CN104721774A - Traditional Chinese medicine for treating chronic colitis - Google Patents

Abstract

The invention discloses a traditional Chinese medicine for treating chronic colitis, which comprises the following bulk drugs according to weight ratio: 5 parts of costus root, 5 parts of rhizoma coptidis, 10 parts of rhizoma corydalis, 15 parts of raw white peony root, 6 parts of Villous Amomum Fruit, 5 parts of licorice, 30 parts of pseudostellaria root, 15 parts of chicken's gizzard membrane, 15 parts of Psoralea corylifolia, 6 parts of root of kudzu vine, 9 parts of fried honeysuckle flower, 9 parts of poria cocos, 3 parts of dried orange peel, 3 parts of phellodendron, 2.4 parts of ginger processing with supplementary materials, and 2 parts of red halloysite, 1 part of dried ginger, and 3 parts of polished rice. The traditional Chinese medicine has the efficacy for invigorating spleen and smoothing liver, and moving qi and relieving pain, and is mainly used for treating chronic colitis. Compared with pills and capsules having relative treatment efficacy, the traditional Chinese medicine has the advantages of little administration dosage, good mouthfeel, convenient administration, fast absorption, high biology availability, stable quality and simple production process.

Description

A kind of Chinese medicine for the treatment of chronic colitis

Technical field

The invention belongs to technical field of Chinese medicines, particularly a kind of Chinese medicine for the treatment of chronic colitis.

Background technology

Chronic colitis be a kind of chronic, repeatability, multiple with colon, sigmoid colon and rectum for site of pathological change.Refer to that rectum colon causes the inflammatory edema of intestinal, ulcer, hemorrhage pathological changes because of various pathogenesis.Symptom is left lower quadrant pain, diarrhoea, tenesmus, time be just stained with down liquid, constipation or have loose bowels alternately occur, fashion time bad, touching lower disconnected, recurrent exerbation.Chronic colitis is that chronic colon is divided into specificity according to pathogenesis usually, namely has the colitis of obvious cause, and the non-specific colitis that namely pathogenesis is not clear.

Chronic colitis onset is slow, sustainable do not alleviate or movable and static be alternately chronic reaction.Can be there is constipation or symptom of having loose bowels in patient, have defecation frequency to increase, difficult defecation, just lower a large amount of mucus or band blood, time have tenesmus phenomenon, with left lower abdominal pain, in having a dull ache, weight loss, becomes thin, lassitude.After conventional therapy medication, symptom can be eased, and symptom alleviates, and easily recurs after drug withdrawal.Although achieved some experiences by Chinese medicine treatment chronic colitis, also there is the problem that cure rate is low and the course for the treatment of is long at present.Study mechanism is carried out not yet well, and pharmacological research is heavy single medicinal material mainly, then less to the research of compound recipe.The present invention carries out comprehensively deep research from these several respects, improves cure rate further, Shorten the Treatment Process.

Summary of the invention

Object of the present invention aims to provide a kind of Chinese medicine for the treatment of chronic colitis, and it has spleen invigorating soothing liver-QI, and effect of promoting the circulation of QI to relieve pain, cures mainly the diseases such as chronic colitis.Its taking dose is little, mouthfeel good, taking convenience, absorption is very fast, bioavailability is high, steady quality, production technology are simple.

Technical scheme of the present invention is: a kind of Chinese medicine for the treatment of chronic colitis, it is characterized in that the crude drug composition that it contains and weight proportion thereof are: Radix Aucklandiae (Radix Vladimiriae) 5 parts, Rhizoma Coptidis 5 parts, rhizoma corydalis 10 parts, Radix Paeoniae Alba 15 parts, Fructus Amomi 6 parts, 5 parts, Radix Glycyrrhizae, Radix Pseudostellariae 30 parts, Endothelium Corneum Gigeriae Galli 15 parts, Fructus Psoraleae 15 parts, RADIX PUERARIAE 6 parts, Flos Lonicerae 9 parts of speculating in golds, Poria 9 parts, Pericarpium Citri Reticulatae 3 parts, Cortex Phellodendri 3 parts, 2.4 parts, Rhizoma Zingiberis Preparatum carbon, Halloysitum Rubrum 2 parts, Rhizoma Zingiberis 1 part, Semen oryzae sativae 3 parts.

