CN106038995A - Traditional Chinese medicine granules for treating perioral dermatitis and preparation method - Google Patents

Abstract

The invention discloses traditional Chinese medicine granules for treating perioral dermatitis and a preparation method, and belongs to the field of traditional Chinese medicines. Active ingredients of the traditional Chinese medicine granules provided by the invention are prepared from the following raw materials: folium brassicae campestris, green gram starch, radix astragali, folium broussonetia kazinoki, radix sanguisorbae, radix ophiopogonis, radix scutellariae, herba portulacae, radix scrophulariae, fructus lycii, radix glycyrrhizae, fructus ligustri lucidi, radix polygonati officinalis, Australian cowplant root or leaf, herba artemisiae scopariae, cortex dictamni, bulbus lilii, Japanese pagodatree bark, radix puerariae, herba gentianae rhodanthae, rhizoma anemarrhenae, flos campsis, herba ixeris chinensis and herba andrographis. The traditional Chinese medicine granules are prepared from medicinal materials consistent with basic principles of compatibility composition, are applied according to indications, have functions of clearing away heat and purging fire, cooling blood and eliminating toxins, expelling wind and relieving itching, expelling pus and dispersing swelling, regenerating tissues to heal sores, nourishing yin and moisturizing lung, nourishing stomach to improve the production of body fluid, have good absorption effect, significant curative effect, no toxic and side effects and no clinical adverse reactions, and are clinically proven to have higher cure rate for perioral dermatitis.

Description

A kind of instant particles as Chinese medicine for treating Perioral Dermatitis and preparation method

Art

The present invention relates to the field of Chinese medicines, particularly relate to a kind of instant particles as Chinese medicine for treating Perioral Dermatitis and preparation method.

Background technology

What Perioral Dermatitis was to occur at upper lip, chin, nasolabial fold, nose etc. is the main inflammation showed with erythema, pimple, squama Disease dermatoses.Primary disease more than 90% is women, and the age, skin lesion was scattered 1～2 mm in sizes typically between 23～35 years old Pimple, papulovesicle, substrate is red or merges in flakes.Also visible scattered little papulopustule, has slight squama.The most symmetrical, at skin Between damage and vermilion border, the skin area around about 5 mm wides is not got involved.The course of disease is periodical attack, can be with light to moderate Pruritus and burn feeling.

Perioral Dermatitis pathogenesis is the most not clear.It is believed that the 17-hydroxy-11-dehydrocorticosterone being fluorine-containing with fluorine-containing is relevant, but all It is not finalized.Doctor trained in Western medicine presently mainly uses Drug therapy, first stops using toothpaste with fluoride and fluorine-containing corticosteroid hormone. Avoid all exogenous stimulations.Tetracycline takes orally, 0.25g/ time, 2～4 times/d, is used in conjunction 6 weeks；If being in a bad way, 0.25g/ time, 4 Secondary/d.Though western medicine has certain curative effect, but the state of an illness easily recurs.

Perioral Dermatitis, for the name of disease of doctor trained in Western medicine, belongs to the models such as " skin ulcer rash ", " herpes simplex ", " exfoliative inflammation of the lips ", " lip cocoon " in the traditional Chinese medical science Farmland, sick position, at lung stomach, how because of the evil invasion and attack of burning hot poison, in long underlying mass, causes damp and hot interior life, and lung loses in evacuation, and taste are stranded by damp and hot, Two heresies are fought mutually, leap up under upper steaming, exuberant skin and send out in lip.Chinese traditional treatment Perioral Dermatitis is many to expel the heat-evil based on hardship fall, but too much The product throwing clearing up internal heat by using drugs of bitter in taste and cold in nature, and think little of the lung moistening and production of body fluid promoting, invigorating spleen and reinforcing stomach, often resulting in lung meridian has heat, damp and hot interior tired taste, can cause Internal organs body fluid loses, and adds overabundant yin liquid virtual loss, makes deficiency-fire produced in the interior, disease difficulty remove.The present invention is through long-term clinical practice, according to the cause of disease pair Disease is put in poison, and has clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body, dispelling wind for relieving itching, evacuation of pus detumescence, promoting tissue regeneration and ulcer healing, nourishing YIN and moistening the lung, the merit of nourishing the stomach to promote the production of body fluid Effect, selected herbal nature is suitable mutually auxiliary mutually, has heat clearing away not impairment of YIN, YIN nourishing does not help the merit of heat, good absorbing effect, evident in efficacy, nothing Toxic and side effects and clinical adverse are higher to Perioral Dermatitis cure rate according to clinical verification.

Summary of the invention

The invention provides a kind of instant particles as Chinese medicine for treating Perioral Dermatitis and preparation method, there is clearing away heat-fire, cool Blood removing toxic substances, dispelling wind for relieving itching, evacuation of pus detumescence, promoting tissue regeneration and ulcer healing, nourishing YIN and moistening the lung, effect of nourishing the stomach to promote the production of body fluid, cure the disease and seek source treating both the principal and secondary aspects of a disease, right The Perioral Dermatitis that a variety of causes causes is respectively provided with good curative effect.

For achieving the above object, technical scheme is implemented as follows:

A kind of instant particles as Chinese medicine for treating Perioral Dermatitis, makes raw material composition and the weight portion of described effective ingredient Number is:

Caulis et Folium Brassicae campestris 65～80 parts, Semen phaseoli radiati powder 62～77 parts, the Radix Astragali 59～74 parts, little leaf of Broussonetia papyrifera (L.) L.Her.ex Vent. 56～71 parts,

Radix Sanguisorbae 53～68 parts, Radix Ophiopogonis 50～65 parts, Radix Scutellariae 46～62 parts, Herba portulacae 43～59 parts,

Radix Scrophulariae 40～56 parts, Fructus Lycii 37～53 parts, Radix Glycyrrhizae 34～50 parts, Fructus Ligustri Lucidi 31～47 parts,

Rhizoma Polygonati Odorati 28～43 parts, Radix Gymnematis Sylvestris 25～40 parts, Herba Artemisiae Scopariae 22～36 parts, Cortex Dictamni 19～33 parts,

Bulbus Lilii 16～30 parts, Cortex sophorae 13～27 parts, Radix Puerariae 10～23 parts, Gentiana rhodantha Franch. 8～20 parts,

The Rhizoma Anemarrhenae 6～18 parts, Flos Campsis 4～15 parts, Herba Ixeritis chinensis 2～12 parts, Herba Andrographis 1～9 parts.

Make described effective ingredient raw material composition and parts by weight be:

Caulis et Folium Brassicae campestris 68～77 parts, Semen phaseoli radiati powder 65～74 parts, the Radix Astragali 62～71 parts, little leaf of Broussonetia papyrifera (L.) L.Her.ex Vent. 59～68 parts,

Radix Sanguisorbae 56～65 parts, Radix Ophiopogonis 53～62 parts, Radix Scutellariae 49～59 parts, Herba portulacae 46～56 parts,

Radix Scrophulariae 43～53 parts, Fructus Lycii 40～50 parts, Radix Glycyrrhizae 37～47 parts, Fructus Ligustri Lucidi 34～44 parts,

Rhizoma Polygonati Odorati 31～40 parts, Radix Gymnematis Sylvestris 28～37 parts, Herba Artemisiae Scopariae 25～33 parts, Cortex Dictamni 22～30 parts,

Bulbus Lilii 19～27 parts, Cortex sophorae 16～24 parts, Radix Puerariae 13～20 parts, Gentiana rhodantha Franch. 11～17 parts,

The Rhizoma Anemarrhenae 8～15 parts, Flos Campsis 6～12 parts, Herba Ixeritis chinensis 4～10 parts, Herba Andrographis 3～7 parts.

