CN104225340A - Drug for treating leukaemia and preparation method - Google Patents

Drug for treating leukaemia and preparation method Download PDF

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CN104225340A
CN104225340A CN201410522616.5A CN201410522616A CN104225340A CN 104225340 A CN104225340 A CN 104225340A CN 201410522616 A CN201410522616 A CN 201410522616A CN 104225340 A CN104225340 A CN 104225340A
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herba
fructus
folium
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于仁斌
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于仁斌
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Abstract

The invention discloses a drug for treating leukaemia and a preparation method and belongs to the field of traditional Chinese medicine. The drug comprises effective components from raw materials of leaves of Japanese banana, seman platycladi, wormseed mustard, hellebore, melodinus suaveolens champ, cladonia stellaris, twoleaf swertia herb, lantana camara, Chinese buckeye seed, rigidleaf cymbidium stems and leaves, virgate wormwood herb, stigma maydis, sampson St.John's wort, milkwort roots, falsesour cherry leaves, and common camptotheca fruit. According to the drug for treating leukaemia and the preparation method, selected medicinal materials are appropriately compatible and meet theories of traditional Chinese medicine and pharmacy and modern medicine and pharmacology, the drug has effects of benefiting qi and nourishing blood, soothing liver-qi stagnation, relieving swelling and pain, and tonifying the kidney and the spleen, human immunity and hematopoietic stem cell mechanisms are improved by improving human physiological functions, obvious and fast curative effects of treating leukaemia are achieved, a treatment course is short, any toxic and side effects are absent, and the drug is convenient to take, low in price and worth being clinically popularized and applied.

Description

One treats leukemic medicine and preparation method
Art
The present invention relates to the field of Chinese medicines, particularly relate to one and treat leukemic medicine and preparation method.
Background technology
Leukemia is a class hematopoietic stem cell malignant clone disease.Clonal leukaemia breeds accumulation in a large number because of mechanism such as proliferation out of control, dysdifferentiation, apoptosis are obstructed in bone marrow and other hemopoietic tissue, and infiltrates other tissue and organ, and normal hematopoiesis is suppressed simultaneously.Clinical visible anemia in various degree, hemorrhage, infectious fever and liver, spleen, lymphadenectasis and skeleton pain, according to reports, the leukemic sickness rate in China each department accounts for the 6th in various tumor, leukemia can be divided into by the emergency of onset, acute leukemia cells differentiation is stuck in commitment, based on original and prorubricyte, disease progression is rapid, the course of disease several months; Chronic leukemia cell differentiation is better, and based on inmature or mature cell, slower development, the course of disease several years, by sick cell series classification, comprises the grain of medullary system, the T of single, red, macronucleus system and lymphatic system and B cell system; Normal clinically leukemia is divided into acute lymphoblastic leukemia, acute myelocytic leukemia, chronic myelocytic leukemia, chronic lymphocytic leukemia etc.
Above-mentioned symptom can occur in early days in leukemia, minority case can before making a definite diagnosis several months or several years first there is myelodysplastic syndrome MDS, later developing deeply becomes leukemia.Patient often with weak, pale complexion, cardiopalmus, breathe hard, the symptom such as lower limbs edema.
Due to leukemia classification and prognosis layering complexity, so there is no machine-made Therapeutic Method, need to formulate therapeutic scheme in conjunction with careful typing and prognosis layering.Mainly contain following a few class Therapeutic Method at present: Hua Zhi Liao ﹑ Fang penetrates Zhi Liao ﹑ targeted therapy, immunization therapy, stem cell transplantation etc.By rational comprehensive therapy, leukemic prognosis is taken on a new look greatly, and considerable patient can obtain and cure or long-term stability, and leukemia has been pass by the epoch of " incurable disease ".
At present, although treat leukemic medicine a lot, mostly curative effect is general, and subject range is little, and expensive.In recent years, domestic Chinese patent medicine increased, but due to its formula dull, unreasonable, still there is function singleness, the defect of therapeutic effect difference.So, people still crave for have that a kind of cost is low, taking convenience and the significant medicine of therapeutic effect come out.
