Summary of the invention
The invention provides a kind of Chinese medicine preparation and preparation method for the treatment of lung tumors; Chinese medicine preparation of the present invention selects rare Chinese medicine scientific composition; there is effect of benefiting qi and removing blood stasis, heat-clearing and toxic substances removing; immunity of organism resistance can be improved while the growth of inhibition tumor cell, increase leucocyte content, protection hemopoietic function of bone marrow; improve patient's ill symptoms and sign; be mainly used in the treatment of the tumors such as lung tumors, breast carcinoma, gastric cancer, also can be used for the postoperative adjuvant therapy of above-mentioned cancer, antitumor action is obvious; safe without toxic side effect is an important breakthrough of oncotherapy.
For achieving the above object, technical scheme of the present invention is implemented as follows:
Treat a Chinese medicine preparation for lung tumors, raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
Treat a preparation method for the Chinese medicine preparation of lung tumors, comprise following processing step:
(1) Pericarpium Pyri, Fructus Momordicae, Fructus Forsythiae, northern bedstraw, Lignum et Radix Naucleae and Semen Raphani are cleaned, put into container, add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate, for subsequent use;
(2) Folium et Ramulus Callicarpae nudiflorae, Folium Callicarpae Formosanae, Caulis Trachelospermi and Herba Asari Forbesii are cleaned, immerse the alcohol solution dipping 1 ~ 2 hour of 70% of 3 times amount, heating extraction 3 hours, reclaim ethanol, filter, at simmer down to 65 DEG C, relative density is the thick paste of 1.10 ~ 1.12, for subsequent use;
(3) after Radix Hemsleyae Macrospermae, Pericarpium Lagenariae sicerariae, Radix Tinosporae and Semen Ginkgo decontamination being cleaned, dry, be placed in mortar and grind into powder, cross 160 order fine powders, for subsequent use;
(4) Herba Sonchi Oleracei and Rhizoma Nelumbinis decontamination are cleaned, put into container, rub with agitator, filter impurity, stays juice for subsequent use;
(5) by the filtrate obtained by above-mentioned steps (1) ~ (4), thick paste, fine powder and juice mixing, make capsule, be the Chinese medicine preparation for the treatment of lung tumors of the present invention.
The property of medicine of the present invention's Chinese medicine used is as follows:
Pericarpium Pyri: sweet in the mouth, puckery, cool in nature, nontoxic; Return lung, the heart, kidney, large intestine channel.Clearing away heart-fire and moistening the lung, pathogenic fire reducing promotes the production of body fluid, and separates sore.Cure mainly summer-heat excessive thirst, xeropulmonary cough, spit blood, dysentery, scabies, carbuncle on the back, furuncle." book on Chinese herbal medicine is new again " carries: " quench the thirst in main Tianjin, relieving restlessness is dried for clearing heart fire, nourishing kidney tonifying YIN.”
Folium et Ramulus Callicarpae nudiflorae: micro-hardship, property is put down.Hemostasis and anti-inflammation, stasis-dispelling and pain-killing.Cure mainly pneumorrhagia type leptospirosis, pulmonary tuberculosis, lung abscess, it is hemorrhage that lobar pneumonia etc. cause, Peptic Ulcers etc." Nanning City's medicine will " carries: " hemostasis, pain relieving.Control traumatic injury, gunshot wound." modern medicine confirmation, Folium et Ramulus Callicarpae nudiflorae has hemostasis, antibacterial and wind dispelling detumescence effect.
Radix Hemsleyae Macrospermae: bitter in the mouth, cold in nature, slightly poisonous.Heat-clearing and toxic substances removing, benefiting stomach and stopping pain.For stomachache, Peptic Ulcers, upper respiratory tract infection, bronchitis, pneumonia, bacillary dysentery, enteritis, urinary system infection, septicemia and other multi-infections." Kunming conventional medical herbs among the people " carries, " stomach invigorating, pain relieving, antiinflammatory, hemostasis.Control abdominal distention, dysentery, hepatitis, prostatitis, traumatic hemorrhage.”
Pericarpium Lagenariae sicerariae: sweet in the mouth, light, property is put down; Return lung, spleen, kidney channel.Inducing diuresis to remove edema, logical woods eliminating stagnation.Cure mainly edema, ascites, jaundice, quench one's thirst, gonorrhea, carbuncle." Luchuan book on Chinese herbal medicine " carries: " xeropulmonary cough is controlled in lung moistening.”
