CN1857388A - Preparation and application of notoginseng stem and leaf total saponin composition - Google Patents
Preparation and application of notoginseng stem and leaf total saponin composition Download PDFInfo
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- CN1857388A CN1857388A CN 200610046084 CN200610046084A CN1857388A CN 1857388 A CN1857388 A CN 1857388A CN 200610046084 CN200610046084 CN 200610046084 CN 200610046084 A CN200610046084 A CN 200610046084A CN 1857388 A CN1857388 A CN 1857388A
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Abstract
The present invention relates to compound preparation with total notoginseng stem and leaf saponin composition as main component for treating cardiac and cerebral vascular diseases. The total notoginseng stem and leaf saponin composition contains total notoginseng stem and leaf saponin in 1-99 wt% and pueraria flavonid, total erigeron braviscapus flavone, total astragalus saponin or total salvianolic acid in 1-99 wt%, and is compounded with pharmaceutically acceptable supplementary material to prepare pharmaceutically acceptable preparations. The medicine of the present invention is used in preventing and treating cardiac and cerebral vascular diseases, senile dementia, and other diseases.
Description
Technical field:
The present invention relates to a kind of compound preparation of the treatment cardiovascular and cerebrovascular disease based on notoginseng stem and leaf total saponin composition.And the application of various preparations in pharmaceutical field that utilizes the inventive method to obtain, the particularly application in the medicine of preparation control cardiovascular and cerebrovascular disease, senile dementia, cerebral infarction, cerebral ischemia and other various diseases of causing by cerebral ischemia thereof etc.Make a distinction between the important and the lesser one in the full side of medicine of the present invention, compatibility is proper, and complementation is short mutually.
Background technology:
Radix Notoginseng, Radix Puerariae, Herba Erigerontis, the Radix Astragali, Radix Salviae Miltiorrhizae etc. all are China's conventional Chinese medicines, and its medicine as the treatment cardiovascular and cerebrovascular disease has basis of clinical application widely and long clinical application history, and evident in efficacy.Modern pharmacology studies show that notoginseng stem and leaf total saponin has multiple important physical activity such as blood circulation promoting and blood stasis dispelling, reduction myocardial oxygen consumption, raising brain oxygen-supplying amount, the growth of promotion cerebral nerve; Radix Puerariae total flavones (its main component is a puerarin) has promoting blood circulation and stopping pain, expansion is normal and the coronary vasodilator of spasm, lax vascular smooth muscle, improve ischemic region the cardiac muscle power supply, reduce the myocardium lactic acid that causes because of ischemia generation, reduce oxygen consumption, improve effect such as myocardial metabolism; Herba Erigerontis has the myocardial oxygen delivery of improvement and multiple important physical effects such as hemorheology, removing interior free yl, and the breviscapine that wherein contains is its main effective ingredient; Radix Astragali total saponins has the myocardium shrinkage function of improvement, dwindles myocardial infarction area, alleviates myocardial damage, improves myocardial ischemia, protects effects such as cardiovascular and cerebrovascular vessel, microcirculation improvement, antiviral property myocarditis; Effects such as salvianolic acid has the myocardium shrinkage function of improvement, blood vessel dilating, bring high blood pressure down, improve coronary artery and cerebral artery blood flow amount, anticoagulant, raising cell hypoxia-bearing capability.
How to overcome the shortcoming of taking single medicinal material, reasonable compatibility, short complementary mutually, make it to become effective good recipe of the treatment diseases of cardiovascular and cerebrovascular systems and the disease of suffering from a deficiency of the kidney, making it improving aspect performance the best use ofs such as cardio-cerebrovascular function and control aging of brain, raise immunity, slow down aging is its maximum difficult point.
Summary of the invention:
The objective of the invention is defective and deficiency at above-mentioned prior art existence, provide a kind of and can overcome the shortcoming of taking single medicinal material, reasonable compatibility, short complementary mutually, make it to become effective good recipe of treatment diseases of cardiovascular and cerebrovascular systems, make it improving aspect performance the best use ofs such as cardio-cerebrovascular function and control aging of brain, raise immunity, slow down aging.
