CN103055094B - Traditional Chinese medicine for treating leukemia and preparation method thereof - Google Patents
Traditional Chinese medicine for treating leukemia and preparation method thereof Download PDFInfo
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- CN103055094B CN103055094B CN201210573348.0A CN201210573348A CN103055094B CN 103055094 B CN103055094 B CN 103055094B CN 201210573348 A CN201210573348 A CN 201210573348A CN 103055094 B CN103055094 B CN 103055094B
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Abstract
The invention aims to provide a traditional Chinese medicine for treating leukemia and a preparation method thereof. The traditional Chinese medicine is prepared from the following raw materials: atrina glass, arnebia root, heydyotis, buffalo horn, clerodendroa cyrtophyllum, solanum nigrum, root bark of the peony tree, natural indigo and yam. The traditional Chinese medicine provided by the invention accords with the theory of traditional Chinese medicine, is scientific, reasonable, affordable and easily available, is closely targeted to pathogenesis and has the advantages of sufficient bases, reasonable compatibility of the raw materials, steady medicine properties and comprehensive effects. The traditional Chinese medicine for treating leukemia has a good therapeutic effect on leukemia, presents no toxic and side effects and is safe and reliable.
Description
Technical field
The present invention relates to field of medicaments, be specifically related to one and treat leukemic Chinese medicine and preparation method thereof.
Background technology
Leukemia is the abnormal clone's property malignant disease of a class hematopoietic stem cell.Leukaemia in its clone loses the ability of further differentiation and maturation and is stuck in cytocerastic different phase.In bone marrow and other hemopoietic tissue, a large amount of hypertrophy of leukaemia are gathered and infiltrate other Organ and tissues, make normal hematopoiesis suppressed simultaneously, and clinical manifestation is that anemia, hemorrhage, infection and each organ infiltrate symptom.
According to leukaemia's maturity and natural history, leukemia can be divided into acute and chronic two large classes.Acute leukemia is the malignant clone disease in the blood system in a class hematopoietic stem/progenitor cells source.Clinical infecting, hemorrhage, anemia and the outer histoorgan of marrow infiltrate as main manifestations, disease progression is rapid, natural history only has several weeks to the several months.Generally can be divided into acute myeloid leukemia (AML) and the large class of acute lymphoblastic leukemia (ALL) two according to leukaemia's series ownership.The feature of chronic leukemia is the cell hyperplasia of differentiation and maturation that has function, therefore chronic white blood should be a kind of due to signal conduction is bad or uncontrolled cellular proliferation due to illness, but not due to dysmaturity.Chronic leukemia is common chronic myelocytic leukemia (CML), chronic lymphocytic leukemia (CLL).
At present, the treatment means of acute leukemia mainly contains chemotherapy, bone marrow transplantation.Chemotherapeutical object is remove leukemic clone and rebuild bone marrow normal hematopoiesis function.Chemotherapy is palliating leukemia effectively, extends patient's life span.But chemotherapy also has very high drug toxicity, bring multiple serious adverse reaction, such as health is weak, immunologic function degression, bone marrow depression, gastricism, inflammatory reaction, cardiac toxicity, Toxicity of Kidney, phlebitis, nervous system toxicity, hepatotoxicity, cystitis etc.
Bone marrow transplantation is applicable to save Induction failure, early stage recurrence or some high-risk patient, approximately 60% Adults with Acute Leukemia, and process allogene or isogeneic bone marrow transplantation can reach 3 years and grow above life cycle, and part has reached more than 5～6 years.But it need have the allosome bone marrow of inputting for marrow person of the affinity-less relation of the sib that matches with patient human leukocyte antigen (HLA) and only a few bone marrow transplantation, or between kinsfolk as father and mother and children's bone marrow transplantation; And the unrelated donor's of not bery mating with patient HLA bone marrow.Though non-compatriot's siblings HLA matches, easily there is the graft versus host disease (GVHD) that weight does not wait, especially more serious at latter event.
