CN104225435A

CN104225435A - Traditional Chinese medicine preparation for treating turbid phlegm obstructing type coronary heart disease

Info

Publication number: CN104225435A
Application number: CN201410475952.9A
Authority: CN
Inventors: 戚光祖; 王彦丽
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-09-10
Filing date: 2014-09-10
Publication date: 2014-12-24

Abstract

The invention discloses a traditional Chinese medicine preparation for treating the turbid phlegm obstructing type coronary heart disease. According to the pathogenesis of the turbid phlegm obstructing type coronary heart disease, chest enlargement, phlegm elimination, blood stasis removal and stagnation elimination can be realized through the traditional Chinese medicine treatment. Thus, traditional Chinese medicines, namely, picris hieracioides, cremanthodium reniforme, ligularia sibirica, Japanese ginseng rhizome, boxleaf atalantia roots, mustard leaves, villous amomum flowers and peduncles, concha arcae, szechwan goldenray roots, sea-buckthorn, wilson's passion flowers and Japanese angelica tree root bark are selected and decocted with water into a decoction in a preparation room of the hospital, clinical tests indicate that the total effective rate is up to 94% and is obviously higher than 82% of a control group, and the preparation is significant in curative effect and small in side effect.

Description

A kind of Chinese medicine preparation for the treatment of expectorant turbid heap soil or fertilizer over and around the roots resistance type coronary heart disease

Technical field

The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of Chinese medicine preparation for the treatment of expectorant turbid heap soil or fertilizer over and around the roots resistance type coronary heart disease.

Background technology

Coronary heart disease is because coronary artery occurs atherosis, tube chamber coronarius is occurred narrow or inaccessible, thus causes a kind of heart disease of myocardial ischemia, ischemia.In the past, mainly use doctor trained in Western medicine Routine Treatment Therapy For Instability coronary heart disease clinically, but effect is general, untoward reaction is serious.Chinese medicine is under the guidance of Overall View, not only consider the various paathogenic factors of coronary heart disease, also note the prosperity and decline of whole body negative and positive of qi and blood, not only emphasize the local patholoic change of arteria coronaria (heart arteries and veins heart network), the globality more paying attention to itself and whole body contacts, therefore Chinese medicine on the whole determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs coronary heart disease often obtain good curative effect, the patient especially long for the course of disease, the state of an illness is comparatively obstinate, relatively advantageously.Applicant shows through clinical research for many years, based on Chinese medicine or combination of Chinese and Western medicine curative effect be better than simple western medicine treatment, to control symptom, prevent complication, reduce case fatality rate play an important role.

Summary of the invention

The object of this invention is to provide a kind of Chinese medicine preparation for the treatment of expectorant turbid heap soil or fertilizer over and around the roots resistance type coronary heart disease.For the pathogenesis of expectorant turbid heap soil or fertilizer over and around the roots resistance type coronary heart disease, the suitable the chest stuffiness relieving eliminating phlegm of Chinese traditional treatment, blood stasis-eliminating and stagnation-dissipating.

The object of the invention is to be achieved through the following technical solutions, the Chinese medicine preparation of this treatment expectorant turbid heap soil or fertilizer over and around the roots resistance type coronary heart disease is made up of the Chinese medicine of following weight portion: Fols Picridis fuscipilosae 10-15 part, Herba Cremanthodii plantaginei 6-10 part, Radix Ligulariae Dentatae 3-9 part, Rhizoma Panacis japonici 3-9 part, Radix Atalantiae Buxifoliae 15-20 part, Caulis et Folium Brassicae junceae 10-15 part, Flos Amomi villosi 1-2 part, Concha Arcae 8-12 part, Radix Ligulariae sutchuenensis 9-15 part, fructus hippophae 9-15 part, Herba Passiflorae Wilsonii 8-12 part, Cortex Araliae Elatae Radicis 25-35 part.

Preferably, Fols Picridis fuscipilosae 13 parts, Herba Cremanthodii plantaginei 8 parts, Radix Ligulariae Dentatae 6 parts, Rhizoma Panacis japonici 6 parts, Radix Atalantiae Buxifoliae 17 parts, 13 parts, Caulis et Folium Brassicae junceae, Flos Amomi villosi 1.5 parts, Concha Arcae 10 parts, Radix Ligulariae sutchuenensis 12 parts, fructus hippophae 12 parts, Herba Passiflorae Wilsonii 10 parts, Cortex Araliae Elatae Radicis 30 parts.

Above-mentioned Chinese medicine decocting is made decoction by preparation method.

