CN104491396A - Traditional Chinese medicine preparation for treating radiation stomatitis - Google Patents
Traditional Chinese medicine preparation for treating radiation stomatitis Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating radiation stomatitis. The traditional Chinese medicine preparation is prepared from the following medicinal materials in parts by weight: 10 to 20g of coptis chinensis, 10 to 20g of radices trichosanthis, 10 to 20g of astragalus membranaceus, 10 to 20g of honeysuckle, 10 to 20g of radix glehniae, 10 to 20g of radix ophiopogonis, 10 to 20g of bark of tree peony root, 10 to 20g of salvia miltiorrhiza, 10 to 20g of rhizoma atractylodis macrocephalae, 5 to 15g of radix bupleuri, and 5 to 15g of liquorice. According to the traditional Chinese medicine preparation, the medicinal materials are combined well and treat both symptoms and root causes, and the advantage of selection of treatment based on the differential diagnosis of traditional Chinese medicine is played into full; the traditional Chinese medicine preparation is used for preventing and treating radiation stomatitis, has the effects of clearing heat and removing toxicity, nourishing Yin and generating body fluid, cooling blood and activating blood circulation, and invigorating spleen and replenishing Qi, achieves the effect of removing aphthous stomatitis, and is worthy of popularization and application.
Description
Technical field
The invention belongs to the field of Chinese medicines, specifically a kind of Chinese medicine preparation can preventing and treating Inflammation of Radioactive Oral Cavity.
Background technology
Inflammation of Radioactive Oral Cavity is scorching or radiotherapy-induced oral mucositis also known as radioactivity oropharynx, and be a kind of acute and chronic oral mucosa damage of radioactive ionization radiation, belong to the complication of head-cervical radiotherapy, its incidence rate is about 46.0% ~ 78.1%.In the Patients During Radiotherapies such as Nasopharyngeal Malignant Lymphoma, nasopharyngeal carcinoma, mouth neoplasm, often there will be radiation injury.Because mucosal epithelial cells is more responsive to lonizing radiation, so Inflammation of Radioactive Oral Cavity is complication common in Patients During Radiotherapy, be cause the reason that Patients Treated by Radiotherapy interrupts and even control is failed.
At present, doctor trained in Western medicine to the prevention and therapy of acute radiation oral mucositis also without specific medicament, adopt megavitamin, high-protein nutrient and the treatment such as fluid infusion, antiinflammatory more, and award locally sprayed or Wisk topical spray of oral cavity cleaning, lignocaine local anesthesia, watermelon crystal etc., but how unsatisfactory curative effect is simultaneously.According to the principle of Chinese medical discrimination control, treating both the principal and the secondary aspects of a disease at the same time, we providing a kind of Chinese medicine preparation, achieving satisfied effect for preventing and treating Inflammation of Radioactive Oral Cavity.
Summary of the invention
Instant invention overcomes and at present preventing and treating the technical deficiency existed in Inflammation of Radioactive Oral Cavity, provide a kind of evident in efficacy, cheap, Chinese medicine preparation that patient is easy to the treating radioactive stomatitis accepted.
The technical solution adopted in the present invention is:
A Chinese medicine preparation for treating radioactive stomatitis, is characterized in that, described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
Rhizoma Coptidis 10-20 gram, Radix Trichosanthis 10-20 gram, Radix Astragali 10-20 gram, Flos Lonicerae 10-20 gram, Radix Glehniae 10-20 gram, Radix Ophiopogonis 10-20 gram, Cortex Moutan 10-20 gram, Radix Salviae Miltiorrhizae 10-20 gram, Rhizoma Atractylodis Macrocephalae 10-20 gram, Radix Bupleuri 5-15 gram, Radix Glycyrrhizae 5-15 gram.
As this kind of prioritization scheme:
Described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
Rhizoma Coptidis 10 grams, Radix Trichosanthis 10 grams, the Radix Astragali 10 grams, Flos Lonicerae 10 grams, Radix Glehniae 10 grams, Radix Ophiopogonis 10 grams, Cortex Moutan 10 grams, Radix Salviae Miltiorrhizae 10 grams, the Rhizoma Atractylodis Macrocephalae 10 grams, Radix Bupleuri 5 grams, 5 grams, Radix Glycyrrhizae.
