CN102302690B

CN102302690B - Traditional Chinese medicine used for treating radiation proctitis

Info

Publication number: CN102302690B
Application number: CN2011102536039A
Authority: CN
Inventors: 隋丽红
Original assignee: Individual
Current assignee: Individual
Priority date: 2011-08-31
Filing date: 2011-08-31
Publication date: 2013-03-13
Anticipated expiration: 2031-08-31
Also published as: CN102302690A

Abstract

The invention relates to a traditional Chinese medicine used for treating radiation proctitis. The traditional Chinese medicine is characterized in that: the medicine is prepared from raw medicines of: 8 to 10g of cape jasmine, 6 to 8g of lightyellow sophora root, 6 to 10g of philippine violet herb, 8 to 10g of figwort, 6 to 8g of reed rhizome, 6 to 8g of upright ladybell root, 6 to 8g of largehead atractylodes rhizome, 8 to 10g of common anemarrhena, 6 to 9g of rehmannia dride rhizome, 6 to 9g of hairyvein agrimonia herb, 8 to 10g of ligusticum, 6 to 8g of turkey-tail, 6 to 8g of ophicalcite, 6 to 8g of red halloysite, 6 to 8g of callicarpa pedunculata, 6 to 8g of potentilla discolor bunge, 6 to 8g of common andrographis herb, 6 to 8g of ligusticum chuanxiong hort, and 4 to 6g of licorice. The purposes of the traditional Chinese medicine are heat clearing, detoxicating, yin nourishing, pathogen eliminating, bleeding relieving with astringents, wound healing, and pain relieving. With the traditional Chinese medicine, tumor patients can smoothly finish radiotherapy tasks. The traditional Chinese medicine has advantages of simple formulation, convenient application, good curative effect, low price, and no toxic or side-effect. The traditional Chinese medicine is applied clinically according to differentiated symptoms, and is suitable for patients of acute and chronic radiation proctitis. When in use, there is an announcement that: when bleeding is not occurred or is stopped after treating, the application of hairyvein agrimonia herb is stopped.

Description

A kind of Chinese medicine of radiotherapy proctitis

Technical field

The present invention relates to a kind of Chinese medicine of radiotherapy proctitis.

Background technology

As everyone knows, well-known, radiotherapy is one of main method for the treatment of malignant tumor, and radiation rectitis is the common complication of abdominal part radiotherapy.The radiation rectitis traditional Chinese medical science is thought: " fire (heat), the poison, it is dry that " scope of heresy refers to that mucous membrane of rectum is subject to ionizing radiation, the acute proctitis disease that causes.The pathogenesis of radiation rectitis is mainly that lonizing radiation cause that the enterocyte hypertrophy is subjected to suppress, small artery is impaired under the intestinal mucosa, cause endarteritis obliterans and venous intimitis, difficult defecation can occur in intestinal mucosa, stool attenuates or defecation is frequent, loose stool, have blood in stool, and pendant pain waits rectum to react during stool.It is painful and inconvenient to bring to patient's life.

Summary of the invention

The present invention seeks to heat-clearing and toxic substances removing, eliminating evil, the astringing intestine to stop diarrhea hemostasis of YIN nourishing, the convergence pain relieving.Execute according to the dialectical type of clinical pattern of syndrome and to control, be applicable to the patient of acute and chronic radiation rectitis.

For achieving the above object, a kind of Chinese medicine of radiotherapy proctitis is characterized in that being comprised of the component of the material medicine proportioning of following weight: Fructus Gardeniae 8～10g, Radix Sophorae Flavescentis 6～8g, Herba Violae 6～10g, Radix Scrophulariae 8～10g, Rhizoma Phragmitis 6～8g, Radix Adenophorae (Radix Glehniae) 6～8g, the Rhizoma Atractylodis Macrocephalae 6～8g, the Rhizoma Anemarrhenae 8～10g, the Radix Rehmanniae 6～9g, Herba Agrimoniae 6～8g, Radix Angelicae Sinensis 8～10g, Coriolous Dersicolor (Fr.) Quel 6～8g, Ophicalcitum 6～8g, Halloysitum Rubrum 6～8g, Folium Callicarpae Formosanae 6～8g, Herba Potentillae Discoloris 6～8g, Herba Andrographis 6～8g, Rhizoma Chuanxiong 6～8g, Radix Glycyrrhizae 4～6g.

