CN103446528B - Chinese medicinal composition used for stopping pain and reducing swelling and preparation thereof - Google Patents
Chinese medicinal composition used for stopping pain and reducing swelling and preparation thereof Download PDFInfo
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Abstract
The invention relates to a Chinese medicinal composition and in particular relates to a Chinese medicinal composition used for stopping pain and reducing swelling and a preparation thereof. The Chinese medicinal composition is prepared from the following raw materials in parts by weight: 10-15 parts of crude sichuan aconite root, 10-15 parts of kusnezoff monkshood root, 10-15 parts of pericarpium zanthoxyli, 5-10 parts of gentiana macrophylla, 5-10 parts of frankincense, 5-10 parts of myrrh, 10-15 parts of radix linderae, 5-10 parts of common burreed rhizome, 5-10 parts of curcuma zedoary, 5-10 parts of peach kernel, 5-10 parts of safflower, 5-10 parts of Chinese angelica, 5-10 parts of notopterygium root, 5-10 parts of radix angelicae pubescentis, 5-10 parts of achyranthes bidentata, 5-10 parts of herba lycopi, 5-10 parts of ephedra, 5-10 parts of cape jasmine, 5-10 parts of mint and 10-15 parts of pawpaw. The preparation of the Chinese medicinal composition has no toxic or side effect, is applicable to a patient with a large-area wound and is low in cost.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, specifically, relate to a kind of Chinese medicine composition for alleviating pain and detumescence and preparation thereof.
Background technology
Current each hospitalize mode that swells and ache causing of fracturing is a lot, and peri-operation period is processed reducing swelling and alleviating pain doctor trained in Western medicine routine and controlled the symptoms such as patient's swelling pain with mannitol and non-steroidal drug.This treatment may bring GI irritation and Liver and kidney merit infringement side effect to patient, has limitation for the patient's medication that has the infringement of Liver and kidney merit.For solving traditional western medicine, what cause by analysis trauma fracture swells and ache as local symptom, thereby gives differential diagnosis in tcm and go to develop local topical Chinese medicine reducing swelling and alleviating pain effect from modern medicine medicine reason solving the side effect that Western medicine may bring.
Disclosing at present some adopts Chinese medicine to treat fracture etc., the pharmaceutical preparation of relief of symptoms, as CN101099786 discloses a kind of muscles and bones trauma ointment for the treatment of muscles and bones wound and preparation method thereof, its raw material is: 1～4 part of Radix Aconiti Kusnezoffii, Radix Aconiti 1-4 part, Rhizoma Drynariae 2-9 part, Cortex Albiziae 2-9 part, Cortex Acanthopancis 2-9 part, Herba Asari 2-9 part, Radix Notoginseng 2-9 part, Fructus Zanthoxyli 2-9 part, Radix Angelicae Dahuricae 2-9 part, Olibanum 2-9 part, Myrrha 2-9 part, Herba Ephedrae 2-9 part, Carapax et Plastrum Testudinis 2-9 part, Folium Artemisiae Argyi 2-9 part, Herba Lycopodii 2-9 part, Oleum Ricini 4-11 part, vaseline 15-30 part.This traditional Chinese herb medicine, has the effect of hemopoietic, granulation promoting, reducing swelling and alleviating pain, evident in efficacy for diseases such as treatment fracture, dislocation, articular sprain, anemofrigid-damp arthralgia, synovitis.In this prescription, blood circulation promoting and blood stasis dispelling and analgesic effect are to be improved.
