0.000 description 1
- 208000019790 abdominal distention Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 208000027503 bloody stool Diseases 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 230000008576 chronic process Effects 0.000 description 1
- 206010009887 colitis Diseases 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 239000007920 enema Substances 0.000 description 1
- 229940095399 enema Drugs 0.000 description 1
- 230000004761 fibrosis Effects 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 208000035861 hematochezia Diseases 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 210000003405 ileum Anatomy 0.000 description 1
- 230000001506 immunosuppresive effect Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000001338 necrotic effect Effects 0.000 description 1
- 235000011837 pasties Nutrition 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 210000001599 sigmoid colon Anatomy 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 210000004876 tela submucosa Anatomy 0.000 description 1
- 208000012271 tenesmus Diseases 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses a kind of Chinese medicine preparation for the treatment of chronic ulcerative colitis.Primary disease belongs to the category that motherland's medical science " is had loose bowels ", and its sick position is mainly at intestinal.Be due to weakness of the spleen and stomach, damp and hot interior life, pents up in intestinal internal organs, and stagnation of QI-blood is burnt blood network or suppuration.The present invention selects Chinese medicine Radix potentillae anserinae, Pedicularis rex C. B. Clarke ex Maxim., Radix seu Caulis Verntilaginis Leiocarpae, Radix Pedicularis Henryi, Herba thalictri squarrosi, Folium Microcoris paniculatae, Herba Epilobii Hirsuti, Cortex Alstoniae scholaris, become decoction by my institute's Drug Manufacturing Room's decocting, through clinical trial, total effective rate reaches 94.0%, curative effect is significantly better than matched group, and side effect is little.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of Chinese medicine preparation for the treatment of chronic ulcerative colitis.
Background technology
Ulcerative colitis (UlcerativeCotitis, UC), also known as chronic non-specific ulcerative colitis or colitis idiopathic ulcerative, is one of a kind of agnogenic digestive system commonly encountered diseases.Pathological changes is mainly limited to rectum, mucous membrane of colon and tela submucosa, and in seriality, non-segmental distribution, gets involved common with rectum and sigmoid colon, relate to terminal ileum once in a while.Clinical main manifestations is stomachache, diarrhoea, mucopurulent bloody stool, tenesmus.Morbidity can be delayed and gradually or suddenly occurred, and most patient's recurrent exerbation, the course of disease is chronic process, and stage of attack and catabasis replace.Its sickness rate is in the trend risen year by year.Primary disease is protracted course of disease often, recurrent exerbation, and the later stage easily causes Colon Fibrosis, the possibility very then cancerated.Mainly react with antiinflammatory, Immunosuppression the treatment modern medicine of primary disease, anti symptom treatment and Supporting Therapy, effect is not satisfactory.Inventor utilizes treatment by Chinese herbs in clinical practice for many years, achieves good curative effect.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine preparation for the treatment of chronic ulcerative colitis.Primary disease belongs to the category that motherland's medical science " is had loose bowels ", and its sick position is mainly at intestinal.Be due to weakness of the spleen and stomach, damp and hot interior life, pents up in intestinal internal organs, and stagnation of QI-blood is burnt blood network or suppuration.
The object of the invention is to be achieved through the following technical solutions, the Chinese medicine preparation of this treatment chronic ulcerative colitis is made up of the Chinese medicine of following weight portion: Radix potentillae anserinae 25-30 part, Pedicularis rex C. B. Clarke ex Maxim. 20-25 part, Radix seu Caulis Verntilaginis Leiocarpae 23-28 part, Radix Pedicularis Henryi 15-30 part, Herba thalictri squarrosi 3-9 part, Folium Microcoris paniculatae 45-50 part, Herba Epilobii Hirsuti 13-16 part, Cortex Alstoniae scholaris 9-12 part.
Preferably, Radix potentillae anserinae 27 parts, Pedicularis rex C. B. Clarke ex Maxim. 23 parts, Radix seu Caulis Verntilaginis Leiocarpae 25 parts, Radix Pedicularis Henryi 23 parts, Herba thalictri squarrosi 6 parts, Folium Microcoris paniculatae 47 parts, Herba Epilobii Hirsuti 15 parts, Cortex Alstoniae scholaris 10 parts.
