CN108310218A - A kind of Chinese medicine composition for treating ulcerative colitis and preparation method thereof and purposes - Google Patents
A kind of Chinese medicine composition for treating ulcerative colitis and preparation method thereof and purposes Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine composition for treating ulcerative colitis and preparation method thereof and purposes, it is made of the bulk pharmaceutical chemicals of following weight proportion：10~28 parts of the coptis, 12~30 parts of indigo naturalis, 5~14 parts of nutmeg, 5~15 parts of psoralea corylifolia, 7~15 parts of myrobalan, 15~30 parts of the Chinese bulbul, 10~30 parts of the bletilla striata, 10~28 parts of red halloysite, 10~30 parts of charred POLLEN TYPHAE, 10~30 parts of Chinese gall, 5~13 parts of root of Aucklandia lappa Decne, 10~30 parts of dragon's blood.Chinese medicine composition of the present invention is significant in efficacy to patients of ulcerative colitis, and preparation process is simple, easy to use, has no toxic side effect, and has preferable potential applicability in clinical practice.
Description
Technical field
The invention belongs to tcm fields, and in particular to a kind of Chinese medicine composition that treating ulcerative colitis and its preparation
Method and purposes.
Background technology
Ulcerative colitis (ulcerative colitis, UC), is a kind of chronic colitis, mainly invades and colon is glutinous
The chronic nonspecific inflammatory disease of film, shows as inflammation or ulcer, involves rectum and lower distal colon, but can proximally expand more
Exhibition, so that spread entire colon.Clinical features differ, and can have alleviation to alternate with breaking-out, and patient can only have colon symptom,
Also can occur together constitutional symptom.For 5%~10% routed knot patient with inflammatory arthritis, this arthritis is known as colonic joint
It is scorching.Routed colonic arthritis when making of binding up one's hair can also deteriorate therewith.So such arthritic premise for the treatment of, is first to improve routed knot
This underlying diseases.
Although knot, the rectum of the whole lesions of excision can cure this disease completely in terms for the treatment of；But the cost paid will be that have can
It can be from this lifelong abdomen ileal stoma.The course of disease of the disease is very long, normal recurrent exerbation, sees any age, but 20~30 years old most
See.
This disease belongs to the scopes such as Chinese medicine " dysentery ".Chinese medicine is with a long history, and patient acceptability is good, but clinical efficacy is still not
People's will to the greatest extent, there is an urgent need for a kind of prescriptions effectively treated to treat ulcerative colitis, improve patients ' life quality.
Invention content
To solve the above-mentioned problems, the present invention provides a kind of Chinese medicine composition for treating ulcerative colitis and its preparations
Method and purposes.
The present invention provides a kind of Chinese medicine compositions, it is prepared by the bulk pharmaceutical chemicals of following weight proportion：
10~28 parts of the coptis, 12~30 parts of indigo naturalis, 5~14 parts of nutmeg, 5~15 parts of psoralea corylifolia, 7~15 parts of myrobalan, in vain
15~30 parts of father-in-law of head, 10~30 parts of the bletilla striata, 10~28 parts of red halloysite, 10~30 parts of charred POLLEN TYPHAE, 10~30 parts of Chinese gall, root of Aucklandia lappa Decne 5
~13 parts, 10~30 parts of dragon's blood.
Preferably, it is prepared by the bulk pharmaceutical chemicals of following weight proportion：
15~23 parts of the coptis, 15~25 parts of indigo naturalis, 8~13 parts of nutmeg, 8~12 parts of psoralea corylifolia, 8~12 parts of myrobalan, in vain
17~25 parts of father-in-law of head, 15~25 parts of the bletilla striata, 15~25 parts of red halloysite, 15~25 parts of charred POLLEN TYPHAE, 15~24 parts of Chinese gall, root of Aucklandia lappa Decne 8
~12 parts, 15~25 parts of dragon's blood.
