CN102526488A - Chinese medicine composition with pharynx-cleaning effect - Google Patents
Chinese medicine composition with pharynx-cleaning effect Download PDFInfo
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Abstract
The invention discloses a Chinese medicine composition with a pharynx-cleaning effect, which is prepared by raw materials including honeysuckle, platycodon grandiflorum, burdock, radix scrophulariae, Chinese olive, rehmannia, radix ophiopogonis, mentha haplocalyx, rhizoma polygonati and the like. The Chinese medicine composition with the pharynx-cleaning effect has the advantages of being good in curative effect, low in side effect and fast in effect.
Description
Technical field
The invention belongs to field of medicaments, be specifically related to a kind of Chinese medicine composition with function of moistening and cleaning throat, preparation and preparation method thereof.
Background technology
The sickness rate of pharyngolaryngitis is high always in China, and in rising trend.In the city, the sickness rate of pharyngitis accounts for the 10%-20% of all disease of pharynx, and the rural area is lower, accounts for about 5.5%.Be mainly in the adult.In the patient who goes to a doctor every day, pharyngolaryngitis has accounted for very big ratio.If pharyngolaryngitis pays no heed to or malpractice very easily forms chronic pharyngolaryngitis, even cancerates.
Pharyngolaryngitis is the inflammation of pharyngeal mucosa, submucous tissue, often is the part of upper respiratory tract infection.Different according to the length of the course of disease and pathological change character are divided into two big types of acute pharyngitis, chronic pharyngitiss.Chronic pharyngitis is a kind of commonly encountered diseases, frequently-occurring disease clinically, and is relatively more obstinate in the Drug therapy of routine, and outbreak repeatedly.
Traditional medicine thinks that the chronic pharyngitis etiology and pathogenesis is often deficient for internal organs, consumption impairment of YIN gas, and hyperactivity of deficient fire causes in throat; Or because of acute pharyngitis due to wind-heat shows effect repeatedly, surplus evil the delay, or dust, foul smell stimulate; The hobby tobacco and wine are pungent, and impairment caused by overstrain excessively waits and causes that deficiency of lung-YIN is deficiency of body fluid then; Throat loses in moistening foster, and furthermore asthenic fire is followed through last inflammation; Deficiency of the kidney yin, network is in lung on the passages through which vital energy circulates of kidney, and deficiency of the kidney yin then causes the also deficiency of YIN of lung, and hyperactivity of deficient fire causes sore throat then.In addition, steam on the asthenic fire, expectorant is burnt in Tianjin, venation numbness resistance in addition, and disorder of QI movement causes stagnation of QI expectorant and coagulates phlegm-fire pent-up.Doctor trained in Western medicine it is generally acknowledged that the chronic pharyngitis cause of disease is: 1. acute pharyngitis shows effect repeatedly; 2. the upper respiratory tract chronic inflammatory disease stimulates, like sinusitis, and chronic tonsillitis etc.; 3. tobacco and wine are excessive, and dust, harmful gas etc. stimulate and happiness food irritable food; 4. occupational factor (teacher and chanteur) and physical factors; 5. systemic factor: anemia, dyspepsia, heart disease, chronic tracheitis, endocrine regulation etc.Current research to chronic pharyngitis shows: viral infection plays an important role in the morbidity of infective pharyngitis, it is reported that the recall rate of the pharyngeal virus of pharyngitis patient is 27%, is mainly Epstein-Barr virus and adenovirus.Bacterial infection still is one of important paathogenic factor of pharyngitis.Pathogenic bacterium are mainly Hemolytic streptococcus, secondly bite blood bacillus, mycoplasma pneumoniae etc. for staphylococcus aureus, influenza.In addition, the symptom of allergic inflammations such as the pharyngeal gargalesthesia paroxysmal of chronic pharyngitis patient's tool dry cough and allergen detect has positive rate up to 50%～60% report, all points out the allergy factor in the chronic pharyngitis morbidity, to have important function.
Western medicine is to select antiviral agents for use mostly at present; Like Moroxydine, diamantane (obsolete), interferon etc. or antibiotic and the temporary transient disease controlling of sulfa drugs; But it is harmful unhelpful to take too many antibiotic, because abuse of antibiotics possibly cause the imbalance of bottleneck throat normal flora.And can cause the resistance reinforcement, immune function of human body goes down, and causes the state of an illness difficult repeatedly.Chinese medicine all has better curative effect to virus and bacterial infection, and it is the basis with the Chinese medical discrimination theory, and increasing liquid, nourishing the lung and kidney, removing heat-phlegm, the sore-throat relieving that wets one's whistle with YIN nourishing is the rule of treatment, can bring into play better therapeutic effect.
