CN104474353A - Medicine for treating myasthenia gravis and preparation method of medicine - Google Patents
Medicine for treating myasthenia gravis and preparation method of medicine Download PDFInfo
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A61K2236/50—Methods involving additional extraction steps
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Abstract
The invention discloses a medicine for treating myasthenia gravis and a preparation method of the medicine and belongs to the field of traditional Chinese medicines. Effective components of the medicine comprise raw materials as follows: white fungus, roots of wingedstem treebine, insects, ardisia maculosa, Chinese starjasmine stems, Chinese yams, silk cotton, tartarian buckwheat root tubers, herbs of hairy fruit violet, hazelnuts, light wheat, honeycombs, chrysanthemum morofolium ramat, whole herbs of stylophorum lasiocarpum, pleurotus ostreatus and antlers. Medicinal materials of the medicine are compatible, the medicine conforms to traditional Chinese medicine and modern medicine theories, has effects of nourishing the liver and the kidney, strengthening the spleen, removing blood stagnation, calming the liver and improving eyesight, has the unique curative effect on the myasthenia gravis and is significant in curative effect, convenient to take, safe and free of toxic and side effects, the pain of myasthenia gravis patients is relieved, the myasthenia gravis does not recur after cured, and both symptoms and root causes can be treated.
Description
Art
The present invention relates to the field of Chinese medicines, particularly relate to a kind of medicine and preparation method for the treatment of myasthenia gravis.
Background technology
Myasthenia gravis is a kind of autoimmune disease caused by neuromuscular junction propagation function obstacle, and clinical main manifestations is part or whole body skeletal muscle weakness and fatiguability, exacerbation of symptoms after movable, and after having a rest, symptom alleviates.Prevalence is 77 ~ 15,0/1,000,000, and annual morbidity is 4 ~ 1,1/1,000,000.Women's prevalence is greater than male, about 3:2, and each age group all has morbidity.The pathogenic factor of myasthenia gravis divides two large classes, and a class is inborn genetic, Ji Shaojian, has nothing to do with autoimmune; Equations of The Second Kind is autoimmune disease, the most common.Pathogenic factor is still not clear, generally believe with infect, medicine, environmental factors be relevant.Simultaneously have 65% ~ 80% to have thymic hyperplasia in Patients With Myasthenia Gravis, 10% ~ 20% occurs together thymoma.Myasthenia gravis initial stage patient often feels eye or the swollen discomfort of limbs acid, or blurred vision is easily tired, tiredly when heat or menstrual onset increases the weight of.Along with PD, the obvious fatigue and weak of skeletal muscle, distinguishing feature is myasthenia in afternoon or tired postemphasis at dusk, and rise morning or alleviate after having a rest, this kind of phenomenon is referred to as " light dusk in morning is heavy ".
Myasthenia Gravis Crisis refers to that the state of an illness that Patients With Myasthenia Gravis occurs suddenly for a certain reason in the course of disease sharply worsens, dyspnea, life-threatening critical phenomenon.According to different reasons, myasthenic crisis is caused by the development due to disease itself mostly.Also can because infecting, overtired, direct stimulation, menstruation, childbirth, operation, wound and bringing out.Clinical manifestation is that the myasthenia symptom of patient increases the weight of suddenly, and occur swallowing with expectoration unable, dyspnea, often accompanies dysphoria, the symptoms such as dripping sweat.
Current myasthenia gravis is a kind of disease of very difficult healing, and some Drug therapy can only be cured the symptoms, not the disease, and conventional has dependency and side effect, and be easy to recurrence after healing, therapeutic effect is not good.Therefore, the medicine of a kind of safe and effective treatment myasthenia gravis of each hospital's research and development is very with practical value.
Summary of the invention
The invention provides a kind of medicine and preparation method for the treatment of myasthenia gravis; Selected by medicine of the present invention, medical material compatibility is suitable, meet Chinese medicine and pharmacy and modern medicine theory, and have that nourishing the liver and kidney, spleen invigorating row are stagnant, effect of suppressing the hyperactive liver improving eyesight, to treatment myasthenia gravis, there is unique curative effect, and evident in efficacy, Patients With Myasthenia Gravis is broken away from misery, taking convenience, non-relapse after healing, safe without toxic side effect, can reach the object for the treatment of both the principal and secondary aspects of a disease.
