CN1857395A - Compound Chinese medicine composition for treating cardiac and cerebral vascular diseases - Google Patents
Compound Chinese medicine composition for treating cardiac and cerebral vascular diseases Download PDFInfo
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- CN1857395A CN1857395A CN 200610046081 CN200610046081A CN1857395A CN 1857395 A CN1857395 A CN 1857395A CN 200610046081 CN200610046081 CN 200610046081 CN 200610046081 A CN200610046081 A CN 200610046081A CN 1857395 A CN1857395 A CN 1857395A
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Abstract
The present invention relates to compound Chinese medicine composition for treating cardiac and cerebral vascular diseases. The compound Chinese medicine composition consists of total salvianolic acid in 1-99 wt%, total notoginseng stem and leaf saponin or total ginsenoside, total gynostemma pentaphylla saponin, or total puncturevine saponin in 1-99 wt%, and borneol, dalbergia wood oil or camphor in 1-99 wt%, and is compounded with pharmaceutically acceptable supplementary material to prepare pharmaceutically acceptable preparations. The medicine of the present invention has the synergistic effect of the medicine components in preventing and treating cardiac and cerebral vascular diseases.
Description
Technical field:
The present invention relates to a kind of compound preparation of the treatment cardiovascular and cerebrovascular disease based on total salvianolic acid composition.And the application of various preparations in pharmaceutical field that utilizes the inventive method to obtain, the particularly application in the medicine of preparation control cardiovascular and cerebrovascular disease, senile dementia, cerebral infarction, cerebral ischemia and other various diseases of causing by cerebral ischemia thereof etc.Make a distinction between the important and the lesser one in the full side of medicine of the present invention, compatibility is proper, and complementation is short mutually.
Background technology:
Radix Salviae Miltiorrhizae, Radix Notoginseng, Radix Ginseng, Herb Gynostemmae Pentaphylli, Fructus Tribuli, Lignum Dalbergiae Odoriferae etc. all are China's conventional Chinese medicines, and its medicine as the treatment cardiovascular and cerebrovascular disease has basis of clinical application widely and long clinical application history, and evident in efficacy.Modern pharmacology studies show that effects such as salvianolic acid has the myocardium shrinkage function of improvement, blood vessel dilating, brings high blood pressure down, improves coronary artery and cerebral artery blood flow amount, anticoagulant, raising cell hypoxia-bearing capability; Notoginseng stem and leaf total saponin, Radix Ginseng total saponins, Fructus Tribuli total saponins, Herb Gynostemmae Pentaphylli total glycosides etc. have multiple important physical activity such as blood circulation promoting and blood stasis dispelling, reduction myocardial oxygen consumption, raising brain oxygen-supplying amount, the growth of promotion cerebral nerve.
How to overcome the shortcoming of taking single medicinal material, reasonable compatibility, short complementary mutually, make it to become effective good recipe of treatment diseases of cardiovascular and cerebrovascular systems, making it to bring into play the best use of at aspect such as improve cardio-cerebrovascular function and control aging of brain, raise immunity, slow down aging, improve the quality of living is its maximum difficult point.
Summary of the invention:
The objective of the invention is defective and deficiency at above-mentioned prior art existence, provide a kind of and can overcome the shortcoming of taking single medicinal material, reasonable compatibility, short complementary mutually, make it to become effective good recipe of treatment diseases of cardiovascular and cerebrovascular systems, make it that the best use of is brought into play in the aspect improving cardio-cerebrovascular function and control aging of brain, raise immunity, slow down aging, improve the quality of living etc.