Chinese patent CN95110560.4 discloses a kind of Chinese medicine composition and processing method thereof of treating chronic pharyngitis.By Radix Asparagi 10-25, Radix Ophiopogonis 5-15, Radix Glehniae 5-15, Rhizoma Polygonati Odorati 5-15, Flos Lonicerae 5-15, Radix Glycyrrhizae 1-10, Flos Chrysanthemi Indici 5-15, Pericarpium Citri Reticulatae 1-10, Semen Sterculiae Lychnophorae 10-25.Be applied to clinical, treatment YIN-deficiency type, phlegm-heat type, qi-asthenia type chnonic pharyngtis, total effective rate reaches 98%.
Chinese patent CN200610086678.1 provides a kind of treatment acute/chronic pharyngitis, tonsillitic Chinese medicine composition and preparation method thereof.Said composition mainly by: Radix Scutellariae, FRUCTUS TERMINALIAE IMMATURUS, Radix Platycodonis, Caulis Bambusae In Taenia, Semen Sterculiae Lychnophorae, dried tangerine peel, Fructus Aurantii, Folium Mori, Rhizoma Cyperi (vinegar system), Fructus Perillae, Caulis Perillae, Lignum Aquilariae Resinatum, Mentholum etc. are processed.This compositions directly or indirectly adds pharmaceutically acceptable excipient through common process and processes clinical acceptable forms; Like capsule, pill, tablet, buccal tablet, granule, oral liquid or injection etc.; This compositions has relieving sore-throat by clearing away heat, the effect that the chest stuffiness relieving wets one's whistle.
Chinese patent CN201010503998.9 discloses a kind of Chinese medicine of treating chronic pharyngitis, and its concrete proportioning is: Semen Sterculiae Lychnophorae 50 gram, Flos Chrysanthemi 50 grams, Radix Glycyrrhizae 50 grams, Calyx Seu Fructus Physalis 50 grams, Radix Scutellariae 50 grams, the degree of accuracy of the dose of this medicine be each medicine ± 10%.This medical instrument has relieving sore-throat by clearing away heat, the effect of antiinflammatory expectorant, and is evident in efficacy, the drug effect safety and stability, and cure rate is high, and is without any side effects.
Summary of the invention
To the deficiency of present existence, the invention provides a kind of Chinese medicine composition with function of moistening and cleaning throat.Have good effect, side effect is low, rapid-action characteristics.
The Chinese drug-treated group of Chinese medicine composition of the present invention becomes:
Flos Lonicerae 120-300 Radix Platycodonis 150-375 Fructus Arctii 150-375 Radix Scrophulariae 180-450
Fructus Canarii 150-375 Radix Rehmanniae 150-375 150-375 Radix Ophiopogonis Herba Menthae 150-375
Rhizoma Polygonati 150-375
Preferably, the Chinese medicine of Chinese medicine composition of the present invention composition weight part ratio example is:
Flos Lonicerae 160-240 Radix Platycodonis 200-300 Fructus Arctii 200-300 Radix Scrophulariae 240-360
Fructus Canarii 200-300 Radix Rehmanniae 200-300 200-300 Radix Ophiopogonis Herba Menthae 200-300
Rhizoma Polygonati 200-300
Further preferred, the Chinese medicine of Chinese medicine composition of the present invention is formed the weight part ratio example and is:
Flos Lonicerae 200 Radix Platycodoniss 250 Fructus Arctiis 250 Radix Scrophulariaes 300
Fructus Canarii 250 Radix Rehmanniae Herba Menthae 250 250 Radix Ophiopogonis 250
Rhizoma Polygonati 250
Flos Lonicerae is the alabastrum of the perennial half evergreen prehensile bejuco Radix Ophiopogonis Lonicera japonica Thund. of Caprifoliaceae, has heat-clearing and toxic substances removing, the effect of dispelling wind and heat pathogens.Li Shizhen (1518-1593 A.D.) is claimed in Compendium of Material Medica: " all rheumatism gas, and at toxic swelling, carbuncle scabies, all malignant boil of Fructus Myricae rubrae.The heat radiation detoxifcation.", modern pharmacology shows that these article have broad-spectrum antibacterial action, and pathogenic bacterium such as staphylococcus aureus, dysentery bacterium are had stronger inhibitory action, and several diseases pathogenic microorganisms such as leptospira, influenza virus and pathogenic moulds are also had inhibitory action; Obvious anti-inflammatory and anti and refrigeration function are arranged.