Fructus Momordicae: sweet in the mouth, cool in nature; Return lung, large intestine channel.Clearing heat and moistening lung, laxation relieving constipation.For lung-fire cough caused by dryness, pharyngalgia aphonia, dryness of the intestine constipation." Guangxi Chinese medicinal herbal " carries: " cough-relieving heat clearing away, removing heat from blood intestine moistening.Control cough, the dry gastric heat constipation of blood etc.”
Folium Callicarpae Formosanae: bitter and puckery flavor, cool in nature.Astringing to arrest bleeding, heat-clearing and toxic substances removing.Cure mainly upper respiratory tract infection, tonsillitis, pneumonia, bronchitis; Traumatic hemorrhage is controlled in external, burn." illustrated handbook planted by middle traditional Chinese medicines " carries, and " hemorrhage to esophageal vein, intestine gastric ulcer is hemorrhage, epistaxis, wound hemorrhage, pneumorrhagia and have tooth pulled out and hemorrhagely all have good effect.”
Herba Sonchi Oleracei: bitter in the mouth, cold in nature; Enter the heart, spleen, stomach three warp.Heat-clearing and toxic substances removing, removing blood stasis with potent drugs is invigorated blood circulation, evacuation of pus.For appendicitis, peritoneal abscess, enteritis, dysentery, acute and chronic pelvic inflammatory disease, cough due to lung-heat, pulmonary tuberculosis, spits blood, epistaxis; Traumatic injury is controlled in external, and furuncle swells and ache, impetigo, eczema scrotum.
Fructus Forsythiae: bitter in the mouth, cold nature; Return lung, the heart, gallbladder meridian.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, dispelling wind and heat pathogens.Cure mainly carbuncle sore tumefacting virus, sucutaneous nodule scrofula, affection due to external wind and heat, epidemic febrile disease is from the beginning of, puckery pain of pyretic stranguria etc." herbal classic " carries: " main cold and heat, Mus flaccidity, scrofula, carbuncle malignant boil, goiter, stagnation of pathogenic heat." modern medicine study confirmation, Fructus Forsythiae concentrated decotion has antibacterial action in vitro, can suppress Bacillus typhi, Salmonella paratyphi, escherichia coli, dysentery bacterium, diphtheria corynebacterium and vibrio cholera, staphylococcus, streptococcus etc.
Rhizoma Nelumbinis: sweet in the mouth, cool in nature.Clearing away heat and promoting production of body fluid, cooling blood for hemostasis, dissipating blood stasis blood, QI invigorating of reposing." traditional Chinese medical science " carries: " repose, physical strength profiting." modern medicine study confirmation, the nutritive value of Rhizoma Nelumbinis is very high, is rich in the trace element such as ferrum, calcium, and phytoprotein, vitamin and content of starch are also very abundant, has obvious benefiting vital QI and blood, strengthens the effect of body immunity.
Caulis Trachelospermi: bitter in the mouth, cold nature; GUIXIN, liver, kidney channel.Dispelling wind and removing obstruction in the collateral, removing heat from blood is subsided a swelling.For beriberoid pyretic arthralgia, the contracture of muscle arteries and veins, soreness of waist and knee joint, sore throat, carbuncle, injury from falling down.Modern medicine study confirms, Caulis Trachelospermi 50% decoct has inhibitory action to staphylococcus aureus, shigella flexneri and Bacillus typhi.
Radix Tinosporae: bitter in the mouth, cold in nature; Return lung, large intestine channel.Heat-clearing and toxic substances removing.Treating acute and chronic tonsillitis, acute pharyngolaryngitis, stomatitis, parotitis, mastitis, appendicitis, carbuncle furuncle, acute chronic enteritis, bacillary dysentery, stomachache, cough due to heat aphonia." property of medicine is examined " carries: " removing toxic substances, throat numbness is anxious, and erosion of mucous membrane of the oral cavity should take, the red furuncle Skin-disease of cellulitis carbuncle carbuncle on the back , inflammation, snakes and scorpions insect bite, and mill is coated with, and control ophthalmalgia, bulge of the ear, cough due to heat, haze miasma, tells nosebleed, all outer diseases.”
Northern bedstraw: bitter in the mouth, cold in nature.Heat-clearing and toxic substances removing, expelling wind and activating blood circulation.Cure mainly pneumonia cough, oedema due to nephritis, lumbago and skelalgia, women's amenorrhea, dysmenorrhea, leukorrhagia, skin ulcer tinea.
