CN103784803B - A kind of medicine and preparation method for the treatment of chronic pharyngitis - Google Patents
A kind of medicine and preparation method for the treatment of chronic pharyngitis Download PDFInfo
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Abstract
The invention discloses a kind of medicine and preparation method for the treatment of chronic pharyngitis, belong to the field of Chinese medicines; The raw material of effective ingredient of the present invention consists of: Rhizoma Nelumbinis, Radix Tinosporae, Fructus Momordicae, Fructus Ligustri Lucidi, Caulis Bambusae In Taenia, Semen Armeniacae Amarum, Radix Cudraniae, Periostracum Cicadae, Radix Platycodonis, arrowhead, Herba Rostellulariae, Herba Sonchi Oleracei, Herba Houttuyniae, Venenum Bufonis, Flos Lonicerae and Herba Cichorii; Chinese medicine preparation of the present invention selects high-quality Chinese crude drug scientific compatibility to make, there is effect of promoting blood circulation to remove obstruction in the collateral, tonifying YIN eliminating stagnation, relieving sore throat and pain, can alleviate and thoroughly eradicate pharyngodynia with dryness, foreign body sensation that chronic pharyngitis causes, the clinical symptoms such as scorching hot of itching, evident in efficacy, safe without toxic side effect, treatment total effective rate is up to 97.4%.
Description
Art
The present invention relates to the field of Chinese medicines, particularly relate to a kind of medicine and preparation method for the treatment of chronic pharyngitis.
Background technology
Chronic pharyngitis many because of acute pharyngitis recurrent exerbation or treatment thorough, and adjacent organs focus stimulates such as sinusitis, tonsillitis, nasopharyngitis, tracheitis etc. cause.Tobacco and wine excessively, dust and harmful gas stimulate for commonly encountered diseases because of.
Chronic pharyngitis pathological changes, mainly at mucous layer, shows as pharyngeal mucosa chronic congestion, has infiltration of more lymphocytes around its blood vessel, also show leukocyte and plasmocyte infiltrating, connective tissue proliferation under mucosa and mucosa, mucous gland can be loose, secretory function is hyperfunction, and mucilage secretion increases.Be more common in adult, the course of disease is long, easily recurs.
Chronic pharyngitis General Symptoms is all not obvious, and based on local symptom.Various chronic pharyngitis symptom is roughly similar, and varied, as pharyngeal sense of discomfort, foreign body sensation, gargalesthesia, burning sensation, dry sensation or excitement, and also can by hypodynia etc.Caused by stimulating primarily of the lymph follicle of its secretions and hypertrophy; In addition, also can have cough, feel sick etc. symptom.
Chronic pharyngitis causes cough, breathes heavily and suppress, the pathological change caused, and then causes the respiratory tract disease of appearance a lot.Bottleneck throat swelling can affect swallowing of food.The inflammation of bottleneck throat or other pathological changes stimulate esophagus dominating neural, cause diaphragm spasm, there will be the symptom such as singultus, epigastric oppression.
For the treatment of chronic pharyngitis, being mainly manifested in and eliminating various paathogenic factor, as given up tobacco and wine, improving working environment, active treatment nose and nasopharynx chronic inflammatory focus and relevant systemic disease.Meanwhile, carry out topical therapeutic, topical therapeutic commonly uses Dobell's solution, furacilin solution, 2% borate rinsing the mouth, with keep oral cavity, oropharynx clean, or buccal lozenge, in addition, also available glycerinum iodi compositum, 13% silver nitrate solution or 10% argyrol solution are smeared pharyngeal.
Above-mentioned Therapeutic Method has certain curative effect in treatment chronic pharyngitis, but therapeutic effect is not thorough, and easy recurrent exerbation, makes patient enjoy disease to torment.
Summary of the invention
The invention provides a kind of medicine and preparation method for the treatment of chronic pharyngitis; Chinese medicine preparation of the present invention selects high-quality Chinese crude drug scientific compatibility to make, there is effect of promoting blood circulation to remove obstruction in the collateral, tonifying YIN eliminating stagnation, relieving sore throat and pain, can alleviate and thoroughly eradicate pharyngodynia with dryness, foreign body sensation that chronic pharyngitis causes, the clinical symptoms such as scorching hot of itching, evident in efficacy, safe without toxic side effect, treatment total effective rate is up to 97.4%.
