CN103611005A - Medicine for treating chronic pharyngitis and preparation method thereof - Google Patents

Abstract

The invention discloses a medicine for treating chronic pharyngitis and a preparation method thereof. The medicine is mainly prepared from the following medicinal materials in a certain weight ratio: astragalus, bighead atractylodes rhizome, Chinese parsnip root, cocklebur fruit, silkworm larva, radix angelicae, fructus forsythiae, liquorice and platycodon grandiflorum. The medicine has the effects of clearing away heat and toxic materials, reducing phlegm and resolving masses and dispelling the wind and relieving pain, is fast in effectiveness in treatment of chronic pharyngitis and has a good curative effect, and the chronic pharyngitis does not reoccur.

Description

A kind of medicine for treating chronic pharyngitis and preparation method thereof

technical field

The invention relates to a medicine for treating chronic pharyngitis and a preparation method thereof, belonging to the field of traditional Chinese medicines.

technical background

Chronic pharyngitis is a diffuse inflammation of the pharyngeal mucosa, submucosal and lymphoid tissues. It is mainly due to incomplete treatment of acute pharyngitis and recurrent episodes, which become chronic, or due to various nasal diseases, nasal orifice blockage, long-term mouth breathing, and physical and chemical factors, neck radiation therapy, etc. often stimulate the pharynx. Sincerely. Various chronic diseases of the whole body, such as anemia, constipation, chronic inflammation of the lower respiratory tract, cardiovascular disease, etc., can also be secondary to this disease. Because western medicine can't effectively treat chronic pharyngitis, and taking western medicine has more side effects, and expense is high, therefore people have great demand to the Chinese medicine medicine of quick and effective treatment chronic pharyngitis, so far, also do not find relevant report about the present invention.

Contents of the invention

The present inventor has finally found a medicine for effectively treating chronic pharyngitis based on the research of the theory of traditional Chinese medicine and the repeated verification of clinical trials, thereby completing the present invention.

The purpose of the present invention is to provide a more effective traditional Chinese medicine combination medicine for treating chronic pharyngitis.

Another object of the present invention is to provide a preparation method of the traditional Chinese medicine combination medicine.