It is further preferred that it is prepared by the bulk pharmaceutical chemicals of following weight proportion：
20 parts of the coptis, 20 parts of indigo naturalis, 10 parts of nutmeg, 10 parts of psoralea corylifolia, 10 parts of myrobalan, 20 parts of the Chinese bulbul, 20 parts of the bletilla striata,
20 parts of red halloysite, 20 parts of charred POLLEN TYPHAE, 20 parts of Chinese gall, 10 parts of root of Aucklandia lappa Decne, 20 parts of dragon's blood.
The Chinese medicine composition be with the coptis, indigo naturalis, nutmeg, psoralea corylifolia, myrobalan, the Chinese bulbul, the bletilla striata, red halloysite,
Charred POLLEN TYPHAE, Chinese gall, root of Aucklandia lappa Decne, the crude drug of dragon's blood, water extract or extractive with organic solvent are active constituent, in addition pharmaceutically
Preparation is prepared in acceptable auxiliary material.
Further, the preparation is solution, liniment, ointment, gelling agent, suppository.
Preferably, the preparation is solution.
The present invention provides a kind of methods preparing the Chinese medicine composition, it includes the following steps：
(1) bulk pharmaceutical chemicals of each weight proportion are weighed；
(2) dry, pulverize, sieving to get.
Wherein, in step (2), the sieving was 120 mesh sieve.
Purposes of the Chinese medicine composition in the drug for preparing treatment ulcerative colitis.
The administering mode of preparation of the present invention is rectally；Specially Rectolysis, enema or suppository are filled in
Method；Preferably Rectolysis.
Chinese medicine composition of the present invention be by the coptis, indigo naturalis, nutmeg, psoralea corylifolia, myrobalan, the Chinese bulbul, the bletilla striata, red halloysite,
Charred POLLEN TYPHAE, Chinese gall, root of Aucklandia lappa Decne, 12 herbal medicine of dragon's blood composition.
Chinese medicine thinks that the dysentery interpretation of the cause, onset and process of an illness is damp and hot, epidemic disease is malicious, cold-dampness knot is in internal organs, makes stagnation of QI-blood, adipose membrane blood network is impaired, changes
For purulence blood, large intestine conducts mistake department, sends out as dysentery.This prescription coptis, the Chinese bulbul, indigo naturalis be clearing heat and detoxicating, dampness-eliminating and dysentery-stopping；Myrobalan, meat
Intestines are consolidated in astringe the lung warm spleen warm kidney, the reinforcing of cardamom, psoralea corylifolia；Charred POLLEN TYPHAE, dragon's blood removing blood stasis and hemostasis；The puckery intestines of the bletilla striata, red halloysite, Chinese gall stop
Blood, myogenic sore；Root of Aucklandia lappa Decne harmonizing the functional activities of vital QI.All medicine resultant forces are played clearing heat and detoxicating, cool blood to disappear carbuncle, removing blood stasis and hemostasis, torr sore myogenic, are consolidated altogether
The work(of intestines stopping leak, full side's simultaneously using both cold and hot drugs, the qi and blood people having the same aspiration and interest, treating both manifestation and root cause of disease.
Chinese medicine composition of the present invention is significant in efficacy to patients of ulcerative colitis, and preparation process is simple, easy to use, nontoxic
Side effect has preferable potential applicability in clinical practice.
The above according to the present invention, according to the ordinary technical knowledge and customary means of relevant art, not
It is detached under the premise of the above-mentioned basic fundamental thought of the present invention, the modification, replacement or change of other diversified forms can also be made.
The specific implementation mode of form by the following examples remakes further specifically the above of the present invention
It is bright.But the range that this should not be interpreted as to the above-mentioned theme of the present invention is only limitted to example below.It is all to be based on the above of the present invention
The technology realized all belongs to the scope of the present invention.
Specific implementation mode
The preparation of 1 Chinese medicine composition of the present invention of embodiment
1. raw material：Coptis 20g, indigo naturalis 20g, nutmeg 10g, psoralea corylifolia 10g, myrobalan 10g, Chinese bulbul 20g, bletilla striata 20g,
Red halloysite 20g, charred POLLEN TYPHAE 20g, Chinese gall 20g, root of Aucklandia lappa Decne 10g, dragon's blood 20g.
