CN104352667A - Medicine for treating nonspecific vaginitis and preparation method - Google Patents

Medicine for treating nonspecific vaginitis and preparation method Download PDF

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CN104352667A
CN104352667A CN201410654865.XA CN201410654865A CN104352667A CN 104352667 A CN104352667 A CN 104352667A CN 201410654865 A CN201410654865 A CN 201410654865A CN 104352667 A CN104352667 A CN 104352667A
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herba
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nonspecific vaginitis
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刘岚
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Abstract

The invention discloses a medicine for treating nonspecific vaginitis and a preparation method, belonging to the field of traditional Chinese medicines. The effective components of the medicine disclosed by the invention are prepared from the raw materials: bombardier beetle, cucubalus root, radix bupleuri, cynanchum thesioides, ghostplant wormwood herb, virginia creeper, starwort, wintercreeper, herb of glabrous sarcandra, plumbago indica, herba lycopi, human placenta, swimming crab meat, tabasheer, leonurus pseudomacranthus and horehound. Because medicinal materials in the medicine are compatible and suitable, the medicine disclosed by the invention accords with theories of traditional Chinese medicine and pharmacy and modern medicine and pharmacology, has the effects of clearing heat, removing toxicity, killing insects to relieve itching, dissipating stasis and stopping bleeding, and has obvious curative effects for treating nonspecific vaginitis; furthermore, the medicine has the advantages of being short in treatment course, rapid to take effect, convenient to take, low in cost, free from toxic and side effect, strange in effect and practical, and is capable of treating both symptoms and root causes of nonspecific vaginitis; nonspecific vaginitis difficultly relapses after being healed; and thus, the medicine disclosed by the invention is worthy of being widely popularized and applied.

Description

A kind of medicine and preparation method for the treatment of nonspecific vaginitis
Art
The present invention relates to the field of Chinese medicines, particularly relate to a kind of medicine and preparation method for the treatment of nonspecific vaginitis.
Background technology
Nonspecific vaginitis is a kind of common gynaecopathia, itself can't cause very serious consequence, treat also relatively simple, but because a lot of gynaecopathia is as vaginitis, even malignant tumor such as cervical cancer etc. also has similar symptom, therefore female friend is when occurring leucorrhoea grow in quantity, vagina abnormal flavour, also do not adopt a casual attitude.Nonspecific vaginitis is by general pathogen, as the vaginitis that Bacillus proteus, streptococcus, staphylococcus, escherichia coli etc. cause, this disease is also relevant with the infection of haemophilus, mycoplasma, various anaerobe, be also called vaginitis hemoptulus vaginalis, corynebacterium vaginale vaginitis, Gardner's bacilus vaginitis, and bacterial vaginitis.The patient of about 50% does not have symptom.This kind ofly to lack of proper care the syndrome that the vaginal secretions caused increases, leucorrhea has fish bad smell and pruritus vulvae is scorching hot due to intravaginal microecological balance, and vagina lacks inflammation, and the equal NIP of clinical pathology feature changes, therefore is called vaginosis.
Inflammation is multiple is born in nympha medial and lateral or the even whole external genital of labium majus, acute stage, main manifestations was cunnus hyperraemia, edema, erosion, patient has burning sensation, pain, pruritus, difficulty in walking etc., eczema, ulcer or pustule can be there is in severe patient, even cellulitis, sometimes can with inguinal lymphadenopathy, tenderness.Chronic patients, due to long-time stimulus, can occur pachyderma, coarse, chap, sometimes in lichenization or hypopigmentation.
Current treatment nonspecific vaginitis mostly is mainly with western medical treatment and puts into antibiotic powder in intravaginal, but life-time service can cause local flora to be lacked of proper care, and causes larger puzzlement.And use antibiotic medicine, easy drug resistance, the easy recurrent exerbation of disease, bring considerable distress to patient.
Summary of the invention
The invention provides a kind of medicine and preparation method for the treatment of nonspecific vaginitis; Selected by medicine of the present invention, medical material compatibility is suitable, meets Chinese medicine and pharmacy and modern medicine theory, and has effect of heat-clearing and toxic substances removing, killing parasites for relieving itching, dissipating blood stasis hemostasis, to treatment nonspecific vaginitis, there is significant curative effect, short treating period, instant effect, taking convenience, with low cost, have no side effect, non-relapse after healing, can reach the object for the treatment of both the principal and secondary aspects of a disease to the treatment of nonspecific vaginitis, special effect is practical, wide popularization and application on clinic.