It is simple, easy to use that prescription of the present invention is treated preparation, good effect, cheap, have no side effect.

Its cold in nature, bitter in the mouth of Fructus Gardeniae among the present invention, function with cure mainly: the pathogenic fire purging relieving restlessness, clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, Shennong's Herbal: " cure mainly five interior pathogens, tuberculoid leprosy, red leprosy, skin infection ...." the Radix Sophorae Flavescentis heat clearing and damp drying; Wind dispelling insecticide.Cure mainly damp-heat dysentery; Discharging fresh blood stool.Modern pharmacological research: have antitumor action, effect in increasing leukocyte.Herba Violae meridian distribution of property and flavor: bitter, hot, cold, nontoxic; GUIXIN, Liver Channel.Function with cure mainly: heat-clearing and toxic substances removing, removing heat from blood detumescence.Cure mainly jaundice, dysentery.It is cold in nature for Radix Scrophulariae, sweet-bitter flavor, function with cure mainly: clearing away heat-fire, nourshing Yin and drynsessmoistening prescription, be applicable to lung-heat cough with asthma or cough due to yin deficiency, dysphoria with smothery sensation is quenched one's thirst, hectic fever due to YIN-deficiency consumptive fever, dysuria, the diseases such as constipation due to dry stool.Rhizoma Phragmitis nature and flavor: sweet cold.Return the stomach warp.Function with cure mainly: clearing away heat and promoting production of body fluid, relieving restlessness, preventing or arresting vomiting, diuresis.Radix Adenophorae (Radix Glehniae) has the merit of Yin-nourishing and body fluid promoting, clearing away heat and cooling blood, the Combined with Radiotherapy chemotherapy is used for tumor patient, especially to the patients with advanced cancer blood depletion cloudy lose, the pulmonary carcinoma of deficiency of lung-YIN, digestive tract tumor's postoperative deficiency of both QI and YIN or the dry person of the withered liquid in Tianjin that causes because of the radiotherapy impairment of YIN, have preferably curative effect.Rhizoma Atractylodis Macrocephalae bitter but sweet flavor temperature; Return the taste warp.Function with cure mainly: invigorating the spleen and benefiting QI, dampness diuretic.Rhizoma Atractylodis polysaccharide has restitution to the Proliferation of lymphocytes function, but the enhancing human body immunity function has antioxidation, anticoagulation, antitumor action.Rhizoma Anemarrhenae nature and flavor: bitter sweet cold.Return lung stomach kidney channel.Function with cure mainly: clearing away heat-fire, promote the production of body fluid and moisturize.The Herba Agrimoniae herb is the robustness astringent hemostatic, heart tonifying is arranged, rises blood pressure, blood coagulation, hemostasis, removing heat from blood, the effect such as antibiotic.Radix Angelicae Sinensis is hidden: Wen Ganxin.Return liver heart spleen channel.Function with cure mainly: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Coriolous Dersicolor (Fr.) Quel: the property slightly sweet flavor is slightly cold.Return liver spleen lung meridian.Have heat clearing away, detoxifcation, antiinflammatory, anticancer, the effect such as protect the liver.Ophicalcitum nature and flavor: sour and astringent flat; Nontoxic.Return Liver Channel.Effect: blood stasis dispelling; Hemostasis.Main haematemesis, epistaxis, have blood in stool ....Halloysitum Rubrum is sweet, puckery, temperature.Return large intestine, stomach warp.Effect: relieving diarrhea with astringents, astringing to arrest bleeding, expelling pus and promoting granulation.Shennong's Herbal: " hematochezia is red white for main dysentery, intestinal Bleach pus and blood." Folium Callicarpae Formosanae acrid in the mouth, hardship, property is flat.Return liver taste warp.Function with cure mainly: dissipating blood stasis hemostasis, reducing swelling and alleviating pain.Be used for spitting blood, spitting of blood, epistaxis is had blood in stool.The treatment gastrointestinal hemorrhage.Herba Potentillae Discoloris nature and flavor: flat sweet little hardship.Function with cure mainly: the hemostasis, dysentery relieving, the detoxifcation.Be used for spitting blood, having blood in stool.Herba Andrographis: bitter in the mouth, cold in nature.GUIXIN, lung, large intestine, urinary bladder channel.Effect: heat-clearing and toxic substances removing, removing heat from blood, detumescence, dampness.Be used for containing in the evil poison.Radix Glycyrrhizae property is flat, sweet in the mouth, returns 12 warps.Effect: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Above Chinese medicine formula is arranged in pairs or groups rationally, is brought out the best in each other, effectively radiotherapy proctitis.