It (is the compositions of sour Radix Salviae Miltiorrhizae total phenolic acids and notoginseng stem and leaf total saponin and Borneolum Syntheticum or Lignum Dalbergiae Odoriferae oil or three kinds of Chinese medicine ingredients of Camphora that further aim of the present invention provides total salvianolic acid composition, the compositions of Radix Salviae Miltiorrhizae total phenolic acids and Radix Ginseng total saponins and Borneolum Syntheticum or Lignum Dalbergiae Odoriferae oil or three kinds of Chinese medicine ingredients of Camphora, the compositions of Radix Salviae Miltiorrhizae total phenolic acids and Radix Ginseng aerial parts total saponins and Borneolum Syntheticum or Lignum Dalbergiae Odoriferae oil or three kinds of Chinese medicine ingredients of Camphora, the compositions of Radix Salviae Miltiorrhizae total phenolic acids and Herb Gynostemmae Pentaphylli total glycosides and Borneolum Syntheticum or Lignum Dalbergiae Odoriferae oil or three kinds of Chinese medicine ingredients of Camphora, the compositions of Radix Salviae Miltiorrhizae total phenolic acids and Fructus Tribuli total saponins and Borneolum Syntheticum or Lignum Dalbergiae Odoriferae oil or three kinds of Chinese medicine ingredients of Camphora) and the application of preparation in pharmaceutical field, particularly be used to prevent and treat cardiovascular and cerebrovascular disease in preparation, senile dementia, other dysfunction that cerebral ischemia causes, the medicine of the anti-ageing disease of waiting for a long time.
The present invention is implemented by following technical proposals.
The present invention relates to a kind of is the method for the compound preparation of main preparation control cardiovascular and cerebrovascular disease, senile dementia, cerebral ischemia and other various diseases of being caused by cerebral ischemia thereof etc. by the salvianolic acid compositions, it is characterized in that this method comprises following content:
(1) (total content of compositions such as its total phenolic acid compound such as danshensu, protocatechualdehyde, salvianolic acid B is 30%～100%, and the total content of danshensu and salvianolic acid B is 20%～98% to get salvianolic acid respectively according to composition by weight calculating.) 99～1 parts of 1～99 part and 99～1 parts of notoginseng stem and leaf total saponins (content of total saponins is 20%～100% in the notoginseng stem and leaf total saponin) and Borneolum Syntheticum or Lignum Dalbergiae Odoriferae oil or Camphoras, respectively or mix the back and add suitable adjuvant such as antioxidant, chelating agent, filler, framework material etc. and make said various preparations on any pharmaceutics.As be used for can be made into forms such as corresponding tablet, granule, capsule when oral; Make powder pin, freeze-dried powder, transfusion etc. when being used to inject.
(2) (total content of compositions such as its total phenolic acid compound such as danshensu, protocatechualdehyde, salvianolic acid B is 30%～100%, and the total content of danshensu and salvianolic acid B is 20%～98% to get salvianolic acid respectively according to composition by weight calculating.) 1～99 part and Radix Ginseng total saponins (comprise Radix Ginseng aerial parts total saponins, the content of total saponins is 99～1 parts of 20%～100%99～1 part and Borneolum Syntheticum or Lignum Dalbergiae Odoriferae oil or Camphoras in the Radix Ginseng total saponins, respectively or mix the back and add suitable adjuvant such as antioxidant, chelating agent, filler, framework material etc. and make said various preparations on any pharmaceutics.As be used for can be made into forms such as corresponding tablet, granule, capsule when oral; Make powder pin, freeze-dried powder, transfusion etc. when being used to inject.
(3) (total content of compositions such as its total phenolic acid compound such as danshensu, protocatechualdehyde, salvianolic acid B is 30%～100%, and the total content of danshensu and salvianolic acid B is 20%～98% to get salvianolic acid respectively according to composition by weight calculating.) 99～1 parts of 1～99 part and 99～1 parts of Herb Gynostemmae Pentaphylli total glycosides (content of total saponins is 20%～100% in the Herb Gynostemmae Pentaphylli total glycosides) and Borneolum Syntheticum or Lignum Dalbergiae Odoriferae oil or Camphoras, respectively or mix the back and add suitable adjuvant such as antioxidant, chelating agent, filler, framework material etc. and make said various preparations on any pharmaceutics.As be used for can be made into forms such as corresponding tablet, granule, capsule when oral; Make powder pin, freeze-dried powder, transfusion etc. when being used to inject.
