CN105148024A - Zhichuangling ointment and production technology - Google Patents
Zhichuangling ointment and production technology Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine ointment for treating hemorrhoids, and particularly discloses a Zhichuangling ointment capable of radically treating internal hemorrhoids, external hemorrhoid and mixed hemorrhoids and a production technology. The Zhichuangling ointment comprises the following raw medicinal materials in parts by weight: 0.15-0.35 part of calculus bovis, 0.03-0.1 part of musk, 0.1-0.3 part of pearl, 0.15-0.3 part of borneol, 3-10 parts of mastic, 3-10 parts of myrrh, 3-10 parts of panax notoginseng, 3-10 parts of rhizoma bletillae, 6-15 parts of honeysuckle and 9-15 parts of folium isatidis. The Zhichuangling ointment is exact in curative effect on treating internal hemorrhoids, external hemorrhoid and mixed hemorrhoids, clear in action mechanism and free of toxic and side effects and adverse reaction, and has a multiple-target curative effect on clinically treating hemorrhoids: I, targeting the basic reason: killing hemorrhoids virus, and preventing rectum and anus from being infected with virus; II, quickly relieving symptoms of patients suffering from hemorrhoids, such as hemafecia, haemorrhoids prolapsed, pain, pruritus, anus swelling, rectal mucosa hyperemia and anabrosis; III, promoting blood circulation to remove blood stasis, dredging meridians, clearing heat, removing toxicity, reducing swelling and resolving mass; IV, preventing complication caused by rectal cancer.
Description
Technical field
The present invention is a kind of traditional Chinese herb medicine for the treatment of hemorrhoid, particularly a kind of chemicals curing piles ointment machin processing technology can effecting a radical cure internal hemorrhoid, external hemorrhoid, mixed hemorrhoid.
Background technology
Hemorrhoid are a kind of commonly encountered diseases, frequently-occurring disease, high morbidity, and easy concurrent rectal cancer, and its serious threat common people are healthy.Studying carefully its this cause, is that coming off becomes hemorrhoid to make " anus pad " because anal infection virus is imported into " anus pad ".Described " anus pad ", refers to tissue rectum and anal canal mucosa having blood vessel, and the blood vessel of " anus pad " the inside is called " hemorrhoidal vessels ", and the function of " anus pad " coordinates defecation of human body and controls defecation." anus pad " has elasticity, and it can protect perianal muscle, not easily dried stool infringement, can also protect the intact closed of anus simultaneously, perianal be cleaned intact.When " anus pad " has infected virus, will cause " anus pad " organizational slack, there is varicose prolapsus in " hemorrhoidal vessels ", piles just there occurs.Obtained piles must take medicine, Western medicine is as pacified continue blood, vitamin K throughout the year; Chinese medicine is as YUNNAN BAIYAO, Folium Nelumbinis ball.Said medicine can only relief of symptoms, temporarily palliates the agonizing sufferings, can not cure.As hemorrhoid patients occur that pain cannot be stood time, need to perform an operation treatment, Post operation easily produces slack anus, fecal incontinence, causes very large psychic pain to patient.
At present, there is no radical cure internal hemorrhoid, external hemorrhoid, the Chinese medicine of mixed hemorrhoid and Western medicine both at home and abroad.
Summary of the invention
The object of the invention is can not effect a radical cure to overcome existing piles medicine the defect that hemorrhoid and operative treatment cause slack anus, inventing a kind of determined curative effect, clear mechanism, the chemicals curing piles ointment machin processing technology with radical cure function that has no side effect, have no adverse reaction.
The object of the invention is to realize as follows:
Described chemicals curing piles ointment, is made up of following crude drug: Calculus Bovis, Moschus, Margarita, Borneolum Syntheticum, Olibanum, Myrrha, Radix Notoginseng, Pseudobulbus Bletillae (Rhizoma Bletillae), Flos Lonicerae, Folium Isatidis, and its weight portion scope is respectively:
Described chemicals curing piles ointment, preferred weight part of its crude drug is: Calculus Bovis 0.2, Moschus 0.06, Margarita 0.2, Borneolum Syntheticum 0.2, Olibanum 8, Myrrha 8, Radix Notoginseng 9, Pseudobulbus Bletillae (Rhizoma Bletillae) 6, Flos Lonicerae 15, Folium Isatidis 15.