2. preparation method：Bulk pharmaceutical chemicals are weighed by above-mentioned weight proportion；Crush be smalls, cross 120 mesh sieve to get.
The preparation of 2 Chinese medicine composition of the present invention of embodiment
1. raw material：Coptis 23g, indigo naturalis 30g, nutmeg 13g, psoralea corylifolia 12g, myrobalan 15g, Chinese bulbul 30g, bletilla striata 30g,
Red halloysite 25g, charred POLLEN TYPHAE 25g, Chinese gall 30g, root of Aucklandia lappa Decne 13g, dragon's blood 30g.
2. preparation method：Bulk pharmaceutical chemicals are weighed by above-mentioned weight proportion；With embodiment 1.
The preparation of 3 Chinese medicine composition of the present invention of embodiment
1. raw material：Coptis 15g, indigo naturalis 12g, nutmeg 8g, psoralea corylifolia 8g, myrobalan 7g, Chinese bulbul 15g, bletilla striata 25g are red
Mountain tallow 28g, charred POLLEN TYPHAE 15g, Chinese gall 10g, root of Aucklandia lappa Decne 5g, dragon's blood 15g.
2. preparation method：Bulk pharmaceutical chemicals are weighed by above-mentioned weight proportion；With embodiment 1.
The preparation of 4 Chinese medicine composition of the present invention of embodiment
1. raw material：Coptis 28g, indigo naturalis 25g, nutmeg 14g, psoralea corylifolia 15g, myrobalan 12g, Chinese bulbul 25g, bletilla striata 10g,
Red halloysite 15g, charred POLLEN TYPHAE 30g, Chinese gall 24g, root of Aucklandia lappa Decne 8g, dragon's blood 25g.
2. preparation method：Bulk pharmaceutical chemicals are weighed by above-mentioned weight proportion；With embodiment 1.
The preparation of 5 Chinese medicine composition of the present invention of embodiment
1. raw material：Coptis 10g, indigo naturalis 15g, nutmeg 5g, psoralea corylifolia 5g, myrobalan 8g, Chinese bulbul 17g, bletilla striata 15g are red
Mountain tallow 10g, charred POLLEN TYPHAE 10g, Chinese gall 15g, root of Aucklandia lappa Decne 12g, dragon's blood 10g.
2. preparation method：Bulk pharmaceutical chemicals are weighed by above-mentioned weight proportion；With embodiment 1.
Beneficial effects of the present invention are proved below by way of specific clinical test.
The clinical efficacy of 1 present composition of test example
1, clinical data
Test group selection light, moderately active phase patients of ulcerative colitis 60 that 1~December in 2017, this Out-patient Department was accepted for medical treatment
Example, all patients are diagnosed as ulcerative colitis by inspection.Man 32, female 28；26~60 years old age, average age
(40.5 ± 4.1) year.
1.1 diagnostic criteria：
Doctor trained in Western medicine diagnoses：Comprehensive analysis is carried out in conjunction with clinical, scope and Histopathologic appearance, infectivity is excluded and other is non-
Infectious colitis and make diagnosis.Clinical manifestation mainly has purulence blood abdominal distension, diarrhea, abdominal pain, tenesmus etc..Endoscopy
Lesions visible, in continuous, diffusivity distribution, can behave as mostly since straight damage：Mucous membrane hyperemia, oedema, matter is crisp, bleeding or has
Purulence blood sexual secretion, vascular lake is disorderly, fuzzy or disappear；Lesion obviously locates that visible multiple, diffusivity is rotten to the corn or ulcer；It can
See that haustrum shoals or disappears and mucosal bridge, pseudopolyp etc..It is diffusivity in the visible tunica propria of histological examination, acute, chronic
Inflammatory cell infiltration；Crypts structure changes；It can be seen that mucous membrane surface is rotten to the corn, fester is formed and granulation tissue hyperplasia.