For achieving the above object, technical scheme of the present invention is implemented as follows:
Treat a medicine for chronic pharyngitis, raw material composition and the parts by weight of making described effective ingredient are:
Rhizoma Nelumbinis 42 ~ 68 portions of Radix Tinosporaes 35 ~ 65 portions of Fructus Momordicaes 34 ~ 58 parts of Fructus Ligustri Lucidi 32 ~ 57 parts
Caulis Bambusae In Taenia 28 ~ 58 parts of Semen Armeniacae Amarums 27 ~ 57 parts of Radix Cudraniaes 23 ~ 53 portions of Periostracum Cicadaes 26 ~ 51 parts
Radix Platycodonis 23 ~ 48 parts of arrowheads 21 ~ 47 parts of Herba Rostellulariaes 19 ~ 43 parts of Herba Sonchi Oleracei 18 ~ 42 parts
Herba Houttuyniae 15 ~ 40 parts of Venenum Bufoniss 16 ~ 40 portions of Flos Loniceraes 16 ~ 34 portions of Herba Cichoriis 12 ~ 30 parts.
Raw material composition and the parts by weight of making described effective ingredient are:
Rhizoma Nelumbinis 46 ~ 64 portions of Radix Tinosporaes 40 ~ 60 portions of Fructus Momordicaes 38 ~ 54 parts of Fructus Ligustri Lucidi 36 ~ 53 parts
Caulis Bambusae In Taenia 33 ~ 53 parts of Semen Armeniacae Amarums 32 ~ 52 parts of Radix Cudraniaes 28 ~ 48 portions of Periostracum Cicadaes 30 ~ 47 parts
Radix Platycodonis 28 ~ 44 parts of arrowheads 26 ~ 42 parts of Herba Rostellulariaes 23 ~ 39 parts of Herba Sonchi Oleracei 22 ~ 38 parts
Herba Houttuyniae 19 ~ 36 parts of Venenum Bufoniss 20 ~ 36 portions of Flos Loniceraes 19 ~ 31 portions of Herba Cichoriis 15 ~ 27 parts.
Raw material composition and the parts by weight of making described effective ingredient are:
Rhizoma Nelumbinis 51 ~ 59 portions of Radix Tinosporaes 45 ~ 55 portions of Fructus Momordicaes 42 ~ 50 parts of Fructus Ligustri Lucidi 41 ~ 49 parts
Caulis Bambusae In Taenia 38 ~ 48 parts of Semen Armeniacae Amarums 37 ~ 47 parts of Radix Cudraniaes 33 ~ 43 portions of Periostracum Cicadaes 34 ~ 42 parts
Radix Platycodonis 34 ~ 40 parts of arrowheads 30 ~ 38 parts of Herba Rostellulariaes 27 ~ 35 parts of Herba Sonchi Oleracei 26 ~ 34 parts
Herba Houttuyniae 23 ~ 32 parts of Venenum Bufoniss 24 ~ 32 portions of Flos Loniceraes 22 ~ 28 portions of Herba Cichoriis 18 ~ 24 parts.
Raw material composition and the parts by weight of making described effective ingredient are:
Rhizoma Nelumbinis 55 portions of Radix Tinosporaes 50 portions of Fructus Momordicaes 46 parts of Fructus Ligustri Lucidi 45 parts
Caulis Bambusae In Taenia 43 parts of Semen Armeniacae Amarums 42 parts of Radix Cudraniaes 38 portions of Periostracum Cicadaes 38 parts
Radix Platycodonis 36 parts of arrowheads 34 parts of Herba Rostellulariaes 31 parts of Herba Sonchi Oleracei 30 parts
Herba Houttuyniae 28 parts of Venenum Bufoniss 28 portions of Flos Loniceraes 25 portions of Herba Cichoriis 21 parts.
Treat a preparation method for the medicine of chronic pharyngitis, comprise following processing step:
(1) Rhizoma Nelumbinis and Herba Sonchi Oleracei are cleaned, shady and cool place dries, and chopping, puts into container, strand juice, and filter impurity, stays juice for subsequent use;
(2) Radix Tinosporae, Semen Armeniacae Amarum, Periostracum Cicadae and Herba Houttuyniae are mixed, carry out pulverization process after mix homogeneously, grind into powder, cross 160 order fine powders, for subsequent use;
(3) Fructus Momordicae, Fructus Ligustri Lucidi, Caulis Bambusae In Taenia, Radix Platycodonis, arrowhead and Herba Rostellulariae are cleaned, put into container, add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate, being condensed into relative density at 60 DEG C is the thick paste of 1.10 ~ 1.16, for subsequent use;
(3) Radix Cudraniae, Venenum Bufonis, Flos Lonicerae and Herba Cichorii are cleaned, immerse the alcohol solution dipping 3 ~ 4 hours of 85% of 8 times amount, heating and refluxing extraction 2 ~ 3 hours, reclaim ethanol, filter, by the thick paste of relative density 1.20 ~ 1.25 under filtrate simmer down to 80 DEG C of environment, for subsequent use;
(5) by juice, fine powder and the thick paste mixing obtained by above-mentioned steps (1) ~ (4), make tablet, obtain the medicine for the treatment of chronic pharyngitis of the present invention.