Summary of the invention
The invention provides one and treat leukemic medicine and preparation method; Selected by medicine of the present invention, medical material compatibility is suitable, meet Chinese medicine and pharmacy and modern medicine theory, and there is benefiting qi and nourishing blood, effect that dispersing the stagnated live-QI to relieve the stagnation of QI, reducing swelling and alleviating pain, kidney tonifying help spleen, by improving human physiological functions, improve human immunity and hematopoietic stem cell function, to leukemic treatment, there is significant curative effect, short treating period, instant effect, taking convenience, without any side effects, cheap, wide popularization and application on clinic.
For achieving the above object, technical scheme of the present invention is implemented as follows:
One treats leukemic medicine, and raw material composition and the parts by weight of making described effective ingredient are:
Raw material composition and the parts by weight of making described effective ingredient are:
Raw material composition and the parts by weight of making described effective ingredient are:
Raw material composition and the parts by weight of making described effective ingredient are:
Treat a preparation method for leukemic medicine, comprise following processing step:
(1) Folium Musae, Herba Erysimi Cheiranthoidis, Folium Lantanae Camarae and Semen Aesculi are put into container, carry out pulverization process, grind into powder, cross 180 order fine powders, for subsequent use;
(2) Semen Platycladi, Radix Chimonanthi praecocis and Folium Pruni pseudocerasi are cleaned, immerse the alcohol solution dipping 1 ~ 2 hour of 80% of 5 times amount, heating extraction 3 hours, reclaim ethanol, filter, obtain filtrate, at simmer down to 65 DEG C, relative density is the thick paste of 1.12 ~ 1.16, for subsequent use;
(3) Fructus Melodini Suaveolentis and Herba Artemisiae Scopariae are cleaned, chopping, puts into container, strand juice, and filter impurity, stays juice for subsequent use;
(4) Cladonia alpestris (L.) Rabenh., Herba Swertiae heteranthae, Herba Cymbidii Penduli, Stigma Maydis, Herba Hyperici Sampsonii, Radix Polygalae and Fructus seu radix camptothecae acuminatae (Fructus Camptothecae Acuminatae) are cleaned, put into container, add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate, being condensed into relative density at 60 DEG C is the thick paste of 1.10 ~ 1.13, for subsequent use;
(5) by thick paste, juice and the fine powder mixing obtained by above-mentioned steps (1) ~ (4), make tablet, obtain the leukemic medicine for the treatment of of the present invention.
The property of medicine of the present invention's Chinese medicine used is as follows:
Folium Musae: sweet in the mouth, light, cold in nature; GUIXIN, Liver Channel.Heat clearing away, diuresis, removing toxic substances.Control calentura, heatstroke, beriberi, carbuncle pyretic toxicity, scald." book on Chinese herbal medicine is new again " carries: " control heart-fire to burn, liver hot air wind producing, relieving restlessness expelling summer-heat.”
Semen Platycladi: sweet in the mouth, property is put down; GUIXIN, kidney, large intestine channel.Tranquilizing by nourishing the heart, hidroschesis intestine moistening.For fidgets due to deficiency insomnia, severe palpitation, night sweat due to yin deficiency, dryness of the intestine constipation." detailed outline " carries: " nourish heart gas, and profit kidney is dry, and Fructus Alpiniae Oxyphyllae is allayed excitement; Burn drop and control scabies.”
Herba Erysimi Cheiranthoidis: bitter in the mouth, pungent, cold in nature; Attach to the lung and stomach meridians.Invigorating the spleen and regulating the stomach, diuresis heart tonifying.Main incoordination between the spleen and stomach, accumulation of food in the stomach and intes tine due to indigestion, and the edema of heart failure." Chinese herbal medicine is commonly used in Tibet " carries: " clearing away heat from blood, antitussive, heart tonifying.Be in harmony empty infections heating, pulmonary tuberculosis cough, prolonged illness cardianeuria, can separate meat poisoning.”