Preparation method: make decoction by traditional method decocting.
Fang Zhong: Radix potentillae anserinae, Pedicularis rex C. B. Clarke ex Maxim. vigorate qi and replenish the blood, invigorating spleen and reinforcing stomach; Radix seu Caulis Verntilaginis Leiocarpae, Radix Pedicularis Henryi benefiting vital QI and blood, strengthening bone and muscle; Herba thalictri squarrosi, Folium Microcoris paniculatae heat-clearing and toxic substances removing, stomach invigorating; The hemostasis of Herba Epilobii Hirsuti, Cortex Alstoniae scholaris is invigorated blood circulation, removing the necrotic tissue and promoting granulation, anti-inflammatory analgetic.
Clinical data
1, the routine patient of physical data 100 is all that I is in hospital and outpatient at institute, and Western medicine diagnose is chronic ulcerative colitis, and tcm diagnosis is have loose bowels (insufficiency of the spleen leading to overabundance of dampness, yang deficiency of spleen and stomache).100 routine ulcerative colitis patients are divided into two groups at random, treatment group 50 example, man 24 example, female 26 example, 19 ~ 42 years old age; Matched group 50 example, man 26 example, female 24 example, 21 ~ 42 years old age.Clinical visible hypogastric region distending pain (100%) in various degree and diarrhoea (in the pasty state, dry rare alternately), the lighter's defecation 2 ~ 4 times/d, severe one defecation 10 ~ 16 times/d.
2, diagnostic criteria (1) Western medicine diagnose standard: with reference to the whole nation, Taiyuan in 1993 " chronic noninfective intestinal tract disease scientific seminar " standard.(2) tcm diagnosis standard: with reference to " new Chinese medicine guideline of clinical investigations " (2002 May the 1st edition).
3, Therapeutic Method treatment group patient takes Chinese medicine preparation of the present invention, takes Radix potentillae anserinae 27g, Pedicularis rex C. B. Clarke ex Maxim. 23g, Radix seu Caulis Verntilaginis Leiocarpae 25g, Radix Pedicularis Henryi 23g, Herba thalictri squarrosi 6g, Folium Microcoris paniculatae 47g, Herba Epilobii Hirsuti 15g, Cortex Alstoniae scholaris 10g, every day potion, decocting extracting juice, early, evening 2 sub-services, matched group SASP is oral, 2 pieces/times, 2 times/d, SASP0.5 simultaneously, retention enema, 1 time/d, within 4 weeks, be 1 course for the treatment of, be used in conjunction and add up curative effect two courses for the treatment of.
4, curative effect determinate standard cure: the transference cures such as stomachache, abdominal distention, diet improvement, times of defecation and shape normal.Check intestinal mirror intestinal mucosa congestion and edema disappears, ulcer healing; Effective: symptom disappears substantially, stool is shaped, 2 (or) 3 times/d, check intestinal mirror intestinal mucosa congestion and edema is clearly better, and ulcer heals substantially; Take a turn for the better: symptom alleviates, check intestinal mirror endo enteritis alleviates and ulcer reduces: invalid: symptom is without disappearance or alleviate and defecate abnormal, and check intestinal mirror intestinal mucosa is congested without improving, and ulcer is without healing.
5, therapeutic outcome two groups of patient clinical comparitive study are in table 1.
Table 1 liang group patient clinical comparitive study
Treatment group is compared with matched group as can be seen from the table, and treatment group cure rate, total effective rate, be obviously better than matched group, there is significant difference, has comparability.P＞0.05。
Detailed description of the invention
Embodiment one: take Radix potentillae anserinae 23g, Pedicularis rex C. B. Clarke ex Maxim. 23g, Radix seu Caulis Verntilaginis Leiocarpae 25g, Radix Pedicularis Henryi 23g, Herba thalictri squarrosi 6g, Folium Microcoris paniculatae 47g, Herba Epilobii Hirsuti 15g, Cortex Alstoniae scholaris 10g, decoction: decocting twice, filters extracting juice 200ml, sub-service sooner or later, every day potion.