The property of medicine of the present invention's Chinese medicine used is as follows:
Rhizoma Nelumbinis: sweet in the mouth, puckery, property is put down; Return liver, lung, stomach warp.Be longer than hemostasis, holding concurrently can dissipating blood stasis.For epistaxis, hemoptysis, spit blood, have blood in stool, hematuria and woman uterine bleeding, person is the most suitable to have blood stasis to lose blood.
Radix Tinosporae: bitter in the mouth, cold in nature; Return lung, large intestine channel.Heat-clearing and toxic substances removing, relieving sore throat and pain.For laryngopharynx swelling and pain, carbuncle furunculosis, has loose bowels, dysentery, gastral cavity abdomen burning pain.Guangzhou army " conventional Chinese herbal medicine handbook " carries: " heat-clearing and toxic substances removing, relieving sore throat and pain.Control diphtheria, acute pharyngolaryngitis, tonsillitis, heat syndrome cough aphonia, bacillary dysentery, traumatic injury, snakebite.”
Fructus Momordicae: sweet in the mouth, cool in nature; Return lung, large intestine channel.Clearing heat and moistening lung, laxation relieving constipation, for lung-fire cough caused by dryness, pharyngalgia aphonia, dryness of the intestine constipation." Guangxi Chinese medicinal herbal " carries: " cough-relieving heat clearing away, removing heat from blood intestine moistening.Control cough, the dry gastric heat constipation of blood etc.”
Fructus Ligustri Lucidi: sweet in the mouth, hardship, property is put down; Return liver, kidney channel.Liver and kidney tonifying, clearind deficient heat, improving eyesight.There is enhancing immunologic function, raise peripheral leukocytes, strengthen reticuloendothelial system phagocytic activity, strengthen the effect of cellular immunization and humoral immunization; Have heart tonifying, diuresis and protect the liver, cough-relieving, cathartic, the effect such as antibacterial, anticancer.Clinic study shows, Fructus Ligustri Lucidi can significantly improve T lymphocyte function, and Fructus Ligustri Lucidi promotes the activity of T cell by the activity of enhancing cell surface receptor; Can strengthen cellular immune function, skin bubble method surveys macrophage phagocytic function and blood lymphocytes rosette is significantly increased.
Caulis Bambusae In Taenia: sweet in the mouth, is slightly cold; Enter lung, stomach, gallbladder meridian.Removing heat-phlegm, relieves restlessness and prevents vomiting.For phlegm-heat cough, expectorant held under the arm by gallbladder fire, and dysphoria with smothery sensation is vomitted, and eye is lost in palpitation with fear, middle wind-phlegm fan, aphasia with stiff tongue, gastropyretic vomiting, pregnancy reactions, frequent fetal movement." detailed outline " carries: " cure the wound cold recurrence caused by overexertion, little Re Epilepsy, married woman's fetal movement." in clinical practice, there are the effects such as clearing away phlegm dissipating depression of QI, clearing away heat to stop vomiting and clearing heat and relieving fidgetness.
Semen Armeniacae Amarum: bitter in the mouth, tepor, slightly poisonous.Relieving cough and asthma, loosening bowel to relieve constipation.The bitter warm lung qi dispersing of Semen Armeniacae Amarum, loosening bowel to relieve constipation can promote skin microcirculation, and institute's rich in vitamin E has the effect of prevention skin and hair follicle senilism." nourish one's nature and want paper money " carries: " control food Semen Armeniacae Amarum poisoning, lower profit is tired bitter, side with Fructus Armeniacae Mume juice solution it.Side takes it with the blue or green juice of indigo plant again." Semen Armeniacae Amarum rich in proteins, fat, saccharide, carotene, vitamin B group, vitamin C, Citrin and calcium, phosphorus, the nutritional labeling such as ferrum.Wherein the content of carotene is only second to Fructus Mangifera Indicae in fruit, and Semen Armeniacae Amarum is called anticancer fruit by people.Semen Armeniacae Amarum contains abundant fatty oil, has the effect reducing cholesterol, and therefore, Semen Armeniacae Amarum has good effect to control cardiovascular system diseases.