Described a kind of preparation method for the treatment of the Chinese medicine of chronic colitis it comprise the following steps:

1) by following weight ratio weighting raw materials: Radix Aucklandiae (Radix Vladimiriae) 5 parts, Rhizoma Coptidis 5 parts, rhizoma corydalis 10 parts, Radix Paeoniae Alba 15 parts, Fructus Amomi 6 parts, 5 parts, Radix Glycyrrhizae, Radix Pseudostellariae 30 parts, Endothelium Corneum Gigeriae Galli 15 parts, Fructus Psoraleae 15 parts, RADIX PUERARIAE 6 parts, Flos Lonicerae 9 parts of speculating in golds, Poria 9 parts, Pericarpium Citri Reticulatae 3 parts, Cortex Phellodendri 3 parts, 2.4 parts, Rhizoma Zingiberis Preparatum carbon, Halloysitum Rubrum 2 parts, Rhizoma Zingiberis 1 part, Semen oryzae sativae 3 parts;

2) prepare the soak by water secondary that each component mixing of Chinese medicine adds 8 times amount more than in proportion, 2 hours first times, second time 1.5 hours, gradation filters, and merging filtrate, dusts with spray dryer, for subsequent use;

3) dry powder described in step 2 is added starch, anhydrous glucose, stevioside, mix homogeneously;

4) said mixture is added 80% ethanol soft material;

5) granulate with soft material 14 mesh sieve, arrange.

6) subpackage, put in storage.

Advantage of the present invention is: according to the theoretical prescription of traditional Chinese medical science tradition prescription methods combining modern Chinese medicine, have spleen invigorating soothing liver-QI, effect of promoting the circulation of QI to relieve pain, cures mainly the diseases such as chronic colitis.The wherein effect of monarch drug Radix Aucklandiae (Radix Vladimiriae) in prescription, warming middle-JIAO to promote flow of QI pain relieving, strengthening the spleen to promote digestion intestinal stasis relieving.Cure mainly feeling of stuffiness in chest hypochondriac pain, abdominal distention, heavy after dysentery, accumulation of food in the stomach and intes tine due to indigestion, vomiting is had loose bowels, and colic of cold type is suffered from abdominal pain.Rhizoma Coptidis heat clearing and damp drying, eliminating fire and detoxication, for damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tells nosebleed, conjunctival congestion, and toothache, quenches one's thirst, carbuncle furuncle.Other has promoting blood circulation to remove blood stasis, the function of promoting the circulation of QI pain relieving.Also has promoting digestion and invigorating the stomach, arresting seminal emission.Fructus Psoraleae reinforcing the kidney and supporting YANG; Helping inspiration to relieve asthma; Warming spleen and stopping diarrha.Main insufficiency of kidney-YANG; Below element deficiency and cold; Chills and pain of the waist and kness; Impotence and seminal emission; Frequent micturition; The enuresis; Failure of the kidney in receiving QI; Dyspnea due to deficiency is more than; Asthenia of both the spleen and kidney.Embodiment of the present invention taking dose is little, mouthfeel good, taking convenience absorbs comparatively fast, bioavailability is high, steady quality, production technology are simple.

Detailed description of the invention

Below in conjunction with specific embodiment, the invention will be further described, but not as limitation of the present invention.The part do not described in detail in the present embodiment adopts prior art, and industry standard or known approaches.