Further aim of the present invention provides the notoginseng stem and leaf total saponin composition (compositions of notoginseng stem and leaf total saponin and Radix Puerariae total flavones, the compositions of notoginseng stem and leaf total saponin and Herba Erigerontis total flavones, the compositions of notoginseng stem and leaf total saponin and Radix Astragali total saponins, the compositions of notoginseng stem and leaf total saponin and Radix Salviae Miltiorrhizae total phenolic acids) and the application of preparation in pharmaceutical field, particularly be used to prevent and treat the medicine of the diseases such as other dysfunction that cardiovascular and cerebrovascular disease, senile dementia, cerebral ischemia cause in preparation.
The present invention is implemented by following technical proposals.
The present invention relates to a kind of is the method for the compound preparation of main preparation control cardiovascular and cerebrovascular disease, senile dementia, cerebral ischemia and other various diseases of being caused by cerebral ischemia thereof etc. by notoginseng stem and leaf total saponin composition, it is characterized in that this method comprises following content:
(1) calculates according to composition by weight and get 1～99 part of notoginseng stem and leaf total saponin (content of total saponins should be 40%～100% in the notoginseng stem and leaf total saponin) and Radix Puerariae total flavones respectively (content of total flavone is 20%～100% in the Radix Puerariae total flavones, comprise that also content reaches the puerarin more than 80%) 99～1 parts, respectively or mix the back and add suitable adjuvant such as antioxidant, chelating agent, filler, framework material etc. and make said various preparations on any pharmaceutics.As be used for can be made into forms such as corresponding tablet, granule, capsule when oral; Make powder pin, freeze-dried powder, transfusion etc. when being used to inject.
(2) calculate according to composition by weight and get 99～1 parts of 1～99 part of notoginseng stem and leaf total saponin (content of total saponins should be 40%～100% in the notoginseng stem and leaf total saponin) and Herba Erigerontis total flavones (content of flavone is 20%～100% in the breviscapine) respectively, respectively or mix the suitable adjuvant of back adding such as antioxidant, chelating agent, filler, framework material etc. and make said various preparations on any pharmaceutics.As be used for can be made into forms such as corresponding tablet, granule, capsule when oral; Make powder pin, freeze-dried powder, transfusion etc. when being used to inject.
(3) calculate according to composition by weight and get 99～1 parts of 1～99 part of notoginseng stem and leaf total saponin (content of total saponins should be 40%～100% in the notoginseng stem and leaf total saponin) and Radix Astragali total saponinss (content of total saponins is 20%～100% in the Radix Astragali total saponins) respectively, respectively or mix the suitable adjuvant of back adding such as antioxidant, chelating agent, filler, framework material etc. and make said various preparations on any pharmaceutics.As be used for can be made into forms such as corresponding tablet, granule, capsule when oral; Make powder pin, freeze-dried powder, transfusion etc. when being used to inject.
(4) calculate according to composition by weight and get 1～99 part of notoginseng stem and leaf total saponin (content of total saponins should be 40%～100% in the notoginseng stem and leaf total saponin) and Radix Salviae Miltiorrhizae total phenolic acids respectively (Radix Salviae Miltiorrhizae total phenolic acids is the phenolic acid compound that contains in the salviamiltiorrhizabung, the phenolic acid compound wherein such as the content of water-soluble phenolic acid compounds such as danshensu, salvianolic acid B are 30%～100%) 99～1 parts, respectively or mix the back and add suitable adjuvant such as antioxidant, chelating agent, filler, framework material etc. and make said various preparations on any pharmaceutics.As be used for can be made into forms such as corresponding tablet, granule, capsule when oral; Make powder pin, freeze-dried powder, transfusion etc. when being used to inject.
The specific embodiment
The following examples can help those skilled in the art more fully to understand the present invention.But do not limit the present invention in any way.
Embodiment 1 notoginseng stem and leaf total saponin Radix Puerariae freeze-dried powder
Get notoginseng stem and leaf total saponin 3g respectively, Radix Puerariae total flavones 1.4g mixes the back with an amount of water for injection dissolving, adds 16g mannitol, after the dissolving, be diluted to 200ml, filter with water for injection, fill, lyophilizing adopts conventional injectable powder preparation method can obtain 100 freeze-dried powders.
