CN102657807B

CN102657807B - Chinese medicinal composition for treating radiation proctitis

Info

Publication number: CN102657807B
Application number: CN201210128227.5A
Authority: CN
Inventors: 肖玉芹; 王天松
Original assignee: Individual
Current assignee: Individual
Priority date: 2012-04-24
Filing date: 2012-04-24
Publication date: 2014-04-16
Anticipated expiration: 2032-04-24
Also published as: CN102657807A

Abstract

The invention relates to a Chinese medicinal composition for treating radiation proctitis. The composition is characterized by consisting of the following medicaments: 4 to 6 grams of phellodendron, 2 to 4 grams of atractylodes rhizome, 6 to 8 grams of dried rehmannia root, 4 to 6 grams of dendrobe, 2 to 4 grams of dwarf lilyturf root, 6 to 8 grams of pilose asiabell root, 6 to 8 grams of Chinese yam, 4 to 6 grams of tuckahoe, 4 to 6 grams of suberect spatholobus stem, 4 to 6 grams of Chinese angelica, 2 to 4 grams of pseudo-ginseng, 4 to 6 grams of agrimony, 4 to 6 grams of red peony root, 2 to 4 grams of gallnut, 4 to 6 grams of fructus amomi, 4 to 6 grams of red halloysite, 4 to 6 grams of myrobalan and 4 to 6 grams of liquorice. The composition has the advantages of clearing heat and detoxifying, strengthening spleen and eliminating dampness, removing stasis and dredging collaterals, inducing astringency and arresting discharge. Diseases are dialectically treated according to different symptoms in clinic. The Chinese medicinal composition is suitable for treating acute and chronic radiation proctitis.

Description

A kind of Chinese medicine composition of radiotherapy proctitis

Technical field

The present invention relates to a kind of Chinese medicine composition of radiotherapy proctitis.

Background technology

As everyone knows, radiotherapy is one of main method for the treatment of malignant tumor, is the radiocurable major complications of the front 1 row gland i malignant tumor of gynecologic malignant tumor, male.Pathogenesis is mainly that lonizing radiation cause that enterocyte hypertrophy is suppressed, small artery is impaired under intestinal mucosa, causes endarteritis obliterans and venous intimitis, and erosion, ulcer or hemorrhage can occur intestinal mucosa.Many after radiotherapy 1～2 week of acute stage, visible abdominal distention, the symptom such as suffer from diarrhoea, have blood in stool, many continuities in late period, can occur having blood in stool to the several years 6 months of radiotherapy, even merge rectum uterine neck fistula or recto-vaginal fistula, to patient's life, cause very large misery and inconvenience.Domestic basic employing hormone and symptomatic therapy, carry out relief of symptoms, its poor effect at present.

Summary of the invention

Technical problem to be solved by this invention is in order to overcome technical deficiency, provides relatively cheap, the Chinese medicine composition of a kind of radiotherapy proctitis that curative effect is fast, effective, have no side effect.

Its technical problem institute employing scheme that the present invention solves is: it is characterized in that being comprised of the raw material of Chinese medicine medicine of following proportioning: Cortex Phellodendri 4～6g, Rhizoma Atractylodis 2～4g, Radix Rehmanniae 6～8g, Herba Dendrobii 4～6g, Radix Ophiopogonis 2～4g, Radix Codonopsis 6～8g, Rhizoma Dioscoreae 6～8g, Poria 4～6g, Caulis Spatholobi 4～6g, Radix Angelicae Sinensis 4～6g, Radix Notoginseng 2～4g, Herba Agrimoniae 4～6g, Radix Paeoniae Rubra 4～6g, Galla Chinensis 2～4g, Fructus Amomi 4～6g, Halloysitum Rubrum 4～6g, Fructus Chebulae 4～6g, Radix Glycyrrhizae 4～6g.

