CN105497638A - Chinese herbal preparation for treating radiation nasosinusitis and preparation method thereof - Google Patents

Chinese herbal preparation for treating radiation nasosinusitis and preparation method thereof Download PDF

Info

Publication number
CN105497638A
CN105497638A CN201610021359.6A CN201610021359A CN105497638A CN 105497638 A CN105497638 A CN 105497638A CN 201610021359 A CN201610021359 A CN 201610021359A CN 105497638 A CN105497638 A CN 105497638A
Authority
CN
China
Prior art keywords
parts
radix
rhizoma
preparation
nasal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201610021359.6A
Other languages
Chinese (zh)
Inventor
于进超
李振芝
王黎明
郑奎生
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201610021359.6A priority Critical patent/CN105497638A/en
Publication of CN105497638A publication Critical patent/CN105497638A/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718Coptis (goldthread)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48Reproductive organs
    • A61K35/50Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/58Reptiles
    • A61K35/583Snakes; Lizards, e.g. chameleons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • A61K35/646Arachnids, e.g. spiders, scorpions, ticks or mites
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/062Ascomycota
    • A61K36/066Clavicipitaceae
    • A61K36/068Cordyceps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
    • A61K36/074Ganoderma
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534Mentha (mint)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704Polygonum, e.g. knotweed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/739Sanguisorba (burnet)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/78Saururaceae (Lizard's-tail family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/898Orchidaceae (Orchid family)
    • A61K36/8988Gastrodia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/899Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/53Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Abstract

The invention relates to a Chinese herbal preparation for treating radiation nasosinusitis and a preparation method thereof. The Chinese herbal preparation solves the technical problems that the treatment effect of existing western medicine for clinical treatment of radiation nasosinusitis is not ideal, and clinical symptoms last for a long time. The Chinese herbal preparation is prepared from, by weight, 5-12 parts of rhizoma coptidis, 5-16 parts of fried cocklebur fruits, 15-25 parts of radix angelicae dahuricae, 12-26 parts of rhizoma iridis tectori, 16-28 parts of radix glycyrrhizae, 14-25 parts of paris polyphylla sm., 5-16 parts of mint, 11-18 parts of radix semiaquilegiae, 16-38 parts of herba houttuyniae, 20-32 parts of colla corii asini, 16-28 parts of cordyceps sinensis, 16-25 parts of ganoderma, 10-26 parts of dried human placenta, 12-22 parts of scorpions, 12-24 parts of radix sanguisorbae, 8-16 parts of periostracum serpentis, 15-25 parts of caulis bambusae in taeniam and 6-14 parts of rhizoma gastrodiae. The Chinese herbal preparation can be widely applied to treatment of radiation nasosinusitis.