Radix Cudraniae: lightly seasoned, micro-hardship, cool in nature.Dispelling wind and removing obstruction in the collateral, removing damp-heat, removing toxic substances and promoting subsidence of swelling.Cure mainly rheumatic arthralgia, traumatic injury, yellow cellulitis, parotitis, pulmonary tuberculosis, gastric duodenal ulcer, stranguria with turbid discharge, distention of the abdomen caused by various parasites, amenorrhea, impairment caused by overstrain hemoptysis, treat carbuncle sore and swell.Modern medicine study confirms, Radix Cudraniae root ethanol extraction has good anti-tubercle bacillus effect.
Periostracum Cicadae: sweet in the mouth, cold in nature; Return lung, Liver Channel.Loose wind heat extraction, sore-throat relieving rash, nebula removing spasmolytic.For anemopyretic cold, pharyngalgia, hoarseness, measles without adequate eruption, rubella pruritus, cataract, convulsion with spasms, tetanus." detailed outline " carries: " control phlegm-accumulating vertigo, skin wind heat, varioliform exanthema is had an itch, tetanus and treatment toxic swelling skin ulcer, and adult's aphonia, children's's lockjaw sky hangs, frightened night cry of crying, swelling of the vulva.”
Radix Platycodonis: bitter in the mouth, pungent, property is put down; Return lung meridian.Lung qi dispersing sore-throat relieving, evacuation of pus of eliminating the phlegm.For cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus." Li Gao " carries: " sharp chest and diaphragm, (controlling) throat gas is stopped up and pain, broken stagnant gas and long-pending block, (removing) pulmonary wind heat, the clear sharp head, sharp key.”
Arrowhead: sweet in the mouth, property are flat.Promoting the production of body fluid for nourishing the lung, invigorating the spleen and replenishing QI, has unique curative effect to the disease such as impairment caused by overstrain, cough with asthma.Analysis shows, arrowhead Main Ingredients and Appearance is starch, protein and multivitamin, is rich in the trace element needed for various active thing such as ferrum, zinc, boron, can has adjustment facilitation to human body flesh.Modern nutriology thinks that arrowhead is rich in vitamin and mineral potassium, calcium and dietary fiber, and protein is also more, can prevent anemia and edema etc., also can appetite stimulator.The traditional Chinese medical science think it have invigorate blood circulation, relieving constipation, clearing heat for detumescence work.
Herba Rostellulariae: salty in the mouth, cold in nature; Return lung, liver, kidney channel.Heat-clearing and toxic substances removing, inducing diuresis to remove edema, invigorates blood circulation.Modern doctor's research confirms, Herba Rostellulariae medicinal liquid has stronger inhibitory action to staphylococcus aureus, congratulates, this is close, Fu Shi, bacterium sonnei also have certain inhibitory action to will.Herba Rostellulariae: mildly bitter flavor, cold in nature.Heat-clearing and toxic substances removing, inducing diuresis to remove edema, preventing the attack (or recurrence) of malaria.For cold, fever, malaria, laryngopharynx swelling and pain, infantile malnutrition, dysentery, enteritis, oedema due to nephritis, urinary system infection, chyluria, external is controlled carbuncle furuncle and is swollen, traumatic injury.Guangzhou army " conventional Chinese herbal medicine handbook " carries: " heat-clearing and toxic substances removing, disappear stagnant dissipating blood stasis.Cure cold fever, laryngopharynx swelling and pain, infantile malnutrition, acute mastitis, hepatitis, traumatic injury.”
Herba Sonchi Oleracei: bitter in the mouth, cold in nature; Enter the heart, spleen, stomach three warp.Heat-clearing and toxic substances removing, removing blood stasis with potent drugs is invigorated blood circulation, evacuation of pus.For appendicitis, peritoneal abscess, enteritis, dysentery, acute and chronic pelvic inflammatory disease, cough due to lung-heat, pulmonary tuberculosis, spits blood, epistaxis; Traumatic injury is controlled in external, and furuncle swells and ache, impetigo, eczema scrotum.
Herba Houttuyniae: acrid in the mouth, cold nature; Enter lung meridian.Heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, inducing diuresis for treating stranguria syndrome.Be usually used in the diseases such as treatment lung abscess, cough due to lung-heat, sore swollen toxin.Modern pharmacological research shows, the Multiple components such as the volatile oil contained in Herba Houttuyniae, houttuynine sodium bisulfite, stronger inhibitory action is had to the various pathogens such as staphylococcus aureus, Diplococcus pneumoniae and influenza virus, leptospira etc., the phagocytic activity of leukocyte and macrophage can be strengthened, improve body immunity.In addition, the effect of radiation resistance and enhancing human body immunity function is also had, and without any side effects.