Embodiment 2 notoginseng stem and leaf total saponin breviscapine frozen dry powders
Get notoginseng stem and leaf total saponin 3g respectively, breviscapine 1.0g mixes the back with an amount of water for injection dissolving, adds 16g mannitol, after the dissolving, be diluted to 200ml, filter with water for injection, fill, lyophilizing adopts conventional injectable powder preparation method can obtain 100 freeze-dried powders.
Embodiment 3 notoginseng stem and leaf total saponin Radix Astragali freeze-dried powders
Get notoginseng stem and leaf total saponin 2g respectively, Radix Astragali total saponins 3g mixes the back with an amount of water for injection dissolving, adds 16g mannitol, after the dissolving, be diluted to 200ml, filter with water for injection, fill, lyophilizing adopts conventional injectable powder preparation method can obtain 100 freeze-dried powders.
Embodiment 4 notoginseng stem and leaf total saponin Radix Salviae Miltiorrhizae freeze-dried powders
Get notoginseng stem and leaf total saponin 3g respectively, Radix Salviae Miltiorrhizae total phenolic acids 2.0g mixes the back with an amount of water for injection dissolving, adds 16g mannitol, after the dissolving, be diluted to 200ml, filter with water for injection, fill, lyophilizing adopts conventional injectable powder preparation method can obtain 100 freeze-dried powders.
Embodiment 5 notoginseng stem and leaf total saponin radix puerariae capsules
Get notoginseng stem and leaf total saponin 30g respectively, Radix Puerariae total flavones 20g mixes the back with an amount of water for injection dissolving, adds 16g mannitol, after the dissolving, be diluted to 200ml, filter with water for injection, fill, lyophilizing adopts conventional injectable powder preparation method can obtain 100 freeze-dried powders.
Embodiment 6 notoginseng stem and leaf total saponin breviscapine capsules
Get notoginseng stem and leaf total saponin 40g respectively, breviscapine 20g, starch 150g adopts conventional capsule preparation method thereof can make 1000 capsules after mixing.
Embodiment 7 notoginseng stem and leaf total saponin Radix Astragali capsules
Get notoginseng stem and leaf total saponin 30g respectively, Radix Astragali total saponins 30g, starch 150g adopts conventional capsule preparation method thereof can make 1000 capsules after mixing.
Embodiment 8 notoginseng stem and leaf total saponin capsule of red sage root
Get notoginseng stem and leaf total saponin 30g respectively, Radix Salviae Miltiorrhizae total phenolic acids 20g, starch 150g adopts conventional capsule preparation method thereof can make 1000 capsules after mixing.
The extraction of embodiment 9 Herba Erigerontis total flavones, Radix Puerariae total flavones, Radix Astragali total flavones
(1) take by weighing Herba Erigerontis or Radix Puerariae or Radix Astragali 1Kg, water or variable concentrations alcohol (comprising ethanol, methanol etc.) extract 1～3 time (the solvent consumption are 15Kg～30Kg), be evaporated to 0.5～1L, adds 1～4L ethanol, filters, and reclaims ethanol to there not being the alcohol flavor.Concentrate with suitable quantity of water dissolving (100～1000ml), with organic solvent degreasing (comprise petroleum ether, chloroform, etc., hyposynchronization also can save), extractions such as ethyl acetate or n-butyl alcohol or n-amyl alcohol, get final product behind the recovery organic solvent the total flavones crude product.
(2) take by weighing Herba Erigerontis or Radix Puerariae or Radix Astragali 1Kg, add 6～10 times of water gagings, regulate pH to 8～9, decocted 0.5～3 hour, filter, extract so repeatedly 1～3 time with lime cream.Merge extractive liquid, is chilled to below 70 ℃, regulates pH to 3～5 with acid (comprising mineral acid and organic acid such as acetic acid, trichloroacetic acid such as hydrochloric acid, sulphuric acid), and is static, filter get final product the total flavones crude product.