Description

Chinese medicine preparation of a kind of radiotherapy sinusitis and preparation method thereof
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, is Chinese medicine preparation of a kind of radiotherapy sinusitis and preparation method thereof specifically.
Background technology
Radioactivity sinusitis mainly Nasopharyngeal Carcinoma Patients accepts radiotherapy, the nasal cavity that lonizing radiation cause, sinus mucosa blood vessel injury, mucous hyperemia edema, clinical manifestation is the symptoms such as watery nasal discharge, nasal obstruction, headache, asthenia, nasal endoscopy: nasal decongestion swelling, nasal cavity purulent secretion; Merge other sequela of radiotherapy toward contact: as the digestive tract reaction such as inappetence, Nausea and vomiting simultaneously; Degradation bone marrow depression sign under leukocyte and platelet.The generation of radioactivity sinusitis is relevant with radiation accumulated dose, radiation therapy technology and individual radiation-sensitive difference, and incidence rate is higher.The western medicine effect of clinical treatment radioactivity sinusitis is undesirable, and the clinical symptoms persistent period is longer, has a strong impact on quality of life.
Summary of the invention
The present invention is exactly that western medicine effect in order to solve existing clinical treatment radioactivity sinusitis is undesirable; the long-term technical problem of clinical symptoms; the symptom such as watery nasal discharge, nasal obstruction, headache, asthenia that a kind of effective radiotherapy sinusitis causes is provided; also be aided with raising body immunity simultaneously; inhibition tumor cell grows; protection marrow function, slows down Chinese medicine preparation of the radiotherapy sinusitis of symptom of digestive tract and preparation method thereof.
Technical scheme of the present invention is, a kind of Chinese medicine preparation of radiotherapy sinusitis is provided, is made up of the crude drug of following weight portion: Rhizoma Coptidis 5-12 part, Fructus Xanthii (parched) 5-16 part, Radix Angelicae Dahuricae 15-25 part, Rhizoma Belamcandae 12-26 part, Radix Glycyrrhizae 16-28 part, Rhizoma Paridis 14-25 part, Herba Menthae 5-16 part, Radix Semiaquilegiae 11-18 part, Herba Houttuyniae 16-38 part, Colla Corii Asini 20-32 part, Cordyceps 16-28 part, Ganoderma 16-25 part, Placenta Hominis 10-26 part, Scorpio 12-22 part, Radix Sanguisorbae 12-24 part, Periostracum Serpentis 8-16 part, Caulis Bambusae In Taenia 15-25 part, Rhizoma Gastrodiae 6-14 part.
Preferably, be made up of the crude drug of following weight portion: Rhizoma Coptidis 7 parts, Fructus Xanthii (parched) 9 parts, the Radix Angelicae Dahuricae 22 parts, Rhizoma Belamcandae 18 parts, 21 parts, Radix Glycyrrhizae, Rhizoma Paridis 17 parts, Herba Menthae 8 parts, Radix Semiaquilegiae 15, Herba Houttuyniae 26 parts, 24 parts, Colla Corii Asini, Cordyceps 23 parts, Ganoderma 19 parts, Placenta Hominis 14 parts, Scorpio 18, Radix Sanguisorbae 16 parts, Periostracum Serpentis 12 parts, Caulis Bambusae In Taenia 21 parts, 11 parts, Rhizoma Gastrodiae.
The present invention also provides a kind of preparation method of Chinese medicine preparation of radiotherapy sinusitis, various crude drug is clean, oven dry is placed in container, add 6-8 and doubly soak 35-55 minute to the clear water of drying rear each raw material gross weight, then decoct and extract filtrate in 2 hours; Filtering residue after extraction filtrate is added 5-7 more doubly decoct 1 hour in the clear water of filtering residue weight, extract filtrate and merge filtrate last time.
The Chinese medicine preparation of radiotherapy sinusitis of the present invention, pharmacological action and the compatible experiments of each crude drug are summarized as follows:
Rhizoma Coptidis: bitter, cold, nontoxic.Heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tells nosebleed, conjunctival congestion, and auditory meatus is suppurated.
Fructus Xanthii (parched): pungent, bitter, temperature, poisonous.Loose wind dehumidifying, clearing the nasal passage.For headche due to wind-cold, nasal sinusitis watery nasal discharge, rubella pruritus, arthralgia chiefly caused by damp pathogen contracture.
The Radix Angelicae Dahuricae: warm in nature, acrid in the mouth, gas fragrance, micro-hardship.Wind-damp dispelling, evacuation of pus of invigorating blood circulation, granulation promoting pain relieving.For headache, toothache, nasal sinusitis, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus.