Make described effective ingredient raw material composition and parts by weight be:

Caulis et Folium Brassicae campestris 74 parts, Semen phaseoli radiati powder 70 parts, the Radix Astragali 67 parts, little leaf of Broussonetia papyrifera (L.) L.Her.ex Vent. 64 parts,

Radix Sanguisorbae 61 parts, Radix Ophiopogonis 58 parts, Radix Scutellariae 54 parts, Herba portulacae 51 parts,

Radix Scrophulariae 48 parts, Fructus Lycii 45 parts, 42 parts of Radix Glycyrrhizae, Fructus Ligustri Lucidi 39 parts,

Rhizoma Polygonati Odorati 36 parts, Radix Gymnematis Sylvestris 32 parts, Herba Artemisiae Scopariae 29 parts, Cortex Dictamni 26 parts,

Bulbus Lilii 23 parts, Cortex sophorae 20 parts, Radix Puerariae 17 parts, Gentiana rhodantha Franch. 14 parts,

The Rhizoma Anemarrhenae 11 parts, Flos Campsis 9 parts, Herba Ixeritis chinensis 6 parts, Herba Andrographis 4 parts.

The preparation method of a kind of instant particles as Chinese medicine for treating Perioral Dermatitis, comprises the following steps that:

(1) by white to Caulis et Folium Brassicae campestris, Semen phaseoli radiati powder, little leaf of Broussonetia papyrifera (L.) L.Her.ex Vent., Radix Sanguisorbae, Radix Ophiopogonis, Herba portulacae, Radix Gymnematis Sylvestris, Herba Artemisiae Scopariae, Cortex Dictamni, Chinese scholartree Skin, Radix Puerariae, Flos Campsis, Herba Ixeritis chinensis Gentiana rhodantha Franch. are cleaned, are dried rear mix homogeneously, put in container, add 6～8 in a reservoir The water of times amount, heated and boiled 2～3 hours, take immersion after cooling；The water of 4～6 times amount is added, heating in remaining medicinal residues Boil 1～2 hour, after cooling, take immersion；Merging twice gained immersion, heating, evaporation and concentration is relative density 1.15～1.25 Thick paste, standby；

(2) Radix Scrophulariae, Fructus Lycii, Rhizoma Polygonati Odorati are put in container, add the shao-hsing rice wine of 3～5 times amount, cool after boiling, continue Continuous immersion 3～5 hours, takes immersion；In remaining medicinal residues, add the shao-hsing rice wine of 2～4 times amount, put after boiling and dry in the air, continue Soak 2～4 hours, take immersion；Merge twice gained immersion, add and steam the thick paste that evaporation and concentration is relative density 1.10～1.20, Standby；

(3) astragalus mongholicus tablet is added cooked Mel and a little boiled water, mixes thoroughly the most vexed, fry in putting pot to yellow and tack-free time, Taking-up is dried in the air cool, and pulverizing is ground into powder, crosses 100 mesh dusting covers, obtains fine powder, standby；

(4) take scutellaria tablet to mix thoroughly with a certain amount of yellow wine, slightly moistening, after yellow wine is sucked, put in parch container, with literary composition Fire fried dry, taking-up cools, and pulverizing is ground into powder, crosses 100 mesh dusting covers, obtains fine powder, standby；

(5) take clean Radix Glycyrrhizae tabellae, add cooked Mel and a little boiled water, the most vexed after mixing thoroughly, to put in parch container, slow fire is fried To buff, taking out, cool time tack-free, pulverizing is ground into powder, crosses 100 mesh dusting covers, obtains fine powder, standby；

(6) take clean Fructus Ligustri Lucidi to add yellow wine and mix thoroughly, put in appropriate vessel, airtight, to sit in kettle, stewing out of water to wine exhausts, and takes Go out, dry, pulverize and grind into powder, cross 100 mesh dusting covers, obtain fine powder, standby；

(7) take clean Bulbus Lilii, when frying to color burn with slow fire, add the refined honey diluted with a little boiled water, stir rapidly, Stirring uniformly, continuation slow fire is fried to time slightly yellow, tack-free, and taking-up cools, and pulverizing is ground into powder, crosses 100 mesh dusting covers, obtains fine powder, Standby；

(8) taking Rhizoma Anemarrhenae sheet to put in pot with the micro-stir-fry of slow fire, spray saline, take out and cool after fried dry, pulverizing is ground into powder, crosses 100 mesh Dusting cover, obtains fine powder, standby；

(9) by after clean for Herba Andrographis drying, pulverizing is ground into powder, crosses 100 mesh dusting covers, obtains fine powder, standby；

(10) by step (1), the thick paste of step (2) gained, with step (3), step (4), step (5), step (6), step Suddenly the fine powder mixing of gained in (7), step (8), step (9), adds adjuvant sucrose and dextrin mix homogeneously makes granule, be dried, After granulate, it is packaged into the instant particles as Chinese medicine of every bag of 12g.

The property of medicine of Chinese medicine used by the present invention is as follows:

Caulis et Folium Brassicae campestris: acrid in the mouth；Sweet；Property flat.Lung；Liver；Spleen channel.Removing pathogenic heat from blood and dissipating blood stasis；Removing toxic substances and promoting subsidence of swelling.Cure mainly dysentery；Erysipelas；Pyretic toxicity skin ulcer Swollen；Acute mastitis；Rubella；Spit blood.Compendium of Material Medica: control panaris, smallpox, dissipates blood detumescence.

Semen phaseoli radiati powder: sweet in the mouth；Cold in nature.Return stomach；Intestinal；Liver Channel.Clearing away heat and removing summer；Removing pathogenic heat from blood and toxic substance from the body.Cure mainly summer-heat excessive thirst；Carbuncle skin ulcer Infections；Erysipelas；Burn and scald；Traumatic injury；Discharging fresh blood stool；Alcoholism." Bencao Jingshu ": the reported abnormal smells from the patient of Semen phaseoli radiati powder is same with Semen phaseoli radiati, therefore energy Solve all heat and food and drink is malicious, burn burns also.Carbuncle on the back, carbuncle, skin ulcer are swollen, and all caused by pyretic toxicity, the heat that sweet cold solution sun is bright, then poison is unlikely Violating stomach and vomiting and nausea, the intestines and stomach is refrigerant, and all swollen dissipates.Heat impairing vital QI, heat extraction event energy QI invigorating is also.