Lignum et Radix Naucleae: bitter in the mouth, cold in nature; Return lung, large intestine, gallbladder, urinary bladder channel.Heat-clearing and toxic substances removing, reducing swelling and alleviating pain.Cure mainly cold, fever, bronchitis, pneumonia, acute tonsillitis, pharyngolaryngitis, mastitis, enteritis, bacillary dysentery, urinary tract infection, cholecystitis, ulcer of the lower limb, tinea pedis infects, furuncle and phyma pus infections, dermatitis and eczema.
Herba Asari Forbesii: acrid in the mouth, warm in nature, mild toxicity; Return lung, liver, kidney, urinary bladder channel.Expelling wind and cold, expectorant diuretic, promoting blood circulation and stopping pain.Cure mainly anemofrigid cold, phlegm retention is breathed with cough, edema, anemofrigid-damp arthralgia, traumatic injury, headache, toothache, stomachache, and eruptive disease is suffered from abdominal pain, scrofula, toxic swelling, venom." Jiangsu medical material will " carries: " diaphoresis is eliminated the phlegm.Cure cold headache, toothache, aphtha of the mouth and tongue.”
Semen Raphani: acrid in the mouth, sweet, property is put down; Return lung, spleen, stomach warp.Help digestion de-swelling, lowering the adverse-rising QI to resolve phlegm.For retention of food and drink, abdominal distention, constipation, stagnant dysentery, expectorant heap soil or fertilizer over and around the roots is breathed with cough." detailed outline " carries: " therapeutic method to keep the adverse QI flowing downwards Dingchuan, controls expectorant, helps digestion, de-swelling, sharp defecation, only pain due to disorder of QI, heavy after dysentery, sends out skin ulcer rash.”
Semen Ginkgo: sweet in the mouth, bitterness, property is put down, slightly poisonous; Enter lung, kidney channel.Astringe the lung gas, relieving asthma and cough, leukorrhagia stopping is turbid, urine reducing, disinfection.Cure mainly asthma, phlegmatic cough, nocturnal emission, leucorrhea, nebulousurine, infantile diarrhea, malnutrition due to parasitic infestation, hemorrhoidal hamorrhage dysentery, gonorrhea, frequent micturition, and the disease such as scabies, dermatitis rhus, in vain tumor wind." herbal classic meets source " carries: " Semen Ginkgo has the function of falling expectorant, detoxicating, parasite killing, can treat " skin ulcer scabies cellulitis tumor, acute mastitis are festered, tooth worm dental caries, infantile diarrhea, leucorrhea with red and white discharge, chronic stranguria with turbid discharge, disease such as the seminal emission enuresis etc." the experiment proved that Semen Ginkgo has antibacterial and bactericidal action, can be used for treating respiratory tract infectious disease.Gingkgo water preserved material has inhibitory action in various degree to various fungus, can antipruritic treatment tinea.
The present invention compared with prior art, has following beneficial effect:
Chinese medicine preparation of the present invention selects rare Chinese medicine scientific composition; there is effect of benefiting qi and removing blood stasis, heat-clearing and toxic substances removing; immunity of organism resistance can be improved while the growth of inhibition tumor cell; promote the phagocytic function of macrophage; increase leucocyte content; protection hemopoietic function of bone marrow; improve patient's ill symptoms and sign; be mainly used in the treatment of the tumors such as lung tumors, breast carcinoma, gastric cancer; also can be used for the postoperative adjuvant therapy of above-mentioned cancer; antitumor action is obvious, and safe without toxic side effect is an important breakthrough of oncotherapy.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
The raw material composition of Chinese medicine preparation effective ingredient of the present invention and weight are:
The preparation method of Chinese medicine preparation of the present invention, comprises following processing step:
(1) Pericarpium Pyri, Fructus Momordicae, Fructus Forsythiae, northern bedstraw, Lignum et Radix Naucleae and Semen Raphani are cleaned, put into container, add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate, for subsequent use;
(2) Folium et Ramulus Callicarpae nudiflorae, Folium Callicarpae Formosanae, Caulis Trachelospermi and Herba Asari Forbesii are cleaned, immerse the alcohol solution dipping 1 ~ 2 hour of 70% of 3 times amount, heating extraction 3 hours, reclaim ethanol, filter, at simmer down to 65 DEG C, relative density is the thick paste of 1.10 ~ 1.12, for subsequent use;
(3) after Radix Hemsleyae Macrospermae, Pericarpium Lagenariae sicerariae, Radix Tinosporae and Semen Ginkgo decontamination being cleaned, dry, be placed in mortar and grind into powder, cross 160 order fine powders, for subsequent use;
(4) Herba Sonchi Oleracei and Rhizoma Nelumbinis decontamination are cleaned, put into container, rub with agitator, filter impurity, stays juice for subsequent use;
(5) by the filtrate obtained by above-mentioned steps (1) ~ (4), thick paste, fine powder and juice mixing, make capsule, be the Chinese medicine preparation for the treatment of lung tumors of the present invention.