The present invention follows the prescription principle of the traditional Chinese medical science, with above-mentioned Chinese medicine screening, soaks the usefulness that is decocted in water for oral dose after 30 minutes, 1 dose of every day, fried 200ml altogether, and each 100ml, early, late sub-service.

The present invention verifies through clinical practice; Cure rate 87.03%; Effective percentage 95.1%.Points for attention: bleeding patients does not occur or after the treatment stopped bleeding, stop using Herba Agrimoniae.

The specific embodiment

The invention will be further described below in conjunction with implementing case:

Implement 1: a kind of Chinese medicine of radiotherapy proctitis is characterized in that it is comprised of the component of following weight material medicine proportioning: Fructus Gardeniae 8～10g, Radix Sophorae Flavescentis 6～8g, Herba Violae 6～10g, Radix Scrophulariae 8～10g, Rhizoma Phragmitis 6～8g, Radix Adenophorae (Radix Glehniae) 6～8g, the Rhizoma Atractylodis Macrocephalae 6～8g, the Rhizoma Anemarrhenae 8～10g, the Radix Rehmanniae 6～9g, Herba Agrimoniae 6～8g, Radix Angelicae Sinensis 8～10g, Coriolous Dersicolor (Fr.) Quel 6～8g, Ophicalcitum 6～8g, Halloysitum Rubrum 6～8g, Folium Callicarpae Formosanae 6～8g, Herba Potentillae Discoloris 6～8g, Herba Andrographis 6～8g, Rhizoma Chuanxiong 6～8g, Radix Glycyrrhizae 4～6g.

Implement 2: a kind of Chinese medicine of radiotherapy proctitis is characterized in that it is comprised of the component of following weight material medicine proportioning: Fructus Gardeniae 10g, Radix Sophorae Flavescentis 8g, Herba Violae 6g, Radix Scrophulariae 8g, Rhizoma Phragmitis 8g, Radix Adenophorae (Radix Glehniae) 8g, Rhizoma Atractylodis Macrocephalae 6g, Rhizoma Anemarrhenae 8g, Radix Rehmanniae 9g, Herba Agrimoniae 6g, Radix Angelicae Sinensis 8g, Coriolous Dersicolor (Fr.) Quel 6g, Ophicalcitum 6g, Halloysitum Rubrum 8g, Folium Callicarpae Formosanae 8g, Herba Potentillae Discoloris 6g, Herba Andrographis 6g, Rhizoma Chuanxiong 8g, Radix Glycyrrhizae 6g.

Clinical efficacy is summed up:

One, physical data: select pelvic irradiation proctitis patient totally 62 examples, wherein: male 18 examples, women 44 examples; In age 35-62 year, average 44 years old, in the course of disease 3 months, average 2 days～2 months, all make a definite diagnosis through hospital above county level and implement above-mentioned treatment.

Two, diagnostic criteria: the pelvic organ tumor once was subjected to the radiotherapy history, difficult defecation occurred after causing mucous membrane of rectum damage, and stool attenuates or defecation is frequent, loose stool, have blood in stool, and pendant pain waits rectum to react during stool, late period proctostenosis, ulcer, fistulization.

Three, method of administration: be decocted in water for oral dose, 1 dose of every day, each 100ml early, late sub-service, 10 days was 1 course for the treatment of, drug withdrawal is 2 days between two courses for the treatment of.

Four, curative effect judging standard:

Cure: the clinical symptoms complete obiteration.

Take a turn for the better: clinical symptoms is improved, and without having blood in stool, has defecation irregular, loose stool or constipation.

Invalid: symptom is without improving or increasing the weight of.