Rhizoma Belamcandae: bitter, cold, poisonous, enter lung, Liver Channel.For heat-clearing and detoxifying herb, there is resolving toxin and disinhibiting the throat, removing heat-phlegm, the effect disappearing and tie of dispelling the heat.
Radix Glycyrrhizae: nature and flavor are sweet, flat, nontoxic.QI invigorating invigorating middle warmer; Relieving spasm to stop pain; Nourishing the lung to arrest cough; Eliminating fire and detoxication; Coordinating the actions of various ingredients in a prescription.Main asthenia lack of appetite; Leanness yellowish complexion; Shortness of breath and palpitation; Cough and asthma; Laryngopharynx swelling and pain.
Rhizoma Paridis: cold nature, bitter in the mouth; Slightly poisonous.Heat-clearing and toxic substances removing, reducing swelling and alleviating pain, cool liver arresting convulsion.Make in furuncle to swell carbuncle, laryngopharynx swelling and pain, convulsion with spasms.
Herba Menthae: pungent is cool.Dispelling wind and heat pathogens, the clear sharp head, sore-throat relieving rash, soothing the liver circulation of qi promoting.
Radix Semiaquilegiae: nature and flavor are sweet, bitter, cold.Enter spleen, small intestinal, urinary bladder channel.Effect heat clearing away, removing toxic substances, detumescence, eliminating stagnation, diuresis.Herba Houttuyniae: acrid in the mouth, cold, return lung meridian.Energy heat-clearing and toxic substances removing, detumescence treat skin ulcer, promoting urination to remove dampness, clearing away heat to cure dysentery, invigorating the stomach and promoting digestion.
Colla Corii Asini: nourishing YIN and moistening the lung, tonifying blood and arresting bleeding.Cure mainly: blood deficiency and yellow complexion, dizzy cardiopalmus, for controlling the principal agent of blood deficiency.
Cordyceps: invigorating the lung and the kidney, hemostasis and phlegm.For chronic cough dyspnea due to deficiency, chronic cough is spat blood, impotence and seminal emission, soreness of waist and knee joint.
Ganoderma: strengthening the body resistance, strengthens immunologic function.There is antitumor, protecting liver and detoxication, anti-aging effects.
Placenta Hominis: the kidney warming mends essence, benefiting QI and nourishing blood.Win thin for asthenia, impotence and seminal emission, chronic cough dyspnea due to deficiency, shallow complexion, lack of appetite is breathed hard.
Scorpio: nature and flavor are sweet, flat.There is removing toxic substances, anti-inflammatory analgetic, dredging collateral, expelling wind to relieve convulsion, antithrombotic, blood glucose increasing, anti-cancer and cancer-preventing.
Radix Sanguisorbae: picric acid, cold, nontoxic.Removing heat from blood, hemostasis, heat-clearing and toxic substances removing, detumescence sore.Cure mainly haematemesis, spitting of blood, hematuria, has blood in stool, eczema, pudendal pruritus.
Periostracum Serpentis: nature and flavor are salty, sweet is flat.Dispel the wind, arresting convulsion, removing toxic substances, nebula removing.For spasm of twitching, cataracta, sore throat, furuncle swells, skin pruritus.
Caulis Bambusae In Taenia: sweet in the mouth, cold nature.Removing heat-phlegm, relieving restlessness, preventing or arresting vomiting.For phlegm-heat cough, expectorant held under the arm by gallbladder fire, and palpitation with fear is not peaceful, vexed insomnia, middle wind-phlegm fan, aphasia with stiff tongue, gastropyretic vomiting.
Rhizoma Gastrodiae: feeble QI, property is put down, and sweet in the mouth is micro-pungent.Endogenous wind stopping relieving convulsion, suppressing the hyperactive liver and subsiding YANG, dispelling wind and removing obstruction in the collateral.