It is divided into three degree by severity extent：
1. slight：Diarrhea is less than 4 times daily, and visually the amount of having blood in stool is few or nothing.Slight abdominal pain, extent of disease be confined to rectum,
Sigmoid colon, body temperature is normal, and pulse frequency is normal, and hemoglobin is more than 120g/L, and weight loss is less than 3.5kg, and erythrocyte sedimentation rate is less than 30mm/
h。
2. severe：Diarrhea 6 times a day more than, abdominal pain is heavier, and extent of disease involves total colectomy, and body temperature is higher than 38 DEG C, pulse frequency
More than 90 beats/min, hemoglobin is less than 105g/L, and erythrocyte sedimentation rate is less than 30mm/h, and weight loss is more than 7kg.
3. moderate：Between slightly between severe.
1.2 inclusion criteria
The case for meeting 1.1 section diagnostic criteria is included in.
2, therapy
Experimental group：Give the drug of the embodiment of the present invention 1.
Specifically medication is：Warm water is added when use, wherein warm water and the volume mass ratio of raw material medicinal powder are
100：20mL/g, row Enem-d after mixing, retains, the weight of the drug instilled every time is equivalent to 20 grams of crude drugs, daily as possible
Once in the morning and once at night, it after continuously treating 2 weeks, is changed to once a night, then curative effect is counted after continuous 2 weeks.
3, observation of curative effect
3.1 criterion of therapeutical effect：
It is formulated within 2012 according to Chinese Medical Association's disease for digest credit meeting inflammatory bowel disease group《Diagnosis status of inflammatory bowel disease
With the National Consensus (2012, Guangzhou) for the treatment of》Clinical efficacy standard can be divided into following 3 class：
1. curing：Clinical symptoms disappear, and per rectum spectroscopy finds that mucous membrane is normal or no active inflammation；
2. improving：Clinical symptoms are substantially reduced, and colonoscopy can find mucous membrane mild inflammation；
3. invalid：Clinical symptoms are without improvement, colonoscopy without improvement sign.
Total effective rate=cure rate+improvement rate.
3.2 treatment results
As shown in table 1：
| Group | It cures | It improves | In vain | Cure rate | Total effective rate |
| Experimental group (60 people) | 35 | 25 | 0 | 58.3% | 100% |
Experiment conclusion：60 patients that the present invention is treated cure 35, improve 25, and cure rate reaches 58% or more,
Effective percentage reaches 100%, the results showed that, Chinese medicine preparation reasonable recipe of the present invention is notable to ulcerative colitis curative effect of disease, value
Obtain clinical application.
4, model case
4.1 classical cases 1
Mr. Li, male, 45 years old, mucus bloody stool 5+, aggravated to seek medical advice with 1 Zhou Lai our hospital of weight outpatient service after abdominal pain, dysentery repeatedly.
Electronics colonoscopy and disease inspection prompt ulcerative colitis, extent of disease are related to rectum and sigmoid colon, daily diarrhea 4-5 times, no hair
Heat, 85 beats/min, hemoglobin 110g/L of heart rate, weight mitigates 5kg, erythrocyte sedimentation rate 28mm/h more in the year before last.Hepatic and renal function, blood glucose and electricity
Solution matter is shown no obvious abnormalities.Doctor trained in Western medicine is diagnosed as ulcerative colitis (chronic relapsing；Moderate；Rectum, sigmoid colon involvement；It is living
The dynamic phase), tcm diagnosis is dysentery (syndrome of stagnant and jamming dampness-heat).
Therapy：The drug and preparation method for giving the embodiment of the present invention 1, take 20g fine powders, and 100ml is added in when use
Warm water, row Enem-d after mixing, retains, waits for its natural excrement as possible.Once in the morning and once at night, after continuously treating 2 weeks, change
For once a night, then continuous 2 weeks.
Curative effect：Mucus bloody stool disappears after patient treats 2 weeks, and abdominal pain disappears, tenesmus substantially reduced, is changed to every night one
It is secondary, then continuously treatment checks electronics sigmoidoscope after 2 weeks, finding intestinal segment is shown no obvious abnormalities.