(4) (total content of compositions such as its total phenolic acid compound such as danshensu, protocatechualdehyde, salvianolic acid B is 30%～100%, and the total content of danshensu and salvianolic acid B is 20%～98% to get salvianolic acid respectively according to composition by weight calculating.) 1～99 part and 99～1 parts of Fructus Tribuli total saponins (content of total saponins is 20%～100% in the Fructus Tribuli total saponins) and Borneolum Syntheticum or Lignum Dalbergiae Odoriferae oil or Camphora, respectively or mix the back and add suitable adjuvant such as antioxidant, chelating agent, filler, framework material etc. and make said various preparations on any pharmaceutics.As be used for can be made into forms such as corresponding tablet, granule, capsule when oral; Make powder pin, freeze-dried powder, transfusion etc. when being used to inject.
The specific embodiment
The following examples can help those skilled in the art more fully to understand the present invention.But do not limit the present invention in any way.
Embodiment 1 salvianolic acid hawthorn stem and leaf notoginsenosides freeze-dried powder
Get salvianolic acid 2g respectively, hawthorn stem and leaf total flavones 1.5g, Borneolum Syntheticum 0.5g mix the back with an amount of water for injection dissolving, add 16g mannitol, after the dissolving, be diluted to 200ml, filter with water for injection, fill, lyophilizing adopts conventional injectable powder preparation method can obtain 100 freeze-dried powders.
Embodiment 2 salvianolic acid Radix Ginseng total saponins Lignum Dalbergiae Odoriferae oil freeze-dried powders
Get salvianolic acid 2.0g respectively, Radix Ginseng total saponins 1.0g, Lignum Dalbergiae Odoriferae oil 1.0g mixes the back and dissolves with an amount of water for injection, add 16g mannitol, after the dissolving, be diluted to 200ml, filter with water for injection, fill, lyophilizing adopts conventional injectable powder preparation method can obtain 100 freeze-dried powders.
Embodiment 3 salvianolic acid Herb Gynostemmae Pentaphylli total glycosides Camphora freeze-dried powders
Get salvianolic acid 2g respectively, Herb Gynostemmae Pentaphylli total glycosides 1.5g, Camphora 0.5g mixes the back and dissolves with an amount of water for injection, add 16g mannitol, after the dissolving, be diluted to 200ml, filter with water for injection, fill, lyophilizing adopts conventional injectable powder preparation method can obtain 100 freeze-dried powders.
Embodiment 4 salvianolic acid Fructus Tribuli total saponins Borneolum Syntheticum freeze-dried powders
Get salvianolic acid 2g respectively, Fructus Tribuli total saponins 2.5g, Borneolum Syntheticum 0.5g mixes the back and dissolves with an amount of water for injection, add 16g mannitol, after the dissolving, be diluted to 200ml, filter with water for injection, fill, lyophilizing adopts conventional injectable powder preparation method can obtain 100 freeze-dried powders.
Embodiment 5 salvianolic acid hawthorn stem and leaf notoginsenosides capsules
Get salvianolic acid 25g respectively, hawthorn stem and leaf total flavones 15g, Borneolum Syntheticum 5g, starch 150g adopts conventional capsule preparation method thereof can make 1000 capsules after mixing.
Embodiment 6 salvianolic acid Radix Ginseng total saponins Lignum Dalbergiae Odoriferae oil capsules
Get salvianolic acid 30g respectively, Radix Ginseng total saponins 10g, Lignum Dalbergiae Odoriferae oil 10g, starch 150g adopts conventional capsule preparation method thereof can make 1000 capsules after mixing.
Embodiment 7 salvianolic acid Herb Gynostemmae Pentaphylli total glycosides Camphora capsules
Get salvianolic acid 25g respectively, Herb Gynostemmae Pentaphylli total glycosides 20g, Camphora 10g, starch 150g adopts conventional capsule preparation method thereof can make 1000 capsules after mixing.