For achieving the above object, technical scheme of the present invention is implemented as follows:
Treat a medicine for myasthenia gravis, raw material composition and the parts by weight of making described effective ingredient are:
Raw material composition and the parts by weight of making described effective ingredient are:
Raw material composition and the parts by weight of making described effective ingredient are:
Raw material composition and the parts by weight of making described effective ingredient are:
Treat a preparation method for the medicine of myasthenia gravis, comprise following processing step:
(1) by Tremella, Fructus Tritici Levis, Flos Chrysanthemi with pick up the ears to clean, put into container, add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate, being condensed into relative density at 60 DEG C is the thick paste of 1.10 ~ 1.13, for subsequent use;
(2) Radix Cissi hexangularis, Herba Ardisiae Maculosae, Caulis Trachelospermi, Radix Et Rhizoma Fagopyri Tatarici, Herba Violae Collinae and bean leaf seven are cleaned, immerse the alcohol solution dipping 1 ~ 2 hour of 80% of 5 times amount, heating extraction 3 hours, reclaim ethanol, filter, obtain filtrate, for subsequent use;
(3) Martianus dermestoides Chevr., Rhizoma Dioscoreae, silk cotton, Semen coryli heterophyllae, Nidus Vespae and Cornu Cervi are put into container, carry out pulverization process, grind into powder, cross 180 order fine powders, for subsequent use;
(4) by the thick paste obtained by above-mentioned steps (1) ~ (3), filtrate and fine powder mixing, make tablet, obtain the medicine for the treatment of myasthenia gravis of the present invention.
The property of medicine of the present invention's Chinese medicine used is as follows:
Tremella: sweet in the mouth, light, property is put down, nontoxic; Return lung, stomach, kidney channel.Nourishing is promoted the production of body fluid, lung moistening nourishing the stomach.Have strong essence, the kidney invigorating, intestine moistening, stomach reinforcing, QI invigorating and blood, heart tonifying, YIN nourishing, lung moistening, promote the production of body fluid, strong body, supplementing the brain, refresh oneself, improve looks, effect of skin care, life lengthening." pearl sac " carries: " stomach of foot Yang Ming, hands sun bright large intestine, lung meridian." modern medicine study confirmation, Tremella can make the metabolism of people strengthen, and blood circulation is vigorous, and the function of each histoorgan improves, and the elasticity of skin strengthens, and subcutaneous tissue is plentiful, and wrinkle shoals and even disappears, and skin becomes delicate smooth.
Radix Cissi hexangularis: mildly bitter flavor, cool in nature; Return liver, kidney channel.Dispelling, collateral-activating, removing blood stasis and activating blood flow.For rheumatic arthritis, lumbar muscle strain, traumatic injury." Xinhua's book on Chinese herbal medicine outline " carries: " mildly bitter flavor; Cool in nature.There is the function of dispelling, collateral-activating, removing blood stasis and activating blood flow.For rheumatic arthritis, lumbar muscle strain, traumatic injury.”
Martianus dermestoides Chevr.: acrid in the mouth, sweet, warm in nature; Return lung, stomach, large intestine channel.Warming middle-JIAO is regulated the flow of vital energy, promoting blood circulation and stopping pain, expelling wind and removing dampness.Main heart peratodynia, abdominal distention is vomited and diarrhoea, and fall information retrieval damage, hemiplegia, paralysis due to windstroke, limbs flaccidity syndrome and arthralgia syndrome, epersalgia cough, menstruation is lowered, leucorrhea with red and white discharge.
Herba Ardisiae Maculosae: acrid in the mouth, hardship, slightly warm in nature; Return liver, kidney, lung meridian.Promoting blood circulation and stopping pain, clearing throat.Main traumatic injury, fracture, rheumatic arthralgia, diphtheria, laryngopharynx swelling and pain, gastric ulcer.
Caulis Trachelospermi: bitter in the mouth, cold nature; GUIXIN, liver, kidney channel.Dispelling wind and removing obstruction in the collateral, removing heat from blood is subsided a swelling.For beriberoid pyretic arthralgia, the contracture of muscle arteries and veins, soreness of waist and knee joint, sore throat, carbuncle, injury from falling down.Modern medicine study confirms, Caulis Trachelospermi 50% decoct has inhibitory action to staphylococcus aureus, shigella flexneri and Bacillus typhi.
Rhizoma Dioscoreae: sweet in the mouth, property is put down; Return spleen, lung, kidney channel.Spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission.For insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, and deficiency-heat is quenched one's thirst.Rhizoma Dioscoreae (parched with bran) spleen reinforcing stomach invigorating.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, leukorrhagia." detailed outline " carries: " stopping leak dysentery, reduce phlegm saliva, profit fur for kidney tonifying gas, strengthening the spleen and stomach.”