The processing technology of described chemicals curing piles ointment, comprises the following steps:
Step one: Calculus Bovis, Moschus, Margarita, the super pulverizer of Borneolum Syntheticum are pulverized, crosses 300 mesh sieves, becomes the cell grade micropowder that particle diameter is less than 48um, and loaded in vial, put into calorstat for subsequent use;
Step 2: crude drug Olibanum, Myrrha, Radix Notoginseng, Pseudobulbus Bletillae (Rhizoma Bletillae), Flos Lonicerae, Folium Isatidis Six-element Chinese medicine is pulverized with pulverizer respectively, cross 150 mesh sieves, make fine powder, above-mentioned fine powder is pulverized with super pulverizer respectively, cross 300 mesh sieves, become the cell grade micropowder that particle diameter is less than 48um, by the Olibanum obtained, Myrrha, Radix Notoginseng, Pseudobulbus Bletillae (Rhizoma Bletillae), Flos Lonicerae, it be the percent concentration of own wt 10 times is in the ethanol of 95% that the cell grade micropowder of Folium Isatidis adds respectively, take disposable reflux, extract, active ingredient, extract two hours, filter the medicinal liquid and the medicinal residues that obtain above-mentioned Six-element crude drug,
Step 3: by each for gained in step 2 crude drug medicinal liquid, with multi-functional extraction concentration and recovery unit, makes one-level clear paste by each concentration of liquid medicine, puts into calorstat for subsequent use;
Step 4: by each for gained in step 2 raw material medicinal residues, decoct twice respectively, add is the water of own wt six times at every turn, each decoction one hour, merge twice decoction liquor respectively, by multi-functional extraction concentration and recovery unit filtering and concentrating, make the secondary clear paste of each crude drug, put into calorstat for subsequent use;
Step 5: the one-level clear paste of each crude drug obtained in step 3 and step 4 and secondary clear paste are mixed; add the cell grade micropowder be made up of Calculus Bovis, Moschus, Margarita, Borneolum Syntheticum that step one obtains again; and stir; then pour in bottle with automatic filling machine, namely make described chemicals curing piles ointment.
Good effect of the present invention is as follows: treat internal hemorrhoid, external hemorrhoid, mixed hemorrhoid clinically, determined curative effect, clear mechanism, have no side effect, have no adverse reaction.The present invention treats hemorrhoid clinically and has Mutiple Targets curative effect: one kills hemorrhoid virus, prevents rectum, anal infection virus is its this cause; Two rapid recovery hemorrhoid patients are had blood in stool, blood stasis prolapsus, pain, pruritus, anus swelling, mucous membrane of rectum hyperemia, ulcer etc.; Three blood circulation promoting and blood stasis dispelling, dredging the meridian, heat-clearing and toxic substances removing, dispersing swelling and dissipating binds; Four prevent rectal cancer complication.
Detailed description of the invention
Below preferred embodiment of the present invention is described in detail:
Embodiment 1:
Each crude drug is taken: Calculus Bovis 0.2g, Moschus 0.06g, Margarita 0.2g, Borneolum Syntheticum 0.2g, Olibanum 8g, Myrrha 8g, Radix Notoginseng 9g, Pseudobulbus Bletillae (Rhizoma Bletillae) 6g, Flos Lonicerae 15g, Folium Isatidis 15g by following weight.
Embodiment 2:
Each crude drug is taken: Calculus Bovis 0.3g, Moschus 0.08g, Margarita 0.3g, Borneolum Syntheticum 0.3g, Olibanum 10g, Myrrha 10g, Radix Notoginseng 10g, Pseudobulbus Bletillae (Rhizoma Bletillae) 8g, Flos Lonicerae 15g, Folium Isatidis 15g by following weight.
Embodiment 3:
Each crude drug is taken: Calculus Bovis 0.15g, Moschus 0.04g, Margarita 0.1g, Borneolum Syntheticum 0.1g, Olibanum 6g, Myrrha 6g, Radix Notoginseng 7g, Pseudobulbus Bletillae (Rhizoma Bletillae) 5g, Flos Lonicerae 12g, Folium Isatidis 12g by following weight.