CN1814238 discloses a kind of lotion for the treatment of fracture, the Chinese herbal and crude drugs preparations that belongs to treatment fracture, it is by following ingredients: Flos Carthami, Rhizoma Sparganii, Rhizoma Curcumae, Radix Stephaniae Tetrandrae, Semen Pittospori Glabrati, the Radix Angelicae Dahuricae, Radix Zanthoxyli, Radix Dipsaci, Radix Notoginseng, BAIMIANYE, Camphora, Caulis et Folium piperis, Radix Flemingiae Philippinensis, Rhizoma Polygoni Cuspidati, Lignum Sappan, epicarp of Juglans regia L., Herba pteridis vittatae, Radix Aconiti Kusnezoffii, above Chinese herbal medicine is boiled 40 minutes together with 50% Chinese liquor, filter and remove residue, obtain liquid medicine preparation, said preparation has reducing swelling and alleviating pain, dredge the meridian passage, the function of blood circulation promoting and blood stasis dispelling, do not need planter cast, only knochenbruch need be resetted, soak lotion with absorbent cotton and be attached to patient injury each 30 minutes, remove absorbent cotton, reducing swelling and alleviating pain rapidly, easy to use, safety, have no side effect, fracture patient is had to magical curative effect, its short treating period, alleviate the misery of fracture patient, through clinical verification for many years, its cure rate reaches 90%, be applicable to bonesetting, the outmoded treatment of turning round damage of traumatic injury and flesh labor.In this Chinese prescription, the assimilation effect of analgesic effect and medicine is poor, needs to be further improved.
The present invention overcomes side effect and the limitation thereof that traditional western medical treatment may bring, and has overcome the shortcoming of Chinese medicine preparation in prior art, invent a kind of respond well, can replace clinically and supplement the Chinese medicine for outer use of western medicine.For defect of the prior art, special proposition the present invention.
Summary of the invention
Primary goal of the invention of the present invention has been to propose a kind of Chinese medicine composition for alleviating pain and detumescence and preparation thereof.
In order to realize object of the present invention, the technical scheme of employing is:
A kind of Chinese medicine composition for alleviating pain and detumescence, described Chinese medicine composition is prepared from by the raw material of following weight portion: Radix Aconiti 10～15 weight portions, Radix Aconiti Kusnezoffii 10～15 weight portions, Fructus Zanthoxyli 10～15 weight portions, Radix Gentianae Macrophyllae 5～10 weight portions, Olibanum 5～10 weight portions, Myrrha 5～10 weight portions, the Radix Linderae 10～15 weight portions, Rhizoma Sparganii 5～10 weight portions, Rhizoma Curcumae 5～10 weight portions, Semen Persicae 5～10 weight portions, Flos Carthami 5～10 weight portions, Radix Angelicae Sinensis 5～10 weight portions, Rhizoma Et Radix Notopterygii 5～10 weight portions, Radix Angelicae Pubescentis 5～10 weight portions, Radix Achyranthis Bidentatae 5～10 weight portions, Herba Lycopi's 5～10 weight portions, Herba Ephedrae 5～10 weight portions, Fructus Gardeniae 5～10 weight portions, Herba Menthae 5～10 weight portions and Fructus Chaenomelis 10～15 weight portions.
The first optimal technical scheme of the present invention is, described Chinese medicine composition is prepared from by the raw material of following weight portion: Radix Aconiti 12～15 weight portions, Radix Aconiti Kusnezoffii 12～15 weight portions, Fructus Zanthoxyli 12～15 weight portions, Radix Gentianae Macrophyllae 8～10 weight portions, Olibanum 8～10 weight portions, Myrrha 8～10 weight portions, the Radix Linderae 12～15 weight portions, Rhizoma Sparganii 8～10 weight portions, Rhizoma Curcumae 8～10 weight portions, Semen Persicae 8～10 weight portions, Flos Carthami 8～10 weight portions, Radix Angelicae Sinensis 8～10 weight portions, Rhizoma Et Radix Notopterygii 8～10 weight portions, Radix Angelicae Pubescentis 8～10 weight portions, Radix Achyranthis Bidentatae 8～10 weight portions, Herba Lycopi's 8～10 weight portions, Herba Ephedrae 8～10 weight portions, Fructus Gardeniae 8～10 weight portions, Herba Menthae 8～10 weight portions and Fructus Chaenomelis 8～15 weight portions.
The second optimal technical scheme of the present invention is, described Chinese medicine composition is prepared from by the raw material of following weight portion: Radix Aconiti 15 weight portions, Radix Aconiti Kusnezoffii 15 weight portions, Fructus Zanthoxyli 15 weight portions, Radix Gentianae Macrophyllae 10 weight portions, Olibanum 10 weight portions, Myrrha 10 weight portions, the Radix Linderae 15 weight portions, Rhizoma Sparganii 10 weight portions, Rhizoma Curcumae 10 weight portions, Semen Persicae 10 weight portions, Flos Carthami 10 weight portions, Radix Angelicae Sinensis 10 weight portions, Rhizoma Et Radix Notopterygii 10 weight portions, Radix Angelicae Pubescentis 10 weight portions, Radix Achyranthis Bidentatae 10 weight portions, Herba Lycopi's 10 weight portions, Herba Ephedrae 10 weight portions, Fructus Gardeniae 10 weight portions, Herba Menthae 10 weight portions and Fructus Chaenomelis 15 weight portions.