Five, therapeutic effect: through clinical application for many years, treatment patient 62 examples: wherein cure 54 examples, 5 examples that take a turn for the better, 3 examples more, cure rate 87.03%; Effective percentage 95.1%.Points for attention: do not occur hemorrhage or the inactive Herba Agrimoniae of the patient through treating stopped bleeding.

Six, model case

1, high XX, man, 52 years old, in February, 2008, the carcinoma of prostate postoperation radiotherapy was 2 months, went to a doctor in 3 days because of hemafecia, and the main suit began stomachache before 5 days, stool is rare, take levofloxacin and YUANHU ZHITONG PIAN has no improvement, over nearly 3 days, stool has blood, color scarlet: have a medical check-up: lower abdomen has tenderness.Fecal occult blood testing positive (+++) namely takes 20 doses in this Chinese medicine, occur without hemafecia after taking 10 doses, the Herba Agrimoniae of then stopping using, continue to take 10 doses after, clinical symptoms complete obiteration, so far recurrence.

2, king XX, the woman, 42 years old, in JIUYUE, 2009 was medical.Tumor of pelvic cavity postoperation radiotherapy 20 days.Intermittent diarrhoea loose stool 3 days that occur, companion's lower abdomen stomachache dull pain 1 day without the naked eyes hemafecia, is looked into the fecal occult blood testing feminine gender.Colorful ultrasonic checks: prompting rectum inflammation.Through taking 10 doses of 1 courses for the treatment of of Chinese medicine of the present invention, remission.Drug withdrawal 2 days continues to take 10 doses of 1 courses for the treatment of, clinical symptoms complete obiteration, so far not recurrence.This patient is without hemafecia occurring, the Herba Agrimoniae in inactive this prescription.

3, clump XX, the woman, 43 years old, cervical cancer postoperation radiotherapy 19 days, was had blood in stool at, loose stool frequent because of defecation, pendant pain during stool, 1 week of hospitalization, bad during fashion, medical in January, 2010, have a medical check-up: shallow complexion, malaise, abdominal tenderness.Fecal occult blood experiment positive (++).The patient requires to take 1 week of drug withdrawal behind 15 doses in the Chinese medicine of the present invention, takes again 10 doses, clinical symptoms complete obiteration, so far recurrence.

Claims

1. the Chinese medicine of a radiotherapy proctitis is characterized in that it is comprised of the component of following weight material medicine proportioning: Fructus Gardeniae 8～10g, Radix Sophorae Flavescentis 6～8g, Herba Violae 6～10g, Radix Scrophulariae 8～10g, Rhizoma Phragmitis 6～8g, Radix Adenophorae (Radix Glehniae) 6～8g, the Rhizoma Atractylodis Macrocephalae 6～8g, the Rhizoma Anemarrhenae 8～10g, the Radix Rehmanniae 6～9g, Herba Agrimoniae 6～8g, Radix Angelicae Sinensis 8～10g, Coriolous Dersicolor (Fr.) Quel 6～8g, Ophicalcitum 6～8g, Halloysitum Rubrum 6～8g, Folium Callicarpae Formosanae 6～8g, Herba Potentillae Discoloris 6～8g, Herba Andrographis 6～8g, Rhizoma Chuanxiong 6～8g, Radix Glycyrrhizae 4～6g.

2. the Chinese medicine of a kind of radiotherapy proctitis according to claim 1 is characterized in that it is comprised of the component of following weight material medicine proportioning: Fructus Gardeniae 10g, Radix Sophorae Flavescentis 8g, Herba Violae 6g, Radix Scrophulariae 8g, Rhizoma Phragmitis 8g, Radix Adenophorae (Radix Glehniae) 8g, Rhizoma Atractylodis Macrocephalae 6g, Rhizoma Anemarrhenae 8g, Radix Rehmanniae 9g, Herba Agrimoniae 6g, Radix Angelicae Sinensis 8g, Coriolous Dersicolor (Fr.) Quel 6g, Ophicalcitum 6g, Halloysitum Rubrum 8g, Folium Callicarpae Formosanae 8g, Herba Potentillae Discoloris 6g, Herba Andrographis 6g, Rhizoma Chuanxiong 8g, Radix Glycyrrhizae 6g.