In conclusion Chinese medicine composition of the present invention is significant in efficacy to patients of ulcerative colitis, preparation process is simple, uses
It is convenient, it has no toxic side effect, the unique advantage with external application quick acting and preferable potential applicability in clinical practice.
Claims (9)
1. a kind of Chinese medicine composition, it is characterised in that：It is prepared by the bulk pharmaceutical chemicals of following weight proportion：
10~28 parts of the coptis, 12~30 parts of indigo naturalis, 5~14 parts of nutmeg, 5~15 parts of psoralea corylifolia, 7~15 parts of myrobalan, the Chinese bulbul
15~30 parts, 10~30 parts of the bletilla striata, 10~28 parts of red halloysite, 10~30 parts of charred POLLEN TYPHAE, 10~30 parts of Chinese gall, root of Aucklandia lappa Decne 5~13
Part, 10~30 parts of dragon's blood.
2. Chinese medicine composition according to claim 1, it is characterised in that：It is prepared by the bulk pharmaceutical chemicals of following weight proportion
It forms：
15~23 parts of the coptis, 15~25 parts of indigo naturalis, 8~13 parts of nutmeg, 8~12 parts of psoralea corylifolia, 8~12 parts of myrobalan, the Chinese bulbul
17~25 parts, 15~25 parts of the bletilla striata, 15~25 parts of red halloysite, 15~25 parts of charred POLLEN TYPHAE, 15~24 parts of Chinese gall, root of Aucklandia lappa Decne 8~12
Part, 15~25 parts of dragon's blood.
3. according to Chinese medicine composition described in claim 1, it is characterised in that：It is by following weight proportion bulk pharmaceutical chemicals prepare and
At：
20 parts of the coptis, 20 parts of indigo naturalis, 10 parts of nutmeg, 10 parts of psoralea corylifolia, 10 parts of myrobalan, 20 parts of the Chinese bulbul, 20 parts of the bletilla striata, red stone
20 parts of fat, 20 parts of charred POLLEN TYPHAE, 20 parts of Chinese gall, 10 parts of root of Aucklandia lappa Decne, 20 parts of dragon's blood.
4. according to the Chinese medicine composition described in claims 1 to 3 any one, it is characterised in that：It is with the coptis, indigo naturalis, meat
Cardamom, psoralea corylifolia, myrobalan, the Chinese bulbul, the bletilla striata, red halloysite, charred POLLEN TYPHAE, Chinese gall, root of Aucklandia lappa Decne, the crude drug of dragon's blood, water extract or
Person's extractive with organic solvent is active constituent, in addition preparation is prepared in pharmaceutically acceptable auxiliary material.
5. Chinese medicine composition according to claim 4, it is characterised in that：The preparation be solution, liniment, ointment,
Gelling agent, suppository.
6. Chinese medicine composition according to claim 5, it is characterised in that：The preparation is solution.
7. a kind of method preparing the Chinese medicine composition described in claim 1~6 any one, it is characterised in that：It includes such as
Lower step：
(1) bulk pharmaceutical chemicals of each weight proportion are weighed；
(2) dry, pulverize, sieving to get.
8. preparation method according to claim 7, it is characterised in that：In step (2), the sieving was 120 mesh sieve.
9. use of the Chinese medicine composition in the drug for preparing treatment ulcerative colitis described in claim 1~6 any one
On the way.
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| CN111991387A (en) * | 2020-10-10 | 2020-11-27 | 上海中医药大学 | Application of dehydrodiisobutyrol in preparing medicine for preventing and treating ulcerative colitis |
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| US4150123A (en) * | 1977-11-21 | 1979-04-17 | Wladyslaw Szturma | Method for treating gastro intestinal ulcers with extract of herb cetraria |
| CN101002927A (en) * | 2007-01-25 | 2007-07-25 | 潘金火 | Traditional Chinese medicine capsule for treating chronic ulcerosa colitis, its component and preparing method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111991387A (en) * | 2020-10-10 | 2020-11-27 | 上海中医药大学 | Application of dehydrodiisobutyrol in preparing medicine for preventing and treating ulcerative colitis |
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| CN108310218B (en) | 2020-12-11 |
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