The invention has the beneficial effects as follows, the present invention highlights the characteristic for the treatment of by Chinese herbs, except the sinusitis caused based on radiotherapy line, simultaneously also for the toxicity that radiotherapy causes: the symptoms such as bone marrow depression, nausea and vomiting, hypoimmunity are nursed one's health.Effectively can alleviate nasal cavity, sinus mucosa hyperemia, edema, heat-clearing and toxic substances removing, anti-inflammatory analgetic, dampness removing is treating stranguria is main; Be aided with reinforcing kidney and strengthening resistance, strengthening vital QI to eliminate pathogenic factors, improve immunity of organisms, inhibition tumor cell is grown, nourishing YIN and supplementing blood, kidney tonifying, essence replenishing, and protection marrow function, increases the leukocyte of peripheral blood, hemoglobin and platelet; Also there is emesis, clearing away phlegm dissipating depression of QI effect.During treatment, oral after the meal, every day 3 times 30 days is a course for the treatment of, takes 4 courses for the treatment of altogether; According to state of an illness weight can proper extension 1-4 the course for the treatment of consolidate curative effect.The present invention is applicable to the radioactivity sinusitis that a variety of causes causes, and through clinical 69 routine patient clinical checkings, have the advantages such as drug effect is fast, side effect light, stable curative effect, effective percentage is up to 94.2%, and highly clinical expansion uses.
Further aspect of the present invention and aspect, by the description of following detailed description of the invention, clearly recorded.
Detailed description of the invention
With specific embodiment, the present invention is described in further detail below
Embodiment 1
The weight portion of each crude drug composition is: Rhizoma Coptidis 7 parts, Fructus Xanthii (parched) 9 parts, the Radix Angelicae Dahuricae 22 parts, Rhizoma Belamcandae 18 parts, 21 parts, Radix Glycyrrhizae, Rhizoma Paridis 17 parts, Herba Menthae 8 parts, Radix Semiaquilegiae 15, Herba Houttuyniae 26 parts, 24 parts, Colla Corii Asini, Cordyceps 23 parts, Ganoderma 19 parts, Placenta Hominis 14 parts, Scorpio 18, Radix Sanguisorbae 16 parts, Periostracum Serpentis 12 parts, Caulis Bambusae In Taenia 21 parts, 11 parts, Rhizoma Gastrodiae.Various crude drug is clean, oven dry is placed in container, and add 6-8 doubly to the clear water immersion 35-55 minute of drying rear each raw material gross weight, then decoction extracts filtrate in 2 hours; Filtering residue after extraction filtrate is added 5-7 more doubly decoct 1 hour in the clear water of filtering residue weight, extract filtrate and merge filtrate last time, directly can take filtrate; Also can by after filtrate drying extract, extract is made capsule or tablet is taken.Oral after the meal, 3 times/day, within 30 days, be a course for the treatment of (take medicine 20 days, have a rest 10 days), take 4 courses for the treatment of altogether.
In preparation method, preferred scheme is: the weight of the clear water added in clear water immersion process is 7 times of gross weight after each raw material stoving, decocts 6 times that the clear water weight added in filtering residue process is filtering residue weight.
Embodiment 2
The weight portion of each crude drug composition is: Rhizoma Coptidis 9 parts, Fructus Xanthii (parched) 11 parts, the Radix Angelicae Dahuricae 24 parts, Rhizoma Belamcandae 20 parts, 23 parts, Radix Glycyrrhizae, Rhizoma Paridis 19 parts, Herba Menthae 10 parts, Radix Semiaquilegiae 17, Herba Houttuyniae 28 parts, 27 parts, Colla Corii Asini, Cordyceps 26 parts, Ganoderma 22 parts, Placenta Hominis 15 parts, Scorpio 21, Radix Sanguisorbae 17 parts, Periostracum Serpentis 13 parts, Caulis Bambusae In Taenia 22 parts, 12 parts, Rhizoma Gastrodiae.Its preparation method is identical with embodiment 1.
Embodiment 3
The weight portion of each crude drug composition is: Rhizoma Coptidis 8 parts, Fructus Xanthii (parched) 8 parts, the Radix Angelicae Dahuricae 21 parts, Rhizoma Belamcandae 17 parts, 20 parts, Radix Glycyrrhizae, Rhizoma Paridis 16 parts, Herba Menthae 7 parts, Radix Semiaquilegiae 14, Herba Houttuyniae 24 parts, 21 parts, Colla Corii Asini, Cordyceps 22 parts, Ganoderma 18 parts, Placenta Hominis 13 parts, Scorpio 17, Radix Sanguisorbae 15 parts, Periostracum Serpentis 11 parts, Caulis Bambusae In Taenia 20 parts, 10 parts, Rhizoma Gastrodiae.Its preparation method is identical with embodiment 1.
Embodiment 4
The weight portion of each crude drug composition is: Rhizoma Coptidis 5 parts, Fructus Xanthii (parched) 7 parts, the Radix Angelicae Dahuricae 20 parts, Rhizoma Belamcandae 16 parts, 19 parts, Radix Glycyrrhizae, Rhizoma Paridis 15 parts, Herba Menthae 6 parts, Radix Semiaquilegiae 13, Herba Houttuyniae 24 parts, 22 parts, Colla Corii Asini, Cordyceps 20 parts, Ganoderma 17 parts, Placenta Hominis 12 parts, Scorpio 16, Radix Sanguisorbae 14 parts, Periostracum Serpentis 10 parts, Caulis Bambusae In Taenia 19 parts, 9 parts, Rhizoma Gastrodiae.Its preparation method is identical with embodiment 1.