Usage and dosage: oral, every day 2 times, each 1 time sooner or later, each 3, warm water delivery service after meal; Within 10 days, be 1 course for the treatment of, 2 ~ 3 courses for the treatment of can cure, and the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
Embodiment 2
The raw material composition of Chinese medicine preparation effective ingredient of the present invention and weight are:
The Chinese medicine preparation preparation method processing step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 3
The raw material composition of Chinese medicine preparation effective ingredient of the present invention and weight are:
The Chinese medicine preparation preparation method processing step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 4
The raw material composition of Chinese medicine preparation effective ingredient of the present invention and weight are:
The Chinese medicine preparation preparation method processing step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 5
The raw material composition of Chinese medicine preparation effective ingredient of the present invention and weight are:
The Chinese medicine preparation preparation method processing step of the present embodiment and usage and dosage identical with embodiment 1.
Clinical data:
1, case selection:
As the Chinese medicine preparation for the treatment of lung tumors, select the routine clinical observation of lung tumors patient 200 of making a definite diagnosis, patient is divided into treatment group and matched group two groups at random, treatment group 100 example, wherein male 59 example, women 41 example, 47 ~ 65 years old age, 56.3 years old mean age, the shortest person of the course of disease 6 months, most elder 5 years, average 2.5 years.Matched group 100 example, wherein male 58 example, women 42 example, 48 ~ 66 years old age, 55.3 years old mean age, the shortest person of the course of disease 5 months, most elder 6 years, average 3.1 years.
The course of disease, the degrees of symptoms for the treatment of group and matched group two groups of cases are basically identical, without significant difference, have comparability.
2, medicament selection:
Treatment group takes Chinese medicine preparation of the present invention, oral, every day 2 times, each 1 time sooner or later, each 3, warm water delivery service after meal; Within 10 days, be 1 course for the treatment of, take 2 ~ 3 courses for the treatment of continuously, the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
Matched group uses cyclophosphamide Injection, and each 500 ~ 1000mg/m2,1 time weekly, is used in conjunction 2 times; Within 30 days, be 1 course for the treatment of, take 2 ~ 3 courses for the treatment of continuously, the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
3, efficacy determination:
(1) cure: cough, spitting of blood, the pain over the chest and back, stridulate and the transference cures such as agnogenic heating, CT check display pulmonary is without lump, and health various functions is all normal.
(2) take a turn for the better: above-mentioned symptom turns for the better by and large, and patient's body's immunity recovers to some extent.
(3) invalid: after taking medicine, clinical symptoms is without obvious change.
4, result:
Select in the treatment group of Chinese medicine preparation of the present invention, cure 61 examples, take a turn for the better 34 examples, invalid 5 examples, cure rate 61%, total effective rate 95%.
Cure 34 examples in matched group, take a turn for the better 28 examples, invalid 38 examples, cure rate 34%, total effective rate 62%.
Above result display, the cure rate for the treatment of group and total effective rate are apparently higher than matched group.
Model case is illustrated:
1, high certain, man, 54 years old, coal miner, Yuncheng, Shanxi people.Patient, for a long time in underground coal mine work, often feels that chest is uncomfortable, after to increase the weight of gradually and with cough, spitting of blood, the pain over the chest and back, stridulate and agnogenic heating etc., admission examination is diagnosed as central type carcinoma of lung, and forming a large amount of hydrothorax, to cause left shoulder arm to ache unbearably painful.Hospital's suggestion operation and chemotherapeutic treatment, because this patient's economic condition is bad, perform the operation and hugely make patient anxious, start to take Chinese medicine preparation of the present invention by a traditional Chinese medical science introduction, after taking 2 courses for the treatment of, patient feels that self symptom disappears substantially, passive protective physical fitness obviously strengthens, continue to take a course for the treatment of, CT check display pulmonary masses disappears completely, follows up a case by regular visits to and does not recur so far.
2, certain is congratulated, female, 60 years old, peasant, From Shandong Rizhao people.Patient does routine physical examination and finds that right lung has about 5mm lump, and chest was once by microtrauma at that time, went to hospital to do antiinflammatory process, check its lump after three months and expand 27mm to, biopsy is small cell carcinoma of lung, takes Chinese medicine preparation of the present invention, after taking 1 course for the treatment of, pulmonary's pain obviously alleviates; After continuing to take 2 courses for the treatment of, CT check display pulmonary masses disappears completely.