Silk cotton: acrid in the mouth, sweet, property is put down; Enter stomach, large intestine channel.Clearing away heat-damp and promoting diuresis, promoting blood circulation and detumescence.Cure mainly chronic gastritis, gastric ulcer, have loose bowels, dysentery, waist foot is unsuccessful, and lower limb knee joint pain, skin ulcer are swollen, traumatic injury etc.Modern medicine study confirms, silk cotton has clearing away heat and cooling blood, removes stagnant removing food stagnancy, regulates human immunity and anticancer function.
Radix Et Rhizoma Fagopyri Tatarici: sweet in the mouth, property is put down, and mild toxicity, returns spleen, stomach, large intestine channel.Spleen invigorating row is stagnant, regulating QI to relieve pain, removing toxic substances and promoting subsidence of swelling.Cure mainly epigastric distending pain, dyspepsia, dysentery, lumbago and skelalgia, traumatic injury, carbuncle malignant boil, lyssodexis." Inner Mongol Chinese herbal medicine " carries: " removing damp and stopping pain, removing toxic substances and promoting subsidence of swelling, stomach invigorating.Control traumatic injury, lumbago and skelalgia, sore and toxic, dyspepsia.”
Herba Violae Collinae: bitter in the mouth, pungent, cold in nature; Return lung meridian.Heat-clearing and toxic substances removing, detumescence hemostasis.Control skin sore, lung abscess, traumatic injury, knife injury is hemorrhage." Quanzhou book on Chinese herbal medicine " carries: " heat-clearing and toxic substances removing moves back Huang pain relieving.Control swollen ulcer drug, scrofula malignant boil, and various suppurative skin infection.”
Semen coryli heterophyllae: sweet in the mouth, property is put down.Invigorating the spleen and regulating the stomach, nourishing the lung to arrest cough.Main weak after being ill; Diarrhea due to hypofunction of the spleen; Inappetence; Cough." Kaibao Bencao " carries: " main physical strength profiting, wide the intestines and stomach make us not hungry, hike.”
Fructus Tritici Levis: sweet in the mouth, cool in nature; GUIXIN warp.Only sweating due to debility, tranquilizing by nourishing the heart.For the empty hyperhidrosis of body, hysteria." modern Practical Chinese medicinal " carries: " reinforcing the heart, only tired, heat extraction, arresting sweating, diuresis.”
Nidus Vespae: sweet in the mouth, property is put down, and returns stomach warp.Dispel the wind counteracting toxic substances, parasite killing pain relieving, antiallergic." choosing of Simao, Yunnan Chinese herbal medicine " carries: " relaxing muscles and tendons and activating QI and blood in the collateral, method rheumatism, diuresis.Cure mainly rheumatic arthritis, waist knee joint arthralgia chiefly caused by damp pathogen, oedema due to nephritis." modern medicine study confirmation, Nidus Vespae preparation has the effect promoting Immune Function.
Flos Chrysanthemi: acrid in the mouth, sweet, bitter, cold nature; Return lung, Liver Channel.Dispelling wind and heat pathogens, suppressing the hyperactive liver improving eyesight, heat-clearing and toxic substances removing.Have wind and heat dispersing, purging liver-fire receives the merit of nourishing the liver and kidney, tonifying YIN improving eyesight altogether.
Bean leaf seven: bitter in the mouth, cool in nature; Return lung, kidney, Liver Channel.Invigorating the lung and the kidney, clearing and antitussive, dissipating blood stasis stops blooding.Cure mainly cough due to consumptive disease, lumbago due to renal deficiency, have sore throat, treating swelling and pain by traumatic injury, traumatic hemorrhage.
Pick up the ears: acrid in the mouth, sweet, warm in nature; Return liver, kidney channel.Wind-evil dispelling and cold-evil expelling, relaxing muscles and tendons and activating QI and blood in the collateral, kidney invigorating and YANG supporting.Main lumbago and skelalgia, numb hand and foot, grain does not relax, impotence and seminal emission, weakness of the waist and knees." Xinhua's book on Chinese herbal medicine outline " carries: " have the effect such as relaxing muscles and tendons and activating QI and blood in the collateral, wind-evil dispelling and cold-evil expelling, be used for tonic.”
