CN103977255A - Chinese herbal preparation for treating coronary atherosclerotic heart disease angina pectoris - Google Patents

Abstract

The invention discloses a Chinese herbal preparation for treating coronary atherosclerotic heart disease angina pectoris. Doctors of traditional Chinese medicine think that the coronary atherosclerotic heart disease angina pectoris belongs to the ranges of heart impediment, thoracic obstruction and angina pectoris in the traditional Chinese medicine. Yang-qi deficiency of the upper-jiao is the root cause; based on that, because of the occurrence of turbid pathogenic factor and repression of yang-qi of chest, stagnation of the circulation of vital energy, blood stasis and turbid phlegm are formed. According to the Chinese herbal preparation, the Chinese traditional medicines like phyllostachys bambusoides wormseed mustard, ginseng fruits, polyandrous balanophora, flower of franchet peashrub, linearleaf thistle root, Yunnan dysosma tuber, kamuning, exocarpium, caudate sweetleaf flower, purple actinidia and latouchea fokiensis having functions of tonifying the spleen and replenishing the qi, nourishing the yin and tonifying the kidney, promoting blood circulation for removing blood stasis and dehumidifying and eliminating phlegm are decocted with water so as to prepare a decoction. The clinical test in the hospital shows that the curative effect is significant, the clinical symptoms are improved, the toxic side effect is avoided, and the treatment cost is low.

Description

A kind of Chinese medicine preparation for the treatment of Coronary atherosclerosis heart disease

Technical field

The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine preparation for the treatment of Coronary atherosclerosis heart disease.

Background technology

Coronary atherosclerotic heart disease (coronary atherosclerotic heart disease) is called for short coronary heart disease, refer to because lipid metabolism is undesired, lipid calmness in blood is on the endarterium of otherwise smooth, pile up and form white speckle at the lipid material of some similar medicated porridge samples of endarterium, be called atherosclerotic lesion.These specklees gradually increase and cause lumen of artery narrow, and blood flow is obstructed, and cause heart ischemia, produce angina pectoris.If the Mottling formation ulcer on arterial wall or break, will form thrombosis, whole vascular flow is interrupted completely, there is acute myocardial infarction, even sudden death.The rare pathogenesis of coronary heart disease is coronary vasospasm (blood vessel can not have atherosis), produces ariant angina, if spasm more than 30 minutes also can cause acute myocardial infarction (even sudden death).Coronary atherosclerotic heart disease is the commonly encountered diseases of serious harm human health, be in recent years and increase trend, Coronary atherosclerosis heart disease is common clinical frequently-occurring disease, doctor trained in Western medicine is in treatment all with Western medicine conventional therapy at present, and the insensitive alleviation of some patients were is outbreak more repeatedly.Applicant proves through clinical practice for many years, and this disease for the treatment of by Chinese herbs is not only evident in efficacy, and side effect is little, is difficult for recurrence.

Summary of the invention

The object of this invention is to provide a kind of Chinese medicine preparation for the treatment of Coronary atherosclerosis heart disease, Coronary atherosclerosis heart disease belongs to " obstruction of heart-QI ", " thoracic obstruction ", " angina pectoris " category of the traditional Chinese medical science.' the base outline of hideing) in say " husband's paying attention to pulse condition about hyperaction or hypoaction. positive war proclamation setting forth the purpose of the expedition and enumerating the crimes of the enemy YIN pulse being stringy.Be chest obstruction with pain. reason person. blame its plate void also. overstate weak pulse at YANG indicating deficiency of upper-JIAO, so obstruction of qi in the chest and cardialgia person, therefore with its YIN pulse being stringy also, explicitly pointing out part of the body cavity above the diaphragm housing the heart and lungs deficiency of YANG QI is root rate reason, and on this basis, turbid pathogen is superior, checks breast sun, forms the stagnation of QI, blood stasis, expectorant turbid.Make blood chant obstructed and angina pectoris occurs, pathogenic characteristic is deficiency in origin and excess in superficiality, and the real mainly finger of mark blood stasis, the stagnation of QI, epidemic disease are turbid.Chinese traditional treatment should be good for Pi QI invigorating, nourishing YIN for benefiting the kidney, blood circulation promoting and blood stasis dispelling, dehumidifying and be reduced phlegm.

