CN104524341A - Qingyan granule and preparation method thereof - Google Patents
Qingyan granule and preparation method thereof Download PDFInfo
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- CN104524341A CN104524341A CN201510015399.5A CN201510015399A CN104524341A CN 104524341 A CN104524341 A CN 104524341A CN 201510015399 A CN201510015399 A CN 201510015399A CN 104524341 A CN104524341 A CN 104524341A
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- 239000008187 granular material Substances 0.000 title claims abstract description 70
- 238000002360 preparation method Methods 0.000 title claims description 27
- UAJTZZNRJCKXJN-UHFFFAOYSA-M sodium;2-dodecoxy-2-oxoethanesulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)CS([O-])(=O)=O UAJTZZNRJCKXJN-UHFFFAOYSA-M 0.000 claims abstract description 34
- 210000000582 semen Anatomy 0.000 claims abstract description 27
- 239000002994 raw material Substances 0.000 claims abstract description 19
- 239000000341 volatile oil Substances 0.000 claims description 26
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 12
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- 238000010992 reflux Methods 0.000 claims description 8
- 239000000706 filtrate Substances 0.000 claims description 6
- 239000007779 soft material Substances 0.000 claims description 6
- 239000000080 wetting agent Substances 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 5
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- 244000303040 Glycyrrhiza glabra Species 0.000 abstract 1
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- 206010065334 Mucosal hyperaemia Diseases 0.000 abstract 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 abstract 1
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- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 description 1
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- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/346—Platycodon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/78—Saururaceae (Lizard's-tail family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8994—Coix (Job's tears)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
The invention relates to a qingyan granule. The qingyan granule is composed of extractives of the following raw materials and a sweetening agent. The raw materials comprise, by weight, 20-30 parts of radix platycodonis, 15-25 parts of radix ophiopogonis, 18-26 parts of radix glehniae, 10-20 parts of liquorice, 5-15 parts of corn mint, 5-15 parts of semen coicis and 10-20 parts of herba houttuyniae. The weight part of the sweetening agent is 0-0.3. The qingyan granule is reasonable in formula and rich in bioactive substances such as saponin and polysaccharide, the animal experimental result shows that rat voix pedis swelling can be obviously lightened, and the human experimental result shows that pharyngeal mucosal hyperemia and mucosa edema can be obviously lightened. The qingyan granule has the advantages that the health care effect of clearing heat from the throat is achieved, the function is lasting, the source of the raw materials is wide, the quality is reliable and the qingyan granule is affordable.
Description
Technical field
The present invention relates to a kind of Qingyan Granules and preparation method thereof, belong to field of health care food.
Background technology
In recent years due to air quality decline, the stimulation of pungent diet and tobacco and wine, laryngopharyngeal diseases sickness rate is obviously increased, becomes the large factor be detrimental to health.Especially for the workman of operation under high-temperature dust of being everlasting, too much harmful gas environment with the more teacher of throat, shop-assistant, performer and malnutrition, suffer from the people that body illness causes Abwehrkraft des Koepers to decline, often there is throat problem.Not only affect people and carry out Verbal interaction and sleep during laryngopharyngeal diseases morbidity, especially on to be engaged in teaching and Energy of Vocal Music person directly affects carrying out of work.And the pathological change that the active chronic inflammation of pharynx causes, not only causes the malfunction of pharynx local, also can involve contiguous organ-tissue, bring out other diseases.
Because the harm of laryngopharyngeal diseases is very large, throat expert advice, preventing and controlling laryngopharyngeal diseases, will be placed on emphasis, importantly enhancing body defence capability anti-.Moistening and cleaning throat health food had both had the nutrition general character of normal food, had again the special roles such as antiinflammatory is antibacterial, the cough-relieving that wets one's whistle, elimination is swollen and ache, heat-clearing and toxic substances removing, recovery vocal cords are tired, can be used for throat health care, prevention laryngopharyngeal diseases.
Moistening and cleaning throat health food is mainly refined by the herbal raw material with effects of clearing and nourishing throat.Research shows that the Chinese herbal medicine with effects of clearing and nourishing throat has: green tea, Semen Sterculiae Lychnophorae, Flos Lonicerae, Herba Menthae, Fructus Momordicae, Flos Chrysanthemi, Fructus Canarii, Herba Houttuyniae, Herba Pileae Scriptae, watermelon crystal, Rabdosia rubescens, Radix Glycyrrhizae, Exocarpium Citri Rubrum, Fructus Gardeniae, Radix Platycodonis etc.But the effect that these above-mentioned materials are single is all undesirable.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of Qingyan Granules, overcomes the single limited efficiency of medicinal herbs in cleaning throat and moistening larynx of the prior art, can not give full play to the defect of effect of each material.