The 3rd optimal technical scheme of the present invention is that the dosage form of described Chinese medicine composition is liquid preparation for external application.
The 4th optimal technical scheme of the present invention is, the preparation method of described liquid preparation for external application is: take by weight medical material, clean, add the water soaking 1～2 hour of 1～3 times of injection volume, decoct boiling after little fire decoct 1～2 hour, leach after medicinal liquid, add again the decocting of 1～2 times of injection volume to boil medicinal residues and rise rear little fire decoction 1～2 hour, leach medicinal liquid, merge 2 times medicinal liquid, filter, vacuum bagged is packed and be get final product.
Below technical scheme of the present invention is made further explanation.
Motherland's medical science thinks that trauma fracture causes the damage of muscles and bones venation, and QI and blood is impaired, hemorrhage, and the stasis of blood is long-pending not loose, qi depression to blood stasis, grain is obstructed and occurs pain.Not to the greatest extent, Tianjin blood circulation is not good enough for passages through which vital energy circulates blood stasis, causes local body fluid to gather and occurs swelling pain." Shengji Zonglu " thinks " menstruation disorder for water ", " stasis of blood is long-pending loose for swollen ".Therefore the mechanism of swelling is not from congestive edema formerly, water is strongly fragrant in rear, " the water stasis of blood is tied mutually, for swollen ".Thereby fracture initial stage swelling, sincerely keep " hindering from blood opinion " very correct beyond doubt, but emphasize simply blood circulation promoting and blood stasis dispelling, ignore promoting diuresis to eliminate damp pathogen, water is wet gathers, and also must aggravate blood-stasis internal-depression; Only blood circulation promoting and blood stasis dispelling and promoting diuresis to eliminate damp pathogen develop simultaneously, and can receive that the stasis of blood goes swollen moving back, and qi-blood-body fluid is in harmonious proportion, and extremity bones of the body collectively must be supported, the merit of fracture reparation early." dialectical record synthetism door " pointed out: the method for the treatment of by oral administration of medicines, must be take blood circulation and promoting silt as first, and the blood stasis of blood alive is not gone, and the stasis of blood does not go bone can not tie yet." the reason parallel prose ": the reason of external treatment, the i.e. reason for the treatment of by oral administration of medicines; The medicine of external treatment, i.e. the medicine for the treatment of by oral administration of medicines, different Fa Er." Plain Questions ": impairment of QI resulting in pain, injury of configuration resulting in swelling.Wound swell and ache medication also give blood-activating and qi-promoting pain relieving and use.In conjunction with above-mentioned analysis, curative effect is as follows:
Radix Aconiti, Radix Aconiti Kusnezoffii: pungent, bitter, hot, GUIXIN, liver,kidney,spleen warp; Wind-damp dispelling, antalgic; The hot liter of these product is loose bitter dry, " dredge profit rapidly, open the pass natural fibre line of meat, expulsion cold-damp ".Be good at expelling wind and removing dampness, dispelling cold by warming the meridian, has obvious analgesic effect.Containing multiple alkaloid, is mainly aconitine, isoaconitine, hypaconitine.
Radix Gentianae Macrophyllae: pungent, bitter, flat; Return stomach, liver, gallbladder meridian; Wind-damp dispelling, removing obstruction in the collateral to relieve pain; Pungent loose hardship is let out, and matter embellishes but not dry partially, is intercalation dose in wind medicine; With Radix Aconiti, Radix Aconiti Kusnezoffii and with strengthening analgesic effect; Contain three kinds of alkaloids, i.e. Radix Gentianae Macrophyllae alkaloid the first and second the third.
Fructus Zanthoxyli: this product has the pain effect of anesthesia, strengthens analgesic effect with said medicine mutual reinforcement between for using; This product contains volatile oil.
Olibanum, Myrrha: blood-activating and qi-promoting pain relieving is external wounds key medicine; Resinous.