Radix Platycodonis is the root of campanulaceae herbaceos perennial Radix Platycodonis Platycodon grandiflorum (Jaoq.) A.DC..Have lung qi dispersing and eliminate the phlegm, sore-throat relieving, the effect of evacuation of pus.Claim in " pearl sac ": " treat throat pain, sharp lung qi is controlled nasal obstruction ", claim in " book on Chinese herbal medicine is looked for the truth ": " Radix Platycodonis system opens the medicine of lung qi, can be all medicine ships, and is floating on carrying, can draw hardship rush down complete under agent.”。Modern pharmacology shows, these article can reflexive increase the organ secretion, dilution sputum and stronger phlegm-dispelling functions is arranged; Antitussive effect is arranged; Antiinflammatory action is arranged; Can suppress gastric secretion and antiulcer; Also have effects such as spasmolytic, analgesia, calmness, blood sugar lowering, blood fat reducing in addition.
Fructus Arctii is the mature fruit of 2 years these plants of SHENGCAO of Compositae Fructus Arctii Arctium lappa L..Has dispelling wind and heat pathogens, rash sore-throat relieving, the diffusing bullate effect of detoxifcation.Li Shizhen (1518-1593 A.D.) is claimed in Compendium of Material Medica: " speckle removing measles toxin ".Modern pharmacology shows that these article decoct has remarkable antibacterial action to Diplococcus pneumoniae, and analgesic, diuresis is arranged.
Radix Scrophulariae is the root of Scrophulariaceae herbaceos perennial Radix Scrophulariae Scrophularia ningpoensis Hemsl..Have clearing away heat and cooling blood, the effect of YIN nourishing antidotal.Li Shizhen (1518-1593 A.D.) is claimed in Compendium of Material Medica: " nourishing YIN to lower pathogenic fire is separated the speckle poison, throat, diuresis stasis "; Do not claim in " Lu ": " following water ends excessive thirst, the neck nuclear down that looses, carbuncle.”。Modern pharmacology shows that these article have blood vessel dilating, promotes local blood circulation and the effect that diminishes inflammation, and the various skin fungus is had inhibitory action; Bacillus pyocyaneus is also had inhibitory action, external have in the effect of diphtheria toxin, diphtherotoxin.
Fructus Canarii is the dry mature fruit of olive subject plant Fructus Canarii albi Canarium album Raeusch..Have heat clearing away, sore-throat relieving, promote the production of body fluid, the antidotal effect.Modern pharmacology shows that these article have the effect of bacteria growing inhibiting.
Radix Rehmanniae is the root of Scrophulariaceae herbaceos perennial Radix Rehmanniae Rehmannia glutinosa Libosch.Has clearing away heat and cooling blood, the effect of YIN nourishing and the production of body fluid promoting.Claim in " pearl sac ": " the kidney invigorating water is Kidney-Yin for removing heat from blood, hemopoietic ".Modern pharmacology shows that these article have inhibitory action to multiple fungi growth.
Be the root of Liliaceae herbaceos perennial Ophiopogon Radix Ophiopogonis japonicus (L.f.) Ker-Gawl. Radix Ophiopogonis.Have nourishing YIN and moistening the lung, reinforcing stomach reg fluid, the effect of the relieving restlessness that clears away heart-fire.Claim in the supplement to the Herbal: " remove heat in the heart, end dysphoria with smothery sensation.”。Modern pharmacology shows that these article can strengthen reticuloendothelial system phagocytic activity, and the rising peripheral leukocytes improves immunologic function; Various bacteria there is inhibitory action.