The technical scheme that the present invention solves the problems of the technologies described above is as follows: a kind of Qingyan Granules, be made up of the extract of following raw material and sweeting agent, described raw material is: Radix Platycodonis 20 ~ 30 weight portion, Radix Ophiopogonis 15 ~ 25 weight portion, Radix Glehniae 18 ~ 26 weight portion, Radix Glycyrrhizae 10 ~ 20 weight portion, Herba Menthae 5 ~ 15 weight portion, Semen Coicis 5 ~ 15 weight portion and Herba Houttuyniae 10 ~ 20 weight portion; Described sweeting agent is 0 ~ 0.3 weight portion.
On the basis of technique scheme, the present invention can also do following improvement.
The present invention's a kind of Qingyan Granules described above, further, described raw material is: Radix Platycodonis 25 weight portion, Radix Ophiopogonis 20 weight portion, Radix Glehniae 22 weight portion, Radix Glycyrrhizae 15 weight portion, Herba Menthae 10 weight portion, Semen Coicis 10 weight portion and Herba Houttuyniae 15 weight portion.
The present invention's a kind of Qingyan Granules described above, further, described raw material is: Radix Platycodonis 24 weight portion, Radix Ophiopogonis 18 weight portion, Radix Glehniae 20 weight portion, Radix Glycyrrhizae 16 weight portion, Herba Menthae 11 weight portion, Semen Coicis 11 weight portion and Herba Houttuyniae 16 weight portion.
The present invention's a kind of Qingyan Granules described above, further, described sweeting agent is mogroside.
The present invention also provides a kind of preparation method of Qingyan Granules, comprises the following steps:
Step (1), Herba Menthae and Herba Houttuyniae extract volatile oil preparation: the Herba Houttuyniae taking the Herba Menthae of 5 ~ 15 weight portions and 10 ~ 20 weight portions respectively or mixing be placed in extraction pot and add water, heating and refluxing extraction, collect volatile oil for subsequent use;
Step (2), the preparation of Radix Platycodonis, Radix Ophiopogonis, Radix Glehniae, Radix Glycyrrhizae and Semen Coicis extract powder: take the Radix Platycodonis of 20 ~ 30 weight portions, Radix Ophiopogonis of 15 ~ 25 weight portions, the Radix Glehniae of 18 ~ 26 weight portions, the Radix Glycyrrhizae of 10 ~ 20 weight portions and 5 ~ 15 weight portions Semen Coicis respectively or mixing be placed in extraction pot and add flooding, concentrated and dry;
Step (3), mixing preparation: the sweeting agent of Radix Platycodonis step (2) prepared, Radix Ophiopogonis, Radix Glehniae, Radix Glycyrrhizae and Semen Coicis extract powder and 0 ~ 0.3 weight portion is in high speed wet granulator, add ethanol and do wetting agent soft material, cross the wet granular of 12 ~ 20 mesh sieves, by wet grain drying to moisture≤3%, obtain dry granule; Mixing preparation operates in 300,000 grades of dust proof workshops;
The Herba Menthae that step (1) obtains by step (4) and Herba Houttuyniae extract volatile oil and spray into obtained Qingyan Granules in the dry granule that step (4) obtains.
The preparation method of the present invention's a kind of Qingyan Granules described above, further, the Herba Houttuyniae that step (1) takes the Herba Menthae of 5 ~ 15 weight portions and 10 ~ 20 weight portions respectively or mixing be placed in the water that extraction pot adds 10 times amount, heating and refluxing extraction 2h, collects volatile oil for subsequent use.
The preparation method of the present invention's a kind of Qingyan Granules described above, further, step (2) adds flooding twice, first time adds the water extraction 2 hours of 10 times amount, and 100 orders filter, and second time adds 8 times of water gagings, extract 1.5h, 100 orders filter, and merge twice filtrate.
The preparation method of the present invention's a kind of Qingyan Granules described above, further, step (2) is concentrated is be-0.06--0.08MPa at pressure, and temperature 70-80 DEG C is evaporated to relative density is 1.06-1.1.