(3) take by weighing Herba Erigerontis or Radix Puerariae or Radix Astragali 1Kg, water or different concentration ethanol are extracted 1～3 time (the solvent consumption are 15Kg～30Kg), be evaporated to 0.5～1L, adds 1～4L ethanol, filters, and reclaims ethanol to there not being the alcohol flavor.With suitable quantity of water dissolving (100～1000ml), (comprise polarity, middle polarity and nonpolar macroporous adsorption resin through the separation of macroporous adsorbent resin chromatography post, the ratio of the consumption of resin and crude drug is 1: 0.2～5), water, different concentration ethanol or methanol-eluted fractions successively, collect different concentration ethanol or methanol-eluted fractions fraction, reclaim get final product behind the solvent the different total flavones elaboration of purity.The total flavones crude product that obtains in above-mentioned (1 and 2) also can be by macroporous adsorbent resin chromatography post refining (method be the same).
(4) take by weighing Herba Erigerontis or Radix Puerariae or Radix Astragali 1Kg, water or different concentration ethanol are extracted 1～3 time (the solvent consumption are 15Kg～30Kg), be evaporated to 0.5～1L, adds 1～4L ethanol, filters, and reclaims ethanol to there not being the alcohol flavor.With suitable quantity of water dissolving (100～1000ml), separate through the polyamide chromatographic column, water, different concentration ethanol or methanol-eluted fractions are collected different concentration ethanol or methanol-eluted fractions fraction successively, reclaim get final product behind the solvent the different total flavones elaboration of purity.The total flavones crude product that obtains in above-mentioned (1 and 2) also can be by polyamide chromatographic column refining (method be the same).
The extraction of embodiment 10 stem and leaf of Radix Notoginseng total glycosides
(1) take by weighing stem and leaf of Radix Notoginseng 1Kg, water or variable concentrations alcohol (comprising ethanol, methanol etc.) extract 1～3 time (the solvent consumption are 15Kg～30Kg), be evaporated to 0.5～1L, adds 1～4L ethanol, filters, and reclaims ethanol to there not being the alcohol flavor.Concentrate with suitable quantity of water dissolving (100～1000ml), with organic solvent degreasing (comprise petroleum ether, chloroform, ethyl acetate etc., hyposynchronization also can save), n-butanol extraction (comprising n-amyl alcohol etc.), reclaim get final product behind the n-butyl alcohol saponin slightly.
(2) take by weighing stem and leaf of Radix Notoginseng 1Kg, water or different concentration ethanol are extracted 1～3 time (the solvent consumption are 15Kg～30Kg), be evaporated to 0.5～1L, adds 1～4L ethanol, filters, and reclaims ethanol to there not being the alcohol flavor.With suitable quantity of water dissolving (100～1000ml), (comprise polarity, middle polarity and nonpolar macroporous adsorption resin through the separation of macroporous adsorbent resin chromatography post, the ratio of the consumption of resin and crude drug is 1: 0.2～5), water, different concentration ethanol eluting successively, collect the different concentration ethanol eluting fraction, get final product the different total saponins elaboration of purity.The thick total saponins that obtains in above-mentioned (1) also can be by macroporous adsorbent resin chromatography post refining (method be the same).
The extraction of embodiment 11 Radix Salviae Miltiorrhizae total phenolic acidss
Take by weighing Radix Salviae Miltiorrhizae 1Kg, water or different concentration ethanol are extracted 1～3 time (the solvent consumption are 15Kg～30Kg), be evaporated to 0.5～1L, adds 1～4L ethanol, filters, and reclaims ethanol and can not get the salvianolic acid crude product to there being pure flavor.The salvianolic acid crude product is soluble in water, (comprise polarity, middle polarity and nonpolar macroporous adsorption resin with the separation of macroporous adsorbent resin chromatography post, the ratio of the consumption of resin and crude drug is 1: 0.2～5), water, different concentration ethanol eluting successively, collect different eluting fractions, can get the different salvianolic acid of purity.
Claims (9)
1, a kind of notoginseng stem and leaf total saponin composition, it is characterized in that being grouped into (percentage by weight): notoginseng stem and leaf total saponin 1%～99%, Radix Puerariae total flavones 99%～1% or Herba Erigerontis total flavones 99%～1% or Radix Astragali total saponins 99%～1% or Radix Salviae Miltiorrhizae total phenolic acids 99%～1% by following one-tenth.More particularly, be meant in notoginseng stem and leaf total saponin and the said medicine combination of any one or two or more medicines, be equipped with suitable pharmaceutic adjuvant and make the pharmaceutically various preparations of acceptable.