The Radix Linderae: Xin Wen, promoting the circulation of QI to relieve pain effect, external can make local vascular dilation, blood circulation accelerate, relax muscle spasm pain.
Rhizoma Sparganii, Rhizoma Curcumae: arduous temperature; Return liver spleen channel; This product has the merit of removing blood stasis promoting the circulation of QI for relieving swelling pain relieving, can promote microcirculation reparation, is beneficial to the absorption of edema and hematoma.
Semen Persicae: bitter sweet flat; There is the merit of blood circulation promoting and blood stasis dispelling, blood flow retardance, blood obstacle are improved to effect.
Flos Carthami: the pungent temperature of this product, has the merit of promoting blood circulation to disperse blood clots and relieves pain.
Radix Angelicae Sinensis: this product Gan Xinwen; Have enrich blood, invigorate blood circulation, the merit of pain relieving.
Rhizoma Et Radix Notopterygii: the cold expelling that induces sweat, expelling wind and dampness, pain relieving; Play antipyretic, antiinflammatory action.
Radix Angelicae Pubescentis: expelling wind and dampness; Dispersing cold for relieving pain, has analgesia, calmness and antiinflammatory action.
Radix Achyranthis Bidentatae: promoting blood circulation to restore menstrual flow, has anti-inflammatory and analgesic effect.
Herba Lycopi: blood circulation promoting and blood stasis dispelling, line water detumescence, has the effect of promoting blood circulation and detumescence.
Fructus Gardeniae: clearing away heat-damp and promoting diuresis; Removing pathogenic heat from blood and toxic substance from the body, has the effect of reducing swelling and alleviating pain.
Fructus Chaenomelis: Fructus Chaenomelis has good relaxing muscles and tendons and activating QI and blood in the collateral effect, and energy removing dampness, by dispelling the wind and dampness pathogens arthralgia pain is commonly used, particularly key medicine of muscle arteries and veins contracture person.There is the effect of antiinflammatory relieving spasm to stop pain.
Herba Ephedrae, Herba Menthae: Herba Ephedrae, Herba Menthae relieving the exterior syndrome by diaphoresis, loosing the interspaces of skin and muscles, make medicine better see through skin and be beneficial to drug absorption, make medicine can reach focus and better play a role; Herba Menthae is found from modern medicine study can be by the transdermal penetration ability of the structural change medicine of change Stratum corneum lipids; Also the tip sensor that can excite nerve reduces tissue and oozes out the anti inflammation, detumescence and relieving pain effect of playing.
The present invention has increased Radix Gentianae Macrophyllae compared with CN101099786 and has increased the analgesic effect of Radix Aconiti and Radix Aconiti Kusnezoffii, and has assisted a large amount of promoting blood circulation, removing blood stasis and relieving pain medicines, stronger than promoting blood circulation, removing blood stasis and relieving pain effect.With CN1814238 relatively the present invention to have applied more analgesic drug product analgesic effect obvious, and add and promote that the assimilation effect of medicine is better with Herba Ephedrae and Herba Menthae.
Modern medicine think swelling be after fracture because local hemorrhage blood stasis, backflow obstacle and local nerve reflex irritation cause, the release of local hemorrhage wound and Inflammatory substances stimulates local pain.The liquid preparation for external application of Chinese medicine composition of the present invention can improve local blood fortune, promote local microcirculation to recover, promote the absorption of body fluid and blood stasis, and can reflex irritation teleneuron cause the contraction of blood vessel, alleviate and ooze out, thereby subside a swelling from these three aspects comprehensively; Chinese medicine composition of the present invention is without the pain medicine of application anesthesia and be equipped with and promote the medicine of drug absorption, can reach faster analgesic effect, thereby and the absorption of the auxiliary blood circulation promoting and blood stasis dispelling promotion absorption of hematoma of all the other medicines and Inflammatory substances indirectly play analgesic effect.And mannitol and lornoxicam treatment swelling and analgesic effect are more single.