The medicine of the present invention is selected astragalus, Atractylodes macrocephala, Fangfeng, cocklebur, white silkworm, angelica, forsythia, licorice, platycodon, scrophulariaceae, mountain bean root, achyranthes bidentata, hanging golden lamp, coix seed, tangerine peel, wood butterfly, The yam medicine is prepared in combination, and the combination of these medicines makes the efficacy of each medicine produce a synergistic effect, so that chronic pharyngitis can be effectively treated. Select Radix Astragali to be because its nature and flavor are sweet, lukewarm, enter lung, spleen meridian, raw use is beneficial to defend and solidify exterior, diuresis detumescence, detoxification, the function of muscle regeneration, controls spontaneous perspiration, night sweat, arthralgia due to blood, edema, carbuncle ulcer does not ulcerate Or collapse for a long time; Sunburn has the function of nourishing the middle and benefiting, treating internal injury and fatigue, spleen deficiency and diarrhea, prolapse of the anus, qi deficiency and blood loss, collapse and all symptoms of qi deficiency and blood deficiency. Atractylodes macrocephala is selected because its nature and flavor are bitter and sweet, warm, enters the spleen and stomach meridians, has the functions of invigorating the spleen, benefiting the stomach, drying dampness, neutralizing the middle, and controls spleen and stomach qi weakness, lack of appetite, fatigue and lack of qi, bloating, and diarrhea. Diarrhea, phlegm retention, edema, jaundice, arthralgia from dampness, dysuria, dizziness, spontaneous perspiration, restless fetal gas. Select Fangfeng to be because its nature and flavor are pungent and sweet, warm, enter bladder, lung, spleen meridian, have release, expelling wind, eliminating dampness, the function of relieving pain, controls exogenous wind-cold, headache, dizziness, stiff neck, anemofrigid-damp arthralgia, joint pain , limb spasm acute, tetanus. Select Fructus Xanthii to be because its nature and flavor are sweet, warm, poisonous, enter lung, Liver Channel, have dispelling wind, pain relieving, dispelling damp, the function of killing parasites, controls anemofrigid headache, nasal sinusitis, toothache, anemofrigid-damp arthralgia, four parasites. Foot cramps, scabies, itching. Select the white silkworm because its nature and flavor are pungent and salty, flat, enter the liver, lung, and stomach meridian, have the functions of dispelling wind, relieving spasm, resolving phlegm and resolving stagnation, and can treat apoplexy, convulsions, wind in the head, wind in the throat, and sore throat , Scrofula tuberculosis, rheumatoid rash, erysipelas, mastitis. Select Angelica dahurica to be because its nature and flavor are pungent, warm, enter lung, spleen, stomach meridian, have expelling wind, dampness, detumescence, pain relieving function, control headache, brow bone pain, toothache, nasal sinusitis, cold-damp abdominal pain , Intestinal wind and hemorrhoids, red and white vaginal discharge, carbuncle sores, dry itchy skin, scabies. Select forsythia to be because its nature and flavor are bitter, cool, enter the heart, liver, gallbladder meridian, have heat-clearing, detoxification, dissipating stagnation, the function of detumescence, controls warm-heat, erysipelas, macule, carbuncle swollen poison, scrofula, Piss off. Licorice root is selected because its nature and taste are sweet and flat, and it enters the spleen, stomach, and lung meridians, and has the functions of harmonizing urgency, nourishing the lungs, detoxifying, and harmonizing various medicines. Lung impotence, cough, palpitation, carbuncle, used raw to treat sore throat, peptic ulcer, carbuncle sore, antidote poison and food poisoning. Platycodon grandiflorum is selected because its nature and flavor are bitter and pungent, flat, enters the lung and stomach meridians, has the functions of opening lung qi, dispelling phlegm and discharging pus, and can treat cough caused by exogenous pathogenesis, sore throat, lung abscess and vomiting pus, chest fullness and hypochondriac pain, dysentery stomach ache. Scrophulariaceae is selected because of its bitter and salty nature and cool taste, enters the lung and kidney meridian, has the functions of nourishing yin, reducing fire, eliminating annoyance, and detoxifying. Ning, spontaneous sweating, constipation due to Tianjin injury, vomiting blood and epistaxis, sore throat, carbuncle, scrofula. Select Radix Sinensis to be because its nature and flavor are bitter, cold, enter heart, lung, large intestine three warps, have heat-clearing, detoxicating, detumescence, the function of pain relieving, control sore throat, wind in the throat, sore throat, gingival swelling and pain, asthma. Cough with fever, jaundice, diarrhea, hemorrhoids, heat swelling, bald sores, scabies, snake, insect, dog bites. Select Radix Achyranthes Radix to be because its nature and flavor slightly bitter, cool, return liver, kidney channel, have heat-clearing, detoxification, the function of diuresis, control cold and fever, sore throat, urinary calculus, nephritis edema. Selected to be because its nature and flavor are sour, cold, enter liver, spleen two meridians, have heat-clearing, detoxification, diuretic effect, cure bone steaming and fatigue-heat, cough, sore throat, jaundice, edema, eczema of the petechiae. Coix seed is selected because its nature and flavor are sweet and light, cool, enter the spleen, lung, and kidney meridians, and have the functions of invigorating the spleen, nourishing the lungs, clearing away heat, and promoting dampness. , beriberi, lung impotence, lung abscess, intestinal abscess, stranguria, leucorrhea. Select tangerine peel to be because its nature and flavor bitter, pungent, temperature, return lung, spleen meridian, have regulating the flow of vital energy and invigorating the spleen, the function of drying dampness and resolving phlegm, controls chest cavity fullness, indigestion vomiting and diarrhea, cough with abundant phlegm. Wood Butterfly is selected because its nature and flavor are bitter, cold, enters the lung and liver meridian, has the functions of moistening the lung, soothing the liver, harmonizing the stomach, and promoting granulation, and can cure cough, sore throat, hoarseness, liver and stomach pain, and sore . Chinese yam is selected because its nature and flavor are sweet, flat, and enter the lung, spleen, and kidney meridian. It has the functions of strengthening the spleen, nourishing the lung, strengthening the kidney, and benefiting the essence. , Leukorrhagia, frequent urination.