The preparation method of the present invention's a kind of Qingyan Granules described above, further, step (2) drying is spraying dry, and obtain dried powder, dried powder pulverized 80 mesh sieves.
The preparation method of the present invention's a kind of Qingyan Granules described above, further, Herba Menthae step (1) obtained in step (4) and Herba Houttuyniae extract volatile oil and spray into airtight 24h in the dry granule that step (4) obtains.
The invention has the beneficial effects as follows: Radix Platycodonis of the present invention, Radix Ophiopogonis, Radix Glehniae, Radix Glycyrrhizae, Herba Menthae, Semen Coicis, Herba Houttuyniae are primary raw material and by the synergism between these materials, be aided with mogroside, relieving sore-throat by clearing away heat, YIN nourishing and the production of body fluid promoting, dispersing lung-QI and dissipating phlegm can be played, reach the health-care effect of moistening and cleaning throat and persistent, raw material sources are extensive, the material benefit of reliable in quality, price.
This formula for a product is reasonable, is rich in saponin, the bioactive substances such as polysaccharide.Show through results of animal: obviously can alleviate rat paw edema; Human test results shows: obviously can alleviate pharyngeal mucosa congested, mucosa edema.Illustrate that this product has the effect of moistening and cleaning throat.
This product technique is easy to operation, and without special installation and chemical reagent, production safety, process conditions are basicly stable, process problem, be suitable for industrialized great production without " three wastes ".
Detailed description of the invention
Be described principle of the present invention and feature with the following Examples, example, only for explaining the present invention, is not intended to limit scope of the present invention.
Embodiment 1
A kind of Qingyan Granules of the present invention, is made up of following raw material: Radix Platycodonis 20kg, Radix Ophiopogonis 18kg, Radix Glehniae 20kg, Radix Glycyrrhizae 15kg, Herba Menthae 6.7kg, Semen Coicis 10kg, Herba Houttuyniae 10kg, mogroside 0.3kg.
Prepare Qingyan Granules as above to comprise the steps:
(1) preparation of Herba Menthae, Herba Houttuyniae extraction volatile oil
Take Herba Menthae 6.7kg, Herba Houttuyniae 10kg is placed in the water that extraction pot adds 10 times amount, heating and refluxing extraction 4h, collect volatile oil for subsequent use.
(2) preparation of Radix Platycodonis, Radix Ophiopogonis, Radix Glehniae, Radix Glycyrrhizae, Semen Coicis extract xeraphium
Take Radix Platycodonis 20kg, Radix Ophiopogonis 18kg, Radix Glehniae 20kg, Radix Glycyrrhizae 15kg, Semen Coicis 10kg adopt water extraction twice, first time adds the water extraction 2 hours of 10 times amount, 100 orders filter, second time adds 8 times of water gagings, extract 1.5h, 100 orders filter, and merge twice filtrate, be-0.08MPa at pressure, it is 1.1 that temperature 80 DEG C is evaporated to relative density.Spray-driedly obtain dried powder, dried powder pulverized 80 mesh sieves, made dry powder for subsequent use;
(3) mixing granulation is allocated
At the dried powder that step (2) is prepared by 300,000 grades of dust proof workshops, mix homogeneously with the mogroside of 80 mesh sieves, in high speed wet granulator, add 80% ethanol and do wetting agent soft material, cross 18 mesh sieves and granulate.Under state wet granular being placed in 60 DEG C, be dried to moisture≤3%, obtain dry granule, by for subsequent use for dry granule granulate.
(4) Herba Menthae, Herba Houttuyniae extract volatile oil
The volatile oil that step (1) obtains is sprayed in the dry granule that step (3) obtains, airtight 24h.
(5) subpackage
By the granule subpackage be on request up to the standards, outsourcing.
(6) product inspection, warehouse-in
As requested every detection is carried out to finished product, the warehouse-in conformed with the regulations.
Embodiment 2
A kind of Qingyan Granules of the present invention, is made up of following raw material: Radix Platycodonis 25kg, Radix Ophiopogonis 15kg, Radix Glehniae 18kg, Radix Glycyrrhizae 10kg, Herba Menthae 8kg, Semen Coicis 8.7kg, Herba Houttuyniae 15kg, mogroside 0.3kg.