Venenum Bufonis: sweet in the mouth, pungent, warm in nature, poisonous.Refreshing and detoxicating, anti-inflammatory analgetic.For scarlet fever, laryngopharynx swelling and pain.Acute throat trouble retropharyngeal abscess, single bilateral tonsillitis, children's's furuncle, carbuncle and ulcer furuncle are treated, acute mastitis carbuncle on the back, innominate toxic swelling." book on Chinese herbal medicine converges and says " carries: " Venenum Bufonis, current twelve channels and collaterals, Zang Fu, film are former, trench, joint Zhu Chu.Venenum Bufonis, treat infantile malnutrition, disappear tympanites, separates the medicine of furunculosis also.”
Flos Lonicerae: sweet in the mouth, micro-hardship, cold in nature; Return lung, stomach, the heart, large intestine channel.Heat clearing away is eliminating evil, dispelling wind-heat, removing summer-heat blood poison.Modern pharmacological research shows, effective ingredient in Flos Lonicerae has antibacterial and antivirus action, obvious inhibitory action is had to staphylococcus aureus, Hemolytic streptococcus, dysentery bacterium, Bacillus typhi, meningococcus, Diplococcus pneumoniae, bacillus pyocyaneus and influenza virus etc., and can immunologic function be strengthened, antiinflammatory, antipyretic, there is obvious inhibitory action to inflammation.
Herba Cichorii: bitter in the mouth, salty, cold in nature.Liver heat removing function of gallbladder promoting, invigorating the stomach and promoting digestion, heat-clearing and toxic substances removing, inducing diuresis to remove edema.Cure mainly jaundice due to damp-heat, oedema due to nephritis, epigastric distending pain, inappetence, for jaundice due to damp-heat, stomachache lack of appetite, edema oliguria.Pharmacological evaluation shows, the ethanol of root of Herba Cichorii or ether extract have antibacterial, astriction.
The present invention compared with prior art, has following beneficial effect:
Chinese medicine preparation of the present invention selects high-quality Chinese crude drug scientific compatibility to make, there is effect of promoting blood circulation to remove obstruction in the collateral, tonifying YIN eliminating stagnation, relieving sore throat and pain, can alleviate and thoroughly eradicate pharyngodynia with dryness, foreign body sensation that chronic pharyngitis causes, the clinical symptoms such as scorching hot of itching, evident in efficacy, safe without toxic side effect, treatment total effective rate is up to 97.4%.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
The raw material composition of effective ingredient of the present invention and weight are:
Rhizoma Nelumbinis 64g Radix Tinosporae 60g Fructus Momordicae 54g Fructus Ligustri Lucidi 53g
Caulis Bambusae In Taenia 53g Semen Armeniacae Amarum 52g Radix Cudraniae 48g Periostracum Cicadae 47g
Radix Platycodonis 44g arrowhead 42g Herba Rostellulariae 39g Herba Sonchi Oleracei 38g
Herba Houttuyniae 36g Venenum Bufonis 36g Flos Lonicerae 31g Herba Cichorii 27g.
The preparation method of medicine of the present invention, comprises following processing step:
(1) Rhizoma Nelumbinis and Herba Sonchi Oleracei are cleaned, shady and cool place dries, and chopping, puts into container, strand juice, and filter impurity, stays juice for subsequent use;
(2) Radix Tinosporae, Semen Armeniacae Amarum, Periostracum Cicadae and Herba Houttuyniae are mixed, carry out pulverization process after mix homogeneously, grind into powder, cross 160 order fine powders, for subsequent use;
(3) Fructus Momordicae, Fructus Ligustri Lucidi, Caulis Bambusae In Taenia, Radix Platycodonis, arrowhead and Herba Rostellulariae are cleaned, put into container, add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate, being condensed into relative density at 60 DEG C is the thick paste of 1.10 ~ 1.16, for subsequent use;
(3) Radix Cudraniae, Venenum Bufonis, Flos Lonicerae and Herba Cichorii are cleaned, immerse the alcohol solution dipping 3 ~ 4 hours of 85% of 8 times amount, heating and refluxing extraction 2 ~ 3 hours, reclaim ethanol, filter, by the thick paste of relative density 1.20 ~ 1.25 under filtrate simmer down to 80 DEG C of environment, for subsequent use;
(5) by juice, fine powder and the thick paste mixing obtained by above-mentioned steps (1) ~ (4), make tablet, obtain the medicine for the treatment of chronic pharyngitis of the present invention.