As this kind of prioritization scheme:
Described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
Rhizoma Coptidis 15 grams, Radix Trichosanthis 15 grams, the Radix Astragali 15 grams, Flos Lonicerae 15 grams, Radix Glehniae 15 grams, Radix Ophiopogonis 15 grams, Cortex Moutan 15 grams, Radix Salviae Miltiorrhizae 15 grams, the Rhizoma Atractylodis Macrocephalae 15 grams, Radix Bupleuri 10 grams, 10 grams, Radix Glycyrrhizae.
As this kind of prioritization scheme:
Described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
Rhizoma Coptidis 20 grams, Radix Trichosanthis 20 grams, the Radix Astragali 20 grams, Flos Lonicerae 20 grams, Radix Glehniae 20 grams, Radix Ophiopogonis 20 grams, Cortex Moutan 20 grams, Radix Salviae Miltiorrhizae 20, the Rhizoma Atractylodis Macrocephalae 20 grams, Radix Bupleuri 15 grams, 15 grams, Radix Glycyrrhizae.
The instructions of taking of Chinese medicine preparation of the present invention is: after being mixed by the raw material Chinese medicine of above-mentioned weight proportion, 1 dose/day, every agent head decocts the 600ml that adds water, and slow fire boils 30 minutes, extracting juice 300ml; Two decoct the 400ml that adds water, and slow fire boils 20 minutes, extracting juice 200ml.Two decoct mixing, are concentrated into 200ml, each 30ml, and every day, buccal 6 times, swallowed after each rinsing the mouth 15min slowly, forbid drinking-water, with terminating latter 7 days to radiotherapy after taking medicine in 30min.
The raw material Chinese medicine of above-mentioned Chinese medicine preparation:
Rhizoma Coptidis: bitter in the mouth, cold in nature.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.There is heat clearing and damp drying, effect of eliminating fire and detoxication.
Radix Trichosanthis: sweet in the mouth, micro-hardship, cold nature.Attach to the lung and stomach meridians.There is clearing away heat-fire, promoting the production of body fluid to quench thirst, effect of detumescence and apocenosis.
The Radix Astragali: sweet in the mouth, slightly warm in nature.Return lung, spleen channel.There is tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, promote the production of body fluid and nourish blood, the stagnant blood stasis dispelling of row, expelling pus and toxin by strengthening QI, effect of expelling pus and promoting granulation.
Flos Lonicerae: sweet in the mouth, cold in nature.Return lung, the heart, stomach warp.There is heat-clearing and toxic substances removing, effect of dispelling wind and heat pathogens.
Radix Glehniae: sweet in the mouth, micro-hardship, cold nature.Attach to the lung and stomach meridians.There is nourishing YIN and clearing away lung-heat, effect of reinforcing stomach reg fluid.
Radix Ophiopogonis: sweet in the mouth, micro-hardship, cold nature.GUIXIN, lung, stomach warp.There is YIN nourishing and the production of body fluid promoting, effect that lung moistening clears away heart-fire.
Cortex Moutan: bitter in the mouth, pungent, is slightly cold.GUIXIN, liver, kidney channel.There is clearing away heat and cooling blood, effect of blood circulation promoting and blood stasis dispelling.
Radix Salviae Miltiorrhizae: bitter in the mouth, is slightly cold.GUIXIN, Liver Channel.Have blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia, clear away heart-fire relieving restlessness, effect of removing heat from blood eliminating carbuncle.
The Rhizoma Atractylodis Macrocephalae: bitter in the mouth, sweet, warm in nature.Return spleen, stomach warp.There is invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive effect.
Radix Bupleuri: acrid in the mouth, hardship, cold nature.Return liver, gallbladder, lung meridian.There is evacuation bring down a fever, dispersing the stagnated live-QI to relieve the stagnation of QI, effect of elevate a turnable ladder yang-energy.