The processing technology of above three embodiments is as follows:
Step one: Calculus Bovis, Moschus, Margarita, the super pulverizer of Borneolum Syntheticum are pulverized, crosses 300 mesh sieves, becomes the cell grade micropowder that particle diameter is less than 48um, and loaded in vial, put into calorstat for subsequent use;
Step 2: crude drug Olibanum, Myrrha, Radix Notoginseng, Pseudobulbus Bletillae (Rhizoma Bletillae), Flos Lonicerae, Folium Isatidis Six-element Chinese medicine is pulverized with pulverizer respectively, cross 150 mesh sieves, make fine powder, above-mentioned fine powder is pulverized with super pulverizer respectively, cross 300 mesh sieves, become the cell grade micropowder that particle diameter is less than 48um, by the Olibanum obtained, Myrrha, Radix Notoginseng, Pseudobulbus Bletillae (Rhizoma Bletillae), Flos Lonicerae, it be the percent concentration of own wt 10 times is in the ethanol of 95% that the cell grade micropowder of Folium Isatidis adds respectively, take disposable reflux, extract, active ingredient, extract two hours, filter the medicinal liquid and the medicinal residues that obtain above-mentioned Six-element crude drug,
Step 3: by each for gained in step 2 crude drug medicinal liquid, with multi-functional extraction concentration and recovery unit, makes one-level clear paste by each concentration of liquid medicine, puts into calorstat for subsequent use;
Step 4: by each for gained in step 2 raw material medicinal residues, decoct twice respectively, add is the water of own wt six times at every turn, each decoction one hour, merge twice decoction liquor respectively, by multi-functional extraction concentration and recovery unit filtering and concentrating, make the secondary clear paste of each crude drug, put into calorstat for subsequent use;
Step 5: the one-level clear paste of each crude drug obtained in step 3 and step 4 and secondary clear paste are mixed; add the cell grade micropowder be made up of Calculus Bovis, Moschus, Margarita, Borneolum Syntheticum that step one obtains again; and stir; then pour in bottle with automatic filling machine, namely make described chemicals curing piles ointment.
Clinical diagnosis is reported:
1. diagnostic criteria:
1-1 diagnosed SARS case inclusive criteria:
According to the clinical diagnosis of " hemorrhoid efficacy assessment standard ", on case diagnosis is selected, the symptom including case in is mainly: internal pile hematochezia, and blood stasis prolapses, and mucous membrane of rectum is congested, ulcer, and anus is uncomfortable; External hemorrhoid rectal tenesmus, pain, pruritus, there is foreign body sensation; Mixed hemorrhoid also has the dual symptom of internal hemorrhoid, external hemorrhoid.
1-2 differentiation of tcm inclusive criteria:
According to the clinical diagnosis of differentiation of tcm, on case diagnosis is selected, the symptom including case in is mainly: the generation of internal hemorrhoid, mainly because anomalous vein wall is weak, eating and drinking without temperance, causes production of dryness-heat in the interior, tenesmus large intestine, constipation is obstructed, sludging, warm blood is fought mutually, and QI and blood is in length and breadth, muscle arteries and veins interlocks, and ties and stagnantly not to fall apart; External hemorrhoid, mainly due to fissure in ano, prolapses repeatedly, and evil poison is outer invades, damp invasion of lower energizer, and cause blood operation not smooth, muscle arteries and veins blocks, and the knot that becomes silted up does not fall apart, and with the passing of time becomes skin tag; Mixed hemorrhoid has internal hemorrhoid, the dual symptom of external hemorrhoid concurrently.
