CN101623425B

CN101623425B - Clyster liquid for treating radioactive enteritis

Info

Publication number: CN101623425B
Application number: CN2008101376844A
Authority: CN
Inventors: 张俊华
Original assignee: Individual
Current assignee: Individual
Priority date: 2008-07-10
Filing date: 2008-07-10
Publication date: 2011-11-16
Anticipated expiration: 2028-07-10
Also published as: CN101623425A

Abstract

The invention discloses clyster liquid for treating radioactive enteritis, which is characterized by comprising the following components according to the mixture ratio: 15g of radix arnebiae seu lithospermi, 20g of agrimony, 30g of oldenlandia diffusa, 30g of dandelion, 15g of honeysuckle flower, 15g of rhubarb, 30g of purslane, 20g of garden burnet and 15g of smilax glabra rhizoma, wherein the components can fluctuate up and down by 10-20%. By medicine experiments and clinical test, the clyster liquid has a stronger bacteriostatic action for staphyiococcus aureus, colibacillus, pseudomonas pyocyanea, bacillus dysenteriae, typhoid bacillus and the like, contains various vitamins and trace elements, also can reinforce the adrenocortical function and has the functions of relieving the pain, tranquilizing the mind and inducing sleep, so that the prescription has better functions of resisting inflammation, lessening virulence of any pathogenic organism, resisting tumours, penetrating humidity, immunizing, cooling blood, relieving the stasis of blood and the like. The clyster liquid can be decocted by the hospital instead of a patient, is temporarily heated when being applied and is convenient for treating the patient.

Description

A kind of enema of radiotherapy enteritis

Technical field

The present invention relates to a kind of Chinese medicine preparation, especially relate to a kind of enema of radiotherapy enteritis.

Background technology

Radiation enteritis is meant the caused intestinal complication of malignant tumor behind radiotherapy pelvic cavity, abdominal cavity or the peritoneum, can involve small intestinal, colon and rectum respectively, so be called radioactive injury of gut again.According to clinical observation, after the pelvic cavity viscera cancer patient is accepted radiation cure, can damage colon and the symptom of similar chronic ulcerative colitis takes place; As the radiological detriment small intestinal, the symptom of similar malabsorption syndrome then can take place.Malignant tumor is accepted among the patient of radiotherapy behind pelvic cavity, abdominal cavity or peritoneum, and the incidence rate of radiation enteritis is 0.6%～17%, and average 6%.Enteritis can take place in 3/4 patient after the irradiation for cervical cancer, secondly is ovary, bladder and carcinoma of endometrium, also has fraction to be caused by prostate, testis, kidney, adrenal carcinoma and lymphoma radiotherapy.This disease sees that with the women men and women's ratio is about 1: 9 more.

Long-term observation finds that the generation of radiation enteritis is main relevant with following factors: (1) exposure dose, time: with the radiotherapy of pelvic cavity district is example, and when being lower than 4200～4500rads as 4～4.5 all irradiation doses, the sickness rate of gastrointestinal tract infringement is very low; But as 4.5～6 weeks are interior to 4500～6000rads, and sickness rate progressively rises; As strengthening exposure dose again, sickness rate increases sharply.General estimation, when 5 all internal radiation amounts surpassed 5000rads, sickness rate was about 8%.(2) intestinal of different parts is to the sensitivity difference of irradiation, its toleration: rectum＞small intestinal, colon＞stomach.(3) mobility of different parts intestinal, have or not abdominal cavity pelvic inflammation sexually transmitted disease (STD) change or history of operation and have or not vascular lesions: because terminal ileum and far-end colon are more fixing, the easily infringement of exposure.Inflammation or tissue adhesion are fixed intestinal loop, have limited the activity of intestinal segment, and the irradiation dose of this intestinal segment unit are is increased, and sickness rate increases.Behind the hysterectomy, the suffered irradiation dose of rectum is higher than not excision person.The originally existing vascular lesion of patients such as arteriosclerosis, diabetes and hypertension, the easier gastrointestinal tract that causes damages after the irradiation.(4) individual variation toleration difference: concerning most people, the toleration of irradiation is unforeseen.It is early stage that symptom can appear at treatment, finishes back or treatment back several months the course of treatment to the several years.The quality of life and the radiocurable ampere-hour that have a strong impact on tumor patient are finished.

Drug therapy mainly is antibiotic, hormone coloclysis at present, nervus presacralis sealing, a2 macroglobulin treatment on probation, hemostasis, convergence spasmolytic, topical pain relief agent and manure bate, Chinese medicine decoction oral medication.These Therapeutic Method exist significant limitation.Though in analgesia and sterilization, very big advantage is arranged, at etiological treatment, a lot of defectives is arranged.Especially to patient's intestinal wall ischemia and mucosal erosion, ulcer, the lower abdominal pain that the diarrhoea that causes, abdominal distention, poor appetite and serious symptom person occur, rectal tenesmus, stool band pus and blood symptom therapeutic effect are obvious inadequately.

And also do not have in the market for the patent medicine of pure Chinese herbs decoction enema treatment radiation enteritis.Herbal retention enema, reduced the medicine active ingredient by gastrointestinal absorption by the decomposition of liver and destruction, thereby can obtain clinical efficacy preferably.

Summary of the invention

The object of the present invention is to provide a kind of enema that is used for the treatment of radiation enteritis.