The Radix Astragali: sweet in the mouth；Warm in nature.Enter the heart；Lung；Spleen；Kidney channel.Invigorating QI to consolidate the body surface resistance；Diuresis；Expelling pus and toxin by strengthening QI；Promoting tissue regeneration and ulcer healing.Cure mainly gas Short cardiopalmus；Asthenia；Weak；Spontaneous perspiration；Night sweat；Chronic diarrhea；Proctoptosis；Body is impractical swollen；Uterine prolapse；Chronic nephritis；Carbuncle difficulty is burst；Or burst Do not hold back for a long time." Xinhua's book on Chinese herbal medicine outline " carries: " have the function of invigorating QI to consolidate the body surface resistance, expelling pus and toxin by strengthening QI, granulation promoting." modern medicine study confirmation, yellow Stilbene has diuretic antihypertensive, anti-inflammatory analgesic, heart tonifying, antioxidant radical generation and improves the multiple pharmacological effect such as body's immunity, Body can be acted on from many aspects, improve the relevant blood vessel sexually transmitted disease (STD)s such as cardiovascular, cerebrovascular, diabetes, nephropathy and become the blood flow of patient The function such as kinetics and vascular endothelial cell.

Little leaf of Broussonetia papyrifera (L.) L.Her.ex Vent.: lightly seasoned；Cool in nature.Heat-clearing and toxic substances removing；Dispelling wind for relieving itching；Sore is stopped blooding.Cure mainly dysentery；Neurodermatitis；Scabies Tinea；Furuncle and phyma；Knife injury is hemorrhage.

Radix Sanguisorbae: bitter in the mouth；Acid；Cold in nature, nontoxic.Enter liver；Lung；Kidney；Large intestine channel.Cooling blood for hemostasis；Heat-clearing and toxic substances removing；Detumescence sore. Cure mainly haematemesis；Spitting of blood；Epistaxis；Hematuria；Have blood in stool；Hemorrhoidal bleeding；Dysentery；Metrorrhagia；Leucorrhea with red and white discharge；Sore, carbuncle and painful swelling；Eczema；Pudendal pruritus；Extreme misery Scald and burn；Snake bite and insect sting." not Lu " carries: " only pus and blood, all flaccidity, malignant boil, disappear wine, except quenching one's thirst, mends plug in wound, puerperal absolutely, can make incised wound Cream, main internal hemorrhage due to trauma is more than, insufficiency of blood." modern medicine study confirmation, Radix Sanguisorbae has hemostasis, antiinflammatory action, has stronger convergence, Energy vasoconstrictive, reduces the permeability of blood vessel, reduces inflammatory exudation, and Radix Sanguisorbae is to escherichia coli, bacterium sonnei, deformation simultaneously Bacillus, Bacillus typhi, Salmonella paratyphi, bacillus pyocyaneus, vibrio cholera, tubercule bacillus, meningococcus etc. have antibacterial action.

Radix Ophiopogonis: sweet in the mouth；Micro-hardship；Cold in nature.Return lung；Stomach；Heart channel.Nourishing YIN and moistening the lung；Reinforcing stomach reg fluid；Clear away heart-fire relieving restlessness.Cure mainly lung Dry dry cough；Lung abscess；Deficiency of YIN chronic cough；Tianjin wound is thirsty；Quench one's thirst；Vexed insomnia；Have sore throat；Dryness of the intestine constipation；Heat in blood tells nosebleed." book on Chinese herbal medicine Converge and say ": Radix Ophiopogonis, the medicine of clearing away heart-fire and moistening the lung is also.Main deficiency of heart-QI, palpitate with fear palpitation with a distress feeling, forgetful dimly, spirit fall；Or the lung-heat dryness of the lung, Coughing sound running fire, consumptive lung disease leaf scorch, dyspnea due to deficiency of losing heart, fire lies prostrate in lung, hemoptysis of spitting blood；Or asthenia exopathogenic heat, body fluid is dry few；Or taste are dry dries up, Constipation due to insufficiency dyschezia；This card that all cardiopulmonary kidney spleen unit asthenic fire is strongly fragrant is also.But sweet in the mouth gas is put down, energy lung benefiting gold, bitter in the mouth is cold in nature, can drop heart-fire, Body profit matter is mended, and can support medulla renis, and the merit specially controlling strain deficiency-heat is in the majority.Stagnation of QI in chest and abdomen as main in front Gu, damaging the spleen and stomach wound is full, and stomach channels is exhausted, thin The thin disease such as lose heart, then belong to strain bright.

Radix Scutellariae: bitter in the mouth；Cold in nature.Return lung；Gallbladder；Spleen；Stomach；Large intestine；Small intestine meridian.Heat clearing and damp drying；Eliminating fire and detoxication；Arresting bleeding and miscarriage prevention； Blood pressure lowering.Cure mainly hygropyrexia, heat-damp in summer vomiting and nausea uncomfortable in chest；Damp and hot feeling of fullness；Dysentery；Jaundice；Cough due to lung-heat；Heat in blood tells nosebleed；Carbuncle sore tumefacting virus；Tire Dynamic uneasiness." herbal classic " carries: " main all hot jaundice, intestinal is out-of-the-way, lets out profit, relieves oedema or abdominal distension through diuresis or purgation, and hematochezia closes, malignant boil, and cellulitis is lost, acute scleritis." modern medicine grinds Studying carefully confirmation, Radix Scutellariae has the effects such as the most antibacterial, antifungal, antiviral, antiinflammatory, antiallergic action, can reduce blood pressure, suppress blood Platelet gathering, anticoagulant, blood fat reducing, in addition with protecting the liver, function of gallbladder promoting, antioxidation, anticancer function.

Herba portulacae: acrid in the mouth；Acid；Cold in nature；Nontoxic.Enter large intestine, liver, spleen channel.Heat-clearing and toxic substances removing；Cooling blood for hemostasis；Dissipate blood detumescence.Main Control skin infection carbuncle furuncle；Scrofula；Temperature tinea.Tang Materia Medica carries: " main all swollen fistula verruca." Herba portulacae be usually used in reduce inflammation, especially suitable In inflammatory skin, can be effectively increased the oxidation resistance of Skin Cell, reduce inflammation symptom.

Radix Scrophulariae: sweet in the mouth；Bitter；Salty；Cold nature.Return lung；Stomach；Kidney channel.Clearing away heat and cooling blood；Nourishing YIN to lower pathogenic fire；Detoxicating and resolving stagnation of pathogens.Cure mainly temperature Calentura heat and nutrient blood；Fever of the body；Excessive thirst；Crimson tongue；Send out speckle；Hectic fever due to YIN-deficiency chronic cough；Fidgets due to deficiency not awake；Constipation is hindered in Tianjin；Mesh is puckery dim-sighted；Swelling throat Bitterly；Scrofula sucutaneous nodule；Skin sore." Japan hanako materia medica " carries: " controlling wind syndrome of head pyretic toxicity urticaria, qi-restoratives strains, the frightened agitation of the heart, bad weary bone Steam, pass corpse pathogen, the most forgetful, detumescence poison." modern medicine study confirmation, Radix Scrophulariae is containing Radix Scrophulariae element, iridoid glycosides, also containing waving Hair oil, alkaloid etc., infusion, alcohol immersion and decoct have the effect reduced blood pressure, can expand blood vessel, heart tonifying, in addition with Town table and anticonvulsant action.