In prior art, utilize in addition target administration, kill the Therapeutic Method of leukemia clone cell, still in development period, apply extensive not at present.Traditional Chinese medical herbal treatment leukemia also in recent years more research, but treatment by Chinese herbs leukemia lacks systematic clinical research, and curative effect is definite not.
Summary of the invention
The object of this invention is to provide one and treat leukemic Chinese medicine and preparation method thereof, the leukemic Chinese medicine for the treatment of provided by the present invention can be treated leukemia preferably, has no side effect, safe and reliable.
The leukemic Chinese medicine for the treatment of of the present invention is to be prepared from by the raw material that comprises following weight portion:
Herba Patriniae 20～80 Radix Arnebiae (Radix Lithospermi) 10～50 Herba Hedyotidis Diffusaes 10～50
Cornu Bubali 10～50 Folium Isatidis 10～50 Herba Solani Nigris 5～30
Cortex Moutan 5～30 Indigo Naturalis 2～10 Rhizoma Dioscoreaes 5～30.
The leukemic Chinese medicine for the treatment of of the present invention, its preferred version is to be prepared from by the raw material that comprises following weight portion:
Herba Patriniae 40～70 Radix Arnebiae (Radix Lithospermi) 20～40 Herba Hedyotidis Diffusaes 20～40
Cornu Bubali 20～40 Folium Isatidis 20～40 Herba Solani Nigris 10～20
Cortex Moutan 20～40 Indigo Naturalis 4～8 Rhizoma Dioscoreaes 10～20.
The leukemic Chinese medicine for the treatment of of the present invention, its further preferred version is to be prepared from by the raw material that comprises following weight portion:
Herba Patriniae 50 Radix Arnebiae (Radix Lithospermi) 30 Herba Hedyotidis Diffusaes 30
Cornu Bubali 30 Folium Isatidis 30 Herba Solani Nigris 12
Cortex Moutan 12 Indigo Naturalis 6 Rhizoma Dioscoreaes 12.
The leukemic Chinese medicine for the treatment of of the present invention, its active component is prepared from by the following method:
Get whole 9 taste medical materials, extracting in water twice, adds the water that is equivalent to 6～12 times of medical material gross weights for the first time, extracts 1～3 hour, adds for the second time the water that is equivalent to 6～12 times of medical material gross weights, extracts 1～2 hour; Merge extractive liquid,, the extractum that while being concentrated into 80 ℃, relative density is 1.20～1.30, adding ethanol to the concentration of volume percent containing alcohol amount is 50%～60%, stir even, standing 12～24 hours, filter, the extractum that when filtrate is concentrated into 80 ℃, relative density is 1.24～1.30, obtains described active component.
The leukemic Chinese medicine for the treatment of of the present invention, its active component is to be prepared from by following method for optimizing:
Get whole 9 taste medical materials, extracting in water twice, adds the water that is equivalent to 8～10 times of medical material gross weights for the first time, extracts 2 hours, adds for the second time the water that is equivalent to 8～10 times of medical material gross weights, extracts 1.5 hours; Merge extractive liquid,, the extractum that while being concentrated into 80 ℃, relative density is 1.23, adding ethanol to the concentration of volume percent containing alcohol amount is 56%, stir even, standing 12～24 hours, filter, the extractum that when filtrate is concentrated into 80 ℃, relative density is 1.28, obtains described active component.
The leukemic Chinese medicine for the treatment of of the present invention, can coordinate with pharmaceutically acceptable carrier, makes various common dosage forms.
In the present invention, Chinese medicine details is as follows:
Herba Patriniae
This product is Herba Patriniae section plant Hemerocallis citrina Baroni dragon bud Patrinia scabiosaefolia Fisch. ex Link., and patrima villosa (bitter vegetarian) P. villosa (Thunb.) Juss., with root stock and root, all herbal medicine.Root is excavated season in spring and autumn, removes stem and leaf and cleans, and dries.Autumn in herb summer taps, and cleans and dries.Acrid in the mouth, hardship, cool in nature.Enter stomach, large intestine, Liver Channel.Function heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, blood circulation promoting competent silt.For acute appendicitis, lung abscess and sore and toxic, the breast abdomen pain due to the excess-heat stasis of blood is stagnant, the diseases such as the stagnant stomachache of the stasis of blood in puerperal.