2. case selection
In selection of clinical internal hemorrhoid, external hemorrhoid, mixed hemorrhoid patient 120 example, be divided into treatment group and matched group at random.Treatment group 60 example, man 53 example, female 7 example, age 26-65 year, 40 years old mean age, course of disease 1-18, average course of disease 6.2 years.Include case in and all belong to internal hemorrhoid, external hemorrhoid, mixed hemorrhoid patient.Matched group 60 example, man 54 example, female 6 example, age 26-65 year, 40.5 years old mean age, course of disease 1-18, average course of disease 6.1 years, includes case in and all belongs to internal hemorrhoid, external hemorrhoid, mixed hemorrhoid patient.Two groups of cases all belong to internal hemorrhoid, external hemorrhoid, mixed hemorrhoid patient, and two groups of cases through statistical disposition in sex, age, the course of disease, symptom etc., without significant difference (P < 0.005), have comparability, have statistical significance.
3. administrated method
Clinical treatment: the chemicals curing piles ointment for the treatment of group prepared by the embodiment of the present invention 1, once a day, each 2g, is coated in outside anal dosage before sleeping evening.Matched group is for oral administration, outer painting composition of medicine: pile eliminating tablet for oral administration (Hainan Hai Li pharmaceutical Co. Ltd produces, lot number Z20093045) dosage every day 3 times, each 6; Outer painting ZHICHUANG GAO (Yunnan Paiyao Group Corp., Ltd, lot number Z2006003) dosage every day 2 times, each 1.5g.Two groups of courses for the treatment of are 15 days.
4. observation index:
Clinical observation: two groups are had blood in stool at treatment phase every day entry, swell and ache, prolapse, suppurate, constipation, secretions, blood stasis deviate from, and two groups are 15 days and do an anoscopy efficacy result.
5. criterion of therapeutical effect:
Clinical efficacy is evaluated: evaluate two groups of therapeutic effect according to " hemorrhoid efficacy assessment standard ".(1) symptom efficacy assessment standard: effective: have blood in stool, swell and ache, prolapse, suppurate, constipation, secretions, blood stasis are deviate from etc., and symptom all disappears; Effective: to have blood in stool, swell and ache, prolapse, suppurate, constipation, secretions, blood stasis are deviate from etc., and paresthesia epilepsy number of times, degree and persistent period obviously reduce or substantially disappear; Invalid: internal hemorrhoid, external hemorrhoid, mixed hemorrhoid symptom are without change or every exacerbation of symptoms.(2) anoscope efficacy assessment standard: effective: anal polyp, prolapsus, mucous membrane of rectum hyperemia, ulcer, the symptom such as to swell and ache all disappear, and hemorrhoid are cured; Effective: anal polyp, prolapsus, mucous membrane of rectum hyperemia, ulcer, paresthesia epilepsy number of times, degree and the persistent period such as to swell and ache obviously reduce or substantially disappear; Invalid: internal hemorrhoid, external hemorrhoid, mixed hemorrhoid symptom are without change or every exacerbation of symptoms.
6. therapeutic outcome:
6-1 two groups of clinical symptoms therapeutic outcomes compare: the results are shown in Table 1.There is highly significant difference (P < 0.001) in treatment group and matched group total effective rate, treatment group is better than matched group.
Table 1 treatment group and the clinical hemorrhoid symptom comparitive study of matched group
Treatment group and matched group (P < 0.001)
6-2 two groups of anoscope curative effect display degrees compare: the results are shown in Table 2.
There is highly significant difference (P < 0.001) treatment group and be better than matched group in treatment group and matched group total effective rate.
Table 2 treatment group and matched group clinical hemorrhoid anoscope comparitive study
Treatment group and matched group (P < 0.001)
Above-mentioned internal hemorrhoid, external hemorrhoid, mixed hemorrhoid patient clinical symptom comparitive study, treatment group total effective rate is 100%, and matched group is that 45%, two groups of total effective rates exist highly significant difference (P < 0.001), and treatment group is better than matched group; Clinical anoscope comparitive study, treatment group total effective rate is 100%, and matched group is 41.7%.There is highly significant difference (P < 0.001) in two groups of total effective rates, treatment group is better than matched group.