Preparation of the present invention belongs to external preparation, the commodity bone by name lotion of healing, and the early stage amphibolia of fracturing, is using cotton pad or yarn piece as pharmaceutical carrier, continue external, effective ingredient is easy to skin and absorbs, rapid-action, and can keep the drug level in affected part, make sphere of action wide, effect is permanent.And use top treatment traumatic injury, have no side effect, overcome oral and stimulation and the infringement of intravenous administration reducing swelling and alleviating pain showy reiolaena root-bark to stomach.And being applicable to the patient of extensive wound, expense is lower.We suit etiology and pathogenesis, and the reasonable effect of principle-method-recipe-medicines is remarkable.Have rapid-action, act on permanent advantage, and easy operating and clean, is worthy of popularization.
The specific embodiment of the present invention only limits to further explain and explanation the present invention, not to Composition of contents restriction of the present invention.
The specific embodiment
Embodiment 1
For a Chinese medicine composition for alleviating pain and detumescence, below the raw material of weight portion be prepared from: Radix Aconiti 15 weight portions, Radix Aconiti Kusnezoffii 15 weight portions, Fructus Zanthoxyli 15 weight portions, Radix Gentianae Macrophyllae 10 weight portions, Olibanum 10 weight portions, Myrrha 10 weight portions, the Radix Linderae 15 weight portions, Rhizoma Sparganii 10 weight portions, Rhizoma Curcumae 10 weight portions, Semen Persicae 10 weight portions, Flos Carthami 10 weight portions, Radix Angelicae Sinensis 10 weight portions, Rhizoma Et Radix Notopterygii 10 weight portions, Radix Angelicae Pubescentis 10 weight portions, Radix Achyranthis Bidentatae 10 weight portions, Herba Lycopi's 10 weight portions, Herba Ephedrae 10 weight portions, Fructus Gardeniae 10 weight portions, Herba Menthae 10 weight portions and Fructus Chaenomelis 15 weight portions.
The dosage form of said composition is liquid preparation for external application, its preparation method is: take by weight medical material, clean, add the water soaking 1 hour of 2 times of injection volumes, decoct boiling after little fire decoct 1 hour, leach after medicinal liquid, add again the decocting of 1 times of injection volume to boil medicinal residues and rise rear little fire decoction 1 hour, leach medicinal liquid, merge 2 times medicinal liquid, filter, vacuum bagged is packed and be get final product.
Embodiment 2
For a Chinese medicine composition for alleviating pain and detumescence, below the raw material of weight portion be prepared from: Radix Aconiti 10 weight portions, Radix Aconiti Kusnezoffii 10 weight portions, Fructus Zanthoxyli 10 weight portions, Radix Gentianae Macrophyllae 5 weight portions, Olibanum 5 weight portions, Myrrha 5 weight portions, the Radix Linderae 10 weight portions, Rhizoma Sparganii 5 weight portions, Rhizoma Curcumae 5 weight portions, Semen Persicae 5 weight portions, Flos Carthami 5 weight portions, Radix Angelicae Sinensis 5 weight portions, Rhizoma Et Radix Notopterygii 5 weight portions, Radix Angelicae Pubescentis 5 weight portions, Radix Achyranthis Bidentatae 5 weight portions, Herba Lycopi's 5 weight portions, Herba Ephedrae 5 weight portions, Fructus Gardeniae 5 weight portions, Herba Menthae 5 weight portions and Fructus Chaenomelis 10 weight portions.
The dosage form of said composition is liquid preparation for external application, its preparation method is: take by weight medical material, clean, add the water soaking 2 hours of 3 times of injection volumes, decoct boiling after little fire decoct 2 hours, leach after medicinal liquid, add again the decocting of 1 times of injection volume to boil medicinal residues and rise rear little fire decoction 1 hour, leach medicinal liquid, merge 2 times medicinal liquid, filter, vacuum bagged is packed and be get final product.
Embodiment 3
For a Chinese medicine composition for alleviating pain and detumescence, below the raw material of weight portion be prepared from: Radix Aconiti 12 weight portions, Radix Aconiti Kusnezoffii 12 weight portions, Fructus Zanthoxyli 12 weight portions, Radix Gentianae Macrophyllae 8 weight portions, Olibanum 8 weight portions, Myrrha 8 weight portions, the Radix Linderae 12 weight portions, Rhizoma Sparganii 8 weight portions, Rhizoma Curcumae 8 weight portions, Semen Persicae 8 weight portions, Flos Carthami 8 weight portions, Radix Angelicae Sinensis 8 weight portions, Rhizoma Et Radix Notopterygii 8 weight portions, Radix Angelicae Pubescentis 8 weight portions, Radix Achyranthis Bidentatae 8 weight portions, Herba Lycopi's 8 weight portions, Herba Ephedrae 8 weight portions, Fructus Gardeniae 8 weight portions, Herba Menthae 8 weight portions and Fructus Chaenomelis 12 weight portions.