Herba Menthae is the stem and leaf of Labiatae herbaceos perennial Herba Menthae Mentha haplocalyx Briq..The effect of dispelling wind and heat pathogens, the clear sharp head, sore-throat relieving, rash, dispersing the stagnated live-QI to relieve the stagnation of QI is arranged.Li Shizhen (1518-1593 A.D.) is claimed in Compendium of Material Medica: " the throat ability to speak is all sick, controls scrofula, skin ulcer scabies, wind scabies urticaria." modern pharmacology shows; these article can be urged skin capillary vascular expansion; can promote the respiratory tract glandular secretion and respiratory inflammation is had therapeutical effect; herpes simplex virus, forest virus, mumps virus are had inhibitory action, staphylococcus aureus, Staphylococcus albus, alpha streptococcus, group B streptococcus, micrococcus catarrhalis, enteritis coccus, shigella flexneri, anthrax bacillus, diphtheria corynebacterium, Bacillus typhi, bacillus pyocyaneus, escherichia coli etc. are had bacteriostasis.
Rhizoma Polygonati is Liliaceae herbaceos perennial Rhizoma Polygonati Polygonatum sibiricum Red. Yunnan Rhizoma Polygonati P.kingianum Coll.et Hemsl or Polygonatum cyrtonema Hua P.cyrtonema Hua rhizome.Function with nourishing kidney lung moistening, invigorating the spleen and replenishing QI.Claim in " book on Chinese herbal medicine justice ": " sweet in the mouth and thick greasy, quite type Radix Rehmanniae Preparata ... enriching blood nourishing YIN and supporting taste is its specialities." modern pharmacology shows that these article have inhibitory action to various bacteria and dermatophytes.
Prescription is mainly according to theory of Chinese medical science, and with reference to the modern pharmacology research data.We are to be guidance with the theory of Chinese medical science, the effective proved recipe that from long-term clinical practice, sums up, and this side's determined curative effect, rapid-action, no toxicity has the good curing effect to pharyngolaryngitis.Evacuate the wind heat of part of the body cavity above the diaphragm housing the heart and lungs women's head-ornaments in the side with Flos Lonicerae, Fructus Arctii, Herba Menthae, assistant is with the pyretic toxicity of removing summer-heat throats such as Radix Scrophulariae, Radix Platycodonis, Fructus Canarii, is aided with the Radix Rehmanniae, Radix Ophiopogonis clearing away heat and nourishing YIN, and all medicines share, and play heat-clearing and toxic substances removing altogether, the effect of dispelling wind and eliminating swelling.
Chinese medicine composition of the present invention can be called clinical acceptable various dosage forms through the preparation process preparation of routine, as: clinical dosage forms commonly used such as granule, tablet, pill, capsule.
The preferred dosage form of Chinese medicine composition of the present invention is a tablet.
The preparation technology of Chinese medicine composition of the present invention is:
Get the Chinese crude drug in the Chinese medicine composition of the present invention; Earlier measure Herba Menthae according to above-mentioned prescription; Extracted volatile oil in steam distillation 2-6 hour, the medical materials of distinguishing the flavor of medicinal residues and all the other Flos Loniceraes, Radix Platycodonis, Rhizoma Polygonati, Fructus Arctii, Radix Scrophulariae, Fructus Canarii, Radix Rehmanniae, Rhizoma Polygonati and Radix Ophiopogonis etc. eight add 8-12 times of water gaging respectively to decoct; Decoct each 0.5-3 hour 2-4 time; Merging filtrate filters, and being concentrated into density is the extractum of 0.8-1.3 (60 ℃ of surveys), and it is dry that extractum adds dextrin, steviosin and mannitol, becomes clinical common formulations according to the common dosage forms prepared.
The preparation technology of Chinese medicine composition of the present invention further is preferably:
Get the Chinese crude drug in the Chinese medicine composition of the present invention; Earlier measure Herba Menthae according to above-mentioned prescription; Steam distillation extracted volatile oil in 3 hours, and the medical materials of distinguishing the flavor of medicinal residues and all the other Flos Loniceraes, Radix Platycodonis, Rhizoma Polygonati, Fructus Arctii, Radix Scrophulariae, Fructus Canarii, Radix Rehmanniae, Rhizoma Polygonati and Radix Ophiopogonis etc. eight add 10 times of water gagings respectively to decoct; Decoct each 1.5 hours 2 times; Merging filtrate filters, and being concentrated into density is the extractum of 1.10-1.20 (60 ℃ of surveys), and it is dry that extractum adds dextrin, steviosin and mannitol, becomes clinical common formulations according to the common dosage forms prepared.