Clinical case:
Case 1: what accounts for skilful doctor's case: man, 43 years old, civil servant, trouble hemorrhoid 8 years, on May 12nd, 2012 goes to a doctor.Patient's readme: fecal blood, hurt like hell, anus swelling, the swollen thing prolapsus of stool; Enteroscopy, mucous membrane of rectum is congested, and anus has polyp, ulcer, has tumor, invalid to the hospitalize of too much family, and hospital suggestion patient performs an operation treatment, and patient does not agree to.Rear patient is through with " chemicals curing piles ointment " of the present invention, and anal external medicine is after one week, and the symptom such as patient's fecal blood, hurt like hell, anus swelling, the swollen thing prolapsus of stool disappears substantially.Medication is after two weeks, and the symptom such as patient's fecal blood, pain, anus swelling, the swollen thing prolapsus of stool all disappears.Patient does anoscopy, and the symptoms such as mucous membrane of rectum hyperemia, anal polyp, ulcer, tumor all disappear.Mixed hemorrhoid disease cured.Follow up a case by regular visits to after 2 years and do not recur.
Case 2: Zhou Shitong case: man, 66 years old, peasant, trouble hemorrhoid 3 years, on June 16th, 2012 goes to a doctor.Patient's readme: anal have lump, fecal blood, every day hurt like hell, invalid to the hospitalize of too much family.Anoscopy anal has polyp, has ulcer, has lump, and hospital diagnosis is mixed hemorrhoid.Take multiple Western medicine, the multiple coating of external is all invalid.Patient is through with chemicals curing piles ointment of the present invention, and anal external medicine is after one week, and the symptoms such as patient's anal lump, stool hyperemia, pain disappear substantially.Medication is after two weeks, and the symptoms such as patient's anus lump, stool hyperemia, pain all disappear, and patient does anoscopy, and the symptoms such as anal polyp, ulcer, lump all disappear.Mixed hemorrhoids disease is cured.Follow up a case by regular visits to after 2 years and do not recur.
The flourish case of case 3: Wang Jin: female, 39 years old, civil servant, trouble hemorrhoid 3 years, on June 20th, 2012 goes to a doctor.Patient's readme: hospital diagnosis is mixed hemorrhoid, anus breaks, stool hyperemia, pain, have lump, rectal ulcer.Take hospital to medicine take a favorable turn, after drug withdrawal, symptom rebounds again, can not cure.Rear patient is through with " chemicals curing piles ointment " of the present invention, and anal external medicine is after one week, and the symptoms such as anus breaks, stool hyperemia, pain, lump disappear substantially.Medication is after two weeks, and patient's anus breaks, have blood in stool, pain, lump etc. are whole disappears.Patient does anoscopy, and the symptoms such as anus breaks, lump, ulcer all disappear.Mixed hemorrhoid disease cured.Follow up a case by regular visits to after 2 years and do not recur.
Case 4: Zhang Xiuhai case: man, 55 years old, boss, trouble hemorrhoid 5 years, on July 23rd, 2012 goes to a doctor.Patient's readme: proctalgia, dyschizia increase the weight of, have blood in stool, anus has lump.Anoscopy is done by hospital: anal has polyp, has ulcer, has lump, is diagnosed as mixed hemorrhoid, takes multi-medicament and does not cure.Patient is through with " chemicals curing piles ointment " of the present invention, and anal external medicine is after one week, patient's proctalgia, have blood in stool, the symptom such as lump disappears substantially.Medication is after two weeks, patient's proctalgia, have blood in stool, anus lump all disappears.Patient does anoscopy, and anal polyp, ulcer, lump all disappear, patient's mixed hemorrhoid disease cured.Follow up a case by regular visits to after 2 years and do not recur.
Case 5: Liu Peng case: man, 27 years old, peasant, trouble hemorrhoid 5 years, on August 9th, 2012 goes to a doctor.Patient's readme: fecal blood, proctalgia, pruritus ani, anus have lump.Anoscopy is done by hospital, and rectum has ulcer, has lump, mucous membrane of rectum is congested, is diagnosed as mixed hemorrhoid.Hospital is to opening multiple oral medicine and external medicine is all failed to respond to any medical treatment.Through with " chemicals curing piles ointment " of the present invention, anal external medicine is after one week, and patient has blood in stool, proctalgia, pruritus, lump disappear substantially.Medication is after two weeks, and patient defecates hyperemia, and the symptoms such as proctalgia, pruritus, lump all disappear, and patient does anoscopy, and rectal ulcer, lump, hyperemia all disappear.Mixed hemorrhoid disease cured.Follow up a case by regular visits to after 2 years and do not recur.