Prepare Qingyan Granules as above to comprise the steps:
(1) Herba Menthae, Herba Houttuyniae extract volatile oil
Take Herba Menthae 8kg and Herba Houttuyniae 15kg and be placed in the water that extraction pot adds 10 times amount, heating and refluxing extraction 4h, collect volatile oil for subsequent use.
(2) preparation of Radix Platycodonis, Radix Ophiopogonis, Radix Glehniae, Radix Glycyrrhizae, Semen Coicis extract xeraphium
Take Radix Platycodonis 25kg, Radix Ophiopogonis 15kg, Radix Glehniae 18kg, Radix Glycyrrhizae 10kg, Semen Coicis 8.7kg water extraction twice, first time adds the water extraction 2 hours of 10 times amount, and 100 orders filter, and second time adds 8 times of water gagings, extract 1.5h, 100 orders filter, and merging twice filtrate, is-0.06MPa at pressure, it is 1.1 that temperature 80 DEG C is evaporated to relative density, spray-driedly obtain dried powder, dried powder pulverized 80 mesh sieves, made dry powder for subsequent use;
(3) mixing granulation is allocated
At the dried powder that step (2) is prepared by 300,000 grades of dust proof workshops, mix homogeneously with the mogroside of 80 mesh sieves, in high speed wet granulator, add 80% ethanol and do wetting agent soft material, cross 18 mesh sieves and granulate.Under state wet granular being placed in 60 DEG C, be dried to moisture≤3%, obtain dry granule, by for subsequent use for dry granule granulate.
(4) volatile oil is sprayed into
The volatile oil that step (1) obtains is sprayed in the dry granule that step (4) obtains, airtight 24h.
(5) subpackage:
By the granule subpackage be on request up to the standards, outsourcing.
(6) product inspection, warehouse-in
As requested every detection is carried out to finished product, the warehouse-in conformed with the regulations.
Embodiment 3
A kind of Qingyan Granules of the present invention, is made up of following raw material: Radix Platycodonis 30kg, Radix Ophiopogonis 16kg, Radix Glehniae 19kg, Radix Glycyrrhizae 12kg, Herba Menthae 5kg, Semen Coicis 6kg, Herba Houttuyniae 11.7kg, mogroside 0.3kg.
Prepare Qingyan Granules as above to comprise the steps:
(1) Herba Menthae, Herba Houttuyniae extract volatile oil
Take Herba Menthae 5kg and Herba Houttuyniae 11.7kg and be placed in the water that extraction pot adds 10 times amount, heating and refluxing extraction 4h, collect volatile oil for subsequent use.
(2) preparation of Radix Platycodonis, Radix Ophiopogonis, Radix Glehniae, Radix Glycyrrhizae, Semen Coicis extract xeraphium
Take Radix Platycodonis 30kg, Radix Ophiopogonis 16kg, Radix Glehniae 19kg, Radix Glycyrrhizae 12kg, Semen Coicis 6kg water extraction twice, first time adds the water extraction 2 hours of 10 times amount, 100 orders filter, second time adds 8 times of water gagings, extract 1.5h, 100 orders filter, and merge twice filtrate, be-0.08MPa at pressure, it is 1.1 that temperature 80 DEG C is evaporated to relative density.Spray-driedly obtain dried powder, dried powder pulverized 80 mesh sieves, made dry powder for subsequent use;
(3) mixing granulation is allocated
At the dried powder that step (2) is prepared by 300,000 grades of dust proof workshops, mix homogeneously with the mogroside of 80 mesh sieves, in high speed wet granulator, add 80% ethanol and do wetting agent soft material, cross 18 mesh sieves and granulate.Under state wet granular being placed in 60 DEG C, be dried to moisture≤3%, obtain dry granule, by for subsequent use for dry granule granulate.
(4) Herba Menthae, Herba Houttuyniae extract volatile oil
The volatile oil that step (1) obtains is sprayed in the dry granule that step (4) obtains, airtight 24h.
(5) subpackage
By the granule subpackage be on request up to the standards, outsourcing.
(6) product inspection, warehouse-in
As requested every detection is carried out to finished product, the warehouse-in conformed with the regulations.
Embodiment 4
A kind of Qingyan Granules of the present invention, is made up of following raw material: Radix Platycodonis 25kg, Radix Ophiopogonis 20kg, Radix Glehniae 22kg, Radix Glycyrrhizae 15kg, Herba Menthae 10kg, Semen Coicis 10kg, Herba Houttuyniae 15kg, mogroside 0.3kg.