Radix Chimonanthi praecocis: acrid in the mouth, warm in nature, poisonous; Return liver, lung meridian.Heat-clearing and toxic substances removing, promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain.For cystitis, urethritis, sore swollen toxin, traumatic injury." Guizhou side's medicine among the people collection " carries: " calm, antitussive, Zhichuan.Control traumatic injury, sore waist and aching in the waist and the back.”
Fructus Melodini Suaveolentis: bitter in the mouth, cool in nature.Promoting the circulation of QI to relieve pain, removing food stagnancy reduces phlegm.For dyspepsia, infantile malnutrition, orchitis, colicky, stomachache, cough with copious phlegm." Guangdong Chinese medicine " carries: " circulation of qi promoting, pain relieving.Control peratodynia, chest and diaphragm is glutted, lymphoid tuberculosis.”
Cladonia alpestris (L.) Rabenh.: lightly seasoned, property is put down; Return liver, stomach warp.Suppressing the hyperactive liver and subsiding YANG, regulating menstruation, hemostasis.For having a dizzy spell, hypertension, migraine, epistaxis, metrorrhagia, menoxenia, leucorrhea.
Herba Swertiae heteranthae: sweet in the mouth, micro-hardship, property is put down; GUIXIN, Liver Channel.Suppressing the hyperactive liver heart tonifying, nourishing blood for regulating menstruation.Dizzy for blood deficiency, neurasthenia, vascular hypertension, menoxenia.
Folium Lantanae Camarae: bitter in the mouth, micro-sweet, cool in nature, poisonous; Return large intestine channel.Heat clearing away, hemostasis.Main pulmonary tuberculosis spitting of blood, stomachache is vomited and diarrhoea, eczema, pudendal pruritus." Guangdong Chinese medicine " carries: " loose poison, applies large intestine infections carbuncle for dispelling wind for relieving itching, reducing swelling and alleviating pain.”
Semen Aesculi: sweet in the mouth, warm in nature; Return liver, stomach warp.Regulating the flow of QI to ease the stomach, and stomach and alleviating pain.Vexed for breast abdominal distention, gastralgia." detailed outline is picked up any lost article from the road " carries: " the inherited from one's ancestors side of Pueraria lobota, controls heart cold syndrome of the stomach pain, and worm pain, gastral cavilty liver diaphragm expands, infantile malnutrition malaria dysentery, haematemesis impairment caused by overstrain, flat stomach dredging collateral.”
Herba Cymbidii Penduli: sweet in the mouth, pungent, property is put down.Nourishing the lung to arrest cough, dissipating blood stasis regulating menstruation.For hemoptysis of pulmonary tuberculosis, bronchitis, pneumonia, breathes with cough, pharyngolaryngitis, menoxenia, leucorrhea." choosing of Simao, Yunnan Chinese herbal medicine " carries: " relieving cough and resolving phlegm, dissipating blood stasis for subsidence of swelling, hemostasis and anti-inflammation.Control pulmonary tuberculosis, pneumonia, tracheobronchitis, breath with cough, the fracture injury of tendon and muscle.”
Herba Artemisiae Scopariae: bitter in the mouth, pungent, cold nature; Return spleen, stomach, liver, gallbladder meridian.Heat clearing away, dampness removing, jaundice eliminating.Main jaundice, dysuria, eczema pruritus, infectious jaundice type hepatitis.Pharmaceutical research proves, Herba Artemisiae Scopariae has function of gallbladder promoting, the effect such as liver function protecting, antipyretic and anti-inflammatory, blood fat reducing blood pressure lowering, coronary dilating.
Stigma Maydis: sweet in the mouth, light, property is put down; Return bladder, liver, gallbladder meridian.Inducing diuresis to remove edema, suppressing the hyperactive liver function of gallbladder promoting.For acute and chronic nephritis, edema, acute hepatitis, chronic hepatitis, hypertension, diabetes, chronic sinusitis, lithangiuria, Biliary Calculi, the disease such as dysuria, damp and hot jaundice; And can habitual abortion be prevented." conventional glossary of Herbs and Drugs among the people " carries: " can reduce blood pressure, inducing diuresis to remove edema, controls nose bleeding, redly to collapse.”