Embodiment 5
The weight portion of each crude drug composition is: Rhizoma Coptidis 6 parts, Fructus Xanthii (parched) 10 parts, the Radix Angelicae Dahuricae 23 parts, Rhizoma Belamcandae 19 parts, 22 parts, Radix Glycyrrhizae, Rhizoma Paridis 18 parts, Herba Menthae 9 parts, Radix Semiaquilegiae 16, Herba Houttuyniae 27 parts, 26 parts, Colla Corii Asini, Cordyceps 25 parts, Ganoderma 21 parts, Placenta Hominis 16 parts, Scorpio 19, Radix Sanguisorbae 18 parts, Periostracum Serpentis 14 parts, Caulis Bambusae In Taenia 23 parts, 13 parts, Rhizoma Gastrodiae.Its preparation method is identical with embodiment 1.
The clinical experiment carried out below in conjunction with Weihai Municipal Hospital describes in detail:
1. clinical data: clinical Stochastic choice: 69 routine radioactivity sinusitis in patients.Be divided into treatment group and matched group at random with medical precedence, two groups through statistical procedures, in age, sex, equal not statistically significant.Wherein treatment group 35 example, matched group 34 example.Clinical manifestation is the symptoms such as watery nasal discharge, nasal obstruction, headache, asthenia; Nasal endoscopy: nasal decongestion swelling, nasal cavity purulent secretion; Image check: sinus mucosa is plump, part merges nasal sinuses hydrops or polyp.Other sequela of also merging radiotherapy had: as degradation bone marrow depression sign under the digestive tract reaction such as inappetence, Nausea and vomiting and leukocyte and platelet.Occur that sinusitis symptom is apart from-5 years February of radiotherapy, radiological dose: 45-70GY.
2. Therapeutic Method: treatment group, according to prescription medicament of the present invention (prepared by embodiment 1), is oral after the meal, every day three times, within 30 days, be a course for the treatment of, take medicine 20 days, have a rest 10 days, take 4 courses for the treatment of altogether, according to state of an illness weight can proper extension 1-4 the course for the treatment of consolidate curative effect.Matched group mainly adopts conservative treatment: antibiotic antiinflammatory and symptomatic treatment, to alleviate sinusitis irritation.
3. result and statistical method: whether criterion of therapeutical effect evaluates clinical symptoms alleviate or disappear, and whether laboratory inspection, nasal endoscopy and image check be normal.Cure: same or similar before its clinical symptoms, laboratory inspection, nasal endoscopy, image check and radiotherapy; Treatment is effectively: the improvement in various degree before comparatively taking medicine of its clinical symptoms, laboratory inspection, nasal endoscopy, image check; Fail to respond to any medical treatment: its clinical symptoms, laboratory inspection, nasal endoscopy, image check be unchanged or deterioration before comparatively taking medicine.Effective percentage=(curing number+significant figure)/total number of cases × 100%.
Between two groups, effective percentage uses precise probabilistic method to compare, and is shown in Table 1.
Table 1 liang group cure rate synopsis
Note: treatment group is by prescription pharmaceutical treatment of the present invention, and matched group is conventional western medicine treatment.
4. side effect and contraindication:
Side effect: through 69 routine patients clinical observation of curative effect, do not find obvious toxic-side effects.
Contraindication: allergic constitution person, anemia of pregnant woman and infant forbidding.
Case:
(1) Liu, female, 62 years old, nasopharyngeal carcinoma postoperation radiotherapy, line source is linear accelerator, exposure dose 55Gy, occurs the symptom such as watery nasal discharge, nasal obstruction, headache, asthenia after June; And have dizziness, Nausea and vomiting symptom; Laboratory checks routine blood test: hemoglobin, leukocyte reduce, and platelet is normal; Nasal endoscopy: nasal decongestion swelling, concha nasalis inferior is plump; CT is unenhanced: deviation of nasal septum, and sinus mucosa is plump.Clinical diagnosis: radioactivity sinusitis.Take Chinese medicine preparation of the present invention, after 30 days, watery nasal discharge, nasal obstruction, headache syndromes are alleviated, watery nasal discharge, nasal obstruction, headache, dizziness, Nausea and vomiting transference cure after 4 courses for the treatment of, in blood, leukocyte, platelet recovery are normally, rhinoscopy: nasal decongestion, edema disappear.Continue to take 1 the course for the treatment of consolidate curative effect, there is not untoward reaction.
