CN104857329A - Clysis liquid for curing ulcerative colitis - Google Patents
Clysis liquid for curing ulcerative colitis Download PDFInfo
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- CN104857329A CN104857329A CN201510226410.2A CN201510226410A CN104857329A CN 104857329 A CN104857329 A CN 104857329A CN 201510226410 A CN201510226410 A CN 201510226410A CN 104857329 A CN104857329 A CN 104857329A
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Abstract
The invention discloses a clysis liquid for curing the ulcerative colitis. The clysis liquid comprises, by weight, 50-63 parts of houttuynia cordata, 27-35 parts of folium mori, 30-39 parts of phoenix tree leaf, 12-18 parts of shaddock ped, 15-30 parts of cushaw stem and 15-30 parts of rhizoma phragmitis. Retention enema can be realized through the traditional Chinese medicine. The drug does not pass through the stomach and the small intestine so that the influence of gastric acid and digestive enzyme on the drug can be avoided. The drug can be absorbed through the colonic mucosa and directly acts on the focus so that the cure rate of the ulcerative colitis can be improved. No obvious side effect is found, and the cost is low.
Description
Technical field
The invention belongs to technical field of Chinese medicine, in particular to relating to a kind of enema for the treatment of ulcerative colitis.
Background technology
Ulcerative colitis belongs to one of chronic nonspecific inflammation disease, and the pathological changes of this disease is mainly at mucous membrane of colon, and the course of disease is longer, easy recurrent exerbation, comparatively difficult to the diagnosis and treatment of this disease clinically, is listed in the ranks of modern difficult treatment by WHO.The symptom such as diarrhoea, stomachache, mucopurulent bloody stool is its main clinical manifestation.The cause of disease of this disease and pathomechanism are still not very clear at present, may bring out because many factors interacts; Dysimmunity, genetic predisposition and enteric microorganism effect etc. become the main pathogenic of ulcerative colitis, various biochemical mediators, comprise various cytokine, somatomedin, adhesion molecule etc., in the immunoreation of this exception, all play extremely important effect.
At present, the focus point about Ulcerative Colitis research is the research carried out with scorching treatment medium for the immunoreation of those participation ulcerative colitiss and the cytokine of inflammatory process.Ulcerative colitis presents lasting ascendant trend in the morbidity of China, and EPDML data also shows pathogenesis of ulcerative colitis rate both domestic and external all presents the trend risen year by year, and its sickness rate has the trend risen rapidly especially in China.Some medicines of current use still lack specificity to treatment of ulcerative colitis, mainly contain that the internal medicine of salicylic acid, hormones, immunosuppressant, antibiotic, biological preparation etc. is comprehensive based on western medical treatment, nutrition supporting therapy and surgical operation etc., these treatments can not affect its natural history, and side effect in various degree is also that their uses are restricted.To in the treatment of ulcerative colitis, the final method of western medical treatment proctitis, no more than operation, causes sizable misery to the health of patient and energy.Comparatively speaking, traditional medicine and related preparations treatment thereof comparatively effectively, can not only be alleviated the clinical symptoms of ulcerative colitis, and can effectively prevent disease palindromia.
Summary of the invention
The present inventor furthers investigate and improves on the basis of folk remedy, has prepared a kind of Chinese medicinal herbs decoction, the determined curative effect of its treatment ulcerative colitis, and safe and effective.Therefore, the object of the present invention is to provide a kind of enema and application thereof for the treatment of ulcerative colitis.
The object of the present invention is achieved like this:
Treat an enema for ulcerative colitis, it is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Herba Houttuyniae 50-63 part, Folium Mori 27-35 part, Folium firmianae 30-39 part, Pericarpium Citri grandis 12-18 part, Caulis Cucurbitae 15-30 part, Rhizoma Phragmitis 15-30 part.
Preferably, the enema for the treatment of ulcerative colitis described above, it is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Herba Houttuyniae 54-58 part, Folium Mori 29-32 part, Folium firmianae 33-35 part, Pericarpium Citri grandis 14-16 part, Caulis Cucurbitae 20-24 part, Rhizoma Phragmitis 20-24 part.
Further preferably, the enema for the treatment of ulcerative colitis as mentioned above, it is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Herba Houttuyniae 56 parts, 30 parts, Folium Mori, Folium firmianae 34 parts, Pericarpium Citri grandis 15 parts, Caulis Cucurbitae 22 parts, Rhizoma Phragmitis 22 parts.