Prepare Qingyan Granules as above to comprise the steps:
(1) Herba Menthae, Herba Houttuyniae extract volatile oil
Take Herba Menthae 10kg and Herba Houttuyniae 15kg and be placed in the water that extraction pot adds 10 times amount, heating and refluxing extraction 4h, collect volatile oil for subsequent use.
(2) preparation of Radix Platycodonis, Radix Ophiopogonis, Radix Glehniae, Radix Glycyrrhizae, Semen Coicis extract xeraphium
Take Radix Platycodonis 25kg, Radix Ophiopogonis 20kg, Radix Glehniae 22kg, Radix Glycyrrhizae 15kg, Semen Coicis 10kg water extraction twice, first time adds the water extraction 2 hours of 10 times amount, 100 orders filter, second time adds 8 times of water gagings, extract 1.5h, 100 orders filter, and merge twice filtrate, be-0.08MPa at pressure, it is 1.1 that temperature 80 DEG C is evaporated to relative density.Spray-driedly obtain dried powder, dried powder pulverized 80 mesh sieves, made dry powder for subsequent use;
(3) mixing granulation is allocated
At the dried powder that step (2) is prepared by 300,000 grades of dust proof workshops, mix homogeneously with the mogroside 0.3kg of 80 mesh sieves, in high speed wet granulator, add 80% ethanol and do wetting agent soft material, cross 18 mesh sieves and granulate.Under state wet granular being placed in 60 DEG C, be dried to moisture≤3%, obtain dry granule, by for subsequent use for dry granule granulate.
(4) Herba Menthae, Herba Houttuyniae extract volatile oil
The volatile oil that step (1) obtains is sprayed in the dry granule that step (4) obtains, airtight 24h.
(5) subpackage
By the granule subpackage be on request up to the standards, outsourcing.
(6) product inspection, warehouse-in
As requested every detection is carried out to finished product, the warehouse-in conformed with the regulations.
Function assessment is tested
Function of moistening and cleaning throat
Laboratory animal: male SD rat, 150-220g.
Experimental technique and step: rat is divided into blank group and 3 given the test agent dosage groups by body weight, blank group is given and solvent.The same day was given a given the test agent in experiment end again, and after 1 hour in the Rat Right metapedes sole of the foot subcutaneous injection 1% carrageenin 0.1ml/ only, respectively at extremely scorching latter 1,3,6 hour, measure each genus sufficient sole of the foot portion thickness, same position measures 3 times, averages.
Result shows, and 4 right back foots of test group of animals are compared with left foot, and what all occur in various degree is red, swollen, and the slight heating of swelling foot, the situations such as irritated, foot of crossing mountains, right back foot dare not land appear in animal.Compare with blank group, middle and high dosage group all obviously can suppress the rat paw edema degree caused by carrageenin, rapid-action, lh can reach obvious inhibition upon administration, duration of efficacy is long, can continue until more than 6h, Qingyan Granules middle and high dosage group prepared by the present embodiment all has significant inhibition (P<0.01) in each period.
Table 1 sample on Carrageenan causes the impact (x scholar s) of rat paw edema
* compares with matched group, P < 0.01.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. a Qingyan Granules, it is characterized in that, be made up of the extract of following raw material and sweeting agent, described raw material is: Radix Platycodonis 20 ~ 30 weight portion, Radix Ophiopogonis 15 ~ 25 weight portion, Radix Glehniae 18 ~ 26 weight portion, Radix Glycyrrhizae 10 ~ 20 weight portion, Herba Menthae 5 ~ 15 weight portion, Semen Coicis 5 ~ 15 weight portion and Herba Houttuyniae 10 ~ 20 weight portion; Described sweeting agent is 0 ~ 0.3 weight portion.
2. a kind of Qingyan Granules according to claim 1, it is characterized in that, described raw material is: Radix Platycodonis 25 weight portion, Radix Ophiopogonis 20 weight portion, Radix Glehniae 22 weight portion, Radix Glycyrrhizae 15 weight portion, Herba Menthae 10 weight portion, Semen Coicis 10 weight portion and Herba Houttuyniae 15 weight portion.