Radix Glycyrrhizae: sweet in the mouth, property is put down.GUIXIN, lung, spleen, stomach warp.There is invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, effect of coordinating the actions of various ingredients in a prescription.
Inflammation of Radioactive Oral Cavity belongs to the traditional Chinese medical science " erosion of the oral mucosa " category, because lonizing radiation belong to the heresy of fire-toxin, easy injury-gas consumption, the caused damage in lonizing radiation direct irradiation oral cavity is that burning hot malicious heresy burns bright skin, the most basic pathological change is deficiency of both QI and YIN, and common pattern of syndrome has excessive noxious heat, hyperactivity of fire caused by deficiency of YIN, deficiency of both QI and YIN, insufficiency of the spleen damp and hot, qi depression to blood stasis and blood stasis due to qi deficiency etc.Current modern medicine is still not fully aware of for the mechanism of acute radioactivity stomatitis treated, think it may is oral cavity normal mucosa coefficient result of many factors under the irradiation of lonizing radiation, comprise salivation minimizing that the mode of irradiation and dosage, self-resistance, oral disease and sanitary condition, radiotherapy causes, autoimmunity that oral cavity self-cleaning action disappearance, radiotherapy cause declines, oral cavity flora imbalance etc. that chemotherapeutics causes the damage of active proliferation mucosa cells and hemopoietic system and immunological function repression, use antibiotic.Therefore prevent and treat primary disease to show according to patient's different symptoms, with heat-clearing and toxic substances removing, YIN nourishing and the production of body fluid promoting, removing heat from blood and promoting blood circulation or air making-up and spleen enlivening for method for the treatment of, fundamentally adjust body hormonal system, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, applies in a flexible way, and Fang Xianqi is imitated.
In Chinese medicine preparation of the present invention, Rhizoma Coptidis, Radix Trichosanthis, Flos Lonicerae, Radix Bupleuri can heat-clearing and toxic substances removing, dispelling wind and heat pathogens; Radix Glehniae, Radix Ophiopogonis can YIN nourishing and the production of body fluid promoting; Cortex Moutan, Radix Salviae Miltiorrhizae can clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling; The Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae can invigorating the spleen and replenishing QI.Full side's compatibility is superior, treating both the principal and secondary aspects of a disease, having given full play to the advantage that differential diagnosis in tcm treats, for preventing and treating Inflammation of Radioactive Oral Cavity, having had heat-clearing and toxic substances removing, YIN nourishing and the production of body fluid promoting, removing heat from blood and promoting blood circulation, the merit of invigorating the spleen and replenishing QI, to reach the effect of elimination " erosion of the oral mucosa ", and clinic promotion and application.
For investigating clinical efficacy and the safety of medicine of the present invention further, we select certain hospital all to make a definite diagnosis through cytology or histopathology, for radiating the routine patient of head-neck malignant tumor case 60 of control first, minimum 25 years old of age, maximum 64 years old, average 41.5 years old, be divided into and prevent and treat group and (take each 30ml of invention formulation, every day, buccal 6 times, swallowed after each rinsing the mouth 15min slowly, forbade drinking-water after taking medicine in 30min.With terminating latter 7 days to radiotherapy) and matched group (radiotherapy starts front 30min and takes dioctahedral smectite, with 30ml boiled water dissolve after buccal, every day, buccal 6 times, swallowed after rinsing the mouth 15min slowly, forbid in 30min after taking medicine drinking-water.With terminating latter 7 days to radiotherapy.) carry out clinical trial.
Inflammation of Radioactive Oral Cavity is according to RTOG acute radiation injury grade scale:
0 grade: unchanged.
I grade: mild pain; Oral mucosa is congested, go out erythema.
II grade: moderate pain, energy influent stream matter; Lamellar oral mucositis, rheuminess thing, edema or ulcer.
III grade: severe pain, dysphagia; The fibroid mucositis that oral mucosa merges, edema, ulcer.