Usage and dosage: oral, every day 2 times, each 1 time sooner or later, each 2, warm water delivery service after meal; Within 12 days, be 1 course for the treatment of, 2 ~ 3 courses for the treatment of can fully recover, and the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
Embodiment 2
The raw material composition of effective ingredient of the present invention and weight are:
Rhizoma Nelumbinis 59g Radix Tinosporae 55g Fructus Momordicae 50g Fructus Ligustri Lucidi 49g
Caulis Bambusae In Taenia 48g Semen Armeniacae Amarum 47g Radix Cudraniae 43g Periostracum Cicadae 42g
Radix Platycodonis 40g arrowhead 38g Herba Rostellulariae 35g Herba Sonchi Oleracei 34g
Herba Houttuyniae 32g Venenum Bufonis 32g Flos Lonicerae 28g Herba Cichorii 24g.
The process for preparing medicine processing step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 3
The raw material composition of effective ingredient of the present invention and weight are:
Rhizoma Nelumbinis 55g Radix Tinosporae 50g Fructus Momordicae 46g Fructus Ligustri Lucidi 45g
Caulis Bambusae In Taenia 43g Semen Armeniacae Amarum 42g Radix Cudraniae 38g Periostracum Cicadae 38g
Radix Platycodonis 36g arrowhead 34g Herba Rostellulariae 31g Herba Sonchi Oleracei 30g
Herba Houttuyniae 28g Venenum Bufonis 28g Flos Lonicerae 25g Herba Cichorii 21g.
The process for preparing medicine processing step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 4
The raw material composition of effective ingredient of the present invention and weight are:
Rhizoma Nelumbinis 51g Radix Tinosporae 45g Fructus Momordicae 42g Fructus Ligustri Lucidi 41g
Caulis Bambusae In Taenia 38g Semen Armeniacae Amarum 37g Radix Cudraniae 33g Periostracum Cicadae 34g
Radix Platycodonis 34g arrowhead 30g Herba Rostellulariae 27g Herba Sonchi Oleracei 26g
Herba Houttuyniae 23g Venenum Bufonis 24g Flos Lonicerae 22g Herba Cichorii 18g.
The process for preparing medicine processing step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 5
The raw material composition of effective ingredient of the present invention and weight are:
Rhizoma Nelumbinis 46g Radix Tinosporae 40g Fructus Momordicae 38g Fructus Ligustri Lucidi 36g
Caulis Bambusae In Taenia 33g Semen Armeniacae Amarum 32g Radix Cudraniae 28g Periostracum Cicadae 30g
Radix Platycodonis 28g arrowhead 26g Herba Rostellulariae 23g Herba Sonchi Oleracei 22g
Herba Houttuyniae 19g Venenum Bufonis 20g Flos Lonicerae 19g Herba Cichorii 15g.
The process for preparing medicine processing step of the present embodiment and usage and dosage identical with embodiment 1.
Clinical data:
1, case selection:
As the medicine for the treatment of chronic pharyngitis, select the routine clinical observation of patients with chronic pharyngitis 166 of making a definite diagnosis, patient is divided into treatment group and matched group two groups at random, treatment group 78 example, wherein male 38 example, women 37 example, 35 ~ 70 years old age, 52.5 years old mean age, the course of disease 1 ~ 6 year; Matched group 78 example, wherein male 36 example, women 39 example, 36 ~ 71 years old age, 51.5 years old mean age, the course of disease 1 ~ 5 year; The course of disease, the degrees of symptoms for the treatment of group and matched group two groups of cases are basically identical, without significant difference, have comparability.
2, medicament selection:
Treatment group takes medicine of the present invention, oral, every day 2 times, each 1 time sooner or later, each 2, warm water delivery service after meal; Within 12 days, be 1 course for the treatment of, take 2 ~ 3 courses for the treatment of continuously, the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
Matched group takes LIYANLING PIAN, oral, one time 3 ~ 4,3 times on the one 7 ~ 14 days is a course for the treatment of or follow the doctor's advice, and the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
3, efficacy determination:
(1) cure: pharyngodynia with dryness, foreign body sensation, the clinical symptoms such as scorching hot of itching all disappear, pharyngeal without sense of discomfort.
(2) take a turn for the better: above-mentioned clinical symptom relief, pharyngeal sense of discomfort alleviates.
(3) invalid: by treating rear clinical symptoms without being clearly better or increasing the weight of.