For achieving the above object, technical scheme of the present invention is implemented as follows:
Treat a medicine for nonspecific vaginitis, raw material composition and the parts by weight of making described effective ingredient are:
Pheropsophus jessoensis Mor. 33 ~ 56 parts of Radix Cucubalis 30 ~ 54 parts of Radix Bupleuri 29 ~ 53 parts of Herba Cynanchi Thesioidis 27 ~ 51 parts
Herba artemisiae lactiflorae 25 ~ 49 parts hangs rock wind 23 ~ 47 parts of Herba stellariae mediaes 22 ~ 46 portions of Caulis Seu Folium Euonymi Fortuneis 21 ~ 45 parts
Herba Sarcandrae 18 ~ 42 parts of Herba plumbaginis indicaes 17 ~ 41 parts of Herba Lycopi 14 ~ 38 parts of Placenta Hominiss 12 ~ 36 parts
Charybdis japonica 10 ~ 34 parts of Concretio silicea Bambusae seu schizostachyis 8 ~ 31 parts of Herba leonuri pseudoma cranthi 8 ~ 27 parts of Herba lagopsis supinaes 5 ~ 23 parts.
Raw material composition and the parts by weight of making described effective ingredient are:
Pheropsophus jessoensis Mor. 36 ~ 52 parts of Radix Cucubalis 34 ~ 50 parts of Radix Bupleuri 33 ~ 49 parts of Herba Cynanchi Thesioidis 31 ~ 47 parts
Herba artemisiae lactiflorae 29 ~ 45 parts hangs rock wind 27 ~ 43 parts of Herba stellariae mediaes 26 ~ 42 portions of Caulis Seu Folium Euonymi Fortuneis 25 ~ 41 parts
Herba Sarcandrae 22 ~ 38 parts of Herba plumbaginis indicaes 21 ~ 37 parts of Herba Lycopi 18 ~ 34 parts of Placenta Hominiss 16 ~ 32 parts
Charybdis japonica 14 ~ 30 parts of Concretio silicea Bambusae seu schizostachyis 12 ~ 27 parts of Herba leonuri pseudoma cranthi 11 ~ 23 parts of Herba lagopsis supinaes 8 ~ 20 parts.
Raw material composition and the parts by weight of making described effective ingredient are:
Pheropsophus jessoensis Mor. 40 ~ 48 parts of Radix Cucubalis 38 ~ 46 parts of Radix Bupleuri 37 ~ 45 parts of Herba Cynanchi Thesioidis 35 ~ 43 parts
Herba artemisiae lactiflorae 33 ~ 41 parts hangs rock wind 31 ~ 39 parts of Herba stellariae mediaes 30 ~ 38 portions of Caulis Seu Folium Euonymi Fortuneis 29 ~ 37 parts
Herba Sarcandrae 26 ~ 34 parts of Herba plumbaginis indicaes 25 ~ 33 parts of Herba Lycopi 22 ~ 30 parts of Placenta Hominiss 20 ~ 28 parts
Charybdis japonica 18 ~ 26 parts of Concretio silicea Bambusae seu schizostachyis 15 ~ 23 parts of Herba leonuri pseudoma cranthi 14 ~ 20 parts of Herba lagopsis supinaes 11 ~ 17 parts.
Raw material composition and the parts by weight of making described effective ingredient are:
Pheropsophus jessoensis Mor. 44 parts of Radix Cucubalis 42 parts of Radix Bupleuri 41 parts of Herba Cynanchi Thesioidis 39 parts
Herba artemisiae lactiflorae 37 parts hangs rock wind 35 parts of Herba stellariae mediaes 34 portions of Caulis Seu Folium Euonymi Fortuneis 33 parts
Herba Sarcandrae 30 parts of Herba plumbaginis indicaes 29 parts of Herba Lycopi 26 parts of Placenta Hominiss 24 parts
Charybdis japonica 22 parts of Concretio silicea Bambusae seu schizostachyis 19 parts of Herba leonuri pseudoma cranthi 17 parts of Herba lagopsis supinaes 14 parts.
Treat a preparation method for the medicine of nonspecific vaginitis, comprise following processing step:
(1) Pheropsophus jessoensis Mor., Placenta Hominis, Charybdis japonica and Herba leonuri pseudoma cranthi are put into container, carry out pulverization process, grind into powder, cross 180 orders, obtain fine powder, for subsequent use;
(2) by Radix Cucubali, Herba Cynanchi Thesioidis, hang rock wind, Herba plumbaginis indicae, Herba Lycopi, Concretio silicea Bambusae seu schizostachyi and Herba lagopsis supinae and clean, put into container, add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate, being condensed into relative density at 60 DEG C is the thick paste of 1.10 ~ 1.13, for subsequent use;
(3) by Radix Bupleuri decontamination, clean, section, dries, is placed in container, mixes thoroughly with vinegar, puts in pot to fry with slow fire to exhaust and micro-dry to vinegar, takes out, dries, be placed in mortar, grind into powder, cross 200 orders, fine powder is for subsequent use;
(4) Herba artemisiae lactiflorae and Herba stellariae mediae are cleaned, chopping, puts into container, strand juice, and filter impurity, stays juice for subsequent use;
(5) Caulis Seu Folium Euonymi Fortunei and Herba Sarcandrae are cleaned, immerse the alcohol solution dipping 1 ~ 2 hour of 60% of 3 times amount, heating extraction 3 hours, reclaim ethanol, filter, obtain filtrate, at simmer down to 65 DEG C, relative density is the thick paste of 1.12 ~ 1.16, for subsequent use;
(6) by fine powder, thick paste and the juice mixing obtained by above-mentioned steps (1) ~ (5), make tablet, obtain the medicine for the treatment of nonspecific vaginitis of the present invention.