IV grade: severe pain, can not take food; Stomatocace is hemorrhage, downright bad.
Criterion of therapeutical effect: effective: possess following standard 3 ~ 4; Effective: to possess following standard 1 ~ 2; Invalid: not possess following standard.
1. pain obviously alleviates or eliminates.2. redness obviously alleviates or disappears.3. ulcer surface maximum gauge reduce >=1/3; Ulcer decreased number >=1/2.4. ulcer healed in 1 week.
Prevention and controls:
After being mixed by the raw material Chinese medicine of above-mentioned weight proportion, add water fried, every agent head decocts the 600ml that adds water, and warm fire boils 30 minutes, extracting juice 300ml; Two decoct the 400ml that adds water, and slow fire boils 20 minutes, extracting juice 200ml.Two decoct mixing, are concentrated into 200ml, each 20 ~ 30ml, and every day, buccal 4 ~ 6 times, swallowed after each rinsing the mouth 15min slowly, forbid drinking-water, with terminating latter 10 days to radiotherapy after taking medicine in 30min.
Efficacy result:
1. clinical efficacy result:
Prevent and treat group: effective 20 examples, effective 8 examples, invalid 2 examples, effective percentage is 93.3%; Matched group: effective 8 examples, effective 12 examples, invalid 10 examples, effective percentage is 66.7%; Detailed results is in table 1.
Rear clinical efficacy result table prevented and treated by table 1
| Group | Number of cases | Effective n | Effective n | Invalid n | Effective percentage (%) |
| Prevent and treat group | 30 | 20 | 8 | 2 | 93.3 |
| Matched group | 30 | 8 | 12 | 10 | 66.7 |
2. side effect reaction
In control, all there is not obvious adverse reaction in all patients.
Result shows, Chinese medicine preparation of the present invention, by Chinese medicine differential diagnosis of diseases and the dialectical principle combined, is attacked and mended double making, treating both the principal and the secondary aspects of a disease at the same time, evident in efficacy for preventing and treating Inflammation of Radioactive Oral Cavity, clinic promotion and application.
Detailed description of the invention
Embodiment 1: a kind of Chinese medicine preparation for the treatment of radioactive stomatitis, chooses Rhizoma Coptidis 10 grams, Radix Trichosanthis 10 grams, the Radix Astragali 10 grams, Flos Lonicerae 10 grams, Radix Glehniae 10 grams, Radix Ophiopogonis 10 grams, Cortex Moutan 10 grams, Radix Salviae Miltiorrhizae 10 grams, the Rhizoma Atractylodis Macrocephalae 10 grams, Radix Bupleuri 5 grams, 5 grams, Radix Glycyrrhizae.
Embodiment 2: a kind of Chinese medicine preparation for the treatment of radioactive stomatitis, chooses Rhizoma Coptidis 15 grams, Radix Trichosanthis 15 grams, the Radix Astragali 15 grams, Flos Lonicerae 15 grams, Radix Glehniae 15 grams, Radix Ophiopogonis 15 grams, Cortex Moutan 15 grams, Radix Salviae Miltiorrhizae 15 grams, the Rhizoma Atractylodis Macrocephalae 15 grams, Radix Bupleuri 10 grams, 10 grams, Radix Glycyrrhizae.
Embodiment 3: a kind of Chinese medicine preparation for the treatment of radioactive stomatitis, chooses Rhizoma Coptidis 20 grams, Radix Trichosanthis 20 grams, the Radix Astragali 20 grams, Flos Lonicerae 20 grams, Radix Glehniae 20 grams, Radix Ophiopogonis 20 grams, Cortex Moutan 20 grams, Radix Salviae Miltiorrhizae 20 grams, the Rhizoma Atractylodis Macrocephalae 20 grams, Radix Bupleuri 15 grams, 15 grams, Radix Glycyrrhizae.