4, result:
Using the treatment group of Drug therapy primary disease of the present invention, curing 52 examples, take a turn for the better 24 examples, invalid 2 examples, cure rate 66.7%, total effective rate 97.4%.
Using the matched group of armillarisin A tablets treatment primary disease, curing 37 examples, take a turn for the better 23 examples, invalid 18 examples, cure rate 47.4%, total effective rate 76.9%.
Above result display, the cure rate for the treatment of group and total effective rate are apparently higher than matched group.
Model case is illustrated:
1, certain is thanked, female, 38 years old, people from Hefei City, Anhui Province.Patient feels pharyngeal discomfort, drying from August, 2009, and often have burning sensation of itching, admission examination is diagnosed as chronic simple pharyngitis.Take multiple Chinese medicine and western medicine ineffective, recommend by doctor, take medicine of the present invention, after taking 2 courses for the treatment of, satisfactory effect is anti-recurrence, takes again 1 course for the treatment of, recovers, so far, do not recur.
2, certain is gone into business, man, 40 years old, people from trend in Yangquan City.Patient due to passive protective physical fitness low, frequent cold cough, causes pharyngeal discomfort, develops into chronic simple pharyngitis gradually.Admission examination, through doctor's diagnosis and treatment, start to take medicine of the present invention, take medicine 2 courses for the treatment of, while pharyngeal discomfort is alleviated substantially, passive protective physical fitness also improves gradually, and cold cough also has no recurrence, continues to take 1 course for the treatment of, and the state of an illness is fully recovered, and follows up a case by regular visits to and has no recurrence.
3, Tan, man, 55 years old, people from Guangzhou, Guangdong.Patient often feels pharyngeal foreign body sensation, Pruritus, pain, cough symptom still exist, after remove hospital admission, be diagnosed as chronic pharyngitis.Give micro-wave therapeutic, after 10 days, symptom, without obviously alleviating, stops treatment.Afterwards because going to a doctor in pharyngitis serious symptom here of coming, diagnosis finds that left side pharynx rear wall lymph follicle is formed, body of the tongue is light red, thick and greasy fur.Take 3 courses for the treatment of of medicine of the present invention, symptom disappears completely, so far half a year, not recurrence.
4, the Yan, female, 67 years old, people from Cangzhou, Hebei Province.Patient has smoking history 10 years, rises morning when brushing teeth, and pharyngeal normal sensation is felt sick, retch and with foreign body sensation, treat through multiple Chinese and western drugs, be difficult to alleviate, recurrent exerbation, to our hospitally take 3 courses for the treatment of of medicine of the present invention through doctor advised, patient clinical transference cure, follow up a case by regular visits to 1 year, the state of an illness is without recurrence.
5, poplar, man, 28 years old, teacher, people from Qingdao.Patient feels that throat dryly to be itched, had foreign body sensation for many years always, and speech can produce pharyngeal pain too much, and repeatedly recurrent exerbation after treatment, introduces to our hospital through friend, find through clinical diagnosis, pharyngeal congestion, in kermesinus, retropharyneal folliculosis, mucosal hyperplasia is plump, is chronic pharyngitis.Take 2 courses for the treatment of of medicine of the present invention, patient clinical symptom is clearly better, and continues to take 1 course for the treatment of, and clinical symptom disappearance, follows up a case by regular visits to half a year, and the state of an illness is without repeatedly.
6, Zhao, man, 41 years old, people from Yulin.Patient suffers from chronic pharyngitis 2 years, persistence laryngopharynx swelling and pain, hoarseness, the hospitalize of to too much home is gone all to have no improvement, to our hospital upon somebody's introduction, after taking 2 courses for the treatment of of medicine of the present invention, above-mentioned symptom is clearly better, after taking 3 courses for the treatment of of medicine of the present invention, symptom disappears completely, and sound recovers normal, follows up a case by regular visits to healthy so far.
Claims (5)
1. treat a medicine for chronic pharyngitis, it is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:
Rhizoma Nelumbinis 42 ~ 68 portions of Radix Tinosporaes 35 ~ 65 portions of Fructus Momordicaes 34 ~ 58 parts of Fructus Ligustri Lucidi 32 ~ 57 parts
Caulis Bambusae In Taenia 28 ~ 58 parts of Semen Armeniacae Amarums 27 ~ 57 parts of Radix Cudraniaes 23 ~ 53 portions of Periostracum Cicadaes 26 ~ 51 parts
Radix Platycodonis 23 ~ 48 parts of arrowheads 21 ~ 47 parts of Herba Rostellulariaes 19 ~ 43 parts of Herba Sonchi Oleracei 18 ~ 42 parts
Herba Houttuyniae 15 ~ 40 parts of Venenum Bufoniss 16 ~ 40 portions of Flos Loniceraes 16 ~ 34 portions of Herba Cichoriis 12 ~ 30 parts.