The property of medicine of the present invention's Chinese medicine used is as follows:
Pheropsophus jessoensis Mor.: acrid in the mouth, warm in nature; Return Liver Channel.Blood circulation promoting and blood stasis dispelling, antalgic.Main cold stasis of blood amenorrhea, dysmenorrhea, the stagnant stomachache of the stasis of blood in puerperal, lump in the abdomen, traumatic injury stasis of blood pain." not Lu " carries: " treat stomachache, cold and heat, sharp blood.”
Radix Cucubali: sweet in the mouth, hardship, property is put down; Return liver, spleen channel.Blood circulation promoting and blood stasis dispelling, treating stranguria let out turbid, removing toxic substances and promoting subsidence of swelling.Cure mainly dysmenorrhea due to blood stasis, amenorrhea, vicarious menstruation, lump in the abdomen lumps, and pyretic stranguria, stranguria with blood, nebulousurine, leucorrhea, arthralgia pain enters network, passages through which vital energy circulates contracture, traumatic injury, carbuncle sore tumefacting virus, tonsillitis, diphtheria." Yunnan Chinese herbal medicine " carries: " inducing diuresis to remove edema is hastened parturition.Control hernia, edema, pulmonary tuberculosis, difficult labour, retention of dead fetus.”
Radix Bupleuri: bitter in the mouth, pungent, cold nature; Return liver, gallbladder meridian.Depressed liver-energy dispersing and function of gallbladder promoting, dredges gas resolving depression, and loose fiery expelling pathogenic factors from the exterior, expels the heat-evil, dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy.Cure mainly cold, fever, cold and heat deficient fever, children's's varioliform exanthema waste heat, emaciation and sallow complexion abdominal part expands, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, and uterus comes off, menoxenia.Modern medicine study confirms, the heating of Radix Bupleuri decoct has obvious refrigeration function, all has inhibitory action to the inflammation caused by multiple proinflammatory agent, and can Promote immunity function.
Herba Cynanchi Thesioidis: sweet in the mouth, cool in nature; Return lung meridian.Tonifying the lung gas, resolving heat and reducing pathogenic fire, promoting the production of body fluid to quench thirst, anti-inflammatory analgetic.Main hyperactivity of deficient fire, has sore throat, deficiency of both vital energy and Yin, and Mental fatigue is forgetful, and fidgets due to deficiency is thirsty, dizzy insomnia, puerperal asthenia, hypogalactia.
Herba artemisiae lactiflorae: sweet in the mouth, micro-hardship, property is put down.Vital energy regualting and blood circulation-promoting, regulating menstruation dampness removing, removing toxic substances and promoting subsidence of swelling.For menoxenia, amenorrhea, chronic hepatitis, liver cirrhosis, oedema due to nephritis, leucorrhea, urticaria, abdominal distention, hernia; Traumatic injury is controlled in external, traumatic hemorrhage, burn and scald, skin infection, eczema." south of the Five Ridges gather medicinal herbs record " carries: " promoting blood circulation to restore menstrual flow, treats cholera watery diarrhea, and only incised wound is hemorrhage.Control burn, heart pain, watery distension, size is had blood in stool.”
Hang rock wind: sour in the mouth, puckery, warm in nature.Dispelling, collateral-activating, promoting blood circulation and stopping pain.For bones and muscles pain due to rheumatism, leucorrhea with red and white discharge, puerperal abdonimal pain; Fracture is controlled in external, treating swelling and pain by traumatic injury, furuncle.
Herba stellariae mediae: sweet in the mouth, acid, cool in nature.Heat-clearing and toxic substances removing, blood-activating analgetic, lactogenic.For enteritis, dysentery, hepatitis, appendicitis, postnatal blood stasis is suffered from abdominal pain, uterine contraction pain, toothache, early whitening of hair, agalactia, mastitis, traumatic injury, sore swollen toxin." Bencao Tujing " carries: " wipe tooth a surname dew, dry work is not useful.”
