CN103784797A - Traditional Chinese medicine for treating chronic lymphocytic leukemia - Google Patents

Abstract

The invention relates to the field of medicinal formulations, particularly relates to a traditional Chinese medicine for treating chronic lymphocytic leukemia, which is characterized in that the traditional Chinese medicine comprises the following raw materials in percentage by weight: 6-9% of Artemisia capillaris, 11-14% of Platycladus orientalis leaf, 10-13% of Akebia quinata, 4-6% of Agrimonia pilosa, 5-8% of Resina Taxicodendri, 1-2% of Pinellia ternate, 6-8% of Dioscorea bulbifera, 4-7% of Rhizoma Chuanxiong, 2-4% of Lonmicera japonica stem, 3-5% of Placenta Hominis, 2-5% of Galium paradoxum, 2-4% of Ligustrum lucidum fruit, 3-5% of blighted wheat, 2-4% of Iris lactea seed, 3-5% of Taraxacum mongolicum, 5-7% of Asparagus cochinchinensis, 6-9% of Paeonia suffruticosa bark, and 2-4% of Rhizoma Polygonati. The preparation method includes the steps of grinding Placenta Hominis into fine powder, soaking the rest raw materials in water, decocting, filtering, removing residue, collecting filtrate, and adding Placenta Hominis fine powder into the filtrate. The traditional Chinese medicine has low cost, high therapeutic effect on chronic lymphocytic leukemia, and no toxic or adverse effect, and has effects of strengthening body resistance, nourishing yin, tonifying yang, invigorating qi, promoting blood circulation, tonifying kidneys, replenishing essence, strengthening the spleen, nourishing the stomach, softening hardness, eliminating stagnation, smoothing collaterals and relieving pain.

Description

The Chinese medicine for the treatment of chronic lymphocytic leukemia

Technical field

The present invention relates to a kind of Chinese patent medicine preparation, specifically a kind of Chinese medicine that is used for the treatment of chronic lymphocytic leukemia.

Background technology

As everyone knows, leukemia is the malignant clone disease of a class hematopoietic stem cell, because leukaemia's self renewal strengthens, proliferation out of control, dysdifferentiation, apoptosis is obstructed, and be stuck in cytocerastic different phase, in bone marrow and other hemopoietic tissue, a large amount of hypertrophy accumulations of leukaemia, make normal hematopoiesis suppressed and infiltrate other Organ and tissues.According to leukaemia's maturity and natural history, leukemia is divided into acute and chronic two large classes.Chronic lymphocytic leukemia is a kind of monoclonicity small lymphocyte disease; cell is normally or higher than normal speed to copy propagation; accumulate in a large number bone marrow, blood, lymph node and other organs, finally cause the low potential malignancy disease of normal hematopoiesis nonfunction.Similar mature lymphocyte in this class cellular morphology, but jejune, the Insufficient cell of a kind of immunology.This disease major part is more than 50 years old old people, and early symptom can have tired, then occurs loss of appetite, becomes thin, heating, night sweat etc.Most of patient has lymphadenectasis, mild to moderate splenomegaly, and slight hepatomegaly, breastbone tenderness is rare, and patients with terminal hemopoietic function of bone marrow is impaired, can occur anemia, thrombocytopenia and granulocytopenia.Due to immunocyte decline, normal easily accompanying infection.Also often there is autoimmune phenomena, autoimmune hemolytic anemia, immunologic thrombocytopenic purpura, can there is prolymphocytic leukemia syndrome etc. in whole latter stage, become the dangerous property of the one disease of serious threat people life and health.This disease Therapeutic Method is from start to finish exactly chemoimmunotherapy, but chemotherapy again and again can only the respite state of an illness, and hematological alleviation in other words conj.or perhaps can not long-term remission, more can not cure, and large absolutely number can recurrence.When chemotherapy is killed and wounded leukaemia, the normal hemopoietic system cell of health is had to injury effect, also other important organs of health are caused to damage.Chemotherapy course for the treatment of must RMB several thousand yuan to two, 30,000 yuan, generally need several even tens courses for the treatment of, patient's immunity is also day by day low, infects, complication increases, and brought great financial burden and psychic pain to patient.

Summary of the invention

Technical problem to be solved by this invention is in order to overcome the deficiencies in the prior art, and a kind of Chinese medicine for the treatment of chronic lymphocytic leukemia is provided, and cost is low, treatment chronic lymphocytic leukemia curative effect is high, have no side effect, there is the body resistance strengthening and constitution consolidating, nourishing YIN and invigorating YANG, QI invigorating and blood producing, kidney tonifying, essence replenishing, strengthening the spleen and nourishing the stomach, hard masses softening and resolving, effect of removing obstruction in the collateral to relieve pain, in being applicable to, late period chronic lymphocytic leukemia.