2. a kind of medicine for the treatment of chronic pharyngitis according to claim 1, is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:
Rhizoma Nelumbinis 46 ~ 64 portions of Radix Tinosporaes 40 ~ 60 portions of Fructus Momordicaes 38 ~ 54 parts of Fructus Ligustri Lucidi 36 ~ 53 parts
Caulis Bambusae In Taenia 33 ~ 53 parts of Semen Armeniacae Amarums 32 ~ 52 parts of Radix Cudraniaes 28 ~ 48 portions of Periostracum Cicadaes 30 ~ 47 parts
Radix Platycodonis 28 ~ 44 parts of arrowheads 26 ~ 42 parts of Herba Rostellulariaes 23 ~ 39 parts of Herba Sonchi Oleracei 22 ~ 38 parts
Herba Houttuyniae 19 ~ 36 parts of Venenum Bufoniss 20 ~ 36 portions of Flos Loniceraes 19 ~ 31 portions of Herba Cichoriis 15 ~ 27 parts.
3. a kind of medicine for the treatment of chronic pharyngitis according to claim 1, is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:
Rhizoma Nelumbinis 51 ~ 59 portions of Radix Tinosporaes 45 ~ 55 portions of Fructus Momordicaes 42 ~ 50 parts of Fructus Ligustri Lucidi 41 ~ 49 parts
Caulis Bambusae In Taenia 38 ~ 48 parts of Semen Armeniacae Amarums 37 ~ 47 parts of Radix Cudraniaes 33 ~ 43 portions of Periostracum Cicadaes 34 ~ 42 parts
Radix Platycodonis 34 ~ 40 parts of arrowheads 30 ~ 38 parts of Herba Rostellulariaes 27 ~ 35 parts of Herba Sonchi Oleracei 26 ~ 34 parts
Herba Houttuyniae 23 ~ 32 parts of Venenum Bufoniss 24 ~ 32 portions of Flos Loniceraes 22 ~ 28 portions of Herba Cichoriis 18 ~ 24 parts.
4. a kind of medicine for the treatment of chronic pharyngitis according to claim 1, is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:
Rhizoma Nelumbinis 55 portions of Radix Tinosporaes 50 portions of Fructus Momordicaes 46 parts of Fructus Ligustri Lucidi 45 parts
Caulis Bambusae In Taenia 43 parts of Semen Armeniacae Amarums 42 parts of Radix Cudraniaes 38 portions of Periostracum Cicadaes 38 parts
Radix Platycodonis 36 parts of arrowheads 34 parts of Herba Rostellulariaes 31 parts of Herba Sonchi Oleracei 30 parts
Herba Houttuyniae 28 parts of Venenum Bufoniss 28 portions of Flos Loniceraes 25 portions of Herba Cichoriis 21 parts.
5. as described in any one of Claims 1 to 4, treat a preparation method for the medicine of chronic pharyngitis, it is characterized in that: comprise following processing step:
(1) Rhizoma Nelumbinis and Herba Sonchi Oleracei are cleaned, shady and cool place dries, and chopping, puts into container, strand juice, and filter impurity, stays juice for subsequent use;
(2) Radix Tinosporae, Semen Armeniacae Amarum, Periostracum Cicadae and Herba Houttuyniae are mixed, carry out pulverization process after mix homogeneously, grind into powder, cross 160 order fine powders, for subsequent use;
(3) Fructus Momordicae, Fructus Ligustri Lucidi, Caulis Bambusae In Taenia, Radix Platycodonis, arrowhead and Herba Rostellulariae are cleaned, put into container, add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate, being condensed into relative density at 60 DEG C is the thick paste of 1.10 ~ 1.16, for subsequent use;
(4) Radix Cudraniae, Venenum Bufonis, Flos Lonicerae and Herba Cichorii are cleaned, immerse the alcohol solution dipping 3 ~ 4 hours of 85% of 8 times amount, heating and refluxing extraction 2 ~ 3 hours, reclaim ethanol, filter, by the thick paste of relative density 1.20 ~ 1.25 under filtrate simmer down to 80 DEG C of environment, for subsequent use;
(5) by juice, fine powder and the thick paste mixing obtained by above-mentioned steps (1) ~ (4), make tablet, obtain the medicine of described treatment chronic pharyngitis.
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