Caulis Seu Folium Euonymi Fortunei: bitter in the mouth, sweet, warm in nature.Dissipating blood stasis stops blooding, relaxing muscles and tendons and activating QI and blood in the collateral.For spitting of blood, menoxenia, dysfunctional uterine hemorrhage, rheumatic arthralgia; Traumatic injury is controlled in external, fracture, wound hemorrhage." will planted by Tianmu Mountains of Zhejiang Province medicine " carries: " promoting flow of QI and blood.Control lumbocrural pain, joint aches.”
Herba Sarcandrae: bitter in the mouth, pungent, property is put down; GUIXIN, Liver Channel.Expelling wind and removing dampness, promoting blood circulation to remove blood stasis, heat-clearing and toxic substances removing.Main numb limbs and tense tendons, traumatic injury, fracture, dysmenorrhes, the stagnant stomachache of the stasis of blood in puerperal, pneumonia, striving property appendicitis, acute gastroenteritis, bacillary dysentery, cholecystitis, abscess, stomatitis, rheumatic arthralgia.
Herba plumbaginis indicae: acrid in the mouth, hardship, warm in nature, mild toxicity.Removing blood stasis stimulates the menstrual flow, reducing swelling and alleviating pain, cestode of dispeling the wind.Main dysmenorrhea, amenorrhea, rheumatic arthralgia, osteopatia sprain, carbuncle sore tumefacting virus, scabies exudative dermatitis." Luchuan book on Chinese herbal medicine " carries: " removing blood stasis, pain relieving, the menstruation of logical tune.Control menstruation apolipsis, abdominal pain in menstruation, exudative dermatitis, ulcer.”
Herba Lycopi: bitter in the mouth, pungent, slightly warm in nature; Return liver, spleen channel.Blood circulation promoting and blood stasis dispelling, line water detumescence.For menoxenia, amenorrhea, dysmenorrhea, postnatal blood stasis is suffered from abdominal pain, edema." property of medicine opinion " carries: " main puerperal abdonimal pain, frequently produce vim and vigour and to decline cold one-tenth labor, thin win, controls again the whole body appearance swollen greatly, housewife's human blood drop lumbago.”
Placenta Hominis: sweet in the mouth, salty, warm in nature; Return lung, liver, kidney channel.QI invigorating, nourishes blood, benefit essence.Control deficient, weakness and emaciation, consumptive fever hectic fever due to YIN-deficiency, cough with asthma, spitting of blood, night sweat, seminal emission, sexual impotence, women's vim and vigour are not enough, infertile or newborn few." about can cure mirror " carries: " ulna steams night sweat, and lumbago knee joint is soft, and the thin essence of body is withered, all can tonification." modern medicine study thinks; Placenta Hominis inner protein, sugar, calcium, vitamin, immune factor, estrogen, gravidity assisting ketone, steroid hormone, promoting sexual gland hormone, thyroliberin etc.; the growth of mammary gland, uterus, vagina, testis can be promoted; also have facilitation to thyroid; also have good effect to pulmonary tuberculosis, bronchial asthma, anemia etc., grind oral or coloclysis into powder and can prevent measles or mitigation symptoms.
Charybdis japonica: salty in the mouth, micro-pungent, warm in nature; Return spleen, stomach warp.Blood circulation promoting and blood stasis dispelling, help digestion lactogenesis.Main blood stasis amenorrhea, the stagnant stomachache of the stasis of blood in puerperal, dyspepsia, food stagnation feeling of fullness, newborn method is not enough." Japan hanako materia medica " carries: " separate steam, control children's's mass at the hypochondrium.”
Concretio silicea Bambusae seu schizostachyi: lightly seasoned, property is put down; Enter the heart, liver, gallbladder meridian.Expelling wind and removing dampness, easypro warp of invigorating blood circulation, cough-relieving.For rheumatic arthralgia, numb limbs and tense tendons, infantile pertussis, leukorrhagia.There is meaning still can control gastropathy." Kaibao Bencao " carries: " main infantile convulsion sky hangs, and all wind heat are gone in relieving palpitation improving eyesight, treats incised wound hemostasis, nourishes the five internal organs.”
Herba leonuri pseudoma cranthi: acrid in the mouth, micro-hardship, cold nature.Promoting blood flow to regulate menstruation, removing toxic substances and promoting subsidence of swelling.Main menoxenia, amenorrhea, dysmenorrhea, postnatal blood stasis is suffered from abdominal pain, metrorrhagia, traumatic pain, carbuncle sore.Supplement to the Herbal carries: " main removing blood stasis.Puerperal abdonimal pain, liquor takes it; Also deposited furuncle is smashed to pieces.”
Herba lagopsis supinae: acrid in the mouth, micro-hardship, cold in nature; Return Liver Channel.Nourshing blood and promoting blood circulation, clearing away heat-damp and promoting diuresis.Main menoxenia, the stagnant stomachache of the stasis of blood in puerperal, blood deficiency is dizzy, and it is unsuccessful partly to penetrate, traumatic injury, edema, dysuria, conjunctival congestion and swelling pain, carbuncle sore, chilblain, toothache, erythra pruritus." Shaanxi Chinese herbal medicine " carries: " invigorate blood circulation, regulating menstruation.Eliminate-poverty is courageous and upright dizzy, hemiplegia, menoxenia.”