Embodiment
Following examples are used for better setting forth the present invention, only limit to following examples but should not be construed as the present invention.
Embodiment 1
Flos Lonicerae 300 Radix Platycodoniss 150 Fructus Arctiis 150 Radix Scrophulariaes 450
Fructus Canarii 375 Radix Rehmanniae Herba Menthae 375 375 Radix Ophiopogonis 375
Rhizoma Polygonati 375
Get the Chinese crude drug in the Chinese medicine composition of the present invention; Earlier measure Herba Menthae according to above-mentioned prescription; Steam distillation extracted volatile oil in 3 hours, and the medical materials of distinguishing the flavor of medicinal residues and all the other Flos Loniceraes, Radix Platycodonis, Rhizoma Polygonati, Fructus Arctii, Radix Scrophulariae, Fructus Canarii, Radix Rehmanniae, Rhizoma Polygonati and Radix Ophiopogonis etc. eight add 10 times of water gagings respectively to decoct; Decoct each 1 hour 2 times; Merging filtrate filters, and being concentrated into density is the extractum of 1.10-1.15 (60 ℃ of surveys), and it is dry that extractum adds dextrin, steviosin and mannitol, processes granule, and packing promptly gets.
Embodiment 2
Flos Lonicerae 120 Radix Platycodoniss 375 Fructus Arctiis 375 Radix Scrophulariaes 180
Fructus Canarii 375 Radix Rehmanniae Herba Menthae 375 375 Radix Ophiopogonis 375
Rhizoma Polygonati 375
Get the Chinese crude drug in the Chinese medicine composition of the present invention; Earlier measure Herba Menthae according to above-mentioned prescription; Steam distillation extracted volatile oil in 2 hours, and the medical materials of distinguishing the flavor of medicinal residues and all the other Flos Loniceraes, Radix Platycodonis, Rhizoma Polygonati, Fructus Arctii, Radix Scrophulariae, Fructus Canarii, Radix Rehmanniae, Rhizoma Polygonati and Radix Ophiopogonis etc. eight add 12 times of water gagings respectively to decoct; Decoct each 0.5 hour 4 times; Merging filtrate filters, and being concentrated into density is the extractum of 1.15-1.25 (60 ℃ of surveys), and it is dry that extractum adds dextrin, steviosin and mannitol, pulverize, and capsule charge, packing promptly gets.
Embodiment 3
Flos Lonicerae 300 Radix Platycodoniss 375 Fructus Arctiis 375 Radix Scrophulariaes 450
Fructus Canarii 375 Radix Rehmanniae Herba Menthae 150 150 Radix Ophiopogonis 375
Rhizoma Polygonati 375
Get the Chinese crude drug in the Chinese medicine composition of the present invention; Earlier measure Herba Menthae according to above-mentioned prescription; Steam distillation extracted volatile oil in 6 hours, and the medical materials of distinguishing the flavor of medicinal residues and all the other Flos Loniceraes, Radix Platycodonis, Rhizoma Polygonati, Fructus Arctii, Radix Scrophulariae, Fructus Canarii, Radix Rehmanniae, Rhizoma Polygonati and Radix Ophiopogonis etc. eight add 8 times of water gagings respectively to decoct; Decoct each 3 hours 2 times; Merging filtrate filters, and being concentrated into density is the extractum of 1.2-1.3 (60 ℃ of surveys), and it is dry that extractum adds dextrin, steviosin and mannitol, pulverize, and tabletting, packing promptly gets.
Embodiment 4
Flos Lonicerae 300 Radix Platycodoniss 375 Fructus Arctiis 375 Radix Scrophulariaes 450
Fructus Canarii 150 Radix Rehmanniae Herba Menthae 375 375 Radix Ophiopogonis 150
Rhizoma Polygonati 375
Get the Chinese crude drug in the Chinese medicine composition of the present invention; Earlier measure Herba Menthae according to above-mentioned prescription; Steam distillation extracted volatile oil in 4 hours, and the medical materials of distinguishing the flavor of medicinal residues and all the other Flos Loniceraes, Radix Platycodonis, Rhizoma Polygonati, Fructus Arctii, Radix Scrophulariae, Fructus Canarii, Radix Rehmanniae, Rhizoma Polygonati and Radix Ophiopogonis etc. eight add 9 times of water gagings respectively to decoct; Decoct each 1 hour 3 times; Merging filtrate filters, and being concentrated into density is the extractum of 0.8-1.1 (60 ℃ of surveys), and it is dry that extractum adds dextrin, steviosin and mannitol, pill, and packing promptly gets.