Detailed ways

The dosage of the components of the present invention is also concluded by the inventor after a lot of exploration, and the dosage of each component has a good curative effect within the following weight range

Astragalus 10-20 grams Atractylodes macrocephala 8-18 grams Fangfeng 10-18 grams

Xanthium 8-15 grams White Bombyx mori 8-15 grams Angelica dahurica 10-20 grams

Forsythia 10-22g Licorice 5-15g Bellflower 5-12g

Scrophulariaceae 10-20 grams Shandou root 10-20 grams Achyranthes bidentata 10-20 grams

Hanging Golden Lantern 5-15g Coix Seed 12-25g Chen Peel 8-16g

Wood Butterfly 5-12 grams Yam 10-20 grams

preferably

Astragalus 15 grams Atractylodes macrocephala 12 grams Anti-wind 10 grams

Xanthium 12 grams White Bombyx mori 10 grams Angelica dahurica 10 grams

Forsythia 12 grams Licorice 6 grams Platycodon grandiflorum 6 grams

Scrophulariaceae 12g

Hanging Golden Lantern 6 grams Coix Seed 15 grams Chen Peel 10 grams

Wood butterfly 6 grams yam 12 grams

The preparation method of medicine of the present invention is as follows

1. Preparation

1. Astragalus: remove impurities, remove residual roots and larger hollow roots, soak in water, remove, slice in time after moistening, and dry in the sun;

2. Stir-fried Atractylodes macrocephala: First sprinkle the bran in the hot pot, when the smoke comes out, pour the Atractylodes macrocephala slices into light yellow and stir-fry until light yellow, take it out, sieve off the bran and let it cool. 10 catties of leather;

3. Windproof: Remove the residual stems, soak them in water, remove them, moisten them into slices, and dry them in the sun;

4. Xanthium: pick out impurities, remove thorns, sieve to remove dust, stir-fry until yellow, take out and let cool;

5. Fried silkworm: Sprinkle bran in a hot pan, wait for the smoke to rise, pour in silkworm, fry until yellow, take out, sieve off bran, let cool, use 10 catties of bran for every 100 catties of silkworm;

6. Angelica dahurica: remove impurities, wash with water, soak, remove and moisten thoroughly, and dry until the outer skin has no greasy feeling, then dry the slices after moistening;

7. Forsythia: pick out the impurities, rub it open, and remove the branches;

8. Licorice: remove impurities, wash, soak in water until 80% transparent, remove, moisten and slice, and dry in the sun;

9. Platycodon grandiflorum: pick out the impurities, remove the reed head, wash and remove, slice and dry after moistening;

10. Scrophulariaceae: pick out impurities, wash and moisten thoroughly, slice and dry;

11. Shandou root: pick out impurities, subdivide in thickness, soak in water, remove, slice into slices after moistening, and dry in the sun;

12. Achyranthes bidentata: remove impurities, wash, moisten thoroughly, remove reeds, cut into sections, dry, and sieve to remove debris;

13. Hanging golden lamp: in autumn when the fruit is ripe and the persistent calyx is red or red-yellow, pick it off, remove the fruit or dry it together with the fruit;

14. Stir-fried Coix Seed: Take the cleaned Coix Seed and fry it in a pot with a slow fire until it is slightly yellow, take it out, let it cool, or fry it with bran, 100 catties of Coix Seed, 10 catties of Bran;

15. Tangerine peel: Take the original medicinal materials, remove impurities and blackened peel, wash with water, soften, shred, dry in the sun or at low temperature, and sieve to remove dust;

16. Wood Butterfly: Pick mature fruits from October to December, take out the seeds, and dry or dry them;

17. Stir-fried yam: first spread the bran evenly in the hot pot, wait for the smoke to rise, add yam slices and stir-fry until light yellow, take it out, sieve off the bran, let cool, use 100 pieces of yam slices, use 10 catties of bran .