The present invention compared with prior art, has following beneficial effect:
Selected by medicine of the present invention, medical material compatibility is suitable, meets Chinese medicine and pharmacy and modern medicine theory, and has effect of heat-clearing and toxic substances removing, killing parasites for relieving itching, dissipating blood stasis hemostasis, to treatment nonspecific vaginitis, there is significant curative effect, short treating period, instant effect, taking convenience, with low cost, have no side effect, non-relapse after healing, can reach the object for the treatment of both the principal and secondary aspects of a disease to the treatment of nonspecific vaginitis, special effect is practical, wide popularization and application on clinic.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
The raw material composition of effective ingredient of the present invention and weight are:
Pheropsophus jessoensis Mor. 52g Radix Cucubali 50g Radix Bupleuri 49g Herba Cynanchi Thesioidis 47g
Herba artemisiae lactiflorae 45g hangs rock wind 43g Herba stellariae mediae 42g Caulis Seu Folium Euonymi Fortunei 41g
Herba Sarcandrae 38g Herba plumbaginis indicae 37g Herba Lycopi 34g Placenta Hominis 32g
Charybdis japonica 30g Concretio silicea Bambusae seu schizostachyi 27g Herba leonuri pseudoma cranthi 23g Herba lagopsis supinae 20g.
The preparation method of medicine of the present invention, comprises following processing step:
(1) Pheropsophus jessoensis Mor., Placenta Hominis, Charybdis japonica and Herba leonuri pseudoma cranthi are put into container, carry out pulverization process, grind into powder, cross 180 orders, obtain fine powder, for subsequent use;
(2) by Radix Cucubali, Herba Cynanchi Thesioidis, hang rock wind, Herba plumbaginis indicae, Herba Lycopi, Concretio silicea Bambusae seu schizostachyi and Herba lagopsis supinae and clean, put into container, add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate, being condensed into relative density at 60 DEG C is the thick paste of 1.10 ~ 1.13, for subsequent use;
(3) by Radix Bupleuri decontamination, clean, section, dries, is placed in container, mixes thoroughly with vinegar, puts in pot to fry with slow fire to exhaust and micro-dry to vinegar, takes out, dries, be placed in mortar, grind into powder, cross 200 orders, fine powder is for subsequent use;
(4) Herba artemisiae lactiflorae and Herba stellariae mediae are cleaned, chopping, puts into container, strand juice, and filter impurity, stays juice for subsequent use;
(5) Caulis Seu Folium Euonymi Fortunei and Herba Sarcandrae are cleaned, immerse the alcohol solution dipping 1 ~ 2 hour of 60% of 3 times amount, heating extraction 3 hours, reclaim ethanol, filter, obtain filtrate, at simmer down to 65 DEG C, relative density is the thick paste of 1.12 ~ 1.16, for subsequent use;
(6) by fine powder, thick paste and the juice mixing obtained by above-mentioned steps (1) ~ (5), make tablet, obtain the medicine for the treatment of nonspecific vaginitis of the present invention.
Usage and dosage: oral, every day 2 times, each 1 time sooner or later, each 2 (every sheet 0.4g), warm water delivery service after meal; Within 6 days, be 1 course for the treatment of, 2 ~ 3 courses for the treatment of can fully recover, and the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
Embodiment 2
The raw material composition of effective ingredient of the present invention and weight are:
Pheropsophus jessoensis Mor. 48g Radix Cucubali 46g Radix Bupleuri 45g Herba Cynanchi Thesioidis 43g
Herba artemisiae lactiflorae 41g hangs rock wind 39g Herba stellariae mediae 38g Caulis Seu Folium Euonymi Fortunei 37g
Herba Sarcandrae 34g Herba plumbaginis indicae 33g Herba Lycopi 30g Placenta Hominis 28g
Charybdis japonica 26g Concretio silicea Bambusae seu schizostachyi 23g Herba leonuri pseudoma cranthi 20g Herba lagopsis supinae 17g.
The process for preparing medicine processing step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 3
The raw material composition of effective ingredient of the present invention and weight are:
Pheropsophus jessoensis Mor. 44g Radix Cucubali 42g Radix Bupleuri 41g Herba Cynanchi Thesioidis 39g
Herba artemisiae lactiflorae 37g hangs rock wind 35g Herba stellariae mediae 34g Caulis Seu Folium Euonymi Fortunei 33g
Herba Sarcandrae 30g Herba plumbaginis indicae 29g Herba Lycopi 26g Placenta Hominis 24g
Charybdis japonica 22g Concretio silicea Bambusae seu schizostachyi 19g Herba leonuri pseudoma cranthi 17g Herba lagopsis supinae 14g.