(2) Lee, man, 64 years old, the postoperative row radiotherapy of nasopharyngeal carcinoma, line source is linear accelerator, exposure dose 65Gy, occurs the symptom such as watery nasal discharge, nasal obstruction, dizziness after 3 months, nasal endoscopy: nasal decongestion swelling, a small amount of purulent secretion of nasal cavity, in, concha nasalis inferior is plump; And having dizziness, Nausea and vomiting symptom, laboratory checks routine blood test: hemoglobin, leukocyte reduce, and platelet is normal; CT is unenhanced: deviation of nasal septum, and sinus mucosa is plump, and nasal cavity is shown in a small amount of hydrops.Clinical diagnosis: radioactivity sinusitis.Take Chinese medicine preparation of the present invention, after 40 days, watery nasal discharge, nasal obstruction, headache syndromes are alleviated, watery nasal discharge, nasal obstruction, dizziness, Nausea and vomiting transference cure after 4 courses for the treatment of, routine blood test: hemoglobin, leukocyte, platelet recovery are normal, nasal endoscopy: nasal membrane mild hyperaemia, edema, purulent secretion disappears.CT is unenhanced: sinus mucosa is slightly plump, and nasal cavity hydrops disappears.Continue to take 2 the course for the treatment of consolidate curative effect, there is not untoward reaction.
(3) river, man, 68 years old, nasopharyngeal carcinoma radiotherapy, line source was linear accelerator, exposure dose 70Gy, occurs watery nasal discharge, nasal obstruction, headache, asthenia symptom after January, and laboratory checks routine blood test: hemoglobin, leukocyte, platelet reduce.Nasal endoscopy: nasal membrane hyperemia, edema, erosion, measures purulent secretion in nasal cavity, in, concha nasalis inferior is plump; MRI checks: bilateral maxillary sinus, mucous membrane of ethmoid sinus are plump, and right maxillary hole intracavity is shown in nodal-like abnormal signal and a small amount of hydrops.Clinical diagnosis: radioactivity sinusitis merges antral polyp.Take Chinese medicine preparation of the present invention, watery nasal discharge, nasal obstruction remission after 2 courses for the treatment of, after 4 courses for the treatment of, headache, Nausea and vomiting symptom are obviously alleviated; Leukocyte in blood, platelet recovery are normal; Nasal endoscopy: sinus mucosa is slightly plump, nasal cavity hydrops disappears, and right maxillary hole intracavity is shown in that nodal-like abnormal signal diminishes.Continue to take 3 the course for the treatment of consolidate curative effect, there is not untoward reaction.
(4) Xu certain, female, 55 years old, nasopharyngeal carcinoma postoperative chemotherapy, line source is linear accelerator, exposure dose 60Gy, occurs the symptom such as watery nasal discharge, nasal obstruction, dizziness after 4 months; Nasal endoscopy: nasal decongestion swelling, a small amount of purulent secretion of nasal cavity, middle nasal concha is plump; And have dizziness, Nausea and vomiting symptom; Laboratory checks: leukocyte reduces, and platelet reduces; CT is unenhanced: sinus mucosa is plump.Clinical diagnosis: radioactivity sinusitis.Take Chinese medicine preparation of the present invention, after 2 courses for the treatment of, watery nasal discharge, nasal obstruction, headache syndromes are alleviated, Nausea and vomiting transference cure after 4 courses for the treatment of; Routine blood test: hemoglobin, leukocyte, platelet recovery are normal; Nasal endoscopy: nasal membrane mild hyperaemia, edema, purulent secretion disappears.CT is unenhanced: sinus mucosa is slightly plump, and nasal cavity hydrops disappears.Continue to take 2 the course for the treatment of consolidate curative effect, there is not untoward reaction.
The above, only to the preferred embodiments of the present invention, is not limited to the present invention, and for a person skilled in the art, the present invention can have various modifications and variations.Every in claim limited range of the present invention, any amendment made, equivalent replacement, improvement etc., all should within protection scope of the present invention.