Radix Arnebiae (Radix Lithospermi)
The dry root of comfrey lithospermum euchromum Royle Arnebia euchroma (Royle) Johnst., Radix Arnebiae (Radix Lithospermi) Lithospermum erythrorhizon Sieb .et Zucc. or arnebia guttata Bunge Arnebia guttata Bunge.Spring, Qiu Erji excavate, and remove silt, dry.Sweet in the mouth, salty, cold in nature.GUIXIN, Liver Channel.Function clearing away heat and cooling blood, promoting blood circulation and detoxication, rash speckle removing.For heat in blood poison, contain, macule purple is black, measles without adequate eruption, skin infection, eczema, burn due to hot liquid or fire.
Herba Hedyotidis Diffusae
This product is the dry herb of Maguireothamnus speciosus Herba Hedyotidis Diffusae Hedyotis diffusa Willd..Summer, two seasons of autumn excavate, and remove impurity, clean, and dry.Mildly bitter flavor, micro-sweet, cold nature.GUIXIN, liver, spleen channel.Function heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, inducing diuresis to remove edema.For laryngopharynx swelling and pain, dyspnea and cough due to lung-heat, the puckery pain of pyretic stranguria, jaundice due to damp-heat, venom, the skin ulcer hot carbuncle that swells.
Cornu Bubali
This product is the angle of bovid Babalus bubalis L. Bubalus bubalis Linnaeus.Bitter in the mouth is salty, cold in nature.Enter the heart, liver, spleen, stomach four warps.Function heat clearing away, removing heat from blood, removing toxic substances.Control calentura headache, high fever coma, macule, tells nosebleed, infantile convulsion, sore throat pharyngeal swelling.
Folium Isatidis
This product is the dried leaves of cruciferae isatis Isatis indigotica Fort..Divide in summer, two seasons of autumn and gather for 2～3 times, remove impurity, dry.Bitter in the mouth, cold in nature.GUIXIN, stomach warp.Function heat-clearing and toxic substances removing, blood cooling and ecchymoses removing.For the high heat of epidemic febrile disease, coma, sends out speckle dermexanthesis, mumps, sore throat, erysipelas, carbuncle.
Herba Solani Nigri
This product be plant of Solanaceae Herba Solani Nigri Solanum nigrum L. herb.Summer, autumn tap, and remove impurity, dry.Bitter in the mouth, cold in nature, slightly poisonous.Function heat-clearing and toxic substances removing, inducing diuresis to remove edema.For cat fever, toothache, chronic bronchitis, acute nephritis, dysentery, urinary system infection, mastitis, leucorrhea, cancer; Carbuncle furuncle furuncle, pemphigus, injury from falling down, venom are controlled in external.
Cortex Moutan
The dry root bark of ranunculaceae peony Paeonia suffruticosa Andr..Excavate root autumn, remove radicula and silt, strip root bark, dry or scrape off rough bark, remove core, dry.The former practises and claims to connect Cortex Moutan, and the latter practises and claims to scrape Cortex Moutan.Bitter in the mouth, pungent, cold nature.GUIXIN, liver, kidney channel.Function clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling.For thermal man's nutrient blood, maculae caused by violent heat pathogen, hematemesis and epistaxis, night fever abating at dawn, lossless hectic fever due to YIN-deficiency, amenorrhea dysmenorrhea, falls and flutters the pain of injury, carbuncle sore tumefacting virus.