Embodiment two: take Radix potentillae anserinae 15g, Pedicularis rex C. B. Clarke ex Maxim. 20g, Radix seu Caulis Verntilaginis Leiocarpae 23g, Radix Pedicularis Henryi 30g, Herba thalictri squarrosi 3g, Folium Microcoris paniculatae 50g, Herba Epilobii Hirsuti 16g, Cortex Alstoniae scholaris 9g, decoction: decocting twice, filters extracting juice 200ml, sub-service sooner or later, every day potion.
Embodiment three: take Radix potentillae anserinae 30g, Pedicularis rex C. B. Clarke ex Maxim. 25g, Radix seu Caulis Verntilaginis Leiocarpae 28g, Radix Pedicularis Henryi 15g, Herba thalictri squarrosi 9g, Folium Microcoris paniculatae 45g, Herba Epilobii Hirsuti 13g, Cortex Alstoniae scholaris 12g, decoction: decocting twice, filters extracting juice 200ml, sub-service sooner or later, every day potion.
Claims (1)
1. treat the Chinese medicine preparation of chronic ulcerative colitis for one kind, it is characterized in that this Chinese medicine preparation is made up of the Chinese medicine of following weight: Radix potentillae anserinae 27g, Pedicularis rex C. B. Clarke ex Maxim. 23g, Radix seu Caulis Verntilaginis Leiocarpae 25g, Radix Pedicularis Henryi 23g, Herba thalictri squarrosi 6g, Folium Microcoris paniculatae 47g, Herba Epilobii Hirsuti 15g, Cortex Alstoniae scholaris 10g, every day potion, decocting extracting juice, early, evening 2 sub-services.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310751494.2A CN103720877B (en) | 2013-12-22 | 2013-12-22 | A kind of Chinese medicine preparation for the treatment of chronic ulcerative colitis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310751494.2A CN103720877B (en) | 2013-12-22 | 2013-12-22 | A kind of Chinese medicine preparation for the treatment of chronic ulcerative colitis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103720877A CN103720877A (en) | 2014-04-16 |
| CN103720877B true CN103720877B (en) | 2016-04-13 |
Family
ID=50445339
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310751494.2A Active CN103720877B (en) | 2013-12-22 | 2013-12-22 | A kind of Chinese medicine preparation for the treatment of chronic ulcerative colitis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103720877B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102451304B1 (en) * | 2020-09-14 | 2022-10-07 | 한국과학기술연구원 | Composition for improving psoriasis symptom comprising extract of Thalictrum squarrosum steph |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020013265A1 (en) * | 1997-09-17 | 2002-01-31 | Schwartz Marshall Z. | Method and composition for the treatment of inflammatory bowel disease |
| CN102631592A (en) * | 2012-04-02 | 2012-08-15 | 顾玉栋 | Method for preparing traditional Chinese medicine (TCM) for treating pus and blood type colitis |
| CN103110816A (en) * | 2013-01-24 | 2013-05-22 | 郭传智 | Chinese herba preparation for treating chronic ulcerative colitis |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004026839A (en) * | 2003-07-25 | 2004-01-29 | Yamanouchi Pharmaceut Co Ltd | Composition for inhibiting ulcerative colitis |
-
2013
- 2013-12-22 CN CN201310751494.2A patent/CN103720877B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020013265A1 (en) * | 1997-09-17 | 2002-01-31 | Schwartz Marshall Z. | Method and composition for the treatment of inflammatory bowel disease |
| CN102631592A (en) * | 2012-04-02 | 2012-08-15 | 顾玉栋 | Method for preparing traditional Chinese medicine (TCM) for treating pus and blood type colitis |
| CN103110816A (en) * | 2013-01-24 | 2013-05-22 | 郭传智 | Chinese herba preparation for treating chronic ulcerative colitis |
Non-Patent Citations (1)
| Title |
|---|
| 健脾益气方"健脾灵"治疗慢性溃疡性结肠炎的临床疗效与药理作用研究;陈治水，等;《中国中西医结合学会第十八次全国消化系统疾病学术会议暨2006年全国中西医结合消化系统疾病进展学习班论文汇编》;20061231;第355-358页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103720877A (en) | 2014-04-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102188685A (en) | Externally-applied traditional Chinese medicine powder for treating diarrhea type irritable bowel syndrome and preparation method thereof | |