It should be noted that, the raw material that Chinese medicinal herbs decoction of the present invention adopts in preparation process has following source: Herba Houttuyniae selects the dry aerial parts of saururaceae plant houttuynia cordata Houttuynia cordata Thunb..Folium Mori select the dried leaves of moraceae plants Mulberry Morus alba L..Folium firmianae selects the dried leaves of Sterculiaceae plant Firmiana platanifolia (Linn. f.) Marsili Firmiana plantanifolia (L.f.) Marsili.Pericarpium Citri grandis selects the dry peel of Citrus paradisi Macfadyen Citrus grandis (L.) Osbecd.Caulis Cucurbitae selects the dry stem of cucurbitaceous plant Fructus Cucurbitae moschatae Cucurbitamoschata (Duch.Ex Lam.) Duch.Ex Poir..Rhizoma Phragmitis selects the dry rhizome of grass phragmites communis Phragmites communis Trin..
By the preparation method that above-mentioned each Chinese crude drug is prepared into enema be: (1) takes Herba Houttuyniae 50-63 part, Folium Mori 27-35 part, Folium firmianae 30-39 part, Pericarpium Citri grandis 12-18 part, Caulis Cucurbitae 15-30 part and Rhizoma Phragmitis 15-30 part, clean roguing, dry, powder mixes, and is broken into granule; (2) above-mentioned graininess medical material is added water cover powder 2cm again, soak 1-1.2h, pull medical material out and put during multi-functional extractions is filled with and decoct with water secondary, the water of first time totalling medical material 8-12 times amount, decoct 2h, get decocting liquid, filter, second time adds up the water of medical material 6-10 times amount, decoct 2h, get twice decocting liquid to merge, filter, the concentrated solution that when being concentrated into 90 DEG C, relative density (comparing water) is 1.10-1.15; (3) concentrated solution is set to 0-5 DEG C of deepfreeze 24h, cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate reconcentration containing 0.5-1.0g crude drug amount, obtains Chinese medicinal herbs decoction to every milliliter.
When enema of the present invention is used for the treatment of ulcerative colitis, first advise patient voluntarily emptying two just, deeply breathe, whole body loosens, and to improve successful intubation, palliates the agonizing sufferings.Suitable coloclysis position is taked, as pathological changes takes left lateral position rectum, sigmoid colon, descending colon person according to diseased region shown in intestinal mirror; Pathological changes takes right arm reclining transverse colon, ascending colon person.Coloclysis strictly need be grasped liquid dose, temperature, pressure altitude, drip speed.Enema temperature is advisable with 39 DEG C-41 DEG C, and the too high intestinal mucosa that easily causes of temperature is scalded, too low, to making enterospasm, increases the weight of stomachache.Coloclysis adopts Rectolysis, and by paraffin oil sufficient lubrication catheter proximal end and anal orifice, helically formula inserts anus.Note warming during intubate, too much do not expose patient, initiatively link up with patient, dispersion patient attention, alleviates sense of discomfort.Correctly intubation length is grasped according to patient's diseased region.Medicinal liquid drips speed, drips be advisable with 50-60 per minute, and liquid level is no more than 3Ocm apart from anus.After advising patient to keep knee chest position 20-30min after coloclysis, then the 1h that reposes, then movable gradually.
The present invention is prepared into enema by being boiled medicine by the formula of screening, pass through herbal retention enema, medicine is without stomach and small intestinal, avoid the impact on medicine such as gastric acid, digestive enzyme, medicine can be absorbed by colonic mucosa, directly acts on focus, can significantly improve the therapeutic efficiency of ulcerative colitis, and find without obvious adverse reaction, low cost.
Detailed description of the invention
Be below specific embodiments of the invention, technical scheme of the present invention is done to describing further, but protection scope of the present invention be not limited to these embodiments.Every do not deviate from the present invention's design change or equivalent substituting include within protection scope of the present invention.
Embodiment 1
Crude drug prescription: Herba Houttuyniae 5.6kg, Folium Mori 3.0kg, Folium firmianae 3.4kg, Pericarpium Citri grandis 1.5kg, Caulis Cucurbitae 2.2kg, Rhizoma Phragmitis 2.2kg.