Indigo Naturalis
The dried powder, agglomerate or the granule that through processing, make for the leaf of acanthaceous vegetable acanthaceous indigo Baphicacanthus cusia (Nees) Bremek., polygonaceae plant polygonum tinctorium ait. Polygonum tinctorium Ait. or cruciferae isatis Isatis indigotica Fort. or stem and leaf.Salty in the mouth, cold in nature.Return Liver Channel.Function heat-clearing and toxic substances removing, blood cooling and ecchymoses removing, pathogenic fire purging arresting convulsion.For maculae caused by violent heat pathogen, heat in blood is told nosebleed, chest pain hemoptysis, aphtha, mumps, sore throat, pediatric epilepsy scared.
Rhizoma Dioscoreae
These product are the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae Dioscorea opposita.Sweet in the mouth, property is flat.Return spleen, lung, kidney channel.Function spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission.For insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, and leukorrhagia, frequent micturition, deficiency-heat is quenched one's thirst.
The present invention finds out on to the basis of leukemia basic pathogenesis full appreciation.Acute leukemia is take heating, hemorrhage, leucocytosis as main clinical manifestation, so Herba Patriniae, heat clearing and blood cooling removing toxic substances for the present invention; Coordinate Radix Arnebiae (Radix Lithospermi), Cornu Bubali, Folium Isatidis, Cortex Moutan, cooling blood for hemostasis; Herba Hedyotidis Diffusae, Indigo Naturalis, the anticancer removing toxic substances of Herba Solani Nigri heat-clearing and toxic substances removing, treating the poisonous disease with poisonous drugs; Rhizoma Dioscoreae is protected spleen kidney.Ingredients of the present invention, differs from one another, and rushes down benefit combination, brings out the best in each other.The present invention meets theory of Chinese medical science, scientific and reasonable, economic and practical, easy being easy to get, and the pathogenesis that links closely, according to abundant, compatibility is reasonable, and the property of medicine is steady, and effect is comprehensively.
As the clinical test results of embodiment 6 and embodiment 7 shows, treatment by Chinese herbs leukemia of the present invention, has good effect, and effective percentage reaches 70%; And in the clinical process treating, have no toxic and side effects, safe and reliable.
Chinese medicine provided by the invention has overcome the defect of prior art, with respect to prior art, has outstanding substantive distinguishing features and progressive significantly.
The specific embodiment
Embodiment 1
Herba Patriniae 200g Radix Arnebiae (Radix Lithospermi) 100g Herba Hedyotidis Diffusae 100g
Cornu Bubali 100g Folium Isatidis 100g Herba Solani Nigri 50g
Cortex Moutan 50g Indigo Naturalis 20g Rhizoma Dioscoreae 50g
Get whole 9 taste medical materials, extracting in water twice, adds the water of 4620g for the first time, extracts 1 hour, adds for the second time the water of 4620g, extracts 1 hour; Merge extractive liquid,, the extractum that while being concentrated into 80 ℃, relative density is 1.20, adding ethanol to the concentration of volume percent containing alcohol amount is 50%, stir even, standing 12 hours, filter, the extractum that when filtrate is concentrated into 80 ℃, relative density is 1.24, obtains described active component.
Embodiment 2
Herba Patriniae 800g Radix Arnebiae (Radix Lithospermi) 500g Herba Hedyotidis Diffusae 500g
Cornu Bubali 500g Folium Isatidis 500g Herba Solani Nigri 300g
Cortex Moutan 300g Indigo Naturalis 100g Rhizoma Dioscoreae 300g
Get whole 9 taste medical materials, extracting in water twice, adds the water of 45600g for the first time, extracts 3 hours, adds for the second time the water of 45600g, extracts 2 hours; Merge extractive liquid,, the extractum that while being concentrated into 80 ℃, relative density is 1.30, adding ethanol to the concentration of volume percent containing alcohol amount is 60%, stir even, standing 24 hours, filter, the extractum that when filtrate is concentrated into 80 ℃, relative density is 1.30, obtains described active component.
Active component is mixed with appropriate sucrose, granulation, dry, obtain granule of the present invention.