Claims (3)

1. the Chinese medicine preparation of a radiotherapy sinusitis, it is characterized in that, be made up of the crude drug of following weight portion: Rhizoma Coptidis 5-12 part, Fructus Xanthii (parched) 5-16 part, Radix Angelicae Dahuricae 15-25 part, Rhizoma Belamcandae 12-26 part, Radix Glycyrrhizae 16-28 part, Rhizoma Paridis 14-25 part, Herba Menthae 5-16 part, Radix Semiaquilegiae 11-18 part, Herba Houttuyniae 16-38 part, Colla Corii Asini 20-32 part, Cordyceps 16-28 part, Ganoderma 16-25 part, Placenta Hominis 10-26 part, Scorpio 12-22 part, Radix Sanguisorbae 12-24 part, Periostracum Serpentis 8-16 part, Caulis Bambusae In Taenia 15-25 part, Rhizoma Gastrodiae 6-14 part.
2. the Chinese medicine preparation of radiotherapy sinusitis according to claim 1, it is characterized in that, be made up of the crude drug of following weight portion: Rhizoma Coptidis 7 parts, Fructus Xanthii (parched) 9 parts, the Radix Angelicae Dahuricae 22 parts, Rhizoma Belamcandae 18 parts, 21 parts, Radix Glycyrrhizae, Rhizoma Paridis 17 parts, Herba Menthae 8 parts, Radix Semiaquilegiae 15, Herba Houttuyniae 26 parts, 24 parts, Colla Corii Asini, Cordyceps 23 parts, Ganoderma 19 parts, Placenta Hominis 14 parts, Scorpio 18, Radix Sanguisorbae 16 parts, Periostracum Serpentis 12 parts, Caulis Bambusae In Taenia 21 parts, 11 parts, Rhizoma Gastrodiae.
3. the preparation method of the Chinese medicine preparation of a radiotherapy sinusitis as claimed in claim 1, it is characterized in that, various crude drug is clean, oven dry is placed in container, and add 6-8 doubly to the clear water immersion 35-55 minute of drying rear each raw material gross weight, then decoction extracts filtrate in 2 hours; Filtering residue after extraction filtrate is added 5-7 more doubly decoct 1 hour in the clear water of filtering residue weight, extract filtrate and merge filtrate last time.
CN201610021359.6A 2016-01-14 2016-01-14 Chinese herbal preparation for treating radiation nasosinusitis and preparation method thereof Pending CN105497638A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610021359.6A CN105497638A (en) 2016-01-14 2016-01-14 Chinese herbal preparation for treating radiation nasosinusitis and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610021359.6A CN105497638A (en) 2016-01-14 2016-01-14 Chinese herbal preparation for treating radiation nasosinusitis and preparation method thereof