Fructus Lycii: sweet in the mouth；Property flat.Return liver；Kidney；Lung meridian.Nourishing the liver；Nourishing kidney；Lung moistening.Cure mainly caused by liver and kidney deficiency；Have a dizzy spell；Mesh Clear depending on one；Soreness of the waist and knees；The expensive essence of sexual impotence；Cough due to consumptive disease；Quench one's thirst taking fluids profusely." book on Chinese herbal medicine is just " carries: " bright knowledge, adds the solid marrow of essence, and strong bone is strong Muscle, kind benefit impairment caused by overstrain, the most only quench one's thirst." modern medicine study confirms, Fructus Lycii scalable body's immunity, can effectively suppress swollen Tumor growth and cell mutation, have slow down aging, anti-fatty liver, regulation blood fat and the work of the aspect such as blood glucose, promotion hemopoietic function With.

Radix Glycyrrhizae: sweet in the mouth；Property flat.GUIXIN；Lung；Spleen；Stomach warp.Invigorating the spleen and replenishing QI；Heat-clearing and toxic substances removing；Expelling phlegm for arresting cough；Relieving spasm to stop pain；Adjust With all medicines.Cure mainly weakness of the spleen and stomach；Fatigue and weakness；Shortness of breath and palpitation；Cough with copious phlegm；Gastral cavity abdomen extremity contraction urgency pain；Carbuncle sore tumefacting virus；Alleviate Drug toxicity.Compendium of Material Medica carries: " in all medicines, Radix Glycyrrhizae is monarch.Control 72 kinds of mammary calculus poison, solution 1,002 poison of draft by every means, adjust Gain merit with from medicine." modern medicine study confirms, Radix Glycyrrhizae has a stronger Detoxication, also antiulcer, anti-inflammatory, spasmolytic antitussive, Lowering blood pressure and blood fat, antitumaous effect, be widely used in treatment pharyngolaryngitis, laryngitis, tracheitis, bronchitis, asthma, cough, hemoptysis Etc. disease, additionally there is anti-gastric-ulcer, gastritis effect.

Fructus Ligustri Lucidi: bitter in the mouth；Cool in nature.Return liver；Kidney channel.Tonifying liver kidney yin, crow must improving eyesight.Cure mainly the hepatic and renal YIN deficiency；Soreness of waist tinnitus；Palpus Send out the whitest；Unseeing；Fever due to yin deficiency；Gastropathy and gout and hyperuricemia." book on Chinese herbal medicine is the newest ": replenishing YIN to strengthen the kidney, QI invigorating soothing liver-QI. Control lumbago and skelalgia, stimulate the menstrual flow and blood.Modern medicine study proves, Fructus Ligustri Lucidi has a blood fat reducing, atherosclerosis, heart tonifying, diuresis, Cough-relieving, cathartic, antibacterial and hepatoprotective effect, can improve peripheral leukocytes, strengthen reticuloendothelial system phagocytic activity, have enhancing cell Immunity and the effect of humoral immunization, have rising effect to the leukopenia caused because of chemotherapy or radiotherapy, can suppress animal some The growth of transplanted tumor.

Rhizoma Polygonati Odorati: sweet in the mouth；Property flat.Enter lung；Stomach warp.Nourishing YIN and moistening the lung；Nourishing the stomach to promote the production of body fluid.Cure mainly cough caused by dryness；Chronic cough；Calentura the moon liquid consumption wound Dry throat and mouth；Interior-heat is quenched one's thirst；Deficiency of YIN diseases caused by exogenous pathogenic factor；Dizzy dizziness；Muscle arteries and veins spasm and pain." Japan hanako materia medica " carries: " relieving restlessness is vexed, quenches the thirst, profit Cardiopulmonary, mend five kinds of strain and seven kinds of impairment, deficient, and waist foot pain pain, sky row is fanatical." modern medicine study confirmation, Rhizoma Polygonati Odorati has of short duration blood pressure lowering with strong Heart effect, has obvious reduction effect to epinephrine induced hyperglycemia, can expand extremity vascular, alleviates atherosclerotic plaque The formation of block, improves Hemolysin level, strengthens the phagocytic function of macrophage, improves body's immunity.

Radix Gymnematis Sylvestris: bitter in the mouth；Property flat.GUIXIN；Liver；Spleen channel.Clearing away heat and cooling blood；Evacuation of pus is subsided a swelling；Pain relieving granulation promoting.Cure mainly rheumatism numbness Bitterly；Laryngopharynx swelling and pain；Scrofula；Acute mastitis；Furuncle；Eczema；Innominate toxic swelling；Venom." practical Chinese herbal medicine ": root, subduing swelling and detoxicating, clearly Hot removing heat from blood.Control multiple abscess, deep abscess, mastitis, ulcerative carbuncle toxic swelling.

Herba Artemisiae Scopariae: mildly bitter flavor；Micro-pungent；Cold nature.Enter spleen；Stomach；Bladder warp.Clearing away heat-damp and promoting diuresis；Jaundice eliminating.Cure mainly jaundice；Urine is not Profit；Eczema pruritus." Japan hanako materia medica " carries: " when controlling day row, disease, fanatical, headache head rotation, wind-eye pain, subtertian malaria, woman's lump in the abdomen, and Interior damage is weary absolutely." modern medicine study shows, Herba Artemisiae Scopariae can promote bile secretion and excretion, participate in bile acid, bilirubin, class ester and The metabolism of some poisonous substance, also has reduction blood fat, coronary artery dilating, promotion fibrinolytic, in addition with antipyretic, blood pressure lowering, antibacterial, antiinflammatory Deng effect.

Cortex Dictamni: bitter in the mouth；Salty；Cold.Return spleen；Lung；Small intestinal；Stomach；Bladder warp.Heat clearing and damp drying；Dispelling wind for relieving itching；Removing toxic substances.Cure mainly Rubella caused by wind heat noxious dampness；Eczema；Scabies；Jaundice；Damp and hot arthralgia pain." book on Chinese herbal medicine is original ": Cortex Dictamni, enters lung meridian, therefore can remove wind, Entering small intestine meridian, therefore can dry, husband's rheumatism was both removed, then vim and vigour from work, also go by heat.Control all mange, aversion to wind, scabies, Fructus Myricae rubrae, all Skin ulcer pyretic toxicity.

Bulbus Lilii: sweet in the mouth；Micro-hardship.Cold nature.Enter the heart；Lung meridian.Nourishing YIN and moistening the lung；Clearing away heart-fire for tranquillization.Cure mainly deficiency of YIN chronic cough；Apoplexy due to phlegm band Blood；The calentura later stage；Waste heat is the most clear；Or the unsuccessful caused fidgets due to deficiency palpitation with fear of feelings will；Insomnia and dreamful sleep；Absentminded；Carbuncle；Eczema." day China's son book on Chinese herbal medicine " carry: " feel at ease, determine gallbladder, benefit will, support the five internal organs.Control insane heresy crow position, mad cry, palpitation with fear, kill diseases due to noxious agents produced by various parasites gas, acute mastitis, carbuncle on the back And all skin ulcers swells, and the mad fortune of blood after managing property." modern medicine study shows, Bulbus Lilii have significantly eliminate the phlegm, antitussive effect, on kidney Gland cortex hormone function exhaustion has a significant protective effect, extends hypoxia endurance time, thin in addition with calmness, nourishing YIN and moistening the lung, suppression cancer Effect of born of the same parents' propagation.