Embodiment 8 salvianolic acid Fructus Tribuli total saponins Borneolum Syntheticum capsules
Get salvianolic acid 30g respectively, Fructus Tribuli total saponins 25g, Borneolum Syntheticum 5g, starch 150g adopts conventional capsule preparation method thereof can make 1000 capsules after mixing.
The extraction of embodiment 9 Radix Salviae Miltiorrhizae total phenolic acidss
Take by weighing Radix Salviae Miltiorrhizae 1Kg, water or different concentration ethanol are extracted 1～3 time (the solvent consumption are 15Kg～30Kg), be evaporated to 0.5～1L, adds 1～4L ethanol, filters, and reclaims ethanol and can not get the salvianolic acid crude product to there being pure flavor.The salvianolic acid crude product is soluble in water, (comprise polarity, middle polarity and nonpolar macroporous adsorption resin with the separation of macroporous adsorbent resin chromatography post, the ratio of the consumption of resin and crude drug is 1: 0.2～5), water, different concentration ethanol eluting successively, collect different eluting fractions, can get the different salvianolic acid of purity.
The extraction of embodiment 10 total saponins
(1) take by weighing Radix Ginseng 1Kg, water or variable concentrations alcohol (comprising ethanol, methanol etc.) extract 1～3 time (the solvent consumption are 15Kg～30Kg), be evaporated to 0.5～1L, adds 1～4L ethanol, filters, and reclaims ethanol to there not being the alcohol flavor.Concentrate with suitable quantity of water dissolving (100～1000ml), with organic solvent degreasing (comprise petroleum ether, chloroform, ethyl acetate etc., hyposynchronization also can save), n-butanol extraction (comprising n-amyl alcohol etc.), reclaim get final product behind the n-butyl alcohol saponin slightly.
(2) take by weighing Radix Ginseng 1Kg, water or different concentration ethanol are extracted 1～3 time (the solvent consumption are 15Kg～30Kg), be evaporated to 0.5～1L, adds 1～4L ethanol, filters, and reclaims ethanol to there not being the alcohol flavor.With suitable quantity of water dissolving (100～1000ml), (comprise polarity, middle polarity and nonpolar macroporous adsorption resin through the separation of macroporous adsorbent resin chromatography post, the ratio of the consumption of resin and crude drug is 1: 0.2～5), water, different concentration ethanol eluting successively, collect the different concentration ethanol eluting fraction, get final product the different total saponins elaboration of purity.The thick total saponins that obtains in above-mentioned (1) also can be by macroporous adsorbent resin chromatography post refining (method be the same).
(3) notoginseng stem and leaf total saponin, Radix Ginseng aerial parts total saponins, Fructus Tribuli total saponins, Herb Gynostemmae Pentaphylli total glycosides also can obtain by above-mentioned same method.
Claims (9)
1, a kind of Chinese medicine compound compositions for the treatment of cardiovascular and cerebrovascular disease, it is characterized in that being grouped into (percentage by weight): Radix Salviae Miltiorrhizae total phenolic acids 1%～99% by following one-tenth, notoginseng stem and leaf total saponin or Radix Ginseng total saponins (comprising Radix Ginseng aerial parts total saponins) or Herb Gynostemmae Pentaphylli total glycosides or Fructus Tribuli total saponins 99%～1%, in above-mentioned each combination, being equipped with Borneolum Syntheticum or Lignum Dalbergiae Odoriferae oil or Camphora 99%～1% again (is the compositions of Radix Salviae Miltiorrhizae total phenolic acids and notoginseng stem and leaf total saponin and Borneolum Syntheticum or Lignum Dalbergiae Odoriferae oil or three kinds of Chinese medicine ingredients of Camphora, the compositions of Radix Salviae Miltiorrhizae total phenolic acids and Radix Ginseng total saponins and Borneolum Syntheticum or Lignum Dalbergiae Odoriferae oil or three kinds of Chinese medicine ingredients of Camphora, the compositions of Radix Salviae Miltiorrhizae total phenolic acids and Radix Ginseng aerial parts total saponins and Borneolum Syntheticum or Lignum Dalbergiae Odoriferae oil or three kinds of Chinese medicine ingredients of Camphora, the compositions of Radix Salviae Miltiorrhizae total phenolic acids and Herb Gynostemmae Pentaphylli total glycosides and Borneolum Syntheticum or Lignum Dalbergiae Odoriferae oil or three kinds of Chinese medicine ingredients of Camphora, the compositions of Radix Salviae Miltiorrhizae total phenolic acids and Fructus Tribuli total saponins and Borneolum Syntheticum or Lignum Dalbergiae Odoriferae oil or three kinds of Chinese medicine ingredients of Camphora), be equipped with proper pharmaceutical excipients and make the pharmaceutically various preparations of acceptable.