The technical scheme that the present invention solves the problems of the technologies described above employing is: a kind of Chinese medicine for the treatment of chronic lymphocytic leukemia, it is characterized in that crude drug composition is by weight percentage: Herba Artemisiae Scopariae 6～9%, Cacumen Platycladi 11～14%, Caulis Akebiae 10～13%, Herba Agrimoniae 4～6%, Resina Toxicodendri 5～8%, Rhizoma Pinelliae 1～2%, Pseudobulbus cremastrae seu pleiones 6～8%, Rhizoma Chuanxiong 4～7%, Caulis Lonicerae 2～4%, Placenta Hominis 3～5%, Herba Galii Teneri 2～5%, Fructus Ligustri Lucidi 2～4%, Fructus Tritici Levis 3～5%, Semen Iridis 2～4%, Herba Taraxaci 3～5%, Radix Asparagi 5～7%, Cortex Moutan 6～9%, Rhizoma Polygonati Odorati 2～4%, Placenta Hominis is worn into smalls for subsequent use, again 17 taste crude drug of remainder are soaked in water, the filtrate of removing slag after decocting to obtain, in the most backward filtrate, add Placenta Hominis smalls.

The invention has the beneficial effects as follows, cost is low, and treatment chronic lymphocytic leukemia curative effect is high, has no side effect, there is the body resistance strengthening and constitution consolidating, nourishing YIN and invigorating YANG, QI invigorating and blood producing, kidney tonifying, essence replenishing, strengthening the spleen and nourishing the stomach, hard masses softening and resolving, removing obstruction in the collateral to relieve pain effect, in being applicable to, late period chronic lymphocytic leukemia.

The specific embodiment

Below in conjunction with embodiment, the invention will be further described:

Embodiment 1:

Adopting Herba Artemisiae Scopariae, Cacumen Platycladi, Caulis Akebiae, Herba Agrimoniae, Resina Toxicodendri, Rhizoma Pinelliae, Pseudobulbus cremastrae seu pleiones, Rhizoma Chuanxiong, Caulis Lonicerae, Placenta Hominis, Herba Galii Teneri, Fructus Ligustri Lucidi, Fructus Tritici Levis, Semen Iridis, Herba Taraxaci, Radix Asparagi, Cortex Moutan, Rhizoma Polygonati Odorati is that crude drug is prepared from.Every pair of its component (% by weight) is Herba Artemisiae Scopariae 8, Cacumen Platycladi 13, Caulis Akebiae 12, Herba Agrimoniae 6, Resina Toxicodendri 7, Rhizoma Pinelliae 2, Pseudobulbus cremastrae seu pleiones 7, Rhizoma Chuanxiong 5, Caulis Lonicerae 4, Placenta Hominis 4, Herba Galii Teneri 5, Fructus Ligustri Lucidi 3, Fructus Tritici Levis 3, Semen Iridis 3, Herba Taraxaci 4, Radix Asparagi 5, Cortex Moutan 6, Rhizoma Polygonati Odorati 3.Getting above-mentioned 18 taste crude drug gross weights is 197 grams, first Placenta Hominis is worn into smalls for subsequent use, then 17 taste crude drug of remainder are added water about 1000ml, soak 4～5 hours, boil rear slow fire and decoct 80～90 minutes, the filtrate 200ml left and right of removing slag to obtain, medicinal residues 200～the 300ml that adds water again, decoct 30～40 minutes, remove slag and to obtain filtrate 100ml left and right, be total to obtain 300ml left and right medicine juice, make decoction, in the most backward decoction, add Placenta Hominis smalls, pack in aseptic vial, seal bottle cap is for subsequent use.1 dose point of every day 2 times is oral, each (medicine) being taken before meal 150ml left and right, and when oral decoction of the present invention, then white bladder in fit applications Hemerocallis citrina Baroni fish maw, Hemerocallis citrina Baroni roe bladder is dried, pulverization, every day 3 times, 5 grams of each taking medicine before meal, with yellow wine, 10ml takes after mixing it with water.It is a course for the treatment of that oral decoction of the present invention coordinates Hemerocallis citrina Baroni roe bladder yellow wine to take after mixing it with water 30 days, has a rest and carries out next course for the treatment of for one week again, generally applies four courses for the treatment of.