Herba Hyperici Sampsonii: acrid in the mouth, hardship, cold in nature.Heat-clearing and toxic substances removing, dredge the meridian passage, cooling blood for hemostasis.For infantile hyperpyrexia, dysentery, enteritis, spits blood, epistaxis, menoxenia, leucorrhea; Traumatic hemorrhage is controlled in external, traumatic injury, mastitis, burn and scald, venom.
Radix Polygalae: bitter in the mouth, pungent, warm in nature; GUIXIN, kidney, lung meridian.To calm the nerves Fructus Alpiniae Oxyphyllae, eliminating phlegm for diminishing swelling.For the insomnia and dreamful sleep that disarmony between the heart and kidney causes, forgetful palpitation with fear, staring spells, expectoration is not well, sore swollen toxin, breast swell and pain." Mingyi Bielu " carries: " centering gas, spasmolytic is throbbed with fear, benefit essence, goes heat in heart intake of food in the morning and vomitting in the evening gas, skin, appearance yellow.”
Folium Pruni pseudocerasi: sweet in the mouth, hardship, warm in nature, nontoxic; Return liver, spleen, lung meridian.Warming middle-JIAO and strengthening the spleen, cough-relieving is stopped blooding, removing toxic substances parasite killing.Main cold syndrome of the stomach food stagnation, diarrhoea, cough, spits blood, and skin infection swells carbuncle, snake bite and insect sting, trichomonas vaginitis." book on Chinese herbal medicine is new again " carries: " nourishing the liver helps fire, spleen benefiting and stimulating the appetite, except the long-pending of gastral cavilty trembles with fear, helps digestion brokenly stagnant.”
Fructus seu radix camptothecae acuminatae (Fructus Camptothecae Acuminatae): bitter in the mouth, pungent, cold in nature, poisonous; Return spleen, stomach Liver Channel.Anticancer, heat clearing away, parasite killing.For gastric cancer, colon cancer, rectal cancer, bladder cancer, chronic myelocytic leukemia, acute lymphoblastic leukemia; Psoriasis is controlled in external." newly organized Chinese medicine summary " carries: " removing blood stasis, controls chronic lymphatic leukemia, chronic myelogenous leukemia has good therapeutic effect; Can only temporary relief of symptoms to acute leukemia.”
The present invention compared with prior art, has following beneficial effect:
Selected by medicine of the present invention, medical material compatibility is suitable, meet Chinese medicine and pharmacy and modern medicine theory, and there is benefiting qi and nourishing blood, effect that dispersing the stagnated live-QI to relieve the stagnation of QI, reducing swelling and alleviating pain, kidney tonifying help spleen, by improving human physiological functions, improve human immunity and hematopoietic stem cell function, to leukemic treatment, there is significant curative effect, short treating period, instant effect, taking convenience, without any side effects, cheap, wide popularization and application on clinic.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
The raw material composition of effective ingredient of the present invention and weight are:
Treat a preparation method for leukemic medicine, comprise following processing step:
(1) Folium Musae, Herba Erysimi Cheiranthoidis, Folium Lantanae Camarae and Semen Aesculi are put into container, carry out pulverization process, grind into powder, cross 180 order fine powders, for subsequent use;
(2) Semen Platycladi, Radix Chimonanthi praecocis and Folium Pruni pseudocerasi are cleaned, immerse the alcohol solution dipping 1 ~ 2 hour of 80% of 5 times amount, heating extraction 3 hours, reclaim ethanol, filter, obtain filtrate, at simmer down to 65 DEG C, relative density is the thick paste of 1.12 ~ 1.16, for subsequent use;
(3) Fructus Melodini Suaveolentis and Herba Artemisiae Scopariae are cleaned, chopping, puts into container, strand juice, and filter impurity, stays juice for subsequent use;
(4) Cladonia alpestris (L.) Rabenh., Herba Swertiae heteranthae, Herba Cymbidii Penduli, Stigma Maydis, Herba Hyperici Sampsonii, Radix Polygalae and Fructus seu radix camptothecae acuminatae (Fructus Camptothecae Acuminatae) are cleaned, put into container, add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate, being condensed into relative density at 60 DEG C is the thick paste of 1.10 ~ 1.13, for subsequent use;
(5) by thick paste, juice and the fine powder mixing obtained by above-mentioned steps (1) ~ (4), make tablet, obtain the leukemic medicine for the treatment of of the present invention.