The dosage form of said composition is liquid preparation for external application, its preparation method is: take by weight medical material, clean, add the water soaking 2 hours of 2 times of injection volumes, decoct boiling after little fire decoct 1 hour, leach after medicinal liquid, add again the decocting of 1 times of injection volume to boil medicinal residues and rise rear little fire decoction 1 hour, leach medicinal liquid, merge 2 times medicinal liquid, filter, vacuum bagged is packed and be get final product.
Experimental example 1
1. formulate criterion of therapeutical effect with reference to WHO pain degree grade scale:
0 grade: completely without pain, detumescence 1.5～2.5cm;
I level: mild pain, painless or pain slightly while reposing, but do not need to use analgesic, detumescence 1.0～1.5cm;
II level: moderate pain, still can stand, when movable, increase the weight of detumescence 0.5～1.0cm;
III level: severe pain, can not stand, in the urgent need to using analgesic, below detumescence 0.5cm.
2. ordinary circumstance:
This experiment case selection: in January, 2005～2007 year January, choose 200 example fracture soft tissue injury patients, be divided at random two groups, Chinese medicine composition lotion prepared by experimental group embodiment 1, matched group is mannitol and lornoxicam dispersible tablet.
(1) experimental group 120 examples, wherein male 68 examples, female's 52 examples, at 18～70 years old age, morbidity is fracture of tibia and fibula;
(2) mannitol, lornoxicam dispersible tablet group 80 examples, male 36 examples, female's 44 examples, at 18～72 years old age, morbidity is fracture of tibia and fibula.
3. treatment monitoring method:
(1) experimental group: the Chinese medicine composition liquid formulation that adopts embodiment 1 to prepare, every bag of 200ml, row local wet dressing, when the drug of topical application, affected part covers cotton pad or yarn piece is fixed, and spoons Chinese medicine preparation, keeps dressing drench but do not drip, and keeps adjuvant moistening.
(2) mannitol, lornoxicam dispersible tablet: patient applies mannitol 250ml, and vein splashes into, every day twice, the each a slice of lornoxicam dispersible tablet (every 8mg), every day 2 warm water delivery services.Any medicine is not applied in part.
Each treatment group, respectively at first day, is added up effect on the 3rd day.
4. clinical evaluation
Swelling statistical effect is measured shank week footpath video data by traditional tape, and pain is by the comparison of WHO pain degree grade scale.
Statistics patient reducing swelling and alleviating pain situation of the 3rd day after medication, experimental group (120 example) reducing swelling and alleviating pain effect reaches 0, I level has 118 examples (98.3%), and only 46 examples (57.5%) of matched group (80 example), learn and process by statistics, two groups of therapeutic effect differences have significance (P<0.05).
Curative effect comparisons after two groups of treatments, in table 1:
Table 1:
| ? | n | 0 grade | 1 grade | 2 grades | 3 grades | Total effective rate (%) |
| Treatment group | 120 | 86 | 34 | 2 | 0 | 98.3 |
| Matched group | 80 | 32 | 14 | 34 | 0 | 57.5 |
Note: * P < 0.05, treatment group curative effect is obviously better than matched group.
This illustrates that the swelling pain effect that Chinese medicine composition lotion of the present invention causes as a kind of medicine for external use treatment fracture is sure, and the deficiency that the Chinese medicine composition lotion of the dialectical development by Chinese medicine can bring at the supplementary Western medicine of clinical practice be described.
The Chinese medicine composition lotion of the preparation of all the other embodiment of the present invention can reach same therapeutic effect.
Experimental example 2
1. formulate criterion of therapeutical effect with reference to WHO pain degree grade scale:
0 grade: completely without pain, detumescence 1.5～2.5cm;
I level: mild pain, painless or pain slightly while reposing, but do not need to use analgesic, detumescence 1.0～1.5cm;
II level: moderate pain, still can stand, when movable, increase the weight of detumescence 0.5～1.0cm;
III level: severe pain, can not stand, in the urgent need to using analgesic, below detumescence 0.5cm.