3. a kind of Qingyan Granules according to claim 1, it is characterized in that, described raw material is: Radix Platycodonis 24 weight portion, Radix Ophiopogonis 18 weight portion, Radix Glehniae 20 weight portion, Radix Glycyrrhizae 16 weight portion, Herba Menthae 11 weight portion, Semen Coicis 11 weight portion and Herba Houttuyniae 16 weight portion.
4. a kind of Qingyan Granules according to any one of claims 1 to 3, is characterized in that, described sweeting agent is mogroside.
5. a preparation method for Qingyan Granules, is characterized in that, comprises the following steps:
Step (1), Herba Menthae and Herba Houttuyniae extract volatile oil preparation: according to the weight ratio described in any one of claims 1 to 3 take Herba Menthae and Herba Houttuyniae respectively or mixing be placed in extraction pot and add water, heating and refluxing extraction, collect volatile oil;
Step (2), the preparation of Radix Platycodonis, Radix Ophiopogonis, Radix Glehniae, Radix Glycyrrhizae and Semen Coicis extract powder: according to the weight ratio described in any one of claims 1 to 3 take Radix Platycodonis, Radix Ophiopogonis, Radix Glehniae, Radix Glycyrrhizae, Semen Coicis respectively or mixing be placed in that extraction pot adds flooding, powder is made in concentrated and drying;
Step (3), mixing preparation: Radix Platycodonis step (2) prepared, Radix Ophiopogonis, Radix Glehniae, Radix Glycyrrhizae and Semen Coicis extract powder and sweeting agent are in high speed wet granulator, add ethanol and do wetting agent soft material, cross the wet granular of 12 ~ 20 mesh sieves, by wet grain drying to moisture≤3%, obtain dry granule;
The Herba Menthae that step (1) obtains by step (4) and Herba Houttuyniae extract volatile oil and spray into obtained Qingyan Granules in the dry granule that step (3) obtains.
6. according to the preparation method of claim 5 Qingyan Granules, it is characterized in that, step (1) according to the weight ratio described in any one of claims 1 to 3 take Herba Menthae and Herba Houttuyniae respectively or mixing be placed in the water that extraction pot adds raw material total amount 10 times, heating and refluxing extraction 2h, collects volatile oil for subsequent use.
7. a kind of preparation method of Qingyan Granules according to claim 5 or 6, it is characterized in that, step (2) adds flooding twice, first time adds the water extraction 2 hours of 10 times amount, 100 orders filter, and second time adds raw material total amount 8 times of water, extract 1.5h, 100 orders filter, and merge twice filtrate.
8. a kind of preparation method of Qingyan Granules according to claim 5 or 6, is characterized in that, step (2) is concentrated is be-0.06--0.08MPa at pressure, and temperature 70-80 DEG C is evaporated to relative density is 1.06-1.1.
9. a kind of preparation method of Qingyan Granules according to claim 5 or 6, it is characterized in that, step (2) drying is spraying dry, and obtain dried powder, dried powder pulverized 80 mesh sieves.
10. a kind of preparation method of Qingyan Granules according to claim 5 or 6, it is characterized in that, Herba Menthae step (1) obtained in step (4) and Herba Houttuyniae extract volatile oil and spray into airtight 24h in the dry granule that step (3) obtains.
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| CN106822755A (en) * | 2017-01-12 | 2017-06-13 | 张超英 | One kind is relieved the effect of alcohol guttural tablets and preparation method thereof |
| CN110313597A (en) * | 2018-11-13 | 2019-10-11 | 广东一方制药有限公司 | One kind is instant to be exempted to rush throat soothing particle and preparation method thereof |
| CN110558416A (en) * | 2019-09-24 | 2019-12-13 | 商洛学院 | Throat clearing buccal tablet and preparation method thereof |
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| CN101062270A (en) * | 2007-05-30 | 2007-10-31 | 方阳 | Mint glycyrrhiza decoction |
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| CN103125629A (en) * | 2011-11-23 | 2013-06-05 | 鲜丹科 | Throat nourishing tea |
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| CN106822755A (en) * | 2017-01-12 | 2017-06-13 | 张超英 | One kind is relieved the effect of alcohol guttural tablets and preparation method thereof |
| CN110313597A (en) * | 2018-11-13 | 2019-10-11 | 广东一方制药有限公司 | One kind is instant to be exempted to rush throat soothing particle and preparation method thereof |
| CN110558416A (en) * | 2019-09-24 | 2019-12-13 | 商洛学院 | Throat clearing buccal tablet and preparation method thereof |
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