Herba Artemisiae Scopariae clearing away heat-damp and promoting diuresis of the present invention, jaundice eliminating.Cure mainly: jaundice, dysuria, eczema pruritus etc.Pharmaceutical research has function of gallbladder promoting, and liver function protecting is antipyretic, antiinflammatory, blood fat reducing, blood pressure lowering; Cacumen Platycladi removing heat from blood, hemostasis, wind-damp dispelling, loose toxic swelling.Control haematemesis, epistaxis, hematuria, dysentery, hemorrhoidal hamorrhage, metrorrhagia, rheumatic arthralgia, bacillary dysentery, hypertension, cough, erysipelas, mumps, scalds; Caulis Akebiae nature and flavor hardship, cool.Pathogenic fire purging row water, promoting blood circulation.Cure mainly hot urination, stranguria with turbid discharge, edema, irritable feverish sensation in the chest, sore throat pharyngalgia, inflexible pain all over, women's amenorrhea, galactostasis; Herba Agrimoniae energy astringing to arrest bleeding, dysentery relieving, parasite killing.Be widely used in various hemorrhage cards, for example: haematemesis, hematuria, have blood in stool, metrorrhagia, spitting of blood, epistaxis, dysentery, impairment caused by overstrain takes off power, carbuncle, traumatic injury, the diseases such as wound hemorrhage; Resina Toxicodendri nature and flavor: pungent, temperature, poisonous.Gui Jing: return liver, spleen channel.Effect: removing blood stasis with potent drugs blood, removing food stagnancy, parasite killing.Cure mainly: for women's amenorrhea, blood stasis lump in the abdomen, abdominal pain due to worm stagnation; Rhizoma Pinelliae drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.Control damp-phlegm cold drink, vomiting, regurgitation, cough with asthma abundant expectoration, chest and diaphragm distension, syncope due to accumulation of phlegm headache; The disappear expectorant of cloudy point of Pseudobulbus cremastrae seu pleiones, cough-relieving is coughed, and controls sore throat, only throat pain.Control skin infection, attack carbuncle, apply all pyogenic infections from tumour or sore, person bursts pus, and no pus person disappear; Rhizoma Chuanxiong is for pain in chest and hypochondrium, rheumatic arthralgia, lump in the abdomen caking, skin infection swells and ache, fall and flutter the pain of injury, menoxenia, amenorrhea dysmenorrhea, puerperal the disease such as stasis of blood pain; Caulis Lonicerae is controlled epidemic febrile disease heating, toxic-heat and blood stasis, infectious hepatitis, carbuncle sore tumefacting virus, bones and muscles pain; Placenta Hominis is warm in nature, hide sweet, salty, have the kidney warming mend essence, effect of benefiting QI and nourishing blood, clinically for asthenia win thin, hectic fever due to YIN-deficiency night sweat, cough and asthma, lack of appetite is breathed hard, impotence and seminal emission, infertile hypogalactia; Herba Galii Teneri cures mainly urinary system infection, edema, gingival hemorrhage, metrorrhagia, dysmenorrhea, leucorrhea, cancer, leukemia, appendicitis; Fructus Ligustri Lucidi is for the poor vision of the hepatic and renal YIN deficiency, visual deterioration, early whitening of beard and hair, soreness of waist tinnitus and fever due to yin deficiency etc.; Fructus Tritici Levis QI invigorating heat extraction, only spontaneous sweating, hectic fever due to YIN-deficiency deficiency-heat, married woman's consumptive fever.Reinforcing the heart, only tired, heat extraction, arresting sweating, diuresis; Semen Iridis heat clearing away, dampness removing, hemostasis, removing toxic substances.The subcutaneous ulcer of harnessing the Yellow River, dysentery, spits blood, epistaxis, metrorrhagia, leucorrhea, sore throat, carbuncle; Herba Taraxaci nature and flavor are sweet, bitter, cold, have heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, antiinflammatory, removing heat from blood, diuresis, function of gallbladder promoting, hypocatharsis, stomach invigorating; Radix Asparagi has replenishing YIN and removing heat, effect of lung moistening nourishing kidney.Be used for controlling fever due to yin deficiency, cough haematemesis, lung abscess, laryngopharynx swelling and pain, quench one's thirst; Cortex Moutan cold nature, bitter in the mouth is pungent, nontoxic.Enter the heart, liver, kidney channel.Have and purify the blood, the function of promoting blood circulation to remove blood stasis.Cure mainly macule and spit blood, amenorrhea due to stagnation of blood, premenstrual gesture, carbuncle sore tumefacting virus, traumatic blood stasis, the deficiency of YIN is sent out gesture, lossless; Rhizoma Polygonati Odorati nourishing YIN and moistening the lung, nourishing the stomach to promote the production of body fluid.Cough caused by dryness, chronic cough, the dry throat and mouth of the cloudy liquid consumption of calentura wound, interior-heat is quenched one's thirst, and deficiency of YIN diseases caused by exogenous pathogenic factor are dizzy dizzy, muscle arteries and veins spasm and pain.The ingenious prescription of 18 taste Chinese herbal medicine, science compatibility, the mutual coordinative role of medicine, reaches the body resistance strengthening and constitution consolidating, nourishing YIN and invigorating YANG, QI invigorating and blood producing, kidney tonifying, essence replenishing, strengthening the spleen and nourishing the stomach, hard masses softening and resolving, removing obstruction in the collateral to relieve pain effect, centering, late period, chronic lymphocytic leukemia was all effective.Fit applications Hemerocallis citrina Baroni roe bladder dries smalls, and yellow wine is taken after mixing it with water, and has strongly invigorating primordial QI, and QI and blood regulating effect is played the specially good effect of chronic lymphocytic leukemia altogether.