The invention has the beneficial effects as follows: heat-clearing and toxic substances removing, invigorating the spleen to clear away damp pathogen, eliminating blood stasis and smoothing collaterals, astringent or styptic treatment for spontaneous sweating convergence.According to different pattern of syndrome are dialectical, treat clinically.This medicine is applicable to treat acute and chronic radiation rectitis patient.

Cortex Phellodendri bitter in the mouth in the present invention, cold in nature.Return kidney, bladder, large intestine channel.Function cures mainly: heat clearing and damp drying, eliminating fire and detoxication, except hectic fever due to YIN-deficiency clearind deficient heat.For damp-heat dysentery, sore swollen toxin, eczema pruritus ....< < Amplification on Materia Medica addendum > >: bark of a cork tree skin, walk the hands the moon of fainting, and have the merit of pathogenic fire purging nourishing YIN.Modern pharmacological research, have antibacterial, strengthen immune effect.Join Rhizoma Atractylodis and can treat damp-heat in lower-JIAO.Rhizoma Atractylodis acrid in the mouth, hardship, warm in nature.Return spleen, stomach, Liver Channel.Function cures mainly: drying damp and strengthening spleen, and expelling wind and cold.For distension and fullness in the abdomen, the edema of having loose bowels.Radix Rehmanniae sweet-bitter flavor, cool in nature.Enter the heart, liver, kidney channel.Function cures mainly: heat clearing away, promote the production of body fluid, YIN nourishing, nourish blood.< < Compendium of Materia Medica > >, we use Radix Rehmanniae YIN nourishing and the production of body fluid promoting, and Radix Codonopsis QI invigorating is moisturized, Poria strengthening the spleen tonify deficiency.Modern medicine research, Radix Rehmanniae has hemostasis, antifungal, antiinflammatory, antiallergic, antitumor action.Herba Dendrobii sweet in the mouth, cold nature, return stomach, kidney channel.Function cures mainly: reinforcing stomach reg fluid, nourishing YIN and clearing away heat.For cloudy impairment of body fluid, lose, xerostomia excessive thirst, lack of appetite is retched, deficiency-heat after being ill, poor vision.Herba Dendrobii, replenishing YIN and removing heat Radix Ophiopogonis, reinforcing stomach reg fluid.The function of Radix Ophiopogonis cures mainly: YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.For dryness of the lung dry cough, deficiency of YIN consumptive disease is coughed, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation.Radix Codonopsis Radix Codonopsis, containing various saccharides, phenols, sterol, volatile oil, scutellarein glucosid, Saponin and Alkaloid, has enhancing immunity, blood vessel dilating, blood pressure lowering, improves microcirculation, strengthens the effects such as hemopoietic function.In addition leukopenia chemotherapy radiotherapy being caused has castering action.Modern pharmacological research, has and adjusts the key medicine that gastrointestinal motility function Radix Codonopsis is invigorating the spleen and replenishing QI, can correct pathological state gastrointestinal motility dysfunction, strengthen immune effect.Rhizoma Dioscoreae is not dry oiliness.Function cures mainly: invigorating spleen and reinforcing stomach, aid digestion, for controlling, weakness of the spleen and stomach, lack of appetite body are tired, the disease of having