Preparation technology: (1) takes the above-mentioned Chinese crude drug of recipe quantity, cleans roguing, dries, and mixing, is ground into granule; (2) above-mentioned graininess medical material is added water cover powder 2cm again, soak 1h, pull medical material out and put during multi-functional extractions is filled with and decoct with water secondary, first time totalling medical material 10 times amount water, decoct 2h, get decocting liquid, filter, second time adds up the water of medical material 8 times amount, decoct 2h, get twice decocting liquid to merge, filter, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.10; (3) concentrated solution is put 4 DEG C of deepfreeze 24h, cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate reconcentration containing 0.9g crude drug amount, obtains enema to every milliliter.
Embodiment 2
Crude drug prescription: Herba Houttuyniae 5.8kg, Folium Mori 2.7kg, Folium firmianae 3.0kg, Pericarpium Citri grandis 1.8kg, Caulis Cucurbitae 2.4kg, Rhizoma Phragmitis 2.0kg.
Preparation technology: (1) takes the above-mentioned Chinese crude drug of recipe quantity, cleans roguing, dries, and mixing, is ground into granule; (2) above-mentioned graininess medical material is added water cover powder 2cm again, soak 1h, pull medical material out and put during multi-functional extractions is filled with and decoct with water secondary, first time totalling medical material 12 times amount water, decoct 2h, get decocting liquid, filter, second time adds up the water of medical material 10 times amount, decoct 2h, get twice decocting liquid to merge, filter, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.10; (3) concentrated solution is put 2 DEG C of deepfreeze 24h, cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate reconcentration containing 0.9g crude drug amount, obtains enema to every milliliter.
Embodiment 3
Crude drug prescription: Herba Houttuyniae 5.0kg, Folium Mori 3.2kg, Folium firmianae 3.5kg, Pericarpium Citri grandis 1.5kg, Caulis Cucurbitae 1.5kg, Rhizoma Phragmitis 3.0kg.
Preparation technology: (1) takes the above-mentioned Chinese crude drug of recipe quantity, cleans roguing, dries, and mixing, is ground into granule; (2) above-mentioned graininess medical material is added water cover powder 2cm again, soak 1h, pull medical material out and put during multi-functional extractions is filled with and decoct with water secondary, first time totalling medical material 10 times amount water, decoct 2h, get decocting liquid, filter, second time adds up the water of medical material 10 times amount, decoct 2h, get twice decocting liquid to merge, filter, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.15; (3) concentrated solution is put 5 DEG C of deepfreeze 24h, cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate reconcentration containing 1.0g crude drug amount, obtains enema to every milliliter.Clinical practice example
Through patients of ulcerative colitis 82 example that intestinal mirror and pathologic finding are made a definite diagnosis, all patients are divided into test group and each 41 examples of matched group at random.In test group, man 23 example, female 18 example; Age 43-63 year; Course of disease 2-4 person 24 example, 0-2 person 17 example.In matched group, man 22 example, female 19 example; 41-62 years old ages; Course of disease 2-4 person 25 example, 0-2 person 16 example.The no significant difference such as two groups of sexes, age, courses of disease, have comparability.
Matched group adopts salazosulfamide pyrimidine 4g, and montmorillonite powder 3g, adds normal saline 200mL, once a day retention enema.The enema that test group adopts the embodiment of the present invention 1 to prepare is about 200mL and carries out retention-enema treatment.Advise patient before coloclysis voluntarily emptying two just, deeply breathe, whole body loosens, and to improve successful intubation, palliates the agonizing sufferings.Suitable coloclysis position is taked, as pathological changes takes left lateral position rectum, sigmoid colon, descending colon person according to diseased region shown in intestinal mirror; Pathological changes takes right arm reclining transverse colon, ascending colon person.Coloclysis strictly need be grasped liquid dose, temperature, pressure altitude, drip speed.Enema temperature is advisable with 39 DEG C-41 DEG C, and the too high intestinal mucosa that easily causes of temperature is scalded, too low, to making enterospasm, increases the weight of stomachache.Coloclysis adopts Rectolysis, and by paraffin oil sufficient lubrication catheter proximal end and anal orifice, helically formula inserts anus.Note warming during intubate, too much do not expose patient, initiatively link up with patient, dispersion patient attention, alleviates sense of discomfort.Correctly intubation length is grasped according to patient's diseased region.Medicinal liquid drips speed, drips be advisable with 50-60 per minute, and liquid level is no more than 3Ocm apart from anus.After advising patient to keep knee chest position 20-30min after coloclysis, then the 1h that reposes, then movable gradually.