Usage and dosage: oral, every day 2 times, each 1 time sooner or later, each 2 (every sheet 0.5g), warm water delivery service after meal; Within 18 days, be 1 course for the treatment of, 2 ~ 3 courses for the treatment of can fully recover, and the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
Embodiment 2
The raw material composition of effective ingredient of the present invention and weight are:
The process for preparing medicine processing step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 3
The raw material composition of effective ingredient of the present invention and weight are:
The process for preparing medicine processing step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 4
The raw material composition of effective ingredient of the present invention and weight are:
The process for preparing medicine processing step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 5
The raw material composition of effective ingredient of the present invention and weight are:
The process for preparing medicine processing step of the present embodiment and usage and dosage identical with embodiment 1.
Clinical data:
1, case selection:
As the leukemic medicine for the treatment of, select the routine clinical observation of leukaemic 174 of making a definite diagnosis, patient is divided into treatment group and matched group two groups at random, treatment group 87 example, wherein male 43 example, women 44 example, 21 ~ 62 years old age, 41.5 years old mean age, average course of disease 2.3 years; Matched group 87 example, wherein male 44 example, women 43 example, 20 ~ 61 years old age, 40.5 years old mean age, average course of disease 1.8 years.
The course of disease, the degrees of symptoms for the treatment of group and matched group two groups of cases are basically identical, without significant difference, have comparability.
2, medicament selection:
Treatment group takes medicine of the present invention, oral, every day 2 times, each 1 time sooner or later, each 2 (every sheet 0.5g), warm water delivery service after meal; Within 18 days, be 1 course for the treatment of, 2 ~ 3 courses for the treatment of can fully recover, and the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
Matched group uses Nimustine, common dose: 2 ~ 3mg/kg body weight/time, the used time dissolves (5mg/ml) with water for injection, quiet note; Thereafter according to surrounding hemogram drug withdrawal 4 ~ 6 weeks, or 2mg/kg body weight/time, intravenously administrable, gave once every 1 week again, after 2 ~ 3 weeks, thereafter according to surrounding hemogram drug withdrawal 4-6 week; Should use immediately after this product is mixed with solution.
3, efficacy determination:
(1) cure: symptom all disappears, and physical recovery is normal.
(2) effective: symptom is clearly better, health recovers to some extent.
(3) effective: symptom takes a turn for the better to some extent, and health obviously recovers.
(4) invalid: by treating rear symptom without alleviating or increasing the weight of.
4, result:
Select in the treatment group of medicine of the present invention, cure 41 examples, effective 24 examples, effective 20 examples, invalid 2 examples, cure rate 47.1%, total effective rate 97.7%.
23 examples are cured, effective 18 examples, effective 16 examples, invalid 30 examples, cure rate 26.4%, total effective rate 65.5% in matched group.
Above result display, the cure rate for the treatment of group and total effective rate are apparently higher than matched group.
Model case is illustrated:
1, Yuan, female, 28 years old, Tianjin people from Hebei District.More than 37.5 DEG C of half a year of patient low grade fever, after gradually to hyperpyrexia 40 DEG C, fail to respond to any medical treatment by multiple antibiotics and disease of bringing down a fever through commune hospital, go to hospital of city, be diagnosed as acute myeloblastic leukemia, be in hospital 40 days, symptom is more and more heavier, high heat is persistent, takes Drug therapy of the present invention upon somebody's introduction, after taking 1 course for the treatment of, symptom takes a turn for the better to some extent, after continuing to take 2 courses for the treatment of, transference cure, recovery from illness.
2, Deng, man, 37 years old, Chongqing Jiangbei people from district.Patient occurs dizzy weak without any inducement, be interrupted the symptoms such as gingival hemorrhage, remove hospital admission, be diagnosed as acute leukemia.Take Drug therapy of the present invention, after taking 1 course for the treatment of, symptom takes a turn for the better to some extent, and after continuing to take 1 course for the treatment of, transference cure, recovery from illness, follows up a case by regular visits to after 1 year without recurrence.