The present invention can realize by following measure:

Its composition of the present invention and proportioning are:

Radix Arnebiae (Radix Lithospermi) 15g, Herba Agrimoniae 20g, Herba Hedyotidis Diffusae 15g, Herba Taraxaci 30g, Flos Lonicerae 15g, Radix Et Rhizoma Rhei 15g, Herba Portulacae 30g, Radix Sanguisorbae 20g, Rhizoma Smilacis Glabrae 15g, above-mentioned prescription can fluctuate 10～20% according to patient.

Because the present invention adopts multiple active ingredient to make medicament, and the method direct drug injection by coloclysis, from drug study and clinical trial, staphylococcus aureus, escherichia coli, bacillus pyocyaneus, Bacillus typhi, dysentery bacterium etc. all generally had stronger bacteriostasis.Herba Hedyotidis Diffusae again can the adrenal cortex reinforcing function, and analgesia, calmness, syngignoscism are arranged.Radix Et Rhizoma Rhei has immunoregulation effect again, and contains the tannin class except that having the resisting pathogenic microbes effect.Herba Portulacae, Herba Taraxaci have abundant vitamin, trace element and mineral, strengthen patient's self immunoregulation capability, and dyspepsia, constipation are had the improvement effect.The Radix Sanguisorbae stem contains tannin, root is starch-containing is astringent hemostatic.Radix Arnebiae (Radix Lithospermi), Herba Agrimoniae have removing heat from blood, detoxifcation, rash, purge heat, lead to intestinal, removing blood stasis, the effect of stimulating the menstrual flow.We have effects such as antiinflammatory, detoxifcation, anti-tumor, eliminating dampness by diuresis, immunity and removing heat from blood, blood stasis dispelling preferably.

Herbal enema agent provided by the invention can be heated during application to 37 ℃～43 ℃ by hospital in advance for frying in shallow oil, and makes things convenient for patient.

The purposes of medicine of the present invention: be used for the treatment of intestinal wall ischemia that radiation enteritis causes and mucosal erosion, ulcer; Symptoms such as abdominal distention, stomachache, diarrhoea, rectal tenesmus, stool band pus and blood, poor appetite.

The present invention can be illustrated by following clinical trial the therapeutical effect of radiation enteritis:

Case is selected: stomachache, diarrhoea, stool band pus and blood person 180 examples, abdominal distention, poor appetite patient 100 examples appear in the abdominopelvic cavity radiation therapy patient.

Therapeutic Method: use decoction of the present invention, application process: once a day, each 100ml is heated to 37 ℃～43 ℃ retention enemas, 15 days per courses of treatment.

Therapeutic outcome:

1, stomachache, diarrhoea, stool band pus and blood patient 180 examples after treating a course of treatment, have 128 example recoveries from illness, and 38 routine symptoms obviously alleviate, and 14 routine sxs are not obvious.168 example recoveries from illness after two courses of treatment, 7 routine symptoms obviously alleviate, and 5 routine sxs are not obvious.

2, radioactivity abdominal distention, poor appetite 100 examples, 62 example recoveries from illness after treating a course of treatment, 21 routine symptoms obviously alleviate, and 17 examples alleviate not obvious.81 example recoveries from illness after two courses of treatment, 15 routine symptoms obviously alleviate, and 4 routine sxs are not obvious.

In sum, the patient that medicine of the present invention causes radiation enteritis: stomachache, diarrhoea, stool band blood, radioactivity abdominal distention, poor appetite etc. all have significant curative effect, and by statistics, total effective rate can reach more than 97.2%.

The specific embodiment

The decoction of radiotherapy enteritis of the present invention is to be formed by following formulation:

Its composition and proportioning are: Radix Arnebiae (Radix Lithospermi) 15g, Herba Agrimoniae 20g, Herba Hedyotidis Diffusae 30g, Herba Taraxaci 30g, Flos Lonicerae 15g, Radix Et Rhizoma Rhei 15g, Herba Portulacae 30g, Radix Sanguisorbae 20g, Rhizoma Smilacis Glabrae 15g.

With adding water to 400ml after the clear water immersion, decoct to 150ml, pack standby.Heat before the coloclysis to 37 ℃～43 ℃, get lateral position after advising patient's defecation, insert the about 20～30ml of anal with the two-chamber urinary catheter, take out medicinal liquid with the 50m1 syringe and inject capable retention enema from urinary catheter, once a day, totally 15 times is a course of treatment.Because of urinary catheter is thin, insert deeplyer, it is few to pour into amount of liquid medicine, and patient can be free movable, need not special posture.

This enema can be according to patient's curative effect, 2～3 courses of treatment of repeated application.

Claims

1. the enema of a radiotherapy enteritis, it is characterized in that: its composition and proportioning are: Radix Arnebiae (Radix Lithospermi) 15g, Herba Agrimoniae 20g, Herba Hedyotidis Diffusae 30g, Herba Taraxaci 30g, Flos Lonicerae 15g, Radix Et Rhizoma Rhei 15g, Herba Portulacae 30g, Radix Sanguisorbae 20g, Rhizoma Smilacis Glabrae 15g.

2. according to claim 1, a kind of enema of radiotherapy enteritis is characterized in that: described medicament is a decoction.

3. according to claim 1, the preparation method of radiotherapy enteritis enema comprises the steps:

1. above-mentioned 9 flavor Chinese medicines are added water to 400ml, decoct, filter to about 150ml, pack, seal standby;

2. be heated to 37 ℃～43 ℃ during coloclysis, urinary catheter is inserted the about 20～30ml of anal, in urinary catheter, slowly inject with 50ml syringe pump medicinal liquid.