2. ordinary circumstance:
This experiment case selection: in January, 2005～2007 year January, choose 200 example fracture soft tissue injury patients, be divided at random two groups, Chinese medicine composition lotion prepared by experimental group embodiment, matched group is the preparation of formula described in comparative example 1.
Comparative example 1 is filled a prescription: Radix Aconiti 15 weight portions, Radix Aconiti Kusnezoffii 15 weight portions, Olibanum 10 weight portions, Myrrha 10 weight portions, the Radix Linderae 15 weight portions, Rhizoma Sparganii 10 weight portions, Rhizoma Curcumae 10 weight portions, Semen Persicae 10 weight portions, Flos Carthami 10 weight portions, Radix Angelicae Sinensis 10 weight portions, Rhizoma Et Radix Notopterygii 10 weight portions, Radix Angelicae Pubescentis 10 weight portions, Radix Achyranthis Bidentatae 10 weight portions, Herba Lycopi's 10 weight portions, Herba Ephedrae 10 weight portions, Fructus Gardeniae 10 weight portions, Herba Menthae 10 weight portions and Fructus Chaenomelis 15 weight portions.Preparation method is with embodiment 2.
(1) experimental group 100 examples, wherein male 52 examples, female's 48 examples, at 18～70 years old age, morbidity is fracture of tibia and fibula;
(2) 1 group of 100 example of comparative example, male 58 examples, female's 42 examples, at 18～72 years old age, morbidity is fracture of tibia and fibula.
3. treatment monitoring method:
Experimental group method: the Chinese medicine composition liquid formulation that adopts embodiment 2 to prepare, every bag of 200ml, row local wet dressing, when the drug of topical application, affected part covers cotton pad or yarn piece is fixed, and spoons Chinese medicine preparation, keeps dressing drench but do not drip, and keeps adjuvant moistening.
1 group of comparative example adopts this prescription drug preparation, the concrete same experimental group of using method.
Each treatment group, respectively at first day, is added up effect on the 3rd day.
4. clinical evaluation
Swelling statistical effect is measured shank week footpath video data by traditional tape, and pain is by the comparison of WHO pain degree grade scale.
Statistics patient reducing swelling and alleviating pain situation of the 3rd day after medication, experimental group (100 example) reducing swelling and alleviating pain effect reaches 0, I level has 98 examples (98%), and only 72 examples (72%) of matched group (100 example), learn and process by statistics, two groups of therapeutic effect differences have significance (P<0.05).
Curative effect comparisons after two groups of treatments, in table 2:
Table 2:
| ? | n | 0 grade | 1 grade | 2 grades | 3 grades | Total effective rate (%) |
| Treatment group | 100 | 70 | 18 | 10 | 2 | 98% |
| Matched group | 100 | 49 | 12 | 11 | 18 | 72% |
Note: * P < 0.05, treatment group curative effect is obviously better than matched group.
This formula that Chinese medicine composition of the present invention is described is respond well at the swelling pain causing for fracture.
Claims (4)
1. the Chinese medicine composition for alleviating pain and detumescence, it is characterized in that, described Chinese medicine composition is prepared from by the raw material of following weight portion: Radix Aconiti 10～15 weight portions, Radix Aconiti Kusnezoffii 10～15 weight portions, Fructus Zanthoxyli 10～15 weight portions, Radix Gentianae Macrophyllae 5～10 weight portions, Olibanum 5～10 weight portions, Myrrha 5～10 weight portions, the Radix Linderae 10～15 weight portions, Rhizoma Sparganii 5～10 weight portions, Rhizoma Curcumae 5～10 weight portions, Semen Persicae 5～10 weight portions, Flos Carthami 5～10 weight portions, Radix Angelicae Sinensis 5～10 weight portions, Rhizoma Et Radix Notopterygii 5～10 weight portions, Radix Angelicae Pubescentis 5～10 weight portions, Radix Achyranthis Bidentatae 5～10 weight portions, Herba Lycopi's 5～10 weight portions, Herba Ephedrae 5～10 weight portions, Fructus Gardeniae 5～10 weight portions, Herba Menthae 5～10 weight portions and Fructus Chaenomelis 10～15 weight portions, the dosage form of described Chinese medicine composition is liquid preparation for external application.