Embodiment

A kind of preparation method for the treatment of the Chinese medicine of chronic colitis it comprise the following steps:

1) by following weight weighting raw materials: Radix Aucklandiae (Radix Vladimiriae) 5g, Rhizoma Coptidis 5g, rhizoma corydalis 10g, Radix Paeoniae Alba 15g, Fructus Amomi 6g, Radix Glycyrrhizae 5g, Radix Pseudostellariae 30g, Endothelium Corneum Gigeriae Galli 15g, Fructus Psoraleae 15g, RADIX PUERARIAE 6g, the Flos Lonicerae 9g that speculates in golds, Poria 9g, Pericarpium Citri Reticulatae 3g, Cortex Phellodendri 3g, Rhizoma Zingiberis Preparatum carbon 2.4g, Halloysitum Rubrum 2g, Rhizoma Zingiberis 1g, Semen oryzae sativae 3g;

2) prepare the soak by water secondary that each component mixing of Chinese medicine adds 8 times amount more than in proportion, 2 hours first times, second time 1.5 hours, gradation filters, and merging filtrate, dusts with spray dryer, for subsequent use;

3) dry powder described in step 2 is added starch, anhydrous glucose, stevioside, mix homogeneously;

4) said mixture is added 80% ethanol soft material;

5) granulate with soft material 14 mesh sieve, arrange.

6) subpackage, put in storage.

Here is a kind of clinical observation for the treatment of the Chinese medicine of chronic colitis of the embodiment of the present invention:

1 data and method

1.1 physical data

Select to connect subject patients with chronic colitis 180 example voluntarily, man 94 example, female 86 example, at 31 ~ 63 years old age, 47 years old mean age, the course of disease is 0. 5 ~ 2 years.Be divided into treatment group 1, treatment group 2, treatment group 3, matched group at random, often organize 45 examples; Each group of patient age symptom is formed without significant difference.There is comparability (P>0.05).

1.2 Therapeutic Method

Treatment group Primary Care is consistent, and matched group is not taken medicine.Treatment group 1 embodiment of the present invention 1, every day three times, one time 2, within 30th, be a course for the treatment of.Treatment group 2 CHANGYANNING PIAN, Tianshikang Chinese Medicines Co., Ltd., Jiangxi produce, one time 4, every day 3 times; Treatment group 3 GUCHANG ZHIXIE WAN, Xi'an Efanggong Pharmaceutical Co., Ltd produces, a 4g, every day 3 times.

2 results

2.1 curative effect determinate standard

Recovery from illness: patient clinical transference cure, enteroscopy, intestinal mucosa inspection recover normal; Effective: patient clinical symptom alleviates, obviously improve before enteroscopy, intestinal mucosa pathological changes comparatively, stool routine examination inspection has a small amount of red, leukocyte; Take a turn for the better: patient clinical symptom alleviates to some extent, make moderate progress before enteroscopy, intestinal mucosa pathological changes comparatively, stool routine examination inspection has red, leukocyte; Invalid: before and after patient treatment, clinical symptoms and microscopy etc. check and do not improve or do not improve significantly.

2.2 therapeutic outcome

	Cure	Effective	Take a turn for the better	Invalid	Effective percentage
						Contrast				45	0
Treatment group 1	20	12	8	5	89%
						Treatment group 2	15	8	14	8	82%
Treatment group 3	12	10	12	11	76%

3 discuss

Treatment by Chinese herbs colitis of the present invention is evident in efficacy, and untoward reaction is little, few side effects, use safety, and clinic is promoted the use of.

Claims (1)

1. treat a Chinese medicine for chronic colitis, it is characterized in that the crude drug composition that it contains and weight proportion thereof are: Radix Aucklandiae (Radix Vladimiriae) 5 parts, Rhizoma Coptidis 5 parts, rhizoma corydalis 10 parts, Radix Paeoniae Alba 15 parts, Fructus Amomi 6 parts, 5 parts, Radix Glycyrrhizae, Radix Pseudostellariae 30 parts, Endothelium Corneum Gigeriae Galli 15 parts, Fructus Psoraleae 15 parts, RADIX PUERARIAE 6 parts, Flos Lonicerae 9 parts of speculating in golds, Poria 9 parts, Pericarpium Citri Reticulatae 3 parts, Cortex Phellodendri 3 parts, 2.4 parts, Rhizoma Zingiberis Preparatum carbon, Halloysitum Rubrum 2 parts, Rhizoma Zingiberis 1 part, Semen oryzae sativae 3 parts.