2, according to right 1 described preparation, it is characterized in that Radix Salviae Miltiorrhizae total phenolic acids in the described composition is the water-soluble phenolic acid compounds in the Radix Salviae Miltiorrhizae, the content of total composition such as its total phenolic acid compound such as danshensu, protocatechualdehyde, salvianolic acid B is 30%～100%, and wherein the content sum of danshensu and salvianolic acid B is 20%～98%.
3, according to right 1 described preparation, the content that it is characterized in that total saponins in the notoginseng stem and leaf total saponin in the described composition is 20%～100%.
4,, it is characterized in that the content of total saponins in the Radix Ginseng total saponins (comprising Radix Ginseng aerial parts total saponins) in the described composition is 20%～100% according to right 1 described preparation.
5, according to right 1 described preparation, the content that it is characterized in that total saponins in the Herb Gynostemmae Pentaphylli total glycosides in the described composition is 20%～100%.
6, according to right 1 described preparation, the content that it is characterized in that total saponins in the Fructus Tribuli total saponins in the described composition is 20%～100%.
7, according to right 1 described preparation of compositions method, it is characterized in that; It is the characteristics according to various compositionss, and the modern preparation technique that allows on the employing pharmaceutics is realized.
8, all kinds of preparations of making according to right 1 described compositions, it is characterized in that: it comprises injection type, peroral dosage form, percutaneous dosing dosage form, mucosa absorption dosage form.
9, all kinds of preparations of making according to right 1 described compositions is characterized in that being mainly used in other dysfunction, the anti-ageing disease of waiting for a long time that control cardiovascular and cerebrovascular disease, senile dementia, cerebral infarction, cerebral ischemia cause.
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| CN 200610046081 CN1857395A (en) | 2006-03-17 | 2006-03-17 | Compound Chinese medicine composition for treating cardiac and cerebral vascular diseases |
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| CN 200610046081 CN1857395A (en) | 2006-03-17 | 2006-03-17 | Compound Chinese medicine composition for treating cardiac and cerebral vascular diseases |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102669345A (en) * | 2012-05-20 | 2012-09-19 | 北京绿源求证科技发展有限责任公司 | Brain nourishing nutrition food of brain nourishing tea granule |
| CN103479712A (en) * | 2013-08-06 | 2014-01-01 | 上海市闸北区中医医院 | Traditional Chinese medicine composition for treating coronary heart disease angina and application thereof |
| CN112807342A (en) * | 2021-01-11 | 2021-05-18 | 大连市检验检测认证技术服务中心 | Dalbergia wood composition and application thereof |
-
2006
- 2006-03-17 CN CN 200610046081 patent/CN1857395A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102669345A (en) * | 2012-05-20 | 2012-09-19 | 北京绿源求证科技发展有限责任公司 | Brain nourishing nutrition food of brain nourishing tea granule |
| CN103479712A (en) * | 2013-08-06 | 2014-01-01 | 上海市闸北区中医医院 | Traditional Chinese medicine composition for treating coronary heart disease angina and application thereof |
| CN103479712B (en) * | 2013-08-06 | 2015-04-22 | 上海市闸北区中医医院 | Traditional Chinese medicine composition for treating coronary heart disease angina and application thereof |
| CN112807342A (en) * | 2021-01-11 | 2021-05-18 | 大连市检验检测认证技术服务中心 | Dalbergia wood composition and application thereof |
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