Fang Zhong: Fols Picridis fuscipilosae is reduced phlegm, relieving asthma, the chest stuffiness relieving; Herba Cremanthodii plantaginei expelling phlegm for arresting cough, the chest stuffiness relieving promoting the circulation of QI; Radix Ligulariae Dentatae relieving cough and resolving phlegm, regulate the flow of vital energy, stop blooding, invigorate blood circulation; Rhizoma Panacis japonici relieving cough and resolving phlegm, removing blood stasis and activating blood flow; Radix Atalantiae Buxifoliae reduces phlegm pleasant, stasis-dispelling and pain-killing; Caulis et Folium Brassicae junceae lung qi dispersing eliminating phlegm, warming middle-JIAO are regulated the flow of vital energy; Flos Amomi villosi the chest stuffiness relieving is regulated the flow of vital energy, is eliminated the phlegm; Concha Arcae reduces phlegm, softening the hard mass, dissipating blood stasis, removing food stagnancy; Radix Ligulariae sutchuenensis blood circulation promoting competent silt; Fructus hippophae removing blood stasis and activating blood flow, the chest stuffiness relieving that reduces phlegm, spleen reinforcing stomach invigorating; Herba Passiflorae Wilsonii promoting blood circulation by removing blood stasis, relaxing muscles and tendons and activating QI and blood in the collateral; Cortex Araliae Elatae Radicis invigorating QI and tranquilization, essence strengthening and the kidney invigorating, dispelling, collateral-activating.

Clinical data

1, the 100 routine patients with coronary heart disease that during object of this research of physical data is in January, 2008 ~ 2010 year April, my institute accepts for medical treatment.This 100 routine patient all meets the diagnostic criteria of the coronary heart disease specified clinically, and they all exist obvious myocardial ischemia symptom under quiescent condition.This 100 routine patient is divided into observation group and matched group by random, has often organized 50 routine patients.In 50 routine patients of observation group, there is female patient 30 example, male patient 20 example.Age, the mean age was 62.8 years old between 42 ~ 77 years old; The course of disease is between 7 months ~ 4 years, and average course of disease is 2.1 years.In 50 routine patients of matched group, there is female patient 28 example, male patient 22 example.Age, the mean age was 61.2 years old between 40 ~ 74 years old; The course of disease is between 9 months ~ 5 years, and average course of disease is 2.2 years.Two groups of patients compare there was no significant difference (P > 0.05) in the physical data such as sex, age, the course of disease, have comparability.

2, diagnostic criteria with ictal chest pain for main clinical manifestation: panic attacks generally has inducement; Painful area is mainly after breastbone or pareordia; Characteristic of pain is compressing, stuffy or constriction; The each 3-5 minute of durante dolors, generally alleviates after with nitroglycerin in stopping inducement or Sublingual.

Electrocardiogram: great majority can occur that when showing effect the ST section of leading in combination that transience myocardial ischemia causes moves down > 0.05mv or raises > 0.1mv, or electrocardiogram stress test is positive.

Expectorant turbid heap soil or fertilizer over and around the roots resistance type coronary heart disease differential diagnosis in tcm disease: the vexed plug in ambition, hypopnea, abundant expectoration of breathing hard, obesity, limbs are heavy, and tongue fur neatly or yellow greasy or turbid greasy, pulse condition is sliding.

3, Therapeutic Method treatment group uses Chinese medicine preparation of the present invention, take Fols Picridis fuscipilosae 13g, Herba Cremanthodii plantaginei 8g, Radix Ligulariae Dentatae 6g, Rhizoma Panacis japonici 6g, Radix Atalantiae Buxifoliae 17g, Caulis et Folium Brassicae junceae 13g, Flos Amomi villosi 1.5g, Concha Arcae 10g, Radix Ligulariae sutchuenensis 12g, fructus hippophae 12g, Herba Passiflorae Wilsonii 10g, Cortex Araliae Elatae Radicis 30g, decocting makes decoction, every day potion, after meal half an hour early, each sub-service in evening.

Matched group selects isosorbide dinitrate tablets.The usage of this medicine is: take 2 every day, each serving 50 milligrams.All treating for two groups 4 weeks is a course for the treatment of.

4, criterion of therapeutical effect is cured: after taking medicine, angina pectoris symptom disappears, and Electrocardioscopy is normal; Effective: after taking medicine, angina pectoris frequency reduces >=70%, and electrocardiogram comparatively before has clear improvement, normal; Effective: after taking medicine, angina pectoris number of times reduces >=50%, and electrocardiogram makes moderate progress, but still have positive change; Invalid: after taking medicine, angina pectoris number of times reduces < 50%, electrocardiogram even increases the weight of without improvement substantially.