The process for preparing medicine processing step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 4
The raw material composition of effective ingredient of the present invention and weight are:
Pheropsophus jessoensis Mor. 40g Radix Cucubali 38g Radix Bupleuri 37g Herba Cynanchi Thesioidis 35g
Herba artemisiae lactiflorae 33g hangs rock wind 31g Herba stellariae mediae 30g Caulis Seu Folium Euonymi Fortunei 29g
Herba Sarcandrae 26g Herba plumbaginis indicae 25g Herba Lycopi 22g Placenta Hominis 20g
Charybdis japonica 18g Concretio silicea Bambusae seu schizostachyi 15g Herba leonuri pseudoma cranthi 14g Herba lagopsis supinae 11g.
The process for preparing medicine processing step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 5
The raw material composition of effective ingredient of the present invention and weight are:
Pheropsophus jessoensis Mor. 36g Radix Cucubali 34g Radix Bupleuri 33g Herba Cynanchi Thesioidis 31g
Herba artemisiae lactiflorae 29g hangs rock wind 27g Herba stellariae mediae 26g Caulis Seu Folium Euonymi Fortunei 25g
Herba Sarcandrae 22g Herba plumbaginis indicae 21g Herba Lycopi 18g Placenta Hominis 16g
Charybdis japonica 14g Concretio silicea Bambusae seu schizostachyi 12g Herba leonuri pseudoma cranthi 11g Herba lagopsis supinae 8g.
The process for preparing medicine processing step of the present embodiment and usage and dosage identical with embodiment 1.
Clinical data:
1, case selection:
As the medicine for the treatment of nonspecific vaginitis, select the routine clinical observation of nonspecific vaginitis patient 170 of making a definite diagnosis, patient is divided into treatment group and matched group two groups at random, treatment group women 85 example, 20 ~ 51 years old age, 35.5 years old mean age, average course of disease 3 years; Matched group women 85 example, 21 ~ 50 years old age, 35.5 years old mean age, average course of disease 3 years.
The course of disease, the degrees of symptoms for the treatment of group and matched group two groups of cases are basically identical, without significant difference, have comparability.
2, medicament selection:
Treatment group takes medicine of the present invention, oral, every day 2 times, each 1 time sooner or later, each 2 (every sheet 0.4g), warm water delivery service after meal; Within 6 days, be 1 course for the treatment of, 2 ~ 3 courses for the treatment of can fully recover, and the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
Matched group takes Amoxicillin Tablets, oral, a 0.5 ~ 1g, 3 ~ 4 times on the one; Children's's per kilogram of body weight 0.05 ~ 0.1g on the one, divide and take for 3 ~ 4 times, the course for the treatment of is depending on the state of an illness.
3, efficacy determination:
(1) cure: cardinal symptom all disappears, and physical recovery is normal.
(2) effective: cardinal symptom obviously alleviates, health takes a turn for the better to some extent.
(3) effective: cardinal symptom alleviates to some extent, and health is clearly better.
(4) invalid: by treating rear cardinal symptom without alleviating or increasing the weight of.
4, result:
Select in the treatment group of medicine of the present invention, cure 52 examples, effective 20 examples, effective 11 examples, invalid 2 examples, cure rate 61.2%, total effective rate 97.6%.
31 examples are cured, effective 17 examples, effective 9 examples, invalid 28 examples, cure rate 36.5%, total effective rate 67.1% in matched group.
Above result display, the cure rate for the treatment of group and total effective rate are apparently higher than matched group.
Model case is illustrated:
1, Wei, female, 22 years old, people from Jilin songyuan.Patient breaks 28 days puerperal of abdomen, also has blood flow to go out till now, uses Liao Jitian sanitary towel, and red and swollen pruritus appears in pudendum local.Suffer from nonspecific vaginitis on inspection, take Drug therapy of the present invention, after taking the 1st course for the treatment of, symptom obviously alleviates, and after taking the 2nd course for the treatment of, symptom all disappears, and follows up a case by regular visits to and do not recur after 1 year.
2, Qiu, female, 30 years old, people from Weihai in Shandong province.Patient feels that some discomfort of health removes examination in hospital, and result checks out to suffer from nonspecific vaginitis, uses multiple method to treat, and only serves temporary relieve, and will recur after a time, and can not cure.To our hospital afterwards, take Drug therapy of the present invention, after taking 1 course for the treatment of, patient feels health and is clearly better, and after taking the 2nd course for the treatment of, transference cure, follows up a case by regular visits to after half a year without recurrence.