Embodiment 5
Flos Lonicerae 300 Radix Platycodoniss 375 Fructus Arctiis 375 Radix Scrophulariaes 450
Fructus Canarii 375 Radix Rehmanniae Herba Menthae 375 375 Radix Ophiopogonis 375
Rhizoma Polygonati 150
Get the Chinese crude drug in the Chinese medicine composition of the present invention; Earlier measure Herba Menthae according to above-mentioned prescription; Steam distillation extracted volatile oil in 5 hours, and the medical materials of distinguishing the flavor of medicinal residues and all the other Flos Loniceraes, Radix Platycodonis, Rhizoma Polygonati, Fructus Arctii, Radix Scrophulariae, Fructus Canarii, Radix Rehmanniae, Rhizoma Polygonati and Radix Ophiopogonis etc. eight add 11 times of water gagings respectively to decoct; Decoct each 1.5 hours 3 times; Merging filtrate filters, and being concentrated into density is the extractum of 1.05-1.2 (60 ℃ of surveys), and it is dry that extractum adds dextrin, steviosin and mannitol, and packing promptly gets powder.
Embodiment 6
Flos Lonicerae 200 Radix Platycodoniss 250 Fructus Arctiis 250 Radix Scrophulariaes 300
Fructus Canarii 250 Radix Rehmanniae Herba Menthae 250 250 Radix Ophiopogonis 250
Rhizoma Polygonati 250
Get the Chinese crude drug in the Chinese medicine composition of the present invention; Earlier measure Herba Menthae according to above-mentioned prescription; Steam distillation extracted volatile oil in 3 hours, and the medical materials of distinguishing the flavor of medicinal residues and all the other Flos Loniceraes, Radix Platycodonis, Rhizoma Polygonati, Fructus Arctii, Radix Scrophulariae, Fructus Canarii, Radix Rehmanniae, Rhizoma Polygonati and Radix Ophiopogonis etc. eight add 10 times of water gagings respectively to decoct; Decoct each 2 hours 2 times; Merging filtrate filters, and being concentrated into density is the extractum of 1.1-1.2 (60 ℃ of surveys), and it is dry that extractum adds dextrin, steviosin and mannitol, becomes clinical common formulations according to the common dosage forms prepared.
Embodiment 7
Flos Lonicerae 160 Radix Platycodoniss 200 Fructus Arctiis 300 Radix Scrophulariaes 360
Fructus Canarii 300 Radix Rehmanniae Herba Menthae 300 200 Radix Ophiopogonis 300
Rhizoma Polygonati 300
Get the Chinese crude drug in the Chinese medicine composition of the present invention; Earlier measure Herba Menthae according to above-mentioned prescription; Steam distillation extracted volatile oil in 4 hours, and the medical materials of distinguishing the flavor of medicinal residues and all the other Flos Loniceraes, Radix Platycodonis, Rhizoma Polygonati, Fructus Arctii, Radix Scrophulariae, Fructus Canarii, Radix Rehmanniae, Rhizoma Polygonati and Radix Ophiopogonis etc. eight add 10 times of water gagings respectively to decoct; Decoct each 1 hour 3 times; Merging filtrate filters, and being concentrated into density is the extractum of 1.15-1.25 (60 ℃ of surveys), and it is dry that extractum adds dextrin, steviosin and mannitol, spraying one step pelletize, and packing promptly gets.
Embodiment 8
Flos Lonicerae 240 Radix Platycodoniss 300 Fructus Arctiis 200 Radix Scrophulariaes 240
Fructus Canarii 300 Radix Rehmanniae Herba Menthae 300 300 Radix Ophiopogonis 200
Rhizoma Polygonati 300
Get the Chinese crude drug in the Chinese medicine composition of the present invention; Earlier measure Herba Menthae according to above-mentioned prescription; Steam distillation extracted volatile oil in 3 hours, and the medical materials of distinguishing the flavor of medicinal residues and all the other Flos Loniceraes, Radix Platycodonis, Rhizoma Polygonati, Fructus Arctii, Radix Scrophulariae, Fructus Canarii, Radix Rehmanniae, Rhizoma Polygonati and Radix Ophiopogonis etc. eight add 9 times of water gagings respectively to decoct; Decoct each 2 hours 2 times; Merging filtrate filters, and being concentrated into density is the extractum of 1.10-1.20 (60 ℃ of surveys), and it is dry that extractum adds dextrin, steviosin and mannitol, becomes clinical common formulations according to the common dosage forms prepared.