2. the Chinese medicine composition for alleviating pain and detumescence according to claim 1, it is characterized in that, described Chinese medicine composition is prepared from by the raw material of following weight portion: Radix Aconiti 12～15 weight portions, Radix Aconiti Kusnezoffii 12～15 weight portions, Fructus Zanthoxyli 12～15 weight portions, Radix Gentianae Macrophyllae 8～10 weight portions, Olibanum 8～10 weight portions, Myrrha 8～10 weight portions, the Radix Linderae 12～15 weight portions, Rhizoma Sparganii 8～10 weight portions, Rhizoma Curcumae 8～10 weight portions, Semen Persicae 8～10 weight portions, Flos Carthami 8～10 weight portions, Radix Angelicae Sinensis 8～10 weight portions, Rhizoma Et Radix Notopterygii 8～10 weight portions, Radix Angelicae Pubescentis 8～10 weight portions, Radix Achyranthis Bidentatae 8～10 weight portions, Herba Lycopi's 8～10 weight portions, Herba Ephedrae 8～10 weight portions, Fructus Gardeniae 8～10 weight portions, Herba Menthae 8～10 weight portions and Fructus Chaenomelis 8～15 weight portions.
3. the Chinese medicine composition for alleviating pain and detumescence according to claim 1, it is characterized in that, described Chinese medicine composition is prepared from by the raw material of following weight portion: Radix Aconiti 15 weight portions, Radix Aconiti Kusnezoffii 15 weight portions, Fructus Zanthoxyli 15 weight portions, Radix Gentianae Macrophyllae 10 weight portions, Olibanum 10 weight portions, Myrrha 10 weight portions, the Radix Linderae 15 weight portions, Rhizoma Sparganii 10 weight portions, Rhizoma Curcumae 10 weight portions, Semen Persicae 10 weight portions, Flos Carthami 10 weight portions, Radix Angelicae Sinensis 10 weight portions, Rhizoma Et Radix Notopterygii 10 weight portions, Radix Angelicae Pubescentis 10 weight portions, Radix Achyranthis Bidentatae 10 weight portions, Herba Lycopi's 10 weight portions, Herba Ephedrae 10 weight portions, Fructus Gardeniae 10 weight portions, Herba Menthae 10 weight portions and Fructus Chaenomelis 15 weight portions.
4. according to the Chinese medicine composition for alleviating pain and detumescence described in the arbitrary claim of claim 1～3, it is characterized in that, the preparation method of described liquid preparation for external application is: take by weight medical material, clean, add the water soaking 1～2 hour of 1～3 times of injection volume, after decocting boiling, little fire decocts 1～2 hour, leach after about medicinal liquid, add again the decocting of 1～2 times of injection volume to boil medicinal residues and rise rear little fire decoction 1～2 hour, leach medicinal liquid, merge 2 times medicinal liquid, filter, vacuum bagged is packed and be get final product.
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| CN104258307A (en) * | 2014-10-20 | 2015-01-07 | 许崇波 | Traditional Chinese medicine combination for relieving swelling and pain after fracture |
| CN104888052B (en) * | 2015-04-28 | 2018-09-28 | 林瑞将 | A kind of alleviating pain and detumescence repairs lotion and preparation method thereof |
| CN108524649B (en) * | 2018-04-10 | 2021-04-30 | 王庆普 | Gel preparation for dredging collaterals and relieving pain and preparation method thereof |
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| CN1269206A (en) * | 1999-04-06 | 2000-10-11 | 哈尔滨太阳岛制药厂 | Making process of Babu plaster for rheumatism and ostealiga |
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| CN1269206A (en) * | 1999-04-06 | 2000-10-11 | 哈尔滨太阳岛制药厂 | Making process of Babu plaster for rheumatism and ostealiga |
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| Title |
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| 《中医辨证论治痹证》;吴卫红;《辽宁中医杂志》;20030430;第30卷(第4期);279 * |
| 《身痛逐瘀汤治疗痹症40例体会》;尹发清;《云南中医中药杂志》;19971231;第18卷(第5期);15-16 * |
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