Embodiment 3
Herba Patriniae 400g Radix Arnebiae (Radix Lithospermi) 200g Herba Hedyotidis Diffusae 200g
Cornu Bubali 200g Folium Isatidis 200g Herba Solani Nigri 100g
Cortex Moutan 200g Indigo Naturalis 80g Rhizoma Dioscoreae 200g
Get whole 9 taste medical materials, extracting in water twice, adds the water of 12460g for the first time, extracts 2 hours, adds for the second time the water of 16020g, extracts 1.5 hours; Merge extractive liquid,, the extractum that while being concentrated into 80 ℃, relative density is 1.22, adding ethanol to the concentration of volume percent containing alcohol amount is 55%, stir even, standing 18 hours, filter, the extractum that when filtrate is concentrated into 80 ℃, relative density is 1.25, obtains described active component;
Active component is mixed with appropriate sucrose and antiseptic, add water to 1000g, obtain oral liquid of the present invention.
Embodiment 4
Herba Patriniae 500g Radix Arnebiae (Radix Lithospermi) 300g Herba Hedyotidis Diffusae 300g
Cornu Bubali 300g Folium Isatidis 300g Herba Solani Nigri 120g
Cortex Moutan 120g Indigo Naturalis 60g Rhizoma Dioscoreae 120g
Get whole 9 taste medical materials, extracting in water twice, adds the water of 16960g for the first time, extracts 2.5 hours, adds for the second time the water of 19080g, extracts 1.8 hours; Merge extractive liquid,, the extractum that while being concentrated into 80 ℃, relative density is 1.23, adding ethanol to the concentration of volume percent containing alcohol amount is 56%, stir even, standing 20 hours, filter, the extractum that when filtrate is concentrated into 80 ℃, relative density is 1.28, obtains described active component.
Active component is mixed with appropriate amount of starch and dextrin, granulate, dry, tabletting, obtains tablet of the present invention.
Embodiment 5
Herba Patriniae 400g Radix Arnebiae (Radix Lithospermi) 400g Herba Hedyotidis Diffusae 400g
Cornu Bubali 400g Folium Isatidis 400g Herba Solani Nigri 180g
Cortex Moutan 400g Indigo Naturalis 70g Rhizoma Dioscoreae 160g
Get whole 9 taste medical materials, extracting in water twice, adds the water of 30910g for the first time, extracts 2.3 hours, adds for the second time the water of 19670g, extracts 1.3 hours; Merge extractive liquid,, the extractum that while being concentrated into 80 ℃, relative density is 1.28, adding ethanol to the concentration of volume percent containing alcohol amount is 59%, stir even, standing 12～24 hours, filter, the extractum that when filtrate is concentrated into 80 ℃, relative density is 1.26, obtains described active component.
Active component is put in vacuum drying oven to 70 ℃ and dry, pulverize 100 mesh sieves, add appropriate amount of starch, silicon dioxide, magnesium stearate, granulation, dry, incapsulate, obtain capsule of the present invention.
Embodiment 6
The clinical trial situation of Chinese medicine of the present invention:
Case selection: treat at random leukemia 42 examples, 21 days mean treatment time;
Therapeutic Method: take the Chinese medicine of the embodiment of the present invention 4, every day twice, each serving the medicine with being equivalent to crude drug amount 106g;
Table 1 is treated clinical efficacy data
| ? | Number of cases | Clinical effective | Clinical effective | Invalid | Total effective rate |
| Embodiment 4 | 42 | 18 | 11 | 13 | 70% |
Embodiment 7
1, open × ×, man, 47 years old, Guangxi San Jiangxian people, made a definite diagnosis leukemia 1 month, and disease sees that heating do not move back, epistaxis, spiritlessness and weakness, complexion is sent out red, and polylogia is multi-lingual, thirsty yellowish urine, constipation with dry stool, red tongue with yellow fur is thick, wiry and frequent pulse; Leukocyte 76 X 109/L.After being in hospital, through medicine of the present invention, treat, treat after heat in 7 days and only move back blood, leukocyte 26 X 109/L.Continuous use 21 days, stable disease, leukocyte 9.4 X 109/L.Rear Multiple Hospitalization, all take we as main, obtains clinical remission.