The object of the invention is to be achieved through the following technical solutions, the Chinese medicine preparation of this treatment Coronary atherosclerosis heart disease is to be made up of the Chinese medicine of following amount part: Herba erysimi cheiranthoidis 10-15 part, Herba Herminii 15-20 part, Herba Balanophorae polyandrae 5-10 part, Flos Caraganae Franchetianae 7-12 part, Herba Cirsii linearis 20-25 part, dysosma auranticocaulis (Hand. Mazz.) Hu 3-5 part, Folium Et Cacumen Murrayae 8-12 part, Exocarpium Citri Grandis 3-6 part, Flos Symplocoris Caudatae 10-15 part, Radix seu Fructus Actinidiae Purpureae 25-35 part, Radix limonii sinensis 15-20 part.

Preferably, 13 parts of Herba erysimi cheiranthoidiss, 18 parts of Herba Herminii, 7 parts of Herba Balanophorae polyandraes, 9 parts of Flos Caraganae Franchetianae, 23 parts of Herba Cirsii lineariss, 4 parts of dysosma auranticocaulis (Hand. Mazz.) Hus, 10 parts of Folium Et Cacumen Murrayae, 5 parts of Exocarpium Citri Grandises, 12 parts of Flos Symplocoris Caudatae parts, 30 parts of Radix seu Fructus Actinidiae Purpureaes, 18 parts of Radix limonii sinensis.

Preparation method is made decoction by traditional method by above-mentioned Chinese medicine decocting.

Fang Zhong: Herba erysimi cheiranthoidis, the kidney invigorating of Herba Herminii heart tonifying, promoting the production of body fluid to quench thirst, invigorating the spleen and regulating the stomach; Herba Balanophorae polyandrae, Flos Caraganae Franchetianae enriching yin and nourishing kidney, QI invigorating kidney tonifying; Herba Cirsii linearis, dysosma auranticocaulis (Hand. Mazz.) Hu, Folium Et Cacumen Murrayae promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain; Exocarpium Citri Grandis, Flos Symplocoris Caudatae phlegm-eliminiating and qi-regulating, stomach invigorating; Radix seu Fructus Actinidiae Purpureae, Radix limonii sinensis damp eliminating heat clearing away, tonify deficiency benefit is damaged.

Clinical data

1. physical data is selected 240 routine Coronary atherosclerosis heart disease patients, is divided into two groups, treatment group 120 examples, wherein male 42 examples, female's 78 examples: year at age (45～65), average 52.6 years old; Matched group 120 examples, wherein male 40 examples, female's 80 examples; Age (49～65 years old), average 55.8 years old.Two groups of patients are not remarkable at sex, age each side comparing difference, and not statistically significant (P > 0.05), has comparability.Two groups of patients are all diagnosed as Coronary atherosclerosis heart disease with reference to " practical internal medicine " and " modern coronary heart disease " diagnostic criteria.

2. the coronary disease pain angina diagnostic criteria of diagnostic criteria reference WHO announcement in 1979 is made a definite diagnosis, and (in 3 days) have angina pectoris to show effect continuously 3 times above, the important organ diseases such as non-diabetic, cerebrovascular disease and other hearts, liver, kidney in the recent period.

3. Therapeutic Method treatment group patient takes Chinese medicine preparation of the present invention, take Herba erysimi cheiranthoidis 13g, Herba Herminii 18g, Herba Balanophorae polyandrae 7g, Flos Caraganae Franchetianae 9g, Herba Cirsii linearis 23g, dysosma auranticocaulis (Hand. Mazz.) Hu 4g, Folium Et Cacumen Murrayae 10g, Exocarpium Citri Grandis 5g, Flos Symplocoris Caudatae 12g, Radix seu Fructus Actinidiae Purpureae 30g, Radix limonii sinensis 18g, every day, potion, divided a secondary to take; Evening Primrose Oil for matched group (Tianjin Central Pharmaceutical 2nd Factory produces, lot number 950108) 1.5g, every day 2 times.Two groups of homogeneous are a course for the treatment of in individual month.

4. criterion of therapeutical effect is effective: when tranquillization checks, electrocardiogram recovers normal, and angina pectoris symptom disappears or attack times reduces more than 80%; Effective: when tranquillization, check electrocardiogram, ischemic ST declines before treatment more than rise 0.5mV, and the T ripple that mainly leads becomes more than 50%, or T ripple by smooth transfer to upright, angina pectoris symptom attack times minimizing 50%～80%; Invalid: after treatment, angina pectoris attacks number of times is treated front minimizing lower than 50%, when tranquillization, check that electrocardiogram and treatment are front without very changing; Increase the weight of: after treatment, angina pectoris symptom attack degree, number of times and persistent period have before treating and increase the weight of, mV.Tranquillization checks electrocardiogram, and the decline of ST section again declines and is greater than 0.5 before treatment.