Below by concrete case, Chinese medicine preparation curative effect of the present invention is verified further:
Case 1
Zhang, women, 41 years old.Suffer from nasopharyngeal carcinoma, occur xerostomia after radiotherapy, companion's pharyngalgia, ulcer around oral cavity, bicker ulceration, can only drink liquid food.Take Chinese medicine preparation described in the embodiment of the present invention 1 upon somebody's introduction to treat, take medicine 10 doses, without uncomfortable.Serve on 1 month, ulcer around pharyngalgia, oral cavity, the transference cures such as bicker ulceration.
Case 2
Shut out so-and-so, man, 56 years old.Suffer from laryngeal carcinoma, radiation period is taken Chinese medicine preparation described in the embodiment of the present invention 1 and is prevented and treated, and oral cavity mouth mucosa is slightly congested, has no obvious pain.
Case 3
Yang, female, 47 years old.Suffer from thyroid carcinoma, after radiotherapy, oral cavity pain is obvious, dysphagia; Oral mucosa edema, ulcer.To Chinese medicine preparation described in the embodiment of the present invention 2, readme symptom after a week of taking medicine obviously alleviates, and continues to take 1 month altogether with medicine of the present invention, and pain obviously alleviates, and the recovery from illness of ulcer, edema, can normally take food.
Case 4
Grandson so-and-so, female, 38 years old.Suffer from carcinoma of tongue, radiation period is taken Chinese medicine preparation described in the embodiment of the present invention 3 and is prevented and treated, and oral cavity mouth mucosa is slightly congested, has erythema, mild pain, can influent stream matter.
Claims (4)
1. a Chinese medicine preparation for treating radioactive stomatitis, is characterized in that, described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
Rhizoma Coptidis 10-20 gram, Radix Trichosanthis 10-20 gram, Radix Astragali 10-20 gram, Flos Lonicerae 10-20 gram, Radix Glehniae 10-20 gram, Radix Ophiopogonis 10-20 gram, Cortex Moutan 10-20 gram, Radix Salviae Miltiorrhizae 10-20 gram, Rhizoma Atractylodis Macrocephalae 10-20 gram, Radix Bupleuri 5-15 gram, Radix Glycyrrhizae 5-15 gram.
2. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
Rhizoma Coptidis 10 grams, Radix Trichosanthis 10 grams, the Radix Astragali 10 grams, Flos Lonicerae 10 grams, Radix Glehniae 10 grams, Radix Ophiopogonis 10 grams, Cortex Moutan 10 grams, Radix Salviae Miltiorrhizae 10 grams, the Rhizoma Atractylodis Macrocephalae 10 grams, Radix Bupleuri 5 grams, 5 grams, Radix Glycyrrhizae.
3. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
Rhizoma Coptidis 15 grams, Radix Trichosanthis 15 grams, the Radix Astragali 15 grams, Flos Lonicerae 15 grams, Radix Glehniae 15 grams, Radix Ophiopogonis 15 grams, Cortex Moutan 15 grams, Radix Salviae Miltiorrhizae 15 grams, the Rhizoma Atractylodis Macrocephalae 15 grams, Radix Bupleuri 10 grams, 10 grams, Radix Glycyrrhizae.
4. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
Rhizoma Coptidis 20 grams, Radix Trichosanthis 20 grams, the Radix Astragali 20 grams, Flos Lonicerae 20 grams, Radix Glehniae 20 grams, Radix Ophiopogonis 20 grams, Cortex Moutan 20 grams, Radix Salviae Miltiorrhizae 20 grams, the Rhizoma Atractylodis Macrocephalae 20 grams, Radix Bupleuri 15 grams, 15 grams, Radix Glycyrrhizae.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111920903A (en) * | 2020-08-07 | 2020-11-13 | 广州中医药大学第一附属医院 | Pharmaceutical composition for treating radioactive oral mucositis and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111920903A (en) * | 2020-08-07 | 2020-11-13 | 广州中医药大学第一附属医院 | Pharmaceutical composition for treating radioactive oral mucositis and preparation method thereof |
| CN111920903B (en) * | 2020-08-07 | 2021-10-01 | 广州中医药大学第一附属医院 | Pharmaceutical composition for treating radioactive oral mucositis and preparation method thereof |
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