Cortex sophorae: bitter in the mouth；Property flat.Return lung；The heart；Liver；Large intestine channel.Expelling wind and removing dampness；Expelling pus and promoting granulation；Subduing swelling and detoxicating.Cure mainly wind In outside evil；Orthotonus；Numbness of the skin；Calentura aphtha；Ulcerative gingivitis；Sore throat；Discharging fresh blood stool；Cellulitis；Hemorrhoid；Ulcer sores；Pudendum is wet Skin ulcer；Burn due to hot liquid or fire." not Lu ": main rotten skin ulcer.

Radix Puerariae: sweet in the mouth；Pungent；Property flat.Enter spleen；Stomach；Lung；Bladder warp.Expelling pathogenic factors from muscles for reducing heat；Deliver rash；Promoting the production of body fluid to quench thirst；Yang invigorating is only Rush down.Cure mainly fever caused by exogenous pathogens；Rigidity pain on the head and nape；Measles from the beginning of；Rash goes out the most smooth；Epidemic febrile disease is thirsty；Diabetes；Have loose bowels；Dysentery；Hypertension； Coronary heart disease." Bencao Jingshu " carries: " dismissing the key medicine of positive bright epidemic febrile disease pathogenic heat also, therefore master quenches one's thirst, high fever of the body, heat is stopped up septum pectorale and vomitted. Dissipating and rise, the property of wind medicine also, puts main all numbness." modern medicine study shows, Radix Puerariae can improve the oxygen metabolism of cardiac muscle, to cardiac muscle Metabolism produces beneficial effect, and makes telangiectasis, and blood viscosity reduces, and microcirculation improves, and can soften and protect blood vessel, having fall Blood pressure, blood sugar lowering, the effect of blood fat reducing, Radix Puerariae can strengthen the antibody Monoclonal ability of skin in addition, has the effect of maintenance skin.

Gentiana rhodantha Franch.: bitter in the mouth；Cold in nature.GUIXIN；Lung；Stomach；Large intestine channel.Clearing away heat-damp and promoting diuresis；Removing pathogenic heat from blood and toxic substance from the body.Cure mainly lung-heat cough with asthma； Consumptive disease is coughed expectorant blood；Jaundice；Dysentery；Have blood in stool；Dysuria；Lochiopyra；Infantile convulsion；Infantile malnutrition；Sore swollen toxin；Burn and scald；Venom. " Yunnan Chinese herbal medicine ": inflammation-diminishing and cough-controlling.Controlling pulmonary tuberculosis, lymphoid tuberculosis, bronchial asthma, excess-heat breathes with cough, dysuria, children's's infantile malnutrition Long-pending, acute catarrhal conjunctivitis, icterohepatitis.

The Rhizoma Anemarrhenae: bitter in the mouth；Cold in nature.Enter lung；Stomach；Kidney channel.Clearing away heat-fire；Nourshing Yin and drynsessmoistening prescription；Quench the thirst relieving restlessness.Cure mainly epidemic febrile disease；High Hot excessive thirst；Cough and asthma；Cough caused by dryness；Constipation；Osteopyrexia and fever；Restlessness of asrhenia type and insomnia；Quench one's thirst stranguria with turbid discharge." property of medicine opinion " carries: " cure mainly vexed hot-tempered Vexed, bone heat is strained, general debility during puerperium, kidney qi labor, and the loathing of cold is deficient, suffers from that people is empty and xerostomia, adds and use it." modern medicine study confirmation, The Rhizoma Anemarrhenae can suppress the liver catabolism to hydrocortisone, and multiple pathogenic microorganisms is had inhibitory action, in addition with reduce blood glucose, Suppression tumor growth and the effect of platelet aggregation.

Flos Campsis: sour in the mouth；Cold nature.Return Liver Channel.Clearing away heat and cooling blood；Blood stasis-eliminating and stagnation-dissipating；Dispelling wind for relieving itching.Amenorrhea due to stagnation of blood；Dysmenorrhea；? Abdominal mass；Metrorrhagia and metrostaxis；Heat in blood pruritus due to wind pathogen；Skin ulcer scabies falls into rash；Rosacea." Amplification on Materia Medica addendum ": Flos Campsis, controls in blood the key medicine of pain also, And nourishing YIN victory is very, is stamped and keeps and walk alone, in married woman side multiplex what.

Herba Ixeritis chinensis: bitter in the mouth；Cold in nature.Heat-clearing and toxic substances removing；Detumescence and apocenosis；Cooling blood for hemostasis.Cure mainly acute appendicitis；Lung abscess；Cough due to lung-heat； Enteritis；Dysentery disease；Cholecystitis；Pelvic inflammatory disease；Furuncle toxic swelling；Eczema scrotum；Spit blood；Epistaxis；Metrorrhagia；Traumatic injury." Shaanxi medium-height grass Medicine ": heat-clearing and toxic substances removing, purte the white, removing heat from blood, hemostasis, pain relieving, regulating menstruation, invigorate blood circulation, removing the necrotic tissue and promoting granulation.Control innominate toxic swelling, eczema scrotum, lung Inflammation, traumatic injury, fracture.

Herba Andrographis: bitter in the mouth；Cold in nature.GUIXIN；Lung；Large intestine；Bladder warp.Heat-clearing and toxic substances removing；Pathogenic fire purging；Dampness.Cure mainly anemopyretic cold； Epidemic febrile disease is generated heat；Cough due to lung-heat；Pertussis；Lung abscess；Laryngopharynx swelling and pain；Jaundice due to damp-heat；Stranguria；Erysipelas；Skin infection carbuncle；Eczema；Poisonous snake Bite." conventional Chinese herbal medicine color atlas ": heat clearing and inflammation relieving, antalgesic-antipruritic, antidotes against snake bite.Control parotitis, scorching in conjunction with film, epidemic encephalitis.

The present invention compared with prior art, has the advantages that

The present invention selects medical material monarch, minister, a left side, makes all reasons the most standby, and the property of medicine is suitable mutually auxiliary mutually, suits the remedy to the case for the cause of disease, has clear Diarrhea of heat type fire, removing pathogenic heat from blood and toxic substance from the body, dispelling wind for relieving itching, evacuation of pus detumescence, promoting tissue regeneration and ulcer healing, nourishing YIN and moistening the lung, effect of nourishing the stomach to promote the production of body fluid, assimilation effect Good, evident in efficacy, have no side effect and clinical adverse, higher to Perioral Dermatitis cure rate according to clinical verification.

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is further elaborated.