2. Preparation

1. Put astragalus, Atractylodes macrocephala, Fangfeng, cocklebur, white silkworm, angelica, forsythia, licorice, platycodon, scrophulariaceae, mountain bean root, achyranthes bidentata, hanging golden lamp, coix seed, tangerine peel, wood Add water to decoct the butterflies and yam twice, add 6 times the amount of water for the first time, decoct with strong fire for 10 minutes, then decoct with slow fire for 25 minutes, and filter to obtain the first decoction.

2. Add 4 times the amount of water to the dregs filtered for the first time, decoct with strong fire to boil, then decoct with slow fire for 20 minutes, and filter to obtain the second decoction liquid.

3. Combine the two decoction liquids, boil with high heat, then decoct with slow fire for 10 minutes, divide into 2 doses and take.

The medicine of the invention has the functions of clearing heat and detoxifying, resolving phlegm and dispelling stagnation, expelling wind and relieving pain, and is used for treating chronic pharyngitis with quick effect, good curative effect and no recurrence. The beneficial effects of the medicament of the present invention are further described below through test examples, and these tests include animal toxicity tests and clinical curative effect observation tests of the medicament of the present invention.

[Test example 1] animal toxicity test of medicine of the present invention

Take 30 West German rabbits, both male and female, weighing 2.0-2.5kg, and divide them into two groups, 15 rabbits in each group, one of which is the overdose test group, and the other is the normal dose test group. The overdose test group was 25ml/kg, and the normal amount was 10ml/kg. The administration method was administered by intragastric administration, twice a day, and served for 7 days. The administration reaction was observed every day. Normal, the drug has no adverse side effects. the

[Test example 2] clinical curative effect observation of medicine of the present invention

1. General information

A total of 100 outpatients were admitted, including 36 cases under the age of 30, 41 cases between the age of 31 and 50, and 23 cases over the age of 51.

2. Diagnostic criteria

Chronic pharyngitis is more common in adult, and children also can occur. Systemic symptoms are not obvious, mainly local symptoms. Such as pharyngeal discomfort, foreign body sensation, difficulty coughing up pharyngeal secretions, pharyngeal itching, burning, dryness or irritation, and slight pain. Because the back wall of the pharynx usually has sticky secretions caused by chronic inflammation of the pharynx, and mouth breathing at night due to lesions in the nose, sinuses, and nasopharynx, irritating cough and nausea often occur in the morning. Due to the foreign body sensation in the pharynx, it can be manifested as frequent swallowing. Those who have less pharyngeal secretions and are not easy to cough up often show habitual dry cough and throat clearing actions. If they cough hard or clear their throats, they may cause bleeding of the pharyngeal mucosa, resulting in blood in the secretions.

3. Treatment method

Select the above-mentioned medicament for use, and give it to the patient, 2 times a day, 1 dose each time, and take it warmly twice, 15 days as a course of treatment, and take two courses of treatment continuously.

4. Evaluating Criteria for Efficacy

Significantly effective: the symptoms of chronic pharyngitis are cured and returned to normal;

Improvement: the symptoms of chronic pharyngitis are alleviated, and the condition gradually improves;

Invalid: Those who fail to meet the improvement standard.

5. Treatment results (see the table below):

In above-mentioned treatment, treat chronic pharyngitis patient 100 examples with medicine of the present invention, result is markedly effective 92 examples, and marked rate is 92%, takes a turn for the better 3 examples, and improvement rate is 3%, invalid 5 examples, total effective rate is 95%.

Claims (3)