5, therapeutic outcome two groups of patient treatments 4 weeks rear observe the curative effect, the routine patient for the treatment of group 50, wherein clinical cure 10 example (20%), effective 22 examples (44%), effective 15 examples (30%), invalid 3 examples (6%), total effective rate 94%, evident in efficacy.The routine patient of matched group 50, wherein clinical cure 5 example (10%), effective 15 examples (30%), effective 21 examples (42%), no effect 9 (18%), total effective rate 82%.Treatment group cure rate and total effective rate are apparently higher than matched group (P < 0.05).The symptoms such as in whole therapeutic process, matched group patient has 8 examples to occur dizziness, and 3 examples occur dizzy, sleepy, after drug withdrawal, symptom alleviates to disappearance.Treatment group has 2 examples to occur gastrointestinal side effect, learns that its ante cibum takes medicine, after advise its one after each meal, untoward reaction alleviates to disappearance.

Detailed description of the invention

Embodiment one: take Fols Picridis fuscipilosae 13g, Herba Cremanthodii plantaginei 8g, Radix Ligulariae Dentatae 6g, Rhizoma Panacis japonici 6g, Radix Atalantiae Buxifoliae 17g, Caulis et Folium Brassicae junceae 13g, Flos Amomi villosi 1.5g, Concha Arcae 10g, Radix Ligulariae sutchuenensis 12g, fructus hippophae 12g, Herba Passiflorae Wilsonii 10g, Cortex Araliae Elatae Radicis 30g, makes decoction by above-mentioned Chinese medicine decocting.

Embodiment two: take Fols Picridis fuscipilosae 15g, Herba Cremanthodii plantaginei 6g, Radix Ligulariae Dentatae 9g, Rhizoma Panacis japonici 3g, Radix Atalantiae Buxifoliae 20g, Caulis et Folium Brassicae junceae 15g, Flos Amomi villosi 2g, Concha Arcae 8g, Radix Ligulariae sutchuenensis 15g, fructus hippophae 9g, Herba Passiflorae Wilsonii 12g, Cortex Araliae Elatae Radicis 35g, makes decoction by above-mentioned Chinese medicine decocting.

Embodiment three: take Fols Picridis fuscipilosae 10g, Herba Cremanthodii plantaginei 10g, Radix Ligulariae Dentatae 3g, Rhizoma Panacis japonici 9g, Radix Atalantiae Buxifoliae 15g, Caulis et Folium Brassicae junceae 10g, Flos Amomi villosi 1g, Concha Arcae 12g, Radix Ligulariae sutchuenensis 9g, fructus hippophae 15g, Herba Passiflorae Wilsonii 8g, Cortex Araliae Elatae Radicis 25g, makes decoction by above-mentioned Chinese medicine decocting.

Claims

1. treat a Chinese medicine preparation for expectorant turbid heap soil or fertilizer over and around the roots resistance type coronary heart disease, it is characterized in that this Chinese medicine preparation is made up of the Chinese medicine of following weight portion: Fols Picridis fuscipilosae 10-15 part, Herba Cremanthodii plantaginei 6-10 part, Radix Ligulariae Dentatae 3-9 part, Rhizoma Panacis japonici 3-9 part, Radix Atalantiae Buxifoliae 15-20 part, Caulis et Folium Brassicae junceae 10-15 part, Flos Amomi villosi 1-2 part, Concha Arcae 8-12 part, Radix Ligulariae sutchuenensis 9-15 part, fructus hippophae 9-15 part, Herba Passiflorae Wilsonii 8-12 part, Cortex Araliae Elatae Radicis 25-35 part.

2. a kind of Chinese medicine preparation for the treatment of expectorant turbid heap soil or fertilizer over and around the roots resistance type coronary heart disease as claimed in claim 1, is characterized in that Fols Picridis fuscipilosae 13 parts, Herba Cremanthodii plantaginei 8 parts, Radix Ligulariae Dentatae 6 parts, Rhizoma Panacis japonici 6 parts, Radix Atalantiae Buxifoliae 17 parts, 13 parts, Caulis et Folium Brassicae junceae, Flos Amomi villosi 1.5 parts, Concha Arcae 10 parts, Radix Ligulariae sutchuenensis 12 parts, fructus hippophae 12 parts, Herba Passiflorae Wilsonii 10 parts, Cortex Araliae Elatae Radicis 30 parts.