Case 6: Yang Chao case: man, 56 years old, civil servant, trouble hemorrhoid 4 years, on August 12nd, 2012 goes to a doctor.Patient's readme: suffer from hemorrhoid 4 years, invalid in Beijing Duo Jia hospitalize, every day hurt like hell, fecal blood, stool anus swell thing prolapsus.Anoscopy is done by patient hospital, mucous membrane of rectum hyperemia, rectal ulcer, in have tumor, be diagnosed as mixed hemorrhoid, suggestion corrective surgery treatment.Sufferers themselves and family members do not agree to, are afraid of that operation is unsuccessful, defecate malfunctioning all the life.Patient is through with " chemicals curing piles ointment " of the present invention, and anal external medicine is after one week, and patient's proctalgia, stool are congested, anus swells, and the symptoms such as thing disappear substantially.Medication is after two weeks, patient's proctalgia, have blood in stool, anus of the defecating symptoms such as thing prolapsus that swell all disappear.Patient does anoscopy, and mucous membrane of rectum hyperemia, rectal ulcer, enteral tumor etc. all disappear, patient's mixed hemorrhoid disease cured.Follow up a case by regular visits to after 2 years and do not recur.
Above-mentioned case patient, course of disease year is of a specified duration, have internal hemorrhoid, external hemorrhoid, mixed hemorrhoid concurrently, rectum, anal function lacked of proper care, disease opinion is had blood in stool, blood stasis prolapsus, pain, pruritus, anus swelling, mucous membrane of rectum hyperemia, ulcer etc.Treatment should focus on the principal cause of a disease, the present invention treats hemorrhoid clinically and has Mutiple Targets curative effect: one kills hemorrhoid virus, prevents rectum, anal infection virus is its this cause; Two rapid recovery hemorrhoid patients are had blood in stool, blood stasis prolapsus, pain, pruritus, anus swelling, mucous membrane of rectum hyperemia, ulcer etc.; Three blood circulation promoting and blood stasis dispelling, dredging the meridian, heat-clearing and toxic substances removing, dispersing swelling and dissipating binds; Four prevent rectal cancer arch-criminal complication.Patient's anal by being coated with chemicals curing piles ointment of the present invention, obtains radical cure curative effect outward.Follow up a case by regular visits to after 2 years and all do not recur.
Claims (3)
1. chemicals curing piles ointment is characterized in that: it is made up of following crude drug: Calculus Bovis, Moschus, Margarita, Borneolum Syntheticum, Olibanum, Myrrha, Radix Notoginseng, Pseudobulbus Bletillae (Rhizoma Bletillae), Flos Lonicerae, a Folium Isatidis, and its weight portion scope is respectively:
2. chemicals curing piles ointment according to claim 1, is characterized in that: preferred weight part of its crude drug is: Calculus Bovis 0.2, Moschus 0.06, Margarita 0.2, Borneolum Syntheticum 0.2, Olibanum 8, Myrrha 8, Radix Notoginseng 9, Pseudobulbus Bletillae (Rhizoma Bletillae) 6, Flos Lonicerae 15, Folium Isatidis 15.