| CN105148024A (en) | Zhichuangling ointment and production technology | |
| CN100358568C (en) | Medicine for treating high blood pressure and its preparation method | |
| CN103720877B (en) | A kind of Chinese medicine preparation for the treatment of chronic ulcerative colitis | |
| CN102085335B (en) | Traditional Chinese medicine enema for treating ulcerative colitis | |
| CN103768357A (en) | Compound traditional Chinese medicinal composition for treating recurrent aphthous ulcer | |
| CN102727695A (en) | Traditional Chinese medicinal medicine for treating hemafecia | |
| CN105395975A (en) | Enema traditional Chinese medicine composition treating ulcerative colitis and preparation method thereof | |
| CN103393909B (en) | Chinese medicinal preparation for treating biliary calculus with cholecystitis | |
| CN102988559B (en) | Chinese medicinal enema for treating ulcerative colitis | |
| CN103768229B (en) | A kind of Chinese medicine composition for the treatment of chronic ulcerative colitis | |
| CN108310218A (en) | A kind of Chinese medicine composition for treating ulcerative colitis and preparation method thereof and purposes | |
| CN101385812B (en) | Traditional Chinese medicine composition containing epimeddium for treating dermatomyositis and preparation thereof | |
| CN104474184B (en) | A kind of drug for treating cough after common cold | |
| CN101385805B (en) | Traditional Chinese medicine composition containing cicada-shell for treating dermatomyositis and preparation thereof | |
| CN101385810B (en) | Traditional Chinese medicine composition containing chinemys reevesii for treating dermatomyositis and preparation thereof | |
| CN101385836B (en) | Traditional Chinese medicine composition containing poria cocos for treating dermatomyositis and preparation thereof | |
| CN101385820B (en) | Traditional Chinese medicine composition containing ephedra for treating dermatomyositis and preparation thereof | |
| CN104225435A (en) | Traditional Chinese medicine preparation for treating turbid phlegm obstructing type coronary heart disease | |
| CN101690771B (en) | Medicine for curing chronic enteritis | |
| CN105250710A (en) | Traditional Chinese medicine enema for treating ulcerative colitis | |
| CN1335171A (en) | Gynopathy treating Chinese medicine with functions of diminishing inflammation and eliminating spot and its prepn | |
| CN105999116B (en) | Traditional Chinese medicine enema prescription for treating chronic pelvic pain | |
| CN104857329A (en) | Clysis liquid for curing ulcerative colitis | |
| CN104547471A (en) | Medicine for treating nephritis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CB03 | Change of inventor or designer information | ||
| CB03 | Change of inventor or designer information |
Inventor after: Yue Aixia Inventor after: Wang Xinyue Inventor before: Yue Aixia Inventor before: Li Zhen |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20170308 Address after: 276400 Linyi health center, Yishui, Shandong, China, Yishui Central Hospital, No. 17, Patentee after: Yue Aixia Patentee after: Wang Xinyue Address before: 276400 Linyi health center, Yishui, Shandong, China, Yishui Central Hospital, No. 17, Patentee before: Yue Aixia |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20170602 Address after: The 1 group of Wu Yao Zhen Village in Rugao city of Jiangsu Province, 226500 banks in Nantong City Patentee after: Rugao Wu Shan Kang Hospital Address before: 276400 Linyi health center, Yishui, Shandong, China, Yishui Central Hospital, No. 17, Co-patentee before: Wang Xinyue Patentee before: Yue Aixia |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20191202 Address after: 221300 nongovernmental Industrial Park, nianzhuang Town, Pizhou City, Xuzhou City, Jiangsu Province Patentee after: Xuzhou better tool manufacturing Co., Ltd. Address before: The 1 group of Wu Yao Zhen Village in Rugao city of Jiangsu Province, 226500 banks in Nantong City Patentee before: Rugao Wu Shan Kang Hospital |