2, according to right 1 described preparation, it is characterized in that: in the described composition in the notoginseng stem and leaf total saponin content of total saponins should be 40%～100%.
3, according to right 1 described preparation, it is characterized in that: content of total flavone is 20%～100% in the Radix Puerariae total flavones in the described composition, comprises that also content reaches the puerarin more than 90%.
4, according to right 1 described preparation, it is characterized in that: content of total flavone is 20%～100% in the Herba Erigerontis total flavones in the described composition, comprises that also content reaches the breviscapine more than 90%.
5, according to right 1 described preparation, it is characterized in that: the content of total saponins is 20%～100% in the Radix Astragali total saponins in the described composition.
6, according to right 1 described preparation, it is characterized in that: the Radix Salviae Miltiorrhizae total phenolic acids in the described composition is the phenolic acid compound that contains in the salviamiltiorrhizabung, and the phenolic acid compound wherein such as the content of water-soluble phenolic acid compounds such as danshensu, salvianolic acid B are 30%～100%.
7, according to right 1 described preparation of compositions method, it is characterized in that; It is the characteristics according to various compositionss, and the modern preparation technique that allows on the employing pharmaceutics is realized.
8, all kinds of preparations of making according to right 1 described compositions, it is characterized in that: it comprises injection type, peroral dosage form, percutaneous dosing dosage form, mucosa absorption dosage form.
9, all kinds of preparations of making according to right 1 described compositions is characterized in that: be mainly used in the diseases such as other dysfunction that control cardiovascular and cerebrovascular disease, senile dementia, cerebral infarction, cerebral ischemia cause.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101185669B (en) * | 2006-11-23 | 2011-01-12 | 河北智同医药控股集团有限公司 | Medicine composition for treating cardiovascular and cerebrovascular diseases |
| CN101199565B (en) * | 2006-12-12 | 2012-05-30 | 上海中医药大学附属龙华医院 | Pseudo-ginseng bud active site and preparation method thereof |
| CN104147127A (en) * | 2014-07-25 | 2014-11-19 | 黑龙江中医药大学 | Traditional Chinese medicinal composition for treating malignant tumors, as well as preparation method and application thereof |
| CN104305192A (en) * | 2014-10-23 | 2015-01-28 | 贡岳松 | Functional food for improving memory of Alzheimer's Disease patient and preparation method of functional food |
| CN109420041A (en) * | 2017-08-22 | 2019-03-05 | 黄建华 | One kind is for treating cardiopathic Chinese medicine composition and its preparation method and application |
| CN110339232A (en) * | 2018-04-04 | 2019-10-18 | 天士力医药集团股份有限公司 | A kind of Chinese medicine composition prevented and/or treat ischemical reperfusion injury |
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2006
- 2006-03-17 CN CN 200610046084 patent/CN1857388A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101185669B (en) * | 2006-11-23 | 2011-01-12 | 河北智同医药控股集团有限公司 | Medicine composition for treating cardiovascular and cerebrovascular diseases |
| CN101199565B (en) * | 2006-12-12 | 2012-05-30 | 上海中医药大学附属龙华医院 | Pseudo-ginseng bud active site and preparation method thereof |
| CN104147127A (en) * | 2014-07-25 | 2014-11-19 | 黑龙江中医药大学 | Traditional Chinese medicinal composition for treating malignant tumors, as well as preparation method and application thereof |
| CN104147127B (en) * | 2014-07-25 | 2019-09-27 | 黑龙江中医药大学 | A kind of Chinese medicine composition and its preparation method and application for treating malignant tumour |
| CN104305192A (en) * | 2014-10-23 | 2015-01-28 | 贡岳松 | Functional food for improving memory of Alzheimer's Disease patient and preparation method of functional food |
| CN104305192B (en) * | 2014-10-23 | 2016-05-04 | 贡岳松 | Improve functional food of patients of senile dementia memory and preparation method thereof |
| CN109420041A (en) * | 2017-08-22 | 2019-03-05 | 黄建华 | One kind is for treating cardiopathic Chinese medicine composition and its preparation method and application |
| CN110339232A (en) * | 2018-04-04 | 2019-10-18 | 天士力医药集团股份有限公司 | A kind of Chinese medicine composition prevented and/or treat ischemical reperfusion injury |
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