3, certain is permitted, female, 40 years old, Anshan, liaoning Province people.Patient suffers from lymphonodi cervicales and swells, myasthenia of limbs, pale complexion, and two without god, every quotidian fever 37.5 DEG C, every day hectic fever more than ten times, heat must be perspired, and cardiopalmus, breathes hard, to sleep then night sweat, suffocating pain over the chest, cough is spat, sputum mixed with blood, remove examination in hospital, be diagnosed as acute leukemia, treat through multiple method, poor effect, take Drug therapy of the present invention, after taking 1 course for the treatment of, symptom takes a turn for the better to some extent, after continuing to take 2 courses for the treatment of, transference cure, recovery from illness, follows up a case by regular visits to so far without recurrence.
4, Fu, man, 45 years old, Shandong Zibo people.Entire patient is weak, abdominal distention, left abdominal part enlargement, be diagnosed as chronic myelocytic leukemia at local hospital, successively toss about in bed many hospital admissions, effect is all undesirable, upon somebody's introduction, to our hospital, give Drug therapy of the present invention, after taking 1 course for the treatment of, symptom takes a turn for the better to some extent, after continuing to take 2 courses for the treatment of, and transference cure, recovery from illness, follows up a case by regular visits to after 2 years without recurrence.
5, Shen, female, 53 years old, Quanzhou, Fujian people.Patient's cases with leukemia 1 year, treated by multiple method, all have no improvement, can only bone marrow transplantation be waited for, but due to the bone marrow of non-distribution type success always, delay to get off always, rear patient recommends to our hospital through doctor, give and take Drug therapy of the present invention, after taking 2 courses for the treatment of, transference cure, recovery from illness is followed up a case by regular visits to and is not recurred.
6, Zeng, man, 59 years old, Mianyang, Sichuan people.Patient occurred that before half a year physical function declines, after in walk time fall in a swoon suddenly, be admitted to hospital, be diagnosed as leukemia, take Drug therapy of the present invention, after taking 1 course for the treatment of, symptom takes a turn for the better to some extent, after continuing to take 2 courses for the treatment of, transference cure, recovery from illness, follows up a case by regular visits to so far without recurrence.

Claims (5)

1. treat a leukemic medicine, it is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:
Folium Musae 18 ~ 42 parts of Semen Platycladi 16 ~ 40 parts of Herba Erysimi Cheiranthoidiss 15 ~ 39 parts of Radix Chimonanthi praecocis 15 ~ 39 parts
Fructus Melodini Suaveolentis 14 ~ 38 parts of Cladonia alpestris (L.) Rabenh.s 13 ~ 37 parts of Herba Swertiae heteranthaes 13 ~ 37 parts of Folium Lantanae Camaraes 12 ~ 36 parts
Semen Aesculi 12 ~ 36 parts of Herba Cymbidii Penduli 10 ~ 34 portions of Herba Artemisiae Scopariaes 9 ~ 33 parts of Stigma Maydis 9 ~ 33 parts
Herba Hyperici Sampsonii 7 ~ 31 parts of Radix Polygalaes 6 ~ 30 parts of Folium Pruni pseudocerasis 6 ~ 30 portions of Fructus seu radix camptothecae acuminatae (Fructus Camptothecae Acuminatae)s 3 ~ 27 parts.
2. one according to claim 1 treats leukemic medicine, it is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:
Folium Musae 22 ~ 38 parts of Semen Platycladi 20 ~ 36 parts of Herba Erysimi Cheiranthoidiss 19 ~ 35 parts of Radix Chimonanthi praecocis 19 ~ 35 parts
Fructus Melodini Suaveolentis 18 ~ 34 parts of Cladonia alpestris (L.) Rabenh.s 17 ~ 33 parts of Herba Swertiae heteranthaes 17 ~ 33 parts of Folium Lantanae Camaraes 16 ~ 32 parts
Semen Aesculi 16 ~ 32 parts of Herba Cymbidii Penduli 14 ~ 30 portions of Herba Artemisiae Scopariaes 13 ~ 29 parts of Stigma Maydis 13 ~ 29 parts
Herba Hyperici Sampsonii 11 ~ 27 parts of Radix Polygalaes 10 ~ 26 parts of Folium Pruni pseudocerasis 10 ~ 26 portions of Fructus seu radix camptothecae acuminatae (Fructus Camptothecae Acuminatae)s 7 ~ 23 parts.