Embodiment 1

The raw material of effective ingredient of the present invention forms and weight is:

Caulis et Folium Brassicae campestris 65～80g, Semen phaseoli radiati powder 62～77g, the Radix Astragali 59～74g, little leaf of Broussonetia papyrifera (L.) L.Her.ex Vent. 56～71g,

Radix Sanguisorbae 53～68g, Radix Ophiopogonis 50～65g, Radix Scutellariae 46～62g, Herba portulacae 43～59g,

Radix Scrophulariae 40～56g, Fructus Lycii 37～53g, Radix Glycyrrhizae 34～50g, Fructus Ligustri Lucidi 31～47g,

Rhizoma Polygonati Odorati 28～43g, Radix Gymnematis Sylvestris 25～40g, Herba Artemisiae Scopariae 22～36g, Cortex Dictamni 19～33g,

Bulbus Lilii 16～30g, Cortex sophorae 13～27g, Radix Puerariae 10～23g, Gentiana rhodantha Franch. 8～20g,

The Rhizoma Anemarrhenae 6～18g, Flos Campsis 4～15g, Herba Ixeritis chinensis 2～12g, Herba Andrographis 1～9g.

The processing step of process for preparing medicine of the present invention is:

(1) by white to Caulis et Folium Brassicae campestris, Semen phaseoli radiati powder, little leaf of Broussonetia papyrifera (L.) L.Her.ex Vent., Radix Sanguisorbae, Radix Ophiopogonis, Herba portulacae, Radix Gymnematis Sylvestris, Herba Artemisiae Scopariae, Cortex Dictamni, Chinese scholartree Skin, Radix Puerariae, Flos Campsis, Herba Ixeritis chinensis Gentiana rhodantha Franch. are cleaned, are dried rear mix homogeneously, put in container, add 6～8 in a reservoir The water of times amount, heated and boiled 2～3 hours, take immersion after cooling；The water of 4～6 times amount is added, heating in remaining medicinal residues Boil 1～2 hour, after cooling, take immersion；Merging twice gained immersion, heating, evaporation and concentration is relative density 1.15～1.25 Thick paste, standby；

(2) Radix Scrophulariae, Fructus Lycii, Rhizoma Polygonati Odorati are put in container, add the shao-hsing rice wine of 3～5 times amount, cool after boiling, continue Continuous immersion 3～5 hours, takes immersion；In remaining medicinal residues, add the shao-hsing rice wine of 2～4 times amount, put after boiling and dry in the air, continue Soak 2～4 hours, take immersion；Merge twice gained immersion, add and steam the thick paste that evaporation and concentration is relative density 1.10～1.20, Standby；

(3) astragalus mongholicus tablet is added cooked Mel and a little boiled water, mixes thoroughly the most vexed, fry in putting pot to yellow and tack-free time, Taking-up is dried in the air cool, and pulverizing is ground into powder, crosses 100 mesh dusting covers, obtains fine powder, standby；

(4) take scutellaria tablet to mix thoroughly with a certain amount of yellow wine, slightly moistening, after yellow wine is sucked, put in parch container, with literary composition Fire fried dry, taking-up cools, and pulverizing is ground into powder, crosses 100 mesh dusting covers, obtains fine powder, standby；

(5) take clean Radix Glycyrrhizae tabellae, add cooked Mel and a little boiled water, the most vexed after mixing thoroughly, to put in parch container, slow fire is fried To buff, taking out, cool time tack-free, pulverizing is ground into powder, crosses 100 mesh dusting covers, obtains fine powder, standby；

(6) take clean Fructus Ligustri Lucidi to add yellow wine and mix thoroughly, put in appropriate vessel, airtight, to sit in kettle, stewing out of water to wine exhausts, and takes Go out, dry, pulverize and grind into powder, cross 100 mesh dusting covers, obtain fine powder, standby；

(7) take clean Bulbus Lilii, when frying to color burn with slow fire, add the refined honey diluted with a little boiled water, stir rapidly, Stirring uniformly, continuation slow fire is fried to time slightly yellow, tack-free, and taking-up cools, and pulverizing is ground into powder, crosses 100 mesh dusting covers, obtains fine powder, Standby；

(8) taking Rhizoma Anemarrhenae sheet to put in pot with the micro-stir-fry of slow fire, spray saline, take out and cool after fried dry, pulverizing is ground into powder, crosses 100 mesh Dusting cover, obtains fine powder, standby；

(9) by after clean for Herba Andrographis drying, pulverizing is ground into powder, crosses 100 mesh dusting covers, obtains fine powder, standby；

(10) by step (1), the thick paste of step (2) gained, with step (3), step (4), step (5), step (6), step Suddenly the fine powder mixing of gained in (7), step (8), step (9), adds adjuvant sucrose and dextrin mix homogeneously makes granule, be dried, After granulate, it is packaged into the instant particles as Chinese medicine of every bag of 12g.

Usage and dosage: oral, each 1 bag, every day 2 times, sub-service sooner or later, take after mixing it with water with boiled water half an hour ante cibum, within 7 days, be 1 The course for the treatment of.

Embodiment 2

The raw material of effective ingredient of the present invention forms and weight is:

Caulis et Folium Brassicae campestris 68～77g, Semen phaseoli radiati powder 65～74g, the Radix Astragali 62～71g, little leaf of Broussonetia papyrifera (L.) L.Her.ex Vent. 59～68g,

Radix Sanguisorbae 56～65g, Radix Ophiopogonis 53～62g, Radix Scutellariae 49～59g, Herba portulacae 46～56g,

Radix Scrophulariae 43～53g, Fructus Lycii 40～50g, Radix Glycyrrhizae 37～47g, Fructus Ligustri Lucidi 34～44g,

Rhizoma Polygonati Odorati 31～40g, Radix Gymnematis Sylvestris 28～37g, Herba Artemisiae Scopariae 25～33g, Cortex Dictamni 22～30g,

Bulbus Lilii 19～27g, Cortex sophorae 16～24g, Radix Puerariae 13～20g, Gentiana rhodantha Franch. 11～17g,

The Rhizoma Anemarrhenae 8～15g, Flos Campsis 6～12g, Herba Ixeritis chinensis 4～10g, Herba Andrographis 3～7g.

The process for preparing medicine processing step of the present embodiment and usage and dosage are same as in Example 1.

Embodiment 3

The raw material of effective ingredient of the present invention forms and weight is:

Caulis et Folium Brassicae campestris 74g, Semen phaseoli radiati powder 70g, Radix Astragali 67g, little leaf of Broussonetia papyrifera (L.) L.Her.ex Vent. 64g,

Radix Sanguisorbae 61g, Radix Ophiopogonis 58g, Radix Scutellariae 54g, Herba portulacae 51g,

Radix Scrophulariae 48g, Fructus Lycii 45g, Radix Glycyrrhizae 42g, Fructus Ligustri Lucidi 39g,

Rhizoma Polygonati Odorati 36g, Radix Gymnematis Sylvestris 32g, Herba Artemisiae Scopariae 29g, Cortex Dictamni 26g,

Bulbus Lilii 23g, Cortex sophorae 20g, Radix Puerariae 17g, Gentiana rhodantha Franch. 14g,

Rhizoma Anemarrhenae 11g, Flos Campsis 9g, Herba Ixeritis chinensis 6g, Herba Andrographis 4g.

The process for preparing medicine processing step of the present embodiment and usage and dosage are same as in Example 1.