loose bowels.Cortex Magnoliae Officinalis bitter in the mouth, pungent, warm in nature, return spleen channel, stomach warp, large intestine channel.Function with cure mainly: circulation of qi promoting removing food stagnancy, dampness are except full, lowering the adverse QI to relieve asthma.Poria slightly sweet flavor is flat, enters the heart, lung, spleen channel.There is eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, the effect of mind tranquilizing and the heart calming.The diuretic of Poria, reaches by strong activating the spleen pulmonary function.Caulis Spatholobi: bitter, sweet, temperature.Return liver, kidney channel.Be called as the plant that can bleed, function cures mainly: enrich blood, invigorate blood circulation, dredging collateral.Join Chinese angelica blood supplementing, promoting flow of qi by warming channel.< < decoction pieces is newly joined > >: Caulis Spatholobi blood stasis removing blood, tissue regeneration promoting blood, fluent passages through which vital energy circulates.Control summer filthy infection, wind arthralgia due to stagnation of blood disease.Modern medicine research, has antitumaous effect.Radix Angelicae Sinensis has oxygen lack resistant function, regulates body's immunity, has antitumaous effect, the effect of invigorating blood circulation of enriching blood, antibacterial, arteriosclerosis effect.Radix Notoginseng bitter but slightly sweet taste, warm in nature, return liver, stomach warp.Function cures mainly: hemostasis, dissipating blood stasis, detumescence, pain relieving.< < detailed outline > >: hemostasis, loose blood, analgesic therapy.Herba Agrimoniae bitter in the mouth, puckery, property is flat.Function cures mainly: astringing to arrest bleeding, dysentery relieving, parasite killing.Parasite killing.Be widely used in various hemorrhage cards.Radix Paeoniae Rubra bitter in the mouth, cold nature.Function cures mainly: clearing away heat and cooling blood, eliminating stasis to stop pain.Galla Chinensis sour in the mouth is puckery, cold in nature.Return lung, large intestine, kidney channel.Function cures mainly: astringe the lung; Hidroschesis; Astringing intestine to stop diarrhea; Controlling nocturnal emission with astringent drugs; Hemostasis; Removing toxic substances.Fructus Amomi, the pungent loose temperature of these product is logical, abnormal smells from the patient fragrance, its removing dampness is amusing, and the effect of circulation of qi promoting warming middle-JIAO is all good, and ancients say it: " for being amusing, adjust stomach key medicine." be applicable to all cards of the incoordination between the spleen and stomach such as abdominal distention due to dampness or the stagnation of QI.Halloysitum Rubrum sweet in the mouth, puckery, sour, warm in nature.Function cures mainly: astringing intestine to stop diarrhea, astringing to arrest bleeding, removing dampness sore, granulation promoting.< < detailed outline > >: " thick the intestines and stomach, dewaters wet for reinforcing the heart blood, granulation promoting meat, receives proctoptosis." for chronic diarrhea, chronic dysentery, have blood in stool.Fructus Chebulae's bitter in the mouth, acid, puckery, property is flat.Radix Glycyrrhizae, function cures mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.This disease of above Drug therapy, arranges in pairs or groups rationally, brings out the best in each other.