3, health, female, 25 years old, Quanzhou, Fujian people.Patient's pruritus vulvae, goes to gynaecologic hospital inspection, is diagnosed as nonspecific vaginitis, doctor recommends to take Drug therapy of the present invention, every day 2 times, each 1 time sooner or later, each 2 (every sheet 0.4g), warm water delivery service after meal, after taking 1 course for the treatment of, pruritis is clearly better, after taking 2 courses for the treatment of of medicine of the present invention, pruritis all disappears, and recovery from illness, follows up a case by regular visits to and do not recur so far.
4, Cui, female, 28 years old, people from Shaoguan, Guangdong.Patient's summer and autumn, conscious pruritus of vagina, was difficult to stand, and find through gynecologial examination, visible vagina has petechia, many places, is diagnosed as nonspecific vaginitis, uses many Drug therapys, and does not feel any better.To our hospital afterwards, take Drug therapy of the present invention, after taking 1 course for the treatment of, pruritis obviously alleviates, and after continuing to take 2 courses for the treatment of, pruritis all disappears, recovery from illness, follows up a case by regular visits to without recurrence after 1 year.
5, Xue, female, 34 years old, Sichuan Guangyuan people.Patient's leukorrhagia, the scorching hot pruritus of pudendum, has pain symptom during vagina, remove examination in hospital, be confirmed as nonspecific vaginitis, patient used several drugs to treat, Relapse rate situation is more, easily recurs, and leucorrhea is denseer thick, carry out inspection treatment with my institute afterwards, take Drug therapy of the present invention, after taking 1 course for the treatment of, pruritis alleviates to some extent, and after taking 2 courses for the treatment of, pruritis all disappears, physical recovery is healthy, can normally work and live, follow up a case by regular visits to and do not recur so far.
6, the Yan, female, 29 years old, zhuzhou,hunan people.Patient tells 20 days post-abortions, bean dregs sample leucorrhoea grow in quantity companion pudendum causalgia acute pruritus, frequent micturition dysurea.Gynecologial examination display posterior fornix of vagina has volume leucorrhea, and in white stiff curdled milk sample, the visible scratch of pudendum, is diagnosed as nonspecific vaginitis.Take Drug therapy of the present invention, after taking medicine of the present invention 1 curative effect, symptom is alleviated to some extent, and after continuing to take 1 course for the treatment of, transference cure, follows up a case by regular visits to after 2 years and do not recur.

Claims (5)

1. treat a medicine for nonspecific vaginitis, it is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:
Pheropsophus jessoensis Mor. 33 ~ 56 parts of Radix Cucubalis 30 ~ 54 parts of Radix Bupleuri 29 ~ 53 parts of Herba Cynanchi Thesioidis 27 ~ 51 parts
Herba artemisiae lactiflorae 25 ~ 49 parts hangs rock wind 23 ~ 47 parts of Herba stellariae mediaes 22 ~ 46 portions of Caulis Seu Folium Euonymi Fortuneis 21 ~ 45 parts
Herba Sarcandrae 18 ~ 42 parts of Herba plumbaginis indicaes 17 ~ 41 parts of Herba Lycopi 14 ~ 38 parts of Placenta Hominiss 12 ~ 36 parts
Charybdis japonica 10 ~ 34 parts of Concretio silicea Bambusae seu schizostachyis 8 ~ 31 parts of Herba leonuri pseudoma cranthi 8 ~ 27 parts of Herba lagopsis supinaes 5 ~ 23 parts.
2. a kind of medicine for the treatment of nonspecific vaginitis according to claim 1, is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:
Pheropsophus jessoensis Mor. 36 ~ 52 parts of Radix Cucubalis 34 ~ 50 parts of Radix Bupleuri 33 ~ 49 parts of Herba Cynanchi Thesioidis 31 ~ 47 parts
Herba artemisiae lactiflorae 29 ~ 45 parts hangs rock wind 27 ~ 43 parts of Herba stellariae mediaes 26 ~ 42 portions of Caulis Seu Folium Euonymi Fortuneis 25 ~ 41 parts
Herba Sarcandrae 22 ~ 38 parts of Herba plumbaginis indicaes 21 ~ 37 parts of Herba Lycopi 18 ~ 34 parts of Placenta Hominiss 16 ~ 32 parts
Charybdis japonica 14 ~ 30 parts of Concretio silicea Bambusae seu schizostachyis 12 ~ 27 parts of Herba leonuri pseudoma cranthi 11 ~ 23 parts of Herba lagopsis supinaes 8 ~ 20 parts.