1. a medicine for the treatment of chronic pharyngitis is characterized in that: it is made from the bulk drug in the following weight ranges: Astragalus 10-20 grams, Atractylodes macrocephala 8-18 grams, Fangfeng 10-18 grams Xanthium 8-15 grams, white silkworm 8-15 grams, Angelica dahurica 10-20 grams Forsythia 10-22 grams Licorice 5-15 grams Bellflower 5-12 grams Scrophulariaceae 10-20 grams, Shandou root 10-20 grams, Achyranthes bidentata 10-20 grams Hanging Golden Lantern 5-15g Coix Seed 12-25g Chen Peel 8-16g Wood butterfly 5-12 grams, yam 10-20 grams. 2. medicine according to claim 1, wherein the consumption of each crude drug is: Astragalus 15 grams, Atractylodes macrocephala 12 grams, Fangfeng 10 grams Xanthium 12 grams, white silkworm 10 grams, Angelica dahurica 10 grams Forsythia 12g Licorice 6g Bellflower 6g Scrophulariaceae 12 grams, Shandou root 12 grams, Achyranthes bidentata 12 grams Hanging Golden Lantern 6 grams Coix Seed 15 grams Chen Peel 10 grams Wood butterfly 6 grams, yam 12 grams. 3. according to the preparation method of described medicine of claim 1 or 2, it is characterized in that: it comprises the following steps: (1) Material preparation (1) Radix Astragali: Clean out impurities, remove residual root heads and larger hollow roots, soak in water, remove, slice in time after moistening, and dry in the sun; (2) Stir-fried Atractylodes macrocephala: first sprinkle the bran in the hot pot, when the smoke comes out, pour the Atractylodes macrocephala slices into light yellow and stir-fry until light yellow, take it out, sieve off the bran and let it cool, 100 catties of Atractylodes macrocephala, use 10 catties bran; (3) Windproof: Remove the residual stems, soak them in water, remove them, moisten them into slices, and dry them in the sun; (4) Xanthium: pick out impurities, remove thorns, sieve to remove dust, slightly fry until yellow, take out and let cool; (5) Fried silkworm: Sprinkle bran in a hot pan, wait for the smoke to rise, pour in silkworm, fry until yellow, take out and sieve off bran, let cool, for every 100 catties of silkworm, use 10 catties of bran ; (6) Angelica dahurica: pick out impurities, wash with water, soak, remove and moisten thoroughly, and dry until the outer skin is not greasy, then dry the slices after moistening; (7) Forsythia: pick out the impurities, rub it open, and remove the branches; (8) Licorice: remove impurities, wash, soak in water until 80% transparent, remove, moisten and slice, and dry in the sun; (9) Platycodon grandiflorum: pick out the impurities, remove the reed head, wash and remove, slice and dry after moistening; (10) Scrophulariaceae: remove impurities, wash and moisten thoroughly, slice and dry; (11) Shandou root: pick out impurities, finely subdivide, soak in water, remove, moisten, slice, and dry; (12) Achyranthes bidentata: remove impurities, wash, moisten thoroughly, remove reeds, cut into sections, dry, and sieve to remove debris; (13) Hanging Golden Lantern: When the fruit is ripe in autumn and the persistent calyx is red or red-yellow, pick it off, remove the fruit or dry it together with the fruit; (14) Stir-fried coix seed: take the cleaned coix seed, put it in a pot, fry it with a slow fire until it is slightly yellow, take it out, let it cool, or fry it with bran, 100 catties of coix seed, 10 catties of bran; (15) Tangerine peel: Take the original medicinal materials, remove impurities and blackened peel, wash with water, soften, shred, dry in the sun or at low temperature, and sieve to remove dust; (16) Wood Butterfly: Pick mature fruits from October to December, take out the seeds, and dry or dry them; (17) Stir-fried yam: First spread the bran evenly in the hot pot, wait for the smoke to rise, add yam slices and stir-fry until light yellow, take it out, sieve off the bran, let cool, 100 pieces of yam slices, use 10 pieces of bran catty; (2) Preparation (1) Astragalus, Atractylodes macrocephala, Fangfeng, Xanthium, white silkworm, angelica, forsythia, licorice, platycodon, scrophulariaceae, mountain bean root, soil achyranthes, hanging golden lamp, coix seed, tangerine peel, Boil the wood butterfly and yam twice with water, add 6 times the amount of water for the first time, boil for 10 minutes with strong fire, then boil for 25 minutes with slow fire, and filter to get the first decoction; (2) Add 4 times the amount of water to the dregs filtered for the first time, decoct with strong fire to boil, then decoct with slow fire for 20 minutes, and filter to obtain the second decoction; (3) Combine the two decoction liquids, boil with high fire, then decoct with slow fire for 10 minutes, divide into 2 doses and take.