Embodiment 9
Flos Lonicerae 240 Radix Platycodoniss 300 Fructus Arctiis 300 Radix Scrophulariaes 360
Fructus Canarii 200 Radix Rehmanniae Herba Menthae 200 300 Radix Ophiopogonis 300
Rhizoma Polygonati 200
Get the Chinese crude drug in the Chinese medicine composition of the present invention; Earlier measure Herba Menthae according to above-mentioned prescription; Steam distillation extracted volatile oil in 4 hours, and the medical materials of distinguishing the flavor of medicinal residues and all the other Flos Loniceraes, Radix Platycodonis, Rhizoma Polygonati, Fructus Arctii, Radix Scrophulariae, Fructus Canarii, Radix Rehmanniae, Rhizoma Polygonati and Radix Ophiopogonis etc. eight add 11 times of water gagings respectively to decoct; Decoct each 1 hour 2 times; Merging filtrate filters, and being concentrated into density is the extractum of 1.15-1.25 (60 ℃ of surveys), and it is dry that extractum adds dextrin, steviosin and mannitol, a step pelletize, and tabletting, packing promptly gets.
Embodiment 10 pharmacodynamic experiments
Medicine xylol of the present invention causes the influence of Mice Auricle inflammatory swelling
1, medicine and reagent
The extractum of the arbitrary acquisition of embodiment 1-7 faces with preceding and is made into desired concn with distilled water, is thick solution; Xylene, middle Sheng chemical industry company limited; Prednisone acetate tablets, Henan Lihua Pharmaceutical Co., Ltd.
2, animal
Kunming mouse, Shandong University's Experimental Animal Center
3, method
Get 60 of the male mices of body weight 20 ± 2 gram, be divided into 5 groups at random: normal saline, prednisolone acetate 0.008g/kg, medicine 7.5g of the present invention, 15g, 30g crude drug/kg, each organizes continuous gastric infusion three days; The 4th day gastric infusion was applied to two sides, ear front and back, a mice left side, every 0.1ml with xylene after 30 minutes; Put to death mice after 4 hours, with the auricle same area punching in the left and right sides of 9mm card punch, the both sides auricle is weighed respectively; With the swelling rate as the swelling level index; By formula calculate, the difference between comparative drug group and matched group, the result sees the following form.
Table 1 medicine xylol of the present invention causes the influence of Mice Auricle inflammatory swelling
* p＜0.05, * * p＜0.01 and the comparison of normal saline group.
Embodiment 11 pharmacodynamic experiments
Medicine of the present invention is to the influence of rat carrageenan property pedal swelling
1, medicine and reagent
The extractum of the arbitrary acquisition of embodiment 1-7 faces with preceding and is made into desired concn with distilled water, is thick solution; Xylene, middle Sheng chemical industry company limited; Prednisone acetate tablets, Henan Lihua Pharmaceutical Co., Ltd.
2, animal
The Wistar rat, Shandong University's Experimental Animal Center
3, method
50 of male Wistar rats are selected in experiment for use, and body weight 200～240g is divided into 5 groups every group 10 at random, are prednisolone acetate group, normal saline matched group and high, medium and low three dose groups of medicine of the present invention.What each group was given corresponding content receives reagent 1 time/day, continuous 7 days.Earlier measure right back sufficient sole of the foot volume after the last administration, and mark with volumetric method.Again in right back sufficient plantar subcutaneous injection 1% carrageenin 0.1ml, and used with quadrat method in mark in 1,3,5 hour in the injection back and to survey sufficient sole of the foot volume, deduct the administration front volume and be sufficient pawl swelling degree, the result is after statistical procedures, and the result sees the following form.
Table 2 medicine of the present invention is to the influence of rat carrageenan property pedal swelling
Compare * P＜0.05, * * P＜0.01 with model control group.