3. one according to claim 1 treats leukemic medicine, it is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:
Folium Musae 26 ~ 34 parts of Semen Platycladi 24 ~ 32 parts of Herba Erysimi Cheiranthoidiss 23 ~ 31 parts of Radix Chimonanthi praecocis 23 ~ 31 parts
Fructus Melodini Suaveolentis 22 ~ 30 parts of Cladonia alpestris (L.) Rabenh.s 21 ~ 29 parts of Herba Swertiae heteranthaes 21 ~ 29 parts of Folium Lantanae Camaraes 20 ~ 28 parts
Semen Aesculi 20 ~ 28 parts of Herba Cymbidii Penduli 18 ~ 26 portions of Herba Artemisiae Scopariaes 17 ~ 25 parts of Stigma Maydis 17 ~ 25 parts
Herba Hyperici Sampsonii 15 ~ 23 parts of Radix Polygalaes 14 ~ 22 parts of Folium Pruni pseudocerasis 14 ~ 22 portions of Fructus seu radix camptothecae acuminatae (Fructus Camptothecae Acuminatae)s 11 ~ 19 parts.
4. one according to claim 1 treats leukemic medicine, it is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:
Folium Musae 30 parts of Semen Platycladi 28 parts of Herba Erysimi Cheiranthoidiss 27 parts of Radix Chimonanthi praecocis 27 parts
Fructus Melodini Suaveolentis 26 parts of Cladonia alpestris (L.) Rabenh.s 25 parts of Herba Swertiae heteranthaes 25 parts of Folium Lantanae Camaraes 24 parts
Semen Aesculi 24 parts of Herba Cymbidii Penduli 22 portions of Herba Artemisiae Scopariaes 21 parts of Stigma Maydis 21 parts
Herba Hyperici Sampsonii 19 parts of Radix Polygalaes 18 parts of Folium Pruni pseudocerasis 18 portions of Fructus seu radix camptothecae acuminatae (Fructus Camptothecae Acuminatae)s 15 parts.
5. as described in any one of Claims 1 to 4, treat a preparation method for leukemic medicine, it is characterized in that: comprise following processing step:
(1) Folium Musae, Herba Erysimi Cheiranthoidis, Folium Lantanae Camarae and Semen Aesculi are put into container, carry out pulverization process, grind into powder, cross 180 order fine powders, for subsequent use;
(2) Semen Platycladi, Radix Chimonanthi praecocis and Folium Pruni pseudocerasi are cleaned, immerse the alcohol solution dipping 1 ~ 2 hour of 80% of 5 times amount, heating extraction 3 hours, reclaim ethanol, filter, obtain filtrate, at simmer down to 65 DEG C, relative density is the thick paste of 1.12 ~ 1.16, for subsequent use;
(3) Fructus Melodini Suaveolentis and Herba Artemisiae Scopariae are cleaned, chopping, puts into container, strand juice, and filter impurity, stays juice for subsequent use;
(4) Cladonia alpestris (L.) Rabenh., Herba Swertiae heteranthae, Herba Cymbidii Penduli, Stigma Maydis, Herba Hyperici Sampsonii, Radix Polygalae and Fructus seu radix camptothecae acuminatae (Fructus Camptothecae Acuminatae) are cleaned, put into container, add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate, being condensed into relative density at 60 DEG C is the thick paste of 1.10 ~ 1.13, for subsequent use;
(5) by thick paste, juice and the fine powder mixing obtained by above-mentioned steps (1) ~ (4), make tablet, obtain the leukemic medicine of described treatment.
CN201410522616.5A 2014-10-04 2014-10-04 Drug for treating leukaemia and preparation method Pending CN104225340A (en)

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