3. a kind of medicine for the treatment of nonspecific vaginitis according to claim 1, is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:
Pheropsophus jessoensis Mor. 40 ~ 48 parts of Radix Cucubalis 38 ~ 46 parts of Radix Bupleuri 37 ~ 45 parts of Herba Cynanchi Thesioidis 35 ~ 43 parts
Herba artemisiae lactiflorae 33 ~ 41 parts hangs rock wind 31 ~ 39 parts of Herba stellariae mediaes 30 ~ 38 portions of Caulis Seu Folium Euonymi Fortuneis 29 ~ 37 parts
Herba Sarcandrae 26 ~ 34 parts of Herba plumbaginis indicaes 25 ~ 33 parts of Herba Lycopi 22 ~ 30 parts of Placenta Hominiss 20 ~ 28 parts
Charybdis japonica 18 ~ 26 parts of Concretio silicea Bambusae seu schizostachyis 15 ~ 23 parts of Herba leonuri pseudoma cranthi 14 ~ 20 parts of Herba lagopsis supinaes 11 ~ 17 parts.
4. a kind of medicine for the treatment of nonspecific vaginitis according to claim 1, is characterized in that: raw material composition and the parts by weight of making described effective ingredient are:
Pheropsophus jessoensis Mor. 44 parts of Radix Cucubalis 42 parts of Radix Bupleuri 41 parts of Herba Cynanchi Thesioidis 39 parts
Herba artemisiae lactiflorae 37 parts hangs rock wind 35 parts of Herba stellariae mediaes 34 portions of Caulis Seu Folium Euonymi Fortuneis 33 parts
Herba Sarcandrae 30 parts of Herba plumbaginis indicaes 29 parts of Herba Lycopi 26 parts of Placenta Hominiss 24 parts
Charybdis japonica 22 parts of Concretio silicea Bambusae seu schizostachyis 19 parts of Herba leonuri pseudoma cranthi 17 parts of Herba lagopsis supinaes 14 parts.
5. as described in any one of Claims 1 to 4, treat a preparation method for the medicine of nonspecific vaginitis, it is characterized in that: comprise following processing step:
(1) Pheropsophus jessoensis Mor., Placenta Hominis, Charybdis japonica and Herba leonuri pseudoma cranthi are put into container, carry out pulverization process, grind into powder, cross 180 orders, obtain fine powder, for subsequent use;
(2) by Radix Cucubali, Herba Cynanchi Thesioidis, hang rock wind, Herba plumbaginis indicae, Herba Lycopi, Concretio silicea Bambusae seu schizostachyi and Herba lagopsis supinae and clean, put into container, add the distilled water of 8 ~ 10 times amount, soak after 5 ~ 6 hours, boil 3 ~ 4 hours, extract; Again add 6 ~ 8 times amount distilled water, boil 2 ~ 3 hours, extract; Finally, add 4 ~ 6 times amount distilled water, heated and boiled 1 ~ 2 hour, extract; Merge three extracting solution, filter, obtain filtrate, being condensed into relative density at 60 DEG C is the thick paste of 1.10 ~ 1.13, for subsequent use;
(3) by Radix Bupleuri decontamination, clean, section, dries, is placed in container, mixes thoroughly with vinegar, puts in pot to fry with slow fire to exhaust and micro-dry to vinegar, takes out, dries, be placed in mortar, grind into powder, cross 200 orders, fine powder is for subsequent use;
(4) Herba artemisiae lactiflorae and Herba stellariae mediae are cleaned, chopping, puts into container, strand juice, and filter impurity, stays juice for subsequent use;
(5) Caulis Seu Folium Euonymi Fortunei and Herba Sarcandrae are cleaned, immerse the alcohol solution dipping 1 ~ 2 hour of 60% of 3 times amount, heating extraction 3 hours, reclaim ethanol, filter, obtain filtrate, at simmer down to 65 DEG C, relative density is the thick paste of 1.12 ~ 1.16, for subsequent use;
(6) by fine powder, thick paste and the juice mixing obtained by above-mentioned steps (1) ~ (5), make tablet, obtain the medicine of described treatment nonspecific vaginitis.
CN201410654865.XA 2014-11-17 2014-11-17 Medicine for treating nonspecific vaginitis and preparation method Pending CN104352667A (en)

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CN107596350A (en) * 2017-11-01 2018-01-19 哈尔滨欧替药业有限公司 A kind of recombinant human interferon alpha 2 ε vaginal expansion plugs and preparation method thereof

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107583036A (en) * 2017-11-01 2018-01-16 哈尔滨欧替药业有限公司 A kind of recombinant human interferon alpha 1 b vaginal expansion plug and preparation method thereof
CN107596350A (en) * 2017-11-01 2018-01-19 哈尔滨欧替药业有限公司 A kind of recombinant human interferon alpha 2 ε vaginal expansion plugs and preparation method thereof
CN107583036B (en) * 2017-11-01 2020-04-24 哈尔滨欧替药业有限公司 Recombinant human interferon α 1b vaginal expansion suppository and preparation method thereof
CN107596350B (en) * 2017-11-01 2020-07-14 哈尔滨欧替药业有限公司 Recombinant human interferon expandable vaginal suppository and preparation method thereof

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