The embodiment that the each raw material of the present invention also can the listed ratio of according to the form below (percentage by weight) mixes realizes.Its processing technique is identical with embodiment 1.

The clinical trial of carrying out below in conjunction with my institute is done further, is described in detail the present invention:

1, case selection: selected case is the diagnosis and treatment of Lai Wo institute, in conjunction with clinical manifestation, in peripheral blood, persistence monoclonicity lymphocyte is greater than 5 × 10 ⁹/ L, small lymphocyte>=40% in bone marrow, and according to immunology surface marker, its diagnosis all meets " internal medicine " the 7th edition chronic lymphocytic leukemia diagnostic criteria of Lu Zaiying, Zhong Nanshan chief editor, selected case 61 examples, male 39 examples, female's 22 examples; 49～69 years old age, 64 years old mean age; Mid-terms 37 example, late periods 24 example.

2, Therapeutic Method: 1 dose point of every day 2 times is oral, and each (medicine) being taken before meal 150ml left and right, when oral decoction of the present invention, white bladder in fit applications Hemerocallis citrina Baroni fish maw again, dries Hemerocallis citrina Baroni roe bladder pulverization, every day 3 times, 5 grams of each taking medicine before meal, with yellow wine, 10ml takes after mixing it with water.It is a course for the treatment of that oral decoction of the present invention coordinates Hemerocallis citrina Baroni roe bladder yellow wine to take after mixing it with water 30 days, has a rest and carries out next course for the treatment of for one week again, applies four courses for the treatment of.

3, the standard of curative effect evaluation:

Alleviate completely: treat four courses for the treatment of, patients with chronic lymphocytic clinical symptoms sign all disappears, in peripheral blood, persistence monoclonicity lymphocyte disappears, and in bone marrow, small lymphocyte disappears, crucial immunological abnormality marks obliterated.

Partial rcsponse: treat four courses for the treatment of, patients with chronic lymphocytic clinical symptoms sign part disappears, and in peripheral blood, persistence monoclonicity lymphocyte is less than 5 × 10 ⁹/ L, in bone marrow, small lymphocyte is less than 40%, and crucial immunological abnormality mark part disappears.

Invalid: treat four courses for the treatment of, patients with chronic lymphocytic clinical symptoms sign is without change, and in peripheral blood, persistence monoclonicity lymphocyte is still greater than 5 × 10 ⁹/ L, in bone marrow, still>=40%, crucial immunological abnormality mark is without change for small lymphocyte.

4, therapeutic effect: use the present invention's 61 examples, treat four courses for the treatment of, carry out treatment effectiveness evaluation according to the standard of curative effect evaluation: alleviate 42 examples completely, partial rcsponse 13 examples, invalid 6 examples, total effective rate is 90.2%.

Claims (1)

1. treat the Chinese medicine of chronic lymphocytic leukemia for one kind, it is characterized in that: Herba Artemisiae Scopariae 6～9%, Cacumen Platycladi 11～14%, Caulis Akebiae 10～13%, Herba Agrimoniae 4～6%, Resina Toxicodendri 5～8%, Rhizoma Pinelliae 1～2%, Pseudobulbus cremastrae seu pleiones 6～8%, Rhizoma Chuanxiong 4～7%, Caulis Lonicerae 2～4%, Placenta Hominis 3～5%, Herba Galii Teneri 2～5%, Fructus Ligustri Lucidi 2～4%, Fructus Tritici Levis 3～5%, Semen Iridis 2～4%, Herba Taraxaci 3～5%, Radix Asparagi 5～7%, Cortex Moutan 6～9%, Rhizoma Polygonati Odorati 2～4%, Placenta Hominis is worn into smalls for subsequent use, again 17 taste crude drug of remainder are soaked in water, the filtrate of removing slag after decocting to obtain, in the most backward filtrate, add Placenta Hominis smalls.