Two groups of retention enemas 1 time all every night, 15d is 1 course for the treatment of, per course for the treatment of interval 5d.All treat 2 post-evaluation course for the treatment of curative effects for two groups.Criterion of therapeutical effect is drafted as follows with reference to " ulcerative colitis diagnostic criteria and the standard of curative effect evaluation ": complete incidence graph is clinical symptom disappearance, and colonoscope check mucosa is roughly normal; Effectively substantially disappear for clinical symptoms, mucosa mild inflammation is shown in colonoscope check; Invalid is that clinical symptoms, scope and pathologic finding are without improvement.
Result of the test according to table 1 can be found out, matched group total effective rate 61.0%, and test group total effective rate is 87.8%, and the evident in efficacy of obvious test group is better than matched group, and this illustrates that the curative effect of Chinese medicinal herbs decoction of the present invention to ulcerative colitis is better.
Table 1 liang group comparitive study (example)
Claims (5)
1. treat an enema for ulcerative colitis, it is characterized in that: described enema is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Herba Houttuyniae 50-63 part, Folium Mori 27-35 part, Folium firmianae 30-39 part, Pericarpium Citri grandis 12-18 part, Caulis Cucurbitae 15-30 part, Rhizoma Phragmitis 15-30 part.
2. the enema for the treatment of ulcerative colitis according to claim 1, is characterized in that: described is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Herba Houttuyniae 54-58 part, Folium Mori 29-32 part, Folium firmianae 33-35 part, Pericarpium Citri grandis 14-16 part, Caulis Cucurbitae 20-24 part, Rhizoma Phragmitis 20-24 part.
3. the enema for the treatment of ulcerative colitis according to claim 2, is characterized in that: described enema is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Herba Houttuyniae 56 parts, 30 parts, Folium Mori, Folium firmianae 34 parts, Pericarpium Citri grandis 15 parts, Caulis Cucurbitae 22 parts, Rhizoma Phragmitis 22 parts.
4. the application of the traditional Chinese medicinal material raw materials compositions described in any one of claim 1-3 in the external used medicine of preparation treatment ulcerative colitis.
5. application according to claim 4, is characterized in that, described external used medicine is enema.
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| CN201510226410.2A CN104857329A (en) | 2015-05-06 | 2015-05-06 | Clysis liquid for curing ulcerative colitis |
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| CN201510226410.2A CN104857329A (en) | 2015-05-06 | 2015-05-06 | Clysis liquid for curing ulcerative colitis |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023186181A1 (en) * | 2022-04-01 | 2023-10-05 | 北京五和博澳药业股份有限公司 | Application of mulberry extract in preparation of drug for treating ulcerative colitis |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101450204A (en) * | 2008-12-19 | 2009-06-10 | 段兴 | Medicine for treating intestinal catarrh and preparation method thereof |
| CN102727758A (en) * | 2012-06-29 | 2012-10-17 | 李云萍 | Traditional Chinese medicine enema for treating ulcerative colitis |
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- 2015-05-06 CN CN201510226410.2A patent/CN104857329A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101450204A (en) * | 2008-12-19 | 2009-06-10 | 段兴 | Medicine for treating intestinal catarrh and preparation method thereof |
| CN102727758A (en) * | 2012-06-29 | 2012-10-17 | 李云萍 | Traditional Chinese medicine enema for treating ulcerative colitis |
Non-Patent Citations (3)
| Title |
|---|
| 张前德主编: "《慢性病中医临床特色与优势》", 31 July 2013, 江苏科学技术出版社 * |
| 江学良等: "鱼腥草对溃疡性结肠炎患者直肠肛门动力学的影响", 《中医药学报》 * |
| 江学良等: "鱼腥草治疗初发型溃疡性结肠炎的临床研究", 《世界华人消化杂志》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023186181A1 (en) * | 2022-04-01 | 2023-10-05 | 北京五和博澳药业股份有限公司 | Application of mulberry extract in preparation of drug for treating ulcerative colitis |
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Application publication date: 20150826 |