Cornu Cervi: salty in the mouth, warm in nature; Return liver, kidney channel.The kidney warming sun, bone and muscle strengthening, promoting the circulation of blood is subsided a swelling.For impotence and seminal emission, spinal column cold type of pain, carbuncle of yin nature skin infection, acute mastitis is from the beginning of, swelling and pain due to blood stasis." not Lu " carries: " except lower abdomen blood shoot, pain along the spinal column, injured stagnant blood, QI invigorating.”
The present invention compared with prior art, has following beneficial effect:
Selected by medicine of the present invention, medical material compatibility is suitable, meet Chinese medicine and pharmacy and modern medicine theory, and have that nourishing the liver and kidney, spleen invigorating row are stagnant, effect of suppressing the hyperactive liver improving eyesight, to treatment myasthenia gravis, there is unique curative effect, and evident in efficacy, Patients With Myasthenia Gravis is broken away from misery, taking convenience, non-relapse after healing, safe without toxic side effect, can reach the object for the treatment of both the principal and secondary aspects of a disease.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
The raw material composition of effective ingredient of the present invention and weight are:
Treat a preparation method for the medicine of myasthenia gravis, comprise following processing step:
(1) by Tremella, Fructus Tritici Levis, Flos Chrysanthemi with pick up the ears to clean, put into container, add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate, being condensed into relative density at 60 DEG C is the thick paste of 1.10 ~ 1.13, for subsequent use;
(2) Radix Cissi hexangularis, Herba Ardisiae Maculosae, Caulis Trachelospermi, Radix Et Rhizoma Fagopyri Tatarici, Herba Violae Collinae and bean leaf seven are cleaned, immerse the alcohol solution dipping 1 ~ 2 hour of 80% of 5 times amount, heating extraction 3 hours, reclaim ethanol, filter, obtain filtrate, for subsequent use;
(3) Martianus dermestoides Chevr., Rhizoma Dioscoreae, silk cotton, Semen coryli heterophyllae, Nidus Vespae and Cornu Cervi are put into container, carry out pulverization process, grind into powder, cross 180 order fine powders, for subsequent use;
(4) by the thick paste obtained by above-mentioned steps (1) ~ (3), filtrate and fine powder mixing, make tablet, obtain the medicine for the treatment of myasthenia gravis of the present invention.
Usage and dosage: oral, every day 2 times, each 1 time sooner or later, each 2 (every sheet 0.5g), warm water delivery service after meal; Within 5 days, be 1 course for the treatment of, 2 ~ 3 courses for the treatment of can fully recover, and the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
Embodiment 2
The raw material composition of effective ingredient of the present invention and weight are:
The process for preparing medicine processing step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 3
The raw material composition of effective ingredient of the present invention and weight are:
The process for preparing medicine processing step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 4
The raw material composition of effective ingredient of the present invention and weight are:
The process for preparing medicine processing step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 5
The raw material composition of effective ingredient of the present invention and weight are:
The process for preparing medicine processing step of the present embodiment and usage and dosage identical with embodiment 1.
Clinical data:
1, case selection:
As the medicine for the treatment of myasthenia gravis, select the routine clinical observation of Patients With Myasthenia Gravis 164 of making a definite diagnosis, patient is divided into treatment group and matched group two groups at random, treatment group 82 example, wherein male 41 example, women 41 example, 30 ~ 67 years old age, 48.5 years old mean age, average course of disease 12 months; Matched group 82 example, wherein male 41 example, women 41 example, 31 ~ 66 years old age, 48.5 years old mean age, average course of disease 12 months.
The course of disease, the degrees of symptoms for the treatment of group and matched group two groups of cases are basically identical, without significant difference, have comparability.
2, medicament selection:
Treatment group takes medicine of the present invention, oral, every day 2 times, each 1 time sooner or later, each 2 (every sheet 0.5g), warm water delivery service after meal; Within 5 days, be 1 course for the treatment of, 2 ~ 3 courses for the treatment of can fully recover, and the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
Matched group takes pyridostigmine bromide sheet, oral, and general adult is 60 ~ 120mg (1 ~ 2), and every 3 ~ 4 hours once.
3, efficacy determination:
(1) cure: above-mentioned symptom all disappears, and physical recovery is normal.
(2) effective: above-mentioned symptom obviously alleviates, health is clearly better.
(3) effective: above-mentioned symptom alleviates to some extent, and health takes a turn for the better to some extent.
(4) invalid: by treating rear above-mentioned symptom without alleviating or increasing the weight of.
4, result:
Select in the treatment group of medicine of the present invention, cure 43 examples, effective 21 examples, effective 16 examples, invalid 2 examples, cure rate 52.4%, total effective rate 97.6%.