Embodiment 11 pharmacodynamic experiments
Medicine of the present invention is to the bullate influence of rat rat granuloma
1, medicine and reagent
The extractum of the arbitrary acquisition of embodiment 1-7 faces with preceding and is made into desired concn with distilled water, is thick solution; Prednisone acetate tablets, Henan Lihua Pharmaceutical Co., Ltd.
2, animal
The SD rat, Shandong University's Experimental Animal Center
3, method
Get 60 of the male rats of body weight 200 ± 20 gram, under ether light anaesthesia aseptic condition, make abdominal incision, with the cotton balls (about 50mg) after the oven dry in the baking oven of 50 degrees centigrade of autoclavings of having weighed, implantation rat both sides axillary region is subcutaneous.Be divided into 5 groups at random: normal saline, prednisolone acetate 0.028g/kg, medicine of the present invention 0.607,1.215,2.43g crude drug/kg, each organizes continuous gastric infusion seven days, granulation tissue is peeled off and taken out in rat execution in the 8th day.In 60 degrees centigrade drying in oven, deduct the raw cotton ball weight, be the granuloma net weight.Respectively organize granuloma weight.And calculating suppression ratio.
Table 3 medicine of the present invention is to the bullate influence of rat granuloma
* p＜0.05, * * p＜0.01 and the comparison of normal saline group.
Claims (5)
1. Chinese medicine composition with function of moistening and cleaning throat is characterized in that Chinese crude drug forms the weight portion ratio and be:
Flos Lonicerae 120-300 Radix Platycodonis 150-375 Fructus Arctii 150-375 Radix Scrophulariae 180-450
Fructus Canarii 150-375 Radix Rehmanniae 150-375 150-375 Radix Ophiopogonis Herba Menthae 150-375
Rhizoma Polygonati 150-375.
2. Chinese medicine composition as claimed in claim 1 is characterized in that Chinese crude drug composition weight portion ratio is:
Flos Lonicerae 160-240 Radix Platycodonis 200-300 Fructus Arctii 200-300 Radix Scrophulariae 240-360
Fructus Canarii 200-300 Radix Rehmanniae 200-300 200-300 Radix Ophiopogonis Herba Menthae 200-300
Rhizoma Polygonati 200-300.
3. Chinese medicine composition as claimed in claim 2 is characterized in that Chinese crude drug composition weight portion ratio is:
Flos Lonicerae 200 Radix Platycodoniss 250 Fructus Arctiis 250 Radix Scrophulariaes 300
Fructus Canarii 250 Radix Rehmanniae Herba Menthae 250 250 Radix Ophiopogonis 250
Rhizoma Polygonati 250.
4. the arbitrary described Chinese medicine composition of claim 1-3, its preparation technology is:
Get the Chinese crude drug in the Chinese medicine composition of the present invention; Earlier measure Herba Menthae according to above-mentioned prescription; Extracted volatile oil in steam distillation 2-6 hour, the medical materials of distinguishing the flavor of medicinal residues and all the other Flos Loniceraes, Radix Platycodonis, Rhizoma Polygonati, Fructus Arctii, Radix Scrophulariae, Fructus Canarii, Radix Rehmanniae, Rhizoma Polygonati and Radix Ophiopogonis etc. eight add 8-12 times of water gaging respectively to decoct; Decoct each 0.5-3 hour 2-4 time; Merging filtrate filters, and being concentrated into density is the extractum of 0.8-1.3 (60 ℃ of surveys), and it is dry that extractum adds dextrin, steviosin and mannitol, becomes clinical common formulations according to the common dosage forms prepared.
5. Chinese medicine composition as claimed in claim 4, its preparation technology is:
Get the Chinese crude drug in the Chinese medicine composition of the present invention; Earlier measure Herba Menthae according to above-mentioned prescription; Steam distillation extracted volatile oil in 3 hours, and the medical materials of distinguishing the flavor of medicinal residues and all the other Flos Loniceraes, Radix Platycodonis, Rhizoma Polygonati, Fructus Arctii, Radix Scrophulariae, Fructus Canarii, Radix Rehmanniae, Rhizoma Polygonati and Radix Ophiopogonis etc. eight add 10 times of water gagings respectively to decoct; Decoct each 1.5 hours 2 times; Merging filtrate filters, and being concentrated into density is the extractum of 1.10-1.20 (60 ℃ of surveys), and it is dry that extractum adds dextrin, steviosin and mannitol, becomes clinical common formulations according to the common dosage forms prepared.
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