Clinical data:

1, case selection

Selecting the Perioral Dermatitis patient 80 example clinical observation that my institute makes a definite diagnosis, patient is randomly divided into two groups.Treatment group 40 example, its Middle male 11 example, women 29 example, age 21～39 years old, 29.6 years old mean age.Matched group 40 example, wherein male 9 example, women 31 Example, age 22～38 years old, 29.2 years old mean age.Two groups of qualifications and record of service are basically identical, without significant difference, have comparability.

2, treatment group patient takes medicine of the present invention, oral, each 1 bag, every day 2 times, sub-service sooner or later, half an hour ante cibum with Boiled water is taken after mixing it with water, and within 7 days, is 1 course for the treatment of, takes 6 courses for the treatment of.Matched group patient gives tetracycline and takes orally, 0.25g/ time, 2～4 times/d, If being in a bad way, 0.25g/ time, 4 times/d, take six weeks.

In therapeutic process, two groups of patients all stop using toothpaste with fluoride and fluorine-containing corticosteroid hormone.

3, efficacy determination:

3.1 observation index

Carry out conscious burning sensation before treatment and after treatment to mark with scratchiness, and to pimple, pustule, erythema, squama The nbjective symptoms such as bits are marked, according to without, light, in, weight be calculated as 0 point, 1 point, 2 points, 3 points successively, treatment terminate after according to skin Damage integration decline percentage ratio and evaluate two groups of clinical efficacies.

3.2 efficacy assessment standard

Recovery from illness: skin lesion integration declines ＞ 95%, without new breakout；

Effective: skin lesion integration declines 20%～94%, without new breakout；

Invalid: skin lesion integration declines ＜ 20%, constantly has new erythra to occur.

Effective percentage=[(recovery from illness+effective)/total number of cases] × 100%.

4, result

4.1 treatment group cure rates 85%, total effective rate 95%, matched group cure rate 72.5%, total effective rate 87.5%, two Group comparitive study, difference has a statistical significance (P < 0.05), therefore treatment group is substantially better than matched group for the curative effect of primary disease.

1 liang of table group patient clinical comparitive study

4.2 treatments are checked after terminating 3 months, and treatment group patient has 2 example recurrences, and relapse rate 5%, matched group patient has 11 examples Recurrence, relapse rate 27.5%, therefore treatment group patient's curative effect is significantly better than matched group.

Model case is illustrated:

1, neat ××, female, 33 years old, office worker.There is lamellar erythema in this patient's lip surrounding skin, is dried discomfort, often feels Feel is itched, and buys erythromycin ointment external application to pharmacy, but symptom does not take a favorable turn, later institute's inquiring, is diagnosed as Perioral Dermatitis, first warp After taking 3 courses for the treatment of of Chinese medicine of the present invention, around lip, erythema turns light, and gargalesthesia disappears, and follows the doctor's advice and continues to take institute of the present invention After stating 2 courses for the treatment of of Chinese medicine, above-mentioned symptom is wholly absent, follow up a case by regular visits to 3 months without recurrence, fully recover.

2, what ××, female, 27 years old, workman.This patient's bicker has played some pimples, feels to itch, bid in Pevisone paste External application, but do not take a favorable turn, pimple becomes many, huge itch hard to bear, institute's inquiring later, be diagnosed as Perioral Dermatitis, first through taking the present invention After 6 courses for the treatment of of described Chinese medicine, above-mentioned symptom is wholly absent, follow up a case by regular visits to 3 months without recurrence, fully recover.

Perioral Dermatitis is department of dermatologry common disease, and its pathogenesis is still not clear, may with diet, environment, contact allergy, Toothpaste or fluorine-containing 17-hydroxy-11-dehydrocorticosterone that endocrine alteration, cosmetics, use are fluorine-containing are relevant, and daylight factor can make exacerbation of symptoms, but Concrete cause of disease medical circle not final conclusion.Doctor trained in Western medicine uses Drug therapy, though the clinical symptoms of energy respite patient, the most multiple Send out.Perioral Dermatitis is attributed to the categories such as " skin ulcer rash ", " herpes simplex ", " exfoliative inflammation of the lips ", " lip cocoon " in the traditional Chinese medical science, sick position at lung stomach, many because of The evil invasion and attack of burning hot poison, in long underlying mass, cause damp and hot interior life, and lung loses in evacuation, and taste are stranded by damp and hot, two heresies are fought mutually, leap up under upper steaming, Exuberant skin and send out in lip, and show, swell, itch, the disease such as skin ulcer rash, therefore this disease sees table and in disease arises from, concerns lung stomach, Therefore the present invention suits the remedy to the case according to the cause of disease, side in Radix Scutellariae, the Rhizoma Anemarrhenae, Herba Andrographis can clearing away heat-fire；Semen phaseoli radiati powder in side, Caulis et Folium Brassicae campestris, Radix Scrophulariae, Radix Sanguisorbae, Herba portulacae can removing pathogenic heat from blood and toxic substance from the body；Cortex Dictamni, Flos Campsis in side, little leaf of Broussonetia papyrifera (L.) L.Her.ex Vent. can dispelling wind for relieving itching；In side, Radix Puerariae can move back by expelling pathogenic factors from muscles Heat, deliver rash；Radix Gymnematis Sylvestris in side, Cortex sophorae, Herba Ixeritis chinensis can clearing away heat and cooling blood, evacuation of pus detumescence；In side the Radix Astragali can invigorating QI to consolidate the body surface resistance, hold back Skin ulcer granulation promoting；Radix Gentianae in side, Herba Artemisiae Scopariae can clearing away heat-damp and promoting diuresis；Fructus Ligustri Lucidi in side, Fructus Lycii can tonifying liver kidney yin；Radix Ophiopogonis in side, Rhizoma Polygonati Odorati, Bulbus Lilii can nourishing YIN and moistening the lung, nourishing the stomach to promote the production of body fluid；In side, Radix Glycyrrhizae can coordinating the actions of various ingredients in a prescription；In side, all medicines share and can play clearing away heat-fire, removing heat from blood solution altogether Poison, dispelling wind for relieving itching, evacuation of pus detumescence, expelling pus and promoting granulation, nourishing YIN and moistening the lung, effect of nourishing the stomach to promote the production of body fluid, heat clearing away not impairment of YIN, YIN nourishing do not help heat, Good absorbing effect, evident in efficacy, have no side effect and clinical adverse, higher to Perioral Dermatitis cure rate according to clinical verification.