3. the processing technology of chemicals curing piles ointment according to claim 1, is characterized in that:
The processing technology of described chemicals curing piles ointment, comprises the following steps:
Step one: Calculus Bovis, Moschus, Margarita, the super pulverizer of Borneolum Syntheticum are pulverized, crosses 300 mesh sieves, becomes the cell grade micropowder that particle diameter is less than 48um, and loaded in vial, put into calorstat for subsequent use;
Step 2: crude drug Olibanum, Myrrha, Radix Notoginseng, Pseudobulbus Bletillae (Rhizoma Bletillae), Flos Lonicerae, Folium Isatidis Six-element Chinese medicine is pulverized with pulverizer respectively, cross 150 mesh sieves, make fine powder, above-mentioned fine powder is pulverized with super pulverizer respectively, cross 300 mesh sieves, become the cell grade micropowder that particle diameter is less than 48um, by the Olibanum obtained, Myrrha, Radix Notoginseng, Pseudobulbus Bletillae (Rhizoma Bletillae), Flos Lonicerae, it be the percent concentration of own wt 10 times is in the ethanol of 95% that the cell grade micropowder of Folium Isatidis adds respectively, take disposable reflux, extract, active ingredient, extract two hours, filter the medicinal liquid and the medicinal residues that obtain above-mentioned Six-element crude drug,
Step 3: by each for gained in step 2 crude drug medicinal liquid, with multi-functional extraction concentration and recovery unit, makes one-level clear paste by each concentration of liquid medicine, puts into calorstat for subsequent use;
Step 4: by each for gained in step 2 raw material medicinal residues, decoct twice respectively, add is the water of own wt six times at every turn, each decoction one hour, merge twice decoction liquor respectively, by multi-functional extraction concentration and recovery unit filtering and concentrating, make the secondary clear paste of each crude drug, put into calorstat for subsequent use;
Step 5: the one-level clear paste of each crude drug obtained in step 3 and step 4 and secondary clear paste are mixed; add the cell grade micropowder be made up of Calculus Bovis, Moschus, Margarita, Borneolum Syntheticum that step one obtains again; and stir; then pour in bottle with automatic filling machine, namely make described chemicals curing piles ointment.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110755548A (en) * | 2019-12-04 | 2020-02-07 | 张友弼 | Formula and preparation method of hemorrhoid ointment |
| CN111298053A (en) * | 2018-11-25 | 2020-06-19 | 佳木斯烧伤专科医院 | Bezoar dragon bone ointment for treating hemorrhoid |
| CN114903946A (en) * | 2022-04-14 | 2022-08-16 | 克珠 | Tibetan medicine composition for treating various hemorrhoids and application thereof |
| CN115154529A (en) * | 2022-07-16 | 2022-10-11 | 大有药业扬州有限公司 | External lotion for preventing and treating hemorrhoids |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1765415A (en) * | 2004-10-29 | 2006-05-03 | 金定国 | Piles ointment and its preparation method |
| CN1903289A (en) * | 2006-08-08 | 2007-01-31 | 武汉马应龙药业集团股份有限公司 | Gel for treating hemorrhoidal anus and rectum diseases, and its prepn. method |
| CN101244204A (en) * | 2008-02-02 | 2008-08-20 | 温先敏 | Suppository for treating hemorrhoid |
| CN101455745A (en) * | 2008-12-30 | 2009-06-17 | 陈永泰 | Medicine composition for treating hemorrhoids and preparation method thereof |
| CN101757449A (en) * | 2010-03-02 | 2010-06-30 | 温先敏 | Ointment preparation for treating hemorrhoid |
-
2015
- 2015-10-09 CN CN201510646401.9A patent/CN105148024B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1765415A (en) * | 2004-10-29 | 2006-05-03 | 金定国 | Piles ointment and its preparation method |
| CN1903289A (en) * | 2006-08-08 | 2007-01-31 | 武汉马应龙药业集团股份有限公司 | Gel for treating hemorrhoidal anus and rectum diseases, and its prepn. method |
| CN101244204A (en) * | 2008-02-02 | 2008-08-20 | 温先敏 | Suppository for treating hemorrhoid |
| CN101455745A (en) * | 2008-12-30 | 2009-06-17 | 陈永泰 | Medicine composition for treating hemorrhoids and preparation method thereof |
| CN101757449A (en) * | 2010-03-02 | 2010-06-30 | 温先敏 | Ointment preparation for treating hemorrhoid |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111298053A (en) * | 2018-11-25 | 2020-06-19 | 佳木斯烧伤专科医院 | Bezoar dragon bone ointment for treating hemorrhoid |
| CN110755548A (en) * | 2019-12-04 | 2020-02-07 | 张友弼 | Formula and preparation method of hemorrhoid ointment |
| CN114903946A (en) * | 2022-04-14 | 2022-08-16 | 克珠 | Tibetan medicine composition for treating various hemorrhoids and application thereof |
| CN115154529A (en) * | 2022-07-16 | 2022-10-11 | 大有药业扬州有限公司 | External lotion for preventing and treating hemorrhoids |
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| CN105148024B (en) | 2018-11-13 |
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