30 examples are cured, effective 20 examples, effective 13 examples, invalid 19 examples, cure rate 36.6%, total effective rate 76.8% in matched group.
Above result display, the cure rate for the treatment of group and total effective rate are apparently higher than matched group.
Model case is illustrated:
1, Huang, man, 32 years old, people from Putuo District Shanghai.Patient suffers from myasthenia gravis, use western medical treatment, treatment a period of time after effect have no improvement, after take Drug therapy of the present invention, after taking 1 course for the treatment of, symptom is obviously alleviated, after continuing to take 2 courses for the treatment of, symptom all disappears, and recovery from illness, follows up a case by regular visits to after half a year and have no recurrence.
2, Wu, female, 41 years old, Heilungkiang Suihua people.Patient is bad because sleeping, there is tired and mild cold symptoms, remove examination in hospital, two lower limb weakness, be diagnosed as myasthenia gravis, through taking Drug therapy of the present invention, after taking 1 course for the treatment of, symptom is clearly better, after continuing to take 1 course for the treatment of, symptom disappears completely, recovery from illness, follows up a case by regular visits to so far without recurrence.
3, grandson, man, 53 years old, people from Fuling Chongqing.Patient main suit suffered from myasthenia gravis more than 1 year, through regular incidence, used multiple Drug therapy, poor effect, and through taking Drug therapy of the present invention, after taking 1 course for the treatment of, symptom is alleviated to some extent, and after taking 2 courses for the treatment of, symptom all disappears, and followed up a case by regular visits to without recurrence after half a year.
4, Zhu, female, 37 years old, Distributions in Liaocheng of Shandong Province people.Patient has expectorant, hoarseness, ambiguous, removes hospital admission, be diagnosed as left eye blepharoptosis myasthenia gravis, take Drug therapy of the present invention, after taking 1 course for the treatment of, symptom is clearly better, after taking 3 courses for the treatment of, symptom all disappears, recovery from illness, follows up a case by regular visits to without recurrence after 1 year.
5, high certain, man, 46 years old, people from Shijiazhuang, Hebei.Patient is because of long-distance running, and occur tired and mild cold symptoms, on inspection two weakness of the lower extremities, through taking Drug therapy of the present invention, after taking 1 course for the treatment of, symptom is alleviated to some extent, and after continuing to take 2 courses for the treatment of, symptom all disappears, and follows up a case by regular visits to and do not recur after 1 year.
6, what certain, female, 60 years old, people from Nanjing.Patient body discomfort removes examination in hospital, checks as blepharoptosis Patients With Myasthenia Gravis, and through taking Chinese medicine preparation of the present invention treatment, after taking 1 course for the treatment of, symptom takes a turn for the better to some extent, and after continuing to take 2 courses for the treatment of, symptom all disappears, recovery from illness, follows up a case by regular visits to so far without recurrence.
Claims (5)
1. treat a medicine for myasthenia gravis, it is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:
Tremella 38 ~ 61 parts of Radix Cissi hexangulariss 35 ~ 59 parts of Martianus dermestoides Chevr. 34 ~ 58 parts of Herba Ardisiae Maculosaes 32 ~ 56 parts
Caulis Trachelospermi 30 ~ 54 portions of Rhizoma Dioscoreaes 28 ~ 52 parts of silk cotton 27 ~ 51 parts of Radix Et Rhizoma Fagopyri Tatarici 26 ~ 50 parts
17 ~ 41 parts, Herba Violae Collinae 23 ~ 47 portions of Semen coryli heterophyllaes 22 ~ 46 portions of Fructus Tritici Levis 19 ~ 43 parts of Nidus Vespae
7 13 ~ 36 parts, Flos Chrysanthemi 15 ~ 39 parts of bean leaves are picked up the ears 10 ~ 28 parts, 13 ~ 32 parts of Cornu Cervis.
2. a kind of medicine for the treatment of myasthenia gravis according to claim 1, is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:
Tremella 41 ~ 57 parts of Radix Cissi hexangulariss 39 ~ 55 parts of Martianus dermestoides Chevr. 38 ~ 54 parts of Herba Ardisiae Maculosaes 36 ~ 52 parts
Caulis Trachelospermi 34 ~ 50 portions of Rhizoma Dioscoreaes 32 ~ 48 parts of silk cotton 31 ~ 47 parts of Radix Et Rhizoma Fagopyri Tatarici 30 ~ 46 parts
21 ~ 37 parts, Herba Violae Collinae 27 ~ 43 portions of Semen coryli heterophyllaes 26 ~ 42 portions of Fructus Tritici Levis 23 ~ 39 parts of Nidus Vespae
7 17 ~ 32 parts, Flos Chrysanthemi 19 ~ 35 parts of bean leaves are picked up the ears 13 ~ 25 parts, 16 ~ 28 parts of Cornu Cervis.