Claims (4)

1. the instant particles as Chinese medicine being used for treating Perioral Dermatitis, it is characterised in that: make the raw material group of described effective ingredient Become and parts by weight be:

Caulis et Folium Brassicae campestris 65～80 parts, Semen phaseoli radiati powder 62～77 parts, the Radix Astragali 59～74 parts, little leaf of Broussonetia papyrifera (L.) L.Her.ex Vent. 56～71 parts, Radix Sanguisorbae 53～68 parts, wheat Door the winter 50～65 parts, Radix Scutellariae 46～62 parts, Herba portulacae 43～59 parts, Radix Scrophulariae 40～56 parts, Fructus Lycii 37～53 parts, Radix Glycyrrhizae 34～ 50 parts, Fructus Ligustri Lucidi 31～47 parts, Rhizoma Polygonati Odorati 28～43 parts, Radix Gymnematis Sylvestris 25～40 parts, Herba Artemisiae Scopariae 22～36 parts, Cortex Dictamni 19～33 parts, Bulbus Lilii 16～30 parts, Cortex sophorae 13～27 parts, Radix Puerariae 10～23 parts, Gentiana rhodantha Franch. 8～20 parts, the Rhizoma Anemarrhenae 6～18 parts, Flos Campsis 4 ～15 parts, Herba Ixeritis chinensis 2～12 parts, Herba Andrographis 1～9 parts.

A kind of instant particles as Chinese medicine for treating Perioral Dermatitis the most according to claim 1, it is characterised in that: make described medicine The raw material of thing effective ingredient forms and parts by weight are:

Caulis et Folium Brassicae campestris 68～77 parts, Semen phaseoli radiati powder 65～74 parts, the Radix Astragali 62～71 parts, little leaf of Broussonetia papyrifera (L.) L.Her.ex Vent. 59～68 parts, Radix Sanguisorbae 56～65 parts, wheat Door the winter 53～62 parts, Radix Scutellariae 49～59 parts, Herba portulacae 46～56 parts, Radix Scrophulariae 43～53 parts, Fructus Lycii 40～50 parts, Radix Glycyrrhizae 37～ 47 parts, Fructus Ligustri Lucidi 34～44 parts, Rhizoma Polygonati Odorati 31～40 parts, Radix Gymnematis Sylvestris 28～37 parts, Herba Artemisiae Scopariae 25～33 parts, Cortex Dictamni 22～30 parts, Bulbus Lilii 19～27 parts, Cortex sophorae 16～24 parts, Radix Puerariae 13～20 parts, Gentiana rhodantha Franch. 11～17 parts, the Rhizoma Anemarrhenae 8～15 parts, Flos Campsis 6 ～12 parts, Herba Ixeritis chinensis 4～10 parts, Herba Andrographis 3～7 parts.

A kind of instant particles as Chinese medicine for treating Perioral Dermatitis the most according to claim 1, it is characterised in that: make described medicine The raw material of thing effective ingredient forms and parts by weight are:

Caulis et Folium Brassicae campestris 74 parts, Semen phaseoli radiati powder 70 parts, the Radix Astragali 67 parts, little leaf of Broussonetia papyrifera (L.) L.Her.ex Vent. 64 parts, Radix Sanguisorbae 61 parts, Radix Ophiopogonis 58 parts, Radix Scutellariae 54 parts, horse Tooth bamboo water pipe 51 parts, Radix Scrophulariae 48 parts, Fructus Lycii 45 parts, 42 parts of Radix Glycyrrhizae, Fructus Ligustri Lucidi 39 parts, Rhizoma Polygonati Odorati 36 parts, Radix Gymnematis Sylvestris 32 parts, Herba Artemisiae Scopariae 29 Part, Cortex Dictamni 26 parts, Bulbus Lilii 23 parts, Cortex sophorae 20 parts, Radix Puerariae 17 parts, Gentiana rhodantha Franch. 14 parts, the Rhizoma Anemarrhenae 11 parts, Flos Campsis 9 parts, mountain Gutweed 6 parts, Herba Andrographis 4 parts.

The preparation method of a kind of instant particles as Chinese medicine for treating Perioral Dermatitis the most according to claims 1 to 3, its feature exists In: comprise the following steps that:

(1) by Caulis et Folium Brassicae campestris, Semen phaseoli radiati powder, little leaf of Broussonetia papyrifera (L.) L.Her.ex Vent., Radix Sanguisorbae, Radix Ophiopogonis, Herba portulacae, Radix Gymnematis Sylvestris, Herba Artemisiae Scopariae, Cortex Dictamni, Cortex sophorae, Pueraria lobota Root, Flos Campsis, Herba Ixeritis chinensis Gentiana rhodantha Franch. are cleaned, are dried rear mix homogeneously, put in container, add 6～8 times amount in a reservoir Water, heated and boiled 2～3 hours, take immersion after cooling；In remaining medicinal residues, add the water of 4～6 times amount, heated and boiled 1～ 2 hours, after cooling, take immersion；Merge twice gained immersion, heating, evaporation and concentration is the thick paste of relative density 1.15～1.25, Standby；

(2) Radix Scrophulariae, Fructus Lycii, Rhizoma Polygonati Odorati are put in container, add the shao-hsing rice wine of 3～5 times amount, cool after boiling, continue leaching Steep 3～5 hours, take immersion；In remaining medicinal residues, add the shao-hsing rice wine of 2～4 times amount, put after boiling and dry in the air, continue immersion 2 ～4 hours, take immersion；Merge twice gained immersion, add and steam the thick paste that evaporation and concentration is relative density 1.10～1.20, standby；

(3) astragalus mongholicus tablet is added cooked Mel and a little boiled water, mixes thoroughly the most vexed, fry in putting pot to yellow and tack-free time, take out Drying in the air cool, pulverizing is ground into powder, crosses 100 mesh dusting covers, obtains fine powder, standby；

(4) take scutellaria tablet to mix thoroughly with a certain amount of yellow wine, slightly moistening, after yellow wine is sucked, puts in parch container, fry with slow fire Dry, taking-up cools, and pulverizing is ground into powder, crosses 100 mesh dusting covers, obtains fine powder, standby；

(5) take clean Radix Glycyrrhizae tabellae, add cooked Mel and a little boiled water, the most vexed after mixing thoroughly, to put in parch container, slow fire is fried to deeply Yellow, takes out time tack-free, cools, and pulverizing is ground into powder, crosses 100 mesh dusting covers, obtains fine powder, standby；

(6) take clean Fructus Ligustri Lucidi to add yellow wine and mix thoroughly, put in appropriate vessel, airtight, to sit in kettle, stewing out of water to wine exhausts, and takes out, dry Dry, pulverizing is ground into powder, crosses 100 mesh dusting covers, obtains fine powder, standby；

(7) take clean Bulbus Lilii, when frying to color burn with slow fire, add the refined honey diluted with a little boiled water, stir rapidly, stir Uniformly, continuation slow fire is fried to time slightly yellow, tack-free, and taking-up cools, and pulverizing is ground into powder, crosses 100 mesh dusting covers, obtains fine powder, standby；

(8) taking Rhizoma Anemarrhenae sheet to put in pot with the micro-stir-fry of slow fire, spray saline, take out and cool after fried dry, pulverizing is ground into powder, crosses 100 mesh dusting covers, Obtain fine powder, standby；

(9) by after clean for Herba Andrographis drying, pulverizing is ground into powder, crosses 100 mesh dusting covers, obtains fine powder, standby；

(10) by step (1), the thick paste of step (2) gained, with step (3), step (4), step (5), step (6), step (7), the fine powder mixing of gained in step (8), step (9), add adjuvant sucrose and dextrin mix homogeneously make granule, be dried, whole After Li, it is packaged into the instant particles as Chinese medicine of every bag of 12g.