2, Liu × ×, man, 46 years old, people from Liuzhou city, Guangxi province, made a definite diagnosis leukemia 5 months, weak effect after chemotherapy, side effect is obvious, requires traditional Chinese medical science clinic treatment.Adstante febre is done, subcutaneous purpura, and stool band blood, spiritlessness and weakness, complexion is sent out red, thirsty yellowish urine, red tongue with yellow fur is thick, wiry and frequent pulse; Leukocyte 25 X 109/L.After being in hospital, through medicine of the present invention, treat, every day, potion, treated March, and heat is only moved back blood, mental restoration, and leukocyte 5 X 109/L obtain clinical remission.Recurrence that so far there are no.
3, open ×, female, 20 years old, Rongshui Guangxi people from county, made a definite diagnosis leukemia 1 year, recurs 1 month.Disease sees that heating do not move back, hematemesis and epistaxis, and pale complexion, thirsty yellowish urine, has a dizzy spell, and red tongue with yellow fur is thick, thready and rapid pulse; Leukocyte 24 X 109/L.After being in hospital, through medicine of the present invention, treat, treat after heat in 10 days and only move back blood, leukocyte 12 X 109/L.Continuous use 14 days, stable disease, leukocyte 6.4 X 109/L.So far still in treatment.
Claims (5)
1. the leukemic Chinese medicine for the treatment of, is characterized in that it is to be prepared from by the raw material of following weight portion:
Herba Patriniae 20～80 Radix Arnebiae (Radix Lithospermi) 10～50 Herba Hedyotidis Diffusaes 10～50
Cornu Bubali 10～50 Folium Isatidis 10～50 Herba Solani Nigris 5～30
Cortex Moutan 5～30 Indigo Naturalis 2～10 Rhizoma Dioscoreaes 5～30.
2. the leukemic Chinese medicine for the treatment of as claimed in claim 1, is characterized in that it is to be prepared from by the raw material of following weight portion:
Herba Patriniae 50 Radix Arnebiae (Radix Lithospermi) 30 Herba Hedyotidis Diffusaes 30
Cornu Bubali 30 Folium Isatidis 30 Herba Solani Nigris 12
Cortex Moutan 12 Indigo Naturalis 6 Rhizoma Dioscoreaes 12.
3. the leukemic Chinese medicine for the treatment of as claimed in claim 1, is characterized in that its active component is prepared from by the following method:
Get whole 9 taste medical materials, extracting in water twice, adds the water that is equivalent to 6～12 times of medical material gross weights for the first time, extracts 1～3 hour, adds for the second time the water that is equivalent to 6～12 times of medical material gross weights, extracts 1～2 hour; Merge extractive liquid,, the extractum that while being concentrated into 80 ℃, relative density is 1.20～1.30, adding ethanol to the concentration of volume percent containing alcohol amount is 50%～60%, stir even, standing 12～24 hours, filter, the extractum that when filtrate is concentrated into 80 ℃, relative density is 1.24～1.30, obtains described active component.
4. the leukemic Chinese medicine for the treatment of as claimed in claim 1, is characterized in that its active component is prepared from by the following method:
Get whole 9 taste medical materials, extracting in water twice, adds the water that is equivalent to 8～10 times of medical material gross weights for the first time, extracts 2 hours, adds for the second time the water that is equivalent to 8～10 times of medical material gross weights, extracts 1.5 hours; Merge extractive liquid,, the extractum that while being concentrated into 80 ℃, relative density is 1.23, adding ethanol to the concentration of volume percent containing alcohol amount is 56%, stir even, standing 12～24 hours, filter, the extractum that when filtrate is concentrated into 80 ℃, relative density is 1.28, obtains described active component.
5. the leukemic Chinese medicine preparation for the treatment of, comprises the leukemic Chinese medicine of the treatment of any one in claim 1～4 and pharmaceutically acceptable carrier.
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