3. a kind of medicine for the treatment of myasthenia gravis according to claim 1, is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:
Tremella 45 ~ 53 parts of Radix Cissi hexangulariss 43 ~ 51 parts of Martianus dermestoides Chevr. 42 ~ 50 parts of Herba Ardisiae Maculosaes 40 ~ 48 parts
Caulis Trachelospermi 38 ~ 46 portions of Rhizoma Dioscoreaes 36 ~ 44 parts of silk cotton 35 ~ 43 parts of Radix Et Rhizoma Fagopyri Tatarici 34 ~ 42 parts
25 ~ 33 parts, Herba Violae Collinae 31 ~ 39 portions of Semen coryli heterophyllaes 30 ~ 38 portions of Fructus Tritici Levis 27 ~ 35 parts of Nidus Vespae
7 20 ~ 28 parts, Flos Chrysanthemi 23 ~ 31 parts of bean leaves are picked up the ears 16 ~ 22 parts, 19 ~ 25 parts of Cornu Cervis.
4. a kind of medicine for the treatment of myasthenia gravis according to claim 1, is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:
Tremella 49 parts of Radix Cissi hexangulariss 47 parts of Martianus dermestoides Chevr. 46 parts of Herba Ardisiae Maculosaes 44 parts
Caulis Trachelospermi 42 portions of Rhizoma Dioscoreaes 40 parts of silk cotton 39 parts of Radix Et Rhizoma Fagopyri Tatarici 38 parts
29 parts, Herba Violae Collinae 35 portions of Semen coryli heterophyllaes 34 portions of Fructus Tritici Levis 31 parts of Nidus Vespae
7 24 parts, Flos Chrysanthemi 27 parts of bean leaves are picked up the ears 19 parts, 22 parts of Cornu Cervis.
5. as described in any one of Claims 1 to 4, treat a preparation method for the medicine of myasthenia gravis, it is characterized in that: comprise following processing step:
(1) by Tremella, Fructus Tritici Levis, Flos Chrysanthemi with pick up the ears to clean, put into container, add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate, being condensed into relative density at 60 DEG C is the thick paste of 1.10 ~ 1.13, for subsequent use;
(2) Radix Cissi hexangularis, Herba Ardisiae Maculosae, Caulis Trachelospermi, Radix Et Rhizoma Fagopyri Tatarici, Herba Violae Collinae and bean leaf seven are cleaned, immerse the alcohol solution dipping 1 ~ 2 hour of 80% of 5 times amount, heating extraction 3 hours, reclaim ethanol, filter, obtain filtrate, for subsequent use;
(3) Martianus dermestoides Chevr., Rhizoma Dioscoreae, silk cotton, Semen coryli heterophyllae, Nidus Vespae and Cornu Cervi are put into container, carry out pulverization process, grind into powder, cross 180 order fine powders, for subsequent use;
(4) by the thick paste obtained by above-mentioned steps (1) ~ (3), filtrate and fine powder mixing, make tablet, obtain the medicine of described treatment myasthenia gravis.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102406798A (en) * | 2011-11-27 | 2012-04-11 | 鲍颖 | Chinese medicinal composition for treating myasthenia gravis |
| CN103041228A (en) * | 2013-01-10 | 2013-04-17 | 尹爱良 | Traditional Chinese medicine composite for treating myasthenia gravis |
| CN104147277A (en) * | 2014-08-29 | 2014-11-19 | 郑树旺 | Traditional Chinese medicinal preparation for treating myasthenia gravis and preparation method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102406798A (en) * | 2011-11-27 | 2012-04-11 | 鲍颖 | Chinese medicinal composition for treating myasthenia gravis |
| CN103041228A (en) * | 2013-01-10 | 2013-04-17 | 尹爱良 | Traditional Chinese medicine composite for treating myasthenia gravis |
| CN104147277A (en) * | 2014-08-29 | 2014-11-19 | 郑树旺 | Traditional Chinese medicinal preparation for treating myasthenia gravis and preparation method |
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| CN105125653A (en) * | 2015-10-20 | 2015-12-09 | 成功 | Drug for treating myasthenia gravis and preparation method thereof |
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