The present invention follows the prescriptions principle of the traditional Chinese medical science, is decocted in water for oral dose.The present invention is through clinical verification: cure rate 80.6%, and effective percentage 95.9%, inefficiency 4.1%,

The specific embodiment

Below in conjunction with implementing case, the invention will be further described:

Embodiment 1: a kind of Chinese medicine composition of radiotherapy proctitis, is characterized in that by following proportioning weighting raw materials thing: Cortex Phellodendri 4～6g, Rhizoma Atractylodis 2～4g, Radix Rehmanniae 6～8g, Herba Dendrobii 4～6g, Radix Ophiopogonis 2～4g, Radix Codonopsis 6～8g, Rhizoma Dioscoreae 6～8g, Poria 4～6g, Caulis Spatholobi 4～6g, Radix Angelicae Sinensis 4～6g, Radix Notoginseng 2～4g, Herba Agrimoniae 4～6g, Radix Paeoniae Rubra 4～6g, Galla Chinensis 2～4g, Fructus Amomi 4～6g, Halloysitum Rubrum 4～6g, Fructus Chebulae 4～6g, Radix Glycyrrhizae 4～6g.

Embodiment 2: a kind of Chinese medicine composition of radiotherapy proctitis, is characterized in that by following proportioning weighting raw materials thing: Cortex Phellodendri 6g, Rhizoma Atractylodis 2g, Radix Rehmanniae 6g, Herba Dendrobii 4g, Radix Ophiopogonis 4g, Radix Codonopsis 6g, Rhizoma Dioscoreae 6g, Poria 4g, Caulis Spatholobi 4g, Radix Angelicae Sinensis 4g, Radix Notoginseng 2g, Herba Agrimoniae 4g, Radix Paeoniae Rubra 4g, Galla Chinensis 2g, Fructus Amomi 4g, Halloysitum Rubrum 4g, Fructus Chebulae 4g, Radix Glycyrrhizae 4g.

Clinical efficacy is summed up

One, physical data: select radiotherapy radiation rectitis patient 72 examples, age 38-73 year, average 60.1 years old, in the course of disease 2 months, average 6～15 days, patient all made a definite diagnosis and implements above-mentioned treatment through hospital above county level.

Two, diagnostic criteria: have abdominal part radiotherapy history, clinical manifestation is: stool is with pus and blood, mucus and the slough that comes off, proctoscopy: visible intestinal wall is congested, swelling is russet, and ulcer, perforation, finally form narrow.

Three, method of administration: be decocted in water for oral dose, every day 1 dose, every dose 200ml, sooner or later sub-service

Four, curative effect judging standard:

Cure: clinical symptoms disappears completely;

Take a turn for the better: clinical symptoms is improved;

Do not heal: clinical symptoms is without improvement, or have and increase the weight of.

Five, therapeutic effect: clinical disease: cure 58 examples, improvement 11 examples, invalid 4 examples.Cure rate 80.6%, effective percentage 95.9%, inefficiency 4.1%,

Six, model case

1, grandson XX, female, 62 years old, in November, 2009 cervical cancer month after operation, radiation treatment 16 days, stool band pus and blood 2 days, has a small amount of mucus, companion's diarrhoea watery stool, uses Norfloxacin in treatment of male poor effect.Proctoscopy: see that intestinal wall is congested, swelling is russet.Suspend only radiotherapy.Patient occurs without hemafecia after requiring to take 8 doses, Chinese medicine of the present invention, and the Herba Agrimoniae of stopping using, continues to take 15 doses of this medicines, and clinical symptoms disappears completely, after half a year, does not follow up a case by regular visits to and does not recur.

2, king XX, man, 62 years old, in June, 2010 was because of carcinoma of prostate postoperative March, prostate radiation therapy 12 days.There are intermittent hemafecia 2 days, proctoscopy: visible intestinal wall is congested, ulcer.Through hospitalization western medicine, poor effect, patient requires to take 20 doses, Chinese medicine of the present invention, and clinical symptoms disappears completely, and proctoscopy is normal, so far not recurrence.

3, Rhizoma Zingiberis Recens XX, female, 51 years old, in November, 2010 was medical.Because of the 2nd week of cervical cancer postoperation radiotherapy, there is hemafecia in patient, stomachache, diarrhoea, malaise, under rectoscope, visible intestinal wall is congested, gives hemorrhage and antibiotic medicine treatment, Relapse rate, patient requires to take after 14 doses, Chinese medicine of the present invention, and clinical symptoms disappears completely, after half a year, does not follow up a case by regular visits to and does not recur.

Claims

1. a Chinese medicine composition for radiotherapy proctitis, is characterized in that it is the ingredients by following proportioning: Cortex Phellodendri 4～6g, Rhizoma Atractylodis 2～4g, Radix Rehmanniae 6～8g, Herba Dendrobii 4～6g, Radix Ophiopogonis 2～4g, Radix Codonopsis 6～8g, Rhizoma Dioscoreae 6～8g, Poria 4～6g, Caulis Spatholobi 4～6g, Radix Angelicae Sinensis 4～6g, Radix Notoginseng 2～4g, Herba Agrimoniae 4～6g, Radix Paeoniae Rubra 4～6g, Galla Chinensis 2～4g, Fructus Amomi 4～6g, Halloysitum Rubrum 4～6g, Fructus Chebulae 4～6g, Radix Glycyrrhizae 4～6g.