5. after therapeutic outcome (1) is treated a course for the treatment of, two groups of patient's traditional Chinese medical science disease curative effects are relatively in table 1.

Table 1 liang group patient's traditional Chinese medical science disease curative effect comparison (%)

Two groups are compared P < 0.05

As can be seen from Table 1, two groups of patients' traditional Chinese medical science disease treatment total effective rate comparison, the total effective rate for the treatment of group is apparently higher than matched group, and two groups relatively have significant difference.P＜0.05

(2) treatment a course for the treatment of after two groups of patient's electrocardiograms relatively in table 2.

Table 2 is treated two groups of patient's electrocardiograms comparison after a course for the treatment of

Two groups are compared P < 0.05

As can be seen from Table 2, Electrocardiography comparison after two groups of patient treatments, the total effective rate for the treatment of group is apparently higher than matched group, two groups of relatively there were significant differences P < 0.05.

Detailed description of the invention

Embodiment mono-: take Herba erysimi cheiranthoidis 13g, Herba Herminii 18g, Herba Balanophorae polyandrae 7g, Flos Caraganae Franchetianae 9g, Herba Cirsii linearis 23g, dysosma auranticocaulis (Hand. Mazz.) Hu 4g, Folium Et Cacumen Murrayae 10g, Exocarpium Citri Grandis 5g, Flos Symplocoris Caudatae 12g, Radix seu Fructus Actinidiae Purpureae 30g, Radix limonii sinensis 18g.

Embodiment bis-: take Herba erysimi cheiranthoidis 15g, Herba Herminii 20g, Herba Balanophorae polyandrae 10g, Flos Caraganae Franchetianae 12g, Herba Cirsii linearis 25g, dysosma auranticocaulis (Hand. Mazz.) Hu 5g, Folium Et Cacumen Murrayae 12g, Exocarpium Citri Grandis 6g, Flos Symplocoris Caudatae 15g, Radix seu Fructus Actinidiae Purpureae 35g, Radix limonii sinensis 20g.

Embodiment tri-: take Herba erysimi cheiranthoidis 10g, Herba Herminii 15g, Herba Balanophorae polyandrae 5g, Flos Caraganae Franchetianae 7g, Herba Cirsii linearis 20g, dysosma auranticocaulis (Hand. Mazz.) Hu 3g, Folium Et Cacumen Murrayae 8g, Exocarpium Citri Grandis 3g, Flos Symplocoris Caudatae 10g, Radix seu Fructus Actinidiae Purpureae 25g, Radix limonii sinensis 15g.

Claims (2)

1. treat a Chinese medicine preparation for Coronary atherosclerosis heart disease, it is characterized in that this Chinese medicine preparation is made up of the Chinese medicine of following weight portion: Herba erysimi cheiranthoidis 10-15 part, Herba Herminii 15-20 part, Herba Balanophorae polyandrae 5-10 part, Flos Caraganae Franchetianae 7-12 part, Herba Cirsii linearis 20-25 part, dysosma auranticocaulis (Hand. Mazz.) Hu 3-5 part, Folium Et Cacumen Murrayae 8-12 part, Exocarpium Citri Grandis 3-6 part, Flos Symplocoris Caudatae 10-15 part, Radix seu Fructus Actinidiae Purpureae 25-35 part, Radix limonii sinensis 15-20 part.

2. a kind of Chinese medicine preparation for the treatment of Coronary atherosclerosis heart disease according to claim 1, is characterized in that this Chinese medicine preparation is made up of the Chinese medicine of following weight portion: 13 parts of Herba erysimi cheiranthoidiss, 18 parts of Herba Herminii, 7 parts of Herba Balanophorae polyandraes, 9 parts of Flos Caraganae Franchetianae, 23 parts of Herba Cirsii lineariss, 4 parts of dysosma auranticocaulis (Hand. Mazz.) Hus, 10 parts of Folium Et Cacumen Murrayae, 5 parts of Exocarpium Citri Grandises, 12 parts of Flos Symplocoris Caudatae parts, 30 parts of Radix seu Fructus Actinidiae Purpureaes, 18 parts of Radix limonii sinensis.