Publications (1)

Publication Number Publication Date
CN105497638A true CN105497638A (en) 2016-04-20

Family

ID=55706193

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201610021359.6A Pending CN105497638A (en) 2016-01-14 2016-01-14 Chinese herbal preparation for treating radiation nasosinusitis and preparation method thereof

Country Status (1)

Country Link
CN (1) CN105497638A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020034087A1 (en) * 2018-08-14 2020-02-20 长庚医疗财团法人嘉义长庚纪念医院 Use of licorice extract in preparing drug for treating nasal inflammation and pharmaceutical composition including same

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101129569A (en) * 2007-08-29 2008-02-27 毕庆双 Orally taken traditional Chinese medicine medicinal decoction for treating acute sinusitis
CN104127496A (en) * 2014-07-22 2014-11-05 韩峥华 Rhinitis and nasosinusitis treatment medicine
CN104666559A (en) * 2013-11-29 2015-06-03 烟台巨先药业有限公司 Traditional Chinese medicine capsules for treating nasosinusitis

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101129569A (en) * 2007-08-29 2008-02-27 毕庆双 Orally taken traditional Chinese medicine medicinal decoction for treating acute sinusitis
CN104666559A (en) * 2013-11-29 2015-06-03 烟台巨先药业有限公司 Traditional Chinese medicine capsules for treating nasosinusitis
CN104127496A (en) * 2014-07-22 2014-11-05 韩峥华 Rhinitis and nasosinusitis treatment medicine

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
周德生等: "《中医膏方临床应用指南》", 31 October 2015, 山西科学技术出版社 *
廖利平: "《让你不生病:健康·养生·治未病》", 30 November 2008, 海天出版社 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020034087A1 (en) * 2018-08-14 2020-02-20 长庚医疗财团法人嘉义长庚纪念医院 Use of licorice extract in preparing drug for treating nasal inflammation and pharmaceutical composition including same

Similar Documents

Publication Publication Date Title
CN104225441A (en) Traditional Chinese medicine composition for treating stomach trouble and preparation method of granules and capsules of traditional Chinese medicine composition
CN103182019A (en) Traditional Chinese medicine composition for treating ROU (recurrent oral ulcer)
CN105213974A (en) One treats lymphadenomatous Chinese medicine composition and application thereof
CN102526459B (en) Traditional Chinese medicine composition for treating nasosinusitis and preparation method thereof
CN103393971B (en) Traditional Chinese medicine preparation for nursing patients suffering from rhinitis and preparation method thereof
CN105497638A (en) Chinese herbal preparation for treating radiation nasosinusitis and preparation method thereof
CN102266435A (en) Traditional Chinese medicine for treating psoriasis
CN104623381A (en) Traditional-Chinese-medicine composition for treating skin disease caused by blood heat and liver depression
CN103977276A (en) Traditional Chinese medicine capsule used for treating radiocystitis
CN104623217A (en) Traditional Chinese medicine preparation for treating asthma and preparation method thereof
CN104524531A (en) Traditional Chinese medicine composition for treating radiation proctitis and preparation method
CN104189489A (en) Medicament with effect of treating chronic eczema and preparation method thereof
CN104524124A (en) Traditional Chinese medicinal preparation for treating skull osteomyelitis and preparation method
CN105396019A (en) Pharmaceutical composition for relieving radiotherapy reaction of tumor patients
CN109512965A (en) A kind of heat-clearing TONGBI PIAN and preparation method thereof
CN103623335B (en) A kind of Chinese medicine preparation for the treatment of rhinitis
CN102772723A (en) Chinese medicinal prescription for treating phthisis
CN102389538B (en) Traditional Chinese medicine capsule preparation for treating nasopharyngitis
CN106177660A (en) A kind of Chinese medicine preparation for treating hepatocarcinoma and preparation method
CN105288158A (en) Traditional Chinese medicine for treatment of cold-dampness type chronic rhinitis
CN104116991A (en) Traditional Chinese medicine preparation for treating radiation sickness and preparation method thereof
CN103877304A (en) Drug for treating gall-stone and preparation method thereof
CN114917303A (en) Traditional Chinese medicine composition for treating rhinitis and preparation method and application thereof
CN103690636A (en) Traditional Chinese medicinal prescription for treating rhinitis
CN109550029A (en) It is a kind of to treat all cancer Chinese medicine compositions

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20160420

WD01 Invention patent application deemed withdrawn after publication